locus-tag	class	description
CTZ18_RS00010	COG0592	DNA-directed DNA polymerase activity
CTZ18_RS00020	COG0187	DNA topoisomerase II activity
CTZ18_RS00030	COG0586	Pfam SNARE associated Golgi protein
CTZ18_RS00035	COG0488	(ABC) transporter
CTZ18_RS00060	COG0596	Alpha beta hydrolase
CTZ18_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CTZ18_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTZ18_RS00115	COG0733	neurotransmitter:sodium symporter activity
CTZ18_RS00155	COG2233	PERMEase
CTZ18_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS00205	COG2814	Major facilitator Superfamily
CTZ18_RS00210	COG0656	L-ascorbic acid biosynthetic process
CTZ18_RS00215	COG0583	DNA-binding transcription factor activity
CTZ18_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTZ18_RS00235	COG1064	alcohol dehydrogenase
CTZ18_RS00240	COG2818	Glycosylase
CTZ18_RS00255	COG1194	a g-specific adenine glycosylase
CTZ18_RS00275	COG2983	Belongs to the UPF0260 family
CTZ18_RS00280	COG2133	pyrroloquinoline quinone binding
CTZ18_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTZ18_RS00290	COG2116	formate transmembrane transporter activity
CTZ18_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTZ18_RS00315	COG1335	isochorismatase
CTZ18_RS00320	COG0385	Bile acid
CTZ18_RS00325	COG0534	Mate efflux family protein
CTZ18_RS00330	COG1683	Conserved Protein
CTZ18_RS00350	COG0625	glutathione transferase activity
CTZ18_RS00360	COG1113	amino acid transport
CTZ18_RS00370	COG0523	cobalamin synthesis protein
CTZ18_RS00380	COG2188	Transcriptional regulator
CTZ18_RS00410	COG0010	Belongs to the arginase family
CTZ18_RS00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTZ18_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTZ18_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CTZ18_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CTZ18_RS00555	COG0534	Mate efflux family protein
CTZ18_RS00560	COG0436	Aminotransferase
CTZ18_RS00565	COG2733	membrane
CTZ18_RS00580	COG2918	glutathione biosynthetic process
CTZ18_RS00595	COG0791	NLP P60 protein
CTZ18_RS00595	COG1388	LysM domain
CTZ18_RS00615	COG3150	esterase
CTZ18_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS00630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CTZ18_RS00640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CTZ18_RS00650	COG2233	PERMEase
CTZ18_RS00655	COG2351	hydroxyisourate hydrolase activity
CTZ18_RS00690	COG3706	GGDEF domain
CTZ18_RS00705	COG1393	Belongs to the ArsC family
CTZ18_RS00710	COG0708	Exodeoxyribonuclease III
CTZ18_RS00730	COG0189	ligase activity
CTZ18_RS00750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CTZ18_RS00760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTZ18_RS00775	COG4942	peptidase
CTZ18_RS00785	COG0508	dehydrogenase complex catalyzes the overall conversion of
CTZ18_RS00795	COG2119	membrane
CTZ18_RS00800	COG4774	siderophore transport
CTZ18_RS00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTZ18_RS00805	COG0426	domain, Protein
CTZ18_RS00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTZ18_RS00850	COG1902	pentaerythritol trinitrate reductase activity
CTZ18_RS00855	COG1519	Transferase
CTZ18_RS00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTZ18_RS00865	COG0668	transmembrane transport
CTZ18_RS00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CTZ18_RS00880	COG1335	isochorismatase
CTZ18_RS00885	COG1522	sequence-specific DNA binding
CTZ18_RS00890	COG3328	transposase activity
CTZ18_RS00915	COG0784	Response regulator, receiver
CTZ18_RS00915	COG2198	Histidine kinase
CTZ18_RS00915	COG2205	protein histidine kinase activity
CTZ18_RS00920	COG3162	membrane
CTZ18_RS00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CTZ18_RS00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CTZ18_RS00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CTZ18_RS00960	COG1309	transcriptional regulator
CTZ18_RS00980	COG0351	phosphomethylpyrimidine kinase
CTZ18_RS00980	COG0352	thiamine-phosphate diphosphorylase activity
CTZ18_RS00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CTZ18_RS00990	COG2814	Major facilitator Superfamily
CTZ18_RS01005	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CTZ18_RS01015	COG1113	amino acid transport
CTZ18_RS01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CTZ18_RS01030	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS01040	COG1335	isochorismatase
CTZ18_RS01070	COG2814	Major facilitator Superfamily
CTZ18_RS01075	COG0583	DNA-binding transcription factor activity
CTZ18_RS01095	COG0667	Aldo Keto reductase
CTZ18_RS01130	COG1733	regulation of RNA biosynthetic process
CTZ18_RS01140	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTZ18_RS01205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CTZ18_RS01220	COG2329	Antibiotic biosynthesis monooxygenase
CTZ18_RS01250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CTZ18_RS01280	COG0427	acetyl-CoA hydrolase
CTZ18_RS01305	COG0659	secondary active sulfate transmembrane transporter activity
CTZ18_RS01310	COG4221	oxidoreductase activity
CTZ18_RS01315	COG2873	o-acetylhomoserine
CTZ18_RS01320	COG0488	(ABC) transporter
CTZ18_RS01405	COG0833	amino acid
CTZ18_RS01450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTZ18_RS01455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTZ18_RS01470	COG2226	methyltransferase
CTZ18_RS01520	COG0069	glutamate synthase activity
CTZ18_RS01520	COG0067	glutamate synthase
CTZ18_RS01520	COG0070	glutamate synthase
CTZ18_RS01525	COG0493	'glutamate synthase
CTZ18_RS01535	COG1704	LemA family
CTZ18_RS01540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CTZ18_RS01550	COG4969	Belongs to the N-Me-Phe pilin family
CTZ18_RS01555	COG3307	-O-antigen
CTZ18_RS01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTZ18_RS01585	COG0194	GDP metabolic process
CTZ18_RS01635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTZ18_RS01655	COG5380	lipid catabolic process
CTZ18_RS01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTZ18_RS01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CTZ18_RS01690	COG0277	FAD linked oxidase domain protein
CTZ18_RS01700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CTZ18_RS01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTZ18_RS01720	COG1289	transmembrane transporter activity
CTZ18_RS01730	COG0628	permease
CTZ18_RS01735	COG1192	Involved in chromosome partitioning
CTZ18_RS01765	COG0833	amino acid
CTZ18_RS01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTZ18_RS01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTZ18_RS01785	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS01825	COG0583	DNA-binding transcription factor activity
CTZ18_RS01870	COG0517	IMP dehydrogenase activity
CTZ18_RS01875	COG1983	PspC domain protein
CTZ18_RS01885	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS01900	COG0408	coproporphyrinogen oxidase activity
CTZ18_RS01920	COG0513	Belongs to the DEAD box helicase family
CTZ18_RS01925	COG1127	ABC transporter
CTZ18_RS01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CTZ18_RS01940	COG2854	intermembrane phospholipid transfer
CTZ18_RS01950	COG0598	Magnesium transport protein CorA
CTZ18_RS01960	COG0494	nUDIX hydrolase
CTZ18_RS01965	COG1040	competence protein
CTZ18_RS01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTZ18_RS01990	COG1946	Acyl-CoA thioesterase
CTZ18_RS01995	COG1301	dicarboxylic acid transport
CTZ18_RS02010	COG1959	2 iron, 2 sulfur cluster binding
CTZ18_RS02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CTZ18_RS02015	COG1017	nitric oxide dioxygenase activity
CTZ18_RS02020	COG0433	COG0433 Predicted ATPase
CTZ18_RS02025	COG0626	cystathionine gamma-synthase activity
CTZ18_RS02180	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CTZ18_RS02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CTZ18_RS02220	COG0339	signal peptide processing
CTZ18_RS02225	COG0557	exoribonuclease II activity
CTZ18_RS02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
CTZ18_RS02275	COG2169	Transcriptional regulator
CTZ18_RS02280	COG0697	spore germination
CTZ18_RS02285	COG1295	ribonuclease BN
CTZ18_RS02320	COG1702	phosphate starvation-inducible protein PhoH
CTZ18_RS02330	COG0739	heme binding
CTZ18_RS02330	COG0741	lytic transglycosylase activity
CTZ18_RS02330	COG1196	nuclear chromosome segregation
CTZ18_RS02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CTZ18_RS02365	COG1183	phosphatidylcholine synthase activity
CTZ18_RS02410	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS02415	COG1309	transcriptional regulator
CTZ18_RS02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTZ18_RS02435	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS02455	COG2969	positive regulation of protein catabolic process
CTZ18_RS02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTZ18_RS02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTZ18_RS02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CTZ18_RS02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTZ18_RS02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTZ18_RS02520	COG1408	metallophosphoesterase
CTZ18_RS02530	COG2199	diguanylate cyclase activity
CTZ18_RS02590	COG1607	acyl-coa hydrolase
CTZ18_RS02620	COG2350	Protein conserved in bacteria
CTZ18_RS02630	COG0613	PHP domain protein
CTZ18_RS02635	COG3781	membrane
CTZ18_RS02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTZ18_RS02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTZ18_RS02660	COG1862	Preprotein translocase
CTZ18_RS02725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CTZ18_RS02755	COG0726	polysaccharide deacetylase
CTZ18_RS02760	COG0463	Glycosyl transferase, family 2
CTZ18_RS02765	COG0438	transferase activity, transferring glycosyl groups
CTZ18_RS02830	COG0625	glutathione transferase activity
CTZ18_RS02835	COG0583	DNA-binding transcription factor activity
CTZ18_RS02840	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS02845	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS02855	COG2205	protein histidine kinase activity
CTZ18_RS02860	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CTZ18_RS02885	COG2096	Adenosyltransferase
CTZ18_RS02935	COG0285	dihydrofolate synthase activity
CTZ18_RS02955	COG0450	alkyl hydroperoxide reductase
CTZ18_RS02970	COG0477	Major facilitator Superfamily
CTZ18_RS02975	COG1272	protein, Hemolysin III
CTZ18_RS03005	COG0183	Belongs to the thiolase family
CTZ18_RS03010	COG2207	Transcriptional regulator
CTZ18_RS03030	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTZ18_RS03050	COG0183	Belongs to the thiolase family
CTZ18_RS03060	COG2885	chlorophyll binding
CTZ18_RS03060	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CTZ18_RS03070	COG1690	Belongs to the RtcB family
CTZ18_RS03075	COG0833	amino acid
CTZ18_RS03085	COG2233	PERMEase
CTZ18_RS03090	COG1217	gtp-binding protein TYPA
CTZ18_RS03115	COG2094	Belongs to the DNA glycosylase MPG family
CTZ18_RS03120	COG4772	TonB-dependent receptor
CTZ18_RS03125	COG1902	pentaerythritol trinitrate reductase activity
CTZ18_RS03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CTZ18_RS03145	COG0354	folic acid binding
CTZ18_RS03155	COG3189	MarR family transcriptional regulator
CTZ18_RS03160	COG2824	Alkylphosphonate utilization operon protein PhnA
CTZ18_RS03165	COG3422	double-strand break repair
CTZ18_RS03205	COG0840	transmembrane signaling receptor activity
CTZ18_RS03225	COG5510	response to toxic substance
CTZ18_RS03235	COG2832	Protein of unknown function (DUF454)
CTZ18_RS03240	COG1376	ErfK ybiS ycfS ynhG family protein
CTZ18_RS03280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CTZ18_RS03290	COG1289	transmembrane transporter activity
CTZ18_RS03295	COG2814	Major facilitator Superfamily
CTZ18_RS03315	COG1115	amino acid carrier protein
CTZ18_RS03320	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTZ18_RS03325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTZ18_RS03330	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CTZ18_RS03360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTZ18_RS03370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTZ18_RS03375	COG1077	Cell shape determining protein MreB Mrl
CTZ18_RS03380	COG1792	Involved in formation and maintenance of cell shape
CTZ18_RS03385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CTZ18_RS03390	COG0424	maF-like protein
CTZ18_RS03395	COG1530	ribonuclease E activity
CTZ18_RS03405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CTZ18_RS03415	COG0560	Phosphoserine phosphatase
CTZ18_RS03425	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTZ18_RS03450	COG2207	Transcriptional regulator
CTZ18_RS03470	COG1113	amino acid transport
CTZ18_RS03475	COG2828	Protein conserved in bacteria
CTZ18_RS03480	COG0142	geranyltranstransferase activity
CTZ18_RS03485	COG2315	Protein conserved in bacteria
CTZ18_RS03500	COG1752	Esterase of the alpha-beta hydrolase superfamily
CTZ18_RS03525	COG2194	sulfuric ester hydrolase activity
CTZ18_RS03530	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS03535	COG0642	Histidine kinase
CTZ18_RS03545	COG0004	ammonium transporteR
CTZ18_RS03555	COG0583	DNA-binding transcription factor activity
CTZ18_RS03575	COG0525	valine-tRNA ligase activity
CTZ18_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS03595	COG0393	Putative heavy-metal-binding
CTZ18_RS03600	COG0393	Putative heavy-metal-binding
CTZ18_RS03605	COG1538	Outer membrane efflux protein
CTZ18_RS03615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS03620	COG0671	phosphoesterase, PA-phosphatase related
CTZ18_RS03650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CTZ18_RS03665	COG1648	precorrin-2 dehydrogenase activity
CTZ18_RS03665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CTZ18_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CTZ18_RS03675	COG1733	regulation of RNA biosynthetic process
CTZ18_RS03685	COG0531	amino acid
CTZ18_RS03700	COG0321	lipoyl(octanoyl) transferase activity
CTZ18_RS03705	COG2921	Belongs to the UPF0250 family
CTZ18_RS03745	COG2009	succinate dehydrogenase
CTZ18_RS03750	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CTZ18_RS03755	COG1053	succinate dehydrogenase
CTZ18_RS03760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CTZ18_RS03785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTZ18_RS03805	COG2354	Protein conserved in bacteria
CTZ18_RS03810	COG2321	neutral zinc metallopeptidase
CTZ18_RS03855	COG2843	Capsule synthesis protein
CTZ18_RS03870	COG0589	response to stress
CTZ18_RS03890	COG0505	Belongs to the CarA family
CTZ18_RS03915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTZ18_RS03920	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTZ18_RS03970	COG0477	Major facilitator Superfamily
CTZ18_RS03975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTZ18_RS03990	COG1597	lipid kinase activity
CTZ18_RS03995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CTZ18_RS04020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTZ18_RS04025	COG0584	glycerophosphoryl diester phosphodiesterase
CTZ18_RS04045	COG0741	lytic transglycosylase activity
CTZ18_RS04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTZ18_RS04085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CTZ18_RS04115	COG0778	Nitroreductase
CTZ18_RS04130	COG1929	Belongs to the glycerate kinase type-1 family
CTZ18_RS04135	COG0243	molybdopterin cofactor binding
CTZ18_RS04140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CTZ18_RS04145	COG3339	Conserved Protein
CTZ18_RS04155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CTZ18_RS04170	COG1113	amino acid transport
CTZ18_RS04180	COG0019	diaminopimelate decarboxylase activity
CTZ18_RS04190	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS04195	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CTZ18_RS04225	COG0463	Glycosyl transferase, family 2
CTZ18_RS04245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS04275	COG4591	ABC-type transport system involved in lipoprotein release permease component
CTZ18_RS04280	COG1136	(ABC) transporter
CTZ18_RS04285	COG2333	competence protein COMEC
CTZ18_RS04285	COG0658	competence protein
CTZ18_RS04295	COG0616	signal peptide processing
CTZ18_RS04295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CTZ18_RS04300	COG0596	Alpha beta hydrolase
CTZ18_RS04305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTZ18_RS04315	COG0628	permease
CTZ18_RS04350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTZ18_RS04370	COG0823	Involved in the tonB-independent uptake of proteins
CTZ18_RS04390	COG0824	Thioesterase
CTZ18_RS04395	COG1473	amidohydrolase
CTZ18_RS04415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTZ18_RS04415	COG0047	phosphoribosylformylglycinamidine synthase activity
CTZ18_RS04420	COG2814	Major facilitator Superfamily
CTZ18_RS04430	COG1024	Enoyl-CoA hydratase
CTZ18_RS04435	COG1056	cytidyltransferase-related domain
CTZ18_RS04435	COG1051	belongs to the nudix hydrolase family
CTZ18_RS04445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CTZ18_RS04460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CTZ18_RS04475	COG4625	pathogenesis
CTZ18_RS04480	COG0583	DNA-binding transcription factor activity
CTZ18_RS04485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CTZ18_RS04490	COG4208	sulfate ABC transporter
CTZ18_RS04495	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CTZ18_RS04505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CTZ18_RS04510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTZ18_RS04515	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CTZ18_RS04535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTZ18_RS04550	COG0681	Belongs to the peptidase S26 family
CTZ18_RS04565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTZ18_RS04575	COG1381	Involved in DNA repair and RecF pathway recombination
CTZ18_RS04580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CTZ18_RS04590	COG4221	oxidoreductase activity
CTZ18_RS04620	COG0436	Aminotransferase
CTZ18_RS04640	COG0556	nucleotide-excision repair
CTZ18_RS04695	COG2070	2-Nitropropane dioxygenase
CTZ18_RS04725	COG1215	transferase activity, transferring glycosyl groups
CTZ18_RS04740	COG0415	Belongs to the DNA photolyase family
CTZ18_RS04750	COG1252	NADH dehydrogenase
CTZ18_RS04755	COG1686	Belongs to the peptidase S11 family
CTZ18_RS04770	COG1187	pseudouridine synthase activity
CTZ18_RS04795	COG0477	Major facilitator Superfamily
CTZ18_RS04800	COG0583	DNA-binding transcription factor activity
CTZ18_RS04805	COG1823	symporter activity
CTZ18_RS04815	COG0612	Peptidase, M16
CTZ18_RS04840	COG0352	thiamine-phosphate diphosphorylase activity
CTZ18_RS04875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CTZ18_RS04890	COG1309	transcriptional regulator
CTZ18_RS04900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CTZ18_RS04905	COG0076	glutamate decarboxylase activity
CTZ18_RS04915	COG1522	sequence-specific DNA binding
CTZ18_RS04920	COG3961	Belongs to the TPP enzyme family
CTZ18_RS04925	COG1113	amino acid transport
CTZ18_RS04930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CTZ18_RS04935	COG0573	inorganic phosphate transmembrane transporter activity
CTZ18_RS04945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTZ18_RS04950	COG0616	signal peptide processing
CTZ18_RS04985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CTZ18_RS04990	COG1686	Belongs to the peptidase S11 family
CTZ18_RS05015	COG0583	DNA-binding transcription factor activity
CTZ18_RS05020	COG1067	ATP-dependent peptidase activity
CTZ18_RS05065	COG1966	Carbon starvation protein
CTZ18_RS05070	COG2879	small protein
CTZ18_RS05105	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CTZ18_RS05105	COG2508	Transcriptional regulator
CTZ18_RS05125	COG1113	amino acid transport
CTZ18_RS05130	COG0583	DNA-binding transcription factor activity
CTZ18_RS05135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CTZ18_RS05140	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CTZ18_RS05150	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS05155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTZ18_RS05160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CTZ18_RS05160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CTZ18_RS05195	COG2814	Major facilitator Superfamily
CTZ18_RS05200	COG4948	Mandelate Racemase Muconate Lactonizing
CTZ18_RS05210	COG1309	transcriptional regulator
CTZ18_RS05230	COG1741	Belongs to the pirin family
CTZ18_RS05240	COG2964	Protein conserved in bacteria
CTZ18_RS05255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CTZ18_RS05260	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTZ18_RS05265	COG4605	iron ion homeostasis
CTZ18_RS05270	COG4604	ABC transporter, ATP-binding protein
CTZ18_RS05275	COG4607	ABC-type enterochelin transport system periplasmic component
CTZ18_RS05280	COG4774	siderophore transport
CTZ18_RS05290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CTZ18_RS05295	COG1021	2,3-dihydroxybenzoate-AMP ligase
CTZ18_RS05300	COG3433	isochorismatase activity
CTZ18_RS05300	COG1535	isochorismatase
CTZ18_RS05315	COG1132	(ABC) transporter
CTZ18_RS05320	COG1132	(ABC) transporter
CTZ18_RS05325	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
CTZ18_RS05335	COG1169	isochorismate synthase
CTZ18_RS05350	COG3739	integral membrane protein
CTZ18_RS05370	COG0302	gtp cyclohydrolase
CTZ18_RS05380	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CTZ18_RS05410	COG0308	aminopeptidase N
CTZ18_RS05415	COG0512	Glutamine amidotransferase of anthranilate synthase
CTZ18_RS05430	COG0174	glutamine synthetase
CTZ18_RS05440	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CTZ18_RS05475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CTZ18_RS05480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CTZ18_RS05485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTZ18_RS05505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CTZ18_RS05510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTZ18_RS05515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CTZ18_RS05530	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS05535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CTZ18_RS05540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTZ18_RS05550	COG2223	nitrite transmembrane transporter activity
CTZ18_RS05560	COG0024	Methionine aminopeptidase
CTZ18_RS05565	COG0052	Belongs to the universal ribosomal protein uS2 family
CTZ18_RS05580	COG2207	Transcriptional regulator
CTZ18_RS05605	COG2951	lytic endotransglycosylase activity
CTZ18_RS05610	COG0772	Belongs to the SEDS family
CTZ18_RS05625	COG0842	Transport permease protein
CTZ18_RS05630	COG1131	(ABC) transporter
CTZ18_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS05700	COG4215	(ABC) transporter
CTZ18_RS05705	COG4160	amino acid transport
CTZ18_RS05710	COG4598	ABC transporter
CTZ18_RS05720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTZ18_RS05725	COG0826	peptidase U32
CTZ18_RS05730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTZ18_RS05745	COG1720	tRNA m6t6A37 methyltransferase activity
CTZ18_RS05755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTZ18_RS05770	COG0642	Histidine kinase
CTZ18_RS05780	COG0494	nUDIX hydrolase
CTZ18_RS05790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CTZ18_RS05795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTZ18_RS05800	COG3139	Protein of unknown function (DUF1315)
CTZ18_RS05805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTZ18_RS05815	COG1301	dicarboxylic acid transport
CTZ18_RS05820	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS05825	COG2819	hydrolase of the alpha beta superfamily
CTZ18_RS05835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTZ18_RS05845	COG2195	Cleaves the N-terminal amino acid of tripeptides
CTZ18_RS05850	COG1234	tRNA 3'-trailer cleavage
CTZ18_RS05880	COG2363	Small membrane protein
CTZ18_RS05900	COG0513	Belongs to the DEAD box helicase family
CTZ18_RS05910	COG0778	Nitroreductase
CTZ18_RS06225	COG0739	heme binding
CTZ18_RS06295	COG1286	toxin biosynthetic process
CTZ18_RS06320	COG4783	chaperone-mediated protein folding
CTZ18_RS06325	COG1610	YqeY-like protein
CTZ18_RS06425	COG3111	PFAM Bacterial OB fold (BOF) protein
CTZ18_RS06450	COG3243	poly(R)-hydroxyalkanoic acid synthase
CTZ18_RS06455	COG0786	glutamate:sodium symporter activity
CTZ18_RS06465	COG2186	Transcriptional regulator
CTZ18_RS06515	COG0477	Major facilitator Superfamily
CTZ18_RS06545	COG2985	domain, Protein
CTZ18_RS06555	COG2995	paraquat-inducible protein a
CTZ18_RS06560	COG3008	intermembrane lipid transfer
CTZ18_RS06560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CTZ18_RS06570	COG1794	racemase activity, acting on amino acids and derivatives
CTZ18_RS06600	COG1301	dicarboxylic acid transport
CTZ18_RS06610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTZ18_RS06615	COG2011	ABC-type metal ion transport system permease component
CTZ18_RS06620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CTZ18_RS06625	COG1464	Belongs to the NlpA lipoprotein family
CTZ18_RS06630	COG0151	Belongs to the GarS family
CTZ18_RS06635	COG0138	bifunctional purine biosynthesis protein purh
CTZ18_RS06640	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CTZ18_RS06670	COG2308	Evidence 4 Homologs of previously reported genes of
CTZ18_RS06680	COG1305	Transglutaminase-like
CTZ18_RS06690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CTZ18_RS06695	COG0305	Participates in initiation and elongation during chromosome replication
CTZ18_RS06720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CTZ18_RS06730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CTZ18_RS06735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CTZ18_RS06760	COG0726	polysaccharide deacetylase
CTZ18_RS06760	COG1649	PFAM Uncharacterised BCR, COG1649
CTZ18_RS06765	COG1215	transferase activity, transferring glycosyl groups
CTZ18_RS06770	COG3658	cytochrome
CTZ18_RS06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CTZ18_RS06800	COG0583	DNA-binding transcription factor activity
CTZ18_RS06820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTZ18_RS06825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTZ18_RS06840	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CTZ18_RS06850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTZ18_RS06875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CTZ18_RS06880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CTZ18_RS06890	COG2205	protein histidine kinase activity
CTZ18_RS06895	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS06900	COG0174	glutamine synthetase
CTZ18_RS06920	COG0729	surface antigen
CTZ18_RS06950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CTZ18_RS06955	COG2814	Major facilitator Superfamily
CTZ18_RS06970	COG0583	DNA-binding transcription factor activity
CTZ18_RS06985	COG1187	pseudouridine synthase activity
CTZ18_RS07005	COG0802	atpase or kinase
CTZ18_RS07010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTZ18_RS07020	COG1923	regulation of RNA biosynthetic process
CTZ18_RS07025	COG0697	spore germination
CTZ18_RS07040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTZ18_RS07050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTZ18_RS07055	COG0519	Catalyzes the synthesis of GMP from XMP
CTZ18_RS07055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTZ18_RS07060	COG4302	ethanolamine ammonia-lyase activity
CTZ18_RS07065	COG4303	Ethanolamine ammonia lyase large subunit
CTZ18_RS07070	COG0531	amino acid
CTZ18_RS07090	COG1454	alcohol dehydrogenase
CTZ18_RS07095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTZ18_RS07105	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CTZ18_RS07125	COG0308	aminopeptidase N
CTZ18_RS07135	COG4221	oxidoreductase activity
CTZ18_RS07145	COG1605	Chorismate mutase
CTZ18_RS07165	COG1309	transcriptional regulator
CTZ18_RS07175	COG0668	transmembrane transport
CTZ18_RS07205	COG4773	Receptor
CTZ18_RS07225	COG0488	(ABC) transporter
CTZ18_RS07230	COG0589	response to stress
CTZ18_RS07250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CTZ18_RS07260	COG3135	benzoate transporter
CTZ18_RS07265	COG1522	sequence-specific DNA binding
CTZ18_RS07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTZ18_RS07280	COG0583	DNA-binding transcription factor activity
CTZ18_RS07290	COG0183	Belongs to the thiolase family
CTZ18_RS07300	COG2030	dehydratase
CTZ18_RS07305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CTZ18_RS07320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTZ18_RS07330	COG0824	Thioesterase
CTZ18_RS07335	COG1454	alcohol dehydrogenase
CTZ18_RS07345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CTZ18_RS07365	COG0069	glutamate synthase activity
CTZ18_RS07650	COG1598	PFAM Uncharacterised protein family UPF0150
CTZ18_RS07740	COG2814	Major facilitator Superfamily
CTZ18_RS07755	COG0511	ligase activity, forming carbon-carbon bonds
CTZ18_RS07775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTZ18_RS07775	COG1116	anion transmembrane transporter activity
CTZ18_RS07780	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS07790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTZ18_RS07790	COG2146	nitrite reductase [NAD(P)H] activity
CTZ18_RS07795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTZ18_RS07800	COG0243	molybdopterin cofactor binding
CTZ18_RS07810	COG0243	molybdopterin cofactor binding
CTZ18_RS07815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTZ18_RS07830	COG0521	Mo-molybdopterin cofactor biosynthetic process
CTZ18_RS07830	COG0315	cyclic pyranopterin monophosphate synthase activity
CTZ18_RS07835	COG0303	'Molybdopterin
CTZ18_RS07845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTZ18_RS07850	COG0697	spore germination
CTZ18_RS07870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CTZ18_RS07875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTZ18_RS07935	COG2204	response regulator
CTZ18_RS07940	COG3852	Histidine kinase
CTZ18_RS07960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTZ18_RS07965	COG0575	Belongs to the CDS family
CTZ18_RS08000	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTZ18_RS08015	COG2137	regulation of response to DNA damage stimulus
CTZ18_RS08025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CTZ18_RS08030	COG1011	Hydrolase
CTZ18_RS08055	COG1522	sequence-specific DNA binding
CTZ18_RS08065	COG1113	amino acid transport
CTZ18_RS08085	COG0659	secondary active sulfate transmembrane transporter activity
CTZ18_RS08130	COG1132	(ABC) transporter
CTZ18_RS08185	COG0482	sulfurtransferase activity
CTZ18_RS08200	COG0488	(ABC) transporter
CTZ18_RS08205	COG3173	Aminoglycoside phosphotransferase
CTZ18_RS08215	COG2433	Pfam Transposase IS66
CTZ18_RS08275	COG0024	Methionine aminopeptidase
CTZ18_RS08280	COG0583	DNA-binding transcription factor activity
CTZ18_RS08290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CTZ18_RS08295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTZ18_RS08300	COG0516	GMP reductase activity
CTZ18_RS08300	COG0517	IMP dehydrogenase activity
CTZ18_RS08325	COG0552	protein localization to endoplasmic reticulum
CTZ18_RS08335	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CTZ18_RS08350	COG4890	Cyd operon protein YbgT
CTZ18_RS08355	COG1294	oxidase, subunit
CTZ18_RS08370	COG1585	Membrane protein implicated in regulation of membrane protease activity
CTZ18_RS08380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTZ18_RS08385	COG4774	siderophore transport
CTZ18_RS08400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CTZ18_RS08405	COG0569	domain protein
CTZ18_RS08410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTZ18_RS08440	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CTZ18_RS08445	COG0542	response to heat
CTZ18_RS08470	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTZ18_RS08470	COG1902	pentaerythritol trinitrate reductase activity
CTZ18_RS08515	COG2323	membrane
CTZ18_RS08520	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CTZ18_RS08530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTZ18_RS08535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTZ18_RS08540	COG0183	Belongs to the thiolase family
CTZ18_RS08545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTZ18_RS08550	COG0596	Alpha beta hydrolase
CTZ18_RS08555	COG2271	Major facilitator Superfamily
CTZ18_RS08560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CTZ18_RS08565	COG3485	protocatechuate 3,4-dioxygenase
CTZ18_RS08570	COG3485	protocatechuate 3,4-dioxygenase
CTZ18_RS08575	COG0710	3-dehydroquinate dehydratase activity
CTZ18_RS08580	COG3420	alginic acid biosynthetic process
CTZ18_RS08585	COG3659	wide pore channel activity
CTZ18_RS08590	COG4993	Dehydrogenase
CTZ18_RS08600	COG2391	methyltransferase activity
CTZ18_RS08615	COG1414	Transcriptional regulator
CTZ18_RS08620	COG0583	DNA-binding transcription factor activity
CTZ18_RS08625	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS08650	COG2814	Major facilitator Superfamily
CTZ18_RS08660	COG0154	amidase activity
CTZ18_RS08680	COG4638	Rieske (2fe-2S)
CTZ18_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS08700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTZ18_RS08710	COG3733	amine oxidase
CTZ18_RS08720	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS08730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CTZ18_RS08735	COG0183	Belongs to the thiolase family
CTZ18_RS08740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTZ18_RS08745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTZ18_RS08755	COG4829	muconolactone delta-isomerase
CTZ18_RS08760	COG4948	Mandelate Racemase Muconate Lactonizing
CTZ18_RS08765	COG0583	DNA-binding transcription factor activity
CTZ18_RS08775	COG2186	Transcriptional regulator
CTZ18_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS08815	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS08825	COG3829	transcription factor binding
CTZ18_RS08835	COG3162	membrane
CTZ18_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS08865	COG0753	catalase activity
CTZ18_RS08890	COG1846	Transcriptional regulator
CTZ18_RS08895	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTZ18_RS08895	COG1902	pentaerythritol trinitrate reductase activity
CTZ18_RS08905	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTZ18_RS08935	COG1309	transcriptional regulator
CTZ18_RS08945	COG1335	isochorismatase
CTZ18_RS08950	COG0583	DNA-binding transcription factor activity
CTZ18_RS08960	COG0475	glutathione-regulated potassium exporter activity
CTZ18_RS08960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CTZ18_RS08970	COG1473	amidohydrolase
CTZ18_RS08985	COG2831	hemolysin activation secretion protein
CTZ18_RS08990	COG3210	domain, Protein
CTZ18_RS09020	COG2188	Transcriptional regulator
CTZ18_RS09035	COG0583	DNA-binding transcription factor activity
CTZ18_RS09065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CTZ18_RS09085	COG1566	PFAM secretion protein HlyD family protein
CTZ18_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS09105	COG0129	dihydroxy-acid dehydratase activity
CTZ18_RS09115	COG0583	DNA-binding transcription factor activity
CTZ18_RS09120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CTZ18_RS09130	COG2084	Dehydrogenase
CTZ18_RS09135	COG2207	Transcriptional regulator
CTZ18_RS09150	COG1064	alcohol dehydrogenase
CTZ18_RS09160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTZ18_RS09165	COG1120	ATPase activity
CTZ18_RS09185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTZ18_RS09305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CTZ18_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS09375	COG2207	Transcriptional regulator
CTZ18_RS09385	COG2205	protein histidine kinase activity
CTZ18_RS09390	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS09395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS09400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CTZ18_RS09405	COG1538	Outer membrane efflux protein
CTZ18_RS09415	COG2072	flavoprotein involved in K transport
CTZ18_RS09435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CTZ18_RS09455	COG3539	Fimbrial protein
CTZ18_RS09485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CTZ18_RS09495	COG0753	catalase activity
CTZ18_RS09510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CTZ18_RS09575	COG1535	isochorismatase
CTZ18_RS09575	COG3433	isochorismatase activity
CTZ18_RS09580	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS09585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CTZ18_RS09590	COG4149	molybdate abc transporter
CTZ18_RS09595	COG0725	ABC transporter, periplasmic molybdate-binding protein
CTZ18_RS09605	COG4638	Rieske (2fe-2S)
CTZ18_RS09610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CTZ18_RS09615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CTZ18_RS09615	COG0543	2 iron, 2 sulfur cluster binding
CTZ18_RS09640	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS09655	COG2207	Transcriptional regulator
CTZ18_RS09665	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS09670	COG2610	gluconate transmembrane transporter activity
CTZ18_RS09680	COG0583	DNA-binding transcription factor activity
CTZ18_RS09690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTZ18_RS09695	COG2031	fatty acid transporter
CTZ18_RS09700	COG0183	Belongs to the thiolase family
CTZ18_RS09705	COG0583	DNA-binding transcription factor activity
CTZ18_RS09710	COG0583	DNA-binding transcription factor activity
CTZ18_RS09725	COG1027	Aspartate ammonia-lyase
CTZ18_RS09735	COG0477	Major facilitator Superfamily
CTZ18_RS09755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTZ18_RS09760	COG4521	taurine ABC transporter
CTZ18_RS09775	COG2188	Transcriptional regulator
CTZ18_RS09785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CTZ18_RS09790	COG1733	regulation of RNA biosynthetic process
CTZ18_RS09795	COG3708	Transcriptional regulator
CTZ18_RS09795	COG2207	Transcriptional regulator
CTZ18_RS09810	COG0730	response to heat
CTZ18_RS09820	COG3453	Protein conserved in bacteria
CTZ18_RS09820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTZ18_RS09830	COG3781	membrane
CTZ18_RS09835	COG1063	alcohol dehydrogenase
CTZ18_RS09845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CTZ18_RS09850	COG0508	dehydrogenase complex catalyzes the overall conversion of
CTZ18_RS09855	COG0022	dehydrogenase e1 component
CTZ18_RS09860	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CTZ18_RS09865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CTZ18_RS09880	COG3706	GGDEF domain
CTZ18_RS09895	COG0133	tryptophan synthase activity
CTZ18_RS09905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTZ18_RS09940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CTZ18_RS09965	COG2226	methyltransferase
CTZ18_RS10020	COG0842	Transport permease protein
CTZ18_RS10025	COG0842	Transport permease protein
CTZ18_RS10030	COG1131	(ABC) transporter
CTZ18_RS10045	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CTZ18_RS10050	COG4773	Receptor
CTZ18_RS10070	COG0730	response to heat
CTZ18_RS10075	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CTZ18_RS10095	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CTZ18_RS10155	COG4264	IucA IucC family
CTZ18_RS10160	COG4264	IucA IucC family
CTZ18_RS10180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CTZ18_RS10195	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS10200	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS10205	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CTZ18_RS10210	COG2207	Transcriptional regulator
CTZ18_RS10215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTZ18_RS10220	COG0776	regulation of translation
CTZ18_RS10245	COG0822	iron-sulfur transferase activity
CTZ18_RS10250	COG0316	Belongs to the HesB IscA family
CTZ18_RS10280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTZ18_RS10300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CTZ18_RS10305	COG0702	epimerase
CTZ18_RS10340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTZ18_RS10350	COG0339	signal peptide processing
CTZ18_RS10395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CTZ18_RS10400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CTZ18_RS10430	COG0776	regulation of translation
CTZ18_RS10495	COG0084	hydrolase, TatD family'
CTZ18_RS10515	COG1663	tetraacyldisaccharide 4'-kinase activity
CTZ18_RS10520	COG1132	(ABC) transporter
CTZ18_RS10530	COG0811	peptide transport
CTZ18_RS10535	COG1475	DNA binding
CTZ18_RS10540	COG1192	Involved in chromosome partitioning
CTZ18_RS10550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CTZ18_RS10565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CTZ18_RS10570	COG0191	fructose-bisphosphate aldolase activity
CTZ18_RS10590	COG0424	maF-like protein
CTZ18_RS10595	COG2850	peptidyl-arginine hydroxylation
CTZ18_RS10605	COG0640	Transcriptional regulator
CTZ18_RS10615	COG3619	membrane
CTZ18_RS10620	COG3122	Protein conserved in bacteria
CTZ18_RS10625	COG1132	(ABC) transporter
CTZ18_RS10645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTZ18_RS10650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CTZ18_RS10660	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CTZ18_RS10660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CTZ18_RS10660	COG0506	proline dehydrogenase activity
CTZ18_RS10665	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CTZ18_RS10680	COG3698	Phosphodiester glycosidase
CTZ18_RS10690	COG2353	YceI-like domain
CTZ18_RS10700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CTZ18_RS10745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTZ18_RS10745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTZ18_RS10770	COG3539	Fimbrial protein
CTZ18_RS10775	COG3121	Chaperone
CTZ18_RS10805	COG0697	spore germination
CTZ18_RS10815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CTZ18_RS10825	COG0583	DNA-binding transcription factor activity
CTZ18_RS10845	COG1309	transcriptional regulator
CTZ18_RS10860	COG1522	sequence-specific DNA binding
CTZ18_RS10870	COG1126	abc transporter atp-binding protein
CTZ18_RS10875	COG0765	amino acid transport
CTZ18_RS10880	COG0765	amino acid transport
CTZ18_RS10910	COG1464	Belongs to the NlpA lipoprotein family
CTZ18_RS10935	COG2011	ABC-type metal ion transport system permease component
CTZ18_RS10940	COG0012	GTP binding
CTZ18_RS10965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CTZ18_RS11005	COG0386	Belongs to the glutathione peroxidase family
CTZ18_RS11015	COG0436	Aminotransferase
CTZ18_RS11055	COG3634	alkyl hydroperoxide reductase activity
CTZ18_RS11070	COG0583	DNA-binding transcription factor activity
CTZ18_RS11075	COG0798	PFAM Bile acid sodium symporter
CTZ18_RS11080	COG0640	Transcriptional regulator
CTZ18_RS11095	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CTZ18_RS11105	COG0583	DNA-binding transcription factor activity
CTZ18_RS11115	COG1953	Uracil, thiamine, allantoin
CTZ18_RS11125	COG2175	clavaminate synthase activity
CTZ18_RS11130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTZ18_RS11135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CTZ18_RS11140	COG4521	taurine ABC transporter
CTZ18_RS11150	COG0477	Major facilitator Superfamily
CTZ18_RS11175	COG1271	oxidase subunit
CTZ18_RS11180	COG1294	oxidase, subunit
CTZ18_RS11190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTZ18_RS11210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTZ18_RS11230	COG3052	prosthetic group binding
CTZ18_RS11235	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CTZ18_RS11245	COG2814	Major facilitator Superfamily
CTZ18_RS11265	COG1346	cytolysis
CTZ18_RS11275	COG0583	DNA-binding transcription factor activity
CTZ18_RS11280	COG0625	glutathione transferase activity
CTZ18_RS11285	COG0625	glutathione transferase activity
CTZ18_RS11290	COG0583	DNA-binding transcription factor activity
CTZ18_RS11305	COG1045	serine acetyltransferase
CTZ18_RS11310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CTZ18_RS11315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTZ18_RS11325	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS11340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTZ18_RS11345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTZ18_RS11350	COG1126	abc transporter atp-binding protein
CTZ18_RS11355	COG0765	amino acid transport
CTZ18_RS11360	COG0765	amino acid transport
CTZ18_RS11380	COG0784	Response regulator, receiver
CTZ18_RS11380	COG2205	protein histidine kinase activity
CTZ18_RS11400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTZ18_RS11420	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS11465	COG0583	DNA-binding transcription factor activity
CTZ18_RS11485	COG0318	PFAM AMP-dependent synthetase and ligase
CTZ18_RS11490	COG1309	transcriptional regulator
CTZ18_RS11495	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS11500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTZ18_RS11505	COG1024	Enoyl-CoA hydratase
CTZ18_RS11510	COG4770	biotin carboxylase activity
CTZ18_RS11520	COG0583	DNA-binding transcription factor activity
CTZ18_RS11535	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS11545	COG2814	Major facilitator Superfamily
CTZ18_RS11555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CTZ18_RS11560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CTZ18_RS11565	COG2814	Major facilitator Superfamily
CTZ18_RS11570	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS11575	COG1024	Enoyl-CoA hydratase
CTZ18_RS11580	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS11585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTZ18_RS11590	COG0183	Belongs to the thiolase family
CTZ18_RS11600	COG2814	Major facilitator Superfamily
CTZ18_RS11610	COG1024	Enoyl-CoA hydratase
CTZ18_RS11625	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS11630	COG2814	Major facilitator Superfamily
CTZ18_RS11635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTZ18_RS11640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTZ18_RS11655	COG3842	ATPase activity
CTZ18_RS11660	COG1840	ABC-type Fe3 transport system, periplasmic component
CTZ18_RS11670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CTZ18_RS11675	COG1414	Transcriptional regulator
CTZ18_RS11685	COG0583	DNA-binding transcription factor activity
CTZ18_RS11690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CTZ18_RS11695	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS11705	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CTZ18_RS11715	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS11720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CTZ18_RS11725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTZ18_RS11730	COG2267	carboxylic ester hydrolase activity
CTZ18_RS11750	COG3038	cytochrome b561
CTZ18_RS11755	COG0753	catalase activity
CTZ18_RS11795	COG2050	protein possibly involved in aromatic compounds catabolism
CTZ18_RS11805	COG3327	negative regulation of DNA-templated transcription, initiation
CTZ18_RS11810	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CTZ18_RS11815	COG0183	Belongs to the thiolase family
CTZ18_RS11820	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTZ18_RS11825	COG1024	Enoyl-CoA hydratase
CTZ18_RS11830	COG1024	Enoyl-CoA hydratase
CTZ18_RS11835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CTZ18_RS11840	COG2151	metal-sulfur cluster biosynthetic enzyme
CTZ18_RS11845	COG3396	Phenylacetate-CoA oxygenase
CTZ18_RS11850	COG3460	Phenylacetate-CoA oxygenase
CTZ18_RS11855	COG3396	Phenylacetate-CoA oxygenase
CTZ18_RS11860	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS11860	COG2030	dehydratase
CTZ18_RS11865	COG1760	l-serine dehydratase
CTZ18_RS11870	COG0531	amino acid
CTZ18_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS11890	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTZ18_RS11900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CTZ18_RS11920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTZ18_RS11935	COG0789	Transcriptional regulator
CTZ18_RS11950	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTZ18_RS11965	COG2807	transmembrane transport
CTZ18_RS11970	COG0590	tRNA wobble adenosine to inosine editing
CTZ18_RS12090	COG1116	anion transmembrane transporter activity
CTZ18_RS12095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTZ18_RS12105	COG0864	Transcriptional regulator
CTZ18_RS12125	COG2249	NAD(P)H dehydrogenase (quinone) activity
CTZ18_RS12130	COG0439	Biotin carboxylase
CTZ18_RS12145	COG1063	alcohol dehydrogenase
CTZ18_RS12155	COG1309	transcriptional regulator
CTZ18_RS12180	COG0038	chloride channel
CTZ18_RS12185	COG4770	biotin carboxylase activity
CTZ18_RS12205	COG1914	H( )-stimulated, divalent metal cation uptake system
CTZ18_RS12210	COG0583	DNA-binding transcription factor activity
CTZ18_RS12265	COG1250	3-hydroxyacyl-CoA dehydrogenase
CTZ18_RS12285	COG2814	Major facilitator Superfamily
CTZ18_RS12295	COG1560	Kdo2-lipid A biosynthetic process
CTZ18_RS12305	COG5006	permease, DMT superfamily
CTZ18_RS12310	COG1522	sequence-specific DNA binding
CTZ18_RS12325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CTZ18_RS12335	COG4122	O-methyltransferase activity
CTZ18_RS12365	COG1538	Outer membrane efflux protein
CTZ18_RS12370	COG1137	ATPase activity
CTZ18_RS12375	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CTZ18_RS12385	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CTZ18_RS12390	COG0517	IMP dehydrogenase activity
CTZ18_RS12390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CTZ18_RS12430	COG2814	Major facilitator Superfamily
CTZ18_RS12470	COG1278	Cold shock
CTZ18_RS12475	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS12510	COG1570	exodeoxyribonuclease VII activity
CTZ18_RS12565	COG0583	DNA-binding transcription factor activity
CTZ18_RS12570	COG4638	Rieske (2fe-2S)
CTZ18_RS12575	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CTZ18_RS12580	COG0543	2 iron, 2 sulfur cluster binding
CTZ18_RS12580	COG0633	Ferredoxin
CTZ18_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS12590	COG3135	benzoate transporter
CTZ18_RS12595	COG2814	Major facilitator Superfamily
CTZ18_RS12610	COG1643	Atp-dependent helicase
CTZ18_RS12615	COG0450	alkyl hydroperoxide reductase
CTZ18_RS12625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CTZ18_RS12635	COG3634	alkyl hydroperoxide reductase activity
CTZ18_RS12655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTZ18_RS12660	COG0625	glutathione transferase activity
CTZ18_RS12670	COG2885	chlorophyll binding
CTZ18_RS12705	COG0542	response to heat
CTZ18_RS12720	COG1765	OsmC-like protein
CTZ18_RS12730	COG0667	Aldo Keto reductase
CTZ18_RS12745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTZ18_RS12755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CTZ18_RS12765	COG0527	aspartate kinase activity
CTZ18_RS12775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTZ18_RS12785	COG3038	cytochrome b561
CTZ18_RS12790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CTZ18_RS12795	COG2252	PERMEase
CTZ18_RS12805	COG2072	flavoprotein involved in K transport
CTZ18_RS12830	COG1309	transcriptional regulator
CTZ18_RS12840	COG0300	oxidoreductase activity
CTZ18_RS12970	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CTZ18_RS13010	COG1113	amino acid transport
CTZ18_RS13030	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS13050	COG0531	amino acid
CTZ18_RS13060	COG1113	amino acid transport
CTZ18_RS13105	COG3209	COG3209 Rhs family protein
CTZ18_RS13130	COG4269	membrane
CTZ18_RS13145	COG1902	pentaerythritol trinitrate reductase activity
CTZ18_RS13145	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTZ18_RS13155	COG5001	Diguanylate cyclase
CTZ18_RS13155	COG4251	negative regulation of phosphorylation
CTZ18_RS13155	COG3706	GGDEF domain
CTZ18_RS13155	COG2203	Gaf domain
CTZ18_RS13165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CTZ18_RS13185	COG4172	Belongs to the ABC transporter superfamily
CTZ18_RS13190	COG4239	(ABC) transporter, permease
CTZ18_RS13195	COG4174	ABC transporter (Permease)
CTZ18_RS13205	COG0741	lytic transglycosylase activity
CTZ18_RS13205	COG1388	LysM domain
CTZ18_RS13205	COG0741	lytic transglycosylase activity
CTZ18_RS13205	COG1388	LysM domain
CTZ18_RS13210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CTZ18_RS13250	COG0583	DNA-binding transcription factor activity
CTZ18_RS13255	COG1279	arginine transmembrane transporter activity
CTZ18_RS13275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CTZ18_RS13280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CTZ18_RS13285	COG0006	proline dipeptidase activity
CTZ18_RS13320	COG2194	sulfuric ester hydrolase activity
CTZ18_RS13365	COG0739	heme binding
CTZ18_RS13690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CTZ18_RS13715	COG3384	dioxygenase
CTZ18_RS13725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTZ18_RS13730	COG2878	Part of a membrane complex involved in electron transport
CTZ18_RS13735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTZ18_RS13760	COG0768	penicillin binding
CTZ18_RS13765	COG0742	ribosomal rna small subunit methyltransferase
CTZ18_RS13780	COG0830	nickel cation binding
CTZ18_RS13830	COG1253	flavin adenine dinucleotide binding
CTZ18_RS13840	COG2851	Citrate transporter
CTZ18_RS13890	COG1773	rubredoxin
CTZ18_RS13895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTZ18_RS13905	COG0583	DNA-binding transcription factor activity
CTZ18_RS13935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CTZ18_RS13940	COG4181	ATPase activity
CTZ18_RS13985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CTZ18_RS14005	COG0306	phosphate transporter
CTZ18_RS14015	COG3958	Transketolase
CTZ18_RS14020	COG3959	Transketolase, thiamine diphosphate binding domain
CTZ18_RS14025	COG2271	Major facilitator Superfamily
CTZ18_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS14035	COG0583	DNA-binding transcription factor activity
CTZ18_RS14055	COG2223	nitrite transmembrane transporter activity
CTZ18_RS14060	COG2207	Transcriptional regulator
CTZ18_RS14065	COG2066	Belongs to the glutaminase family
CTZ18_RS14070	COG0242	peptide deformylase activity
CTZ18_RS14075	COG0477	Major facilitator Superfamily
CTZ18_RS14085	COG0028	Belongs to the TPP enzyme family
CTZ18_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS14105	COG2267	carboxylic ester hydrolase activity
CTZ18_RS14115	COG2271	Major facilitator Superfamily
CTZ18_RS14120	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTZ18_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS14150	COG1414	Transcriptional regulator
CTZ18_RS14165	COG1024	Enoyl-CoA hydratase
CTZ18_RS14175	COG1215	transferase activity, transferring glycosyl groups
CTZ18_RS14180	COG1649	PFAM Uncharacterised BCR, COG1649
CTZ18_RS14180	COG0726	polysaccharide deacetylase
CTZ18_RS14190	COG4681	YaeQ
CTZ18_RS14200	COG0523	cobalamin synthesis protein
CTZ18_RS14210	COG1607	acyl-coa hydrolase
CTZ18_RS14220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CTZ18_RS14225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CTZ18_RS14230	COG1309	transcriptional regulator
CTZ18_RS14255	COG2040	homocysteine
CTZ18_RS14260	COG0531	amino acid
CTZ18_RS14285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTZ18_RS14290	COG0477	Major facilitator Superfamily
CTZ18_RS14365	COG0629	single-stranded DNA binding
CTZ18_RS14410	COG0582	viral genome integration into host DNA
CTZ18_RS14420	COG0405	Gamma-glutamyltransferase
CTZ18_RS14425	COG2814	Major facilitator Superfamily
CTZ18_RS14435	COG2050	protein possibly involved in aromatic compounds catabolism
CTZ18_RS14450	COG1090	epimerase
CTZ18_RS14470	COG0420	3'-5' exonuclease activity
CTZ18_RS14495	COG0735	belongs to the Fur family
CTZ18_RS14500	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CTZ18_RS14525	COG0121	glutamine amidotransferase
CTZ18_RS14540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTZ18_RS14550	COG0210	DNA helicase
CTZ18_RS14555	COG2885	chlorophyll binding
CTZ18_RS14560	COG0204	Acyl-transferase
CTZ18_RS14575	COG2894	cell division
CTZ18_RS14595	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS14600	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CTZ18_RS14600	COG1674	ftsk spoiiie
CTZ18_RS14605	COG0492	ferredoxin-NADP+ reductase activity
CTZ18_RS14610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CTZ18_RS14620	COG0456	acetyltransferase
CTZ18_RS14665	COG1981	membrane
CTZ18_RS14680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTZ18_RS14680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTZ18_RS14700	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS14710	COG0657	acetylesterase activity
CTZ18_RS14720	COG0473	3-isopropylmalate dehydrogenase activity
CTZ18_RS14725	COG0583	DNA-binding transcription factor activity
CTZ18_RS14745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTZ18_RS14770	COG0564	pseudouridine synthase activity
CTZ18_RS14780	COG0358	DNA primase activity
CTZ18_RS14795	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CTZ18_RS14825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTZ18_RS14855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTZ18_RS14865	COG0352	thiamine-phosphate diphosphorylase activity
CTZ18_RS14865	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CTZ18_RS14865	COG0351	phosphomethylpyrimidine kinase
CTZ18_RS14870	COG1652	LysM domain
CTZ18_RS14895	COG1399	metal-binding, possibly nucleic acid-binding protein
CTZ18_RS14900	COG3101	peptidyl-lysine hydroxylation
CTZ18_RS14905	COG0009	L-threonylcarbamoyladenylate synthase
CTZ18_RS14910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CTZ18_RS14915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTZ18_RS14930	COG4106	trans-aconitate 2-methyltransferase activity
CTZ18_RS14945	COG2226	methyltransferase
CTZ18_RS14945	COG0596	Alpha beta hydrolase
CTZ18_RS14945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CTZ18_RS14950	COG1877	trehalose-phosphatase activity
CTZ18_RS14955	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CTZ18_RS14960	COG2223	nitrite transmembrane transporter activity
CTZ18_RS14980	COG1196	nuclear chromosome segregation
CTZ18_RS14990	COG0730	response to heat
CTZ18_RS15005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTZ18_RS15015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTZ18_RS15075	COG0489	protein tyrosine kinase activity
CTZ18_RS15085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTZ18_RS15085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTZ18_RS15115	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CTZ18_RS15120	COG2081	HI0933 family
CTZ18_RS15130	COG0668	transmembrane transport
CTZ18_RS15150	COG0583	DNA-binding transcription factor activity
CTZ18_RS15170	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTZ18_RS15175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTZ18_RS15205	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CTZ18_RS15245	COG0745	RESPONSE REGULATOR receiver
CTZ18_RS15265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CTZ18_RS15275	COG2205	protein histidine kinase activity
CTZ18_RS15345	COG4993	Dehydrogenase
CTZ18_RS15365	COG0384	phenazine biosynthesis protein PhzF
CTZ18_RS15395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CTZ18_RS15410	COG0583	DNA-binding transcription factor activity
CTZ18_RS15440	COG0583	DNA-binding transcription factor activity
CTZ18_RS15460	COG0583	DNA-binding transcription factor activity
CTZ18_RS15465	COG1053	succinate dehydrogenase
CTZ18_RS15475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CTZ18_RS15480	COG2814	Major facilitator Superfamily
CTZ18_RS15485	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS15490	COG0583	DNA-binding transcription factor activity
CTZ18_RS15495	COG1063	alcohol dehydrogenase
CTZ18_RS15525	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTZ18_RS15530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CTZ18_RS15535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CTZ18_RS15550	COG3667	copper resistance
CTZ18_RS15555	COG2132	Multicopper oxidase
CTZ18_RS15565	COG0561	phosphatase activity
CTZ18_RS15570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTZ18_RS15595	COG1214	PFAM Peptidase M22, glycoprotease
CTZ18_RS15645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTZ18_RS15655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CTZ18_RS15660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CTZ18_RS15665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTZ18_RS15725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTZ18_RS15735	COG1846	Transcriptional regulator
CTZ18_RS15740	COG1764	response to oxidative stress
CTZ18_RS15780	COG0037	tRNA processing
CTZ18_RS15790	COG0248	Ppx GppA phosphatase
CTZ18_RS15820	COG0072	phenylalanine-tRNA ligase activity
CTZ18_RS15860	COG1238	metal cluster binding
CTZ18_RS15865	COG0625	glutathione transferase activity
CTZ18_RS15885	COG0318	PFAM AMP-dependent synthetase and ligase
CTZ18_RS15890	COG3028	Belongs to the UPF0307 family
CTZ18_RS15895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CTZ18_RS15915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTZ18_RS15920	COG0617	tRNA 3'-terminal CCA addition
CTZ18_RS15925	COG1555	photosystem II stabilization
CTZ18_RS15930	COG3956	TIGRFAM MazG family protein
CTZ18_RS15940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTZ18_RS15960	COG0784	Response regulator, receiver
CTZ18_RS15960	COG2205	protein histidine kinase activity
CTZ18_RS15960	COG5002	protein histidine kinase activity
CTZ18_RS15965	COG1024	Enoyl-CoA hydratase
CTZ18_RS15990	COG3622	Belongs to the hyi family
CTZ18_RS16020	COG0697	spore germination
CTZ18_RS16030	COG2814	Major facilitator Superfamily
CTZ18_RS16035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTZ18_RS16045	COG0583	DNA-binding transcription factor activity
CTZ18_RS16055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CTZ18_RS16070	COG0084	hydrolase, TatD family'
CTZ18_RS16085	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CTZ18_RS16120	COG0440	acetolactate synthase activity
CTZ18_RS16125	COG0028	Belongs to the TPP enzyme family
CTZ18_RS16150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTZ18_RS16155	COG1136	(ABC) transporter
CTZ18_RS16155	COG0577	efflux transmembrane transporter activity
CTZ18_RS16160	COG1538	Outer membrane efflux protein
CTZ18_RS16175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CTZ18_RS16180	COG1162	GTPase activity
CTZ18_RS16190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CTZ18_RS16210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTZ18_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS16255	COG2986	histidine ammonia-lyase
CTZ18_RS16270	COG0318	PFAM AMP-dependent synthetase and ligase
CTZ18_RS16280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTZ18_RS16325	COG1426	Protein conserved in bacteria
CTZ18_RS16360	COG0793	Belongs to the peptidase S41A family
CTZ18_RS16375	COG2267	carboxylic ester hydrolase activity
CTZ18_RS16385	COG1012	belongs to the aldehyde dehydrogenase family
CTZ18_RS16390	COG3265	gluconokinase activity
CTZ18_RS16400	COG0800	Aldolase
CTZ18_RS16415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTZ18_RS16420	COG0280	phosphate acetyltransferase
CTZ18_RS16420	COG0857	belongs to the CobB CobQ family
CTZ18_RS16425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CTZ18_RS16425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CTZ18_RS16445	COG0740	serine-type endopeptidase activity
CTZ18_RS16455	COG4774	siderophore transport
CTZ18_RS16465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTZ18_RS16475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CTZ18_RS16475	COG2813	Specifically methylates the guanine in position
CTZ18_RS16575	COG0788	formyltetrahydrofolate deformylase activity
CTZ18_RS16600	COG4651	solute:proton antiporter activity
CTZ18_RS16600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CTZ18_RS16620	COG0724	RNA recognition motif
CTZ18_RS16625	COG0210	DNA helicase
CTZ18_RS16650	COG1733	regulation of RNA biosynthetic process
CTZ18_RS16660	COG2900	Belongs to the SlyX family
CTZ18_RS16665	COG0488	(ABC) transporter
CTZ18_RS16670	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS16675	COG1560	Kdo2-lipid A biosynthetic process
CTZ18_RS16685	COG1301	dicarboxylic acid transport
CTZ18_RS16750	COG0473	3-isopropylmalate dehydrogenase activity
CTZ18_RS16815	COG0583	DNA-binding transcription factor activity
CTZ18_RS16825	COG0625	glutathione transferase activity
CTZ18_RS16830	COG2378	regulation of single-species biofilm formation
CTZ18_RS16835	COG0546	phosphoglycolate phosphatase activity
CTZ18_RS16850	COG1530	ribonuclease E activity
CTZ18_RS16855	COG0318	PFAM AMP-dependent synthetase and ligase
CTZ18_RS16870	COG0583	DNA-binding transcription factor activity
CTZ18_RS16875	COG4221	oxidoreductase activity
CTZ18_RS16880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTZ18_RS16890	COG0534	Mate efflux family protein
CTZ18_RS16905	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CTZ18_RS16945	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CTZ18_RS16950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTZ18_RS16965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CTZ18_RS16975	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CTZ18_RS16975	COG0644	oxidoreductase
CTZ18_RS16980	COG0425	Belongs to the sulfur carrier protein TusA family
CTZ18_RS16985	COG4535	Mg2 and Co2 transporter CorC
CTZ18_RS16995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTZ18_RS17015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTZ18_RS17020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CTZ18_RS17020	COG0475	glutathione-regulated potassium exporter activity
CTZ18_RS17025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTZ18_RS17035	COG0484	heat shock protein binding
CTZ18_RS17040	COG0789	Transcriptional regulator
CTZ18_RS17045	COG0598	Magnesium transport protein CorA
CTZ18_RS17060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CTZ18_RS17065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CTZ18_RS17070	COG1074	ATP-dependent DNA helicase activity
CTZ18_RS17075	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CTZ18_RS17095	COG2226	methyltransferase
CTZ18_RS17110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CTZ18_RS17115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CTZ18_RS17130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTZ18_RS17130	COG2111	Na H antiporter
CTZ18_RS17135	COG1006	Multisubunit Na H antiporter MnhC subunit
CTZ18_RS17140	COG0651	ATP synthesis coupled electron transport
CTZ18_RS17145	COG1863	multisubunit Na H antiporter MnhE subunit
CTZ18_RS17150	COG2212	antiporter activity
CTZ18_RS17155	COG1320	monovalent cation:proton antiporter activity
CTZ18_RS17170	COG0195	Participates in both transcription termination and antitermination
CTZ18_RS17220	COG0237	dephospho-CoA kinase activity
CTZ18_RS17230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTZ18_RS17245	COG0497	DNA recombination
CTZ18_RS17255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTZ18_RS17285	COG2169	Transcriptional regulator
CTZ18_RS17285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CTZ18_RS17290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTZ18_RS17365	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CTZ18_RS17380	COG0326	Molecular chaperone. Has ATPase activity
CTZ18_RS17395	COG2056	Na+-H+ antiporter family
CTZ18_RS17400	COG0596	Alpha beta hydrolase
CTZ18_RS17495	COG0546	phosphoglycolate phosphatase activity
CTZ18_RS17500	COG1716	ATPase activity
CTZ18_RS17545	COG0181	hydroxymethylbilane synthase activity
CTZ18_RS17555	COG3275	phosphorelay sensor kinase activity
CTZ18_RS17575	COG1538	Outer membrane efflux protein
CTZ18_RS17580	COG0697	spore germination
CTZ18_RS17605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CTZ18_RS17610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CTZ18_RS17615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTZ18_RS17620	COG0772	Belongs to the SEDS family
CTZ18_RS17645	COG4974	Belongs to the 'phage' integrase family
CTZ18_RS17650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CTZ18_RS17660	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CTZ18_RS17670	COG2197	response regulator
CTZ18_RS17685	COG0793	Belongs to the peptidase S41A family
CTZ18_RS17690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CTZ18_RS17695	COG0795	lipopolysaccharide-transporting ATPase activity
CTZ18_RS17735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTZ18_RS17735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTZ18_RS17745	COG0004	ammonium transporteR
CTZ18_RS17750	COG0347	Belongs to the P(II) protein family
CTZ18_RS17760	COG0606	chelatase, subunit chli
CTZ18_RS17815	COG0659	secondary active sulfate transmembrane transporter activity
CTZ18_RS17820	COG0589	response to stress
CTZ18_RS17850	COG0606	chelatase, subunit chli
CTZ18_RS17855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTZ18_RS17865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTZ18_RS17880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CTZ18_RS17895	COG0318	PFAM AMP-dependent synthetase and ligase
CTZ18_RS17905	COG0477	Major facilitator Superfamily
CTZ18_RS17910	COG2860	membrane
CTZ18_RS17920	COG1253	flavin adenine dinucleotide binding
CTZ18_RS17940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CTZ18_RS17975	COG0655	NAD(P)H dehydrogenase (quinone) activity
CTZ18_RS17985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTZ18_RS18020	COG1309	transcriptional regulator
CTZ18_RS18055	COG0758	DNA mediated transformation
CTZ18_RS18065	COG0697	spore germination
CTZ18_RS18070	COG1309	transcriptional regulator
CTZ18_RS18085	COG0386	Belongs to the glutathione peroxidase family
CTZ18_RS18150	COG1121	(ABC) transporter
CTZ18_RS18155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTZ18_RS18160	COG1280	lysine exporter protein (LysE YggA)
CTZ18_RS18165	COG2837	iron assimilation
CTZ18_RS18175	COG0281	malic enzyme
CTZ18_RS18220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTZ18_RS18220	COG0519	Catalyzes the synthesis of GMP from XMP
CTZ18_RS18225	COG4399	Belongs to the UPF0754 family
CTZ18_RS18230	COG2259	Doxx family
CTZ18_RS18235	COG0586	Pfam SNARE associated Golgi protein
CTZ18_RS18250	COG1192	Involved in chromosome partitioning
CTZ18_RS18260	COG0271	Belongs to the BolA IbaG family
CTZ18_RS18280	COG2267	carboxylic ester hydrolase activity
CTZ18_RS18300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTZ18_RS18300	COG3321	synthase
CTZ18_RS18300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CTZ18_RS18300	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CTZ18_RS18305	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS18315	COG2197	response regulator
CTZ18_RS18325	COG3916	Acyl-homoserine-lactone synthase
CTZ18_RS18330	COG0477	Major facilitator Superfamily
CTZ18_RS18335	COG1024	Enoyl-CoA hydratase
CTZ18_RS18340	COG1024	Enoyl-CoA hydratase
CTZ18_RS18345	COG1960	acyl-CoA dehydrogenase activity
CTZ18_RS18350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CTZ18_RS18370	COG1113	amino acid transport
CTZ18_RS18375	COG1113	amino acid transport
CTZ18_RS18380	COG0251	oxidation-reduction process
CTZ18_RS18420	COG0564	pseudouridine synthase activity
CTZ18_RS18485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CTZ18_RS18500	COG1802	Transcriptional regulator
CTZ18_RS18510	COG1448	Aminotransferase
CTZ18_RS18515	COG0277	FAD linked oxidase domain protein
CTZ18_RS18525	COG2186	Transcriptional regulator
CTZ18_RS18535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTZ18_RS18540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CTZ18_RS18555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CTZ18_RS18565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTZ18_RS18575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTZ18_RS18580	COG0438	transferase activity, transferring glycosyl groups
CTZ18_RS18600	COG1216	Glycosyl transferase, family 2
CTZ18_RS18605	COG5039	Polysaccharide pyruvyl transferase
CTZ18_RS18615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CTZ18_RS18620	COG1596	polysaccharide export
CTZ18_RS18645	COG0728	peptidoglycan biosynthetic process
CTZ18_RS18650	COG3023	N-Acetylmuramoyl-L-alanine amidase
CTZ18_RS18710	COG0546	phosphoglycolate phosphatase activity
CTZ18_RS18715	COG1028	Short-chain dehydrogenase reductase Sdr
CTZ18_RS18735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTZ18_RS18740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTZ18_RS18745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CTZ18_RS18750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTZ18_RS18755	COG1116	anion transmembrane transporter activity
CTZ18_RS18760	COG1309	transcriptional regulator
CTZ18_RS18765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTZ18_RS18775	COG0196	riboflavin kinase activity
CTZ18_RS18780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTZ18_RS18790	COG1047	Peptidyl-prolyl cis-trans
CTZ18_RS18830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CTZ18_RS18835	COG0657	acetylesterase activity
CTZ18_RS18885	COG2951	lytic endotransglycosylase activity
CTZ18_RS18890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CTZ18_RS18910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTZ18_RS18920	COG0671	phosphoesterase, PA-phosphatase related
CTZ18_RS18925	COG0861	Integral membrane protein TerC family
CTZ18_RS18935	COG0754	glutathionylspermidine amidase activity
CTZ18_RS18945	COG0402	S-adenosylhomocysteine deaminase activity
CTZ18_RS18960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CTZ18_RS18965	COG1230	cation diffusion facilitator family transporter
CTZ18_RS18980	COG0706	membrane insertase activity