locus-tag	class	description
H4B45_RS00005	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B45_RS00020	COG2137	regulation of response to DNA damage stimulus
H4B45_RS00035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B45_RS00070	COG0575	Belongs to the CDS family
H4B45_RS00075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4B45_RS00100	COG3852	Histidine kinase
H4B45_RS00105	COG2204	response regulator
H4B45_RS00160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4B45_RS00165	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H4B45_RS00185	COG0697	spore germination
H4B45_RS00190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B45_RS00200	COG0303	'Molybdopterin
H4B45_RS00205	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4B45_RS00205	COG0315	cyclic pyranopterin monophosphate synthase activity
H4B45_RS00220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4B45_RS00225	COG0243	molybdopterin cofactor binding
H4B45_RS00235	COG0243	molybdopterin cofactor binding
H4B45_RS00240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B45_RS00245	COG2146	nitrite reductase [NAD(P)H] activity
H4B45_RS00245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B45_RS00255	COG0745	RESPONSE REGULATOR receiver
H4B45_RS00260	COG1116	anion transmembrane transporter activity
H4B45_RS00260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B45_RS00275	COG0511	ligase activity, forming carbon-carbon bonds
H4B45_RS00290	COG2814	Major facilitator Superfamily
H4B45_RS00315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4B45_RS00430	COG0592	DNA-directed DNA polymerase activity
H4B45_RS00470	COG2026	Addiction module toxin, RelE StbE family
H4B45_RS00665	COG1484	DNA-dependent DNA replication
H4B45_RS00760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4B45_RS00810	COG0069	glutamate synthase activity
H4B45_RS00830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4B45_RS00840	COG1454	alcohol dehydrogenase
H4B45_RS00845	COG0824	Thioesterase
H4B45_RS00925	COG2963	transposase activity
H4B45_RS00935	COG1522	sequence-specific DNA binding
H4B45_RS00940	COG3135	benzoate transporter
H4B45_RS00950	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4B45_RS00975	COG0589	response to stress
H4B45_RS00980	COG0488	(ABC) transporter
H4B45_RS01000	COG4773	Receptor
H4B45_RS01030	COG0668	transmembrane transport
H4B45_RS01040	COG1309	transcriptional regulator
H4B45_RS01055	COG1605	Chorismate mutase
H4B45_RS01095	COG0308	aminopeptidase N
H4B45_RS01115	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H4B45_RS01125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4B45_RS01130	COG1454	alcohol dehydrogenase
H4B45_RS01150	COG0531	amino acid
H4B45_RS01155	COG4303	Ethanolamine ammonia lyase large subunit
H4B45_RS01160	COG4302	ethanolamine ammonia-lyase activity
H4B45_RS01165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4B45_RS01165	COG0519	Catalyzes the synthesis of GMP from XMP
H4B45_RS01170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4B45_RS01180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B45_RS01195	COG0697	spore germination
H4B45_RS01200	COG1923	regulation of RNA biosynthetic process
H4B45_RS01210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4B45_RS01215	COG0802	atpase or kinase
H4B45_RS01235	COG1187	pseudouridine synthase activity
H4B45_RS01250	COG0583	DNA-binding transcription factor activity
H4B45_RS01265	COG2814	Major facilitator Superfamily
H4B45_RS01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4B45_RS01295	COG0729	surface antigen
H4B45_RS01315	COG0174	glutamine synthetase
H4B45_RS01320	COG0745	RESPONSE REGULATOR receiver
H4B45_RS01325	COG2205	protein histidine kinase activity
H4B45_RS01335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4B45_RS01340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4B45_RS01350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4B45_RS01365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS01370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B45_RS01375	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS01405	COG0583	DNA-binding transcription factor activity
H4B45_RS01420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B45_RS01430	COG3658	cytochrome
H4B45_RS01435	COG1215	transferase activity, transferring glycosyl groups
H4B45_RS01440	COG0726	polysaccharide deacetylase
H4B45_RS01440	COG1649	PFAM Uncharacterised BCR, COG1649
H4B45_RS01465	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4B45_RS01470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4B45_RS01480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4B45_RS01505	COG0305	Participates in initiation and elongation during chromosome replication
H4B45_RS01510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4B45_RS01520	COG1305	Transglutaminase-like
H4B45_RS01530	COG2308	Evidence 4 Homologs of previously reported genes of
H4B45_RS01560	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H4B45_RS01565	COG0138	bifunctional purine biosynthesis protein purh
H4B45_RS01570	COG0151	Belongs to the GarS family
H4B45_RS01575	COG1464	Belongs to the NlpA lipoprotein family
H4B45_RS01580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4B45_RS01585	COG2011	ABC-type metal ion transport system permease component
H4B45_RS01590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B45_RS01600	COG1301	dicarboxylic acid transport
H4B45_RS01635	COG1794	racemase activity, acting on amino acids and derivatives
H4B45_RS01645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4B45_RS01645	COG3008	intermembrane lipid transfer
H4B45_RS01650	COG2995	paraquat-inducible protein a
H4B45_RS01680	COG1051	belongs to the nudix hydrolase family
H4B45_RS01685	COG0477	Major facilitator Superfamily
H4B45_RS01730	COG2186	Transcriptional regulator
H4B45_RS01740	COG0786	glutamate:sodium symporter activity
H4B45_RS01745	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4B45_RS01770	COG3111	PFAM Bacterial OB fold (BOF) protein
H4B45_RS01855	COG2831	hemolysin activation secretion protein
H4B45_RS01880	COG0515	serine threonine protein kinase
H4B45_RS01880	COG2815	serine threonine protein kinase
H4B45_RS01910	COG1610	YqeY-like protein
H4B45_RS01915	COG4783	chaperone-mediated protein folding
H4B45_RS01940	COG1286	toxin biosynthetic process
H4B45_RS01970	COG0778	Nitroreductase
H4B45_RS01980	COG0513	Belongs to the DEAD box helicase family
H4B45_RS02000	COG2363	Small membrane protein
H4B45_RS02030	COG1234	tRNA 3'-trailer cleavage
H4B45_RS02035	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4B45_RS02045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4B45_RS02055	COG2819	hydrolase of the alpha beta superfamily
H4B45_RS02060	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS02065	COG1301	dicarboxylic acid transport
H4B45_RS02070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4B45_RS02075	COG3139	Protein of unknown function (DUF1315)
H4B45_RS02080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4B45_RS02085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4B45_RS02095	COG0494	nUDIX hydrolase
H4B45_RS02105	COG0642	Histidine kinase
H4B45_RS02120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4B45_RS02130	COG1720	tRNA m6t6A37 methyltransferase activity
H4B45_RS02140	COG0384	phenazine biosynthesis protein PhzF
H4B45_RS02145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B45_RS02150	COG0826	peptidase U32
H4B45_RS02155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B45_RS02165	COG4598	ABC transporter
H4B45_RS02170	COG4160	amino acid transport
H4B45_RS02175	COG4215	(ABC) transporter
H4B45_RS02190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS02235	COG1131	(ABC) transporter
H4B45_RS02240	COG0842	Transport permease protein
H4B45_RS02255	COG0772	Belongs to the SEDS family
H4B45_RS02260	COG2951	lytic endotransglycosylase activity
H4B45_RS02285	COG2207	Transcriptional regulator
H4B45_RS02300	COG0052	Belongs to the universal ribosomal protein uS2 family
H4B45_RS02305	COG0024	Methionine aminopeptidase
H4B45_RS02315	COG2223	nitrite transmembrane transporter activity
H4B45_RS02325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B45_RS02330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4B45_RS02335	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS02350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4B45_RS02355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4B45_RS02360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4B45_RS02380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4B45_RS02385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4B45_RS02390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4B45_RS02425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4B45_RS02435	COG0174	glutamine synthetase
H4B45_RS02450	COG0512	Glutamine amidotransferase of anthranilate synthase
H4B45_RS02455	COG0308	aminopeptidase N
H4B45_RS02485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4B45_RS02495	COG0302	gtp cyclohydrolase
H4B45_RS02520	COG3739	integral membrane protein
H4B45_RS02540	COG2977	Belongs to the P-Pant transferase superfamily
H4B45_RS02545	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H4B45_RS02550	COG1132	(ABC) transporter
H4B45_RS02555	COG1132	(ABC) transporter
H4B45_RS02565	COG1535	isochorismatase
H4B45_RS02565	COG3433	isochorismatase activity
H4B45_RS02570	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4B45_RS02575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B45_RS02585	COG4774	siderophore transport
H4B45_RS02590	COG4607	ABC-type enterochelin transport system periplasmic component
H4B45_RS02595	COG4604	ABC transporter, ATP-binding protein
H4B45_RS02600	COG4605	iron ion homeostasis
H4B45_RS02605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4B45_RS02610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B45_RS02625	COG2964	Protein conserved in bacteria
H4B45_RS02635	COG1741	Belongs to the pirin family
H4B45_RS02650	COG1309	transcriptional regulator
H4B45_RS02660	COG4372	Transposase
H4B45_RS02680	COG4948	Mandelate Racemase Muconate Lactonizing
H4B45_RS02685	COG2814	Major facilitator Superfamily
H4B45_RS02720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4B45_RS02720	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4B45_RS02725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B45_RS02730	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS02745	COG0477	Major facilitator Superfamily
H4B45_RS02750	COG0006	proline dipeptidase activity
H4B45_RS02755	COG1902	pentaerythritol trinitrate reductase activity
H4B45_RS02760	COG0583	DNA-binding transcription factor activity
H4B45_RS02770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4B45_RS02780	COG0596	Alpha beta hydrolase
H4B45_RS02795	COG0583	DNA-binding transcription factor activity
H4B45_RS02800	COG1335	isochorismatase
H4B45_RS02840	COG2879	small protein
H4B45_RS02845	COG1966	Carbon starvation protein
H4B45_RS02865	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4B45_RS02890	COG1067	ATP-dependent peptidase activity
H4B45_RS02895	COG0583	DNA-binding transcription factor activity
H4B45_RS02920	COG1686	Belongs to the peptidase S11 family
H4B45_RS02925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4B45_RS02960	COG0616	signal peptide processing
H4B45_RS02965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4B45_RS02975	COG0573	inorganic phosphate transmembrane transporter activity
H4B45_RS02980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4B45_RS02985	COG1113	amino acid transport
H4B45_RS02990	COG3961	Belongs to the TPP enzyme family
H4B45_RS02995	COG1522	sequence-specific DNA binding
H4B45_RS03005	COG0076	glutamate decarboxylase activity
H4B45_RS03010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4B45_RS03025	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS03035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B45_RS03070	COG0352	thiamine-phosphate diphosphorylase activity
H4B45_RS03095	COG0612	Peptidase, M16
H4B45_RS03105	COG1823	symporter activity
H4B45_RS03110	COG0583	DNA-binding transcription factor activity
H4B45_RS03115	COG0477	Major facilitator Superfamily
H4B45_RS03140	COG1187	pseudouridine synthase activity
H4B45_RS03155	COG1686	Belongs to the peptidase S11 family
H4B45_RS03160	COG1252	NADH dehydrogenase
H4B45_RS03170	COG0415	Belongs to the DNA photolyase family
H4B45_RS03185	COG1215	transferase activity, transferring glycosyl groups
H4B45_RS03215	COG2070	2-Nitropropane dioxygenase
H4B45_RS03270	COG0556	nucleotide-excision repair
H4B45_RS03290	COG0436	Aminotransferase
H4B45_RS03300	COG0443	Heat shock 70 kDa protein
H4B45_RS03330	COG4221	oxidoreductase activity
H4B45_RS03340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4B45_RS03345	COG1381	Involved in DNA repair and RecF pathway recombination
H4B45_RS03355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4B45_RS03370	COG0681	Belongs to the peptidase S26 family
H4B45_RS03385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4B45_RS03405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4B45_RS03410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4B45_RS03415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4B45_RS03425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4B45_RS03430	COG4208	sulfate ABC transporter
H4B45_RS03435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4B45_RS03440	COG0583	DNA-binding transcription factor activity
H4B45_RS03445	COG4625	pathogenesis
H4B45_RS03460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4B45_RS03475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4B45_RS03485	COG1056	cytidyltransferase-related domain
H4B45_RS03485	COG1051	belongs to the nudix hydrolase family
H4B45_RS03490	COG1024	Enoyl-CoA hydratase
H4B45_RS03500	COG2814	Major facilitator Superfamily
H4B45_RS03505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4B45_RS03505	COG0047	phosphoribosylformylglycinamidine synthase activity
H4B45_RS03525	COG1473	amidohydrolase
H4B45_RS03530	COG0824	Thioesterase
H4B45_RS03550	COG0823	Involved in the tonB-independent uptake of proteins
H4B45_RS03570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4B45_RS03590	COG2963	transposase activity
H4B45_RS03620	COG0628	permease
H4B45_RS03630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4B45_RS03635	COG0596	Alpha beta hydrolase
H4B45_RS03640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4B45_RS03640	COG0616	signal peptide processing
H4B45_RS03650	COG2333	competence protein COMEC
H4B45_RS03650	COG0658	competence protein
H4B45_RS03655	COG1136	(ABC) transporter
H4B45_RS03660	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4B45_RS03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS03715	COG0463	Glycosyl transferase, family 2
H4B45_RS03745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4B45_RS03750	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS03760	COG0019	diaminopimelate decarboxylase activity
H4B45_RS03770	COG1113	amino acid transport
H4B45_RS03785	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4B45_RS03795	COG3339	Conserved Protein
H4B45_RS03800	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4B45_RS03805	COG0243	molybdopterin cofactor binding
H4B45_RS03810	COG1929	Belongs to the glycerate kinase type-1 family
H4B45_RS03825	COG0778	Nitroreductase
H4B45_RS03845	COG3811	Belongs to the UPF0386 family
H4B45_RS03870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4B45_RS03890	COG0741	lytic transglycosylase activity
H4B45_RS03910	COG0584	glycerophosphoryl diester phosphodiesterase
H4B45_RS03915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B45_RS03940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4B45_RS03945	COG1597	lipid kinase activity
H4B45_RS03960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4B45_RS03965	COG0477	Major facilitator Superfamily
H4B45_RS04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4B45_RS04020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4B45_RS04045	COG0505	Belongs to the CarA family
H4B45_RS04065	COG0589	response to stress
H4B45_RS04080	COG2843	Capsule synthesis protein
H4B45_RS04105	COG2321	neutral zinc metallopeptidase
H4B45_RS04110	COG2354	Protein conserved in bacteria
H4B45_RS04130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B45_RS04155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4B45_RS04160	COG1053	succinate dehydrogenase
H4B45_RS04165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4B45_RS04170	COG2009	succinate dehydrogenase
H4B45_RS04210	COG2921	Belongs to the UPF0250 family
H4B45_RS04215	COG0321	lipoyl(octanoyl) transferase activity
H4B45_RS04230	COG0531	amino acid
H4B45_RS04240	COG1733	regulation of RNA biosynthetic process
H4B45_RS04245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4B45_RS04250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4B45_RS04250	COG1648	precorrin-2 dehydrogenase activity
H4B45_RS04265	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H4B45_RS04295	COG0671	phosphoesterase, PA-phosphatase related
H4B45_RS04300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS04310	COG1538	Outer membrane efflux protein
H4B45_RS04315	COG0393	Putative heavy-metal-binding
H4B45_RS04320	COG0393	Putative heavy-metal-binding
H4B45_RS04330	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS04340	COG0525	valine-tRNA ligase activity
H4B45_RS04345	COG2226	methyltransferase
H4B45_RS04360	COG0583	DNA-binding transcription factor activity
H4B45_RS04365	COG0004	ammonium transporteR
H4B45_RS04375	COG0642	Histidine kinase
H4B45_RS04380	COG0745	RESPONSE REGULATOR receiver
H4B45_RS04385	COG2194	sulfuric ester hydrolase activity
H4B45_RS04420	COG2963	transposase activity
H4B45_RS04435	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4B45_RS04450	COG2315	Protein conserved in bacteria
H4B45_RS04455	COG0142	geranyltranstransferase activity
H4B45_RS04460	COG2828	Protein conserved in bacteria
H4B45_RS04465	COG1113	amino acid transport
H4B45_RS04485	COG2963	transposase activity
H4B45_RS04515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4B45_RS04525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4B45_RS04530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4B45_RS04535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4B45_RS04595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4B45_RS04605	COG1846	Transcriptional regulator
H4B45_RS04610	COG1764	response to oxidative stress
H4B45_RS04650	COG0037	tRNA processing
H4B45_RS04660	COG0248	Ppx GppA phosphatase
H4B45_RS04690	COG0072	phenylalanine-tRNA ligase activity
H4B45_RS04730	COG1238	metal cluster binding
H4B45_RS04735	COG0625	glutathione transferase activity
H4B45_RS04750	COG0318	PFAM AMP-dependent synthetase and ligase
H4B45_RS04755	COG3028	Belongs to the UPF0307 family
H4B45_RS04760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4B45_RS04780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4B45_RS04785	COG0617	tRNA 3'-terminal CCA addition
H4B45_RS04790	COG1555	photosystem II stabilization
H4B45_RS04795	COG3956	TIGRFAM MazG family protein
H4B45_RS04805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4B45_RS04825	COG0784	Response regulator, receiver
H4B45_RS04825	COG2205	protein histidine kinase activity
H4B45_RS04825	COG5002	protein histidine kinase activity
H4B45_RS04830	COG1024	Enoyl-CoA hydratase
H4B45_RS04835	COG2084	Dehydrogenase
H4B45_RS04840	COG3622	Belongs to the hyi family
H4B45_RS04870	COG0697	spore germination
H4B45_RS04880	COG2814	Major facilitator Superfamily
H4B45_RS04885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4B45_RS04895	COG0583	DNA-binding transcription factor activity
H4B45_RS04905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4B45_RS04915	COG0084	hydrolase, TatD family'
H4B45_RS04930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4B45_RS04960	COG0440	acetolactate synthase activity
H4B45_RS04965	COG0028	Belongs to the TPP enzyme family
H4B45_RS04990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS04995	COG1136	(ABC) transporter
H4B45_RS04995	COG0577	efflux transmembrane transporter activity
H4B45_RS05000	COG1538	Outer membrane efflux protein
H4B45_RS05015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4B45_RS05020	COG1162	GTPase activity
H4B45_RS05030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4B45_RS05070	COG1426	Protein conserved in bacteria
H4B45_RS05105	COG0793	Belongs to the peptidase S41A family
H4B45_RS05120	COG2267	carboxylic ester hydrolase activity
H4B45_RS05130	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS05135	COG3265	gluconokinase activity
H4B45_RS05145	COG0800	Aldolase
H4B45_RS05155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4B45_RS05160	COG0857	belongs to the CobB CobQ family
H4B45_RS05160	COG0280	phosphate acetyltransferase
H4B45_RS05165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4B45_RS05165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4B45_RS05185	COG0740	serine-type endopeptidase activity
H4B45_RS05195	COG4774	siderophore transport
H4B45_RS05205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4B45_RS05215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B45_RS05215	COG2813	Specifically methylates the guanine in position
H4B45_RS05315	COG0788	formyltetrahydrofolate deformylase activity
H4B45_RS05340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B45_RS05340	COG4651	solute:proton antiporter activity
H4B45_RS05360	COG0724	RNA recognition motif
H4B45_RS05365	COG0210	DNA helicase
H4B45_RS05390	COG1733	regulation of RNA biosynthetic process
H4B45_RS05400	COG2900	Belongs to the SlyX family
H4B45_RS05405	COG0488	(ABC) transporter
H4B45_RS05410	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS05415	COG1560	Kdo2-lipid A biosynthetic process
H4B45_RS05425	COG1301	dicarboxylic acid transport
H4B45_RS05480	COG0473	3-isopropylmalate dehydrogenase activity
H4B45_RS05545	COG0583	DNA-binding transcription factor activity
H4B45_RS05555	COG0625	glutathione transferase activity
H4B45_RS05560	COG2378	regulation of single-species biofilm formation
H4B45_RS05565	COG0546	phosphoglycolate phosphatase activity
H4B45_RS05575	COG1530	ribonuclease E activity
H4B45_RS05580	COG0318	PFAM AMP-dependent synthetase and ligase
H4B45_RS05595	COG0583	DNA-binding transcription factor activity
H4B45_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS05605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4B45_RS05615	COG0534	Mate efflux family protein
H4B45_RS05630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4B45_RS05665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4B45_RS05670	COG0583	DNA-binding transcription factor activity
H4B45_RS05690	COG2030	dehydratase
H4B45_RS05710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4B45_RS05745	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B45_RS05745	COG0493	'glutamate synthase
H4B45_RS05755	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H4B45_RS05760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B45_RS05775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4B45_RS05785	COG0644	oxidoreductase
H4B45_RS05785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H4B45_RS05795	COG0425	Belongs to the sulfur carrier protein TusA family
H4B45_RS05800	COG4535	Mg2 and Co2 transporter CorC
H4B45_RS05810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B45_RS05830	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4B45_RS05835	COG0475	glutathione-regulated potassium exporter activity
H4B45_RS05835	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B45_RS05850	COG0484	heat shock protein binding
H4B45_RS05855	COG0789	Transcriptional regulator
H4B45_RS05860	COG0598	Magnesium transport protein CorA
H4B45_RS05875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4B45_RS05880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4B45_RS05885	COG1074	ATP-dependent DNA helicase activity
H4B45_RS05890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4B45_RS05910	COG2226	methyltransferase
H4B45_RS05925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B45_RS05930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4B45_RS05945	COG2111	Na H antiporter
H4B45_RS05945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4B45_RS05950	COG1006	Multisubunit Na H antiporter MnhC subunit
H4B45_RS05955	COG0651	ATP synthesis coupled electron transport
H4B45_RS05960	COG1863	multisubunit Na H antiporter MnhE subunit
H4B45_RS05965	COG2212	antiporter activity
H4B45_RS05970	COG1320	monovalent cation:proton antiporter activity
H4B45_RS05985	COG0195	Participates in both transcription termination and antitermination
H4B45_RS06035	COG0237	dephospho-CoA kinase activity
H4B45_RS06045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4B45_RS06060	COG0497	DNA recombination
H4B45_RS06070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4B45_RS06100	COG2169	Transcriptional regulator
H4B45_RS06100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4B45_RS06105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4B45_RS06155	COG0789	Transcriptional regulator
H4B45_RS06165	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4B45_RS06180	COG0326	Molecular chaperone. Has ATPase activity
H4B45_RS06195	COG2056	Na+-H+ antiporter family
H4B45_RS06295	COG0546	phosphoglycolate phosphatase activity
H4B45_RS06300	COG1716	ATPase activity
H4B45_RS06345	COG0181	hydroxymethylbilane synthase activity
H4B45_RS06355	COG3275	phosphorelay sensor kinase activity
H4B45_RS06375	COG1538	Outer membrane efflux protein
H4B45_RS06380	COG0697	spore germination
H4B45_RS06405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4B45_RS06410	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4B45_RS06415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4B45_RS06420	COG0772	Belongs to the SEDS family
H4B45_RS06445	COG4974	Belongs to the 'phage' integrase family
H4B45_RS06450	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B45_RS06460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4B45_RS06470	COG2197	response regulator
H4B45_RS06485	COG0793	Belongs to the peptidase S41A family
H4B45_RS06490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H4B45_RS06495	COG0795	lipopolysaccharide-transporting ATPase activity
H4B45_RS06535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4B45_RS06535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4B45_RS06545	COG0004	ammonium transporteR
H4B45_RS06550	COG0347	Belongs to the P(II) protein family
H4B45_RS06560	COG0606	chelatase, subunit chli
H4B45_RS06630	COG2132	Multicopper oxidase
H4B45_RS06645	COG2205	protein histidine kinase activity
H4B45_RS06650	COG2217	Heavy metal translocating P-type atpase
H4B45_RS06670	COG2963	transposase activity
H4B45_RS06710	COG0606	chelatase, subunit chli
H4B45_RS06715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B45_RS06720	COG0235	Class ii aldolase
H4B45_RS06725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B45_RS06745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4B45_RS06760	COG0318	PFAM AMP-dependent synthetase and ligase
H4B45_RS06770	COG0477	Major facilitator Superfamily
H4B45_RS06775	COG2860	membrane
H4B45_RS06780	COG3012	SEC-C Motif Domain Protein
H4B45_RS06785	COG1253	flavin adenine dinucleotide binding
H4B45_RS06795	COG0477	Major facilitator Superfamily
H4B45_RS06805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4B45_RS06840	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS06850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4B45_RS06885	COG1309	transcriptional regulator
H4B45_RS06920	COG0758	DNA mediated transformation
H4B45_RS06930	COG0697	spore germination
H4B45_RS06935	COG1309	transcriptional regulator
H4B45_RS06950	COG0386	Belongs to the glutathione peroxidase family
H4B45_RS07020	COG1121	(ABC) transporter
H4B45_RS07025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4B45_RS07030	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS07035	COG2837	iron assimilation
H4B45_RS07045	COG0281	malic enzyme
H4B45_RS07090	COG0519	Catalyzes the synthesis of GMP from XMP
H4B45_RS07090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4B45_RS07095	COG4399	Belongs to the UPF0754 family
H4B45_RS07100	COG2259	Doxx family
H4B45_RS07105	COG0586	Pfam SNARE associated Golgi protein
H4B45_RS07120	COG1192	Involved in chromosome partitioning
H4B45_RS07130	COG0271	Belongs to the BolA IbaG family
H4B45_RS07170	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H4B45_RS07170	COG3321	synthase
H4B45_RS07170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4B45_RS07170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4B45_RS07175	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS07185	COG2197	response regulator
H4B45_RS07195	COG3916	Acyl-homoserine-lactone synthase
H4B45_RS07200	COG0477	Major facilitator Superfamily
H4B45_RS07205	COG1024	Enoyl-CoA hydratase
H4B45_RS07210	COG1024	Enoyl-CoA hydratase
H4B45_RS07215	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS07220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B45_RS07240	COG1113	amino acid transport
H4B45_RS07245	COG1113	amino acid transport
H4B45_RS07250	COG0251	oxidation-reduction process
H4B45_RS07290	COG0564	pseudouridine synthase activity
H4B45_RS07380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4B45_RS07395	COG1802	Transcriptional regulator
H4B45_RS07405	COG1448	Aminotransferase
H4B45_RS07410	COG0277	FAD linked oxidase domain protein
H4B45_RS07420	COG2186	Transcriptional regulator
H4B45_RS07430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4B45_RS07450	COG2963	transposase activity
H4B45_RS07455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4B45_RS07470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4B45_RS07475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4B45_RS07480	COG1216	Glycosyl transferase, family 2
H4B45_RS07505	COG2244	polysaccharide biosynthetic process
H4B45_RS07510	COG1083	cytidylyl-transferase
H4B45_RS07515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4B45_RS07525	COG2089	acid synthase
H4B45_RS07530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H4B45_RS07535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4B45_RS07545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4B45_RS07575	COG0728	peptidoglycan biosynthetic process
H4B45_RS07580	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4B45_RS07635	COG0546	phosphoglycolate phosphatase activity
H4B45_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS07660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B45_RS07665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B45_RS07670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B45_RS07675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4B45_RS07680	COG1116	anion transmembrane transporter activity
H4B45_RS07685	COG1309	transcriptional regulator
H4B45_RS07690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4B45_RS07700	COG0196	riboflavin kinase activity
H4B45_RS07705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4B45_RS07715	COG1047	Peptidyl-prolyl cis-trans
H4B45_RS07755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4B45_RS07760	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H4B45_RS07765	COG0596	Alpha beta hydrolase
H4B45_RS07790	COG0488	(ABC) transporter
H4B45_RS07795	COG0586	Pfam SNARE associated Golgi protein
H4B45_RS07805	COG0187	DNA topoisomerase II activity
H4B45_RS07815	COG0592	DNA-directed DNA polymerase activity
H4B45_RS07845	COG0706	membrane insertase activity
H4B45_RS07860	COG1230	cation diffusion facilitator family transporter
H4B45_RS07865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B45_RS07880	COG0402	S-adenosylhomocysteine deaminase activity
H4B45_RS07890	COG0754	glutathionylspermidine amidase activity
H4B45_RS07900	COG0861	Integral membrane protein TerC family
H4B45_RS07905	COG0671	phosphoesterase, PA-phosphatase related
H4B45_RS07915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4B45_RS07930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4B45_RS07935	COG2951	lytic endotransglycosylase activity
H4B45_RS07985	COG0657	acetylesterase activity
H4B45_RS07990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4B45_RS08030	COG0733	neurotransmitter:sodium symporter activity
H4B45_RS08065	COG0583	DNA-binding transcription factor activity
H4B45_RS08070	COG2233	PERMEase
H4B45_RS08085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS08120	COG2814	Major facilitator Superfamily
H4B45_RS08125	COG0656	L-ascorbic acid biosynthetic process
H4B45_RS08130	COG0583	DNA-binding transcription factor activity
H4B45_RS08145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B45_RS08150	COG1064	alcohol dehydrogenase
H4B45_RS08155	COG2818	Glycosylase
H4B45_RS08170	COG1194	a g-specific adenine glycosylase
H4B45_RS08190	COG2983	Belongs to the UPF0260 family
H4B45_RS08195	COG2133	pyrroloquinoline quinone binding
H4B45_RS08200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4B45_RS08205	COG2116	formate transmembrane transporter activity
H4B45_RS08225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B45_RS08230	COG1335	isochorismatase
H4B45_RS08235	COG0385	Bile acid
H4B45_RS08245	COG1683	Conserved Protein
H4B45_RS08265	COG0625	glutathione transferase activity
H4B45_RS08275	COG1113	amino acid transport
H4B45_RS08285	COG0523	cobalamin synthesis protein
H4B45_RS08295	COG2188	Transcriptional regulator
H4B45_RS08325	COG1192	Involved in chromosome partitioning
H4B45_RS08420	COG3173	Aminoglycoside phosphotransferase
H4B45_RS08425	COG0488	(ABC) transporter
H4B45_RS08440	COG0482	sulfurtransferase activity
H4B45_RS08490	COG3039	Transposase
H4B45_RS08625	COG0616	signal peptide processing
H4B45_RS08715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4B45_RS08750	COG2963	transposase activity
H4B45_RS08775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4B45_RS08825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4B45_RS08830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4B45_RS08840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4B45_RS08845	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4B45_RS08930	COG0534	Mate efflux family protein
H4B45_RS08935	COG0436	Aminotransferase
H4B45_RS08940	COG2733	membrane
H4B45_RS08955	COG2918	glutathione biosynthetic process
H4B45_RS08970	COG3179	chitinase
H4B45_RS08985	COG3150	esterase
H4B45_RS08995	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H4B45_RS09005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B45_RS09015	COG2233	PERMEase
H4B45_RS09020	COG2351	hydroxyisourate hydrolase activity
H4B45_RS09055	COG3706	GGDEF domain
H4B45_RS09070	COG1393	Belongs to the ArsC family
H4B45_RS09075	COG0708	Exodeoxyribonuclease III
H4B45_RS09100	COG0189	ligase activity
H4B45_RS09120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4B45_RS09130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4B45_RS09145	COG4942	peptidase
H4B45_RS09155	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4B45_RS09165	COG2119	membrane
H4B45_RS09170	COG4774	siderophore transport
H4B45_RS09175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS09175	COG0426	domain, Protein
H4B45_RS09200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4B45_RS09225	COG1902	pentaerythritol trinitrate reductase activity
H4B45_RS09230	COG1519	Transferase
H4B45_RS09235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4B45_RS09240	COG0668	transmembrane transport
H4B45_RS09250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B45_RS09255	COG1335	isochorismatase
H4B45_RS09260	COG1522	sequence-specific DNA binding
H4B45_RS09285	COG2198	Histidine kinase
H4B45_RS09285	COG0784	Response regulator, receiver
H4B45_RS09285	COG2205	protein histidine kinase activity
H4B45_RS09290	COG3162	membrane
H4B45_RS09295	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4B45_RS09305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B45_RS09325	COG1309	transcriptional regulator
H4B45_RS09345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4B45_RS09345	COG0351	phosphomethylpyrimidine kinase
H4B45_RS09345	COG0352	thiamine-phosphate diphosphorylase activity
H4B45_RS09355	COG2814	Major facilitator Superfamily
H4B45_RS09370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4B45_RS09380	COG1113	amino acid transport
H4B45_RS09390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4B45_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS09405	COG1335	isochorismatase
H4B45_RS09445	COG1733	regulation of RNA biosynthetic process
H4B45_RS09450	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS09510	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4B45_RS09535	COG1132	(ABC) transporter
H4B45_RS09555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4B45_RS09585	COG0427	acetyl-CoA hydrolase
H4B45_RS09610	COG0659	secondary active sulfate transmembrane transporter activity
H4B45_RS09615	COG4221	oxidoreductase activity
H4B45_RS09625	COG0488	(ABC) transporter
H4B45_RS09690	COG0833	amino acid
H4B45_RS09735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4B45_RS09740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4B45_RS09755	COG2226	methyltransferase
H4B45_RS09805	COG0067	glutamate synthase
H4B45_RS09805	COG0069	glutamate synthase activity
H4B45_RS09805	COG0070	glutamate synthase
H4B45_RS09810	COG0493	'glutamate synthase
H4B45_RS09820	COG1704	LemA family
H4B45_RS09825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H4B45_RS09845	COG3307	-O-antigen
H4B45_RS09865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4B45_RS09880	COG0194	GDP metabolic process
H4B45_RS09930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4B45_RS09950	COG5380	lipid catabolic process
H4B45_RS09955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4B45_RS09980	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4B45_RS09985	COG0277	FAD linked oxidase domain protein
H4B45_RS10000	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H4B45_RS10005	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS10020	COG1289	transmembrane transporter activity
H4B45_RS10030	COG0628	permease
H4B45_RS10035	COG1192	Involved in chromosome partitioning
H4B45_RS10065	COG0833	amino acid
H4B45_RS10070	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4B45_RS10075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4B45_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS10125	COG0583	DNA-binding transcription factor activity
H4B45_RS10175	COG0517	IMP dehydrogenase activity
H4B45_RS10180	COG1983	PspC domain protein
H4B45_RS10190	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS10205	COG0408	coproporphyrinogen oxidase activity
H4B45_RS10225	COG0513	Belongs to the DEAD box helicase family
H4B45_RS10235	COG1127	ABC transporter
H4B45_RS10240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4B45_RS10250	COG2854	intermembrane phospholipid transfer
H4B45_RS10260	COG0598	Magnesium transport protein CorA
H4B45_RS10270	COG0494	nUDIX hydrolase
H4B45_RS10275	COG1040	competence protein
H4B45_RS10280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4B45_RS10300	COG1946	Acyl-CoA thioesterase
H4B45_RS10305	COG1301	dicarboxylic acid transport
H4B45_RS10320	COG1959	2 iron, 2 sulfur cluster binding
H4B45_RS10325	COG1017	nitric oxide dioxygenase activity
H4B45_RS10325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B45_RS10335	COG0433	COG0433 Predicted ATPase
H4B45_RS10340	COG0626	cystathionine gamma-synthase activity
H4B45_RS10495	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS10500	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4B45_RS10530	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H4B45_RS10535	COG0339	signal peptide processing
H4B45_RS10540	COG0557	exoribonuclease II activity
H4B45_RS10585	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4B45_RS10590	COG2169	Transcriptional regulator
H4B45_RS10595	COG0697	spore germination
H4B45_RS10600	COG1295	ribonuclease BN
H4B45_RS10635	COG1702	phosphate starvation-inducible protein PhoH
H4B45_RS10645	COG0741	lytic transglycosylase activity
H4B45_RS10645	COG1196	nuclear chromosome segregation
H4B45_RS10645	COG0739	heme binding
H4B45_RS10675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4B45_RS10680	COG1183	phosphatidylcholine synthase activity
H4B45_RS10725	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS10730	COG1309	transcriptional regulator
H4B45_RS10745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4B45_RS10750	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS10770	COG2969	positive regulation of protein catabolic process
H4B45_RS10780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4B45_RS10790	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4B45_RS10795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4B45_RS10800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4B45_RS10820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4B45_RS10830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4B45_RS10835	COG1408	metallophosphoesterase
H4B45_RS10845	COG2199	diguanylate cyclase activity
H4B45_RS10905	COG1607	acyl-coa hydrolase
H4B45_RS10935	COG2350	Protein conserved in bacteria
H4B45_RS10945	COG0613	PHP domain protein
H4B45_RS10950	COG3781	membrane
H4B45_RS10960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4B45_RS10965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4B45_RS10975	COG1862	Preprotein translocase
H4B45_RS11005	COG2205	protein histidine kinase activity
H4B45_RS11010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4B45_RS11030	COG0726	polysaccharide deacetylase
H4B45_RS11035	COG0463	Glycosyl transferase, family 2
H4B45_RS11040	COG0438	transferase activity, transferring glycosyl groups
H4B45_RS11105	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS11110	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS11120	COG2205	protein histidine kinase activity
H4B45_RS11125	COG0745	RESPONSE REGULATOR receiver
H4B45_RS11130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4B45_RS11150	COG2096	Adenosyltransferase
H4B45_RS11200	COG0285	dihydrofolate synthase activity
H4B45_RS11220	COG0450	alkyl hydroperoxide reductase
H4B45_RS11235	COG0477	Major facilitator Superfamily
H4B45_RS11240	COG1272	protein, Hemolysin III
H4B45_RS11270	COG0183	Belongs to the thiolase family
H4B45_RS11275	COG2207	Transcriptional regulator
H4B45_RS11295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B45_RS11315	COG0183	Belongs to the thiolase family
H4B45_RS11325	COG2885	chlorophyll binding
H4B45_RS11325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4B45_RS11335	COG1690	Belongs to the RtcB family
H4B45_RS11340	COG0833	amino acid
H4B45_RS11350	COG2233	PERMEase
H4B45_RS11355	COG1217	gtp-binding protein TYPA
H4B45_RS11380	COG2094	Belongs to the DNA glycosylase MPG family
H4B45_RS11390	COG1902	pentaerythritol trinitrate reductase activity
H4B45_RS11405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B45_RS11410	COG0354	folic acid binding
H4B45_RS11420	COG3189	MarR family transcriptional regulator
H4B45_RS11425	COG2824	Alkylphosphonate utilization operon protein PhnA
H4B45_RS11430	COG3422	double-strand break repair
H4B45_RS11470	COG0840	transmembrane signaling receptor activity
H4B45_RS11490	COG5510	response to toxic substance
H4B45_RS11500	COG2832	Protein of unknown function (DUF454)
H4B45_RS11505	COG1376	ErfK ybiS ycfS ynhG family protein
H4B45_RS11545	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4B45_RS11555	COG1289	transmembrane transporter activity
H4B45_RS11560	COG2814	Major facilitator Superfamily
H4B45_RS11580	COG1115	amino acid carrier protein
H4B45_RS11585	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4B45_RS11590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4B45_RS11595	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H4B45_RS11620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4B45_RS11630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4B45_RS11635	COG1077	Cell shape determining protein MreB Mrl
H4B45_RS11640	COG1792	Involved in formation and maintenance of cell shape
H4B45_RS11645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4B45_RS11650	COG0424	maF-like protein
H4B45_RS11655	COG1530	ribonuclease E activity
H4B45_RS11665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B45_RS11675	COG0560	Phosphoserine phosphatase
H4B45_RS11685	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS11710	COG2207	Transcriptional regulator
H4B45_RS11745	COG2963	transposase activity
H4B45_RS11785	COG1214	PFAM Peptidase M22, glycoprotease
H4B45_RS11810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4B45_RS11815	COG0561	phosphatase activity
H4B45_RS11825	COG2132	Multicopper oxidase
H4B45_RS11845	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4B45_RS11850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4B45_RS11855	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4B45_RS11885	COG1063	alcohol dehydrogenase
H4B45_RS11890	COG0583	DNA-binding transcription factor activity
H4B45_RS11895	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS11900	COG2814	Major facilitator Superfamily
H4B45_RS11905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B45_RS11910	COG1309	transcriptional regulator
H4B45_RS11925	COG1053	succinate dehydrogenase
H4B45_RS11930	COG0583	DNA-binding transcription factor activity
H4B45_RS11945	COG0583	DNA-binding transcription factor activity
H4B45_RS11955	COG0583	DNA-binding transcription factor activity
H4B45_RS11970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS12020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4B45_RS12040	COG0745	RESPONSE REGULATOR receiver
H4B45_RS12055	COG3706	GGDEF domain
H4B45_RS12080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4B45_RS12110	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4B45_RS12115	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4B45_RS12140	COG0583	DNA-binding transcription factor activity
H4B45_RS12160	COG0668	transmembrane transport
H4B45_RS12170	COG2081	HI0933 family
H4B45_RS12175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H4B45_RS12205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B45_RS12205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B45_RS12215	COG0489	protein tyrosine kinase activity
H4B45_RS12265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4B45_RS12275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4B45_RS12290	COG0730	response to heat
H4B45_RS12300	COG1196	nuclear chromosome segregation
H4B45_RS12320	COG2223	nitrite transmembrane transporter activity
H4B45_RS12325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4B45_RS12330	COG1877	trehalose-phosphatase activity
H4B45_RS12335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B45_RS12335	COG2226	methyltransferase
H4B45_RS12335	COG0596	Alpha beta hydrolase
H4B45_RS12350	COG4106	trans-aconitate 2-methyltransferase activity
H4B45_RS12365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4B45_RS12370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4B45_RS12375	COG0009	L-threonylcarbamoyladenylate synthase
H4B45_RS12380	COG3101	peptidyl-lysine hydroxylation
H4B45_RS12385	COG1399	metal-binding, possibly nucleic acid-binding protein
H4B45_RS12410	COG1652	LysM domain
H4B45_RS12415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4B45_RS12415	COG0352	thiamine-phosphate diphosphorylase activity
H4B45_RS12415	COG0351	phosphomethylpyrimidine kinase
H4B45_RS12425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4B45_RS12455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4B45_RS12485	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H4B45_RS12500	COG0358	DNA primase activity
H4B45_RS12510	COG0564	pseudouridine synthase activity
H4B45_RS12535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B45_RS12555	COG0583	DNA-binding transcription factor activity
H4B45_RS12560	COG0473	3-isopropylmalate dehydrogenase activity
H4B45_RS12570	COG0657	acetylesterase activity
H4B45_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS12600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4B45_RS12600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4B45_RS12615	COG1981	membrane
H4B45_RS12665	COG4372	Transposase
H4B45_RS12675	COG0456	acetyltransferase
H4B45_RS12685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4B45_RS12690	COG0492	ferredoxin-NADP+ reductase activity
H4B45_RS12695	COG1674	ftsk spoiiie
H4B45_RS12695	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4B45_RS12700	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS12715	COG2894	cell division
H4B45_RS12730	COG0204	Acyl-transferase
H4B45_RS12735	COG2885	chlorophyll binding
H4B45_RS12740	COG0210	DNA helicase
H4B45_RS12750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4B45_RS12765	COG0121	glutamine amidotransferase
H4B45_RS12785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4B45_RS12790	COG0735	belongs to the Fur family
H4B45_RS12815	COG0420	3'-5' exonuclease activity
H4B45_RS12835	COG1090	epimerase
H4B45_RS12850	COG2050	protein possibly involved in aromatic compounds catabolism
H4B45_RS12860	COG2814	Major facilitator Superfamily
H4B45_RS12865	COG0405	Gamma-glutamyltransferase
H4B45_RS12875	COG0582	viral genome integration into host DNA
H4B45_RS12965	COG2963	transposase activity
H4B45_RS12970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
H4B45_RS12985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4B45_RS13020	COG0477	Major facilitator Superfamily
H4B45_RS13035	COG1595	DNA-templated transcription, initiation
H4B45_RS13090	COG0531	amino acid
H4B45_RS13095	COG2040	homocysteine
H4B45_RS13120	COG1309	transcriptional regulator
H4B45_RS13125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B45_RS13130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B45_RS13140	COG1607	acyl-coa hydrolase
H4B45_RS13150	COG0523	cobalamin synthesis protein
H4B45_RS13160	COG4681	YaeQ
H4B45_RS13170	COG1649	PFAM Uncharacterised BCR, COG1649
H4B45_RS13170	COG0726	polysaccharide deacetylase
H4B45_RS13175	COG1215	transferase activity, transferring glycosyl groups
H4B45_RS13185	COG1024	Enoyl-CoA hydratase
H4B45_RS13200	COG1414	Transcriptional regulator
H4B45_RS13220	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS13235	COG2271	Major facilitator Superfamily
H4B45_RS13245	COG2267	carboxylic ester hydrolase activity
H4B45_RS13250	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS13265	COG0028	Belongs to the TPP enzyme family
H4B45_RS13275	COG0477	Major facilitator Superfamily
H4B45_RS13280	COG0242	peptide deformylase activity
H4B45_RS13285	COG2066	Belongs to the glutaminase family
H4B45_RS13290	COG2207	Transcriptional regulator
H4B45_RS13295	COG2223	nitrite transmembrane transporter activity
H4B45_RS13310	COG0583	DNA-binding transcription factor activity
H4B45_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS13320	COG2271	Major facilitator Superfamily
H4B45_RS13325	COG3959	Transketolase, thiamine diphosphate binding domain
H4B45_RS13330	COG3958	Transketolase
H4B45_RS13340	COG0306	phosphate transporter
H4B45_RS13360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4B45_RS13405	COG4181	ATPase activity
H4B45_RS13410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4B45_RS13440	COG0583	DNA-binding transcription factor activity
H4B45_RS13450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B45_RS13455	COG1773	rubredoxin
H4B45_RS13505	COG2851	Citrate transporter
H4B45_RS13510	COG1253	flavin adenine dinucleotide binding
H4B45_RS13550	COG0804	urea catabolic process
H4B45_RS13560	COG0830	nickel cation binding
H4B45_RS13575	COG0742	ribosomal rna small subunit methyltransferase
H4B45_RS13580	COG0768	penicillin binding
H4B45_RS13605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4B45_RS13610	COG2878	Part of a membrane complex involved in electron transport
H4B45_RS13615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4B45_RS13625	COG3384	dioxygenase
H4B45_RS13650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4B45_RS13690	COG0006	proline dipeptidase activity
H4B45_RS13695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B45_RS13700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B45_RS13720	COG1279	arginine transmembrane transporter activity
H4B45_RS13730	COG2963	transposase activity
H4B45_RS13785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4B45_RS13790	COG1388	LysM domain
H4B45_RS13790	COG0741	lytic transglycosylase activity
H4B45_RS13790	COG1388	LysM domain
H4B45_RS13790	COG0741	lytic transglycosylase activity
H4B45_RS13800	COG4174	ABC transporter (Permease)
H4B45_RS13805	COG4239	(ABC) transporter, permease
H4B45_RS13810	COG4172	Belongs to the ABC transporter superfamily
H4B45_RS13830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4B45_RS13840	COG2203	Gaf domain
H4B45_RS13840	COG5001	Diguanylate cyclase
H4B45_RS13840	COG3706	GGDEF domain
H4B45_RS13840	COG4251	negative regulation of phosphorylation
H4B45_RS13850	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4B45_RS13850	COG1902	pentaerythritol trinitrate reductase activity
H4B45_RS13865	COG4269	membrane
H4B45_RS13910	COG1113	amino acid transport
H4B45_RS13920	COG0531	amino acid
H4B45_RS13940	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS13960	COG1113	amino acid transport
H4B45_RS13975	COG0697	spore germination
H4B45_RS13980	COG2721	sulfolactate sulfo-lyase activity
H4B45_RS13985	COG2271	Major facilitator Superfamily
H4B45_RS13990	COG4948	Mandelate Racemase Muconate Lactonizing
H4B45_RS14000	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS14005	COG2186	Transcriptional regulator
H4B45_RS14030	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS14040	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS14045	COG1024	Enoyl-CoA hydratase
H4B45_RS14050	COG2814	Major facilitator Superfamily
H4B45_RS14065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B45_RS14080	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4B45_RS14130	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H4B45_RS14135	COG2072	flavoprotein involved in K transport
H4B45_RS14140	COG0300	oxidoreductase activity
H4B45_RS14150	COG1309	transcriptional regulator
H4B45_RS14155	COG1741	Belongs to the pirin family
H4B45_RS14170	COG2072	flavoprotein involved in K transport
H4B45_RS14180	COG2252	PERMEase
H4B45_RS14185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4B45_RS14190	COG3038	cytochrome b561
H4B45_RS14200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4B45_RS14210	COG0527	aspartate kinase activity
H4B45_RS14220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4B45_RS14235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4B45_RS14255	COG0667	Aldo Keto reductase
H4B45_RS14270	COG1765	OsmC-like protein
H4B45_RS14285	COG0542	response to heat
H4B45_RS14320	COG2885	chlorophyll binding
H4B45_RS14330	COG0625	glutathione transferase activity
H4B45_RS14335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4B45_RS14355	COG3634	alkyl hydroperoxide reductase activity
H4B45_RS14365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4B45_RS14375	COG0450	alkyl hydroperoxide reductase
H4B45_RS14380	COG1643	Atp-dependent helicase
H4B45_RS14395	COG2814	Major facilitator Superfamily
H4B45_RS14400	COG3135	benzoate transporter
H4B45_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS14410	COG0633	Ferredoxin
H4B45_RS14410	COG0543	2 iron, 2 sulfur cluster binding
H4B45_RS14415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4B45_RS14420	COG4638	Rieske (2fe-2S)
H4B45_RS14425	COG0583	DNA-binding transcription factor activity
H4B45_RS14475	COG1570	exodeoxyribonuclease VII activity
H4B45_RS14505	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS14510	COG1278	Cold shock
H4B45_RS14545	COG2814	Major facilitator Superfamily
H4B45_RS14585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4B45_RS14595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4B45_RS14600	COG1137	ATPase activity
H4B45_RS14605	COG1538	Outer membrane efflux protein
H4B45_RS14645	COG4122	O-methyltransferase activity
H4B45_RS14655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4B45_RS14670	COG1522	sequence-specific DNA binding
H4B45_RS14685	COG1560	Kdo2-lipid A biosynthetic process
H4B45_RS14695	COG2814	Major facilitator Superfamily
H4B45_RS14715	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B45_RS14755	COG0583	DNA-binding transcription factor activity
H4B45_RS14760	COG1914	H( )-stimulated, divalent metal cation uptake system
H4B45_RS14780	COG4770	biotin carboxylase activity
H4B45_RS14785	COG0038	chloride channel
H4B45_RS14790	COG2831	hemolysin activation secretion protein
H4B45_RS14795	COG3210	domain, Protein
H4B45_RS14820	COG1063	alcohol dehydrogenase
H4B45_RS14835	COG0439	Biotin carboxylase
H4B45_RS14840	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B45_RS14845	COG1733	regulation of RNA biosynthetic process
H4B45_RS14860	COG0864	Transcriptional regulator
H4B45_RS14870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B45_RS14875	COG1116	anion transmembrane transporter activity
H4B45_RS15000	COG0590	tRNA wobble adenosine to inosine editing
H4B45_RS15005	COG2807	transmembrane transport
H4B45_RS15020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4B45_RS15030	COG0789	Transcriptional regulator
H4B45_RS15040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B45_RS15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4B45_RS15085	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS15090	COG0531	amino acid
H4B45_RS15095	COG1760	l-serine dehydratase
H4B45_RS15100	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS15100	COG2030	dehydratase
H4B45_RS15105	COG3396	Phenylacetate-CoA oxygenase
H4B45_RS15110	COG3460	Phenylacetate-CoA oxygenase
H4B45_RS15115	COG3396	Phenylacetate-CoA oxygenase
H4B45_RS15120	COG2151	metal-sulfur cluster biosynthetic enzyme
H4B45_RS15125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B45_RS15130	COG1024	Enoyl-CoA hydratase
H4B45_RS15135	COG1024	Enoyl-CoA hydratase
H4B45_RS15140	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B45_RS15145	COG0183	Belongs to the thiolase family
H4B45_RS15150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H4B45_RS15155	COG3327	negative regulation of DNA-templated transcription, initiation
H4B45_RS15165	COG2050	protein possibly involved in aromatic compounds catabolism
H4B45_RS15195	COG0753	catalase activity
H4B45_RS15200	COG3038	cytochrome b561
H4B45_RS15220	COG2267	carboxylic ester hydrolase activity
H4B45_RS15225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS15230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B45_RS15245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4B45_RS15255	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS15260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4B45_RS15265	COG0583	DNA-binding transcription factor activity
H4B45_RS15275	COG1414	Transcriptional regulator
H4B45_RS15280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B45_RS15290	COG1840	ABC-type Fe3 transport system, periplasmic component
H4B45_RS15295	COG3842	ATPase activity
H4B45_RS15310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4B45_RS15315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4B45_RS15320	COG2814	Major facilitator Superfamily
H4B45_RS15325	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS15330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B45_RS15340	COG1024	Enoyl-CoA hydratase
H4B45_RS15350	COG2814	Major facilitator Superfamily
H4B45_RS15360	COG0183	Belongs to the thiolase family
H4B45_RS15365	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B45_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS15375	COG1024	Enoyl-CoA hydratase
H4B45_RS15380	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS15385	COG2814	Major facilitator Superfamily
H4B45_RS15390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B45_RS15395	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4B45_RS15405	COG2814	Major facilitator Superfamily
H4B45_RS15415	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS15430	COG0583	DNA-binding transcription factor activity
H4B45_RS15440	COG4770	biotin carboxylase activity
H4B45_RS15445	COG1024	Enoyl-CoA hydratase
H4B45_RS15450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4B45_RS15455	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS15460	COG1309	transcriptional regulator
H4B45_RS15465	COG0318	PFAM AMP-dependent synthetase and ligase
H4B45_RS15485	COG0583	DNA-binding transcription factor activity
H4B45_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS15555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4B45_RS15575	COG0784	Response regulator, receiver
H4B45_RS15575	COG2205	protein histidine kinase activity
H4B45_RS15595	COG0765	amino acid transport
H4B45_RS15600	COG0765	amino acid transport
H4B45_RS15605	COG1126	abc transporter atp-binding protein
H4B45_RS15610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B45_RS15615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B45_RS15630	COG1280	lysine exporter protein (LysE YggA)
H4B45_RS15635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4B45_RS15640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4B45_RS15645	COG1045	serine acetyltransferase
H4B45_RS15660	COG0583	DNA-binding transcription factor activity
H4B45_RS15665	COG0625	glutathione transferase activity
H4B45_RS15670	COG0625	glutathione transferase activity
H4B45_RS15675	COG0583	DNA-binding transcription factor activity
H4B45_RS15685	COG1346	cytolysis
H4B45_RS15705	COG2814	Major facilitator Superfamily
H4B45_RS15715	COG0583	DNA-binding transcription factor activity
H4B45_RS15725	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H4B45_RS15730	COG3052	prosthetic group binding
H4B45_RS15750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4B45_RS15770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B45_RS15780	COG1294	oxidase, subunit
H4B45_RS15785	COG1271	oxidase subunit
H4B45_RS15805	COG0477	Major facilitator Superfamily
H4B45_RS15815	COG4521	taurine ABC transporter
H4B45_RS15820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4B45_RS15825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4B45_RS15830	COG2175	clavaminate synthase activity
H4B45_RS15840	COG1953	Uracil, thiamine, allantoin
H4B45_RS15850	COG0583	DNA-binding transcription factor activity
H4B45_RS15860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4B45_RS15875	COG0640	Transcriptional regulator
H4B45_RS15880	COG0798	PFAM Bile acid sodium symporter
H4B45_RS15885	COG0583	DNA-binding transcription factor activity
H4B45_RS15900	COG3634	alkyl hydroperoxide reductase activity
H4B45_RS15940	COG0436	Aminotransferase
H4B45_RS15950	COG0386	Belongs to the glutathione peroxidase family
H4B45_RS15990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4B45_RS16015	COG0012	GTP binding
H4B45_RS16020	COG2011	ABC-type metal ion transport system permease component
H4B45_RS16025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4B45_RS16035	COG1464	Belongs to the NlpA lipoprotein family
H4B45_RS16065	COG0765	amino acid transport
H4B45_RS16070	COG0765	amino acid transport
H4B45_RS16075	COG1126	abc transporter atp-binding protein
H4B45_RS16085	COG1522	sequence-specific DNA binding
H4B45_RS16100	COG1309	transcriptional regulator
H4B45_RS16120	COG0583	DNA-binding transcription factor activity
H4B45_RS16130	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4B45_RS16140	COG0697	spore germination
H4B45_RS16165	COG3121	Chaperone
H4B45_RS16170	COG3539	Fimbrial protein
H4B45_RS16195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4B45_RS16195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4B45_RS16240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4B45_RS16250	COG2353	YceI-like domain
H4B45_RS16260	COG3698	Phosphodiester glycosidase
H4B45_RS16275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H4B45_RS16280	COG0506	proline dehydrogenase activity
H4B45_RS16280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4B45_RS16280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4B45_RS16290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4B45_RS16295	COG2963	transposase activity
H4B45_RS16310	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4B45_RS16330	COG1132	(ABC) transporter
H4B45_RS16335	COG3122	Protein conserved in bacteria
H4B45_RS16340	COG3619	membrane
H4B45_RS16350	COG0640	Transcriptional regulator
H4B45_RS16360	COG2850	peptidyl-arginine hydroxylation
H4B45_RS16365	COG0424	maF-like protein
H4B45_RS16385	COG0191	fructose-bisphosphate aldolase activity
H4B45_RS16390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4B45_RS16405	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4B45_RS16415	COG1192	Involved in chromosome partitioning
H4B45_RS16420	COG1475	DNA binding
H4B45_RS16425	COG0811	peptide transport
H4B45_RS16435	COG1132	(ABC) transporter
H4B45_RS16440	COG1663	tetraacyldisaccharide 4'-kinase activity
H4B45_RS16460	COG0084	hydrolase, TatD family'
H4B45_RS16525	COG0776	regulation of translation
H4B45_RS16555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4B45_RS16560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4B45_RS16610	COG0339	signal peptide processing
H4B45_RS16620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4B45_RS16655	COG0702	epimerase
H4B45_RS16660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4B45_RS16680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4B45_RS16710	COG0316	Belongs to the HesB IscA family
H4B45_RS16715	COG0822	iron-sulfur transferase activity
H4B45_RS16740	COG0776	regulation of translation
H4B45_RS16745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4B45_RS16750	COG2207	Transcriptional regulator
H4B45_RS16755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4B45_RS16760	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS16765	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS16780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4B45_RS16800	COG4264	IucA IucC family
H4B45_RS16805	COG4264	IucA IucC family
H4B45_RS16815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4B45_RS16845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4B45_RS16860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4B45_RS16880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4B45_RS16885	COG0730	response to heat
H4B45_RS16905	COG4773	Receptor
H4B45_RS16910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B45_RS16925	COG1131	(ABC) transporter
H4B45_RS16930	COG0842	Transport permease protein
H4B45_RS16935	COG0842	Transport permease protein
H4B45_RS16990	COG2226	methyltransferase
H4B45_RS17015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4B45_RS17050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4B45_RS17060	COG0133	tryptophan synthase activity
H4B45_RS17075	COG3706	GGDEF domain
H4B45_RS17090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4B45_RS17095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4B45_RS17100	COG0022	dehydrogenase e1 component
H4B45_RS17105	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4B45_RS17110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B45_RS17120	COG1063	alcohol dehydrogenase
H4B45_RS17125	COG3781	membrane
H4B45_RS17135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B45_RS17135	COG3453	Protein conserved in bacteria
H4B45_RS17145	COG0730	response to heat
H4B45_RS17160	COG2207	Transcriptional regulator
H4B45_RS17160	COG3708	Transcriptional regulator
H4B45_RS17165	COG1733	regulation of RNA biosynthetic process
H4B45_RS17170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4B45_RS17180	COG2188	Transcriptional regulator
H4B45_RS17195	COG4521	taurine ABC transporter
H4B45_RS17220	COG0477	Major facilitator Superfamily
H4B45_RS17230	COG1027	Aspartate ammonia-lyase
H4B45_RS17245	COG0583	DNA-binding transcription factor activity
H4B45_RS17250	COG0583	DNA-binding transcription factor activity
H4B45_RS17255	COG0183	Belongs to the thiolase family
H4B45_RS17260	COG2031	fatty acid transporter
H4B45_RS17275	COG0583	DNA-binding transcription factor activity
H4B45_RS17290	COG1309	transcriptional regulator
H4B45_RS17300	COG2610	gluconate transmembrane transporter activity
H4B45_RS17305	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS17310	COG2207	Transcriptional regulator
H4B45_RS17325	COG2963	transposase activity
H4B45_RS17345	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS17355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS17370	COG0543	2 iron, 2 sulfur cluster binding
H4B45_RS17370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B45_RS17375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4B45_RS17380	COG4638	Rieske (2fe-2S)
H4B45_RS17390	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4B45_RS17395	COG4149	molybdate abc transporter
H4B45_RS17400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4B45_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS17410	COG1535	isochorismatase
H4B45_RS17410	COG3433	isochorismatase activity
H4B45_RS17475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4B45_RS17490	COG0753	catalase activity
H4B45_RS17500	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H4B45_RS17525	COG3539	Fimbrial protein
H4B45_RS17540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4B45_RS17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B45_RS17550	COG0745	RESPONSE REGULATOR receiver
H4B45_RS17555	COG2205	protein histidine kinase activity
H4B45_RS17565	COG2207	Transcriptional regulator
H4B45_RS17580	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS17585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B45_RS17590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4B45_RS17595	COG2851	Citrate transporter
H4B45_RS17600	COG1414	Transcriptional regulator
H4B45_RS17620	COG0583	DNA-binding transcription factor activity
H4B45_RS17715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4B45_RS17765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4B45_RS17785	COG1120	ATPase activity
H4B45_RS17790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4B45_RS17800	COG1064	alcohol dehydrogenase
H4B45_RS17815	COG2207	Transcriptional regulator
H4B45_RS17820	COG2084	Dehydrogenase
H4B45_RS17830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4B45_RS17835	COG0583	DNA-binding transcription factor activity
H4B45_RS17845	COG0129	dihydroxy-acid dehydratase activity
H4B45_RS17850	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS17870	COG1566	PFAM secretion protein HlyD family protein
H4B45_RS17895	COG0583	DNA-binding transcription factor activity
H4B45_RS17910	COG2188	Transcriptional regulator
H4B45_RS17945	COG4191	Histidine kinase
H4B45_RS17960	COG1473	amidohydrolase
H4B45_RS17970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B45_RS17970	COG0475	glutathione-regulated potassium exporter activity
H4B45_RS17980	COG0583	DNA-binding transcription factor activity
H4B45_RS17985	COG1335	isochorismatase
H4B45_RS17995	COG1309	transcriptional regulator
H4B45_RS18035	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4B45_RS18035	COG1902	pentaerythritol trinitrate reductase activity
H4B45_RS18050	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS18070	COG2186	Transcriptional regulator
H4B45_RS18080	COG0583	DNA-binding transcription factor activity
H4B45_RS18085	COG4948	Mandelate Racemase Muconate Lactonizing
H4B45_RS18090	COG4829	muconolactone delta-isomerase
H4B45_RS18100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B45_RS18105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4B45_RS18110	COG0183	Belongs to the thiolase family
H4B45_RS18115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B45_RS18125	COG1012	belongs to the aldehyde dehydrogenase family
H4B45_RS18135	COG3733	amine oxidase
H4B45_RS18145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B45_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
H4B45_RS18165	COG4638	Rieske (2fe-2S)
H4B45_RS18185	COG0154	amidase activity
H4B45_RS18195	COG2814	Major facilitator Superfamily
H4B45_RS18220	COG1960	acyl-CoA dehydrogenase activity
H4B45_RS18225	COG0583	DNA-binding transcription factor activity
H4B45_RS18230	COG1414	Transcriptional regulator
H4B45_RS18245	COG2391	methyltransferase activity
H4B45_RS18255	COG4993	Dehydrogenase
H4B45_RS18260	COG3659	wide pore channel activity
H4B45_RS18265	COG3420	alginic acid biosynthetic process
H4B45_RS18270	COG0710	3-dehydroquinate dehydratase activity
H4B45_RS18275	COG3485	protocatechuate 3,4-dioxygenase
H4B45_RS18280	COG3485	protocatechuate 3,4-dioxygenase
H4B45_RS18285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4B45_RS18290	COG2271	Major facilitator Superfamily
H4B45_RS18295	COG0596	Alpha beta hydrolase
H4B45_RS18300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4B45_RS18305	COG0183	Belongs to the thiolase family
H4B45_RS18310	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit