locus-tag	class	description
HIN88_RS00010	COG0592	DNA-directed DNA polymerase activity
HIN88_RS00020	COG0187	DNA topoisomerase II activity
HIN88_RS00030	COG0586	Pfam SNARE associated Golgi protein
HIN88_RS00035	COG0488	(ABC) transporter
HIN88_RS00060	COG0596	Alpha beta hydrolase
HIN88_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HIN88_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIN88_RS00110	COG0733	neurotransmitter:sodium symporter activity
HIN88_RS00150	COG2233	PERMEase
HIN88_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS00200	COG2814	Major facilitator Superfamily
HIN88_RS00205	COG0656	L-ascorbic acid biosynthetic process
HIN88_RS00210	COG0583	DNA-binding transcription factor activity
HIN88_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_RS00230	COG1064	alcohol dehydrogenase
HIN88_RS00235	COG2818	Glycosylase
HIN88_RS00250	COG1194	a g-specific adenine glycosylase
HIN88_RS00270	COG2983	Belongs to the UPF0260 family
HIN88_RS00275	COG2133	pyrroloquinoline quinone binding
HIN88_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HIN88_RS00285	COG2116	formate transmembrane transporter activity
HIN88_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_RS00310	COG1335	isochorismatase
HIN88_RS00315	COG0385	Bile acid
HIN88_RS00320	COG1683	Conserved Protein
HIN88_RS00340	COG0625	glutathione transferase activity
HIN88_RS00350	COG1113	amino acid transport
HIN88_RS00360	COG0523	cobalamin synthesis protein
HIN88_RS00370	COG2188	Transcriptional regulator
HIN88_RS00400	COG0010	Belongs to the arginase family
HIN88_RS00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN88_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIN88_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HIN88_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIN88_RS00540	COG0534	Mate efflux family protein
HIN88_RS00545	COG0436	Aminotransferase
HIN88_RS00550	COG2733	membrane
HIN88_RS00565	COG2918	glutathione biosynthetic process
HIN88_RS00575	COG3501	Rhs element vgr protein
HIN88_RS00625	COG3150	esterase
HIN88_RS00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HIN88_RS00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_RS00655	COG2233	PERMEase
HIN88_RS00660	COG2351	hydroxyisourate hydrolase activity
HIN88_RS00710	COG1393	Belongs to the ArsC family
HIN88_RS00715	COG0708	Exodeoxyribonuclease III
HIN88_RS00735	COG0189	ligase activity
HIN88_RS00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HIN88_RS00765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIN88_RS00780	COG4942	peptidase
HIN88_RS00790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN88_RS00800	COG2119	membrane
HIN88_RS00805	COG4774	siderophore transport
HIN88_RS00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_RS00810	COG0426	domain, Protein
HIN88_RS00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HIN88_RS00855	COG1902	pentaerythritol trinitrate reductase activity
HIN88_RS00860	COG1519	Transferase
HIN88_RS00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN88_RS00870	COG0668	transmembrane transport
HIN88_RS00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_RS00885	COG1335	isochorismatase
HIN88_RS00890	COG1522	sequence-specific DNA binding
HIN88_RS00915	COG0784	Response regulator, receiver
HIN88_RS00915	COG2205	protein histidine kinase activity
HIN88_RS00915	COG2198	Histidine kinase
HIN88_RS00920	COG3162	membrane
HIN88_RS00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN88_RS00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_RS00945	COG3706	GGDEF domain
HIN88_RS00955	COG1309	transcriptional regulator
HIN88_RS00975	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_RS00975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN88_RS00975	COG0351	phosphomethylpyrimidine kinase
HIN88_RS00985	COG2814	Major facilitator Superfamily
HIN88_RS01000	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN88_RS01010	COG1113	amino acid transport
HIN88_RS01020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN88_RS01025	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS01035	COG1335	isochorismatase
HIN88_RS01105	COG2814	Major facilitator Superfamily
HIN88_RS01130	COG0667	Aldo Keto reductase
HIN88_RS01165	COG1733	regulation of RNA biosynthetic process
HIN88_RS01170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_RS01230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HIN88_RS01275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIN88_RS01305	COG0427	acetyl-CoA hydrolase
HIN88_RS01320	COG0745	RESPONSE REGULATOR receiver
HIN88_RS01330	COG0659	secondary active sulfate transmembrane transporter activity
HIN88_RS01335	COG4221	oxidoreductase activity
HIN88_RS01345	COG0488	(ABC) transporter
HIN88_RS01410	COG0833	amino acid
HIN88_RS01455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIN88_RS01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HIN88_RS01475	COG2226	methyltransferase
HIN88_RS01525	COG0069	glutamate synthase activity
HIN88_RS01525	COG0067	glutamate synthase
HIN88_RS01525	COG0070	glutamate synthase
HIN88_RS01530	COG0493	'glutamate synthase
HIN88_RS01540	COG1704	LemA family
HIN88_RS01545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HIN88_RS01560	COG3307	-O-antigen
HIN88_RS01580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN88_RS01595	COG0194	GDP metabolic process
HIN88_RS01645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIN88_RS01665	COG5380	lipid catabolic process
HIN88_RS01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIN88_RS01695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIN88_RS01700	COG0277	FAD linked oxidase domain protein
HIN88_RS01710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HIN88_RS01715	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_RS01730	COG1289	transmembrane transporter activity
HIN88_RS01740	COG0628	permease
HIN88_RS01745	COG1192	Involved in chromosome partitioning
HIN88_RS01775	COG0833	amino acid
HIN88_RS01780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN88_RS01785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN88_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS01835	COG0583	DNA-binding transcription factor activity
HIN88_RS01880	COG0517	IMP dehydrogenase activity
HIN88_RS01885	COG1983	PspC domain protein
HIN88_RS01895	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS01910	COG0408	coproporphyrinogen oxidase activity
HIN88_RS01930	COG0513	Belongs to the DEAD box helicase family
HIN88_RS01940	COG1127	ABC transporter
HIN88_RS01945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HIN88_RS01955	COG2854	intermembrane phospholipid transfer
HIN88_RS01965	COG0598	Magnesium transport protein CorA
HIN88_RS01975	COG0494	nUDIX hydrolase
HIN88_RS01980	COG1040	competence protein
HIN88_RS01985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIN88_RS02005	COG1946	Acyl-CoA thioesterase
HIN88_RS02010	COG1301	dicarboxylic acid transport
HIN88_RS02025	COG1959	2 iron, 2 sulfur cluster binding
HIN88_RS02030	COG1017	nitric oxide dioxygenase activity
HIN88_RS02030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_RS02040	COG0433	COG0433 Predicted ATPase
HIN88_RS02045	COG0626	cystathionine gamma-synthase activity
HIN88_RS02200	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS02205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HIN88_RS02235	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HIN88_RS02240	COG0339	signal peptide processing
HIN88_RS02245	COG0557	exoribonuclease II activity
HIN88_RS02290	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIN88_RS02295	COG2169	Transcriptional regulator
HIN88_RS02300	COG0697	spore germination
HIN88_RS02305	COG1295	ribonuclease BN
HIN88_RS02340	COG1702	phosphate starvation-inducible protein PhoH
HIN88_RS02350	COG0741	lytic transglycosylase activity
HIN88_RS02350	COG0739	heme binding
HIN88_RS02350	COG1196	nuclear chromosome segregation
HIN88_RS02380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HIN88_RS02385	COG1183	phosphatidylcholine synthase activity
HIN88_RS02430	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS02435	COG1309	transcriptional regulator
HIN88_RS02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN88_RS02455	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS02475	COG2969	positive regulation of protein catabolic process
HIN88_RS02485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HIN88_RS02500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HIN88_RS02505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN88_RS02525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIN88_RS02535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN88_RS02540	COG1408	metallophosphoesterase
HIN88_RS02550	COG2199	diguanylate cyclase activity
HIN88_RS02610	COG1607	acyl-coa hydrolase
HIN88_RS02640	COG2350	Protein conserved in bacteria
HIN88_RS02650	COG0613	PHP domain protein
HIN88_RS02655	COG3781	membrane
HIN88_RS02665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIN88_RS02670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIN88_RS02680	COG1862	Preprotein translocase
HIN88_RS02715	COG2205	protein histidine kinase activity
HIN88_RS02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HIN88_RS02735	COG0726	polysaccharide deacetylase
HIN88_RS02740	COG0438	transferase activity, transferring glycosyl groups
HIN88_RS02750	COG0438	transferase activity, transferring glycosyl groups
HIN88_RS02765	COG1442	glycosyl transferase family 8
HIN88_RS02820	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS02825	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS02835	COG2205	protein histidine kinase activity
HIN88_RS02840	COG0745	RESPONSE REGULATOR receiver
HIN88_RS02845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HIN88_RS02865	COG2096	Adenosyltransferase
HIN88_RS02915	COG0285	dihydrofolate synthase activity
HIN88_RS02935	COG0450	alkyl hydroperoxide reductase
HIN88_RS02950	COG0477	Major facilitator Superfamily
HIN88_RS02955	COG1272	protein, Hemolysin III
HIN88_RS02985	COG0183	Belongs to the thiolase family
HIN88_RS02990	COG2207	Transcriptional regulator
HIN88_RS03010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_RS03030	COG0183	Belongs to the thiolase family
HIN88_RS03040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HIN88_RS03040	COG2885	chlorophyll binding
HIN88_RS03050	COG1690	Belongs to the RtcB family
HIN88_RS03055	COG0833	amino acid
HIN88_RS03065	COG2233	PERMEase
HIN88_RS03095	COG2094	Belongs to the DNA glycosylase MPG family
HIN88_RS03100	COG4772	TonB-dependent receptor
HIN88_RS03105	COG1902	pentaerythritol trinitrate reductase activity
HIN88_RS03120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_RS03125	COG0354	folic acid binding
HIN88_RS03135	COG3189	MarR family transcriptional regulator
HIN88_RS03140	COG2824	Alkylphosphonate utilization operon protein PhnA
HIN88_RS03145	COG3422	double-strand break repair
HIN88_RS03185	COG0840	transmembrane signaling receptor activity
HIN88_RS03200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIN88_RS03215	COG5510	response to toxic substance
HIN88_RS03225	COG2832	Protein of unknown function (DUF454)
HIN88_RS03230	COG1376	ErfK ybiS ycfS ynhG family protein
HIN88_RS03270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HIN88_RS03280	COG1289	transmembrane transporter activity
HIN88_RS03285	COG2814	Major facilitator Superfamily
HIN88_RS03305	COG1115	amino acid carrier protein
HIN88_RS03310	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN88_RS03315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN88_RS03320	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIN88_RS03345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN88_RS03355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN88_RS03360	COG1077	Cell shape determining protein MreB Mrl
HIN88_RS03365	COG1792	Involved in formation and maintenance of cell shape
HIN88_RS03370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HIN88_RS03375	COG0424	maF-like protein
HIN88_RS03380	COG1530	ribonuclease E activity
HIN88_RS03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_RS03400	COG0560	Phosphoserine phosphatase
HIN88_RS03410	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_RS03435	COG2207	Transcriptional regulator
HIN88_RS03455	COG1113	amino acid transport
HIN88_RS03460	COG2828	Protein conserved in bacteria
HIN88_RS03465	COG0142	geranyltranstransferase activity
HIN88_RS03470	COG2315	Protein conserved in bacteria
HIN88_RS03485	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN88_RS03505	COG2194	sulfuric ester hydrolase activity
HIN88_RS03510	COG0745	RESPONSE REGULATOR receiver
HIN88_RS03515	COG0642	Histidine kinase
HIN88_RS03525	COG0004	ammonium transporteR
HIN88_RS03530	COG0583	DNA-binding transcription factor activity
HIN88_RS03550	COG0525	valine-tRNA ligase activity
HIN88_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS03570	COG0393	Putative heavy-metal-binding
HIN88_RS03575	COG0393	Putative heavy-metal-binding
HIN88_RS03580	COG1538	Outer membrane efflux protein
HIN88_RS03590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS03625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HIN88_RS03640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HIN88_RS03640	COG1648	precorrin-2 dehydrogenase activity
HIN88_RS03645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIN88_RS03650	COG1733	regulation of RNA biosynthetic process
HIN88_RS03660	COG0531	amino acid
HIN88_RS03675	COG0321	lipoyl(octanoyl) transferase activity
HIN88_RS03680	COG2921	Belongs to the UPF0250 family
HIN88_RS03715	COG2009	succinate dehydrogenase
HIN88_RS03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HIN88_RS03725	COG1053	succinate dehydrogenase
HIN88_RS03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HIN88_RS03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_RS03775	COG2354	Protein conserved in bacteria
HIN88_RS03780	COG2321	neutral zinc metallopeptidase
HIN88_RS03830	COG2843	Capsule synthesis protein
HIN88_RS03845	COG0589	response to stress
HIN88_RS03865	COG0505	Belongs to the CarA family
HIN88_RS03890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN88_RS03895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HIN88_RS03945	COG0477	Major facilitator Superfamily
HIN88_RS03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIN88_RS03965	COG1597	lipid kinase activity
HIN88_RS03970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN88_RS03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_RS03995	COG0584	glycerophosphoryl diester phosphodiesterase
HIN88_RS04015	COG0741	lytic transglycosylase activity
HIN88_RS04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIN88_RS04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_RS04085	COG0778	Nitroreductase
HIN88_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS04100	COG1929	Belongs to the glycerate kinase type-1 family
HIN88_RS04105	COG0243	molybdopterin cofactor binding
HIN88_RS04110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIN88_RS04115	COG3339	Conserved Protein
HIN88_RS04125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HIN88_RS04140	COG1113	amino acid transport
HIN88_RS04150	COG0019	diaminopimelate decarboxylase activity
HIN88_RS04160	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS04165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HIN88_RS04195	COG0463	Glycosyl transferase, family 2
HIN88_RS04215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS04245	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIN88_RS04250	COG1136	(ABC) transporter
HIN88_RS04255	COG2333	competence protein COMEC
HIN88_RS04255	COG0658	competence protein
HIN88_RS04265	COG0616	signal peptide processing
HIN88_RS04265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HIN88_RS04270	COG0596	Alpha beta hydrolase
HIN88_RS04275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIN88_RS04285	COG0628	permease
HIN88_RS04320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN88_RS04340	COG0823	Involved in the tonB-independent uptake of proteins
HIN88_RS04360	COG0824	Thioesterase
HIN88_RS04365	COG1473	amidohydrolase
HIN88_RS04385	COG0047	phosphoribosylformylglycinamidine synthase activity
HIN88_RS04385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIN88_RS04390	COG2814	Major facilitator Superfamily
HIN88_RS04400	COG1024	Enoyl-CoA hydratase
HIN88_RS04405	COG1056	cytidyltransferase-related domain
HIN88_RS04405	COG1051	belongs to the nudix hydrolase family
HIN88_RS04415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIN88_RS04430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HIN88_RS04445	COG4625	pathogenesis
HIN88_RS04450	COG0583	DNA-binding transcription factor activity
HIN88_RS04455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HIN88_RS04460	COG4208	sulfate ABC transporter
HIN88_RS04465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HIN88_RS04475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HIN88_RS04480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIN88_RS04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HIN88_RS04505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN88_RS04520	COG0681	Belongs to the peptidase S26 family
HIN88_RS04535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIN88_RS04545	COG1381	Involved in DNA repair and RecF pathway recombination
HIN88_RS04550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HIN88_RS04560	COG4221	oxidoreductase activity
HIN88_RS04590	COG0436	Aminotransferase
HIN88_RS04610	COG0556	nucleotide-excision repair
HIN88_RS04665	COG2070	2-Nitropropane dioxygenase
HIN88_RS04695	COG1215	transferase activity, transferring glycosyl groups
HIN88_RS04710	COG0415	Belongs to the DNA photolyase family
HIN88_RS04720	COG1252	NADH dehydrogenase
HIN88_RS04725	COG1686	Belongs to the peptidase S11 family
HIN88_RS04740	COG1187	pseudouridine synthase activity
HIN88_RS04840	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_RS05020	COG0582	viral genome integration into host DNA
HIN88_RS05045	COG0477	Major facilitator Superfamily
HIN88_RS05050	COG0583	DNA-binding transcription factor activity
HIN88_RS05065	COG0612	Peptidase, M16
HIN88_RS05090	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_RS05125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_RS05140	COG1309	transcriptional regulator
HIN88_RS05150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN88_RS05155	COG0076	glutamate decarboxylase activity
HIN88_RS05165	COG1522	sequence-specific DNA binding
HIN88_RS05170	COG3961	Belongs to the TPP enzyme family
HIN88_RS05175	COG1113	amino acid transport
HIN88_RS05180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HIN88_RS05185	COG0573	inorganic phosphate transmembrane transporter activity
HIN88_RS05195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HIN88_RS05200	COG0616	signal peptide processing
HIN88_RS05235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HIN88_RS05240	COG1686	Belongs to the peptidase S11 family
HIN88_RS05265	COG0583	DNA-binding transcription factor activity
HIN88_RS05270	COG1067	ATP-dependent peptidase activity
HIN88_RS05275	COG2211	Major facilitator Superfamily
HIN88_RS05295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HIN88_RS05315	COG1966	Carbon starvation protein
HIN88_RS05320	COG2879	small protein
HIN88_RS05350	COG1741	Belongs to the pirin family
HIN88_RS05360	COG2964	Protein conserved in bacteria
HIN88_RS05375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_RS05380	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIN88_RS05385	COG4605	iron ion homeostasis
HIN88_RS05390	COG4604	ABC transporter, ATP-binding protein
HIN88_RS05395	COG4607	ABC-type enterochelin transport system periplasmic component
HIN88_RS05400	COG4774	siderophore transport
HIN88_RS05410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_RS05415	COG1021	2,3-dihydroxybenzoate-AMP ligase
HIN88_RS05420	COG3433	isochorismatase activity
HIN88_RS05420	COG1535	isochorismatase
HIN88_RS05435	COG1132	(ABC) transporter
HIN88_RS05445	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HIN88_RS05455	COG1169	isochorismate synthase
HIN88_RS05470	COG3739	integral membrane protein
HIN88_RS05500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HIN88_RS05530	COG0308	aminopeptidase N
HIN88_RS05535	COG0512	Glutamine amidotransferase of anthranilate synthase
HIN88_RS05545	COG3104	oligopeptide transport
HIN88_RS05550	COG0174	glutamine synthetase
HIN88_RS05560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HIN88_RS05595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HIN88_RS05600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HIN88_RS05605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN88_RS05625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN88_RS05630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HIN88_RS05635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HIN88_RS05650	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS05655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN88_RS05660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_RS05670	COG2223	nitrite transmembrane transporter activity
HIN88_RS05680	COG0024	Methionine aminopeptidase
HIN88_RS05685	COG0052	Belongs to the universal ribosomal protein uS2 family
HIN88_RS05700	COG2207	Transcriptional regulator
HIN88_RS05725	COG2951	lytic endotransglycosylase activity
HIN88_RS05730	COG0772	Belongs to the SEDS family
HIN88_RS05745	COG0842	Transport permease protein
HIN88_RS05750	COG1131	(ABC) transporter
HIN88_RS05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS05805	COG4215	(ABC) transporter
HIN88_RS05810	COG4160	amino acid transport
HIN88_RS05815	COG4598	ABC transporter
HIN88_RS05825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN88_RS05835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_RS05850	COG1720	tRNA m6t6A37 methyltransferase activity
HIN88_RS05870	COG0745	RESPONSE REGULATOR receiver
HIN88_RS05875	COG0642	Histidine kinase
HIN88_RS05885	COG0494	nUDIX hydrolase
HIN88_RS05895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HIN88_RS05900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HIN88_RS05905	COG3139	Protein of unknown function (DUF1315)
HIN88_RS05910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIN88_RS05915	COG1301	dicarboxylic acid transport
HIN88_RS05920	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS05925	COG2819	hydrolase of the alpha beta superfamily
HIN88_RS05935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HIN88_RS05945	COG2195	Cleaves the N-terminal amino acid of tripeptides
HIN88_RS05950	COG1234	tRNA 3'-trailer cleavage
HIN88_RS05980	COG2363	Small membrane protein
HIN88_RS06000	COG0513	Belongs to the DEAD box helicase family
HIN88_RS06010	COG0778	Nitroreductase
HIN88_RS06040	COG1286	toxin biosynthetic process
HIN88_RS06065	COG4783	chaperone-mediated protein folding
HIN88_RS06070	COG1610	YqeY-like protein
HIN88_RS06100	COG2815	serine threonine protein kinase
HIN88_RS06100	COG0515	serine threonine protein kinase
HIN88_RS06125	COG2831	hemolysin activation secretion protein
HIN88_RS06245	COG3111	PFAM Bacterial OB fold (BOF) protein
HIN88_RS06275	COG0786	glutamate:sodium symporter activity
HIN88_RS06285	COG2186	Transcriptional regulator
HIN88_RS06365	COG2995	paraquat-inducible protein a
HIN88_RS06370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HIN88_RS06370	COG3008	intermembrane lipid transfer
HIN88_RS06380	COG2351	hydroxyisourate hydrolase activity
HIN88_RS06395	COG5002	protein histidine kinase activity
HIN88_RS06420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN88_RS06430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN88_RS06435	COG0642	Histidine kinase
HIN88_RS06440	COG0745	RESPONSE REGULATOR receiver
HIN88_RS06460	COG1794	racemase activity, acting on amino acids and derivatives
HIN88_RS06490	COG1301	dicarboxylic acid transport
HIN88_RS06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_RS06505	COG2011	ABC-type metal ion transport system permease component
HIN88_RS06510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIN88_RS06515	COG1464	Belongs to the NlpA lipoprotein family
HIN88_RS06520	COG0151	Belongs to the GarS family
HIN88_RS06525	COG0138	bifunctional purine biosynthesis protein purh
HIN88_RS06530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HIN88_RS06560	COG2308	Evidence 4 Homologs of previously reported genes of
HIN88_RS06570	COG1305	Transglutaminase-like
HIN88_RS06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIN88_RS06585	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_RS06610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HIN88_RS06620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HIN88_RS06625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIN88_RS06650	COG1649	PFAM Uncharacterised BCR, COG1649
HIN88_RS06650	COG0726	polysaccharide deacetylase
HIN88_RS06655	COG1215	transferase activity, transferring glycosyl groups
HIN88_RS06660	COG3658	cytochrome
HIN88_RS06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS06700	COG2890	protein-(glutamine-N5) methyltransferase activity
HIN88_RS06705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS06710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_RS06725	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS06730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_RS06735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_RS06760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HIN88_RS06765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HIN88_RS06770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HIN88_RS06775	COG2205	protein histidine kinase activity
HIN88_RS06780	COG0745	RESPONSE REGULATOR receiver
HIN88_RS06785	COG0174	glutamine synthetase
HIN88_RS06805	COG0729	surface antigen
HIN88_RS06830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_RS06835	COG2814	Major facilitator Superfamily
HIN88_RS06850	COG0583	DNA-binding transcription factor activity
HIN88_RS06865	COG1187	pseudouridine synthase activity
HIN88_RS06885	COG0802	atpase or kinase
HIN88_RS06890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HIN88_RS06900	COG1923	regulation of RNA biosynthetic process
HIN88_RS06905	COG0697	spore germination
HIN88_RS06930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN88_RS06935	COG0519	Catalyzes the synthesis of GMP from XMP
HIN88_RS06935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN88_RS06940	COG4302	ethanolamine ammonia-lyase activity
HIN88_RS06945	COG4303	Ethanolamine ammonia lyase large subunit
HIN88_RS06950	COG0531	amino acid
HIN88_RS06970	COG1454	alcohol dehydrogenase
HIN88_RS06975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_RS06985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HIN88_RS07005	COG0308	aminopeptidase N
HIN88_RS07045	COG1605	Chorismate mutase
HIN88_RS07060	COG1309	transcriptional regulator
HIN88_RS07070	COG0668	transmembrane transport
HIN88_RS07100	COG4773	Receptor
HIN88_RS07120	COG0488	(ABC) transporter
HIN88_RS07125	COG0589	response to stress
HIN88_RS07150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HIN88_RS07160	COG3135	benzoate transporter
HIN88_RS07165	COG1522	sequence-specific DNA binding
HIN88_RS07175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HIN88_RS07180	COG0583	DNA-binding transcription factor activity
HIN88_RS07190	COG0183	Belongs to the thiolase family
HIN88_RS07200	COG2030	dehydratase
HIN88_RS07220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIN88_RS07230	COG0824	Thioesterase
HIN88_RS07235	COG1454	alcohol dehydrogenase
HIN88_RS07245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIN88_RS07265	COG0069	glutamate synthase activity
HIN88_RS07285	COG2814	Major facilitator Superfamily
HIN88_RS07300	COG0511	ligase activity, forming carbon-carbon bonds
HIN88_RS07320	COG1116	anion transmembrane transporter activity
HIN88_RS07320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_RS07325	COG0745	RESPONSE REGULATOR receiver
HIN88_RS07335	COG2146	nitrite reductase [NAD(P)H] activity
HIN88_RS07335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_RS07340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_RS07345	COG0243	molybdopterin cofactor binding
HIN88_RS07355	COG0243	molybdopterin cofactor binding
HIN88_RS07360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HIN88_RS07375	COG0315	cyclic pyranopterin monophosphate synthase activity
HIN88_RS07375	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIN88_RS07380	COG0303	'Molybdopterin
HIN88_RS07395	COG0697	spore germination
HIN88_RS07415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HIN88_RS07420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN88_RS07475	COG2204	response regulator
HIN88_RS07480	COG3852	Histidine kinase
HIN88_RS07500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIN88_RS07505	COG0575	Belongs to the CDS family
HIN88_RS07520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN88_RS07540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN88_RS07555	COG2137	regulation of response to DNA damage stimulus
HIN88_RS07565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HIN88_RS07570	COG1011	Hydrolase
HIN88_RS07595	COG1522	sequence-specific DNA binding
HIN88_RS07605	COG1113	amino acid transport
HIN88_RS07620	COG0659	secondary active sulfate transmembrane transporter activity
HIN88_RS07625	COG2135	peptidase activity
HIN88_RS07640	COG3300	MHYT domain
HIN88_RS07640	COG5001	Diguanylate cyclase
HIN88_RS07655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN88_RS07655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN88_RS07655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HIN88_RS07660	COG1105	Belongs to the carbohydrate kinase PfkB family
HIN88_RS07665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN88_RS07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIN88_RS07695	COG0024	Methionine aminopeptidase
HIN88_RS07700	COG0583	DNA-binding transcription factor activity
HIN88_RS07710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIN88_RS07715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN88_RS07720	COG0516	GMP reductase activity
HIN88_RS07720	COG0517	IMP dehydrogenase activity
HIN88_RS07745	COG0552	protein localization to endoplasmic reticulum
HIN88_RS07755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HIN88_RS07770	COG4890	Cyd operon protein YbgT
HIN88_RS07775	COG1294	oxidase, subunit
HIN88_RS07790	COG1585	Membrane protein implicated in regulation of membrane protease activity
HIN88_RS07800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIN88_RS07805	COG4774	siderophore transport
HIN88_RS07820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HIN88_RS07825	COG0569	domain protein
HIN88_RS07830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN88_RS07860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HIN88_RS07865	COG0542	response to heat
HIN88_RS07890	COG1902	pentaerythritol trinitrate reductase activity
HIN88_RS07890	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_RS07935	COG2323	membrane
HIN88_RS07940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HIN88_RS07950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_RS07955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_RS07960	COG0183	Belongs to the thiolase family
HIN88_RS07965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIN88_RS07970	COG0596	Alpha beta hydrolase
HIN88_RS07975	COG2271	Major facilitator Superfamily
HIN88_RS07980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIN88_RS07985	COG3485	protocatechuate 3,4-dioxygenase
HIN88_RS07990	COG3485	protocatechuate 3,4-dioxygenase
HIN88_RS07995	COG0710	3-dehydroquinate dehydratase activity
HIN88_RS08000	COG3420	alginic acid biosynthetic process
HIN88_RS08005	COG3659	wide pore channel activity
HIN88_RS08010	COG4993	Dehydrogenase
HIN88_RS08020	COG2391	methyltransferase activity
HIN88_RS08035	COG1414	Transcriptional regulator
HIN88_RS08040	COG0583	DNA-binding transcription factor activity
HIN88_RS08045	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS08070	COG2814	Major facilitator Superfamily
HIN88_RS08080	COG0154	amidase activity
HIN88_RS08100	COG4638	Rieske (2fe-2S)
HIN88_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS08120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_RS08130	COG3733	amine oxidase
HIN88_RS08140	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_RS08150	COG0183	Belongs to the thiolase family
HIN88_RS08155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_RS08160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_RS08170	COG4829	muconolactone delta-isomerase
HIN88_RS08175	COG4948	Mandelate Racemase Muconate Lactonizing
HIN88_RS08180	COG0583	DNA-binding transcription factor activity
HIN88_RS08190	COG2186	Transcriptional regulator
HIN88_RS08210	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS08215	COG3231	kanamycin kinase activity
HIN88_RS08230	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS08240	COG3829	transcription factor binding
HIN88_RS08250	COG3162	membrane
HIN88_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS08280	COG0753	catalase activity
HIN88_RS08305	COG1846	Transcriptional regulator
HIN88_RS08310	COG1902	pentaerythritol trinitrate reductase activity
HIN88_RS08310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_RS08320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HIN88_RS08350	COG1309	transcriptional regulator
HIN88_RS08355	COG0583	DNA-binding transcription factor activity
HIN88_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS08380	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_RS08455	COG2188	Transcriptional regulator
HIN88_RS08470	COG0583	DNA-binding transcription factor activity
HIN88_RS08500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_RS08510	COG1566	PFAM secretion protein HlyD family protein
HIN88_RS08525	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS08530	COG0129	dihydroxy-acid dehydratase activity
HIN88_RS08540	COG0583	DNA-binding transcription factor activity
HIN88_RS08545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIN88_RS08555	COG2084	Dehydrogenase
HIN88_RS08560	COG2207	Transcriptional regulator
HIN88_RS08565	COG1064	alcohol dehydrogenase
HIN88_RS08580	COG1120	ATPase activity
HIN88_RS08600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN88_RS08650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HIN88_RS08680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_RS08715	COG1073	alpha beta
HIN88_RS08725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIN88_RS08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_RS08760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS08765	COG0745	RESPONSE REGULATOR receiver
HIN88_RS08770	COG2205	protein histidine kinase activity
HIN88_RS08785	COG2072	flavoprotein involved in K transport
HIN88_RS08865	COG2175	clavaminate synthase activity
HIN88_RS08870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_RS08885	COG0667	Aldo Keto reductase
HIN88_RS08890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS08905	COG2175	clavaminate synthase activity
HIN88_RS08935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS08940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS08945	COG4771	TonB-dependent receptor
HIN88_RS08975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS08980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_RS08985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS08990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS09005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIN88_RS09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS09040	COG1132	(ABC) transporter
HIN88_RS09045	COG1132	(ABC) transporter
HIN88_RS09065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIN88_RS09070	COG0601	transmembrane transport
HIN88_RS09100	COG3539	Fimbrial protein
HIN88_RS09125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HIN88_RS09135	COG0753	catalase activity
HIN88_RS09150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN88_RS09215	COG3433	isochorismatase activity
HIN88_RS09215	COG1535	isochorismatase
HIN88_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS09225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HIN88_RS09230	COG4149	molybdate abc transporter
HIN88_RS09235	COG0725	ABC transporter, periplasmic molybdate-binding protein
HIN88_RS09245	COG4638	Rieske (2fe-2S)
HIN88_RS09250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN88_RS09255	COG0543	2 iron, 2 sulfur cluster binding
HIN88_RS09255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_RS09270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS09295	COG2207	Transcriptional regulator
HIN88_RS09300	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS09305	COG2610	gluconate transmembrane transporter activity
HIN88_RS09315	COG0583	DNA-binding transcription factor activity
HIN88_RS09330	COG2031	fatty acid transporter
HIN88_RS09335	COG0183	Belongs to the thiolase family
HIN88_RS09340	COG0583	DNA-binding transcription factor activity
HIN88_RS09345	COG0583	DNA-binding transcription factor activity
HIN88_RS09360	COG1027	Aspartate ammonia-lyase
HIN88_RS09370	COG0477	Major facilitator Superfamily
HIN88_RS09390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS09395	COG4521	taurine ABC transporter
HIN88_RS09410	COG2188	Transcriptional regulator
HIN88_RS09420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HIN88_RS09425	COG1733	regulation of RNA biosynthetic process
HIN88_RS09430	COG3708	Transcriptional regulator
HIN88_RS09430	COG2207	Transcriptional regulator
HIN88_RS09445	COG0730	response to heat
HIN88_RS09455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_RS09455	COG3453	Protein conserved in bacteria
HIN88_RS09465	COG3781	membrane
HIN88_RS09470	COG1063	alcohol dehydrogenase
HIN88_RS09480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_RS09485	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN88_RS09490	COG0022	dehydrogenase e1 component
HIN88_RS09495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIN88_RS09500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN88_RS09515	COG3706	GGDEF domain
HIN88_RS09530	COG0133	tryptophan synthase activity
HIN88_RS09540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN88_RS09575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIN88_RS09600	COG2226	methyltransferase
HIN88_RS09655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN88_RS09660	COG4773	Receptor
HIN88_RS09680	COG0730	response to heat
HIN88_RS09685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HIN88_RS09700	COG0406	alpha-ribazole phosphatase activity
HIN88_RS09705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HIN88_RS09720	COG0246	Mannitol dehydrogenase
HIN88_RS09750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_RS09760	COG4264	IucA IucC family
HIN88_RS09765	COG4264	IucA IucC family
HIN88_RS09785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIN88_RS09800	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS09805	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS09810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_RS09815	COG2207	Transcriptional regulator
HIN88_RS09820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN88_RS09825	COG0776	regulation of translation
HIN88_RS09850	COG0822	iron-sulfur transferase activity
HIN88_RS09855	COG0316	Belongs to the HesB IscA family
HIN88_RS09885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIN88_RS09905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_RS09910	COG0702	epimerase
HIN88_RS09945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIN88_RS09955	COG0339	signal peptide processing
HIN88_RS10005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HIN88_RS10010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HIN88_RS10040	COG0776	regulation of translation
HIN88_RS10105	COG0084	hydrolase, TatD family'
HIN88_RS10125	COG1663	tetraacyldisaccharide 4'-kinase activity
HIN88_RS10130	COG1132	(ABC) transporter
HIN88_RS10140	COG0811	peptide transport
HIN88_RS10145	COG1475	DNA binding
HIN88_RS10150	COG1192	Involved in chromosome partitioning
HIN88_RS10160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HIN88_RS10175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN88_RS10180	COG0191	fructose-bisphosphate aldolase activity
HIN88_RS10200	COG0424	maF-like protein
HIN88_RS10205	COG2850	peptidyl-arginine hydroxylation
HIN88_RS10215	COG0640	Transcriptional regulator
HIN88_RS10225	COG3619	membrane
HIN88_RS10230	COG3122	Protein conserved in bacteria
HIN88_RS10235	COG1132	(ABC) transporter
HIN88_RS10255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HIN88_RS10260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN88_RS10270	COG0506	proline dehydrogenase activity
HIN88_RS10270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN88_RS10270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN88_RS10275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HIN88_RS10290	COG3698	Phosphodiester glycosidase
HIN88_RS10300	COG2353	YceI-like domain
HIN88_RS10310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIN88_RS10380	COG3539	Fimbrial protein
HIN88_RS10385	COG3121	Chaperone
HIN88_RS10410	COG0697	spore germination
HIN88_RS10420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HIN88_RS10430	COG0583	DNA-binding transcription factor activity
HIN88_RS10450	COG1309	transcriptional regulator
HIN88_RS10465	COG1522	sequence-specific DNA binding
HIN88_RS10475	COG1126	abc transporter atp-binding protein
HIN88_RS10480	COG0765	amino acid transport
HIN88_RS10485	COG0765	amino acid transport
HIN88_RS10515	COG1464	Belongs to the NlpA lipoprotein family
HIN88_RS10525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIN88_RS10530	COG2011	ABC-type metal ion transport system permease component
HIN88_RS10535	COG0012	GTP binding
HIN88_RS10560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN88_RS10600	COG0386	Belongs to the glutathione peroxidase family
HIN88_RS10610	COG0436	Aminotransferase
HIN88_RS10650	COG3634	alkyl hydroperoxide reductase activity
HIN88_RS10665	COG0583	DNA-binding transcription factor activity
HIN88_RS10670	COG0798	PFAM Bile acid sodium symporter
HIN88_RS10675	COG0640	Transcriptional regulator
HIN88_RS10690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HIN88_RS10700	COG0583	DNA-binding transcription factor activity
HIN88_RS10710	COG1953	Uracil, thiamine, allantoin
HIN88_RS10720	COG2175	clavaminate synthase activity
HIN88_RS10725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS10730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HIN88_RS10735	COG4521	taurine ABC transporter
HIN88_RS10745	COG0477	Major facilitator Superfamily
HIN88_RS10765	COG1271	oxidase subunit
HIN88_RS10770	COG1294	oxidase, subunit
HIN88_RS10780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_RS10800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HIN88_RS10820	COG3052	prosthetic group binding
HIN88_RS10825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HIN88_RS10835	COG2814	Major facilitator Superfamily
HIN88_RS10855	COG1346	cytolysis
HIN88_RS10865	COG0583	DNA-binding transcription factor activity
HIN88_RS10870	COG0625	glutathione transferase activity
HIN88_RS10875	COG0625	glutathione transferase activity
HIN88_RS10880	COG0583	DNA-binding transcription factor activity
HIN88_RS10895	COG1045	serine acetyltransferase
HIN88_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_RS10905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIN88_RS10910	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS10925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN88_RS10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN88_RS10935	COG1126	abc transporter atp-binding protein
HIN88_RS10940	COG0765	amino acid transport
HIN88_RS10945	COG0765	amino acid transport
HIN88_RS11000	COG0784	Response regulator, receiver
HIN88_RS11000	COG2205	protein histidine kinase activity
HIN88_RS11040	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS11090	COG0583	DNA-binding transcription factor activity
HIN88_RS11110	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_RS11115	COG1309	transcriptional regulator
HIN88_RS11120	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS11125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN88_RS11130	COG1024	Enoyl-CoA hydratase
HIN88_RS11135	COG4770	biotin carboxylase activity
HIN88_RS11145	COG0583	DNA-binding transcription factor activity
HIN88_RS11160	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS11170	COG2814	Major facilitator Superfamily
HIN88_RS11180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_RS11185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_RS11190	COG2814	Major facilitator Superfamily
HIN88_RS11195	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS11200	COG1024	Enoyl-CoA hydratase
HIN88_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS11210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_RS11215	COG0183	Belongs to the thiolase family
HIN88_RS11225	COG2814	Major facilitator Superfamily
HIN88_RS11235	COG1024	Enoyl-CoA hydratase
HIN88_RS11265	COG1063	alcohol dehydrogenase
HIN88_RS11270	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_RS11290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HIN88_RS11300	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS11305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_RS11310	COG2271	Major facilitator Superfamily
HIN88_RS11320	COG2186	Transcriptional regulator
HIN88_RS11345	COG0038	chloride channel
HIN88_RS11350	COG4770	biotin carboxylase activity
HIN88_RS11370	COG1914	H( )-stimulated, divalent metal cation uptake system
HIN88_RS11375	COG0583	DNA-binding transcription factor activity
HIN88_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_RS11430	COG2814	Major facilitator Superfamily
HIN88_RS11460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HIN88_RS11470	COG4122	O-methyltransferase activity
HIN88_RS11500	COG1538	Outer membrane efflux protein
HIN88_RS11510	COG1137	ATPase activity
HIN88_RS11515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HIN88_RS11525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HIN88_RS11575	COG2814	Major facilitator Superfamily
HIN88_RS11610	COG1278	Cold shock
HIN88_RS11615	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS11650	COG1570	exodeoxyribonuclease VII activity
HIN88_RS11700	COG0583	DNA-binding transcription factor activity
HIN88_RS11705	COG4638	Rieske (2fe-2S)
HIN88_RS11710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN88_RS11715	COG0543	2 iron, 2 sulfur cluster binding
HIN88_RS11715	COG0633	Ferredoxin
HIN88_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS11725	COG3135	benzoate transporter
HIN88_RS11730	COG2814	Major facilitator Superfamily
HIN88_RS11745	COG1643	Atp-dependent helicase
HIN88_RS11750	COG0450	alkyl hydroperoxide reductase
HIN88_RS11760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HIN88_RS11770	COG3634	alkyl hydroperoxide reductase activity
HIN88_RS11790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HIN88_RS11795	COG0625	glutathione transferase activity
HIN88_RS11805	COG2885	chlorophyll binding
HIN88_RS11840	COG0542	response to heat
HIN88_RS11855	COG1765	OsmC-like protein
HIN88_RS11865	COG0667	Aldo Keto reductase
HIN88_RS11880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIN88_RS11890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HIN88_RS11900	COG0582	viral genome integration into host DNA
HIN88_RS11905	COG2194	sulfuric ester hydrolase activity
HIN88_RS11945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN88_RS11970	COG2314	TM2 domain
HIN88_RS12025	COG3566	protein conserved in bacteria
HIN88_RS12040	COG3567	Phage-associated protein, HI1409 family
HIN88_RS12045	COG5410	chromosome segregation
HIN88_RS12145	COG4197	protein conserved in bacteria, prophage-related
HIN88_RS12150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN88_RS12205	COG0527	aspartate kinase activity
HIN88_RS12215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIN88_RS12225	COG3038	cytochrome b561
HIN88_RS12230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HIN88_RS12235	COG2252	PERMEase
HIN88_RS12245	COG2072	flavoprotein involved in K transport
HIN88_RS12260	COG1741	Belongs to the pirin family
HIN88_RS12265	COG1309	transcriptional regulator
HIN88_RS12275	COG0300	oxidoreductase activity
HIN88_RS12280	COG2072	flavoprotein involved in K transport
HIN88_RS12285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HIN88_RS12290	COG0583	DNA-binding transcription factor activity
HIN88_RS12305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_RS12350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HIN88_RS12365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_RS12380	COG2814	Major facilitator Superfamily
HIN88_RS12385	COG1024	Enoyl-CoA hydratase
HIN88_RS12390	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS12400	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS12425	COG2186	Transcriptional regulator
HIN88_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS12440	COG4948	Mandelate Racemase Muconate Lactonizing
HIN88_RS12445	COG2271	Major facilitator Superfamily
HIN88_RS12450	COG2721	sulfolactate sulfo-lyase activity
HIN88_RS12455	COG0697	spore germination
HIN88_RS12485	COG3210	domain, Protein
HIN88_RS12490	COG2831	hemolysin activation secretion protein
HIN88_RS12495	COG1113	amino acid transport
HIN88_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS12535	COG0531	amino acid
HIN88_RS12545	COG1113	amino acid transport
HIN88_RS12590	COG4269	membrane
HIN88_RS12605	COG1902	pentaerythritol trinitrate reductase activity
HIN88_RS12605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_RS12615	COG3706	GGDEF domain
HIN88_RS12615	COG4251	negative regulation of phosphorylation
HIN88_RS12615	COG2203	Gaf domain
HIN88_RS12615	COG5001	Diguanylate cyclase
HIN88_RS12625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN88_RS12650	COG4172	Belongs to the ABC transporter superfamily
HIN88_RS12655	COG4239	(ABC) transporter, permease
HIN88_RS12660	COG4174	ABC transporter (Permease)
HIN88_RS12670	COG1388	LysM domain
HIN88_RS12670	COG0741	lytic transglycosylase activity
HIN88_RS12670	COG1388	LysM domain
HIN88_RS12670	COG0741	lytic transglycosylase activity
HIN88_RS12675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN88_RS12715	COG0583	DNA-binding transcription factor activity
HIN88_RS12720	COG1279	arginine transmembrane transporter activity
HIN88_RS12740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_RS12745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_RS12750	COG0006	proline dipeptidase activity
HIN88_RS12840	COG0739	heme binding
HIN88_RS12840	COG0741	lytic transglycosylase activity
HIN88_RS12840	COG1196	nuclear chromosome segregation
HIN88_RS12900	COG4695	Portal protein
HIN88_RS13000	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_RS13280	COG5410	chromosome segregation
HIN88_RS13380	COG3620	sequence-specific DNA binding
HIN88_RS13455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIN88_RS13480	COG3384	dioxygenase
HIN88_RS13490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN88_RS13495	COG2878	Part of a membrane complex involved in electron transport
HIN88_RS13500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIN88_RS13525	COG0768	penicillin binding
HIN88_RS13530	COG0742	ribosomal rna small subunit methyltransferase
HIN88_RS13545	COG0830	nickel cation binding
HIN88_RS13555	COG0804	urea catabolic process
HIN88_RS13600	COG1253	flavin adenine dinucleotide binding
HIN88_RS13605	COG2851	Citrate transporter
HIN88_RS13655	COG1773	rubredoxin
HIN88_RS13660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_RS13670	COG0583	DNA-binding transcription factor activity
HIN88_RS13700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HIN88_RS13705	COG4181	ATPase activity
HIN88_RS13750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HIN88_RS13770	COG0306	phosphate transporter
HIN88_RS13780	COG3958	Transketolase
HIN88_RS13785	COG3959	Transketolase, thiamine diphosphate binding domain
HIN88_RS13790	COG2271	Major facilitator Superfamily
HIN88_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS13800	COG0583	DNA-binding transcription factor activity
HIN88_RS13815	COG2223	nitrite transmembrane transporter activity
HIN88_RS13820	COG2207	Transcriptional regulator
HIN88_RS13825	COG2066	Belongs to the glutaminase family
HIN88_RS13830	COG0242	peptide deformylase activity
HIN88_RS13835	COG0477	Major facilitator Superfamily
HIN88_RS13845	COG0028	Belongs to the TPP enzyme family
HIN88_RS13850	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS13860	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS13865	COG2267	carboxylic ester hydrolase activity
HIN88_RS13875	COG2271	Major facilitator Superfamily
HIN88_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS13910	COG1414	Transcriptional regulator
HIN88_RS13925	COG1024	Enoyl-CoA hydratase
HIN88_RS13935	COG1215	transferase activity, transferring glycosyl groups
HIN88_RS13940	COG1649	PFAM Uncharacterised BCR, COG1649
HIN88_RS13940	COG0726	polysaccharide deacetylase
HIN88_RS13950	COG4681	YaeQ
HIN88_RS13960	COG0523	cobalamin synthesis protein
HIN88_RS13970	COG1607	acyl-coa hydrolase
HIN88_RS13980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_RS13985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_RS13990	COG1309	transcriptional regulator
HIN88_RS14015	COG2040	homocysteine
HIN88_RS14020	COG0531	amino acid
HIN88_RS14045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_RS14050	COG0477	Major facilitator Superfamily
HIN88_RS14140	COG0582	viral genome integration into host DNA
HIN88_RS14150	COG0405	Gamma-glutamyltransferase
HIN88_RS14155	COG2814	Major facilitator Superfamily
HIN88_RS14165	COG2050	protein possibly involved in aromatic compounds catabolism
HIN88_RS14180	COG1090	epimerase
HIN88_RS14200	COG0420	3'-5' exonuclease activity
HIN88_RS14225	COG0735	belongs to the Fur family
HIN88_RS14230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN88_RS14250	COG0121	glutamine amidotransferase
HIN88_RS14265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN88_RS14275	COG0210	DNA helicase
HIN88_RS14280	COG2885	chlorophyll binding
HIN88_RS14285	COG0204	Acyl-transferase
HIN88_RS14300	COG2894	cell division
HIN88_RS14315	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS14320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HIN88_RS14320	COG1674	ftsk spoiiie
HIN88_RS14325	COG0492	ferredoxin-NADP+ reductase activity
HIN88_RS14330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HIN88_RS14340	COG0456	acetyltransferase
HIN88_RS14400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN88_RS14400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HIN88_RS14420	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS14440	COG0473	3-isopropylmalate dehydrogenase activity
HIN88_RS14445	COG0583	DNA-binding transcription factor activity
HIN88_RS14465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN88_RS14490	COG0564	pseudouridine synthase activity
HIN88_RS14500	COG0358	DNA primase activity
HIN88_RS14515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HIN88_RS14545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN88_RS14575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIN88_RS14585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN88_RS14585	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_RS14585	COG0351	phosphomethylpyrimidine kinase
HIN88_RS14590	COG1652	LysM domain
HIN88_RS14615	COG1399	metal-binding, possibly nucleic acid-binding protein
HIN88_RS14620	COG3101	peptidyl-lysine hydroxylation
HIN88_RS14625	COG0009	L-threonylcarbamoyladenylate synthase
HIN88_RS14630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIN88_RS14635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIN88_RS14650	COG4106	trans-aconitate 2-methyltransferase activity
HIN88_RS14665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_RS14665	COG2226	methyltransferase
HIN88_RS14665	COG0596	Alpha beta hydrolase
HIN88_RS14670	COG1877	trehalose-phosphatase activity
HIN88_RS14675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HIN88_RS14680	COG2223	nitrite transmembrane transporter activity
HIN88_RS14700	COG1196	nuclear chromosome segregation
HIN88_RS14710	COG0730	response to heat
HIN88_RS14725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIN88_RS14735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN88_RS14785	COG0489	protein tyrosine kinase activity
HIN88_RS14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_RS14795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_RS14825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HIN88_RS14830	COG2081	HI0933 family
HIN88_RS14840	COG0668	transmembrane transport
HIN88_RS14860	COG0583	DNA-binding transcription factor activity
HIN88_RS14880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIN88_RS14885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN88_RS14915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIN88_RS14950	COG2205	protein histidine kinase activity
HIN88_RS14955	COG0745	RESPONSE REGULATOR receiver
HIN88_RS14975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIN88_RS15040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_RS15065	COG1473	amidohydrolase
HIN88_RS15075	COG0583	DNA-binding transcription factor activity
HIN88_RS15090	COG0583	DNA-binding transcription factor activity
HIN88_RS15095	COG1053	succinate dehydrogenase
HIN88_RS15105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HIN88_RS15110	COG2814	Major facilitator Superfamily
HIN88_RS15115	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS15120	COG0583	DNA-binding transcription factor activity
HIN88_RS15125	COG1063	alcohol dehydrogenase
HIN88_RS15155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HIN88_RS15160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HIN88_RS15165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN88_RS15180	COG3667	copper resistance
HIN88_RS15185	COG2132	Multicopper oxidase
HIN88_RS15195	COG0561	phosphatase activity
HIN88_RS15200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIN88_RS15225	COG1214	PFAM Peptidase M22, glycoprotease
HIN88_RS15275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HIN88_RS15285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIN88_RS15290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HIN88_RS15295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIN88_RS15355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN88_RS15365	COG1846	Transcriptional regulator
HIN88_RS15370	COG1764	response to oxidative stress
HIN88_RS15410	COG0037	tRNA processing
HIN88_RS15420	COG0248	Ppx GppA phosphatase
HIN88_RS15450	COG0072	phenylalanine-tRNA ligase activity
HIN88_RS15490	COG1238	metal cluster binding
HIN88_RS15495	COG0625	glutathione transferase activity
HIN88_RS15510	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_RS15515	COG3028	Belongs to the UPF0307 family
HIN88_RS15520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN88_RS15540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIN88_RS15545	COG0617	tRNA 3'-terminal CCA addition
HIN88_RS15550	COG1555	photosystem II stabilization
HIN88_RS15555	COG3956	TIGRFAM MazG family protein
HIN88_RS15565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN88_RS15585	COG0784	Response regulator, receiver
HIN88_RS15585	COG2205	protein histidine kinase activity
HIN88_RS15585	COG5002	protein histidine kinase activity
HIN88_RS15590	COG1024	Enoyl-CoA hydratase
HIN88_RS15595	COG2084	Dehydrogenase
HIN88_RS15600	COG3622	Belongs to the hyi family
HIN88_RS15630	COG0697	spore germination
HIN88_RS15640	COG2814	Major facilitator Superfamily
HIN88_RS15645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN88_RS15655	COG0583	DNA-binding transcription factor activity
HIN88_RS15665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HIN88_RS15675	COG0084	hydrolase, TatD family'
HIN88_RS15690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HIN88_RS15720	COG0440	acetolactate synthase activity
HIN88_RS15725	COG0028	Belongs to the TPP enzyme family
HIN88_RS15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_RS15755	COG0577	efflux transmembrane transporter activity
HIN88_RS15755	COG1136	(ABC) transporter
HIN88_RS15775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HIN88_RS15780	COG1162	GTPase activity
HIN88_RS15790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HIN88_RS15830	COG1426	Protein conserved in bacteria
HIN88_RS15865	COG0793	Belongs to the peptidase S41A family
HIN88_RS15880	COG2267	carboxylic ester hydrolase activity
HIN88_RS15890	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_RS15895	COG3265	gluconokinase activity
HIN88_RS15905	COG0800	Aldolase
HIN88_RS15915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIN88_RS15920	COG0857	belongs to the CobB CobQ family
HIN88_RS15920	COG0280	phosphate acetyltransferase
HIN88_RS15925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_RS15925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_RS15945	COG0740	serine-type endopeptidase activity
HIN88_RS15955	COG4774	siderophore transport
HIN88_RS15965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIN88_RS15975	COG2813	Specifically methylates the guanine in position
HIN88_RS15975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_RS16075	COG0788	formyltetrahydrofolate deformylase activity
HIN88_RS16100	COG4651	solute:proton antiporter activity
HIN88_RS16100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN88_RS16120	COG0724	RNA recognition motif
HIN88_RS16125	COG0210	DNA helicase
HIN88_RS16150	COG1733	regulation of RNA biosynthetic process
HIN88_RS16160	COG2900	Belongs to the SlyX family
HIN88_RS16175	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS16180	COG1560	Kdo2-lipid A biosynthetic process
HIN88_RS16190	COG1301	dicarboxylic acid transport
HIN88_RS16245	COG0473	3-isopropylmalate dehydrogenase activity
HIN88_RS16300	COG0583	DNA-binding transcription factor activity
HIN88_RS16310	COG0625	glutathione transferase activity
HIN88_RS16315	COG2378	regulation of single-species biofilm formation
HIN88_RS16320	COG0546	phosphoglycolate phosphatase activity
HIN88_RS16335	COG1530	ribonuclease E activity
HIN88_RS16340	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_RS16355	COG0583	DNA-binding transcription factor activity
HIN88_RS16360	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS16365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIN88_RS16375	COG0534	Mate efflux family protein
HIN88_RS16390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HIN88_RS16430	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HIN88_RS16435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_RS16450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN88_RS16460	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HIN88_RS16460	COG0644	oxidoreductase
HIN88_RS16470	COG0425	Belongs to the sulfur carrier protein TusA family
HIN88_RS16475	COG4535	Mg2 and Co2 transporter CorC
HIN88_RS16485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_RS16505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIN88_RS16510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN88_RS16510	COG0475	glutathione-regulated potassium exporter activity
HIN88_RS16525	COG0484	heat shock protein binding
HIN88_RS16530	COG0789	Transcriptional regulator
HIN88_RS16535	COG0598	Magnesium transport protein CorA
HIN88_RS16555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_RS16560	COG1074	ATP-dependent DNA helicase activity
HIN88_RS16565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HIN88_RS16585	COG2226	methyltransferase
HIN88_RS16615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIN88_RS16630	COG2111	Na H antiporter
HIN88_RS16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN88_RS16635	COG1006	Multisubunit Na H antiporter MnhC subunit
HIN88_RS16640	COG0651	ATP synthesis coupled electron transport
HIN88_RS16650	COG2212	antiporter activity
HIN88_RS16670	COG0195	Participates in both transcription termination and antitermination
HIN88_RS16720	COG0237	dephospho-CoA kinase activity
HIN88_RS16730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN88_RS16745	COG0497	DNA recombination
HIN88_RS16755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIN88_RS16785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN88_RS16785	COG2169	Transcriptional regulator
HIN88_RS16790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIN88_RS16855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HIN88_RS16870	COG0326	Molecular chaperone. Has ATPase activity
HIN88_RS16885	COG2056	Na+-H+ antiporter family
HIN88_RS16890	COG0596	Alpha beta hydrolase
HIN88_RS16985	COG0546	phosphoglycolate phosphatase activity
HIN88_RS16990	COG1716	ATPase activity
HIN88_RS17035	COG0181	hydroxymethylbilane synthase activity
HIN88_RS17045	COG3275	phosphorelay sensor kinase activity
HIN88_RS17065	COG1538	Outer membrane efflux protein
HIN88_RS17070	COG0697	spore germination
HIN88_RS17095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN88_RS17100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HIN88_RS17105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN88_RS17110	COG0772	Belongs to the SEDS family
HIN88_RS17135	COG4974	Belongs to the 'phage' integrase family
HIN88_RS17140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_RS17150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HIN88_RS17160	COG2197	response regulator
HIN88_RS17175	COG0793	Belongs to the peptidase S41A family
HIN88_RS17180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIN88_RS17185	COG0795	lipopolysaccharide-transporting ATPase activity
HIN88_RS17225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN88_RS17225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN88_RS17235	COG0004	ammonium transporteR
HIN88_RS17240	COG0347	Belongs to the P(II) protein family
HIN88_RS17250	COG0606	chelatase, subunit chli
HIN88_RS17280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HIN88_RS17325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_RS17350	COG2132	Multicopper oxidase
HIN88_RS17365	COG2205	protein histidine kinase activity
HIN88_RS17370	COG2217	Heavy metal translocating P-type atpase
HIN88_RS17420	COG0606	chelatase, subunit chli
HIN88_RS17425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_RS17430	COG0235	Class ii aldolase
HIN88_RS17435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_RS17450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HIN88_RS17465	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_RS17475	COG0477	Major facilitator Superfamily
HIN88_RS17480	COG2860	membrane
HIN88_RS17490	COG1253	flavin adenine dinucleotide binding
HIN88_RS17500	COG0477	Major facilitator Superfamily
HIN88_RS17510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN88_RS17545	COG0655	NAD(P)H dehydrogenase (quinone) activity
HIN88_RS17555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HIN88_RS17590	COG1309	transcriptional regulator
HIN88_RS17625	COG0758	DNA mediated transformation
HIN88_RS17635	COG0697	spore germination
HIN88_RS17640	COG1309	transcriptional regulator
HIN88_RS17655	COG0386	Belongs to the glutathione peroxidase family
HIN88_RS17720	COG1121	(ABC) transporter
HIN88_RS17725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIN88_RS17730	COG1280	lysine exporter protein (LysE YggA)
HIN88_RS17735	COG2837	iron assimilation
HIN88_RS17740	COG0281	malic enzyme
HIN88_RS17785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN88_RS17785	COG0519	Catalyzes the synthesis of GMP from XMP
HIN88_RS17790	COG4399	Belongs to the UPF0754 family
HIN88_RS17795	COG2259	Doxx family
HIN88_RS17800	COG0586	Pfam SNARE associated Golgi protein
HIN88_RS17815	COG1192	Involved in chromosome partitioning
HIN88_RS17825	COG0271	Belongs to the BolA IbaG family
HIN88_RS17845	COG2267	carboxylic ester hydrolase activity
HIN88_RS17865	COG3321	synthase
HIN88_RS17865	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HIN88_RS17865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIN88_RS17865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIN88_RS17870	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS17880	COG2197	response regulator
HIN88_RS17890	COG3916	Acyl-homoserine-lactone synthase
HIN88_RS17895	COG0477	Major facilitator Superfamily
HIN88_RS17900	COG1024	Enoyl-CoA hydratase
HIN88_RS17905	COG1024	Enoyl-CoA hydratase
HIN88_RS17910	COG1960	acyl-CoA dehydrogenase activity
HIN88_RS17915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_RS17935	COG1113	amino acid transport
HIN88_RS17940	COG1113	amino acid transport
HIN88_RS17945	COG0251	oxidation-reduction process
HIN88_RS17985	COG0564	pseudouridine synthase activity
HIN88_RS18060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HIN88_RS18075	COG1802	Transcriptional regulator
HIN88_RS18080	COG1448	Aminotransferase
HIN88_RS18085	COG0277	FAD linked oxidase domain protein
HIN88_RS18095	COG2186	Transcriptional regulator
HIN88_RS18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN88_RS18115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN88_RS18130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HIN88_RS18135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HIN88_RS18145	COG0438	transferase activity, transferring glycosyl groups
HIN88_RS18155	COG0438	transferase activity, transferring glycosyl groups
HIN88_RS18160	COG1215	transferase activity, transferring glycosyl groups
HIN88_RS18170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HIN88_RS18200	COG0728	peptidoglycan biosynthetic process
HIN88_RS18205	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIN88_RS18260	COG0546	phosphoglycolate phosphatase activity
HIN88_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_RS18285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_RS18290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_RS18295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_RS18300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_RS18305	COG1116	anion transmembrane transporter activity
HIN88_RS18310	COG1309	transcriptional regulator
HIN88_RS18315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIN88_RS18325	COG0196	riboflavin kinase activity
HIN88_RS18330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIN88_RS18340	COG1047	Peptidyl-prolyl cis-trans
HIN88_RS18380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIN88_RS18435	COG2951	lytic endotransglycosylase activity
HIN88_RS18440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIN88_RS18455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIN88_RS18465	COG0671	phosphoesterase, PA-phosphatase related
HIN88_RS18470	COG0861	Integral membrane protein TerC family
HIN88_RS18480	COG0754	glutathionylspermidine amidase activity
HIN88_RS18490	COG0402	S-adenosylhomocysteine deaminase activity
HIN88_RS18505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_RS18510	COG1230	cation diffusion facilitator family transporter
HIN88_RS18525	COG0706	membrane insertase activity
HIN88_RS18560	COG1373	ATPase (AAA superfamily
HIN88_RS18645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HIN88_RS18660	COG3657	addiction module killer protein
HIN88_RS18665	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_RS18690	COG3173	Aminoglycoside phosphotransferase
HIN88_RS18815	COG0551	DNA topoisomerase type I activity
HIN88_RS18815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIN88_RS18825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HIN88_RS18845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN88_RS18850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN88_RS18870	COG2369	cell adhesion
HIN88_RS18875	COG0582	viral genome integration into host DNA
HIN88_RS18915	COG1192	Involved in chromosome partitioning