locus-tag	class	description
H4B46_RS00175	COG0512	Glutamine amidotransferase of anthranilate synthase
H4B46_RS00180	COG0308	aminopeptidase N
H4B46_RS00210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4B46_RS00220	COG0302	gtp cyclohydrolase
H4B46_RS00245	COG3739	integral membrane protein
H4B46_RS00265	COG2977	Belongs to the P-Pant transferase superfamily
H4B46_RS00270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H4B46_RS00275	COG1132	(ABC) transporter
H4B46_RS00280	COG1132	(ABC) transporter
H4B46_RS00290	COG1535	isochorismatase
H4B46_RS00290	COG3433	isochorismatase activity
H4B46_RS00295	COG1021	2,3-dihydroxybenzoate-AMP ligase
H4B46_RS00300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B46_RS00310	COG4774	siderophore transport
H4B46_RS00315	COG4607	ABC-type enterochelin transport system periplasmic component
H4B46_RS00320	COG4604	ABC transporter, ATP-binding protein
H4B46_RS00325	COG4605	iron ion homeostasis
H4B46_RS00330	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4B46_RS00335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B46_RS00350	COG2964	Protein conserved in bacteria
H4B46_RS00360	COG1741	Belongs to the pirin family
H4B46_RS00380	COG1309	transcriptional regulator
H4B46_RS00400	COG2963	transposase activity
H4B46_RS00420	COG2963	transposase activity
H4B46_RS00425	COG4948	Mandelate Racemase Muconate Lactonizing
H4B46_RS00430	COG2814	Major facilitator Superfamily
H4B46_RS00465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4B46_RS00465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4B46_RS00470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B46_RS00475	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS00490	COG0477	Major facilitator Superfamily
H4B46_RS00495	COG0006	proline dipeptidase activity
H4B46_RS00500	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS00505	COG0583	DNA-binding transcription factor activity
H4B46_RS00515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4B46_RS00525	COG0596	Alpha beta hydrolase
H4B46_RS00540	COG0583	DNA-binding transcription factor activity
H4B46_RS00545	COG1335	isochorismatase
H4B46_RS00585	COG2879	small protein
H4B46_RS00590	COG1966	Carbon starvation protein
H4B46_RS00610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4B46_RS00635	COG1067	ATP-dependent peptidase activity
H4B46_RS00640	COG0583	DNA-binding transcription factor activity
H4B46_RS00665	COG1686	Belongs to the peptidase S11 family
H4B46_RS00670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4B46_RS00705	COG0616	signal peptide processing
H4B46_RS00710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4B46_RS00720	COG0573	inorganic phosphate transmembrane transporter activity
H4B46_RS00725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4B46_RS00730	COG1113	amino acid transport
H4B46_RS00735	COG3961	Belongs to the TPP enzyme family
H4B46_RS00740	COG1522	sequence-specific DNA binding
H4B46_RS00750	COG0076	glutamate decarboxylase activity
H4B46_RS00755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4B46_RS00770	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS00780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B46_RS00815	COG0352	thiamine-phosphate diphosphorylase activity
H4B46_RS00840	COG0612	Peptidase, M16
H4B46_RS00850	COG1823	symporter activity
H4B46_RS00855	COG0583	DNA-binding transcription factor activity
H4B46_RS00860	COG0477	Major facilitator Superfamily
H4B46_RS00890	COG1187	pseudouridine synthase activity
H4B46_RS00905	COG1686	Belongs to the peptidase S11 family
H4B46_RS00910	COG1252	NADH dehydrogenase
H4B46_RS00920	COG0415	Belongs to the DNA photolyase family
H4B46_RS00935	COG1215	transferase activity, transferring glycosyl groups
H4B46_RS00965	COG2070	2-Nitropropane dioxygenase
H4B46_RS01020	COG0556	nucleotide-excision repair
H4B46_RS01040	COG0436	Aminotransferase
H4B46_RS01050	COG0443	Heat shock 70 kDa protein
H4B46_RS01080	COG4221	oxidoreductase activity
H4B46_RS01090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H4B46_RS01095	COG1381	Involved in DNA repair and RecF pathway recombination
H4B46_RS01105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4B46_RS01120	COG0681	Belongs to the peptidase S26 family
H4B46_RS01135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4B46_RS01155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4B46_RS01160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4B46_RS01165	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4B46_RS01175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4B46_RS01180	COG4208	sulfate ABC transporter
H4B46_RS01185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4B46_RS01190	COG0583	DNA-binding transcription factor activity
H4B46_RS01195	COG4625	pathogenesis
H4B46_RS01210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4B46_RS01225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4B46_RS01235	COG1056	cytidyltransferase-related domain
H4B46_RS01235	COG1051	belongs to the nudix hydrolase family
H4B46_RS01240	COG1024	Enoyl-CoA hydratase
H4B46_RS01250	COG2814	Major facilitator Superfamily
H4B46_RS01255	COG0047	phosphoribosylformylglycinamidine synthase activity
H4B46_RS01255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4B46_RS01275	COG1473	amidohydrolase
H4B46_RS01280	COG0824	Thioesterase
H4B46_RS01300	COG0823	Involved in the tonB-independent uptake of proteins
H4B46_RS01320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4B46_RS01340	COG2963	transposase activity
H4B46_RS01370	COG0628	permease
H4B46_RS01380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4B46_RS01385	COG0596	Alpha beta hydrolase
H4B46_RS01390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4B46_RS01390	COG0616	signal peptide processing
H4B46_RS01400	COG0658	competence protein
H4B46_RS01400	COG2333	competence protein COMEC
H4B46_RS01405	COG1136	(ABC) transporter
H4B46_RS01410	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4B46_RS01450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS01470	COG0463	Glycosyl transferase, family 2
H4B46_RS01500	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H4B46_RS01505	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS01515	COG0019	diaminopimelate decarboxylase activity
H4B46_RS01525	COG1113	amino acid transport
H4B46_RS01540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4B46_RS01550	COG3339	Conserved Protein
H4B46_RS01555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4B46_RS01560	COG0243	molybdopterin cofactor binding
H4B46_RS01565	COG1929	Belongs to the glycerate kinase type-1 family
H4B46_RS01580	COG0778	Nitroreductase
H4B46_RS01600	COG3811	Belongs to the UPF0386 family
H4B46_RS01625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4B46_RS01645	COG0741	lytic transglycosylase activity
H4B46_RS01665	COG0584	glycerophosphoryl diester phosphodiesterase
H4B46_RS01670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B46_RS01700	COG1597	lipid kinase activity
H4B46_RS01715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H4B46_RS01720	COG0477	Major facilitator Superfamily
H4B46_RS01770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4B46_RS01775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4B46_RS01800	COG0505	Belongs to the CarA family
H4B46_RS01820	COG0589	response to stress
H4B46_RS01835	COG2843	Capsule synthesis protein
H4B46_RS01870	COG2321	neutral zinc metallopeptidase
H4B46_RS01875	COG2354	Protein conserved in bacteria
H4B46_RS01895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B46_RS01920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4B46_RS01925	COG1053	succinate dehydrogenase
H4B46_RS01930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4B46_RS01935	COG2009	succinate dehydrogenase
H4B46_RS01975	COG2921	Belongs to the UPF0250 family
H4B46_RS01980	COG0321	lipoyl(octanoyl) transferase activity
H4B46_RS01995	COG0531	amino acid
H4B46_RS02005	COG1733	regulation of RNA biosynthetic process
H4B46_RS02010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4B46_RS02015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H4B46_RS02015	COG1648	precorrin-2 dehydrogenase activity
H4B46_RS02030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H4B46_RS02060	COG0671	phosphoesterase, PA-phosphatase related
H4B46_RS02065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS02075	COG1538	Outer membrane efflux protein
H4B46_RS02095	COG0393	Putative heavy-metal-binding
H4B46_RS02100	COG0393	Putative heavy-metal-binding
H4B46_RS02110	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS02120	COG0525	valine-tRNA ligase activity
H4B46_RS02125	COG2226	methyltransferase
H4B46_RS02140	COG0583	DNA-binding transcription factor activity
H4B46_RS02145	COG0004	ammonium transporteR
H4B46_RS02155	COG0642	Histidine kinase
H4B46_RS02160	COG0745	RESPONSE REGULATOR receiver
H4B46_RS02165	COG2194	sulfuric ester hydrolase activity
H4B46_RS02175	COG2963	transposase activity
H4B46_RS02200	COG2963	transposase activity
H4B46_RS02215	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4B46_RS02230	COG2315	Protein conserved in bacteria
H4B46_RS02235	COG0142	geranyltranstransferase activity
H4B46_RS02240	COG2828	Protein conserved in bacteria
H4B46_RS02245	COG1113	amino acid transport
H4B46_RS02265	COG2963	transposase activity
H4B46_RS02305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4B46_RS02310	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4B46_RS02315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4B46_RS02375	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4B46_RS02385	COG1846	Transcriptional regulator
H4B46_RS02390	COG1764	response to oxidative stress
H4B46_RS02430	COG0037	tRNA processing
H4B46_RS02440	COG0248	Ppx GppA phosphatase
H4B46_RS02470	COG0072	phenylalanine-tRNA ligase activity
H4B46_RS02510	COG1238	metal cluster binding
H4B46_RS02515	COG0625	glutathione transferase activity
H4B46_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
H4B46_RS02535	COG3028	Belongs to the UPF0307 family
H4B46_RS02540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4B46_RS02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4B46_RS02565	COG0617	tRNA 3'-terminal CCA addition
H4B46_RS02570	COG1555	photosystem II stabilization
H4B46_RS02575	COG3956	TIGRFAM MazG family protein
H4B46_RS02585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4B46_RS02605	COG5002	protein histidine kinase activity
H4B46_RS02605	COG0784	Response regulator, receiver
H4B46_RS02605	COG2205	protein histidine kinase activity
H4B46_RS02610	COG1024	Enoyl-CoA hydratase
H4B46_RS02615	COG2084	Dehydrogenase
H4B46_RS02620	COG3622	Belongs to the hyi family
H4B46_RS02650	COG0697	spore germination
H4B46_RS02660	COG2814	Major facilitator Superfamily
H4B46_RS02665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4B46_RS02675	COG0583	DNA-binding transcription factor activity
H4B46_RS02685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4B46_RS02695	COG0084	hydrolase, TatD family'
H4B46_RS02710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4B46_RS02750	COG0440	acetolactate synthase activity
H4B46_RS02755	COG0028	Belongs to the TPP enzyme family
H4B46_RS02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS02785	COG1136	(ABC) transporter
H4B46_RS02785	COG0577	efflux transmembrane transporter activity
H4B46_RS02790	COG1538	Outer membrane efflux protein
H4B46_RS02805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4B46_RS02810	COG1162	GTPase activity
H4B46_RS02820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H4B46_RS02860	COG1426	Protein conserved in bacteria
H4B46_RS02895	COG0793	Belongs to the peptidase S41A family
H4B46_RS02910	COG2267	carboxylic ester hydrolase activity
H4B46_RS02920	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS02925	COG3265	gluconokinase activity
H4B46_RS02935	COG0800	Aldolase
H4B46_RS02945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4B46_RS02950	COG0280	phosphate acetyltransferase
H4B46_RS02950	COG0857	belongs to the CobB CobQ family
H4B46_RS02955	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H4B46_RS02955	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H4B46_RS02975	COG0740	serine-type endopeptidase activity
H4B46_RS02985	COG4774	siderophore transport
H4B46_RS02995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4B46_RS03005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B46_RS03005	COG2813	Specifically methylates the guanine in position
H4B46_RS03105	COG0788	formyltetrahydrofolate deformylase activity
H4B46_RS03130	COG4651	solute:proton antiporter activity
H4B46_RS03130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B46_RS03150	COG0724	RNA recognition motif
H4B46_RS03155	COG0210	DNA helicase
H4B46_RS03180	COG1733	regulation of RNA biosynthetic process
H4B46_RS03190	COG2900	Belongs to the SlyX family
H4B46_RS03195	COG0488	(ABC) transporter
H4B46_RS03200	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS03205	COG1560	Kdo2-lipid A biosynthetic process
H4B46_RS03215	COG1301	dicarboxylic acid transport
H4B46_RS03270	COG0473	3-isopropylmalate dehydrogenase activity
H4B46_RS03335	COG0583	DNA-binding transcription factor activity
H4B46_RS03345	COG0625	glutathione transferase activity
H4B46_RS03350	COG2378	regulation of single-species biofilm formation
H4B46_RS03355	COG0546	phosphoglycolate phosphatase activity
H4B46_RS03365	COG1530	ribonuclease E activity
H4B46_RS03370	COG0318	PFAM AMP-dependent synthetase and ligase
H4B46_RS03385	COG0583	DNA-binding transcription factor activity
H4B46_RS03390	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS03395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4B46_RS03405	COG0534	Mate efflux family protein
H4B46_RS03410	COG2963	transposase activity
H4B46_RS03435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H4B46_RS03465	COG0493	'glutamate synthase
H4B46_RS03465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B46_RS03475	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H4B46_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B46_RS03495	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4B46_RS03505	COG0644	oxidoreductase
H4B46_RS03505	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H4B46_RS03515	COG0425	Belongs to the sulfur carrier protein TusA family
H4B46_RS03520	COG4535	Mg2 and Co2 transporter CorC
H4B46_RS03530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B46_RS03550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4B46_RS03555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B46_RS03555	COG0475	glutathione-regulated potassium exporter activity
H4B46_RS03570	COG0484	heat shock protein binding
H4B46_RS03575	COG0789	Transcriptional regulator
H4B46_RS03580	COG0598	Magnesium transport protein CorA
H4B46_RS03595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4B46_RS03600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4B46_RS03605	COG1074	ATP-dependent DNA helicase activity
H4B46_RS03610	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4B46_RS03630	COG2226	methyltransferase
H4B46_RS03645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B46_RS03650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4B46_RS03665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4B46_RS03665	COG2111	Na H antiporter
H4B46_RS03670	COG1006	Multisubunit Na H antiporter MnhC subunit
H4B46_RS03675	COG0651	ATP synthesis coupled electron transport
H4B46_RS03680	COG1863	multisubunit Na H antiporter MnhE subunit
H4B46_RS03685	COG2212	antiporter activity
H4B46_RS03690	COG1320	monovalent cation:proton antiporter activity
H4B46_RS03705	COG0195	Participates in both transcription termination and antitermination
H4B46_RS03755	COG0237	dephospho-CoA kinase activity
H4B46_RS03765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4B46_RS03780	COG0497	DNA recombination
H4B46_RS03790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4B46_RS03820	COG2169	Transcriptional regulator
H4B46_RS03820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4B46_RS03825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H4B46_RS03875	COG0789	Transcriptional regulator
H4B46_RS03885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H4B46_RS03900	COG0326	Molecular chaperone. Has ATPase activity
H4B46_RS03915	COG2056	Na+-H+ antiporter family
H4B46_RS04015	COG0546	phosphoglycolate phosphatase activity
H4B46_RS04020	COG1716	ATPase activity
H4B46_RS04075	COG0181	hydroxymethylbilane synthase activity
H4B46_RS04085	COG3275	phosphorelay sensor kinase activity
H4B46_RS04105	COG1538	Outer membrane efflux protein
H4B46_RS04110	COG0697	spore germination
H4B46_RS04135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H4B46_RS04140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4B46_RS04145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4B46_RS04150	COG0772	Belongs to the SEDS family
H4B46_RS04175	COG4974	Belongs to the 'phage' integrase family
H4B46_RS04180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B46_RS04190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4B46_RS04200	COG2197	response regulator
H4B46_RS04215	COG0793	Belongs to the peptidase S41A family
H4B46_RS04220	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H4B46_RS04225	COG0795	lipopolysaccharide-transporting ATPase activity
H4B46_RS04265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4B46_RS04265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4B46_RS04275	COG0004	ammonium transporteR
H4B46_RS04280	COG0347	Belongs to the P(II) protein family
H4B46_RS04290	COG0606	chelatase, subunit chli
H4B46_RS04360	COG2132	Multicopper oxidase
H4B46_RS04375	COG2205	protein histidine kinase activity
H4B46_RS04380	COG2217	Heavy metal translocating P-type atpase
H4B46_RS04395	COG2963	transposase activity
H4B46_RS04435	COG0606	chelatase, subunit chli
H4B46_RS04440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B46_RS04445	COG0235	Class ii aldolase
H4B46_RS04450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B46_RS04475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4B46_RS04490	COG0318	PFAM AMP-dependent synthetase and ligase
H4B46_RS04500	COG0477	Major facilitator Superfamily
H4B46_RS04505	COG2860	membrane
H4B46_RS04510	COG3012	SEC-C Motif Domain Protein
H4B46_RS04515	COG1253	flavin adenine dinucleotide binding
H4B46_RS04525	COG0477	Major facilitator Superfamily
H4B46_RS04535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4B46_RS04570	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS04580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4B46_RS04615	COG1309	transcriptional regulator
H4B46_RS04650	COG0758	DNA mediated transformation
H4B46_RS04660	COG0697	spore germination
H4B46_RS04665	COG1309	transcriptional regulator
H4B46_RS04680	COG0386	Belongs to the glutathione peroxidase family
H4B46_RS04750	COG1121	(ABC) transporter
H4B46_RS04755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4B46_RS04760	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS04765	COG2837	iron assimilation
H4B46_RS04775	COG0281	malic enzyme
H4B46_RS04820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4B46_RS04820	COG0519	Catalyzes the synthesis of GMP from XMP
H4B46_RS04825	COG4399	Belongs to the UPF0754 family
H4B46_RS04830	COG2259	Doxx family
H4B46_RS04835	COG0586	Pfam SNARE associated Golgi protein
H4B46_RS04850	COG1192	Involved in chromosome partitioning
H4B46_RS04860	COG0271	Belongs to the BolA IbaG family
H4B46_RS04900	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H4B46_RS04900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4B46_RS04900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4B46_RS04900	COG3321	synthase
H4B46_RS04905	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS04915	COG2197	response regulator
H4B46_RS04925	COG3916	Acyl-homoserine-lactone synthase
H4B46_RS04930	COG0477	Major facilitator Superfamily
H4B46_RS04935	COG1024	Enoyl-CoA hydratase
H4B46_RS04940	COG1024	Enoyl-CoA hydratase
H4B46_RS04945	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS04950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B46_RS04970	COG1113	amino acid transport
H4B46_RS04975	COG1113	amino acid transport
H4B46_RS04980	COG0251	oxidation-reduction process
H4B46_RS05020	COG0564	pseudouridine synthase activity
H4B46_RS05090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H4B46_RS05105	COG1802	Transcriptional regulator
H4B46_RS05115	COG1448	Aminotransferase
H4B46_RS05120	COG0277	FAD linked oxidase domain protein
H4B46_RS05130	COG2186	Transcriptional regulator
H4B46_RS05140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4B46_RS05145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4B46_RS05160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4B46_RS05165	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4B46_RS05170	COG1216	Glycosyl transferase, family 2
H4B46_RS05195	COG0438	transferase activity, transferring glycosyl groups
H4B46_RS05230	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4B46_RS05260	COG0728	peptidoglycan biosynthetic process
H4B46_RS05265	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4B46_RS05340	COG1126	abc transporter atp-binding protein
H4B46_RS05360	COG2188	Transcriptional regulator
H4B46_RS05370	COG0523	cobalamin synthesis protein
H4B46_RS05380	COG1113	amino acid transport
H4B46_RS05390	COG0625	glutathione transferase activity
H4B46_RS05410	COG1683	Conserved Protein
H4B46_RS05420	COG0385	Bile acid
H4B46_RS05425	COG1335	isochorismatase
H4B46_RS05430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B46_RS05450	COG2116	formate transmembrane transporter activity
H4B46_RS05455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4B46_RS05460	COG2133	pyrroloquinoline quinone binding
H4B46_RS05465	COG2983	Belongs to the UPF0260 family
H4B46_RS05485	COG1194	a g-specific adenine glycosylase
H4B46_RS05500	COG2818	Glycosylase
H4B46_RS05505	COG1064	alcohol dehydrogenase
H4B46_RS05510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B46_RS05525	COG0583	DNA-binding transcription factor activity
H4B46_RS05530	COG0656	L-ascorbic acid biosynthetic process
H4B46_RS05535	COG2814	Major facilitator Superfamily
H4B46_RS05570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS05585	COG2233	PERMEase
H4B46_RS05590	COG0583	DNA-binding transcription factor activity
H4B46_RS05625	COG0733	neurotransmitter:sodium symporter activity
H4B46_RS05665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4B46_RS05670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H4B46_RS05675	COG0596	Alpha beta hydrolase
H4B46_RS05700	COG0488	(ABC) transporter
H4B46_RS05705	COG0586	Pfam SNARE associated Golgi protein
H4B46_RS05715	COG0187	DNA topoisomerase II activity
H4B46_RS05725	COG0592	DNA-directed DNA polymerase activity
H4B46_RS05755	COG0706	membrane insertase activity
H4B46_RS05770	COG1230	cation diffusion facilitator family transporter
H4B46_RS05775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B46_RS05790	COG0402	S-adenosylhomocysteine deaminase activity
H4B46_RS05800	COG0754	glutathionylspermidine amidase activity
H4B46_RS05810	COG0861	Integral membrane protein TerC family
H4B46_RS05815	COG0671	phosphoesterase, PA-phosphatase related
H4B46_RS05825	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4B46_RS05840	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4B46_RS05845	COG2951	lytic endotransglycosylase activity
H4B46_RS05895	COG0657	acetylesterase activity
H4B46_RS05900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4B46_RS05940	COG1047	Peptidyl-prolyl cis-trans
H4B46_RS05950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H4B46_RS05955	COG0196	riboflavin kinase activity
H4B46_RS05965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4B46_RS05970	COG1309	transcriptional regulator
H4B46_RS05975	COG1116	anion transmembrane transporter activity
H4B46_RS05980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4B46_RS05985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B46_RS05990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B46_RS05995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B46_RS06015	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS06030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4B46_RS06040	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H4B46_RS06045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4B46_RS06130	COG0534	Mate efflux family protein
H4B46_RS06135	COG0436	Aminotransferase
H4B46_RS06140	COG2733	membrane
H4B46_RS06155	COG2918	glutathione biosynthetic process
H4B46_RS06170	COG3179	chitinase
H4B46_RS06185	COG3150	esterase
H4B46_RS06195	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H4B46_RS06205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B46_RS06215	COG2233	PERMEase
H4B46_RS06220	COG2351	hydroxyisourate hydrolase activity
H4B46_RS06305	COG0482	sulfurtransferase activity
H4B46_RS06320	COG0488	(ABC) transporter
H4B46_RS06325	COG3173	Aminoglycoside phosphotransferase
H4B46_RS06420	COG1192	Involved in chromosome partitioning
H4B46_RS06465	COG1126	abc transporter atp-binding protein
H4B46_RS06480	COG0546	phosphoglycolate phosphatase activity
H4B46_RS06495	COG3706	GGDEF domain
H4B46_RS06510	COG1393	Belongs to the ArsC family
H4B46_RS06515	COG0708	Exodeoxyribonuclease III
H4B46_RS06540	COG0189	ligase activity
H4B46_RS06560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4B46_RS06570	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4B46_RS06585	COG4942	peptidase
H4B46_RS06595	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4B46_RS06605	COG2119	membrane
H4B46_RS06610	COG4774	siderophore transport
H4B46_RS06615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS06615	COG0426	domain, Protein
H4B46_RS06640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H4B46_RS06665	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS06670	COG1519	Transferase
H4B46_RS06675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4B46_RS06680	COG0668	transmembrane transport
H4B46_RS06690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B46_RS06695	COG1335	isochorismatase
H4B46_RS06700	COG1522	sequence-specific DNA binding
H4B46_RS06725	COG2205	protein histidine kinase activity
H4B46_RS06725	COG2198	Histidine kinase
H4B46_RS06725	COG0784	Response regulator, receiver
H4B46_RS06730	COG3162	membrane
H4B46_RS06735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4B46_RS06745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B46_RS06765	COG1309	transcriptional regulator
H4B46_RS06785	COG0351	phosphomethylpyrimidine kinase
H4B46_RS06785	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4B46_RS06785	COG0352	thiamine-phosphate diphosphorylase activity
H4B46_RS06795	COG2814	Major facilitator Superfamily
H4B46_RS06810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4B46_RS06820	COG1113	amino acid transport
H4B46_RS06830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H4B46_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS06845	COG1335	isochorismatase
H4B46_RS06875	COG2814	Major facilitator Superfamily
H4B46_RS06880	COG0583	DNA-binding transcription factor activity
H4B46_RS06900	COG0667	Aldo Keto reductase
H4B46_RS06920	COG2963	transposase activity
H4B46_RS06940	COG1733	regulation of RNA biosynthetic process
H4B46_RS06945	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS07005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H4B46_RS07060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4B46_RS07090	COG0427	acetyl-CoA hydrolase
H4B46_RS07115	COG0659	secondary active sulfate transmembrane transporter activity
H4B46_RS07120	COG4221	oxidoreductase activity
H4B46_RS07130	COG0488	(ABC) transporter
H4B46_RS07195	COG0833	amino acid
H4B46_RS07240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4B46_RS07245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4B46_RS07260	COG2226	methyltransferase
H4B46_RS07310	COG0067	glutamate synthase
H4B46_RS07310	COG0070	glutamate synthase
H4B46_RS07310	COG0069	glutamate synthase activity
H4B46_RS07315	COG0493	'glutamate synthase
H4B46_RS07325	COG1704	LemA family
H4B46_RS07330	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H4B46_RS07350	COG3307	-O-antigen
H4B46_RS07370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4B46_RS07385	COG0194	GDP metabolic process
H4B46_RS07435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4B46_RS07455	COG5380	lipid catabolic process
H4B46_RS07460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H4B46_RS07485	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4B46_RS07490	COG0277	FAD linked oxidase domain protein
H4B46_RS07505	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H4B46_RS07510	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS07525	COG1289	transmembrane transporter activity
H4B46_RS07535	COG0628	permease
H4B46_RS07540	COG1192	Involved in chromosome partitioning
H4B46_RS07570	COG0833	amino acid
H4B46_RS07575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4B46_RS07580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4B46_RS07590	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS07630	COG0583	DNA-binding transcription factor activity
H4B46_RS07680	COG0517	IMP dehydrogenase activity
H4B46_RS07685	COG1983	PspC domain protein
H4B46_RS07695	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS07710	COG0408	coproporphyrinogen oxidase activity
H4B46_RS07730	COG0513	Belongs to the DEAD box helicase family
H4B46_RS07740	COG1127	ABC transporter
H4B46_RS07745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4B46_RS07755	COG2854	intermembrane phospholipid transfer
H4B46_RS07765	COG0598	Magnesium transport protein CorA
H4B46_RS07775	COG0494	nUDIX hydrolase
H4B46_RS07780	COG1040	competence protein
H4B46_RS07785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4B46_RS07805	COG1946	Acyl-CoA thioesterase
H4B46_RS07810	COG1301	dicarboxylic acid transport
H4B46_RS07825	COG1959	2 iron, 2 sulfur cluster binding
H4B46_RS07830	COG1017	nitric oxide dioxygenase activity
H4B46_RS07830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B46_RS07840	COG0433	COG0433 Predicted ATPase
H4B46_RS07845	COG0626	cystathionine gamma-synthase activity
H4B46_RS08000	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS08005	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H4B46_RS08040	COG2963	transposase activity
H4B46_RS08050	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H4B46_RS08055	COG0339	signal peptide processing
H4B46_RS08060	COG0557	exoribonuclease II activity
H4B46_RS08110	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4B46_RS08115	COG2169	Transcriptional regulator
H4B46_RS08120	COG0697	spore germination
H4B46_RS08125	COG1295	ribonuclease BN
H4B46_RS08160	COG1702	phosphate starvation-inducible protein PhoH
H4B46_RS08170	COG1196	nuclear chromosome segregation
H4B46_RS08170	COG0741	lytic transglycosylase activity
H4B46_RS08170	COG0739	heme binding
H4B46_RS08200	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4B46_RS08205	COG1183	phosphatidylcholine synthase activity
H4B46_RS08250	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS08255	COG1309	transcriptional regulator
H4B46_RS08270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4B46_RS08275	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS08295	COG2969	positive regulation of protein catabolic process
H4B46_RS08305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4B46_RS08315	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4B46_RS08320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H4B46_RS08325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4B46_RS08345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4B46_RS08355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4B46_RS08360	COG1408	metallophosphoesterase
H4B46_RS08370	COG2199	diguanylate cyclase activity
H4B46_RS08430	COG1607	acyl-coa hydrolase
H4B46_RS08460	COG2350	Protein conserved in bacteria
H4B46_RS08470	COG0613	PHP domain protein
H4B46_RS08475	COG3781	membrane
H4B46_RS08485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4B46_RS08490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4B46_RS08500	COG1862	Preprotein translocase
H4B46_RS08530	COG2205	protein histidine kinase activity
H4B46_RS08535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4B46_RS08555	COG0726	polysaccharide deacetylase
H4B46_RS08560	COG0463	Glycosyl transferase, family 2
H4B46_RS08565	COG0438	transferase activity, transferring glycosyl groups
H4B46_RS08630	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS08635	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS08645	COG2205	protein histidine kinase activity
H4B46_RS08650	COG0745	RESPONSE REGULATOR receiver
H4B46_RS08655	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4B46_RS08675	COG2096	Adenosyltransferase
H4B46_RS08725	COG0285	dihydrofolate synthase activity
H4B46_RS08745	COG0450	alkyl hydroperoxide reductase
H4B46_RS08760	COG0477	Major facilitator Superfamily
H4B46_RS08765	COG1272	protein, Hemolysin III
H4B46_RS08795	COG0183	Belongs to the thiolase family
H4B46_RS08800	COG2207	Transcriptional regulator
H4B46_RS08820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B46_RS08840	COG0183	Belongs to the thiolase family
H4B46_RS08850	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4B46_RS08850	COG2885	chlorophyll binding
H4B46_RS08860	COG1690	Belongs to the RtcB family
H4B46_RS08865	COG0833	amino acid
H4B46_RS08875	COG2233	PERMEase
H4B46_RS08880	COG1217	gtp-binding protein TYPA
H4B46_RS08905	COG2094	Belongs to the DNA glycosylase MPG family
H4B46_RS08915	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS08920	COG0679	Auxin Efflux Carrier
H4B46_RS08930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H4B46_RS08935	COG0354	folic acid binding
H4B46_RS08945	COG3189	MarR family transcriptional regulator
H4B46_RS08950	COG2824	Alkylphosphonate utilization operon protein PhnA
H4B46_RS08955	COG3422	double-strand break repair
H4B46_RS08995	COG0840	transmembrane signaling receptor activity
H4B46_RS09015	COG5510	response to toxic substance
H4B46_RS09025	COG2832	Protein of unknown function (DUF454)
H4B46_RS09030	COG1376	ErfK ybiS ycfS ynhG family protein
H4B46_RS09070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4B46_RS09080	COG1289	transmembrane transporter activity
H4B46_RS09085	COG2814	Major facilitator Superfamily
H4B46_RS09105	COG1115	amino acid carrier protein
H4B46_RS09110	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4B46_RS09115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4B46_RS09120	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H4B46_RS09145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4B46_RS09155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H4B46_RS09160	COG1077	Cell shape determining protein MreB Mrl
H4B46_RS09165	COG1792	Involved in formation and maintenance of cell shape
H4B46_RS09170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4B46_RS09175	COG0424	maF-like protein
H4B46_RS09180	COG1530	ribonuclease E activity
H4B46_RS09190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H4B46_RS09200	COG0560	Phosphoserine phosphatase
H4B46_RS09210	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS09235	COG2207	Transcriptional regulator
H4B46_RS09270	COG2963	transposase activity
H4B46_RS09310	COG1214	PFAM Peptidase M22, glycoprotease
H4B46_RS09335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4B46_RS09340	COG0561	phosphatase activity
H4B46_RS09350	COG2132	Multicopper oxidase
H4B46_RS09370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4B46_RS09375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H4B46_RS09380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4B46_RS09410	COG1063	alcohol dehydrogenase
H4B46_RS09415	COG0583	DNA-binding transcription factor activity
H4B46_RS09420	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS09425	COG2814	Major facilitator Superfamily
H4B46_RS09430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B46_RS09435	COG1309	transcriptional regulator
H4B46_RS09450	COG1053	succinate dehydrogenase
H4B46_RS09455	COG0583	DNA-binding transcription factor activity
H4B46_RS09470	COG0583	DNA-binding transcription factor activity
H4B46_RS09480	COG0583	DNA-binding transcription factor activity
H4B46_RS09495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS09540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4B46_RS09560	COG0745	RESPONSE REGULATOR receiver
H4B46_RS09575	COG3706	GGDEF domain
H4B46_RS09600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4B46_RS09630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4B46_RS09635	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4B46_RS09660	COG0583	DNA-binding transcription factor activity
H4B46_RS09680	COG0668	transmembrane transport
H4B46_RS09690	COG2081	HI0933 family
H4B46_RS09695	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H4B46_RS09725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B46_RS09725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4B46_RS09735	COG0489	protein tyrosine kinase activity
H4B46_RS09785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4B46_RS09795	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4B46_RS09810	COG0730	response to heat
H4B46_RS09820	COG1196	nuclear chromosome segregation
H4B46_RS09840	COG2223	nitrite transmembrane transporter activity
H4B46_RS09845	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H4B46_RS09850	COG1877	trehalose-phosphatase activity
H4B46_RS09855	COG2226	methyltransferase
H4B46_RS09855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B46_RS09855	COG0596	Alpha beta hydrolase
H4B46_RS09870	COG4106	trans-aconitate 2-methyltransferase activity
H4B46_RS09885	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4B46_RS09890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4B46_RS09895	COG0009	L-threonylcarbamoyladenylate synthase
H4B46_RS09900	COG3101	peptidyl-lysine hydroxylation
H4B46_RS09905	COG1399	metal-binding, possibly nucleic acid-binding protein
H4B46_RS09930	COG1652	LysM domain
H4B46_RS09935	COG0351	phosphomethylpyrimidine kinase
H4B46_RS09935	COG0352	thiamine-phosphate diphosphorylase activity
H4B46_RS09935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4B46_RS09945	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4B46_RS09975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4B46_RS10005	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H4B46_RS10020	COG0358	DNA primase activity
H4B46_RS10030	COG0564	pseudouridine synthase activity
H4B46_RS10055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B46_RS10075	COG0583	DNA-binding transcription factor activity
H4B46_RS10080	COG0473	3-isopropylmalate dehydrogenase activity
H4B46_RS10090	COG0657	acetylesterase activity
H4B46_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS10120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4B46_RS10120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4B46_RS10135	COG1981	membrane
H4B46_RS10180	COG0456	acetyltransferase
H4B46_RS10190	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4B46_RS10195	COG0492	ferredoxin-NADP+ reductase activity
H4B46_RS10200	COG1674	ftsk spoiiie
H4B46_RS10200	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4B46_RS10205	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS10220	COG2894	cell division
H4B46_RS10235	COG0204	Acyl-transferase
H4B46_RS10240	COG2885	chlorophyll binding
H4B46_RS10245	COG0210	DNA helicase
H4B46_RS10255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4B46_RS10270	COG0121	glutamine amidotransferase
H4B46_RS10290	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4B46_RS10295	COG0735	belongs to the Fur family
H4B46_RS10320	COG0420	3'-5' exonuclease activity
H4B46_RS10340	COG1090	epimerase
H4B46_RS10355	COG2050	protein possibly involved in aromatic compounds catabolism
H4B46_RS10365	COG2814	Major facilitator Superfamily
H4B46_RS10370	COG0405	Gamma-glutamyltransferase
H4B46_RS10380	COG0582	viral genome integration into host DNA
H4B46_RS10470	COG2963	transposase activity
H4B46_RS10485	COG2963	transposase activity
H4B46_RS10505	COG0477	Major facilitator Superfamily
H4B46_RS10555	COG0531	amino acid
H4B46_RS10560	COG2040	homocysteine
H4B46_RS10585	COG1309	transcriptional regulator
H4B46_RS10590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B46_RS10595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H4B46_RS10605	COG1607	acyl-coa hydrolase
H4B46_RS10615	COG0523	cobalamin synthesis protein
H4B46_RS10625	COG4681	YaeQ
H4B46_RS10635	COG1649	PFAM Uncharacterised BCR, COG1649
H4B46_RS10635	COG0726	polysaccharide deacetylase
H4B46_RS10640	COG1215	transferase activity, transferring glycosyl groups
H4B46_RS10650	COG1024	Enoyl-CoA hydratase
H4B46_RS10665	COG1414	Transcriptional regulator
H4B46_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS10700	COG2271	Major facilitator Superfamily
H4B46_RS10710	COG2267	carboxylic ester hydrolase activity
H4B46_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS10730	COG0028	Belongs to the TPP enzyme family
H4B46_RS10740	COG0477	Major facilitator Superfamily
H4B46_RS10745	COG0242	peptide deformylase activity
H4B46_RS10750	COG2066	Belongs to the glutaminase family
H4B46_RS10755	COG2207	Transcriptional regulator
H4B46_RS10760	COG2223	nitrite transmembrane transporter activity
H4B46_RS10775	COG0583	DNA-binding transcription factor activity
H4B46_RS10780	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS10785	COG2271	Major facilitator Superfamily
H4B46_RS10790	COG3959	Transketolase, thiamine diphosphate binding domain
H4B46_RS10795	COG3958	Transketolase
H4B46_RS10805	COG0306	phosphate transporter
H4B46_RS10825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4B46_RS10870	COG4181	ATPase activity
H4B46_RS10875	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4B46_RS10905	COG0583	DNA-binding transcription factor activity
H4B46_RS10915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B46_RS10920	COG1773	rubredoxin
H4B46_RS10970	COG2851	Citrate transporter
H4B46_RS10975	COG1253	flavin adenine dinucleotide binding
H4B46_RS11015	COG0804	urea catabolic process
H4B46_RS11025	COG0830	nickel cation binding
H4B46_RS11040	COG0742	ribosomal rna small subunit methyltransferase
H4B46_RS11045	COG0768	penicillin binding
H4B46_RS11070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4B46_RS11075	COG2878	Part of a membrane complex involved in electron transport
H4B46_RS11080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4B46_RS11090	COG3384	dioxygenase
H4B46_RS11115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4B46_RS11325	COG0006	proline dipeptidase activity
H4B46_RS11330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B46_RS11335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B46_RS11355	COG1279	arginine transmembrane transporter activity
H4B46_RS11360	COG0583	DNA-binding transcription factor activity
H4B46_RS11400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4B46_RS11405	COG0741	lytic transglycosylase activity
H4B46_RS11405	COG1388	LysM domain
H4B46_RS11405	COG0741	lytic transglycosylase activity
H4B46_RS11405	COG1388	LysM domain
H4B46_RS11415	COG4174	ABC transporter (Permease)
H4B46_RS11420	COG4239	(ABC) transporter, permease
H4B46_RS11425	COG4172	Belongs to the ABC transporter superfamily
H4B46_RS11445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4B46_RS11455	COG3706	GGDEF domain
H4B46_RS11455	COG5001	Diguanylate cyclase
H4B46_RS11455	COG2203	Gaf domain
H4B46_RS11455	COG4251	negative regulation of phosphorylation
H4B46_RS11465	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4B46_RS11465	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS11480	COG4269	membrane
H4B46_RS11525	COG1113	amino acid transport
H4B46_RS11535	COG0531	amino acid
H4B46_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS11575	COG1113	amino acid transport
H4B46_RS11590	COG0697	spore germination
H4B46_RS11595	COG2721	sulfolactate sulfo-lyase activity
H4B46_RS11600	COG2271	Major facilitator Superfamily
H4B46_RS11605	COG4948	Mandelate Racemase Muconate Lactonizing
H4B46_RS11615	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS11620	COG2186	Transcriptional regulator
H4B46_RS11645	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS11660	COG1024	Enoyl-CoA hydratase
H4B46_RS11665	COG2814	Major facilitator Superfamily
H4B46_RS11680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B46_RS11695	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4B46_RS11740	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
H4B46_RS11745	COG2072	flavoprotein involved in K transport
H4B46_RS11750	COG0300	oxidoreductase activity
H4B46_RS11765	COG1741	Belongs to the pirin family
H4B46_RS11780	COG2072	flavoprotein involved in K transport
H4B46_RS11790	COG2252	PERMEase
H4B46_RS11795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H4B46_RS11800	COG3038	cytochrome b561
H4B46_RS11810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4B46_RS11820	COG0527	aspartate kinase activity
H4B46_RS11830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4B46_RS11845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4B46_RS11860	COG0667	Aldo Keto reductase
H4B46_RS11875	COG1765	OsmC-like protein
H4B46_RS11890	COG0542	response to heat
H4B46_RS11925	COG2885	chlorophyll binding
H4B46_RS11935	COG0625	glutathione transferase activity
H4B46_RS11940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4B46_RS11960	COG3634	alkyl hydroperoxide reductase activity
H4B46_RS11970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4B46_RS11980	COG0450	alkyl hydroperoxide reductase
H4B46_RS11985	COG1643	Atp-dependent helicase
H4B46_RS12000	COG2814	Major facilitator Superfamily
H4B46_RS12005	COG3135	benzoate transporter
H4B46_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS12015	COG0543	2 iron, 2 sulfur cluster binding
H4B46_RS12015	COG0633	Ferredoxin
H4B46_RS12020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4B46_RS12025	COG4638	Rieske (2fe-2S)
H4B46_RS12030	COG0583	DNA-binding transcription factor activity
H4B46_RS12080	COG1570	exodeoxyribonuclease VII activity
H4B46_RS12110	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS12115	COG1278	Cold shock
H4B46_RS12150	COG2814	Major facilitator Superfamily
H4B46_RS12190	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4B46_RS12200	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H4B46_RS12205	COG1137	ATPase activity
H4B46_RS12210	COG1538	Outer membrane efflux protein
H4B46_RS12240	COG4122	O-methyltransferase activity
H4B46_RS12250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4B46_RS12265	COG1522	sequence-specific DNA binding
H4B46_RS12280	COG1560	Kdo2-lipid A biosynthetic process
H4B46_RS12290	COG2814	Major facilitator Superfamily
H4B46_RS12310	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B46_RS12345	COG0583	DNA-binding transcription factor activity
H4B46_RS12350	COG1914	H( )-stimulated, divalent metal cation uptake system
H4B46_RS12370	COG4770	biotin carboxylase activity
H4B46_RS12375	COG0038	chloride channel
H4B46_RS12380	COG2831	hemolysin activation secretion protein
H4B46_RS12385	COG3210	domain, Protein
H4B46_RS12410	COG1063	alcohol dehydrogenase
H4B46_RS12425	COG0439	Biotin carboxylase
H4B46_RS12430	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4B46_RS12435	COG1733	regulation of RNA biosynthetic process
H4B46_RS12450	COG0864	Transcriptional regulator
H4B46_RS12460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B46_RS12465	COG1116	anion transmembrane transporter activity
H4B46_RS12585	COG0590	tRNA wobble adenosine to inosine editing
H4B46_RS12590	COG2807	transmembrane transport
H4B46_RS12605	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4B46_RS12615	COG0789	Transcriptional regulator
H4B46_RS12625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4B46_RS12645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4B46_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS12675	COG0531	amino acid
H4B46_RS12680	COG1760	l-serine dehydratase
H4B46_RS12685	COG2030	dehydratase
H4B46_RS12685	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS12690	COG3396	Phenylacetate-CoA oxygenase
H4B46_RS12695	COG3460	Phenylacetate-CoA oxygenase
H4B46_RS12700	COG3396	Phenylacetate-CoA oxygenase
H4B46_RS12705	COG2151	metal-sulfur cluster biosynthetic enzyme
H4B46_RS12710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B46_RS12715	COG1024	Enoyl-CoA hydratase
H4B46_RS12720	COG1024	Enoyl-CoA hydratase
H4B46_RS12725	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B46_RS12730	COG0183	Belongs to the thiolase family
H4B46_RS12735	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H4B46_RS12740	COG3327	negative regulation of DNA-templated transcription, initiation
H4B46_RS12750	COG2050	protein possibly involved in aromatic compounds catabolism
H4B46_RS12775	COG0753	catalase activity
H4B46_RS12780	COG3038	cytochrome b561
H4B46_RS12800	COG2267	carboxylic ester hydrolase activity
H4B46_RS12805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS12810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B46_RS12825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4B46_RS12835	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS12840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4B46_RS12845	COG0583	DNA-binding transcription factor activity
H4B46_RS12855	COG1414	Transcriptional regulator
H4B46_RS12860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4B46_RS12870	COG1840	ABC-type Fe3 transport system, periplasmic component
H4B46_RS12875	COG3842	ATPase activity
H4B46_RS12890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H4B46_RS12895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4B46_RS12900	COG2814	Major facilitator Superfamily
H4B46_RS12905	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS12910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B46_RS12920	COG1024	Enoyl-CoA hydratase
H4B46_RS12930	COG2814	Major facilitator Superfamily
H4B46_RS12940	COG0183	Belongs to the thiolase family
H4B46_RS12945	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4B46_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS12955	COG1024	Enoyl-CoA hydratase
H4B46_RS12960	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS12965	COG2814	Major facilitator Superfamily
H4B46_RS12970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B46_RS12975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4B46_RS12985	COG2814	Major facilitator Superfamily
H4B46_RS12995	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS13010	COG0583	DNA-binding transcription factor activity
H4B46_RS13020	COG4770	biotin carboxylase activity
H4B46_RS13025	COG1024	Enoyl-CoA hydratase
H4B46_RS13030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4B46_RS13035	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS13040	COG1309	transcriptional regulator
H4B46_RS13045	COG0318	PFAM AMP-dependent synthetase and ligase
H4B46_RS13065	COG0583	DNA-binding transcription factor activity
H4B46_RS13150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4B46_RS13170	COG0784	Response regulator, receiver
H4B46_RS13170	COG2205	protein histidine kinase activity
H4B46_RS13190	COG0765	amino acid transport
H4B46_RS13195	COG0765	amino acid transport
H4B46_RS13200	COG1126	abc transporter atp-binding protein
H4B46_RS13205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B46_RS13210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4B46_RS13225	COG1280	lysine exporter protein (LysE YggA)
H4B46_RS13230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4B46_RS13235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4B46_RS13240	COG1045	serine acetyltransferase
H4B46_RS13255	COG0583	DNA-binding transcription factor activity
H4B46_RS13260	COG0625	glutathione transferase activity
H4B46_RS13265	COG0625	glutathione transferase activity
H4B46_RS13270	COG0583	DNA-binding transcription factor activity
H4B46_RS13280	COG1346	cytolysis
H4B46_RS13300	COG2814	Major facilitator Superfamily
H4B46_RS13310	COG0583	DNA-binding transcription factor activity
H4B46_RS13320	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H4B46_RS13325	COG3052	prosthetic group binding
H4B46_RS13345	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4B46_RS13365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B46_RS13375	COG1294	oxidase, subunit
H4B46_RS13380	COG1271	oxidase subunit
H4B46_RS13400	COG0477	Major facilitator Superfamily
H4B46_RS13410	COG4521	taurine ABC transporter
H4B46_RS13415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H4B46_RS13420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4B46_RS13425	COG2175	clavaminate synthase activity
H4B46_RS13435	COG1953	Uracil, thiamine, allantoin
H4B46_RS13445	COG0583	DNA-binding transcription factor activity
H4B46_RS13455	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4B46_RS13470	COG0640	Transcriptional regulator
H4B46_RS13475	COG0798	PFAM Bile acid sodium symporter
H4B46_RS13480	COG0583	DNA-binding transcription factor activity
H4B46_RS13495	COG3634	alkyl hydroperoxide reductase activity
H4B46_RS13535	COG0436	Aminotransferase
H4B46_RS13545	COG0386	Belongs to the glutathione peroxidase family
H4B46_RS13585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4B46_RS13610	COG0012	GTP binding
H4B46_RS13615	COG2011	ABC-type metal ion transport system permease component
H4B46_RS13620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4B46_RS13630	COG1464	Belongs to the NlpA lipoprotein family
H4B46_RS13660	COG0765	amino acid transport
H4B46_RS13665	COG0765	amino acid transport
H4B46_RS13670	COG1126	abc transporter atp-binding protein
H4B46_RS13680	COG1522	sequence-specific DNA binding
H4B46_RS13695	COG1309	transcriptional regulator
H4B46_RS13715	COG0583	DNA-binding transcription factor activity
H4B46_RS13725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H4B46_RS13735	COG0697	spore germination
H4B46_RS13760	COG3121	Chaperone
H4B46_RS13765	COG3539	Fimbrial protein
H4B46_RS13790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4B46_RS13790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4B46_RS13835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4B46_RS13845	COG2353	YceI-like domain
H4B46_RS13855	COG3698	Phosphodiester glycosidase
H4B46_RS13870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H4B46_RS13875	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4B46_RS13875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H4B46_RS13875	COG0506	proline dehydrogenase activity
H4B46_RS13885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4B46_RS13890	COG2963	transposase activity
H4B46_RS13905	COG1414	Transcriptional regulator
H4B46_RS13910	COG2851	Citrate transporter
H4B46_RS13915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4B46_RS13920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4B46_RS13925	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS13940	COG2207	Transcriptional regulator
H4B46_RS13950	COG2205	protein histidine kinase activity
H4B46_RS13955	COG0745	RESPONSE REGULATOR receiver
H4B46_RS13960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS13965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4B46_RS13985	COG3539	Fimbrial protein
H4B46_RS14010	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H4B46_RS14020	COG0753	catalase activity
H4B46_RS14035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4B46_RS14100	COG3433	isochorismatase activity
H4B46_RS14100	COG1535	isochorismatase
H4B46_RS14105	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS14110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4B46_RS14115	COG4149	molybdate abc transporter
H4B46_RS14120	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4B46_RS14130	COG4638	Rieske (2fe-2S)
H4B46_RS14135	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H4B46_RS14140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4B46_RS14140	COG0543	2 iron, 2 sulfur cluster binding
H4B46_RS14155	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS14185	COG2963	transposase activity
H4B46_RS14200	COG2207	Transcriptional regulator
H4B46_RS14205	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS14210	COG2610	gluconate transmembrane transporter activity
H4B46_RS14220	COG1309	transcriptional regulator
H4B46_RS14235	COG0583	DNA-binding transcription factor activity
H4B46_RS14250	COG2031	fatty acid transporter
H4B46_RS14255	COG0183	Belongs to the thiolase family
H4B46_RS14260	COG0583	DNA-binding transcription factor activity
H4B46_RS14265	COG0583	DNA-binding transcription factor activity
H4B46_RS14280	COG1027	Aspartate ammonia-lyase
H4B46_RS14290	COG0477	Major facilitator Superfamily
H4B46_RS14315	COG4521	taurine ABC transporter
H4B46_RS14330	COG2188	Transcriptional regulator
H4B46_RS14340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4B46_RS14345	COG1733	regulation of RNA biosynthetic process
H4B46_RS14350	COG3708	Transcriptional regulator
H4B46_RS14350	COG2207	Transcriptional regulator
H4B46_RS14365	COG0730	response to heat
H4B46_RS14375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B46_RS14375	COG3453	Protein conserved in bacteria
H4B46_RS14385	COG3781	membrane
H4B46_RS14390	COG1063	alcohol dehydrogenase
H4B46_RS14400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B46_RS14405	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4B46_RS14410	COG0022	dehydrogenase e1 component
H4B46_RS14415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4B46_RS14420	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4B46_RS14435	COG3706	GGDEF domain
H4B46_RS14450	COG0133	tryptophan synthase activity
H4B46_RS14460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4B46_RS14495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4B46_RS14520	COG2226	methyltransferase
H4B46_RS14575	COG0842	Transport permease protein
H4B46_RS14580	COG0842	Transport permease protein
H4B46_RS14585	COG1131	(ABC) transporter
H4B46_RS14600	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B46_RS14605	COG4773	Receptor
H4B46_RS14625	COG0730	response to heat
H4B46_RS14630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4B46_RS14650	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H4B46_RS14665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4B46_RS14695	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4B46_RS14705	COG4264	IucA IucC family
H4B46_RS14710	COG4264	IucA IucC family
H4B46_RS14730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4B46_RS14745	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS14750	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS14755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4B46_RS14760	COG2207	Transcriptional regulator
H4B46_RS14765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4B46_RS14770	COG0776	regulation of translation
H4B46_RS14795	COG0822	iron-sulfur transferase activity
H4B46_RS14800	COG0316	Belongs to the HesB IscA family
H4B46_RS14830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4B46_RS14850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4B46_RS14855	COG0702	epimerase
H4B46_RS14890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4B46_RS14900	COG0339	signal peptide processing
H4B46_RS14945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4B46_RS14950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4B46_RS14980	COG0776	regulation of translation
H4B46_RS15045	COG0084	hydrolase, TatD family'
H4B46_RS15065	COG1663	tetraacyldisaccharide 4'-kinase activity
H4B46_RS15070	COG1132	(ABC) transporter
H4B46_RS15080	COG0811	peptide transport
H4B46_RS15085	COG1475	DNA binding
H4B46_RS15090	COG1192	Involved in chromosome partitioning
H4B46_RS15100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4B46_RS15115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4B46_RS15120	COG0191	fructose-bisphosphate aldolase activity
H4B46_RS15140	COG0424	maF-like protein
H4B46_RS15145	COG2850	peptidyl-arginine hydroxylation
H4B46_RS15155	COG0640	Transcriptional regulator
H4B46_RS15165	COG3619	membrane
H4B46_RS15170	COG3122	Protein conserved in bacteria
H4B46_RS15175	COG1132	(ABC) transporter
H4B46_RS15195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4B46_RS15210	COG2963	transposase activity
H4B46_RS15215	COG0583	DNA-binding transcription factor activity
H4B46_RS15300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H4B46_RS15350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4B46_RS15370	COG1120	ATPase activity
H4B46_RS15375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4B46_RS15385	COG1064	alcohol dehydrogenase
H4B46_RS15400	COG2207	Transcriptional regulator
H4B46_RS15405	COG2084	Dehydrogenase
H4B46_RS15415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4B46_RS15420	COG0583	DNA-binding transcription factor activity
H4B46_RS15430	COG0129	dihydroxy-acid dehydratase activity
H4B46_RS15450	COG1566	PFAM secretion protein HlyD family protein
H4B46_RS15475	COG0583	DNA-binding transcription factor activity
H4B46_RS15490	COG2188	Transcriptional regulator
H4B46_RS15525	COG4191	Histidine kinase
H4B46_RS15540	COG1473	amidohydrolase
H4B46_RS15550	COG0475	glutathione-regulated potassium exporter activity
H4B46_RS15550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4B46_RS15560	COG0583	DNA-binding transcription factor activity
H4B46_RS15565	COG1335	isochorismatase
H4B46_RS15575	COG1309	transcriptional regulator
H4B46_RS15615	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4B46_RS15615	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS15650	COG2186	Transcriptional regulator
H4B46_RS15660	COG0583	DNA-binding transcription factor activity
H4B46_RS15665	COG4948	Mandelate Racemase Muconate Lactonizing
H4B46_RS15670	COG4829	muconolactone delta-isomerase
H4B46_RS15680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B46_RS15685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4B46_RS15690	COG0183	Belongs to the thiolase family
H4B46_RS15695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4B46_RS15705	COG1012	belongs to the aldehyde dehydrogenase family
H4B46_RS15715	COG3733	amine oxidase
H4B46_RS15725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS15735	COG1028	Short-chain dehydrogenase reductase Sdr
H4B46_RS15745	COG4638	Rieske (2fe-2S)
H4B46_RS15765	COG0154	amidase activity
H4B46_RS15775	COG2814	Major facilitator Superfamily
H4B46_RS15800	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS15805	COG0583	DNA-binding transcription factor activity
H4B46_RS15810	COG1414	Transcriptional regulator
H4B46_RS15825	COG2391	methyltransferase activity
H4B46_RS15835	COG4993	Dehydrogenase
H4B46_RS15840	COG3659	wide pore channel activity
H4B46_RS15845	COG3420	alginic acid biosynthetic process
H4B46_RS15850	COG0710	3-dehydroquinate dehydratase activity
H4B46_RS15855	COG3485	protocatechuate 3,4-dioxygenase
H4B46_RS15860	COG3485	protocatechuate 3,4-dioxygenase
H4B46_RS15865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4B46_RS15870	COG2271	Major facilitator Superfamily
H4B46_RS15875	COG0596	Alpha beta hydrolase
H4B46_RS15880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4B46_RS15885	COG0183	Belongs to the thiolase family
H4B46_RS15890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H4B46_RS15895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H4B46_RS15905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H4B46_RS15910	COG2323	membrane
H4B46_RS15960	COG1902	pentaerythritol trinitrate reductase activity
H4B46_RS15960	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4B46_RS15985	COG0542	response to heat
H4B46_RS15990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H4B46_RS16020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4B46_RS16025	COG0569	domain protein
H4B46_RS16030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4B46_RS16045	COG4774	siderophore transport
H4B46_RS16050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4B46_RS16060	COG1585	Membrane protein implicated in regulation of membrane protease activity
H4B46_RS16075	COG1294	oxidase, subunit
H4B46_RS16080	COG4890	Cyd operon protein YbgT
H4B46_RS16090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H4B46_RS16100	COG0552	protein localization to endoplasmic reticulum
H4B46_RS16125	COG0517	IMP dehydrogenase activity
H4B46_RS16125	COG0516	GMP reductase activity
H4B46_RS16130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4B46_RS16135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4B46_RS16145	COG0583	DNA-binding transcription factor activity
H4B46_RS16150	COG0024	Methionine aminopeptidase
H4B46_RS16180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4B46_RS16180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4B46_RS16185	COG1105	Belongs to the carbohydrate kinase PfkB family
H4B46_RS16190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4B46_RS16190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H4B46_RS16190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H4B46_RS16205	COG5001	Diguanylate cyclase
H4B46_RS16205	COG3300	MHYT domain
H4B46_RS16220	COG2963	transposase activity
H4B46_RS16235	COG2963	transposase activity
H4B46_RS16250	COG2135	peptidase activity
H4B46_RS16255	COG0659	secondary active sulfate transmembrane transporter activity
H4B46_RS16270	COG1113	amino acid transport
H4B46_RS16280	COG1522	sequence-specific DNA binding
H4B46_RS16305	COG1011	Hydrolase
H4B46_RS16310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H4B46_RS16320	COG2137	regulation of response to DNA damage stimulus
H4B46_RS16335	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B46_RS16370	COG0575	Belongs to the CDS family
H4B46_RS16375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4B46_RS16400	COG3852	Histidine kinase
H4B46_RS16405	COG2204	response regulator
H4B46_RS16460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4B46_RS16465	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H4B46_RS16485	COG0697	spore germination
H4B46_RS16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B46_RS16500	COG0303	'Molybdopterin
H4B46_RS16505	COG0315	cyclic pyranopterin monophosphate synthase activity
H4B46_RS16505	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4B46_RS16520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4B46_RS16525	COG0243	molybdopterin cofactor binding
H4B46_RS16535	COG0243	molybdopterin cofactor binding
H4B46_RS16540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B46_RS16545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4B46_RS16545	COG2146	nitrite reductase [NAD(P)H] activity
H4B46_RS16555	COG0745	RESPONSE REGULATOR receiver
H4B46_RS16560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H4B46_RS16560	COG1116	anion transmembrane transporter activity
H4B46_RS16575	COG0511	ligase activity, forming carbon-carbon bonds
H4B46_RS16590	COG2814	Major facilitator Superfamily
H4B46_RS16610	COG0069	glutamate synthase activity
H4B46_RS16630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4B46_RS16640	COG1454	alcohol dehydrogenase
H4B46_RS16645	COG0824	Thioesterase
H4B46_RS16660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4B46_RS16675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4B46_RS16680	COG2030	dehydratase
H4B46_RS16690	COG0183	Belongs to the thiolase family
H4B46_RS16700	COG0583	DNA-binding transcription factor activity
H4B46_RS16705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4B46_RS16735	COG1522	sequence-specific DNA binding
H4B46_RS16740	COG3135	benzoate transporter
H4B46_RS16750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4B46_RS16775	COG0589	response to stress
H4B46_RS16780	COG0488	(ABC) transporter
H4B46_RS16800	COG4773	Receptor
H4B46_RS16830	COG0668	transmembrane transport
H4B46_RS16840	COG1309	transcriptional regulator
H4B46_RS16855	COG1605	Chorismate mutase
H4B46_RS16895	COG0308	aminopeptidase N
H4B46_RS16915	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H4B46_RS16925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4B46_RS16930	COG1454	alcohol dehydrogenase
H4B46_RS16950	COG0531	amino acid
H4B46_RS16955	COG4303	Ethanolamine ammonia lyase large subunit
H4B46_RS16960	COG4302	ethanolamine ammonia-lyase activity
H4B46_RS16965	COG0519	Catalyzes the synthesis of GMP from XMP
H4B46_RS16965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4B46_RS16970	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H4B46_RS16980	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4B46_RS16995	COG0697	spore germination
H4B46_RS17000	COG1923	regulation of RNA biosynthetic process
H4B46_RS17010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4B46_RS17015	COG0802	atpase or kinase
H4B46_RS17035	COG1187	pseudouridine synthase activity
H4B46_RS17050	COG0583	DNA-binding transcription factor activity
H4B46_RS17065	COG2814	Major facilitator Superfamily
H4B46_RS17070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4B46_RS17095	COG0729	surface antigen
H4B46_RS17115	COG0174	glutamine synthetase
H4B46_RS17120	COG0745	RESPONSE REGULATOR receiver
H4B46_RS17125	COG2205	protein histidine kinase activity
H4B46_RS17135	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4B46_RS17140	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4B46_RS17150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4B46_RS17165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H4B46_RS17170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4B46_RS17175	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS17205	COG0583	DNA-binding transcription factor activity
H4B46_RS17220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4B46_RS17230	COG3658	cytochrome
H4B46_RS17235	COG1215	transferase activity, transferring glycosyl groups
H4B46_RS17240	COG0726	polysaccharide deacetylase
H4B46_RS17240	COG1649	PFAM Uncharacterised BCR, COG1649
H4B46_RS17265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4B46_RS17270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4B46_RS17280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4B46_RS17305	COG0305	Participates in initiation and elongation during chromosome replication
H4B46_RS17310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4B46_RS17320	COG1305	Transglutaminase-like
H4B46_RS17330	COG2308	Evidence 4 Homologs of previously reported genes of
H4B46_RS17360	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H4B46_RS17365	COG0138	bifunctional purine biosynthesis protein purh
H4B46_RS17370	COG0151	Belongs to the GarS family
H4B46_RS17375	COG1464	Belongs to the NlpA lipoprotein family
H4B46_RS17380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4B46_RS17385	COG2011	ABC-type metal ion transport system permease component
H4B46_RS17390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4B46_RS17400	COG1301	dicarboxylic acid transport
H4B46_RS17435	COG1794	racemase activity, acting on amino acids and derivatives
H4B46_RS17445	COG3008	intermembrane lipid transfer
H4B46_RS17445	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4B46_RS17450	COG2995	paraquat-inducible protein a
H4B46_RS17480	COG1051	belongs to the nudix hydrolase family
H4B46_RS17485	COG0477	Major facilitator Superfamily
H4B46_RS17530	COG2186	Transcriptional regulator
H4B46_RS17540	COG0786	glutamate:sodium symporter activity
H4B46_RS17545	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4B46_RS17570	COG3111	PFAM Bacterial OB fold (BOF) protein
H4B46_RS17655	COG2831	hemolysin activation secretion protein
H4B46_RS17680	COG0515	serine threonine protein kinase
H4B46_RS17680	COG2815	serine threonine protein kinase
H4B46_RS17710	COG1610	YqeY-like protein
H4B46_RS17715	COG4783	chaperone-mediated protein folding
H4B46_RS17740	COG1286	toxin biosynthetic process
H4B46_RS17770	COG0778	Nitroreductase
H4B46_RS17780	COG0513	Belongs to the DEAD box helicase family
H4B46_RS17800	COG2363	Small membrane protein
H4B46_RS17830	COG1234	tRNA 3'-trailer cleavage
H4B46_RS17835	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4B46_RS17845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4B46_RS17855	COG2819	hydrolase of the alpha beta superfamily
H4B46_RS17860	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS17865	COG1301	dicarboxylic acid transport
H4B46_RS17870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4B46_RS17875	COG3139	Protein of unknown function (DUF1315)
H4B46_RS17880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4B46_RS17885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4B46_RS17895	COG0494	nUDIX hydrolase
H4B46_RS17905	COG0642	Histidine kinase
H4B46_RS17920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4B46_RS17930	COG1720	tRNA m6t6A37 methyltransferase activity
H4B46_RS17940	COG0384	phenazine biosynthesis protein PhzF
H4B46_RS17945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4B46_RS17950	COG0826	peptidase U32
H4B46_RS17955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4B46_RS17965	COG4598	ABC transporter
H4B46_RS17970	COG4160	amino acid transport
H4B46_RS17975	COG4215	(ABC) transporter
H4B46_RS17990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4B46_RS18035	COG1131	(ABC) transporter
H4B46_RS18040	COG0842	Transport permease protein
H4B46_RS18055	COG0772	Belongs to the SEDS family
H4B46_RS18060	COG2951	lytic endotransglycosylase activity
H4B46_RS18085	COG2207	Transcriptional regulator
H4B46_RS18100	COG0052	Belongs to the universal ribosomal protein uS2 family
H4B46_RS18105	COG0024	Methionine aminopeptidase
H4B46_RS18115	COG2223	nitrite transmembrane transporter activity
H4B46_RS18125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4B46_RS18130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4B46_RS18135	COG1960	acyl-CoA dehydrogenase activity
H4B46_RS18150	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4B46_RS18155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4B46_RS18160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4B46_RS18180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4B46_RS18185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4B46_RS18190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4B46_RS18225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4B46_RS18235	COG0174	glutamine synthetase
H4B46_RS18250	COG0582	viral genome integration into host DNA
H4B46_RS18325	COG0739	heme binding
H4B46_RS18325	COG0741	lytic transglycosylase activity
H4B46_RS18325	COG1196	nuclear chromosome segregation