locus-tag	class	description
AOT18_RS00010	COG0592	DNA-directed DNA polymerase activity
AOT18_RS00020	COG0187	DNA topoisomerase II activity
AOT18_RS00030	COG0586	Pfam SNARE associated Golgi protein
AOT18_RS00035	COG0488	(ABC) transporter
AOT18_RS00060	COG0596	Alpha beta hydrolase
AOT18_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOT18_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT18_RS00110	COG0733	neurotransmitter:sodium symporter activity
AOT18_RS00150	COG2233	PERMEase
AOT18_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS00200	COG2814	Major facilitator Superfamily
AOT18_RS00205	COG0656	L-ascorbic acid biosynthetic process
AOT18_RS00210	COG0583	DNA-binding transcription factor activity
AOT18_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT18_RS00225	COG1064	alcohol dehydrogenase
AOT18_RS00230	COG2818	Glycosylase
AOT18_RS00245	COG1194	a g-specific adenine glycosylase
AOT18_RS00265	COG2983	Belongs to the UPF0260 family
AOT18_RS00270	COG2133	pyrroloquinoline quinone binding
AOT18_RS00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT18_RS00280	COG2116	formate transmembrane transporter activity
AOT18_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT18_RS00305	COG1335	isochorismatase
AOT18_RS00310	COG0385	Bile acid
AOT18_RS00315	COG0534	Mate efflux family protein
AOT18_RS00320	COG1683	Conserved Protein
AOT18_RS00340	COG0625	glutathione transferase activity
AOT18_RS00350	COG1113	amino acid transport
AOT18_RS00360	COG0523	cobalamin synthesis protein
AOT18_RS00370	COG2188	Transcriptional regulator
AOT18_RS00400	COG0010	Belongs to the arginase family
AOT18_RS00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOT18_RS00420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT18_RS00430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOT18_RS00435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOT18_RS00540	COG0534	Mate efflux family protein
AOT18_RS00545	COG0436	Aminotransferase
AOT18_RS00550	COG2733	membrane
AOT18_RS00565	COG2918	glutathione biosynthetic process
AOT18_RS00580	COG1388	LysM domain
AOT18_RS00580	COG0791	NLP P60 protein
AOT18_RS00605	COG3150	esterase
AOT18_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AOT18_RS00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT18_RS00640	COG2233	PERMEase
AOT18_RS00645	COG2351	hydroxyisourate hydrolase activity
AOT18_RS00680	COG3706	GGDEF domain
AOT18_RS00695	COG1393	Belongs to the ArsC family
AOT18_RS00700	COG0708	Exodeoxyribonuclease III
AOT18_RS00720	COG0189	ligase activity
AOT18_RS00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOT18_RS00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOT18_RS00765	COG4942	peptidase
AOT18_RS00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT18_RS00785	COG2119	membrane
AOT18_RS00790	COG4774	siderophore transport
AOT18_RS00810	COG4774	siderophore transport
AOT18_RS00815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOT18_RS00815	COG0426	domain, Protein
AOT18_RS00840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOT18_RS00860	COG1902	pentaerythritol trinitrate reductase activity
AOT18_RS00865	COG1519	Transferase
AOT18_RS00870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT18_RS00875	COG0668	transmembrane transport
AOT18_RS00885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT18_RS00890	COG1335	isochorismatase
AOT18_RS00895	COG1522	sequence-specific DNA binding
AOT18_RS00900	COG3328	transposase activity
AOT18_RS00925	COG2198	Histidine kinase
AOT18_RS00925	COG2205	protein histidine kinase activity
AOT18_RS00925	COG0784	Response regulator, receiver
AOT18_RS00930	COG3162	membrane
AOT18_RS00935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT18_RS00945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT18_RS00965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOT18_RS00970	COG1309	transcriptional regulator
AOT18_RS00990	COG0351	phosphomethylpyrimidine kinase
AOT18_RS00990	COG0352	thiamine-phosphate diphosphorylase activity
AOT18_RS00990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOT18_RS01000	COG2814	Major facilitator Superfamily
AOT18_RS01015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOT18_RS01025	COG1113	amino acid transport
AOT18_RS01035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOT18_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS01050	COG1335	isochorismatase
AOT18_RS01080	COG2814	Major facilitator Superfamily
AOT18_RS01085	COG0583	DNA-binding transcription factor activity
AOT18_RS01105	COG0667	Aldo Keto reductase
AOT18_RS01140	COG1733	regulation of RNA biosynthetic process
AOT18_RS01150	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT18_RS01215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOT18_RS01230	COG2329	Antibiotic biosynthesis monooxygenase
AOT18_RS01260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOT18_RS01290	COG0427	acetyl-CoA hydrolase
AOT18_RS01310	COG0659	secondary active sulfate transmembrane transporter activity
AOT18_RS01315	COG4221	oxidoreductase activity
AOT18_RS01320	COG2873	o-acetylhomoserine
AOT18_RS01325	COG0488	(ABC) transporter
AOT18_RS01405	COG0833	amino acid
AOT18_RS01450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOT18_RS01455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOT18_RS01470	COG2226	methyltransferase
AOT18_RS01520	COG0070	glutamate synthase
AOT18_RS01520	COG0069	glutamate synthase activity
AOT18_RS01520	COG0067	glutamate synthase
AOT18_RS01525	COG0493	'glutamate synthase
AOT18_RS01535	COG1704	LemA family
AOT18_RS01540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AOT18_RS01560	COG3307	-O-antigen
AOT18_RS01580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT18_RS01590	COG0194	GDP metabolic process
AOT18_RS01640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOT18_RS01660	COG5380	lipid catabolic process
AOT18_RS01665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOT18_RS01690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT18_RS01695	COG0277	FAD linked oxidase domain protein
AOT18_RS01705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AOT18_RS01710	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT18_RS01725	COG1289	transmembrane transporter activity
AOT18_RS01735	COG0628	permease
AOT18_RS01740	COG1192	Involved in chromosome partitioning
AOT18_RS01770	COG0833	amino acid
AOT18_RS01775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT18_RS01780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT18_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS01830	COG0583	DNA-binding transcription factor activity
AOT18_RS01875	COG0517	IMP dehydrogenase activity
AOT18_RS01880	COG1983	PspC domain protein
AOT18_RS01890	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS01905	COG0408	coproporphyrinogen oxidase activity
AOT18_RS01925	COG0513	Belongs to the DEAD box helicase family
AOT18_RS01930	COG1127	ABC transporter
AOT18_RS01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT18_RS01945	COG2854	intermembrane phospholipid transfer
AOT18_RS01955	COG0598	Magnesium transport protein CorA
AOT18_RS01965	COG0494	nUDIX hydrolase
AOT18_RS01970	COG1040	competence protein
AOT18_RS01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOT18_RS01995	COG1946	Acyl-CoA thioesterase
AOT18_RS02000	COG1301	dicarboxylic acid transport
AOT18_RS02015	COG1959	2 iron, 2 sulfur cluster binding
AOT18_RS02020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT18_RS02020	COG1017	nitric oxide dioxygenase activity
AOT18_RS02025	COG0433	COG0433 Predicted ATPase
AOT18_RS02030	COG0626	cystathionine gamma-synthase activity
AOT18_RS02185	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS02190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOT18_RS02220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AOT18_RS02225	COG0339	signal peptide processing
AOT18_RS02230	COG0557	exoribonuclease II activity
AOT18_RS02275	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOT18_RS02280	COG2169	Transcriptional regulator
AOT18_RS02285	COG0697	spore germination
AOT18_RS02290	COG1295	ribonuclease BN
AOT18_RS02325	COG1702	phosphate starvation-inducible protein PhoH
AOT18_RS02335	COG0741	lytic transglycosylase activity
AOT18_RS02335	COG0739	heme binding
AOT18_RS02335	COG1196	nuclear chromosome segregation
AOT18_RS02365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOT18_RS02370	COG1183	phosphatidylcholine synthase activity
AOT18_RS02415	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS02420	COG1309	transcriptional regulator
AOT18_RS02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT18_RS02440	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS02460	COG2969	positive regulation of protein catabolic process
AOT18_RS02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOT18_RS02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOT18_RS02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOT18_RS02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOT18_RS02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT18_RS02525	COG1408	metallophosphoesterase
AOT18_RS02535	COG2199	diguanylate cyclase activity
AOT18_RS02595	COG1607	acyl-coa hydrolase
AOT18_RS02625	COG2350	Protein conserved in bacteria
AOT18_RS02635	COG0613	PHP domain protein
AOT18_RS02640	COG3781	membrane
AOT18_RS02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOT18_RS02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT18_RS02665	COG1862	Preprotein translocase
AOT18_RS02710	COG2205	protein histidine kinase activity
AOT18_RS02715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOT18_RS02735	COG0726	polysaccharide deacetylase
AOT18_RS02740	COG0463	Glycosyl transferase, family 2
AOT18_RS02745	COG0438	transferase activity, transferring glycosyl groups
AOT18_RS02810	COG0625	glutathione transferase activity
AOT18_RS02815	COG0583	DNA-binding transcription factor activity
AOT18_RS02820	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS02825	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS02835	COG2205	protein histidine kinase activity
AOT18_RS02840	COG0745	RESPONSE REGULATOR receiver
AOT18_RS02845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOT18_RS02865	COG2096	Adenosyltransferase
AOT18_RS02915	COG0285	dihydrofolate synthase activity
AOT18_RS02935	COG0450	alkyl hydroperoxide reductase
AOT18_RS02950	COG0477	Major facilitator Superfamily
AOT18_RS02955	COG1272	protein, Hemolysin III
AOT18_RS02990	COG0183	Belongs to the thiolase family
AOT18_RS02995	COG2207	Transcriptional regulator
AOT18_RS03015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT18_RS03035	COG0183	Belongs to the thiolase family
AOT18_RS03045	COG2885	chlorophyll binding
AOT18_RS03045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AOT18_RS03055	COG1690	Belongs to the RtcB family
AOT18_RS03060	COG0833	amino acid
AOT18_RS03070	COG2233	PERMEase
AOT18_RS03075	COG1217	gtp-binding protein TYPA
AOT18_RS03100	COG2094	Belongs to the DNA glycosylase MPG family
AOT18_RS03105	COG4772	TonB-dependent receptor
AOT18_RS03125	COG4772	TonB-dependent receptor
AOT18_RS03130	COG1902	pentaerythritol trinitrate reductase activity
AOT18_RS03145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT18_RS03150	COG0354	folic acid binding
AOT18_RS03160	COG3189	MarR family transcriptional regulator
AOT18_RS03165	COG2824	Alkylphosphonate utilization operon protein PhnA
AOT18_RS03170	COG3422	double-strand break repair
AOT18_RS03210	COG0840	transmembrane signaling receptor activity
AOT18_RS03230	COG5510	response to toxic substance
AOT18_RS03240	COG2832	Protein of unknown function (DUF454)
AOT18_RS03245	COG1376	ErfK ybiS ycfS ynhG family protein
AOT18_RS03285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOT18_RS03295	COG1289	transmembrane transporter activity
AOT18_RS03300	COG2814	Major facilitator Superfamily
AOT18_RS03315	COG1115	amino acid carrier protein
AOT18_RS03320	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT18_RS03325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOT18_RS03330	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AOT18_RS03360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOT18_RS03370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOT18_RS03375	COG1077	Cell shape determining protein MreB Mrl
AOT18_RS03380	COG1792	Involved in formation and maintenance of cell shape
AOT18_RS03385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AOT18_RS03390	COG0424	maF-like protein
AOT18_RS03395	COG1530	ribonuclease E activity
AOT18_RS03400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOT18_RS03410	COG0560	Phosphoserine phosphatase
AOT18_RS03420	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT18_RS03445	COG2207	Transcriptional regulator
AOT18_RS03465	COG1113	amino acid transport
AOT18_RS03470	COG2828	Protein conserved in bacteria
AOT18_RS03475	COG0142	geranyltranstransferase activity
AOT18_RS03480	COG2315	Protein conserved in bacteria
AOT18_RS03495	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT18_RS03515	COG2194	sulfuric ester hydrolase activity
AOT18_RS03520	COG0745	RESPONSE REGULATOR receiver
AOT18_RS03525	COG0642	Histidine kinase
AOT18_RS03535	COG0004	ammonium transporteR
AOT18_RS03545	COG0583	DNA-binding transcription factor activity
AOT18_RS03565	COG0525	valine-tRNA ligase activity
AOT18_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS03585	COG0393	Putative heavy-metal-binding
AOT18_RS03590	COG0393	Putative heavy-metal-binding
AOT18_RS03595	COG1538	Outer membrane efflux protein
AOT18_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS03610	COG0671	phosphoesterase, PA-phosphatase related
AOT18_RS03640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOT18_RS03655	COG1648	precorrin-2 dehydrogenase activity
AOT18_RS03655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOT18_RS03660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOT18_RS03665	COG1733	regulation of RNA biosynthetic process
AOT18_RS03675	COG0531	amino acid
AOT18_RS03690	COG0321	lipoyl(octanoyl) transferase activity
AOT18_RS03695	COG2921	Belongs to the UPF0250 family
AOT18_RS03735	COG2009	succinate dehydrogenase
AOT18_RS03740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOT18_RS03745	COG1053	succinate dehydrogenase
AOT18_RS03750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOT18_RS03770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT18_RS03790	COG2354	Protein conserved in bacteria
AOT18_RS03795	COG2321	neutral zinc metallopeptidase
AOT18_RS03825	COG2843	Capsule synthesis protein
AOT18_RS03840	COG0589	response to stress
AOT18_RS03860	COG0505	Belongs to the CarA family
AOT18_RS03890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT18_RS03895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOT18_RS03945	COG0477	Major facilitator Superfamily
AOT18_RS03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOT18_RS03965	COG1597	lipid kinase activity
AOT18_RS03970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOT18_RS03995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT18_RS04000	COG0584	glycerophosphoryl diester phosphodiesterase
AOT18_RS04020	COG0741	lytic transglycosylase activity
AOT18_RS04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT18_RS04060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOT18_RS04090	COG0778	Nitroreductase
AOT18_RS04105	COG1929	Belongs to the glycerate kinase type-1 family
AOT18_RS04110	COG0243	molybdopterin cofactor binding
AOT18_RS04115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOT18_RS04120	COG3339	Conserved Protein
AOT18_RS04130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AOT18_RS04145	COG1113	amino acid transport
AOT18_RS04155	COG0019	diaminopimelate decarboxylase activity
AOT18_RS04165	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS04170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOT18_RS04200	COG0463	Glycosyl transferase, family 2
AOT18_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS04250	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT18_RS04255	COG1136	(ABC) transporter
AOT18_RS04260	COG2333	competence protein COMEC
AOT18_RS04260	COG0658	competence protein
AOT18_RS04270	COG0616	signal peptide processing
AOT18_RS04270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOT18_RS04275	COG0596	Alpha beta hydrolase
AOT18_RS04280	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOT18_RS04290	COG0628	permease
AOT18_RS04325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT18_RS04345	COG0823	Involved in the tonB-independent uptake of proteins
AOT18_RS04365	COG0824	Thioesterase
AOT18_RS04370	COG1473	amidohydrolase
AOT18_RS04390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOT18_RS04390	COG0047	phosphoribosylformylglycinamidine synthase activity
AOT18_RS04395	COG2814	Major facilitator Superfamily
AOT18_RS04405	COG1024	Enoyl-CoA hydratase
AOT18_RS04410	COG1056	cytidyltransferase-related domain
AOT18_RS04410	COG1051	belongs to the nudix hydrolase family
AOT18_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOT18_RS04435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOT18_RS04450	COG4625	pathogenesis
AOT18_RS04455	COG0583	DNA-binding transcription factor activity
AOT18_RS04460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOT18_RS04465	COG4208	sulfate ABC transporter
AOT18_RS04470	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AOT18_RS04480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOT18_RS04485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOT18_RS04490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOT18_RS04510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT18_RS04525	COG0681	Belongs to the peptidase S26 family
AOT18_RS04540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOT18_RS04550	COG1381	Involved in DNA repair and RecF pathway recombination
AOT18_RS04555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOT18_RS04565	COG4221	oxidoreductase activity
AOT18_RS04590	COG0436	Aminotransferase
AOT18_RS04610	COG0556	nucleotide-excision repair
AOT18_RS04665	COG2070	2-Nitropropane dioxygenase
AOT18_RS04695	COG1215	transferase activity, transferring glycosyl groups
AOT18_RS04710	COG0415	Belongs to the DNA photolyase family
AOT18_RS04720	COG1252	NADH dehydrogenase
AOT18_RS04725	COG1686	Belongs to the peptidase S11 family
AOT18_RS04740	COG1187	pseudouridine synthase activity
AOT18_RS04760	COG0477	Major facilitator Superfamily
AOT18_RS04765	COG0583	DNA-binding transcription factor activity
AOT18_RS04770	COG1823	symporter activity
AOT18_RS04780	COG0612	Peptidase, M16
AOT18_RS04805	COG0352	thiamine-phosphate diphosphorylase activity
AOT18_RS04840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT18_RS04855	COG1309	transcriptional regulator
AOT18_RS04865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOT18_RS04870	COG0076	glutamate decarboxylase activity
AOT18_RS04880	COG1522	sequence-specific DNA binding
AOT18_RS04885	COG3961	Belongs to the TPP enzyme family
AOT18_RS04890	COG1113	amino acid transport
AOT18_RS04895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT18_RS04900	COG0573	inorganic phosphate transmembrane transporter activity
AOT18_RS04910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOT18_RS04915	COG0616	signal peptide processing
AOT18_RS04950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOT18_RS04955	COG1686	Belongs to the peptidase S11 family
AOT18_RS04980	COG0583	DNA-binding transcription factor activity
AOT18_RS04985	COG1067	ATP-dependent peptidase activity
AOT18_RS05030	COG1966	Carbon starvation protein
AOT18_RS05035	COG2879	small protein
AOT18_RS05075	COG2508	Transcriptional regulator
AOT18_RS05075	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AOT18_RS05095	COG1113	amino acid transport
AOT18_RS05100	COG0583	DNA-binding transcription factor activity
AOT18_RS05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT18_RS05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT18_RS05120	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS05125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT18_RS05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT18_RS05130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AOT18_RS05165	COG2814	Major facilitator Superfamily
AOT18_RS05170	COG4948	Mandelate Racemase Muconate Lactonizing
AOT18_RS05180	COG1309	transcriptional regulator
AOT18_RS05200	COG1741	Belongs to the pirin family
AOT18_RS05210	COG2964	Protein conserved in bacteria
AOT18_RS05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOT18_RS05230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT18_RS05235	COG4605	iron ion homeostasis
AOT18_RS05240	COG4604	ABC transporter, ATP-binding protein
AOT18_RS05245	COG4607	ABC-type enterochelin transport system periplasmic component
AOT18_RS05250	COG4774	siderophore transport
AOT18_RS05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOT18_RS05265	COG1021	2,3-dihydroxybenzoate-AMP ligase
AOT18_RS05270	COG3433	isochorismatase activity
AOT18_RS05270	COG1535	isochorismatase
AOT18_RS05280	COG1132	(ABC) transporter
AOT18_RS05285	COG1132	(ABC) transporter
AOT18_RS05290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AOT18_RS05300	COG1169	isochorismate synthase
AOT18_RS05315	COG3739	integral membrane protein
AOT18_RS05350	COG0302	gtp cyclohydrolase
AOT18_RS05360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOT18_RS05390	COG0308	aminopeptidase N
AOT18_RS05395	COG0512	Glutamine amidotransferase of anthranilate synthase
AOT18_RS05410	COG0174	glutamine synthetase
AOT18_RS05420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOT18_RS05455	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOT18_RS05460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOT18_RS05465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT18_RS05485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT18_RS05490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOT18_RS05495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOT18_RS05510	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS05515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT18_RS05520	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT18_RS05530	COG2223	nitrite transmembrane transporter activity
AOT18_RS05540	COG0024	Methionine aminopeptidase
AOT18_RS05545	COG0052	Belongs to the universal ribosomal protein uS2 family
AOT18_RS05560	COG2207	Transcriptional regulator
AOT18_RS05585	COG2951	lytic endotransglycosylase activity
AOT18_RS05590	COG0772	Belongs to the SEDS family
AOT18_RS05605	COG0842	Transport permease protein
AOT18_RS05610	COG1131	(ABC) transporter
AOT18_RS05655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS05670	COG4215	(ABC) transporter
AOT18_RS05675	COG4160	amino acid transport
AOT18_RS05680	COG4598	ABC transporter
AOT18_RS05690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT18_RS05695	COG0826	peptidase U32
AOT18_RS05700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT18_RS05715	COG1720	tRNA m6t6A37 methyltransferase activity
AOT18_RS05725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT18_RS05740	COG0642	Histidine kinase
AOT18_RS05750	COG0494	nUDIX hydrolase
AOT18_RS05760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT18_RS05765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOT18_RS05770	COG3139	Protein of unknown function (DUF1315)
AOT18_RS05775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOT18_RS05785	COG1301	dicarboxylic acid transport
AOT18_RS05790	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS05795	COG2819	hydrolase of the alpha beta superfamily
AOT18_RS05805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOT18_RS05815	COG2195	Cleaves the N-terminal amino acid of tripeptides
AOT18_RS05820	COG1234	tRNA 3'-trailer cleavage
AOT18_RS05850	COG2363	Small membrane protein
AOT18_RS05870	COG0513	Belongs to the DEAD box helicase family
AOT18_RS05880	COG0778	Nitroreductase
AOT18_RS05910	COG1286	toxin biosynthetic process
AOT18_RS05935	COG4783	chaperone-mediated protein folding
AOT18_RS05940	COG1610	YqeY-like protein
AOT18_RS06040	COG3111	PFAM Bacterial OB fold (BOF) protein
AOT18_RS06065	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOT18_RS06070	COG0786	glutamate:sodium symporter activity
AOT18_RS06080	COG2186	Transcriptional regulator
AOT18_RS06145	COG0477	Major facilitator Superfamily
AOT18_RS06175	COG2985	domain, Protein
AOT18_RS06185	COG2995	paraquat-inducible protein a
AOT18_RS06190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT18_RS06190	COG3008	intermembrane lipid transfer
AOT18_RS06200	COG1794	racemase activity, acting on amino acids and derivatives
AOT18_RS06305	COG0488	(ABC) transporter
AOT18_RS06310	COG3173	Aminoglycoside phosphotransferase
AOT18_RS06320	COG2433	Pfam Transposase IS66
AOT18_RS06360	COG1301	dicarboxylic acid transport
AOT18_RS06370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT18_RS06375	COG2011	ABC-type metal ion transport system permease component
AOT18_RS06380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOT18_RS06385	COG1464	Belongs to the NlpA lipoprotein family
AOT18_RS06390	COG0151	Belongs to the GarS family
AOT18_RS06395	COG0138	bifunctional purine biosynthesis protein purh
AOT18_RS06400	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOT18_RS06430	COG2308	Evidence 4 Homologs of previously reported genes of
AOT18_RS06440	COG1305	Transglutaminase-like
AOT18_RS06450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOT18_RS06455	COG0305	Participates in initiation and elongation during chromosome replication
AOT18_RS06480	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOT18_RS06490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT18_RS06495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOT18_RS06520	COG1649	PFAM Uncharacterised BCR, COG1649
AOT18_RS06520	COG0726	polysaccharide deacetylase
AOT18_RS06525	COG1215	transferase activity, transferring glycosyl groups
AOT18_RS06530	COG3658	cytochrome
AOT18_RS06540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT18_RS06560	COG0583	DNA-binding transcription factor activity
AOT18_RS06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOT18_RS06585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT18_RS06600	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS06605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT18_RS06610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOT18_RS06635	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOT18_RS06640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AOT18_RS06650	COG2205	protein histidine kinase activity
AOT18_RS06655	COG0745	RESPONSE REGULATOR receiver
AOT18_RS06660	COG0174	glutamine synthetase
AOT18_RS06680	COG0729	surface antigen
AOT18_RS06710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT18_RS06715	COG2814	Major facilitator Superfamily
AOT18_RS06730	COG0583	DNA-binding transcription factor activity
AOT18_RS06745	COG1187	pseudouridine synthase activity
AOT18_RS06765	COG0802	atpase or kinase
AOT18_RS06770	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOT18_RS06780	COG1923	regulation of RNA biosynthetic process
AOT18_RS06785	COG0697	spore germination
AOT18_RS06800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT18_RS06810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT18_RS06815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT18_RS06815	COG0519	Catalyzes the synthesis of GMP from XMP
AOT18_RS06820	COG4302	ethanolamine ammonia-lyase activity
AOT18_RS06825	COG4303	Ethanolamine ammonia lyase large subunit
AOT18_RS06830	COG0531	amino acid
AOT18_RS06850	COG1454	alcohol dehydrogenase
AOT18_RS06855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT18_RS06865	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AOT18_RS06885	COG0308	aminopeptidase N
AOT18_RS06895	COG4221	oxidoreductase activity
AOT18_RS06905	COG1605	Chorismate mutase
AOT18_RS06930	COG1309	transcriptional regulator
AOT18_RS06940	COG0668	transmembrane transport
AOT18_RS06985	COG4773	Receptor
AOT18_RS07000	COG0488	(ABC) transporter
AOT18_RS07005	COG0589	response to stress
AOT18_RS07020	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOT18_RS07030	COG3135	benzoate transporter
AOT18_RS07035	COG1522	sequence-specific DNA binding
AOT18_RS07045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOT18_RS07050	COG0583	DNA-binding transcription factor activity
AOT18_RS07060	COG0183	Belongs to the thiolase family
AOT18_RS07070	COG2030	dehydratase
AOT18_RS07075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT18_RS07090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOT18_RS07100	COG0824	Thioesterase
AOT18_RS07105	COG1454	alcohol dehydrogenase
AOT18_RS07115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOT18_RS07135	COG0069	glutamate synthase activity
AOT18_RS07425	COG1598	PFAM Uncharacterised protein family UPF0150
AOT18_RS07460	COG0739	heme binding
AOT18_RS07580	COG2814	Major facilitator Superfamily
AOT18_RS07595	COG0511	ligase activity, forming carbon-carbon bonds
AOT18_RS07610	COG1116	anion transmembrane transporter activity
AOT18_RS07610	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT18_RS07615	COG0745	RESPONSE REGULATOR receiver
AOT18_RS07625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT18_RS07625	COG2146	nitrite reductase [NAD(P)H] activity
AOT18_RS07630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT18_RS07635	COG0243	molybdopterin cofactor binding
AOT18_RS07645	COG0243	molybdopterin cofactor binding
AOT18_RS07650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOT18_RS07665	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOT18_RS07665	COG0315	cyclic pyranopterin monophosphate synthase activity
AOT18_RS07670	COG0303	'Molybdopterin
AOT18_RS07680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT18_RS07685	COG0697	spore germination
AOT18_RS07705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AOT18_RS07710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT18_RS07805	COG2204	response regulator
AOT18_RS07810	COG3852	Histidine kinase
AOT18_RS07830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOT18_RS07835	COG0575	Belongs to the CDS family
AOT18_RS07870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT18_RS07885	COG2137	regulation of response to DNA damage stimulus
AOT18_RS07895	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOT18_RS07900	COG1011	Hydrolase
AOT18_RS07925	COG1522	sequence-specific DNA binding
AOT18_RS07935	COG1113	amino acid transport
AOT18_RS07950	COG0659	secondary active sulfate transmembrane transporter activity
AOT18_RS07955	COG2135	peptidase activity
AOT18_RS07970	COG5001	Diguanylate cyclase
AOT18_RS07970	COG3300	MHYT domain
AOT18_RS07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT18_RS07990	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AOT18_RS07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOT18_RS07995	COG1105	Belongs to the carbohydrate kinase PfkB family
AOT18_RS08000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT18_RS08000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOT18_RS08030	COG0024	Methionine aminopeptidase
AOT18_RS08035	COG0583	DNA-binding transcription factor activity
AOT18_RS08045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT18_RS08050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT18_RS08055	COG0516	GMP reductase activity
AOT18_RS08055	COG0517	IMP dehydrogenase activity
AOT18_RS08085	COG0552	protein localization to endoplasmic reticulum
AOT18_RS08095	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AOT18_RS08110	COG4890	Cyd operon protein YbgT
AOT18_RS08115	COG1294	oxidase, subunit
AOT18_RS08130	COG1585	Membrane protein implicated in regulation of membrane protease activity
AOT18_RS08140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT18_RS08145	COG4774	siderophore transport
AOT18_RS08160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOT18_RS08165	COG0569	domain protein
AOT18_RS08170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOT18_RS08200	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOT18_RS08205	COG0542	response to heat
AOT18_RS08230	COG1902	pentaerythritol trinitrate reductase activity
AOT18_RS08230	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT18_RS08275	COG2323	membrane
AOT18_RS08280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOT18_RS08290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOT18_RS08295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOT18_RS08300	COG0183	Belongs to the thiolase family
AOT18_RS08305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOT18_RS08310	COG0596	Alpha beta hydrolase
AOT18_RS08315	COG2271	Major facilitator Superfamily
AOT18_RS08320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOT18_RS08325	COG3485	protocatechuate 3,4-dioxygenase
AOT18_RS08330	COG3485	protocatechuate 3,4-dioxygenase
AOT18_RS08335	COG0710	3-dehydroquinate dehydratase activity
AOT18_RS08340	COG3420	alginic acid biosynthetic process
AOT18_RS08345	COG3659	wide pore channel activity
AOT18_RS08350	COG4993	Dehydrogenase
AOT18_RS08360	COG2391	methyltransferase activity
AOT18_RS08375	COG1414	Transcriptional regulator
AOT18_RS08380	COG0583	DNA-binding transcription factor activity
AOT18_RS08385	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS08410	COG2814	Major facilitator Superfamily
AOT18_RS08420	COG0154	amidase activity
AOT18_RS08440	COG4638	Rieske (2fe-2S)
AOT18_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS08460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOT18_RS08470	COG3733	amine oxidase
AOT18_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS08490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT18_RS08495	COG0183	Belongs to the thiolase family
AOT18_RS08500	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOT18_RS08505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOT18_RS08515	COG4829	muconolactone delta-isomerase
AOT18_RS08520	COG4948	Mandelate Racemase Muconate Lactonizing
AOT18_RS08525	COG0583	DNA-binding transcription factor activity
AOT18_RS08535	COG2186	Transcriptional regulator
AOT18_RS08555	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS08575	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS08585	COG3829	transcription factor binding
AOT18_RS08595	COG3162	membrane
AOT18_RS08610	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS08625	COG0753	catalase activity
AOT18_RS08650	COG1846	Transcriptional regulator
AOT18_RS08655	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT18_RS08655	COG1902	pentaerythritol trinitrate reductase activity
AOT18_RS08665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AOT18_RS08695	COG1309	transcriptional regulator
AOT18_RS08705	COG1335	isochorismatase
AOT18_RS08710	COG0583	DNA-binding transcription factor activity
AOT18_RS08720	COG0475	glutathione-regulated potassium exporter activity
AOT18_RS08720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT18_RS08730	COG1473	amidohydrolase
AOT18_RS08745	COG2831	hemolysin activation secretion protein
AOT18_RS08750	COG3210	domain, Protein
AOT18_RS08775	COG2188	Transcriptional regulator
AOT18_RS08805	COG0583	DNA-binding transcription factor activity
AOT18_RS08835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOT18_RS08855	COG1566	PFAM secretion protein HlyD family protein
AOT18_RS08870	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS08875	COG0129	dihydroxy-acid dehydratase activity
AOT18_RS08885	COG0583	DNA-binding transcription factor activity
AOT18_RS08890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT18_RS08900	COG2084	Dehydrogenase
AOT18_RS08905	COG2207	Transcriptional regulator
AOT18_RS08920	COG1064	alcohol dehydrogenase
AOT18_RS08930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT18_RS08935	COG1120	ATPase activity
AOT18_RS08955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT18_RS09075	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOT18_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS09145	COG2207	Transcriptional regulator
AOT18_RS09155	COG2205	protein histidine kinase activity
AOT18_RS09160	COG0745	RESPONSE REGULATOR receiver
AOT18_RS09165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS09170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT18_RS09175	COG1538	Outer membrane efflux protein
AOT18_RS09185	COG2072	flavoprotein involved in K transport
AOT18_RS09205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT18_RS09225	COG3539	Fimbrial protein
AOT18_RS09265	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOT18_RS09275	COG0753	catalase activity
AOT18_RS09290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT18_RS09350	COG1535	isochorismatase
AOT18_RS09350	COG3433	isochorismatase activity
AOT18_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS09360	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOT18_RS09365	COG4149	molybdate abc transporter
AOT18_RS09370	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOT18_RS09380	COG4638	Rieske (2fe-2S)
AOT18_RS09385	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOT18_RS09390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT18_RS09390	COG0543	2 iron, 2 sulfur cluster binding
AOT18_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS09430	COG2207	Transcriptional regulator
AOT18_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS09450	COG2610	gluconate transmembrane transporter activity
AOT18_RS09460	COG0583	DNA-binding transcription factor activity
AOT18_RS09470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOT18_RS09475	COG2031	fatty acid transporter
AOT18_RS09480	COG0183	Belongs to the thiolase family
AOT18_RS09485	COG0583	DNA-binding transcription factor activity
AOT18_RS09490	COG0583	DNA-binding transcription factor activity
AOT18_RS09505	COG1027	Aspartate ammonia-lyase
AOT18_RS09515	COG0477	Major facilitator Superfamily
AOT18_RS09535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOT18_RS09540	COG4521	taurine ABC transporter
AOT18_RS09555	COG2188	Transcriptional regulator
AOT18_RS09565	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOT18_RS09570	COG1733	regulation of RNA biosynthetic process
AOT18_RS09575	COG3708	Transcriptional regulator
AOT18_RS09575	COG2207	Transcriptional regulator
AOT18_RS09590	COG0730	response to heat
AOT18_RS09600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT18_RS09600	COG3453	Protein conserved in bacteria
AOT18_RS09610	COG3781	membrane
AOT18_RS09615	COG1063	alcohol dehydrogenase
AOT18_RS09625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT18_RS09630	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT18_RS09635	COG0022	dehydrogenase e1 component
AOT18_RS09640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOT18_RS09645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT18_RS09660	COG3706	GGDEF domain
AOT18_RS09675	COG0133	tryptophan synthase activity
AOT18_RS09685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT18_RS09715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOT18_RS09740	COG2226	methyltransferase
AOT18_RS09795	COG0842	Transport permease protein
AOT18_RS09800	COG0842	Transport permease protein
AOT18_RS09805	COG1131	(ABC) transporter
AOT18_RS09820	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT18_RS09825	COG4773	Receptor
AOT18_RS09845	COG0730	response to heat
AOT18_RS09850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT18_RS09870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOT18_RS09925	COG4264	IucA IucC family
AOT18_RS09930	COG4264	IucA IucC family
AOT18_RS09950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOT18_RS09965	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS09970	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS09975	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT18_RS09980	COG2207	Transcriptional regulator
AOT18_RS09985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT18_RS09990	COG0776	regulation of translation
AOT18_RS10015	COG0822	iron-sulfur transferase activity
AOT18_RS10020	COG0316	Belongs to the HesB IscA family
AOT18_RS10050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOT18_RS10070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOT18_RS10075	COG0702	epimerase
AOT18_RS10110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT18_RS10120	COG0339	signal peptide processing
AOT18_RS10165	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOT18_RS10170	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOT18_RS10200	COG0776	regulation of translation
AOT18_RS10265	COG0084	hydrolase, TatD family'
AOT18_RS10285	COG1663	tetraacyldisaccharide 4'-kinase activity
AOT18_RS10290	COG1132	(ABC) transporter
AOT18_RS10300	COG0811	peptide transport
AOT18_RS10305	COG1475	DNA binding
AOT18_RS10310	COG1192	Involved in chromosome partitioning
AOT18_RS10320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOT18_RS10335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT18_RS10340	COG0191	fructose-bisphosphate aldolase activity
AOT18_RS10360	COG0424	maF-like protein
AOT18_RS10365	COG2850	peptidyl-arginine hydroxylation
AOT18_RS10375	COG0640	Transcriptional regulator
AOT18_RS10385	COG3619	membrane
AOT18_RS10390	COG3122	Protein conserved in bacteria
AOT18_RS10395	COG1132	(ABC) transporter
AOT18_RS10415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOT18_RS10420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT18_RS10430	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOT18_RS10430	COG0506	proline dehydrogenase activity
AOT18_RS10430	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOT18_RS10435	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AOT18_RS10450	COG3698	Phosphodiester glycosidase
AOT18_RS10470	COG1765	OsmC-like protein
AOT18_RS10495	COG2353	YceI-like domain
AOT18_RS10505	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT18_RS10550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOT18_RS10550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOT18_RS10575	COG3539	Fimbrial protein
AOT18_RS10580	COG3121	Chaperone
AOT18_RS10610	COG0697	spore germination
AOT18_RS10620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOT18_RS10630	COG0583	DNA-binding transcription factor activity
AOT18_RS10650	COG1309	transcriptional regulator
AOT18_RS10665	COG1522	sequence-specific DNA binding
AOT18_RS10675	COG1126	abc transporter atp-binding protein
AOT18_RS10680	COG0765	amino acid transport
AOT18_RS10685	COG0765	amino acid transport
AOT18_RS10715	COG1464	Belongs to the NlpA lipoprotein family
AOT18_RS10725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOT18_RS10730	COG2011	ABC-type metal ion transport system permease component
AOT18_RS10735	COG0012	GTP binding
AOT18_RS10760	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOT18_RS10800	COG0386	Belongs to the glutathione peroxidase family
AOT18_RS10810	COG0436	Aminotransferase
AOT18_RS10850	COG3634	alkyl hydroperoxide reductase activity
AOT18_RS10865	COG0583	DNA-binding transcription factor activity
AOT18_RS10870	COG0798	PFAM Bile acid sodium symporter
AOT18_RS10875	COG0640	Transcriptional regulator
AOT18_RS10890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOT18_RS10900	COG0583	DNA-binding transcription factor activity
AOT18_RS10910	COG1953	Uracil, thiamine, allantoin
AOT18_RS10920	COG2175	clavaminate synthase activity
AOT18_RS10925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOT18_RS10930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AOT18_RS10935	COG4521	taurine ABC transporter
AOT18_RS10945	COG0477	Major facilitator Superfamily
AOT18_RS10970	COG1271	oxidase subunit
AOT18_RS10975	COG1294	oxidase, subunit
AOT18_RS10980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT18_RS11000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AOT18_RS11020	COG3052	prosthetic group binding
AOT18_RS11025	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AOT18_RS11035	COG2814	Major facilitator Superfamily
AOT18_RS11055	COG1346	cytolysis
AOT18_RS11065	COG0583	DNA-binding transcription factor activity
AOT18_RS11070	COG0625	glutathione transferase activity
AOT18_RS11075	COG0625	glutathione transferase activity
AOT18_RS11080	COG0583	DNA-binding transcription factor activity
AOT18_RS11095	COG1045	serine acetyltransferase
AOT18_RS11100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT18_RS11105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOT18_RS11110	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT18_RS11125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT18_RS11130	COG1126	abc transporter atp-binding protein
AOT18_RS11135	COG0765	amino acid transport
AOT18_RS11140	COG0765	amino acid transport
AOT18_RS11155	COG2205	protein histidine kinase activity
AOT18_RS11155	COG0784	Response regulator, receiver
AOT18_RS11175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOT18_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS11240	COG0583	DNA-binding transcription factor activity
AOT18_RS11260	COG0318	PFAM AMP-dependent synthetase and ligase
AOT18_RS11265	COG1309	transcriptional regulator
AOT18_RS11270	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS11275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT18_RS11280	COG1024	Enoyl-CoA hydratase
AOT18_RS11285	COG4770	biotin carboxylase activity
AOT18_RS11295	COG0583	DNA-binding transcription factor activity
AOT18_RS11310	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS11320	COG2814	Major facilitator Superfamily
AOT18_RS11330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOT18_RS11335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOT18_RS11340	COG2814	Major facilitator Superfamily
AOT18_RS11345	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS11350	COG1024	Enoyl-CoA hydratase
AOT18_RS11355	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS11360	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT18_RS11365	COG0183	Belongs to the thiolase family
AOT18_RS11375	COG2814	Major facilitator Superfamily
AOT18_RS11385	COG1024	Enoyl-CoA hydratase
AOT18_RS11400	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS11405	COG2814	Major facilitator Superfamily
AOT18_RS11410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT18_RS11415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOT18_RS11430	COG3842	ATPase activity
AOT18_RS11435	COG1840	ABC-type Fe3 transport system, periplasmic component
AOT18_RS11445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT18_RS11450	COG1414	Transcriptional regulator
AOT18_RS11460	COG0583	DNA-binding transcription factor activity
AOT18_RS11465	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOT18_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS11480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOT18_RS11485	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS11490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT18_RS11515	COG3038	cytochrome b561
AOT18_RS11520	COG0753	catalase activity
AOT18_RS11560	COG2050	protein possibly involved in aromatic compounds catabolism
AOT18_RS11570	COG3327	negative regulation of DNA-templated transcription, initiation
AOT18_RS11575	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AOT18_RS11580	COG0183	Belongs to the thiolase family
AOT18_RS11585	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT18_RS11590	COG1024	Enoyl-CoA hydratase
AOT18_RS11595	COG1024	Enoyl-CoA hydratase
AOT18_RS11600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT18_RS11605	COG2151	metal-sulfur cluster biosynthetic enzyme
AOT18_RS11610	COG3396	Phenylacetate-CoA oxygenase
AOT18_RS11615	COG3460	Phenylacetate-CoA oxygenase
AOT18_RS11620	COG3396	Phenylacetate-CoA oxygenase
AOT18_RS11625	COG2030	dehydratase
AOT18_RS11625	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS11630	COG1760	l-serine dehydratase
AOT18_RS11635	COG0531	amino acid
AOT18_RS11640	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS11655	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT18_RS11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT18_RS11685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT18_RS11700	COG0789	Transcriptional regulator
AOT18_RS11725	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOT18_RS11740	COG2807	transmembrane transport
AOT18_RS11745	COG0590	tRNA wobble adenosine to inosine editing
AOT18_RS11865	COG1116	anion transmembrane transporter activity
AOT18_RS11870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT18_RS11880	COG0864	Transcriptional regulator
AOT18_RS11895	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT18_RS11900	COG0439	Biotin carboxylase
AOT18_RS11915	COG1063	alcohol dehydrogenase
AOT18_RS11925	COG1309	transcriptional regulator
AOT18_RS11955	COG0038	chloride channel
AOT18_RS11960	COG4770	biotin carboxylase activity
AOT18_RS11980	COG1914	H( )-stimulated, divalent metal cation uptake system
AOT18_RS11985	COG0583	DNA-binding transcription factor activity
AOT18_RS12040	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT18_RS12060	COG2814	Major facilitator Superfamily
AOT18_RS12075	COG1560	Kdo2-lipid A biosynthetic process
AOT18_RS12085	COG5006	permease, DMT superfamily
AOT18_RS12090	COG1522	sequence-specific DNA binding
AOT18_RS12105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOT18_RS12115	COG4122	O-methyltransferase activity
AOT18_RS12145	COG1538	Outer membrane efflux protein
AOT18_RS12150	COG1137	ATPase activity
AOT18_RS12155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOT18_RS12165	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOT18_RS12170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AOT18_RS12170	COG0517	IMP dehydrogenase activity
AOT18_RS12210	COG2814	Major facilitator Superfamily
AOT18_RS12245	COG1278	Cold shock
AOT18_RS12250	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS12285	COG1570	exodeoxyribonuclease VII activity
AOT18_RS12340	COG0583	DNA-binding transcription factor activity
AOT18_RS12345	COG4638	Rieske (2fe-2S)
AOT18_RS12350	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOT18_RS12355	COG0543	2 iron, 2 sulfur cluster binding
AOT18_RS12355	COG0633	Ferredoxin
AOT18_RS12360	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS12365	COG3135	benzoate transporter
AOT18_RS12370	COG2814	Major facilitator Superfamily
AOT18_RS12385	COG1643	Atp-dependent helicase
AOT18_RS12390	COG0450	alkyl hydroperoxide reductase
AOT18_RS12400	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT18_RS12410	COG3634	alkyl hydroperoxide reductase activity
AOT18_RS12430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOT18_RS12435	COG0625	glutathione transferase activity
AOT18_RS12445	COG2885	chlorophyll binding
AOT18_RS12480	COG0542	response to heat
AOT18_RS12510	COG1765	OsmC-like protein
AOT18_RS12535	COG0667	Aldo Keto reductase
AOT18_RS12550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT18_RS12560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT18_RS12570	COG0527	aspartate kinase activity
AOT18_RS12580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOT18_RS12590	COG3038	cytochrome b561
AOT18_RS12595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOT18_RS12600	COG2252	PERMEase
AOT18_RS12610	COG2072	flavoprotein involved in K transport
AOT18_RS12625	COG1741	Belongs to the pirin family
AOT18_RS12630	COG1309	transcriptional regulator
AOT18_RS12640	COG0300	oxidoreductase activity
AOT18_RS12645	COG2072	flavoprotein involved in K transport
AOT18_RS12680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AOT18_RS12720	COG1113	amino acid transport
AOT18_RS12740	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS12760	COG0531	amino acid
AOT18_RS12770	COG1113	amino acid transport
AOT18_RS12815	COG3209	COG3209 Rhs family protein
AOT18_RS12845	COG4269	membrane
AOT18_RS12860	COG1902	pentaerythritol trinitrate reductase activity
AOT18_RS12860	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT18_RS12870	COG3706	GGDEF domain
AOT18_RS12870	COG2203	Gaf domain
AOT18_RS12870	COG5001	Diguanylate cyclase
AOT18_RS12870	COG4251	negative regulation of phosphorylation
AOT18_RS12880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT18_RS12900	COG4172	Belongs to the ABC transporter superfamily
AOT18_RS12905	COG4239	(ABC) transporter, permease
AOT18_RS12910	COG4174	ABC transporter (Permease)
AOT18_RS12920	COG0741	lytic transglycosylase activity
AOT18_RS12920	COG0741	lytic transglycosylase activity
AOT18_RS12920	COG1388	LysM domain
AOT18_RS12920	COG1388	LysM domain
AOT18_RS12925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT18_RS12965	COG0583	DNA-binding transcription factor activity
AOT18_RS12970	COG1279	arginine transmembrane transporter activity
AOT18_RS12990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT18_RS12995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT18_RS13000	COG0006	proline dipeptidase activity
AOT18_RS13035	COG2194	sulfuric ester hydrolase activity
AOT18_RS13080	COG0739	heme binding
AOT18_RS13400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOT18_RS13425	COG3384	dioxygenase
AOT18_RS13435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT18_RS13440	COG2878	Part of a membrane complex involved in electron transport
AOT18_RS13445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOT18_RS13465	COG0768	penicillin binding
AOT18_RS13470	COG0742	ribosomal rna small subunit methyltransferase
AOT18_RS13485	COG0830	nickel cation binding
AOT18_RS13495	COG0804	urea catabolic process
AOT18_RS13535	COG1253	flavin adenine dinucleotide binding
AOT18_RS13545	COG2851	Citrate transporter
AOT18_RS13590	COG1773	rubredoxin
AOT18_RS13595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT18_RS13605	COG0583	DNA-binding transcription factor activity
AOT18_RS13630	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOT18_RS13635	COG4181	ATPase activity
AOT18_RS13680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT18_RS13695	COG0306	phosphate transporter
AOT18_RS13705	COG3958	Transketolase
AOT18_RS13710	COG3959	Transketolase, thiamine diphosphate binding domain
AOT18_RS13715	COG2271	Major facilitator Superfamily
AOT18_RS13720	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS13725	COG0583	DNA-binding transcription factor activity
AOT18_RS13745	COG2223	nitrite transmembrane transporter activity
AOT18_RS13750	COG2207	Transcriptional regulator
AOT18_RS13755	COG2066	Belongs to the glutaminase family
AOT18_RS13760	COG0242	peptide deformylase activity
AOT18_RS13765	COG0477	Major facilitator Superfamily
AOT18_RS13775	COG0028	Belongs to the TPP enzyme family
AOT18_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS13795	COG2267	carboxylic ester hydrolase activity
AOT18_RS13805	COG2271	Major facilitator Superfamily
AOT18_RS13810	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT18_RS13820	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS13840	COG1414	Transcriptional regulator
AOT18_RS13855	COG1024	Enoyl-CoA hydratase
AOT18_RS13865	COG1215	transferase activity, transferring glycosyl groups
AOT18_RS13870	COG0726	polysaccharide deacetylase
AOT18_RS13870	COG1649	PFAM Uncharacterised BCR, COG1649
AOT18_RS13880	COG4681	YaeQ
AOT18_RS13890	COG0523	cobalamin synthesis protein
AOT18_RS13900	COG1607	acyl-coa hydrolase
AOT18_RS13910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT18_RS13915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT18_RS13920	COG1309	transcriptional regulator
AOT18_RS13945	COG2040	homocysteine
AOT18_RS13950	COG0531	amino acid
AOT18_RS13975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT18_RS13980	COG0477	Major facilitator Superfamily
AOT18_RS14100	COG0592	DNA-directed DNA polymerase activity
AOT18_RS14140	COG2026	Addiction module toxin, RelE StbE family
AOT18_RS14290	COG3755	Protein conserved in bacteria
AOT18_RS14335	COG1484	DNA-dependent DNA replication
AOT18_RS14425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT18_RS14490	COG0405	Gamma-glutamyltransferase
AOT18_RS14495	COG2814	Major facilitator Superfamily
AOT18_RS14505	COG2050	protein possibly involved in aromatic compounds catabolism
AOT18_RS14520	COG1090	epimerase
AOT18_RS14540	COG0420	3'-5' exonuclease activity
AOT18_RS14565	COG0735	belongs to the Fur family
AOT18_RS14570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT18_RS14595	COG0121	glutamine amidotransferase
AOT18_RS14610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT18_RS14620	COG0210	DNA helicase
AOT18_RS14625	COG2885	chlorophyll binding
AOT18_RS14630	COG0204	Acyl-transferase
AOT18_RS14645	COG2894	cell division
AOT18_RS14670	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS14675	COG1674	ftsk spoiiie
AOT18_RS14675	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOT18_RS14680	COG0492	ferredoxin-NADP+ reductase activity
AOT18_RS14685	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOT18_RS14695	COG0456	acetyltransferase
AOT18_RS14740	COG1981	membrane
AOT18_RS14755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT18_RS14755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOT18_RS14775	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS14785	COG0657	acetylesterase activity
AOT18_RS14795	COG0473	3-isopropylmalate dehydrogenase activity
AOT18_RS14800	COG0583	DNA-binding transcription factor activity
AOT18_RS14820	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT18_RS14845	COG0564	pseudouridine synthase activity
AOT18_RS14855	COG0358	DNA primase activity
AOT18_RS14870	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOT18_RS14895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT18_RS14925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT18_RS14935	COG0351	phosphomethylpyrimidine kinase
AOT18_RS14935	COG0352	thiamine-phosphate diphosphorylase activity
AOT18_RS14935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOT18_RS14940	COG1652	LysM domain
AOT18_RS15035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT18_RS15065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT18_RS15075	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOT18_RS15075	COG0352	thiamine-phosphate diphosphorylase activity
AOT18_RS15075	COG0351	phosphomethylpyrimidine kinase
AOT18_RS15080	COG1652	LysM domain
AOT18_RS15105	COG1399	metal-binding, possibly nucleic acid-binding protein
AOT18_RS15110	COG3101	peptidyl-lysine hydroxylation
AOT18_RS15115	COG0009	L-threonylcarbamoyladenylate synthase
AOT18_RS15120	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOT18_RS15125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOT18_RS15140	COG4106	trans-aconitate 2-methyltransferase activity
AOT18_RS15155	COG2226	methyltransferase
AOT18_RS15155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT18_RS15155	COG0596	Alpha beta hydrolase
AOT18_RS15160	COG1877	trehalose-phosphatase activity
AOT18_RS15165	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AOT18_RS15170	COG2223	nitrite transmembrane transporter activity
AOT18_RS15190	COG1196	nuclear chromosome segregation
AOT18_RS15200	COG0730	response to heat
AOT18_RS15215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOT18_RS15225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT18_RS15280	COG0489	protein tyrosine kinase activity
AOT18_RS15290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT18_RS15290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT18_RS15320	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOT18_RS15325	COG2081	HI0933 family
AOT18_RS15330	COG0668	transmembrane transport
AOT18_RS15350	COG0583	DNA-binding transcription factor activity
AOT18_RS15370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT18_RS15375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOT18_RS15405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOT18_RS15445	COG0745	RESPONSE REGULATOR receiver
AOT18_RS15465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT18_RS15475	COG2205	protein histidine kinase activity
AOT18_RS15545	COG4993	Dehydrogenase
AOT18_RS15565	COG0384	phenazine biosynthesis protein PhzF
AOT18_RS15595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOT18_RS15610	COG0583	DNA-binding transcription factor activity
AOT18_RS15640	COG0583	DNA-binding transcription factor activity
AOT18_RS15660	COG0583	DNA-binding transcription factor activity
AOT18_RS15665	COG1053	succinate dehydrogenase
AOT18_RS15675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOT18_RS15680	COG2814	Major facilitator Superfamily
AOT18_RS15685	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS15690	COG0583	DNA-binding transcription factor activity
AOT18_RS15695	COG1063	alcohol dehydrogenase
AOT18_RS15725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOT18_RS15730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOT18_RS15735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOT18_RS15750	COG3667	copper resistance
AOT18_RS15755	COG2132	Multicopper oxidase
AOT18_RS15765	COG0561	phosphatase activity
AOT18_RS15770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOT18_RS15795	COG1214	PFAM Peptidase M22, glycoprotease
AOT18_RS15875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AOT18_RS15885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOT18_RS15890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOT18_RS15895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOT18_RS15955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT18_RS15965	COG1846	Transcriptional regulator
AOT18_RS15970	COG1764	response to oxidative stress
AOT18_RS16010	COG0037	tRNA processing
AOT18_RS16020	COG0248	Ppx GppA phosphatase
AOT18_RS16045	COG0072	phenylalanine-tRNA ligase activity
AOT18_RS16090	COG1238	metal cluster binding
AOT18_RS16095	COG0625	glutathione transferase activity
AOT18_RS16115	COG0318	PFAM AMP-dependent synthetase and ligase
AOT18_RS16120	COG3028	Belongs to the UPF0307 family
AOT18_RS16125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT18_RS16145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT18_RS16150	COG0617	tRNA 3'-terminal CCA addition
AOT18_RS16155	COG1555	photosystem II stabilization
AOT18_RS16160	COG3956	TIGRFAM MazG family protein
AOT18_RS16170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT18_RS16190	COG2205	protein histidine kinase activity
AOT18_RS16190	COG0784	Response regulator, receiver
AOT18_RS16190	COG5002	protein histidine kinase activity
AOT18_RS16195	COG1024	Enoyl-CoA hydratase
AOT18_RS16200	COG2084	Dehydrogenase
AOT18_RS16205	COG3622	Belongs to the hyi family
AOT18_RS16235	COG0697	spore germination
AOT18_RS16245	COG2814	Major facilitator Superfamily
AOT18_RS16250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT18_RS16260	COG0583	DNA-binding transcription factor activity
AOT18_RS16265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOT18_RS16280	COG0084	hydrolase, TatD family'
AOT18_RS16295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOT18_RS16330	COG0440	acetolactate synthase activity
AOT18_RS16335	COG0028	Belongs to the TPP enzyme family
AOT18_RS16365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT18_RS16370	COG1136	(ABC) transporter
AOT18_RS16370	COG0577	efflux transmembrane transporter activity
AOT18_RS16375	COG1538	Outer membrane efflux protein
AOT18_RS16390	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOT18_RS16395	COG1162	GTPase activity
AOT18_RS16405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOT18_RS16425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT18_RS16430	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS16470	COG2986	histidine ammonia-lyase
AOT18_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
AOT18_RS16495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOT18_RS16540	COG1426	Protein conserved in bacteria
AOT18_RS16575	COG0793	Belongs to the peptidase S41A family
AOT18_RS16590	COG2267	carboxylic ester hydrolase activity
AOT18_RS16600	COG1012	belongs to the aldehyde dehydrogenase family
AOT18_RS16605	COG3265	gluconokinase activity
AOT18_RS16615	COG0800	Aldolase
AOT18_RS16625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT18_RS16630	COG0857	belongs to the CobB CobQ family
AOT18_RS16630	COG0280	phosphate acetyltransferase
AOT18_RS16635	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AOT18_RS16635	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AOT18_RS16655	COG0740	serine-type endopeptidase activity
AOT18_RS16665	COG4774	siderophore transport
AOT18_RS16675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOT18_RS16685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT18_RS16685	COG2813	Specifically methylates the guanine in position
AOT18_RS16785	COG0788	formyltetrahydrofolate deformylase activity
AOT18_RS16810	COG4651	solute:proton antiporter activity
AOT18_RS16810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT18_RS16830	COG0724	RNA recognition motif
AOT18_RS16835	COG0210	DNA helicase
AOT18_RS16860	COG1733	regulation of RNA biosynthetic process
AOT18_RS16870	COG2900	Belongs to the SlyX family
AOT18_RS16875	COG0488	(ABC) transporter
AOT18_RS16880	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS16885	COG1560	Kdo2-lipid A biosynthetic process
AOT18_RS16895	COG1301	dicarboxylic acid transport
AOT18_RS16950	COG0473	3-isopropylmalate dehydrogenase activity
AOT18_RS17015	COG0583	DNA-binding transcription factor activity
AOT18_RS17025	COG0625	glutathione transferase activity
AOT18_RS17030	COG2378	regulation of single-species biofilm formation
AOT18_RS17035	COG0546	phosphoglycolate phosphatase activity
AOT18_RS17050	COG1530	ribonuclease E activity
AOT18_RS17055	COG0318	PFAM AMP-dependent synthetase and ligase
AOT18_RS17070	COG0583	DNA-binding transcription factor activity
AOT18_RS17075	COG4221	oxidoreductase activity
AOT18_RS17080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOT18_RS17090	COG0534	Mate efflux family protein
AOT18_RS17105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT18_RS17140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOT18_RS17145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT18_RS17160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOT18_RS17170	COG0644	oxidoreductase
AOT18_RS17170	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOT18_RS17175	COG0425	Belongs to the sulfur carrier protein TusA family
AOT18_RS17180	COG4535	Mg2 and Co2 transporter CorC
AOT18_RS17190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT18_RS17210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOT18_RS17215	COG0475	glutathione-regulated potassium exporter activity
AOT18_RS17215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT18_RS17220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOT18_RS17230	COG0484	heat shock protein binding
AOT18_RS17235	COG0789	Transcriptional regulator
AOT18_RS17240	COG0598	Magnesium transport protein CorA
AOT18_RS17255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT18_RS17260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT18_RS17265	COG1074	ATP-dependent DNA helicase activity
AOT18_RS17270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOT18_RS17290	COG2226	methyltransferase
AOT18_RS17305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT18_RS17310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOT18_RS17325	COG2111	Na H antiporter
AOT18_RS17325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOT18_RS17330	COG1006	Multisubunit Na H antiporter MnhC subunit
AOT18_RS17335	COG0651	ATP synthesis coupled electron transport
AOT18_RS17340	COG1863	multisubunit Na H antiporter MnhE subunit
AOT18_RS17345	COG2212	antiporter activity
AOT18_RS17350	COG1320	monovalent cation:proton antiporter activity
AOT18_RS17365	COG0195	Participates in both transcription termination and antitermination
AOT18_RS17415	COG0237	dephospho-CoA kinase activity
AOT18_RS17425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT18_RS17440	COG0497	DNA recombination
AOT18_RS17450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOT18_RS17480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOT18_RS17480	COG2169	Transcriptional regulator
AOT18_RS17485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOT18_RS17550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOT18_RS17565	COG0326	Molecular chaperone. Has ATPase activity
AOT18_RS17580	COG2056	Na+-H+ antiporter family
AOT18_RS17585	COG0596	Alpha beta hydrolase
AOT18_RS17680	COG0546	phosphoglycolate phosphatase activity
AOT18_RS17685	COG1716	ATPase activity
AOT18_RS17730	COG0181	hydroxymethylbilane synthase activity
AOT18_RS17740	COG3275	phosphorelay sensor kinase activity
AOT18_RS17760	COG1538	Outer membrane efflux protein
AOT18_RS17765	COG0697	spore germination
AOT18_RS17790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOT18_RS17795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT18_RS17800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT18_RS17805	COG0772	Belongs to the SEDS family
AOT18_RS17830	COG4974	Belongs to the 'phage' integrase family
AOT18_RS17835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT18_RS17845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOT18_RS17855	COG2197	response regulator
AOT18_RS17870	COG0793	Belongs to the peptidase S41A family
AOT18_RS17875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOT18_RS17880	COG0795	lipopolysaccharide-transporting ATPase activity
AOT18_RS17920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT18_RS17920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT18_RS17930	COG0004	ammonium transporteR
AOT18_RS17935	COG0347	Belongs to the P(II) protein family
AOT18_RS17945	COG0606	chelatase, subunit chli
AOT18_RS18000	COG0659	secondary active sulfate transmembrane transporter activity
AOT18_RS18005	COG0589	response to stress
AOT18_RS18050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT18_RS18110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOT18_RS18140	COG0659	secondary active sulfate transmembrane transporter activity
AOT18_RS18145	COG0589	response to stress
AOT18_RS18175	COG0606	chelatase, subunit chli
AOT18_RS18180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT18_RS18190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT18_RS18205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOT18_RS18220	COG0318	PFAM AMP-dependent synthetase and ligase
AOT18_RS18230	COG0477	Major facilitator Superfamily
AOT18_RS18235	COG2860	membrane
AOT18_RS18245	COG1253	flavin adenine dinucleotide binding
AOT18_RS18265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT18_RS18300	COG0655	NAD(P)H dehydrogenase (quinone) activity
AOT18_RS18310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOT18_RS18345	COG1309	transcriptional regulator
AOT18_RS18380	COG0758	DNA mediated transformation
AOT18_RS18390	COG0697	spore germination
AOT18_RS18395	COG1309	transcriptional regulator
AOT18_RS18410	COG0386	Belongs to the glutathione peroxidase family
AOT18_RS18475	COG1121	(ABC) transporter
AOT18_RS18480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOT18_RS18485	COG1280	lysine exporter protein (LysE YggA)
AOT18_RS18490	COG2837	iron assimilation
AOT18_RS18500	COG0281	malic enzyme
AOT18_RS18545	COG0519	Catalyzes the synthesis of GMP from XMP
AOT18_RS18545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT18_RS18550	COG4399	Belongs to the UPF0754 family
AOT18_RS18555	COG2259	Doxx family
AOT18_RS18560	COG0586	Pfam SNARE associated Golgi protein
AOT18_RS18575	COG1192	Involved in chromosome partitioning
AOT18_RS18585	COG0271	Belongs to the BolA IbaG family
AOT18_RS18605	COG2267	carboxylic ester hydrolase activity
AOT18_RS18625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT18_RS18625	COG3321	synthase
AOT18_RS18625	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AOT18_RS18625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOT18_RS18630	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS18640	COG2197	response regulator
AOT18_RS18650	COG3916	Acyl-homoserine-lactone synthase
AOT18_RS18655	COG0477	Major facilitator Superfamily
AOT18_RS18660	COG1024	Enoyl-CoA hydratase
AOT18_RS18665	COG1024	Enoyl-CoA hydratase
AOT18_RS18670	COG1960	acyl-CoA dehydrogenase activity
AOT18_RS18695	COG1113	amino acid transport
AOT18_RS18700	COG1113	amino acid transport
AOT18_RS18705	COG0251	oxidation-reduction process
AOT18_RS18745	COG0564	pseudouridine synthase activity
AOT18_RS18810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOT18_RS18825	COG1802	Transcriptional regulator
AOT18_RS18830	COG1448	Aminotransferase
AOT18_RS18835	COG0277	FAD linked oxidase domain protein
AOT18_RS18845	COG2186	Transcriptional regulator
AOT18_RS18855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT18_RS18860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT18_RS18875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOT18_RS18880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT18_RS18885	COG1216	Glycosyl transferase, family 2
AOT18_RS18915	COG2089	acid synthase
AOT18_RS18930	COG1083	cytidylyl-transferase
AOT18_RS18935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOT18_RS18940	COG1086	Polysaccharide biosynthesis protein
AOT18_RS18945	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOT18_RS18950	COG1596	polysaccharide export
AOT18_RS18975	COG0728	peptidoglycan biosynthetic process
AOT18_RS18980	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT18_RS19035	COG0546	phosphoglycolate phosphatase activity
AOT18_RS19040	COG1028	Short-chain dehydrogenase reductase Sdr
AOT18_RS19060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT18_RS19065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT18_RS19070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT18_RS19075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOT18_RS19080	COG1116	anion transmembrane transporter activity
AOT18_RS19085	COG1309	transcriptional regulator
AOT18_RS19090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOT18_RS19100	COG0196	riboflavin kinase activity
AOT18_RS19105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOT18_RS19115	COG1047	Peptidyl-prolyl cis-trans
AOT18_RS19155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOT18_RS19160	COG0657	acetylesterase activity
AOT18_RS19180	COG0583	DNA-binding transcription factor activity
AOT18_RS19210	COG2951	lytic endotransglycosylase activity
AOT18_RS19215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AOT18_RS19235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT18_RS19245	COG0671	phosphoesterase, PA-phosphatase related
AOT18_RS19250	COG0861	Integral membrane protein TerC family
AOT18_RS19260	COG0754	glutathionylspermidine amidase activity
AOT18_RS19270	COG0402	S-adenosylhomocysteine deaminase activity
AOT18_RS19285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT18_RS19290	COG1230	cation diffusion facilitator family transporter
AOT18_RS19305	COG0706	membrane insertase activity
AOT18_RS19615	COG0656	L-ascorbic acid biosynthetic process
AOT18_RS19820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT18_RS19975	COG0488	(ABC) transporter
AOT18_RS20345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT18_RS20350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT18_RS20385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)