locus-tag	class	description
FRO58_RS00010	COG0592	DNA-directed DNA polymerase activity
FRO58_RS00020	COG0187	DNA topoisomerase II activity
FRO58_RS00030	COG0586	Pfam SNARE associated Golgi protein
FRO58_RS00035	COG0488	(ABC) transporter
FRO58_RS00060	COG0596	Alpha beta hydrolase
FRO58_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FRO58_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FRO58_RS00110	COG0733	neurotransmitter:sodium symporter activity
FRO58_RS00150	COG2233	PERMEase
FRO58_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS00200	COG2814	Major facilitator Superfamily
FRO58_RS00205	COG0656	L-ascorbic acid biosynthetic process
FRO58_RS00210	COG0583	DNA-binding transcription factor activity
FRO58_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRO58_RS00230	COG1064	alcohol dehydrogenase
FRO58_RS00235	COG2818	Glycosylase
FRO58_RS00250	COG1194	a g-specific adenine glycosylase
FRO58_RS00270	COG2983	Belongs to the UPF0260 family
FRO58_RS00275	COG2133	pyrroloquinoline quinone binding
FRO58_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FRO58_RS00285	COG2116	formate transmembrane transporter activity
FRO58_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRO58_RS00310	COG1335	isochorismatase
FRO58_RS00315	COG0385	Bile acid
FRO58_RS00320	COG0534	Mate efflux family protein
FRO58_RS00325	COG1683	Conserved Protein
FRO58_RS00345	COG0625	glutathione transferase activity
FRO58_RS00355	COG1113	amino acid transport
FRO58_RS00365	COG0523	cobalamin synthesis protein
FRO58_RS00375	COG2188	Transcriptional regulator
FRO58_RS00405	COG0010	Belongs to the arginase family
FRO58_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRO58_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FRO58_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FRO58_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FRO58_RS00540	COG0534	Mate efflux family protein
FRO58_RS00545	COG0436	Aminotransferase
FRO58_RS00550	COG2733	membrane
FRO58_RS00565	COG2918	glutathione biosynthetic process
FRO58_RS00580	COG1388	LysM domain
FRO58_RS00580	COG0791	NLP P60 protein
FRO58_RS00595	COG3150	esterase
FRO58_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FRO58_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRO58_RS00630	COG2233	PERMEase
FRO58_RS00635	COG2351	hydroxyisourate hydrolase activity
FRO58_RS00670	COG3706	GGDEF domain
FRO58_RS00685	COG1393	Belongs to the ArsC family
FRO58_RS00690	COG0708	Exodeoxyribonuclease III
FRO58_RS00710	COG0189	ligase activity
FRO58_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FRO58_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FRO58_RS00755	COG4942	peptidase
FRO58_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRO58_RS00775	COG2119	membrane
FRO58_RS00780	COG4774	siderophore transport
FRO58_RS00785	COG0426	domain, Protein
FRO58_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRO58_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FRO58_RS00830	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS00835	COG1519	Transferase
FRO58_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRO58_RS00845	COG0668	transmembrane transport
FRO58_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRO58_RS00860	COG1335	isochorismatase
FRO58_RS00865	COG1522	sequence-specific DNA binding
FRO58_RS00870	COG3328	transposase activity
FRO58_RS00895	COG2205	protein histidine kinase activity
FRO58_RS00895	COG2198	Histidine kinase
FRO58_RS00895	COG0784	Response regulator, receiver
FRO58_RS00900	COG3162	membrane
FRO58_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRO58_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRO58_RS00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FRO58_RS00940	COG1309	transcriptional regulator
FRO58_RS00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRO58_RS00960	COG0352	thiamine-phosphate diphosphorylase activity
FRO58_RS00960	COG0351	phosphomethylpyrimidine kinase
FRO58_RS00970	COG2814	Major facilitator Superfamily
FRO58_RS00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRO58_RS00995	COG1113	amino acid transport
FRO58_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRO58_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS01020	COG1335	isochorismatase
FRO58_RS01050	COG2814	Major facilitator Superfamily
FRO58_RS01055	COG0583	DNA-binding transcription factor activity
FRO58_RS01075	COG0667	Aldo Keto reductase
FRO58_RS01105	COG1733	regulation of RNA biosynthetic process
FRO58_RS01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRO58_RS01175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FRO58_RS01190	COG2329	Antibiotic biosynthesis monooxygenase
FRO58_RS01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FRO58_RS01250	COG0427	acetyl-CoA hydrolase
FRO58_RS01275	COG0659	secondary active sulfate transmembrane transporter activity
FRO58_RS01280	COG4221	oxidoreductase activity
FRO58_RS01285	COG2873	o-acetylhomoserine
FRO58_RS01290	COG0488	(ABC) transporter
FRO58_RS01375	COG0833	amino acid
FRO58_RS01420	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FRO58_RS01425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FRO58_RS01440	COG2226	methyltransferase
FRO58_RS01490	COG0070	glutamate synthase
FRO58_RS01490	COG0067	glutamate synthase
FRO58_RS01490	COG0069	glutamate synthase activity
FRO58_RS01495	COG0493	'glutamate synthase
FRO58_RS01505	COG1704	LemA family
FRO58_RS01510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FRO58_RS01530	COG3307	-O-antigen
FRO58_RS01550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRO58_RS01565	COG0194	GDP metabolic process
FRO58_RS01615	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FRO58_RS01635	COG5380	lipid catabolic process
FRO58_RS01640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FRO58_RS01665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FRO58_RS01670	COG0277	FAD linked oxidase domain protein
FRO58_RS01680	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FRO58_RS01685	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRO58_RS01700	COG1289	transmembrane transporter activity
FRO58_RS01710	COG0628	permease
FRO58_RS01715	COG1192	Involved in chromosome partitioning
FRO58_RS01745	COG0833	amino acid
FRO58_RS01750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRO58_RS01755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRO58_RS01765	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS01805	COG0583	DNA-binding transcription factor activity
FRO58_RS01850	COG0517	IMP dehydrogenase activity
FRO58_RS01855	COG1983	PspC domain protein
FRO58_RS01865	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS01880	COG0408	coproporphyrinogen oxidase activity
FRO58_RS01900	COG0513	Belongs to the DEAD box helicase family
FRO58_RS01910	COG1127	ABC transporter
FRO58_RS01915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FRO58_RS01925	COG2854	intermembrane phospholipid transfer
FRO58_RS01935	COG0598	Magnesium transport protein CorA
FRO58_RS01945	COG0494	nUDIX hydrolase
FRO58_RS01950	COG1040	competence protein
FRO58_RS01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FRO58_RS01975	COG1946	Acyl-CoA thioesterase
FRO58_RS01980	COG1301	dicarboxylic acid transport
FRO58_RS01995	COG1959	2 iron, 2 sulfur cluster binding
FRO58_RS02000	COG1017	nitric oxide dioxygenase activity
FRO58_RS02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRO58_RS02005	COG0433	COG0433 Predicted ATPase
FRO58_RS02010	COG0626	cystathionine gamma-synthase activity
FRO58_RS02165	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FRO58_RS02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FRO58_RS02205	COG0339	signal peptide processing
FRO58_RS02210	COG0557	exoribonuclease II activity
FRO58_RS02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
FRO58_RS02260	COG2169	Transcriptional regulator
FRO58_RS02265	COG0697	spore germination
FRO58_RS02270	COG1295	ribonuclease BN
FRO58_RS02305	COG1702	phosphate starvation-inducible protein PhoH
FRO58_RS02315	COG1196	nuclear chromosome segregation
FRO58_RS02315	COG0739	heme binding
FRO58_RS02315	COG0741	lytic transglycosylase activity
FRO58_RS02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FRO58_RS02355	COG1183	phosphatidylcholine synthase activity
FRO58_RS02400	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS02405	COG1309	transcriptional regulator
FRO58_RS02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRO58_RS02425	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS02445	COG2969	positive regulation of protein catabolic process
FRO58_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FRO58_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FRO58_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FRO58_RS02640	COG5410	chromosome segregation
FRO58_RS02680	COG4607	ABC-type enterochelin transport system periplasmic component
FRO58_RS02685	COG4604	ABC transporter, ATP-binding protein
FRO58_RS02690	COG4605	iron ion homeostasis
FRO58_RS02695	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRO58_RS02700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRO58_RS02715	COG2964	Protein conserved in bacteria
FRO58_RS02725	COG1741	Belongs to the pirin family
FRO58_RS02745	COG1309	transcriptional regulator
FRO58_RS02755	COG4948	Mandelate Racemase Muconate Lactonizing
FRO58_RS02760	COG2814	Major facilitator Superfamily
FRO58_RS02795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FRO58_RS02795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRO58_RS02800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRO58_RS02805	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS02815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRO58_RS02820	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRO58_RS02825	COG0583	DNA-binding transcription factor activity
FRO58_RS02830	COG1113	amino acid transport
FRO58_RS02850	COG2508	Transcriptional regulator
FRO58_RS02850	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FRO58_RS02880	COG2879	small protein
FRO58_RS02885	COG1966	Carbon starvation protein
FRO58_RS02930	COG1067	ATP-dependent peptidase activity
FRO58_RS02935	COG0583	DNA-binding transcription factor activity
FRO58_RS02960	COG1686	Belongs to the peptidase S11 family
FRO58_RS02965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FRO58_RS03000	COG0616	signal peptide processing
FRO58_RS03005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FRO58_RS03015	COG0573	inorganic phosphate transmembrane transporter activity
FRO58_RS03020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FRO58_RS03025	COG1113	amino acid transport
FRO58_RS03030	COG3961	Belongs to the TPP enzyme family
FRO58_RS03035	COG1522	sequence-specific DNA binding
FRO58_RS03045	COG0076	glutamate decarboxylase activity
FRO58_RS03050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FRO58_RS03060	COG1309	transcriptional regulator
FRO58_RS03075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRO58_RS03110	COG0352	thiamine-phosphate diphosphorylase activity
FRO58_RS03135	COG0612	Peptidase, M16
FRO58_RS03145	COG1823	symporter activity
FRO58_RS03150	COG0583	DNA-binding transcription factor activity
FRO58_RS03155	COG0477	Major facilitator Superfamily
FRO58_RS03180	COG1187	pseudouridine synthase activity
FRO58_RS03195	COG1686	Belongs to the peptidase S11 family
FRO58_RS03200	COG1252	NADH dehydrogenase
FRO58_RS03210	COG0415	Belongs to the DNA photolyase family
FRO58_RS03225	COG1215	transferase activity, transferring glycosyl groups
FRO58_RS03255	COG2070	2-Nitropropane dioxygenase
FRO58_RS03440	COG5410	chromosome segregation
FRO58_RS03640	COG0556	nucleotide-excision repair
FRO58_RS03660	COG0436	Aminotransferase
FRO58_RS03690	COG4221	oxidoreductase activity
FRO58_RS03700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FRO58_RS03705	COG1381	Involved in DNA repair and RecF pathway recombination
FRO58_RS03715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FRO58_RS03730	COG0681	Belongs to the peptidase S26 family
FRO58_RS03745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRO58_RS03765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FRO58_RS03770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FRO58_RS03775	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FRO58_RS03785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FRO58_RS03790	COG4208	sulfate ABC transporter
FRO58_RS03795	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FRO58_RS03800	COG0583	DNA-binding transcription factor activity
FRO58_RS03805	COG4625	pathogenesis
FRO58_RS03820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FRO58_RS03835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FRO58_RS03845	COG1056	cytidyltransferase-related domain
FRO58_RS03845	COG1051	belongs to the nudix hydrolase family
FRO58_RS03850	COG1024	Enoyl-CoA hydratase
FRO58_RS03860	COG2814	Major facilitator Superfamily
FRO58_RS03865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FRO58_RS03865	COG0047	phosphoribosylformylglycinamidine synthase activity
FRO58_RS03885	COG1473	amidohydrolase
FRO58_RS03890	COG0824	Thioesterase
FRO58_RS03910	COG0823	Involved in the tonB-independent uptake of proteins
FRO58_RS03930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRO58_RS03965	COG0628	permease
FRO58_RS03975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FRO58_RS03980	COG0596	Alpha beta hydrolase
FRO58_RS03985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FRO58_RS03985	COG0616	signal peptide processing
FRO58_RS03995	COG2333	competence protein COMEC
FRO58_RS03995	COG0658	competence protein
FRO58_RS04000	COG1136	(ABC) transporter
FRO58_RS04005	COG4591	ABC-type transport system involved in lipoprotein release permease component
FRO58_RS04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS04060	COG0463	Glycosyl transferase, family 2
FRO58_RS04090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRO58_RS04095	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS04105	COG0019	diaminopimelate decarboxylase activity
FRO58_RS04115	COG1113	amino acid transport
FRO58_RS04130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FRO58_RS04140	COG3339	Conserved Protein
FRO58_RS04145	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FRO58_RS04150	COG0243	molybdopterin cofactor binding
FRO58_RS04155	COG1929	Belongs to the glycerate kinase type-1 family
FRO58_RS04170	COG0778	Nitroreductase
FRO58_RS04195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRO58_RS04210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FRO58_RS04230	COG0741	lytic transglycosylase activity
FRO58_RS04250	COG0584	glycerophosphoryl diester phosphodiesterase
FRO58_RS04255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRO58_RS04280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRO58_RS04285	COG1597	lipid kinase activity
FRO58_RS04300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FRO58_RS04305	COG0477	Major facilitator Superfamily
FRO58_RS04355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FRO58_RS04360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRO58_RS04385	COG0505	Belongs to the CarA family
FRO58_RS04405	COG0589	response to stress
FRO58_RS04420	COG2843	Capsule synthesis protein
FRO58_RS04455	COG2321	neutral zinc metallopeptidase
FRO58_RS04460	COG2354	Protein conserved in bacteria
FRO58_RS04480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRO58_RS04505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FRO58_RS04510	COG1053	succinate dehydrogenase
FRO58_RS04515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FRO58_RS04520	COG2009	succinate dehydrogenase
FRO58_RS04565	COG2921	Belongs to the UPF0250 family
FRO58_RS04570	COG0321	lipoyl(octanoyl) transferase activity
FRO58_RS04585	COG0531	amino acid
FRO58_RS04595	COG1733	regulation of RNA biosynthetic process
FRO58_RS04600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FRO58_RS04605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FRO58_RS04605	COG1648	precorrin-2 dehydrogenase activity
FRO58_RS04620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FRO58_RS04650	COG0671	phosphoesterase, PA-phosphatase related
FRO58_RS04655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS04665	COG1538	Outer membrane efflux protein
FRO58_RS04670	COG0393	Putative heavy-metal-binding
FRO58_RS04675	COG0393	Putative heavy-metal-binding
FRO58_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS04695	COG0525	valine-tRNA ligase activity
FRO58_RS04715	COG0583	DNA-binding transcription factor activity
FRO58_RS04720	COG0004	ammonium transporteR
FRO58_RS04730	COG0642	Histidine kinase
FRO58_RS04735	COG0745	RESPONSE REGULATOR receiver
FRO58_RS04740	COG2194	sulfuric ester hydrolase activity
FRO58_RS04760	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRO58_RS04775	COG2315	Protein conserved in bacteria
FRO58_RS04780	COG0142	geranyltranstransferase activity
FRO58_RS04785	COG2828	Protein conserved in bacteria
FRO58_RS04790	COG1113	amino acid transport
FRO58_RS04810	COG2207	Transcriptional regulator
FRO58_RS04835	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRO58_RS04845	COG0560	Phosphoserine phosphatase
FRO58_RS04855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRO58_RS04865	COG1530	ribonuclease E activity
FRO58_RS04870	COG0424	maF-like protein
FRO58_RS04875	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FRO58_RS04880	COG1792	Involved in formation and maintenance of cell shape
FRO58_RS04885	COG1077	Cell shape determining protein MreB Mrl
FRO58_RS04890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRO58_RS04900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FRO58_RS04930	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FRO58_RS04935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRO58_RS04940	COG1752	Esterase of the alpha-beta hydrolase superfamily
FRO58_RS04945	COG1115	amino acid carrier protein
FRO58_RS04965	COG2814	Major facilitator Superfamily
FRO58_RS04970	COG1289	transmembrane transporter activity
FRO58_RS04980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FRO58_RS05020	COG1376	ErfK ybiS ycfS ynhG family protein
FRO58_RS05025	COG2832	Protein of unknown function (DUF454)
FRO58_RS05035	COG5510	response to toxic substance
FRO58_RS05055	COG0840	transmembrane signaling receptor activity
FRO58_RS05100	COG3422	double-strand break repair
FRO58_RS05105	COG2824	Alkylphosphonate utilization operon protein PhnA
FRO58_RS05110	COG3189	MarR family transcriptional regulator
FRO58_RS05120	COG0354	folic acid binding
FRO58_RS05125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRO58_RS05140	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS05145	COG4772	TonB-dependent receptor
FRO58_RS05150	COG2094	Belongs to the DNA glycosylase MPG family
FRO58_RS05175	COG1217	gtp-binding protein TYPA
FRO58_RS05180	COG2233	PERMEase
FRO58_RS05190	COG0833	amino acid
FRO58_RS05195	COG1690	Belongs to the RtcB family
FRO58_RS05205	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FRO58_RS05205	COG2885	chlorophyll binding
FRO58_RS05215	COG0183	Belongs to the thiolase family
FRO58_RS05240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRO58_RS05260	COG2207	Transcriptional regulator
FRO58_RS05265	COG0183	Belongs to the thiolase family
FRO58_RS05295	COG1272	protein, Hemolysin III
FRO58_RS05300	COG0477	Major facilitator Superfamily
FRO58_RS05315	COG0450	alkyl hydroperoxide reductase
FRO58_RS05335	COG0285	dihydrofolate synthase activity
FRO58_RS05385	COG2096	Adenosyltransferase
FRO58_RS05405	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FRO58_RS05410	COG0745	RESPONSE REGULATOR receiver
FRO58_RS05415	COG2205	protein histidine kinase activity
FRO58_RS05425	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS05430	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS05435	COG0583	DNA-binding transcription factor activity
FRO58_RS05440	COG0625	glutathione transferase activity
FRO58_RS05505	COG0438	transferase activity, transferring glycosyl groups
FRO58_RS05510	COG0463	Glycosyl transferase, family 2
FRO58_RS05515	COG0726	polysaccharide deacetylase
FRO58_RS05535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FRO58_RS05540	COG2205	protein histidine kinase activity
FRO58_RS05585	COG1862	Preprotein translocase
FRO58_RS05595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FRO58_RS05600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FRO58_RS05610	COG3781	membrane
FRO58_RS05615	COG0613	PHP domain protein
FRO58_RS05625	COG2350	Protein conserved in bacteria
FRO58_RS05655	COG1607	acyl-coa hydrolase
FRO58_RS05715	COG2199	diguanylate cyclase activity
FRO58_RS05725	COG1408	metallophosphoesterase
FRO58_RS05730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRO58_RS05740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FRO58_RS05850	COG0739	heme binding
FRO58_RS05850	COG0741	lytic transglycosylase activity
FRO58_RS05850	COG1196	nuclear chromosome segregation
FRO58_RS05865	COG1598	PFAM Uncharacterised protein family UPF0150
FRO58_RS05970	COG5410	chromosome segregation
FRO58_RS06145	COG0512	Glutamine amidotransferase of anthranilate synthase
FRO58_RS06200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FRO58_RS06210	COG0302	gtp cyclohydrolase
FRO58_RS06235	COG3739	integral membrane protein
FRO58_RS06250	COG1169	isochorismate synthase
FRO58_RS06260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FRO58_RS06265	COG1132	(ABC) transporter
FRO58_RS06270	COG1132	(ABC) transporter
FRO58_RS06285	COG3433	isochorismatase activity
FRO58_RS06285	COG1535	isochorismatase
FRO58_RS06290	COG1021	2,3-dihydroxybenzoate-AMP ligase
FRO58_RS06295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FRO58_RS06305	COG4774	siderophore transport
FRO58_RS06310	COG4607	ABC-type enterochelin transport system periplasmic component
FRO58_RS06315	COG4604	ABC transporter, ATP-binding protein
FRO58_RS06390	COG1598	PFAM Uncharacterised protein family UPF0150
FRO58_RS06485	COG0582	viral genome integration into host DNA
FRO58_RS06500	COG0174	glutamine synthetase
FRO58_RS06510	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FRO58_RS06545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FRO58_RS06550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FRO58_RS06555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FRO58_RS06575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FRO58_RS06580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FRO58_RS06585	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FRO58_RS06600	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS06605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRO58_RS06610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRO58_RS06620	COG2223	nitrite transmembrane transporter activity
FRO58_RS06630	COG0024	Methionine aminopeptidase
FRO58_RS06635	COG0052	Belongs to the universal ribosomal protein uS2 family
FRO58_RS06650	COG2207	Transcriptional regulator
FRO58_RS06675	COG2951	lytic endotransglycosylase activity
FRO58_RS06680	COG0772	Belongs to the SEDS family
FRO58_RS06695	COG0842	Transport permease protein
FRO58_RS06700	COG1131	(ABC) transporter
FRO58_RS06745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS06760	COG4215	(ABC) transporter
FRO58_RS06765	COG4160	amino acid transport
FRO58_RS06770	COG4598	ABC transporter
FRO58_RS06780	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRO58_RS06785	COG0826	peptidase U32
FRO58_RS06790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRO58_RS06805	COG1720	tRNA m6t6A37 methyltransferase activity
FRO58_RS06815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FRO58_RS06830	COG0642	Histidine kinase
FRO58_RS06840	COG0494	nUDIX hydrolase
FRO58_RS06850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FRO58_RS06855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FRO58_RS06860	COG3139	Protein of unknown function (DUF1315)
FRO58_RS06865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FRO58_RS06870	COG1301	dicarboxylic acid transport
FRO58_RS06875	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS06880	COG2819	hydrolase of the alpha beta superfamily
FRO58_RS06890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FRO58_RS06900	COG2195	Cleaves the N-terminal amino acid of tripeptides
FRO58_RS06905	COG1234	tRNA 3'-trailer cleavage
FRO58_RS06935	COG2363	Small membrane protein
FRO58_RS06955	COG0513	Belongs to the DEAD box helicase family
FRO58_RS06965	COG0778	Nitroreductase
FRO58_RS06995	COG1286	toxin biosynthetic process
FRO58_RS07020	COG4783	chaperone-mediated protein folding
FRO58_RS07025	COG1610	YqeY-like protein
FRO58_RS07125	COG3111	PFAM Bacterial OB fold (BOF) protein
FRO58_RS07155	COG3243	poly(R)-hydroxyalkanoic acid synthase
FRO58_RS07160	COG0786	glutamate:sodium symporter activity
FRO58_RS07170	COG2186	Transcriptional regulator
FRO58_RS07220	COG0477	Major facilitator Superfamily
FRO58_RS07245	COG2985	domain, Protein
FRO58_RS07255	COG2995	paraquat-inducible protein a
FRO58_RS07260	COG3008	intermembrane lipid transfer
FRO58_RS07260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FRO58_RS07270	COG1794	racemase activity, acting on amino acids and derivatives
FRO58_RS07300	COG1301	dicarboxylic acid transport
FRO58_RS07310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRO58_RS07315	COG2011	ABC-type metal ion transport system permease component
FRO58_RS07320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRO58_RS07325	COG1464	Belongs to the NlpA lipoprotein family
FRO58_RS07330	COG0151	Belongs to the GarS family
FRO58_RS07335	COG0138	bifunctional purine biosynthesis protein purh
FRO58_RS07340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FRO58_RS07370	COG2308	Evidence 4 Homologs of previously reported genes of
FRO58_RS07380	COG1305	Transglutaminase-like
FRO58_RS07390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FRO58_RS07395	COG0305	Participates in initiation and elongation during chromosome replication
FRO58_RS07420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FRO58_RS07430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FRO58_RS07435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FRO58_RS07460	COG1649	PFAM Uncharacterised BCR, COG1649
FRO58_RS07460	COG0726	polysaccharide deacetylase
FRO58_RS07465	COG1215	transferase activity, transferring glycosyl groups
FRO58_RS07470	COG3658	cytochrome
FRO58_RS07480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRO58_RS07495	COG0583	DNA-binding transcription factor activity
FRO58_RS07515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRO58_RS07520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRO58_RS07535	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS07540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRO58_RS07545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRO58_RS07570	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FRO58_RS07575	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FRO58_RS07585	COG2205	protein histidine kinase activity
FRO58_RS07590	COG0745	RESPONSE REGULATOR receiver
FRO58_RS07595	COG0174	glutamine synthetase
FRO58_RS07615	COG0729	surface antigen
FRO58_RS07640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRO58_RS07645	COG2814	Major facilitator Superfamily
FRO58_RS07660	COG0583	DNA-binding transcription factor activity
FRO58_RS07675	COG1187	pseudouridine synthase activity
FRO58_RS07695	COG0802	atpase or kinase
FRO58_RS07700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FRO58_RS07710	COG1923	regulation of RNA biosynthetic process
FRO58_RS07715	COG0697	spore germination
FRO58_RS07730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRO58_RS07740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRO58_RS07745	COG0519	Catalyzes the synthesis of GMP from XMP
FRO58_RS07745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRO58_RS07750	COG4302	ethanolamine ammonia-lyase activity
FRO58_RS07755	COG4303	Ethanolamine ammonia lyase large subunit
FRO58_RS07760	COG0531	amino acid
FRO58_RS07780	COG1454	alcohol dehydrogenase
FRO58_RS07785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRO58_RS07795	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FRO58_RS07815	COG0308	aminopeptidase N
FRO58_RS07825	COG4221	oxidoreductase activity
FRO58_RS07835	COG1605	Chorismate mutase
FRO58_RS07850	COG1309	transcriptional regulator
FRO58_RS07860	COG0668	transmembrane transport
FRO58_RS07890	COG4773	Receptor
FRO58_RS07910	COG0488	(ABC) transporter
FRO58_RS07915	COG0589	response to stress
FRO58_RS07940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FRO58_RS07950	COG3135	benzoate transporter
FRO58_RS07955	COG1522	sequence-specific DNA binding
FRO58_RS07965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FRO58_RS07970	COG0583	DNA-binding transcription factor activity
FRO58_RS07980	COG0183	Belongs to the thiolase family
FRO58_RS07990	COG2030	dehydratase
FRO58_RS07995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRO58_RS08010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FRO58_RS08020	COG0824	Thioesterase
FRO58_RS08025	COG1454	alcohol dehydrogenase
FRO58_RS08035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FRO58_RS08055	COG0069	glutamate synthase activity
FRO58_RS08385	COG2814	Major facilitator Superfamily
FRO58_RS08400	COG0511	ligase activity, forming carbon-carbon bonds
FRO58_RS08420	COG1116	anion transmembrane transporter activity
FRO58_RS08420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRO58_RS08425	COG0745	RESPONSE REGULATOR receiver
FRO58_RS08435	COG2146	nitrite reductase [NAD(P)H] activity
FRO58_RS08435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRO58_RS08440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRO58_RS08445	COG0243	molybdopterin cofactor binding
FRO58_RS08455	COG0243	molybdopterin cofactor binding
FRO58_RS08460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FRO58_RS08475	COG0521	Mo-molybdopterin cofactor biosynthetic process
FRO58_RS08475	COG0315	cyclic pyranopterin monophosphate synthase activity
FRO58_RS08480	COG0303	'Molybdopterin
FRO58_RS08490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRO58_RS08495	COG0697	spore germination
FRO58_RS08515	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FRO58_RS08520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRO58_RS08575	COG2204	response regulator
FRO58_RS08580	COG3852	Histidine kinase
FRO58_RS08600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FRO58_RS08605	COG0575	Belongs to the CDS family
FRO58_RS08640	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRO58_RS08655	COG2137	regulation of response to DNA damage stimulus
FRO58_RS08665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FRO58_RS08670	COG1011	Hydrolase
FRO58_RS08695	COG1522	sequence-specific DNA binding
FRO58_RS08705	COG1113	amino acid transport
FRO58_RS08720	COG0659	secondary active sulfate transmembrane transporter activity
FRO58_RS08725	COG2135	peptidase activity
FRO58_RS08740	COG3300	MHYT domain
FRO58_RS08740	COG5001	Diguanylate cyclase
FRO58_RS08760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FRO58_RS08760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRO58_RS08760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FRO58_RS08765	COG1105	Belongs to the carbohydrate kinase PfkB family
FRO58_RS08770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRO58_RS08770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FRO58_RS08800	COG0024	Methionine aminopeptidase
FRO58_RS08805	COG0583	DNA-binding transcription factor activity
FRO58_RS08815	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FRO58_RS08820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FRO58_RS08825	COG0516	GMP reductase activity
FRO58_RS08825	COG0517	IMP dehydrogenase activity
FRO58_RS08850	COG0552	protein localization to endoplasmic reticulum
FRO58_RS08860	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FRO58_RS08875	COG4890	Cyd operon protein YbgT
FRO58_RS08880	COG1294	oxidase, subunit
FRO58_RS08900	COG1585	Membrane protein implicated in regulation of membrane protease activity
FRO58_RS08910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FRO58_RS08915	COG4774	siderophore transport
FRO58_RS08930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FRO58_RS08935	COG0569	domain protein
FRO58_RS08940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FRO58_RS08970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FRO58_RS08975	COG0542	response to heat
FRO58_RS09000	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRO58_RS09000	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS09045	COG2323	membrane
FRO58_RS09050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FRO58_RS09060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRO58_RS09065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRO58_RS09070	COG0183	Belongs to the thiolase family
FRO58_RS09075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FRO58_RS09080	COG0596	Alpha beta hydrolase
FRO58_RS09085	COG2271	Major facilitator Superfamily
FRO58_RS09090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRO58_RS09095	COG3485	protocatechuate 3,4-dioxygenase
FRO58_RS09100	COG3485	protocatechuate 3,4-dioxygenase
FRO58_RS09105	COG0710	3-dehydroquinate dehydratase activity
FRO58_RS09110	COG3420	alginic acid biosynthetic process
FRO58_RS09115	COG3659	wide pore channel activity
FRO58_RS09120	COG4993	Dehydrogenase
FRO58_RS09130	COG2391	methyltransferase activity
FRO58_RS09145	COG1414	Transcriptional regulator
FRO58_RS09150	COG0583	DNA-binding transcription factor activity
FRO58_RS09155	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS09180	COG2814	Major facilitator Superfamily
FRO58_RS09190	COG0154	amidase activity
FRO58_RS09210	COG4638	Rieske (2fe-2S)
FRO58_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS09230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRO58_RS09240	COG3733	amine oxidase
FRO58_RS09250	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS09260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRO58_RS09265	COG0183	Belongs to the thiolase family
FRO58_RS09270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRO58_RS09275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRO58_RS09285	COG4829	muconolactone delta-isomerase
FRO58_RS09290	COG4948	Mandelate Racemase Muconate Lactonizing
FRO58_RS09295	COG0583	DNA-binding transcription factor activity
FRO58_RS09305	COG2186	Transcriptional regulator
FRO58_RS09325	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS09345	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS09355	COG3829	transcription factor binding
FRO58_RS09365	COG3162	membrane
FRO58_RS09380	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS09395	COG0753	catalase activity
FRO58_RS09415	COG1846	Transcriptional regulator
FRO58_RS09420	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRO58_RS09420	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS09430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FRO58_RS09460	COG1309	transcriptional regulator
FRO58_RS09470	COG1335	isochorismatase
FRO58_RS09475	COG0583	DNA-binding transcription factor activity
FRO58_RS09485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRO58_RS09485	COG0475	glutathione-regulated potassium exporter activity
FRO58_RS09495	COG1473	amidohydrolase
FRO58_RS09505	COG2831	hemolysin activation secretion protein
FRO58_RS09510	COG3210	domain, Protein
FRO58_RS09540	COG2188	Transcriptional regulator
FRO58_RS09555	COG0583	DNA-binding transcription factor activity
FRO58_RS09585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FRO58_RS09605	COG1566	PFAM secretion protein HlyD family protein
FRO58_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS09625	COG0129	dihydroxy-acid dehydratase activity
FRO58_RS09635	COG0583	DNA-binding transcription factor activity
FRO58_RS09640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FRO58_RS09650	COG2084	Dehydrogenase
FRO58_RS09655	COG2207	Transcriptional regulator
FRO58_RS09670	COG1064	alcohol dehydrogenase
FRO58_RS09680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FRO58_RS09710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRO58_RS09825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FRO58_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS09890	COG2207	Transcriptional regulator
FRO58_RS09900	COG2205	protein histidine kinase activity
FRO58_RS09905	COG0745	RESPONSE REGULATOR receiver
FRO58_RS09910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS09915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRO58_RS09920	COG1538	Outer membrane efflux protein
FRO58_RS09930	COG2072	flavoprotein involved in K transport
FRO58_RS09950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRO58_RS09970	COG3539	Fimbrial protein
FRO58_RS10000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FRO58_RS10010	COG0753	catalase activity
FRO58_RS10025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FRO58_RS10085	COG3433	isochorismatase activity
FRO58_RS10085	COG1535	isochorismatase
FRO58_RS10090	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS10095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FRO58_RS10100	COG4149	molybdate abc transporter
FRO58_RS10105	COG0725	ABC transporter, periplasmic molybdate-binding protein
FRO58_RS10115	COG4638	Rieske (2fe-2S)
FRO58_RS10120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRO58_RS10125	COG0543	2 iron, 2 sulfur cluster binding
FRO58_RS10125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRO58_RS10150	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS10165	COG2207	Transcriptional regulator
FRO58_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS10180	COG2610	gluconate transmembrane transporter activity
FRO58_RS10190	COG0583	DNA-binding transcription factor activity
FRO58_RS10200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRO58_RS10205	COG2031	fatty acid transporter
FRO58_RS10210	COG0183	Belongs to the thiolase family
FRO58_RS10215	COG0583	DNA-binding transcription factor activity
FRO58_RS10220	COG0583	DNA-binding transcription factor activity
FRO58_RS10235	COG1027	Aspartate ammonia-lyase
FRO58_RS10245	COG0477	Major facilitator Superfamily
FRO58_RS10265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRO58_RS10270	COG4521	taurine ABC transporter
FRO58_RS10285	COG2188	Transcriptional regulator
FRO58_RS10295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FRO58_RS10300	COG1733	regulation of RNA biosynthetic process
FRO58_RS10305	COG2207	Transcriptional regulator
FRO58_RS10305	COG3708	Transcriptional regulator
FRO58_RS10320	COG0730	response to heat
FRO58_RS10330	COG3453	Protein conserved in bacteria
FRO58_RS10330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRO58_RS10340	COG3781	membrane
FRO58_RS10345	COG1063	alcohol dehydrogenase
FRO58_RS10355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FRO58_RS10360	COG0508	dehydrogenase complex catalyzes the overall conversion of
FRO58_RS10365	COG0022	dehydrogenase e1 component
FRO58_RS10370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FRO58_RS10375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FRO58_RS10395	COG3706	GGDEF domain
FRO58_RS10410	COG0133	tryptophan synthase activity
FRO58_RS10420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FRO58_RS10455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FRO58_RS10480	COG2226	methyltransferase
FRO58_RS10535	COG0842	Transport permease protein
FRO58_RS10540	COG0842	Transport permease protein
FRO58_RS10545	COG1131	(ABC) transporter
FRO58_RS10560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FRO58_RS10565	COG4773	Receptor
FRO58_RS10585	COG0730	response to heat
FRO58_RS10590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FRO58_RS10610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FRO58_RS10625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRO58_RS10665	COG4264	IucA IucC family
FRO58_RS10670	COG4264	IucA IucC family
FRO58_RS10690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FRO58_RS10705	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS10710	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS10715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FRO58_RS10720	COG2207	Transcriptional regulator
FRO58_RS10725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRO58_RS10730	COG0776	regulation of translation
FRO58_RS10755	COG0822	iron-sulfur transferase activity
FRO58_RS10760	COG0316	Belongs to the HesB IscA family
FRO58_RS10790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRO58_RS10810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FRO58_RS10815	COG0702	epimerase
FRO58_RS10855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FRO58_RS10865	COG0339	signal peptide processing
FRO58_RS10915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FRO58_RS10920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FRO58_RS10950	COG0776	regulation of translation
FRO58_RS11015	COG0084	hydrolase, TatD family'
FRO58_RS11035	COG1663	tetraacyldisaccharide 4'-kinase activity
FRO58_RS11040	COG1132	(ABC) transporter
FRO58_RS11050	COG0811	peptide transport
FRO58_RS11055	COG1475	DNA binding
FRO58_RS11060	COG1192	Involved in chromosome partitioning
FRO58_RS11070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FRO58_RS11085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FRO58_RS11090	COG0191	fructose-bisphosphate aldolase activity
FRO58_RS11110	COG0424	maF-like protein
FRO58_RS11115	COG2850	peptidyl-arginine hydroxylation
FRO58_RS11125	COG0640	Transcriptional regulator
FRO58_RS11135	COG3619	membrane
FRO58_RS11140	COG3122	Protein conserved in bacteria
FRO58_RS11145	COG1132	(ABC) transporter
FRO58_RS11165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FRO58_RS11170	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FRO58_RS11180	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRO58_RS11180	COG0506	proline dehydrogenase activity
FRO58_RS11180	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FRO58_RS11185	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FRO58_RS11200	COG3698	Phosphodiester glycosidase
FRO58_RS11210	COG2353	YceI-like domain
FRO58_RS11220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FRO58_RS11265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FRO58_RS11265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FRO58_RS11290	COG3539	Fimbrial protein
FRO58_RS11295	COG3121	Chaperone
FRO58_RS11320	COG0697	spore germination
FRO58_RS11330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FRO58_RS11340	COG0583	DNA-binding transcription factor activity
FRO58_RS11360	COG1309	transcriptional regulator
FRO58_RS11375	COG1522	sequence-specific DNA binding
FRO58_RS11385	COG1126	abc transporter atp-binding protein
FRO58_RS11390	COG0765	amino acid transport
FRO58_RS11395	COG0765	amino acid transport
FRO58_RS11425	COG1464	Belongs to the NlpA lipoprotein family
FRO58_RS11435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRO58_RS11440	COG2011	ABC-type metal ion transport system permease component
FRO58_RS11445	COG0012	GTP binding
FRO58_RS11470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FRO58_RS11510	COG0386	Belongs to the glutathione peroxidase family
FRO58_RS11520	COG0436	Aminotransferase
FRO58_RS11560	COG3634	alkyl hydroperoxide reductase activity
FRO58_RS11575	COG0583	DNA-binding transcription factor activity
FRO58_RS11580	COG0798	PFAM Bile acid sodium symporter
FRO58_RS11585	COG0640	Transcriptional regulator
FRO58_RS11600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FRO58_RS11610	COG0583	DNA-binding transcription factor activity
FRO58_RS11620	COG1953	Uracil, thiamine, allantoin
FRO58_RS11630	COG2175	clavaminate synthase activity
FRO58_RS11635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRO58_RS11640	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FRO58_RS11645	COG4521	taurine ABC transporter
FRO58_RS11655	COG0477	Major facilitator Superfamily
FRO58_RS11675	COG1271	oxidase subunit
FRO58_RS11680	COG1294	oxidase, subunit
FRO58_RS11690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRO58_RS11710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FRO58_RS11730	COG3052	prosthetic group binding
FRO58_RS11735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FRO58_RS11745	COG2814	Major facilitator Superfamily
FRO58_RS11765	COG1346	cytolysis
FRO58_RS11775	COG0583	DNA-binding transcription factor activity
FRO58_RS11780	COG0625	glutathione transferase activity
FRO58_RS11785	COG0625	glutathione transferase activity
FRO58_RS11790	COG0583	DNA-binding transcription factor activity
FRO58_RS11805	COG1045	serine acetyltransferase
FRO58_RS11810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FRO58_RS11815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FRO58_RS11825	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS11840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRO58_RS11845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRO58_RS11850	COG1126	abc transporter atp-binding protein
FRO58_RS11855	COG0765	amino acid transport
FRO58_RS11860	COG0765	amino acid transport
FRO58_RS11880	COG2205	protein histidine kinase activity
FRO58_RS11880	COG0784	Response regulator, receiver
FRO58_RS11900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FRO58_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS11970	COG0583	DNA-binding transcription factor activity
FRO58_RS11990	COG0318	PFAM AMP-dependent synthetase and ligase
FRO58_RS11995	COG1309	transcriptional regulator
FRO58_RS12000	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS12005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FRO58_RS12010	COG1024	Enoyl-CoA hydratase
FRO58_RS12015	COG4770	biotin carboxylase activity
FRO58_RS12025	COG0583	DNA-binding transcription factor activity
FRO58_RS12040	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS12050	COG2814	Major facilitator Superfamily
FRO58_RS12060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FRO58_RS12065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FRO58_RS12070	COG2814	Major facilitator Superfamily
FRO58_RS12075	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS12080	COG1024	Enoyl-CoA hydratase
FRO58_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS12090	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRO58_RS12095	COG0183	Belongs to the thiolase family
FRO58_RS12105	COG2814	Major facilitator Superfamily
FRO58_RS12115	COG1024	Enoyl-CoA hydratase
FRO58_RS12130	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS12135	COG2814	Major facilitator Superfamily
FRO58_RS12140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FRO58_RS12145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FRO58_RS12160	COG3842	ATPase activity
FRO58_RS12165	COG1840	ABC-type Fe3 transport system, periplasmic component
FRO58_RS12175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRO58_RS12180	COG1414	Transcriptional regulator
FRO58_RS12190	COG0583	DNA-binding transcription factor activity
FRO58_RS12195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FRO58_RS12200	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS12210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FRO58_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS12225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRO58_RS12230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRO58_RS12235	COG2267	carboxylic ester hydrolase activity
FRO58_RS12255	COG3038	cytochrome b561
FRO58_RS12260	COG0753	catalase activity
FRO58_RS12295	COG2050	protein possibly involved in aromatic compounds catabolism
FRO58_RS12305	COG3327	negative regulation of DNA-templated transcription, initiation
FRO58_RS12310	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FRO58_RS12315	COG0183	Belongs to the thiolase family
FRO58_RS12320	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRO58_RS12325	COG1024	Enoyl-CoA hydratase
FRO58_RS12330	COG1024	Enoyl-CoA hydratase
FRO58_RS12335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FRO58_RS12340	COG2151	metal-sulfur cluster biosynthetic enzyme
FRO58_RS12345	COG3396	Phenylacetate-CoA oxygenase
FRO58_RS12350	COG3460	Phenylacetate-CoA oxygenase
FRO58_RS12355	COG3396	Phenylacetate-CoA oxygenase
FRO58_RS12360	COG2030	dehydratase
FRO58_RS12360	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS12365	COG1760	l-serine dehydratase
FRO58_RS12370	COG0531	amino acid
FRO58_RS12375	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS12390	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRO58_RS12400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FRO58_RS12420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRO58_RS12430	COG0789	Transcriptional regulator
FRO58_RS12445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FRO58_RS12460	COG2807	transmembrane transport
FRO58_RS12465	COG0590	tRNA wobble adenosine to inosine editing
FRO58_RS12580	COG1116	anion transmembrane transporter activity
FRO58_RS12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FRO58_RS12595	COG0864	Transcriptional regulator
FRO58_RS12615	COG2249	NAD(P)H dehydrogenase (quinone) activity
FRO58_RS12620	COG0439	Biotin carboxylase
FRO58_RS12635	COG1063	alcohol dehydrogenase
FRO58_RS12645	COG1309	transcriptional regulator
FRO58_RS12665	COG0038	chloride channel
FRO58_RS12670	COG4770	biotin carboxylase activity
FRO58_RS12690	COG1914	H( )-stimulated, divalent metal cation uptake system
FRO58_RS12695	COG0583	DNA-binding transcription factor activity
FRO58_RS12745	COG1250	3-hydroxyacyl-CoA dehydrogenase
FRO58_RS12765	COG2814	Major facilitator Superfamily
FRO58_RS12775	COG1560	Kdo2-lipid A biosynthetic process
FRO58_RS12785	COG5006	permease, DMT superfamily
FRO58_RS12790	COG1522	sequence-specific DNA binding
FRO58_RS12805	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FRO58_RS12815	COG4122	O-methyltransferase activity
FRO58_RS12845	COG1538	Outer membrane efflux protein
FRO58_RS12850	COG1137	ATPase activity
FRO58_RS12855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FRO58_RS12865	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FRO58_RS12870	COG0517	IMP dehydrogenase activity
FRO58_RS12870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FRO58_RS13120	COG2814	Major facilitator Superfamily
FRO58_RS13155	COG1278	Cold shock
FRO58_RS13160	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS13190	COG1570	exodeoxyribonuclease VII activity
FRO58_RS13240	COG0583	DNA-binding transcription factor activity
FRO58_RS13245	COG4638	Rieske (2fe-2S)
FRO58_RS13250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FRO58_RS13255	COG0543	2 iron, 2 sulfur cluster binding
FRO58_RS13255	COG0633	Ferredoxin
FRO58_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS13265	COG3135	benzoate transporter
FRO58_RS13270	COG2814	Major facilitator Superfamily
FRO58_RS13285	COG1643	Atp-dependent helicase
FRO58_RS13290	COG0450	alkyl hydroperoxide reductase
FRO58_RS13300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FRO58_RS13310	COG3634	alkyl hydroperoxide reductase activity
FRO58_RS13330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FRO58_RS13335	COG0625	glutathione transferase activity
FRO58_RS13345	COG2885	chlorophyll binding
FRO58_RS13380	COG0542	response to heat
FRO58_RS13395	COG1765	OsmC-like protein
FRO58_RS13415	COG0667	Aldo Keto reductase
FRO58_RS13430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FRO58_RS13440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FRO58_RS13450	COG0527	aspartate kinase activity
FRO58_RS13460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FRO58_RS13470	COG3038	cytochrome b561
FRO58_RS13475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FRO58_RS13480	COG2252	PERMEase
FRO58_RS13490	COG2072	flavoprotein involved in K transport
FRO58_RS13505	COG1741	Belongs to the pirin family
FRO58_RS13510	COG1309	transcriptional regulator
FRO58_RS13520	COG0300	oxidoreductase activity
FRO58_RS13635	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FRO58_RS13780	COG4269	membrane
FRO58_RS13795	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRO58_RS13795	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS13805	COG5001	Diguanylate cyclase
FRO58_RS13805	COG4251	negative regulation of phosphorylation
FRO58_RS13805	COG3706	GGDEF domain
FRO58_RS13805	COG2203	Gaf domain
FRO58_RS13815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRO58_RS13835	COG4172	Belongs to the ABC transporter superfamily
FRO58_RS13840	COG4239	(ABC) transporter, permease
FRO58_RS13845	COG4174	ABC transporter (Permease)
FRO58_RS13855	COG0741	lytic transglycosylase activity
FRO58_RS13855	COG1388	LysM domain
FRO58_RS13855	COG0741	lytic transglycosylase activity
FRO58_RS13855	COG1388	LysM domain
FRO58_RS13860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRO58_RS13900	COG0583	DNA-binding transcription factor activity
FRO58_RS13905	COG1279	arginine transmembrane transporter activity
FRO58_RS13925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRO58_RS13930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRO58_RS13935	COG0006	proline dipeptidase activity
FRO58_RS13975	COG2194	sulfuric ester hydrolase activity
FRO58_RS14020	COG0739	heme binding
FRO58_RS14345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FRO58_RS14375	COG3384	dioxygenase
FRO58_RS14385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FRO58_RS14390	COG2878	Part of a membrane complex involved in electron transport
FRO58_RS14395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FRO58_RS14420	COG0768	penicillin binding
FRO58_RS14425	COG0742	ribosomal rna small subunit methyltransferase
FRO58_RS14440	COG0830	nickel cation binding
FRO58_RS14490	COG1253	flavin adenine dinucleotide binding
FRO58_RS14495	COG2851	Citrate transporter
FRO58_RS14545	COG1773	rubredoxin
FRO58_RS14550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FRO58_RS14560	COG0583	DNA-binding transcription factor activity
FRO58_RS14585	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FRO58_RS14590	COG4181	ATPase activity
FRO58_RS14635	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FRO58_RS14655	COG0306	phosphate transporter
FRO58_RS14665	COG3958	Transketolase
FRO58_RS14670	COG3959	Transketolase, thiamine diphosphate binding domain
FRO58_RS14675	COG2271	Major facilitator Superfamily
FRO58_RS14680	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS14685	COG0583	DNA-binding transcription factor activity
FRO58_RS14700	COG2223	nitrite transmembrane transporter activity
FRO58_RS14705	COG2207	Transcriptional regulator
FRO58_RS14710	COG2066	Belongs to the glutaminase family
FRO58_RS14715	COG0242	peptide deformylase activity
FRO58_RS14720	COG0477	Major facilitator Superfamily
FRO58_RS14730	COG0028	Belongs to the TPP enzyme family
FRO58_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS14750	COG2267	carboxylic ester hydrolase activity
FRO58_RS14760	COG2271	Major facilitator Superfamily
FRO58_RS14765	COG0446	pyridine nucleotide-disulphide oxidoreductase
FRO58_RS14775	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS14795	COG1414	Transcriptional regulator
FRO58_RS14810	COG1024	Enoyl-CoA hydratase
FRO58_RS14820	COG1215	transferase activity, transferring glycosyl groups
FRO58_RS14825	COG1649	PFAM Uncharacterised BCR, COG1649
FRO58_RS14825	COG0726	polysaccharide deacetylase
FRO58_RS14835	COG4681	YaeQ
FRO58_RS14845	COG0523	cobalamin synthesis protein
FRO58_RS14855	COG1607	acyl-coa hydrolase
FRO58_RS14865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRO58_RS14870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FRO58_RS14875	COG1309	transcriptional regulator
FRO58_RS14900	COG2040	homocysteine
FRO58_RS14905	COG0531	amino acid
FRO58_RS14930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRO58_RS14935	COG0477	Major facilitator Superfamily
FRO58_RS14975	COG0405	Gamma-glutamyltransferase
FRO58_RS14980	COG2814	Major facilitator Superfamily
FRO58_RS14990	COG2050	protein possibly involved in aromatic compounds catabolism
FRO58_RS15005	COG1090	epimerase
FRO58_RS15025	COG0420	3'-5' exonuclease activity
FRO58_RS15050	COG0735	belongs to the Fur family
FRO58_RS15055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FRO58_RS15075	COG0121	glutamine amidotransferase
FRO58_RS15090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRO58_RS15100	COG0210	DNA helicase
FRO58_RS15105	COG2885	chlorophyll binding
FRO58_RS15110	COG0204	Acyl-transferase
FRO58_RS15125	COG2894	cell division
FRO58_RS15150	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS15155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FRO58_RS15155	COG1674	ftsk spoiiie
FRO58_RS15160	COG0492	ferredoxin-NADP+ reductase activity
FRO58_RS15165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FRO58_RS15175	COG0456	acetyltransferase
FRO58_RS15220	COG1981	membrane
FRO58_RS15235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRO58_RS15235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FRO58_RS15255	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS15265	COG0657	acetylesterase activity
FRO58_RS15275	COG0473	3-isopropylmalate dehydrogenase activity
FRO58_RS15280	COG0583	DNA-binding transcription factor activity
FRO58_RS15300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FRO58_RS15325	COG0564	pseudouridine synthase activity
FRO58_RS15335	COG0358	DNA primase activity
FRO58_RS15350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FRO58_RS15380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FRO58_RS15410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FRO58_RS15420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FRO58_RS15420	COG0352	thiamine-phosphate diphosphorylase activity
FRO58_RS15420	COG0351	phosphomethylpyrimidine kinase
FRO58_RS15425	COG1652	LysM domain
FRO58_RS15450	COG1399	metal-binding, possibly nucleic acid-binding protein
FRO58_RS15455	COG3101	peptidyl-lysine hydroxylation
FRO58_RS15460	COG0009	L-threonylcarbamoyladenylate synthase
FRO58_RS15465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FRO58_RS15470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FRO58_RS15485	COG4106	trans-aconitate 2-methyltransferase activity
FRO58_RS15500	COG2226	methyltransferase
FRO58_RS15500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRO58_RS15500	COG0596	Alpha beta hydrolase
FRO58_RS15505	COG1877	trehalose-phosphatase activity
FRO58_RS15510	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FRO58_RS15515	COG2223	nitrite transmembrane transporter activity
FRO58_RS15535	COG1196	nuclear chromosome segregation
FRO58_RS15545	COG0730	response to heat
FRO58_RS15560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FRO58_RS15570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRO58_RS15620	COG0489	protein tyrosine kinase activity
FRO58_RS15630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRO58_RS15630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRO58_RS15660	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FRO58_RS15665	COG2081	HI0933 family
FRO58_RS15675	COG0668	transmembrane transport
FRO58_RS15695	COG0583	DNA-binding transcription factor activity
FRO58_RS15715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FRO58_RS15720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRO58_RS15750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FRO58_RS15790	COG0745	RESPONSE REGULATOR receiver
FRO58_RS15810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRO58_RS15820	COG2205	protein histidine kinase activity
FRO58_RS15890	COG4993	Dehydrogenase
FRO58_RS15915	COG0384	phenazine biosynthesis protein PhzF
FRO58_RS15935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FRO58_RS15950	COG0583	DNA-binding transcription factor activity
FRO58_RS15980	COG0583	DNA-binding transcription factor activity
FRO58_RS15995	COG0583	DNA-binding transcription factor activity
FRO58_RS16000	COG1053	succinate dehydrogenase
FRO58_RS16010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FRO58_RS16015	COG2814	Major facilitator Superfamily
FRO58_RS16020	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS16025	COG0583	DNA-binding transcription factor activity
FRO58_RS16030	COG1063	alcohol dehydrogenase
FRO58_RS16060	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FRO58_RS16065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FRO58_RS16070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRO58_RS16085	COG3667	copper resistance
FRO58_RS16090	COG2132	Multicopper oxidase
FRO58_RS16100	COG0561	phosphatase activity
FRO58_RS16105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FRO58_RS16130	COG1214	PFAM Peptidase M22, glycoprotease
FRO58_RS16180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FRO58_RS16190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FRO58_RS16195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FRO58_RS16200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FRO58_RS16260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FRO58_RS16270	COG1846	Transcriptional regulator
FRO58_RS16275	COG1764	response to oxidative stress
FRO58_RS16315	COG0037	tRNA processing
FRO58_RS16325	COG0248	Ppx GppA phosphatase
FRO58_RS16355	COG0072	phenylalanine-tRNA ligase activity
FRO58_RS16395	COG1238	metal cluster binding
FRO58_RS16400	COG0625	glutathione transferase activity
FRO58_RS16415	COG0318	PFAM AMP-dependent synthetase and ligase
FRO58_RS16420	COG3028	Belongs to the UPF0307 family
FRO58_RS16425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FRO58_RS16445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FRO58_RS16450	COG0617	tRNA 3'-terminal CCA addition
FRO58_RS16455	COG1555	photosystem II stabilization
FRO58_RS16460	COG3956	TIGRFAM MazG family protein
FRO58_RS16470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FRO58_RS16490	COG5002	protein histidine kinase activity
FRO58_RS16490	COG0784	Response regulator, receiver
FRO58_RS16490	COG2205	protein histidine kinase activity
FRO58_RS16495	COG1024	Enoyl-CoA hydratase
FRO58_RS16515	COG3622	Belongs to the hyi family
FRO58_RS16545	COG0697	spore germination
FRO58_RS16555	COG2814	Major facilitator Superfamily
FRO58_RS16560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FRO58_RS16570	COG0583	DNA-binding transcription factor activity
FRO58_RS16580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FRO58_RS16595	COG0084	hydrolase, TatD family'
FRO58_RS16610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FRO58_RS16640	COG0440	acetolactate synthase activity
FRO58_RS16645	COG0028	Belongs to the TPP enzyme family
FRO58_RS16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FRO58_RS16675	COG1136	(ABC) transporter
FRO58_RS16675	COG0577	efflux transmembrane transporter activity
FRO58_RS16680	COG1538	Outer membrane efflux protein
FRO58_RS16695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FRO58_RS16700	COG1162	GTPase activity
FRO58_RS16710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FRO58_RS16730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FRO58_RS16735	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS16775	COG2986	histidine ammonia-lyase
FRO58_RS16790	COG0318	PFAM AMP-dependent synthetase and ligase
FRO58_RS16800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRO58_RS16845	COG1426	Protein conserved in bacteria
FRO58_RS16880	COG0793	Belongs to the peptidase S41A family
FRO58_RS16895	COG2267	carboxylic ester hydrolase activity
FRO58_RS16905	COG1012	belongs to the aldehyde dehydrogenase family
FRO58_RS16910	COG3265	gluconokinase activity
FRO58_RS16920	COG0800	Aldolase
FRO58_RS16930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FRO58_RS16935	COG0857	belongs to the CobB CobQ family
FRO58_RS16935	COG0280	phosphate acetyltransferase
FRO58_RS16940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FRO58_RS16940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FRO58_RS16960	COG0740	serine-type endopeptidase activity
FRO58_RS16970	COG4774	siderophore transport
FRO58_RS16980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FRO58_RS16990	COG2813	Specifically methylates the guanine in position
FRO58_RS16990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FRO58_RS17090	COG0788	formyltetrahydrofolate deformylase activity
FRO58_RS17115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRO58_RS17115	COG4651	solute:proton antiporter activity
FRO58_RS17135	COG0724	RNA recognition motif
FRO58_RS17140	COG0210	DNA helicase
FRO58_RS17165	COG1733	regulation of RNA biosynthetic process
FRO58_RS17175	COG2900	Belongs to the SlyX family
FRO58_RS17180	COG0488	(ABC) transporter
FRO58_RS17185	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS17190	COG1560	Kdo2-lipid A biosynthetic process
FRO58_RS17200	COG1301	dicarboxylic acid transport
FRO58_RS17255	COG0473	3-isopropylmalate dehydrogenase activity
FRO58_RS17320	COG0583	DNA-binding transcription factor activity
FRO58_RS17330	COG0625	glutathione transferase activity
FRO58_RS17335	COG2378	regulation of single-species biofilm formation
FRO58_RS17340	COG0546	phosphoglycolate phosphatase activity
FRO58_RS17350	COG1530	ribonuclease E activity
FRO58_RS17355	COG0318	PFAM AMP-dependent synthetase and ligase
FRO58_RS17370	COG0583	DNA-binding transcription factor activity
FRO58_RS17375	COG4221	oxidoreductase activity
FRO58_RS17380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FRO58_RS17390	COG0534	Mate efflux family protein
FRO58_RS17405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FRO58_RS17445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FRO58_RS17450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FRO58_RS17465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FRO58_RS17475	COG0644	oxidoreductase
FRO58_RS17475	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FRO58_RS17480	COG0425	Belongs to the sulfur carrier protein TusA family
FRO58_RS17485	COG4535	Mg2 and Co2 transporter CorC
FRO58_RS17495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FRO58_RS17515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FRO58_RS17520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FRO58_RS17520	COG0475	glutathione-regulated potassium exporter activity
FRO58_RS17525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FRO58_RS17535	COG0484	heat shock protein binding
FRO58_RS17540	COG0789	Transcriptional regulator
FRO58_RS17545	COG0598	Magnesium transport protein CorA
FRO58_RS17560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FRO58_RS17565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FRO58_RS17570	COG1074	ATP-dependent DNA helicase activity
FRO58_RS17575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FRO58_RS17595	COG2226	methyltransferase
FRO58_RS17610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FRO58_RS17615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FRO58_RS17630	COG2111	Na H antiporter
FRO58_RS17630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FRO58_RS17635	COG1006	Multisubunit Na H antiporter MnhC subunit
FRO58_RS17640	COG0651	ATP synthesis coupled electron transport
FRO58_RS17645	COG1863	multisubunit Na H antiporter MnhE subunit
FRO58_RS17650	COG2212	antiporter activity
FRO58_RS17655	COG1320	monovalent cation:proton antiporter activity
FRO58_RS17670	COG0195	Participates in both transcription termination and antitermination
FRO58_RS17720	COG0237	dephospho-CoA kinase activity
FRO58_RS17730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FRO58_RS17745	COG0497	DNA recombination
FRO58_RS17755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FRO58_RS17785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FRO58_RS17785	COG2169	Transcriptional regulator
FRO58_RS17790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FRO58_RS17855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FRO58_RS17870	COG0326	Molecular chaperone. Has ATPase activity
FRO58_RS17885	COG2056	Na+-H+ antiporter family
FRO58_RS17890	COG0596	Alpha beta hydrolase
FRO58_RS17995	COG0546	phosphoglycolate phosphatase activity
FRO58_RS18000	COG1716	ATPase activity
FRO58_RS18045	COG0181	hydroxymethylbilane synthase activity
FRO58_RS18055	COG3275	phosphorelay sensor kinase activity
FRO58_RS18075	COG1538	Outer membrane efflux protein
FRO58_RS18080	COG0697	spore germination
FRO58_RS18105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FRO58_RS18110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FRO58_RS18115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FRO58_RS18120	COG0772	Belongs to the SEDS family
FRO58_RS18145	COG4974	Belongs to the 'phage' integrase family
FRO58_RS18150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRO58_RS18160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FRO58_RS18170	COG2197	response regulator
FRO58_RS18185	COG0793	Belongs to the peptidase S41A family
FRO58_RS18190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FRO58_RS18195	COG0795	lipopolysaccharide-transporting ATPase activity
FRO58_RS18235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRO58_RS18235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FRO58_RS18245	COG0004	ammonium transporteR
FRO58_RS18250	COG0347	Belongs to the P(II) protein family
FRO58_RS18260	COG0606	chelatase, subunit chli
FRO58_RS18315	COG0659	secondary active sulfate transmembrane transporter activity
FRO58_RS18320	COG0589	response to stress
FRO58_RS18395	COG0606	chelatase, subunit chli
FRO58_RS18400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FRO58_RS18410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FRO58_RS18425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FRO58_RS18440	COG0318	PFAM AMP-dependent synthetase and ligase
FRO58_RS18450	COG0477	Major facilitator Superfamily
FRO58_RS18455	COG2860	membrane
FRO58_RS18465	COG1253	flavin adenine dinucleotide binding
FRO58_RS18485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FRO58_RS18520	COG0655	NAD(P)H dehydrogenase (quinone) activity
FRO58_RS18530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FRO58_RS18565	COG1309	transcriptional regulator
FRO58_RS18600	COG0758	DNA mediated transformation
FRO58_RS18610	COG0697	spore germination
FRO58_RS18615	COG1309	transcriptional regulator
FRO58_RS18630	COG0386	Belongs to the glutathione peroxidase family
FRO58_RS18695	COG1121	(ABC) transporter
FRO58_RS18700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FRO58_RS18705	COG1280	lysine exporter protein (LysE YggA)
FRO58_RS18710	COG2837	iron assimilation
FRO58_RS18720	COG0281	malic enzyme
FRO58_RS18765	COG0519	Catalyzes the synthesis of GMP from XMP
FRO58_RS18765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FRO58_RS18770	COG4399	Belongs to the UPF0754 family
FRO58_RS18775	COG2259	Doxx family
FRO58_RS18780	COG0586	Pfam SNARE associated Golgi protein
FRO58_RS18795	COG1192	Involved in chromosome partitioning
FRO58_RS18805	COG0271	Belongs to the BolA IbaG family
FRO58_RS18825	COG2267	carboxylic ester hydrolase activity
FRO58_RS18845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FRO58_RS18845	COG3321	synthase
FRO58_RS18845	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FRO58_RS18845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FRO58_RS18850	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS18860	COG2197	response regulator
FRO58_RS18870	COG3916	Acyl-homoserine-lactone synthase
FRO58_RS18875	COG0477	Major facilitator Superfamily
FRO58_RS18880	COG1024	Enoyl-CoA hydratase
FRO58_RS18885	COG1024	Enoyl-CoA hydratase
FRO58_RS18890	COG1960	acyl-CoA dehydrogenase activity
FRO58_RS18895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FRO58_RS18915	COG1113	amino acid transport
FRO58_RS18920	COG1113	amino acid transport
FRO58_RS18925	COG0251	oxidation-reduction process
FRO58_RS18965	COG0564	pseudouridine synthase activity
FRO58_RS19025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FRO58_RS19040	COG1802	Transcriptional regulator
FRO58_RS19050	COG1448	Aminotransferase
FRO58_RS19055	COG0277	FAD linked oxidase domain protein
FRO58_RS19065	COG2186	Transcriptional regulator
FRO58_RS19075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FRO58_RS19080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FRO58_RS19095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FRO58_RS19100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FRO58_RS19105	COG1216	Glycosyl transferase, family 2
FRO58_RS19135	COG2089	acid synthase
FRO58_RS19150	COG1083	cytidylyl-transferase
FRO58_RS19155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FRO58_RS19160	COG1086	Polysaccharide biosynthesis protein
FRO58_RS19165	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FRO58_RS19170	COG1596	polysaccharide export
FRO58_RS19195	COG0728	peptidoglycan biosynthetic process
FRO58_RS19200	COG3023	N-Acetylmuramoyl-L-alanine amidase
FRO58_RS19255	COG0546	phosphoglycolate phosphatase activity
FRO58_RS19260	COG1028	Short-chain dehydrogenase reductase Sdr
FRO58_RS19280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRO58_RS19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FRO58_RS19290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FRO58_RS19295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FRO58_RS19300	COG1116	anion transmembrane transporter activity
FRO58_RS19305	COG1309	transcriptional regulator
FRO58_RS19310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FRO58_RS19320	COG0196	riboflavin kinase activity
FRO58_RS19325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FRO58_RS19335	COG1047	Peptidyl-prolyl cis-trans
FRO58_RS19375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FRO58_RS19380	COG0657	acetylesterase activity
FRO58_RS19430	COG2951	lytic endotransglycosylase activity
FRO58_RS19435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FRO58_RS19450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FRO58_RS19460	COG0671	phosphoesterase, PA-phosphatase related
FRO58_RS19465	COG0861	Integral membrane protein TerC family
FRO58_RS19475	COG0754	glutathionylspermidine amidase activity
FRO58_RS19485	COG0402	S-adenosylhomocysteine deaminase activity
FRO58_RS19500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FRO58_RS19505	COG1230	cation diffusion facilitator family transporter
FRO58_RS19520	COG0706	membrane insertase activity
FRO58_RS19545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRO58_RS19545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FRO58_RS19595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRO58_RS19595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FRO58_RS19600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FRO58_RS19640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FRO58_RS19680	COG2130	NADP-dependent
FRO58_RS19690	COG1309	transcriptional regulator
FRO58_RS19700	COG1902	pentaerythritol trinitrate reductase activity
FRO58_RS19710	COG1979	alcohol dehydrogenase
FRO58_RS19720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FRO58_RS19745	COG1063	alcohol dehydrogenase
FRO58_RS19825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FRO58_RS19845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FRO58_RS20025	COG0358	DNA primase activity
FRO58_RS20080	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FRO58_RS20125	COG0587	DNA-directed DNA polymerase activity