locus-tag	class	description
KPZ59_RS00005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KPZ59_RS00010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KPZ59_RS00015	COG0596	Alpha beta hydrolase
KPZ59_RS00040	COG0488	(ABC) transporter
KPZ59_RS00045	COG0586	Pfam SNARE associated Golgi protein
KPZ59_RS00055	COG0187	DNA topoisomerase II activity
KPZ59_RS00065	COG0592	DNA-directed DNA polymerase activity
KPZ59_RS00095	COG0706	membrane insertase activity
KPZ59_RS00110	COG1230	cation diffusion facilitator family transporter
KPZ59_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_RS00130	COG0402	S-adenosylhomocysteine deaminase activity
KPZ59_RS00140	COG0754	glutathionylspermidine amidase activity
KPZ59_RS00150	COG0861	Integral membrane protein TerC family
KPZ59_RS00155	COG0671	phosphoesterase, PA-phosphatase related
KPZ59_RS00165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KPZ59_RS00180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KPZ59_RS00185	COG2951	lytic endotransglycosylase activity
KPZ59_RS00215	COG0583	DNA-binding transcription factor activity
KPZ59_RS00235	COG0657	acetylesterase activity
KPZ59_RS00240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KPZ59_RS00280	COG1047	Peptidyl-prolyl cis-trans
KPZ59_RS00290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KPZ59_RS00295	COG0196	riboflavin kinase activity
KPZ59_RS00305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KPZ59_RS00310	COG1309	transcriptional regulator
KPZ59_RS00315	COG1116	anion transmembrane transporter activity
KPZ59_RS00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_RS00325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS00330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_RS00335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS00360	COG0546	phosphoglycolate phosphatase activity
KPZ59_RS00415	COG3023	N-Acetylmuramoyl-L-alanine amidase
KPZ59_RS00420	COG0728	peptidoglycan biosynthetic process
KPZ59_RS00445	COG1596	polysaccharide export
KPZ59_RS00450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KPZ59_RS00460	COG1216	Glycosyl transferase, family 2
KPZ59_RS00460	COG1442	glycosyl transferase family 8
KPZ59_RS00470	COG1216	Glycosyl transferase, family 2
KPZ59_RS00480	COG1216	Glycosyl transferase, family 2
KPZ59_RS00485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KPZ59_RS00490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KPZ59_RS00505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KPZ59_RS00515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPZ59_RS00525	COG2186	Transcriptional regulator
KPZ59_RS00535	COG0277	FAD linked oxidase domain protein
KPZ59_RS00540	COG1448	Aminotransferase
KPZ59_RS00550	COG1802	Transcriptional regulator
KPZ59_RS00565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KPZ59_RS00660	COG0564	pseudouridine synthase activity
KPZ59_RS00700	COG0251	oxidation-reduction process
KPZ59_RS00705	COG1113	amino acid transport
KPZ59_RS00710	COG1113	amino acid transport
KPZ59_RS00730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_RS00735	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS00740	COG1024	Enoyl-CoA hydratase
KPZ59_RS00745	COG1024	Enoyl-CoA hydratase
KPZ59_RS00750	COG0477	Major facilitator Superfamily
KPZ59_RS00755	COG3916	Acyl-homoserine-lactone synthase
KPZ59_RS00765	COG2197	response regulator
KPZ59_RS00775	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS00780	COG3321	synthase
KPZ59_RS00780	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KPZ59_RS00780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KPZ59_RS00780	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KPZ59_RS00820	COG0271	Belongs to the BolA IbaG family
KPZ59_RS00830	COG1192	Involved in chromosome partitioning
KPZ59_RS00845	COG0586	Pfam SNARE associated Golgi protein
KPZ59_RS00850	COG2259	Doxx family
KPZ59_RS00855	COG4399	Belongs to the UPF0754 family
KPZ59_RS00860	COG0519	Catalyzes the synthesis of GMP from XMP
KPZ59_RS00860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KPZ59_RS00905	COG0281	malic enzyme
KPZ59_RS00910	COG2837	iron assimilation
KPZ59_RS00915	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS00920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KPZ59_RS00925	COG1121	(ABC) transporter
KPZ59_RS00990	COG0386	Belongs to the glutathione peroxidase family
KPZ59_RS01005	COG1309	transcriptional regulator
KPZ59_RS01010	COG0697	spore germination
KPZ59_RS01020	COG0758	DNA mediated transformation
KPZ59_RS01090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KPZ59_RS01100	COG0655	NAD(P)H dehydrogenase (quinone) activity
KPZ59_RS01140	COG4452	Inner membrane protein CreD
KPZ59_RS01145	COG2205	protein histidine kinase activity
KPZ59_RS01150	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS01155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_RS01165	COG0477	Major facilitator Superfamily
KPZ59_RS01175	COG1253	flavin adenine dinucleotide binding
KPZ59_RS01180	COG3012	SEC-C Motif Domain Protein
KPZ59_RS01185	COG2860	membrane
KPZ59_RS01190	COG0477	Major facilitator Superfamily
KPZ59_RS01200	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_RS01215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KPZ59_RS01230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_RS01245	COG0606	chelatase, subunit chli
KPZ59_RS01255	COG0347	Belongs to the P(II) protein family
KPZ59_RS01260	COG0004	ammonium transporteR
KPZ59_RS01270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPZ59_RS01270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KPZ59_RS01310	COG0795	lipopolysaccharide-transporting ATPase activity
KPZ59_RS01315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KPZ59_RS01320	COG0793	Belongs to the peptidase S41A family
KPZ59_RS01335	COG2197	response regulator
KPZ59_RS01345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KPZ59_RS01355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_RS01360	COG4974	Belongs to the 'phage' integrase family
KPZ59_RS01385	COG0772	Belongs to the SEDS family
KPZ59_RS01390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPZ59_RS01395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KPZ59_RS01405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KPZ59_RS01430	COG0697	spore germination
KPZ59_RS01435	COG1538	Outer membrane efflux protein
KPZ59_RS01455	COG3275	phosphorelay sensor kinase activity
KPZ59_RS01465	COG0181	hydroxymethylbilane synthase activity
KPZ59_RS01510	COG1716	ATPase activity
KPZ59_RS01515	COG0546	phosphoglycolate phosphatase activity
KPZ59_RS01615	COG2056	Na+-H+ antiporter family
KPZ59_RS01630	COG0326	Molecular chaperone. Has ATPase activity
KPZ59_RS01645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KPZ59_RS01715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KPZ59_RS01720	COG2169	Transcriptional regulator
KPZ59_RS01720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KPZ59_RS01750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KPZ59_RS01760	COG0497	DNA recombination
KPZ59_RS01775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KPZ59_RS01785	COG0237	dephospho-CoA kinase activity
KPZ59_RS01835	COG0195	Participates in both transcription termination and antitermination
KPZ59_RS01850	COG1320	monovalent cation:proton antiporter activity
KPZ59_RS01855	COG2212	antiporter activity
KPZ59_RS01860	COG1863	multisubunit Na H antiporter MnhE subunit
KPZ59_RS01865	COG0651	ATP synthesis coupled electron transport
KPZ59_RS01870	COG1006	Multisubunit Na H antiporter MnhC subunit
KPZ59_RS01875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KPZ59_RS01875	COG2111	Na H antiporter
KPZ59_RS01890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KPZ59_RS01905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS01920	COG2226	methyltransferase
KPZ59_RS01940	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KPZ59_RS01945	COG1074	ATP-dependent DNA helicase activity
KPZ59_RS01950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPZ59_RS01955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KPZ59_RS01970	COG0598	Magnesium transport protein CorA
KPZ59_RS01975	COG0789	Transcriptional regulator
KPZ59_RS01980	COG0484	heat shock protein binding
KPZ59_RS01995	COG0475	glutathione-regulated potassium exporter activity
KPZ59_RS01995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPZ59_RS02000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KPZ59_RS02020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_RS02030	COG4535	Mg2 and Co2 transporter CorC
KPZ59_RS02035	COG0425	Belongs to the sulfur carrier protein TusA family
KPZ59_RS02045	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KPZ59_RS02045	COG0644	oxidoreductase
KPZ59_RS02055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KPZ59_RS02070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_RS02075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KPZ59_RS02085	COG0493	'glutamate synthase
KPZ59_RS02085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_RS02115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KPZ59_RS02130	COG0534	Mate efflux family protein
KPZ59_RS02140	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KPZ59_RS02145	COG4221	oxidoreductase activity
KPZ59_RS02150	COG0583	DNA-binding transcription factor activity
KPZ59_RS02165	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_RS02170	COG1530	ribonuclease E activity
KPZ59_RS02180	COG0546	phosphoglycolate phosphatase activity
KPZ59_RS02185	COG2378	regulation of single-species biofilm formation
KPZ59_RS02190	COG0625	glutathione transferase activity
KPZ59_RS02200	COG0583	DNA-binding transcription factor activity
KPZ59_RS02255	COG0473	3-isopropylmalate dehydrogenase activity
KPZ59_RS02310	COG1301	dicarboxylic acid transport
KPZ59_RS02320	COG1560	Kdo2-lipid A biosynthetic process
KPZ59_RS02325	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS02345	COG0488	(ABC) transporter
KPZ59_RS02350	COG2900	Belongs to the SlyX family
KPZ59_RS02360	COG1733	regulation of RNA biosynthetic process
KPZ59_RS02385	COG0210	DNA helicase
KPZ59_RS02390	COG0724	RNA recognition motif
KPZ59_RS02410	COG4651	solute:proton antiporter activity
KPZ59_RS02410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KPZ59_RS02435	COG0788	formyltetrahydrofolate deformylase activity
KPZ59_RS02545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_RS02545	COG2813	Specifically methylates the guanine in position
KPZ59_RS02555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KPZ59_RS02565	COG4774	siderophore transport
KPZ59_RS02575	COG0740	serine-type endopeptidase activity
KPZ59_RS02595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KPZ59_RS02595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KPZ59_RS02600	COG0280	phosphate acetyltransferase
KPZ59_RS02600	COG0857	belongs to the CobB CobQ family
KPZ59_RS02605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KPZ59_RS02615	COG0800	Aldolase
KPZ59_RS02625	COG3265	gluconokinase activity
KPZ59_RS02630	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS02640	COG2267	carboxylic ester hydrolase activity
KPZ59_RS02655	COG0793	Belongs to the peptidase S41A family
KPZ59_RS02690	COG1426	Protein conserved in bacteria
KPZ59_RS02730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KPZ59_RS02740	COG1162	GTPase activity
KPZ59_RS02745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KPZ59_RS02760	COG1538	Outer membrane efflux protein
KPZ59_RS02765	COG0577	efflux transmembrane transporter activity
KPZ59_RS02765	COG1136	(ABC) transporter
KPZ59_RS02770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS02795	COG0028	Belongs to the TPP enzyme family
KPZ59_RS02800	COG0440	acetolactate synthase activity
KPZ59_RS02855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KPZ59_RS02870	COG0084	hydrolase, TatD family'
KPZ59_RS02885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KPZ59_RS02895	COG0583	DNA-binding transcription factor activity
KPZ59_RS02905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPZ59_RS02995	COG2205	protein histidine kinase activity
KPZ59_RS03020	COG0789	Transcriptional regulator
KPZ59_RS03055	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_RS03070	COG0640	Transcriptional regulator
KPZ59_RS03080	COG0798	PFAM Bile acid sodium symporter
KPZ59_RS03085	COG0431	NADPH-dependent FMN reductase
KPZ59_RS03100	COG2814	Major facilitator Superfamily
KPZ59_RS03110	COG0697	spore germination
KPZ59_RS03140	COG3622	Belongs to the hyi family
KPZ59_RS03145	COG2084	Dehydrogenase
KPZ59_RS03150	COG1024	Enoyl-CoA hydratase
KPZ59_RS03155	COG0784	Response regulator, receiver
KPZ59_RS03155	COG5002	protein histidine kinase activity
KPZ59_RS03155	COG2205	protein histidine kinase activity
KPZ59_RS03175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPZ59_RS03185	COG3956	TIGRFAM MazG family protein
KPZ59_RS03190	COG1555	photosystem II stabilization
KPZ59_RS03195	COG0617	tRNA 3'-terminal CCA addition
KPZ59_RS03200	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KPZ59_RS03220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KPZ59_RS03225	COG3028	Belongs to the UPF0307 family
KPZ59_RS03230	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_RS03245	COG0625	glutathione transferase activity
KPZ59_RS03250	COG1238	metal cluster binding
KPZ59_RS03290	COG0072	phenylalanine-tRNA ligase activity
KPZ59_RS03320	COG0248	Ppx GppA phosphatase
KPZ59_RS03330	COG0037	tRNA processing
KPZ59_RS03370	COG1764	response to oxidative stress
KPZ59_RS03375	COG1846	Transcriptional regulator
KPZ59_RS03385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPZ59_RS03445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KPZ59_RS03450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KPZ59_RS03455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KPZ59_RS03465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KPZ59_RS03480	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS03525	COG1214	PFAM Peptidase M22, glycoprotease
KPZ59_RS03540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KPZ59_RS03550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KPZ59_RS03555	COG0561	phosphatase activity
KPZ59_RS03565	COG2132	Multicopper oxidase
KPZ59_RS03585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KPZ59_RS03590	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KPZ59_RS03595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KPZ59_RS03625	COG1063	alcohol dehydrogenase
KPZ59_RS03630	COG0583	DNA-binding transcription factor activity
KPZ59_RS03635	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS03640	COG2814	Major facilitator Superfamily
KPZ59_RS03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KPZ59_RS03655	COG1053	succinate dehydrogenase
KPZ59_RS03660	COG0583	DNA-binding transcription factor activity
KPZ59_RS03675	COG0583	DNA-binding transcription factor activity
KPZ59_RS03705	COG0583	DNA-binding transcription factor activity
KPZ59_RS03720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS03725	COG1309	transcriptional regulator
KPZ59_RS03745	COG0384	phenazine biosynthesis protein PhzF
KPZ59_RS03760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KPZ59_RS03780	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS03820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KPZ59_RS03850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KPZ59_RS03855	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KPZ59_RS03875	COG0583	DNA-binding transcription factor activity
KPZ59_RS03895	COG0668	transmembrane transport
KPZ59_RS03905	COG2081	HI0933 family
KPZ59_RS03910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KPZ59_RS03940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_RS03940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KPZ59_RS03950	COG0489	protein tyrosine kinase activity
KPZ59_RS04005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KPZ59_RS04015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KPZ59_RS04030	COG0730	response to heat
KPZ59_RS04040	COG1196	nuclear chromosome segregation
KPZ59_RS04060	COG2223	nitrite transmembrane transporter activity
KPZ59_RS04065	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KPZ59_RS04070	COG1877	trehalose-phosphatase activity
KPZ59_RS04075	COG2226	methyltransferase
KPZ59_RS04075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_RS04075	COG0596	Alpha beta hydrolase
KPZ59_RS04090	COG4106	trans-aconitate 2-methyltransferase activity
KPZ59_RS04105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KPZ59_RS04110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KPZ59_RS04115	COG0009	L-threonylcarbamoyladenylate synthase
KPZ59_RS04120	COG3101	peptidyl-lysine hydroxylation
KPZ59_RS04125	COG1399	metal-binding, possibly nucleic acid-binding protein
KPZ59_RS04150	COG1652	LysM domain
KPZ59_RS04155	COG0351	phosphomethylpyrimidine kinase
KPZ59_RS04155	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_RS04155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KPZ59_RS04165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KPZ59_RS04195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KPZ59_RS04225	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KPZ59_RS04240	COG0358	DNA primase activity
KPZ59_RS04250	COG0564	pseudouridine synthase activity
KPZ59_RS04315	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_RS04370	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_RS04455	COG5410	chromosome segregation
KPZ59_RS04460	COG3567	Phage-associated protein, HI1409 family
KPZ59_RS04485	COG3566	protein conserved in bacteria
KPZ59_RS04605	COG0582	viral genome integration into host DNA
KPZ59_RS04615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_RS04635	COG0583	DNA-binding transcription factor activity
KPZ59_RS04640	COG0473	3-isopropylmalate dehydrogenase activity
KPZ59_RS04650	COG0657	acetylesterase activity
KPZ59_RS04660	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS04680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KPZ59_RS04680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KPZ59_RS04695	COG1981	membrane
KPZ59_RS04740	COG0456	acetyltransferase
KPZ59_RS04750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KPZ59_RS04755	COG0492	ferredoxin-NADP+ reductase activity
KPZ59_RS04760	COG1674	ftsk spoiiie
KPZ59_RS04760	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KPZ59_RS04765	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS04785	COG2894	cell division
KPZ59_RS04800	COG0204	Acyl-transferase
KPZ59_RS04805	COG2885	chlorophyll binding
KPZ59_RS04810	COG0210	DNA helicase
KPZ59_RS04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KPZ59_RS04835	COG0121	glutamine amidotransferase
KPZ59_RS04855	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KPZ59_RS04860	COG0735	belongs to the Fur family
KPZ59_RS04885	COG0420	3'-5' exonuclease activity
KPZ59_RS04905	COG1090	epimerase
KPZ59_RS04920	COG2050	protein possibly involved in aromatic compounds catabolism
KPZ59_RS04930	COG2814	Major facilitator Superfamily
KPZ59_RS04935	COG0405	Gamma-glutamyltransferase
KPZ59_RS05005	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
KPZ59_RS05015	COG0477	Major facilitator Superfamily
KPZ59_RS05020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_RS05030	COG1595	DNA-templated transcription, initiation
KPZ59_RS05085	COG0531	amino acid
KPZ59_RS05090	COG2040	homocysteine
KPZ59_RS05115	COG1309	transcriptional regulator
KPZ59_RS05120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_RS05125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_RS05135	COG1607	acyl-coa hydrolase
KPZ59_RS05145	COG0523	cobalamin synthesis protein
KPZ59_RS05155	COG4681	YaeQ
KPZ59_RS05165	COG0726	polysaccharide deacetylase
KPZ59_RS05165	COG1649	PFAM Uncharacterised BCR, COG1649
KPZ59_RS05170	COG1215	transferase activity, transferring glycosyl groups
KPZ59_RS05180	COG1024	Enoyl-CoA hydratase
KPZ59_RS05195	COG1414	Transcriptional regulator
KPZ59_RS05215	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS05230	COG2271	Major facilitator Superfamily
KPZ59_RS05240	COG2267	carboxylic ester hydrolase activity
KPZ59_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS05260	COG0028	Belongs to the TPP enzyme family
KPZ59_RS05270	COG0477	Major facilitator Superfamily
KPZ59_RS05275	COG0242	peptide deformylase activity
KPZ59_RS05280	COG2066	Belongs to the glutaminase family
KPZ59_RS05285	COG2207	Transcriptional regulator
KPZ59_RS05290	COG2223	nitrite transmembrane transporter activity
KPZ59_RS05305	COG0583	DNA-binding transcription factor activity
KPZ59_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS05315	COG2271	Major facilitator Superfamily
KPZ59_RS05320	COG3959	Transketolase, thiamine diphosphate binding domain
KPZ59_RS05325	COG3958	Transketolase
KPZ59_RS05335	COG0306	phosphate transporter
KPZ59_RS05355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_RS05400	COG4181	ATPase activity
KPZ59_RS05405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KPZ59_RS05435	COG0583	DNA-binding transcription factor activity
KPZ59_RS05445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_RS05450	COG1773	rubredoxin
KPZ59_RS05500	COG2851	Citrate transporter
KPZ59_RS05505	COG1253	flavin adenine dinucleotide binding
KPZ59_RS05545	COG0804	urea catabolic process
KPZ59_RS05555	COG0830	nickel cation binding
KPZ59_RS05570	COG0742	ribosomal rna small subunit methyltransferase
KPZ59_RS05575	COG0768	penicillin binding
KPZ59_RS05600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KPZ59_RS05605	COG2878	Part of a membrane complex involved in electron transport
KPZ59_RS05610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KPZ59_RS05620	COG3384	dioxygenase
KPZ59_RS05635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KPZ59_RS05675	COG0006	proline dipeptidase activity
KPZ59_RS05680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS05685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS05705	COG1279	arginine transmembrane transporter activity
KPZ59_RS05710	COG0583	DNA-binding transcription factor activity
KPZ59_RS05750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_RS05755	COG1388	LysM domain
KPZ59_RS05755	COG0741	lytic transglycosylase activity
KPZ59_RS05755	COG1388	LysM domain
KPZ59_RS05755	COG0741	lytic transglycosylase activity
KPZ59_RS05765	COG4174	ABC transporter (Permease)
KPZ59_RS05770	COG4239	(ABC) transporter, permease
KPZ59_RS05775	COG4172	Belongs to the ABC transporter superfamily
KPZ59_RS05795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_RS05805	COG5001	Diguanylate cyclase
KPZ59_RS05805	COG4251	negative regulation of phosphorylation
KPZ59_RS05805	COG3706	GGDEF domain
KPZ59_RS05805	COG2203	Gaf domain
KPZ59_RS05820	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_RS05820	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_RS05850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_RS05860	COG0583	DNA-binding transcription factor activity
KPZ59_RS05865	COG2814	Major facilitator Superfamily
KPZ59_RS05880	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS05885	COG1454	alcohol dehydrogenase
KPZ59_RS05890	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_RS05905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_RS05910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_RS05915	COG0183	Belongs to the thiolase family
KPZ59_RS05950	COG1113	amino acid transport
KPZ59_RS05960	COG0531	amino acid
KPZ59_RS05980	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS06000	COG1113	amino acid transport
KPZ59_RS06015	COG0697	spore germination
KPZ59_RS06020	COG2721	sulfolactate sulfo-lyase activity
KPZ59_RS06025	COG2271	Major facilitator Superfamily
KPZ59_RS06030	COG4948	Mandelate Racemase Muconate Lactonizing
KPZ59_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS06045	COG2186	Transcriptional regulator
KPZ59_RS06070	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS06080	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS06085	COG1024	Enoyl-CoA hydratase
KPZ59_RS06090	COG2814	Major facilitator Superfamily
KPZ59_RS06105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_RS06120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KPZ59_RS06160	COG2207	Transcriptional regulator
KPZ59_RS06165	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KPZ59_RS06170	COG2072	flavoprotein involved in K transport
KPZ59_RS06175	COG0300	oxidoreductase activity
KPZ59_RS06185	COG1309	transcriptional regulator
KPZ59_RS06190	COG1741	Belongs to the pirin family
KPZ59_RS06205	COG2072	flavoprotein involved in K transport
KPZ59_RS06215	COG2252	PERMEase
KPZ59_RS06220	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KPZ59_RS06225	COG3038	cytochrome b561
KPZ59_RS06235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KPZ59_RS06245	COG0527	aspartate kinase activity
KPZ59_RS06440	COG5410	chromosome segregation
KPZ59_RS06655	COG0582	viral genome integration into host DNA
KPZ59_RS06665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KPZ59_RS06675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KPZ59_RS06690	COG0667	Aldo Keto reductase
KPZ59_RS06705	COG1765	OsmC-like protein
KPZ59_RS06720	COG0542	response to heat
KPZ59_RS06755	COG2885	chlorophyll binding
KPZ59_RS06765	COG0625	glutathione transferase activity
KPZ59_RS06770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KPZ59_RS06790	COG3634	alkyl hydroperoxide reductase activity
KPZ59_RS06800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
KPZ59_RS06810	COG0450	alkyl hydroperoxide reductase
KPZ59_RS06815	COG1643	Atp-dependent helicase
KPZ59_RS06830	COG2814	Major facilitator Superfamily
KPZ59_RS06835	COG3135	benzoate transporter
KPZ59_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS06845	COG0543	2 iron, 2 sulfur cluster binding
KPZ59_RS06845	COG0633	Ferredoxin
KPZ59_RS06855	COG4638	Rieske (2fe-2S)
KPZ59_RS06865	COG0583	DNA-binding transcription factor activity
KPZ59_RS06875	COG2871	sodium ion transport
KPZ59_RS06955	COG1570	exodeoxyribonuclease VII activity
KPZ59_RS06985	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS06990	COG1278	Cold shock
KPZ59_RS07015	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS07030	COG2814	Major facilitator Superfamily
KPZ59_RS07100	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KPZ59_RS07110	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KPZ59_RS07115	COG1137	ATPase activity
KPZ59_RS07120	COG1538	Outer membrane efflux protein
KPZ59_RS07150	COG4122	O-methyltransferase activity
KPZ59_RS07160	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KPZ59_RS07175	COG1522	sequence-specific DNA binding
KPZ59_RS07180	COG5006	permease, DMT superfamily
KPZ59_RS07190	COG1560	Kdo2-lipid A biosynthetic process
KPZ59_RS07195	COG0598	Magnesium transport protein CorA
KPZ59_RS07215	COG2814	Major facilitator Superfamily
KPZ59_RS07235	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_RS07255	COG0583	DNA-binding transcription factor activity
KPZ59_RS07260	COG1914	H( )-stimulated, divalent metal cation uptake system
KPZ59_RS07280	COG4770	biotin carboxylase activity
KPZ59_RS07285	COG0038	chloride channel
KPZ59_RS07290	COG2831	hemolysin activation secretion protein
KPZ59_RS07295	COG3210	domain, Protein
KPZ59_RS07305	COG1309	transcriptional regulator
KPZ59_RS07315	COG1063	alcohol dehydrogenase
KPZ59_RS07330	COG0439	Biotin carboxylase
KPZ59_RS07335	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_RS07340	COG1733	regulation of RNA biosynthetic process
KPZ59_RS07350	COG0864	Transcriptional regulator
KPZ59_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_RS07365	COG1116	anion transmembrane transporter activity
KPZ59_RS07525	COG0590	tRNA wobble adenosine to inosine editing
KPZ59_RS07530	COG2807	transmembrane transport
KPZ59_RS07545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KPZ59_RS07555	COG0789	Transcriptional regulator
KPZ59_RS07565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_RS07585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KPZ59_RS07610	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS07615	COG0531	amino acid
KPZ59_RS07620	COG1760	l-serine dehydratase
KPZ59_RS07625	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS07625	COG2030	dehydratase
KPZ59_RS07630	COG3396	Phenylacetate-CoA oxygenase
KPZ59_RS07635	COG3460	Phenylacetate-CoA oxygenase
KPZ59_RS07640	COG3396	Phenylacetate-CoA oxygenase
KPZ59_RS07645	COG2151	metal-sulfur cluster biosynthetic enzyme
KPZ59_RS07650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_RS07655	COG1024	Enoyl-CoA hydratase
KPZ59_RS07660	COG1024	Enoyl-CoA hydratase
KPZ59_RS07665	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_RS07670	COG0183	Belongs to the thiolase family
KPZ59_RS07675	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KPZ59_RS07680	COG3327	negative regulation of DNA-templated transcription, initiation
KPZ59_RS07690	COG2050	protein possibly involved in aromatic compounds catabolism
KPZ59_RS07700	COG0556	nucleotide-excision repair
KPZ59_RS07725	COG2207	Transcriptional regulator
KPZ59_RS07745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KPZ59_RS07750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KPZ59_RS07755	COG2271	Major facilitator Superfamily
KPZ59_RS07760	COG0753	catalase activity
KPZ59_RS07765	COG3038	cytochrome b561
KPZ59_RS07785	COG2267	carboxylic ester hydrolase activity
KPZ59_RS07790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS07795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS07800	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS07810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KPZ59_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS07825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPZ59_RS07830	COG0583	DNA-binding transcription factor activity
KPZ59_RS07840	COG1414	Transcriptional regulator
KPZ59_RS07845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS07855	COG1840	ABC-type Fe3 transport system, periplasmic component
KPZ59_RS07860	COG3842	ATPase activity
KPZ59_RS07875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KPZ59_RS07880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPZ59_RS07885	COG2814	Major facilitator Superfamily
KPZ59_RS07890	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS07905	COG1024	Enoyl-CoA hydratase
KPZ59_RS07915	COG2814	Major facilitator Superfamily
KPZ59_RS07925	COG0183	Belongs to the thiolase family
KPZ59_RS07930	COG1250	3-hydroxyacyl-CoA dehydrogenase
KPZ59_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS07940	COG1024	Enoyl-CoA hydratase
KPZ59_RS07945	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS07950	COG2814	Major facilitator Superfamily
KPZ59_RS07955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_RS07960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_RS07970	COG2814	Major facilitator Superfamily
KPZ59_RS07980	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS07995	COG0583	DNA-binding transcription factor activity
KPZ59_RS08005	COG4770	biotin carboxylase activity
KPZ59_RS08010	COG1024	Enoyl-CoA hydratase
KPZ59_RS08015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KPZ59_RS08020	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS08025	COG1309	transcriptional regulator
KPZ59_RS08030	COG0318	PFAM AMP-dependent synthetase and ligase
KPZ59_RS08050	COG0583	DNA-binding transcription factor activity
KPZ59_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS08130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KPZ59_RS08150	COG0784	Response regulator, receiver
KPZ59_RS08150	COG2205	protein histidine kinase activity
KPZ59_RS08190	COG0765	amino acid transport
KPZ59_RS08195	COG0765	amino acid transport
KPZ59_RS08205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KPZ59_RS08225	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS08230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KPZ59_RS08235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPZ59_RS08240	COG1045	serine acetyltransferase
KPZ59_RS08255	COG0583	DNA-binding transcription factor activity
KPZ59_RS08260	COG0625	glutathione transferase activity
KPZ59_RS08265	COG0625	glutathione transferase activity
KPZ59_RS08270	COG0583	DNA-binding transcription factor activity
KPZ59_RS08280	COG1346	cytolysis
KPZ59_RS08305	COG0300	oxidoreductase activity
KPZ59_RS08315	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
KPZ59_RS08320	COG3052	prosthetic group binding
KPZ59_RS08340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KPZ59_RS08360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_RS08370	COG1294	oxidase, subunit
KPZ59_RS08375	COG1271	oxidase subunit
KPZ59_RS08395	COG0477	Major facilitator Superfamily
KPZ59_RS08405	COG4521	taurine ABC transporter
KPZ59_RS08410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KPZ59_RS08415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_RS08420	COG2175	clavaminate synthase activity
KPZ59_RS08430	COG1953	Uracil, thiamine, allantoin
KPZ59_RS08440	COG0583	DNA-binding transcription factor activity
KPZ59_RS08450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KPZ59_RS08465	COG0640	Transcriptional regulator
KPZ59_RS08470	COG0798	PFAM Bile acid sodium symporter
KPZ59_RS08475	COG0583	DNA-binding transcription factor activity
KPZ59_RS08490	COG3634	alkyl hydroperoxide reductase activity
KPZ59_RS08530	COG0436	Aminotransferase
KPZ59_RS08540	COG0386	Belongs to the glutathione peroxidase family
KPZ59_RS08580	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KPZ59_RS08605	COG0012	GTP binding
KPZ59_RS08610	COG2011	ABC-type metal ion transport system permease component
KPZ59_RS08615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KPZ59_RS08625	COG1464	Belongs to the NlpA lipoprotein family
KPZ59_RS08655	COG0765	amino acid transport
KPZ59_RS08660	COG0765	amino acid transport
KPZ59_RS08665	COG1126	abc transporter atp-binding protein
KPZ59_RS08675	COG1522	sequence-specific DNA binding
KPZ59_RS08690	COG1309	transcriptional regulator
KPZ59_RS08705	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS08715	COG0583	DNA-binding transcription factor activity
KPZ59_RS08725	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KPZ59_RS08735	COG0697	spore germination
KPZ59_RS08760	COG3121	Chaperone
KPZ59_RS08765	COG3539	Fimbrial protein
KPZ59_RS08790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KPZ59_RS08790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KPZ59_RS08835	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KPZ59_RS08845	COG2353	YceI-like domain
KPZ59_RS08855	COG3698	Phosphodiester glycosidase
KPZ59_RS08870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KPZ59_RS08875	COG0506	proline dehydrogenase activity
KPZ59_RS08875	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KPZ59_RS08875	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
KPZ59_RS08885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KPZ59_RS08890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KPZ59_RS08910	COG1132	(ABC) transporter
KPZ59_RS08915	COG3122	Protein conserved in bacteria
KPZ59_RS08920	COG3619	membrane
KPZ59_RS08935	COG0640	Transcriptional regulator
KPZ59_RS08945	COG2850	peptidyl-arginine hydroxylation
KPZ59_RS08950	COG0424	maF-like protein
KPZ59_RS08970	COG0191	fructose-bisphosphate aldolase activity
KPZ59_RS08975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPZ59_RS08990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KPZ59_RS09000	COG1192	Involved in chromosome partitioning
KPZ59_RS09005	COG1475	DNA binding
KPZ59_RS09010	COG0811	peptide transport
KPZ59_RS09020	COG1132	(ABC) transporter
KPZ59_RS09025	COG1663	tetraacyldisaccharide 4'-kinase activity
KPZ59_RS09045	COG0084	hydrolase, TatD family'
KPZ59_RS09110	COG0776	regulation of translation
KPZ59_RS09140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KPZ59_RS09145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KPZ59_RS09185	COG4166	transmembrane transport
KPZ59_RS09195	COG0339	signal peptide processing
KPZ59_RS09205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KPZ59_RS09240	COG0702	epimerase
KPZ59_RS09245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KPZ59_RS09265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KPZ59_RS09295	COG0316	Belongs to the HesB IscA family
KPZ59_RS09300	COG0822	iron-sulfur transferase activity
KPZ59_RS09325	COG0776	regulation of translation
KPZ59_RS09330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KPZ59_RS09335	COG2207	Transcriptional regulator
KPZ59_RS09340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_RS09345	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS09350	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS09365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KPZ59_RS09385	COG4264	IucA IucC family
KPZ59_RS09390	COG4264	IucA IucC family
KPZ59_RS09400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KPZ59_RS09430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KPZ59_RS09445	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KPZ59_RS09450	COG0406	alpha-ribazole phosphatase activity
KPZ59_RS09465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
KPZ59_RS09470	COG0730	response to heat
KPZ59_RS09490	COG4773	Receptor
KPZ59_RS09495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPZ59_RS09510	COG1131	(ABC) transporter
KPZ59_RS09515	COG0842	Transport permease protein
KPZ59_RS09520	COG0842	Transport permease protein
KPZ59_RS09575	COG2226	methyltransferase
KPZ59_RS09600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KPZ59_RS09635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KPZ59_RS09645	COG0133	tryptophan synthase activity
KPZ59_RS09660	COG3706	GGDEF domain
KPZ59_RS09675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KPZ59_RS09680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KPZ59_RS09685	COG0022	dehydrogenase e1 component
KPZ59_RS09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPZ59_RS09695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_RS09705	COG1063	alcohol dehydrogenase
KPZ59_RS09710	COG3781	membrane
KPZ59_RS09720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_RS09720	COG3453	Protein conserved in bacteria
KPZ59_RS09730	COG0730	response to heat
KPZ59_RS09745	COG2207	Transcriptional regulator
KPZ59_RS09745	COG3708	Transcriptional regulator
KPZ59_RS09750	COG1733	regulation of RNA biosynthetic process
KPZ59_RS09755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KPZ59_RS09765	COG2188	Transcriptional regulator
KPZ59_RS09785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_RS09805	COG0477	Major facilitator Superfamily
KPZ59_RS09815	COG1027	Aspartate ammonia-lyase
KPZ59_RS09830	COG0583	DNA-binding transcription factor activity
KPZ59_RS09835	COG0583	DNA-binding transcription factor activity
KPZ59_RS09840	COG0183	Belongs to the thiolase family
KPZ59_RS09845	COG2031	fatty acid transporter
KPZ59_RS09860	COG0583	DNA-binding transcription factor activity
KPZ59_RS09880	COG1309	transcriptional regulator
KPZ59_RS09890	COG2610	gluconate transmembrane transporter activity
KPZ59_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS09900	COG2207	Transcriptional regulator
KPZ59_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS09925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS09940	COG0543	2 iron, 2 sulfur cluster binding
KPZ59_RS09940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_RS09945	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KPZ59_RS09950	COG4638	Rieske (2fe-2S)
KPZ59_RS09960	COG0725	ABC transporter, periplasmic molybdate-binding protein
KPZ59_RS09965	COG4149	molybdate abc transporter
KPZ59_RS09970	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KPZ59_RS09975	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS09980	COG3433	isochorismatase activity
KPZ59_RS09980	COG1535	isochorismatase
KPZ59_RS10045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KPZ59_RS10060	COG0753	catalase activity
KPZ59_RS10070	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KPZ59_RS10100	COG3539	Fimbrial protein
KPZ59_RS10125	COG0747	negative chemotaxis
KPZ59_RS10130	COG0601	transmembrane transport
KPZ59_RS10135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KPZ59_RS10155	COG1132	(ABC) transporter
KPZ59_RS10160	COG1132	(ABC) transporter
KPZ59_RS10180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS10195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KPZ59_RS10215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KPZ59_RS10220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_RS10225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS10255	COG4771	TonB-dependent receptor
KPZ59_RS10260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS10270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KPZ59_RS10275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS10280	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS10285	COG2205	protein histidine kinase activity
KPZ59_RS10295	COG2207	Transcriptional regulator
KPZ59_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS10345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KPZ59_RS10395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KPZ59_RS10415	COG1120	ATPase activity
KPZ59_RS10420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KPZ59_RS10430	COG1064	alcohol dehydrogenase
KPZ59_RS10445	COG2207	Transcriptional regulator
KPZ59_RS10450	COG2084	Dehydrogenase
KPZ59_RS10460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KPZ59_RS10465	COG0583	DNA-binding transcription factor activity
KPZ59_RS10475	COG0129	dihydroxy-acid dehydratase activity
KPZ59_RS10480	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS10495	COG1566	PFAM secretion protein HlyD family protein
KPZ59_RS10505	COG2271	Major facilitator Superfamily
KPZ59_RS10520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS10545	COG0583	DNA-binding transcription factor activity
KPZ59_RS10560	COG2188	Transcriptional regulator
KPZ59_RS10600	COG3162	membrane
KPZ59_RS10610	COG3829	transcription factor binding
KPZ59_RS10615	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS10620	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS10635	COG3231	kanamycin kinase activity
KPZ59_RS10640	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS10660	COG2186	Transcriptional regulator
KPZ59_RS10670	COG0583	DNA-binding transcription factor activity
KPZ59_RS10675	COG4948	Mandelate Racemase Muconate Lactonizing
KPZ59_RS10680	COG4829	muconolactone delta-isomerase
KPZ59_RS10690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_RS10695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_RS10700	COG0183	Belongs to the thiolase family
KPZ59_RS10705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KPZ59_RS10710	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS10720	COG3733	amine oxidase
KPZ59_RS10730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS10740	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS10750	COG4638	Rieske (2fe-2S)
KPZ59_RS10770	COG0154	amidase activity
KPZ59_RS10780	COG2814	Major facilitator Superfamily
KPZ59_RS10805	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS10810	COG0583	DNA-binding transcription factor activity
KPZ59_RS10815	COG1414	Transcriptional regulator
KPZ59_RS10830	COG2391	methyltransferase activity
KPZ59_RS10840	COG4993	Dehydrogenase
KPZ59_RS10845	COG3659	wide pore channel activity
KPZ59_RS10850	COG3420	alginic acid biosynthetic process
KPZ59_RS10855	COG0710	3-dehydroquinate dehydratase activity
KPZ59_RS10860	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_RS10865	COG3485	protocatechuate 3,4-dioxygenase
KPZ59_RS10870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KPZ59_RS10875	COG2271	Major facilitator Superfamily
KPZ59_RS10880	COG0596	Alpha beta hydrolase
KPZ59_RS10885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KPZ59_RS10890	COG0183	Belongs to the thiolase family
KPZ59_RS10895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KPZ59_RS10900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KPZ59_RS10910	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KPZ59_RS10915	COG2323	membrane
KPZ59_RS10960	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_RS10960	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_RS10985	COG0542	response to heat
KPZ59_RS10990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KPZ59_RS11020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KPZ59_RS11025	COG0569	domain protein
KPZ59_RS11030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KPZ59_RS11045	COG4774	siderophore transport
KPZ59_RS11050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KPZ59_RS11060	COG1585	Membrane protein implicated in regulation of membrane protease activity
KPZ59_RS11075	COG1294	oxidase, subunit
KPZ59_RS11080	COG4890	Cyd operon protein YbgT
KPZ59_RS11090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
KPZ59_RS11100	COG0552	protein localization to endoplasmic reticulum
KPZ59_RS11125	COG0517	IMP dehydrogenase activity
KPZ59_RS11125	COG0516	GMP reductase activity
KPZ59_RS11130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPZ59_RS11135	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KPZ59_RS11145	COG0583	DNA-binding transcription factor activity
KPZ59_RS11150	COG0024	Methionine aminopeptidase
KPZ59_RS11180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KPZ59_RS11180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KPZ59_RS11185	COG1105	Belongs to the carbohydrate kinase PfkB family
KPZ59_RS11190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KPZ59_RS11190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KPZ59_RS11190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
KPZ59_RS11205	COG5001	Diguanylate cyclase
KPZ59_RS11205	COG3300	MHYT domain
KPZ59_RS11220	COG2135	peptidase activity
KPZ59_RS11225	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_RS11240	COG1113	amino acid transport
KPZ59_RS11250	COG1522	sequence-specific DNA binding
KPZ59_RS11275	COG1011	Hydrolase
KPZ59_RS11280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KPZ59_RS11290	COG2137	regulation of response to DNA damage stimulus
KPZ59_RS11305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KPZ59_RS11340	COG0575	Belongs to the CDS family
KPZ59_RS11345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KPZ59_RS11370	COG3852	Histidine kinase
KPZ59_RS11375	COG2204	response regulator
KPZ59_RS11430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KPZ59_RS11435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KPZ59_RS11455	COG0697	spore germination
KPZ59_RS11460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_RS11470	COG0303	'Molybdopterin
KPZ59_RS11475	COG0521	Mo-molybdopterin cofactor biosynthetic process
KPZ59_RS11475	COG0315	cyclic pyranopterin monophosphate synthase activity
KPZ59_RS11490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KPZ59_RS11495	COG0243	molybdopterin cofactor binding
KPZ59_RS11505	COG0243	molybdopterin cofactor binding
KPZ59_RS11510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_RS11515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_RS11515	COG2146	nitrite reductase [NAD(P)H] activity
KPZ59_RS11525	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS11530	COG1116	anion transmembrane transporter activity
KPZ59_RS11530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KPZ59_RS11550	COG0511	ligase activity, forming carbon-carbon bonds
KPZ59_RS11565	COG2814	Major facilitator Superfamily
KPZ59_RS11590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_RS11655	COG0592	DNA-directed DNA polymerase activity
KPZ59_RS11870	COG1484	DNA-dependent DNA replication
KPZ59_RS11960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KPZ59_RS12025	COG0069	glutamate synthase activity
KPZ59_RS12045	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KPZ59_RS12055	COG1454	alcohol dehydrogenase
KPZ59_RS12060	COG0824	Thioesterase
KPZ59_RS12070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KPZ59_RS12095	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KPZ59_RS12100	COG2030	dehydratase
KPZ59_RS12110	COG0183	Belongs to the thiolase family
KPZ59_RS12120	COG0583	DNA-binding transcription factor activity
KPZ59_RS12125	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KPZ59_RS12135	COG1522	sequence-specific DNA binding
KPZ59_RS12140	COG3135	benzoate transporter
KPZ59_RS12170	COG0589	response to stress
KPZ59_RS12185	COG4773	Receptor
KPZ59_RS12215	COG0668	transmembrane transport
KPZ59_RS12255	COG0583	DNA-binding transcription factor activity
KPZ59_RS12260	COG2814	Major facilitator Superfamily
KPZ59_RS12265	COG2814	Major facilitator Superfamily
KPZ59_RS12270	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS12275	COG0446	pyridine nucleotide-disulphide oxidoreductase
KPZ59_RS12280	COG3384	dioxygenase
KPZ59_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS12295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KPZ59_RS12300	COG4638	Rieske (2fe-2S)
KPZ59_RS12305	COG0583	DNA-binding transcription factor activity
KPZ59_RS12325	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KPZ59_RS12330	COG3971	2-oxopent-4-enoate hydratase activity
KPZ59_RS12340	COG2271	Major facilitator Superfamily
KPZ59_RS12345	COG1234	tRNA 3'-trailer cleavage
KPZ59_RS12380	COG1538	Outer membrane efflux protein
KPZ59_RS12410	COG2885	chlorophyll binding
KPZ59_RS12410	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KPZ59_RS12455	COG1605	Chorismate mutase
KPZ59_RS12475	COG0308	aminopeptidase N
KPZ59_RS12495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KPZ59_RS12505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KPZ59_RS12510	COG1454	alcohol dehydrogenase
KPZ59_RS12530	COG0531	amino acid
KPZ59_RS12535	COG4303	Ethanolamine ammonia lyase large subunit
KPZ59_RS12540	COG4302	ethanolamine ammonia-lyase activity
KPZ59_RS12545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KPZ59_RS12545	COG0519	Catalyzes the synthesis of GMP from XMP
KPZ59_RS12550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KPZ59_RS12575	COG0697	spore germination
KPZ59_RS12580	COG1923	regulation of RNA biosynthetic process
KPZ59_RS12590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KPZ59_RS12595	COG0802	atpase or kinase
KPZ59_RS12615	COG1187	pseudouridine synthase activity
KPZ59_RS12630	COG0583	DNA-binding transcription factor activity
KPZ59_RS12645	COG2814	Major facilitator Superfamily
KPZ59_RS12650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KPZ59_RS12675	COG0729	surface antigen
KPZ59_RS12695	COG0174	glutamine synthetase
KPZ59_RS12700	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS12705	COG2205	protein histidine kinase activity
KPZ59_RS12715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KPZ59_RS12720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KPZ59_RS12745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS12750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_RS12755	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS12785	COG0583	DNA-binding transcription factor activity
KPZ59_RS12800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KPZ59_RS12810	COG3658	cytochrome
KPZ59_RS12815	COG1215	transferase activity, transferring glycosyl groups
KPZ59_RS12820	COG0726	polysaccharide deacetylase
KPZ59_RS12820	COG1649	PFAM Uncharacterised BCR, COG1649
KPZ59_RS12845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KPZ59_RS12850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KPZ59_RS12860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KPZ59_RS12885	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_RS12890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KPZ59_RS12900	COG1305	Transglutaminase-like
KPZ59_RS12910	COG2308	Evidence 4 Homologs of previously reported genes of
KPZ59_RS12940	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KPZ59_RS12945	COG0138	bifunctional purine biosynthesis protein purh
KPZ59_RS12950	COG0151	Belongs to the GarS family
KPZ59_RS12955	COG1464	Belongs to the NlpA lipoprotein family
KPZ59_RS12960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KPZ59_RS12965	COG2011	ABC-type metal ion transport system permease component
KPZ59_RS12970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KPZ59_RS12980	COG1301	dicarboxylic acid transport
KPZ59_RS13005	COG2814	Major facilitator Superfamily
KPZ59_RS13020	COG1309	transcriptional regulator
KPZ59_RS13040	COG1794	racemase activity, acting on amino acids and derivatives
KPZ59_RS13045	COG0492	ferredoxin-NADP+ reductase activity
KPZ59_RS13045	COG3118	belongs to the thioredoxin family
KPZ59_RS13060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
KPZ59_RS13060	COG3008	intermembrane lipid transfer
KPZ59_RS13065	COG2995	paraquat-inducible protein a
KPZ59_RS13095	COG1051	belongs to the nudix hydrolase family
KPZ59_RS13100	COG0477	Major facilitator Superfamily
KPZ59_RS13150	COG2186	Transcriptional regulator
KPZ59_RS13160	COG0786	glutamate:sodium symporter activity
KPZ59_RS13165	COG3243	poly(R)-hydroxyalkanoic acid synthase
KPZ59_RS13195	COG3111	PFAM Bacterial OB fold (BOF) protein
KPZ59_RS13205	COG2226	methyltransferase
KPZ59_RS13280	COG3210	domain, Protein
KPZ59_RS13280	COG3210	domain, Protein
KPZ59_RS13285	COG2831	hemolysin activation secretion protein
KPZ59_RS13310	COG2815	serine threonine protein kinase
KPZ59_RS13310	COG0515	serine threonine protein kinase
KPZ59_RS13340	COG1610	YqeY-like protein
KPZ59_RS13345	COG4783	chaperone-mediated protein folding
KPZ59_RS13370	COG1286	toxin biosynthetic process
KPZ59_RS13400	COG0778	Nitroreductase
KPZ59_RS13410	COG0513	Belongs to the DEAD box helicase family
KPZ59_RS13430	COG2363	Small membrane protein
KPZ59_RS13460	COG4650	regulator
KPZ59_RS13465	COG1234	tRNA 3'-trailer cleavage
KPZ59_RS13470	COG1690	Belongs to the RtcB family
KPZ59_RS13490	COG2195	Cleaves the N-terminal amino acid of tripeptides
KPZ59_RS13500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KPZ59_RS13510	COG2819	hydrolase of the alpha beta superfamily
KPZ59_RS13515	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS13520	COG1301	dicarboxylic acid transport
KPZ59_RS13525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KPZ59_RS13530	COG3139	Protein of unknown function (DUF1315)
KPZ59_RS13535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KPZ59_RS13540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KPZ59_RS13550	COG0494	nUDIX hydrolase
KPZ59_RS13560	COG0642	Histidine kinase
KPZ59_RS13575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KPZ59_RS13585	COG1720	tRNA m6t6A37 methyltransferase activity
KPZ59_RS13600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_RS13605	COG0826	peptidase U32
KPZ59_RS13610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KPZ59_RS13620	COG4598	ABC transporter
KPZ59_RS13625	COG4160	amino acid transport
KPZ59_RS13630	COG4215	(ABC) transporter
KPZ59_RS13645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS13690	COG1131	(ABC) transporter
KPZ59_RS13695	COG0842	Transport permease protein
KPZ59_RS13710	COG0772	Belongs to the SEDS family
KPZ59_RS13715	COG2951	lytic endotransglycosylase activity
KPZ59_RS13740	COG2207	Transcriptional regulator
KPZ59_RS13755	COG0052	Belongs to the universal ribosomal protein uS2 family
KPZ59_RS13760	COG0024	Methionine aminopeptidase
KPZ59_RS13770	COG2223	nitrite transmembrane transporter activity
KPZ59_RS13780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_RS13785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KPZ59_RS13790	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS13805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KPZ59_RS13810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KPZ59_RS13815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KPZ59_RS13835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPZ59_RS13840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KPZ59_RS13845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KPZ59_RS13880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KPZ59_RS13890	COG0174	glutamine synthetase
KPZ59_RS13905	COG0512	Glutamine amidotransferase of anthranilate synthase
KPZ59_RS13910	COG0308	aminopeptidase N
KPZ59_RS13930	COG2840	Smr protein MutS2
KPZ59_RS13940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
KPZ59_RS13950	COG0302	gtp cyclohydrolase
KPZ59_RS13975	COG3739	integral membrane protein
KPZ59_RS13990	COG1169	isochorismate synthase
KPZ59_RS14000	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KPZ59_RS14005	COG1132	(ABC) transporter
KPZ59_RS14010	COG1132	(ABC) transporter
KPZ59_RS14025	COG1535	isochorismatase
KPZ59_RS14025	COG3433	isochorismatase activity
KPZ59_RS14030	COG1021	2,3-dihydroxybenzoate-AMP ligase
KPZ59_RS14035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_RS14045	COG4774	siderophore transport
KPZ59_RS14050	COG4607	ABC-type enterochelin transport system periplasmic component
KPZ59_RS14055	COG4604	ABC transporter, ATP-binding protein
KPZ59_RS14060	COG4605	iron ion homeostasis
KPZ59_RS14065	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KPZ59_RS14070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_RS14085	COG2964	Protein conserved in bacteria
KPZ59_RS14095	COG1741	Belongs to the pirin family
KPZ59_RS14135	COG2879	small protein
KPZ59_RS14140	COG1966	Carbon starvation protein
KPZ59_RS14160	COG4943	cyclic-guanylate-specific phosphodiesterase activity
KPZ59_RS14180	COG2211	Major facilitator Superfamily
KPZ59_RS14185	COG1067	ATP-dependent peptidase activity
KPZ59_RS14190	COG0583	DNA-binding transcription factor activity
KPZ59_RS14215	COG1686	Belongs to the peptidase S11 family
KPZ59_RS14220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KPZ59_RS14255	COG0616	signal peptide processing
KPZ59_RS14260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KPZ59_RS14270	COG0573	inorganic phosphate transmembrane transporter activity
KPZ59_RS14275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KPZ59_RS14280	COG1113	amino acid transport
KPZ59_RS14285	COG3961	Belongs to the TPP enzyme family
KPZ59_RS14290	COG1522	sequence-specific DNA binding
KPZ59_RS14300	COG0076	glutamate decarboxylase activity
KPZ59_RS14305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KPZ59_RS14315	COG1309	transcriptional regulator
KPZ59_RS14330	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_RS14365	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_RS14390	COG1203	CRISPR-associated helicase, Cas3
KPZ59_RS14420	COG0612	Peptidase, M16
KPZ59_RS14430	COG1823	symporter activity
KPZ59_RS14435	COG0583	DNA-binding transcription factor activity
KPZ59_RS14440	COG0477	Major facilitator Superfamily
KPZ59_RS14465	COG1187	pseudouridine synthase activity
KPZ59_RS14480	COG1686	Belongs to the peptidase S11 family
KPZ59_RS14485	COG1252	NADH dehydrogenase
KPZ59_RS14495	COG0415	Belongs to the DNA photolyase family
KPZ59_RS14510	COG1215	transferase activity, transferring glycosyl groups
KPZ59_RS14540	COG2070	2-Nitropropane dioxygenase
KPZ59_RS14595	COG0556	nucleotide-excision repair
KPZ59_RS14615	COG0436	Aminotransferase
KPZ59_RS14645	COG4221	oxidoreductase activity
KPZ59_RS14655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KPZ59_RS14660	COG1381	Involved in DNA repair and RecF pathway recombination
KPZ59_RS14670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KPZ59_RS14685	COG0681	Belongs to the peptidase S26 family
KPZ59_RS14700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KPZ59_RS14720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KPZ59_RS14725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KPZ59_RS14730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KPZ59_RS14740	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
KPZ59_RS14745	COG4208	sulfate ABC transporter
KPZ59_RS14750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KPZ59_RS14755	COG0583	DNA-binding transcription factor activity
KPZ59_RS14760	COG4625	pathogenesis
KPZ59_RS14775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KPZ59_RS14790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KPZ59_RS14800	COG1056	cytidyltransferase-related domain
KPZ59_RS14800	COG1051	belongs to the nudix hydrolase family
KPZ59_RS14805	COG1024	Enoyl-CoA hydratase
KPZ59_RS14815	COG2814	Major facilitator Superfamily
KPZ59_RS14820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KPZ59_RS14820	COG0047	phosphoribosylformylglycinamidine synthase activity
KPZ59_RS14840	COG1473	amidohydrolase
KPZ59_RS14845	COG0824	Thioesterase
KPZ59_RS14865	COG0823	Involved in the tonB-independent uptake of proteins
KPZ59_RS14885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KPZ59_RS14920	COG0628	permease
KPZ59_RS14930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KPZ59_RS14935	COG0596	Alpha beta hydrolase
KPZ59_RS14940	COG0616	signal peptide processing
KPZ59_RS14940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
KPZ59_RS14950	COG0658	competence protein
KPZ59_RS14950	COG2333	competence protein COMEC
KPZ59_RS14955	COG1136	(ABC) transporter
KPZ59_RS14960	COG4591	ABC-type transport system involved in lipoprotein release permease component
KPZ59_RS14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS15015	COG0463	Glycosyl transferase, family 2
KPZ59_RS15045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KPZ59_RS15050	COG1280	lysine exporter protein (LysE YggA)
KPZ59_RS15060	COG0019	diaminopimelate decarboxylase activity
KPZ59_RS15070	COG1113	amino acid transport
KPZ59_RS15085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KPZ59_RS15095	COG3339	Conserved Protein
KPZ59_RS15100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KPZ59_RS15105	COG0243	molybdopterin cofactor binding
KPZ59_RS15110	COG1929	Belongs to the glycerate kinase type-1 family
KPZ59_RS15130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KPZ59_RS15150	COG0741	lytic transglycosylase activity
KPZ59_RS15170	COG0584	glycerophosphoryl diester phosphodiesterase
KPZ59_RS15195	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KPZ59_RS15200	COG1597	lipid kinase activity
KPZ59_RS15215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KPZ59_RS15220	COG0477	Major facilitator Superfamily
KPZ59_RS15270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KPZ59_RS15275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KPZ59_RS15300	COG0505	Belongs to the CarA family
KPZ59_RS15320	COG0589	response to stress
KPZ59_RS15335	COG2843	Capsule synthesis protein
KPZ59_RS15355	COG2321	neutral zinc metallopeptidase
KPZ59_RS15360	COG2354	Protein conserved in bacteria
KPZ59_RS15380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KPZ59_RS15405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KPZ59_RS15410	COG1053	succinate dehydrogenase
KPZ59_RS15415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KPZ59_RS15420	COG2009	succinate dehydrogenase
KPZ59_RS15455	COG2921	Belongs to the UPF0250 family
KPZ59_RS15460	COG0321	lipoyl(octanoyl) transferase activity
KPZ59_RS15475	COG0531	amino acid
KPZ59_RS15485	COG1733	regulation of RNA biosynthetic process
KPZ59_RS15490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KPZ59_RS15495	COG1648	precorrin-2 dehydrogenase activity
KPZ59_RS15495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KPZ59_RS15510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KPZ59_RS15540	COG0671	phosphoesterase, PA-phosphatase related
KPZ59_RS15545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS15555	COG1538	Outer membrane efflux protein
KPZ59_RS15560	COG0393	Putative heavy-metal-binding
KPZ59_RS15565	COG0393	Putative heavy-metal-binding
KPZ59_RS15575	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS15585	COG0525	valine-tRNA ligase activity
KPZ59_RS15605	COG0583	DNA-binding transcription factor activity
KPZ59_RS15610	COG0004	ammonium transporteR
KPZ59_RS15620	COG0642	Histidine kinase
KPZ59_RS15625	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS15630	COG2194	sulfuric ester hydrolase activity
KPZ59_RS15650	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPZ59_RS15665	COG2315	Protein conserved in bacteria
KPZ59_RS15670	COG0142	geranyltranstransferase activity
KPZ59_RS15675	COG2828	Protein conserved in bacteria
KPZ59_RS15680	COG1113	amino acid transport
KPZ59_RS15690	COG0582	viral genome integration into host DNA
KPZ59_RS15725	COG0305	Participates in initiation and elongation during chromosome replication
KPZ59_RS15775	COG0464	growth
KPZ59_RS15795	COG2207	Transcriptional regulator
KPZ59_RS15820	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_RS15830	COG0560	Phosphoserine phosphatase
KPZ59_RS15840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KPZ59_RS15850	COG1530	ribonuclease E activity
KPZ59_RS15855	COG0424	maF-like protein
KPZ59_RS15860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KPZ59_RS15865	COG1792	Involved in formation and maintenance of cell shape
KPZ59_RS15870	COG1077	Cell shape determining protein MreB Mrl
KPZ59_RS15875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KPZ59_RS15885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KPZ59_RS15910	COG3590	peptidase
KPZ59_RS15915	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KPZ59_RS15920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KPZ59_RS15925	COG1752	Esterase of the alpha-beta hydrolase superfamily
KPZ59_RS15930	COG1115	amino acid carrier protein
KPZ59_RS15950	COG2814	Major facilitator Superfamily
KPZ59_RS15955	COG1289	transmembrane transporter activity
KPZ59_RS15965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KPZ59_RS16005	COG1376	ErfK ybiS ycfS ynhG family protein
KPZ59_RS16010	COG2832	Protein of unknown function (DUF454)
KPZ59_RS16020	COG5510	response to toxic substance
KPZ59_RS16040	COG0840	transmembrane signaling receptor activity
KPZ59_RS16080	COG3422	double-strand break repair
KPZ59_RS16085	COG2824	Alkylphosphonate utilization operon protein PhnA
KPZ59_RS16090	COG3189	MarR family transcriptional regulator
KPZ59_RS16100	COG0354	folic acid binding
KPZ59_RS16105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_RS16115	COG0679	Auxin Efflux Carrier
KPZ59_RS16120	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_RS16125	COG4772	TonB-dependent receptor
KPZ59_RS16130	COG2094	Belongs to the DNA glycosylase MPG family
KPZ59_RS16155	COG1217	gtp-binding protein TYPA
KPZ59_RS16160	COG2233	PERMEase
KPZ59_RS16170	COG0833	amino acid
KPZ59_RS16175	COG1690	Belongs to the RtcB family
KPZ59_RS16185	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
KPZ59_RS16185	COG2885	chlorophyll binding
KPZ59_RS16195	COG0183	Belongs to the thiolase family
KPZ59_RS16215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KPZ59_RS16235	COG2207	Transcriptional regulator
KPZ59_RS16240	COG0183	Belongs to the thiolase family
KPZ59_RS16260	COG2153	protein acetylation
KPZ59_RS16270	COG1272	protein, Hemolysin III
KPZ59_RS16275	COG0477	Major facilitator Superfamily
KPZ59_RS16290	COG0450	alkyl hydroperoxide reductase
KPZ59_RS16310	COG0285	dihydrofolate synthase activity
KPZ59_RS16360	COG2096	Adenosyltransferase
KPZ59_RS16380	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KPZ59_RS16385	COG0745	RESPONSE REGULATOR receiver
KPZ59_RS16390	COG2205	protein histidine kinase activity
KPZ59_RS16400	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS16405	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS16455	COG1215	transferase activity, transferring glycosyl groups
KPZ59_RS16470	COG1091	dTDP-4-dehydrorhamnose reductase activity
KPZ59_RS16490	COG0726	polysaccharide deacetylase
KPZ59_RS16505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KPZ59_RS16510	COG5002	protein histidine kinase activity
KPZ59_RS16540	COG1862	Preprotein translocase
KPZ59_RS16550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KPZ59_RS16555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KPZ59_RS16565	COG3781	membrane
KPZ59_RS16570	COG0613	PHP domain protein
KPZ59_RS16580	COG2350	Protein conserved in bacteria
KPZ59_RS16610	COG1607	acyl-coa hydrolase
KPZ59_RS16670	COG2199	diguanylate cyclase activity
KPZ59_RS16680	COG1408	metallophosphoesterase
KPZ59_RS16685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KPZ59_RS16695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KPZ59_RS16715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KPZ59_RS16720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KPZ59_RS16725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KPZ59_RS16735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KPZ59_RS16745	COG2969	positive regulation of protein catabolic process
KPZ59_RS16765	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS16770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KPZ59_RS16785	COG1309	transcriptional regulator
KPZ59_RS16790	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS16835	COG1183	phosphatidylcholine synthase activity
KPZ59_RS16840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KPZ59_RS16870	COG0741	lytic transglycosylase activity
KPZ59_RS16870	COG1196	nuclear chromosome segregation
KPZ59_RS16870	COG0739	heme binding
KPZ59_RS16880	COG1702	phosphate starvation-inducible protein PhoH
KPZ59_RS16915	COG1295	ribonuclease BN
KPZ59_RS16920	COG0697	spore germination
KPZ59_RS16925	COG2169	Transcriptional regulator
KPZ59_RS16930	COG0179	Fumarylacetoacetate (FAA) hydrolase
KPZ59_RS16975	COG0557	exoribonuclease II activity
KPZ59_RS16980	COG0339	signal peptide processing
KPZ59_RS16985	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KPZ59_RS17015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KPZ59_RS17020	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS17175	COG0626	cystathionine gamma-synthase activity
KPZ59_RS17180	COG0433	COG0433 Predicted ATPase
KPZ59_RS17190	COG1017	nitric oxide dioxygenase activity
KPZ59_RS17190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KPZ59_RS17195	COG1959	2 iron, 2 sulfur cluster binding
KPZ59_RS17210	COG1301	dicarboxylic acid transport
KPZ59_RS17215	COG1946	Acyl-CoA thioesterase
KPZ59_RS17235	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KPZ59_RS17240	COG1040	competence protein
KPZ59_RS17245	COG0494	nUDIX hydrolase
KPZ59_RS17255	COG0598	Magnesium transport protein CorA
KPZ59_RS17265	COG2854	intermembrane phospholipid transfer
KPZ59_RS17275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KPZ59_RS17280	COG1127	ABC transporter
KPZ59_RS17290	COG0513	Belongs to the DEAD box helicase family
KPZ59_RS17310	COG0408	coproporphyrinogen oxidase activity
KPZ59_RS17325	COG1960	acyl-CoA dehydrogenase activity
KPZ59_RS17335	COG1983	PspC domain protein
KPZ59_RS17340	COG0517	IMP dehydrogenase activity
KPZ59_RS17360	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS17385	COG0833	amino acid
KPZ59_RS17390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KPZ59_RS17395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KPZ59_RS17405	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS17445	COG0583	DNA-binding transcription factor activity
KPZ59_RS17465	COG1106	Psort location Cytoplasmic, score
KPZ59_RS17480	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS17490	COG1192	Involved in chromosome partitioning
KPZ59_RS17495	COG0628	permease
KPZ59_RS17510	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS17530	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_RS17535	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KPZ59_RS17545	COG0277	FAD linked oxidase domain protein
KPZ59_RS17550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KPZ59_RS17575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KPZ59_RS17580	COG5380	lipid catabolic process
KPZ59_RS17600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KPZ59_RS17650	COG0194	GDP metabolic process
KPZ59_RS17665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KPZ59_RS17685	COG3307	-O-antigen
KPZ59_RS17700	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KPZ59_RS17705	COG1704	LemA family
KPZ59_RS17715	COG0493	'glutamate synthase
KPZ59_RS17720	COG0067	glutamate synthase
KPZ59_RS17720	COG0069	glutamate synthase activity
KPZ59_RS17720	COG0070	glutamate synthase
KPZ59_RS17770	COG2226	methyltransferase
KPZ59_RS17785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KPZ59_RS17790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KPZ59_RS17835	COG0833	amino acid
KPZ59_RS17900	COG0488	(ABC) transporter
KPZ59_RS17905	COG2873	o-acetylhomoserine
KPZ59_RS17910	COG4221	oxidoreductase activity
KPZ59_RS17915	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_RS17940	COG0427	acetyl-CoA hydrolase
KPZ59_RS17970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KPZ59_RS18005	COG2329	Antibiotic biosynthesis monooxygenase
KPZ59_RS18020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KPZ59_RS18100	COG2249	NAD(P)H dehydrogenase (quinone) activity
KPZ59_RS18105	COG1733	regulation of RNA biosynthetic process
KPZ59_RS18135	COG1733	regulation of RNA biosynthetic process
KPZ59_RS18155	COG0667	Aldo Keto reductase
KPZ59_RS18175	COG0583	DNA-binding transcription factor activity
KPZ59_RS18180	COG2814	Major facilitator Superfamily
KPZ59_RS18210	COG1335	isochorismatase
KPZ59_RS18220	COG1012	belongs to the aldehyde dehydrogenase family
KPZ59_RS18225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KPZ59_RS18235	COG1113	amino acid transport
KPZ59_RS18245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KPZ59_RS18285	COG2814	Major facilitator Superfamily
KPZ59_RS18295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KPZ59_RS18295	COG0352	thiamine-phosphate diphosphorylase activity
KPZ59_RS18295	COG0351	phosphomethylpyrimidine kinase
KPZ59_RS18315	COG1309	transcriptional regulator
KPZ59_RS18320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KPZ59_RS18335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KPZ59_RS18345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KPZ59_RS18350	COG3162	membrane
KPZ59_RS18355	COG2205	protein histidine kinase activity
KPZ59_RS18355	COG2198	Histidine kinase
KPZ59_RS18355	COG0784	Response regulator, receiver
KPZ59_RS18380	COG1522	sequence-specific DNA binding
KPZ59_RS18385	COG1335	isochorismatase
KPZ59_RS18390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KPZ59_RS18400	COG0668	transmembrane transport
KPZ59_RS18405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KPZ59_RS18410	COG1519	Transferase
KPZ59_RS18415	COG1902	pentaerythritol trinitrate reductase activity
KPZ59_RS18440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KPZ59_RS18465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KPZ59_RS18465	COG0426	domain, Protein
KPZ59_RS18470	COG4774	siderophore transport
KPZ59_RS18475	COG2119	membrane
KPZ59_RS18485	COG0508	dehydrogenase complex catalyzes the overall conversion of
KPZ59_RS18495	COG4942	peptidase
KPZ59_RS18510	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KPZ59_RS18520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KPZ59_RS18540	COG0189	ligase activity
KPZ59_RS18565	COG0708	Exodeoxyribonuclease III
KPZ59_RS18570	COG1393	Belongs to the ArsC family
KPZ59_RS18585	COG3706	GGDEF domain
KPZ59_RS18620	COG2351	hydroxyisourate hydrolase activity
KPZ59_RS18625	COG2233	PERMEase
KPZ59_RS18635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KPZ59_RS18645	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
KPZ59_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
KPZ59_RS18660	COG3150	esterase
KPZ59_RS18705	COG1388	LysM domain
KPZ59_RS18705	COG5632	N-Acetylmuramoyl-L-alanine amidase
KPZ59_RS18705	COG3409	Peptidoglycan-binding domain 1 protein
KPZ59_RS18720	COG2918	glutathione biosynthetic process
KPZ59_RS18735	COG2733	membrane
KPZ59_RS18740	COG0436	Aminotransferase
KPZ59_RS18745	COG0534	Mate efflux family protein
KPZ59_RS18830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KPZ59_RS18835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KPZ59_RS18845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KPZ59_RS18850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KPZ59_RS18855	COG0546	phosphoglycolate phosphatase activity
KPZ59_RS18865	COG0010	Belongs to the arginase family
KPZ59_RS18895	COG2188	Transcriptional regulator
KPZ59_RS18905	COG0523	cobalamin synthesis protein
KPZ59_RS18915	COG1113	amino acid transport
KPZ59_RS18925	COG0625	glutathione transferase activity
KPZ59_RS18945	COG1683	Conserved Protein
KPZ59_RS18950	COG0534	Mate efflux family protein
KPZ59_RS18955	COG0385	Bile acid
KPZ59_RS18960	COG1335	isochorismatase
KPZ59_RS18965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KPZ59_RS18985	COG2116	formate transmembrane transporter activity
KPZ59_RS18990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KPZ59_RS18995	COG2133	pyrroloquinoline quinone binding
KPZ59_RS19000	COG2983	Belongs to the UPF0260 family
KPZ59_RS19020	COG1194	a g-specific adenine glycosylase
KPZ59_RS19035	COG2818	Glycosylase
KPZ59_RS19040	COG1064	alcohol dehydrogenase
KPZ59_RS19045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KPZ59_RS19060	COG0583	DNA-binding transcription factor activity
KPZ59_RS19065	COG0656	L-ascorbic acid biosynthetic process
KPZ59_RS19070	COG2814	Major facilitator Superfamily
KPZ59_RS19105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KPZ59_RS19120	COG2233	PERMEase
KPZ59_RS19125	COG0583	DNA-binding transcription factor activity
KPZ59_RS19160	COG0733	neurotransmitter:sodium symporter activity
KPZ59_RS19330	COG1525	nuclease
KPZ59_RS19390	COG1475	DNA binding
KPZ59_RS19405	COG3853	Toxic anion resistance protein (TelA)
KPZ59_RS19445	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS19455	COG2826	transposase and inactivated derivatives, IS30 family
KPZ59_RS19505	COG1002	Type II restriction enzyme, methylase subunits
KPZ59_RS19540	COG0484	heat shock protein binding
KPZ59_RS19625	COG0741	lytic transglycosylase activity
KPZ59_RS19660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KPZ59_RS19740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_RS19760	COG1192	Involved in chromosome partitioning
KPZ59_RS19770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KPZ59_RS19810	COG0739	heme binding
KPZ59_RS20050	COG0501	Belongs to the peptidase M48B family
KPZ59_RS20160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KPZ59_RS20200	COG3173	Aminoglycoside phosphotransferase
KPZ59_RS20205	COG0488	(ABC) transporter
KPZ59_RS20215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KPZ59_RS20255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KPZ59_RS20405	COG2233	PERMEase
KPZ59_RS20410	COG2351	hydroxyisourate hydrolase activity
KPZ59_RS20465	COG0789	Transcriptional regulator
KPZ59_RS20485	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KPZ59_RS20495	COG0659	secondary active sulfate transmembrane transporter activity
KPZ59_RS20550	COG1373	ATPase (AAA superfamily
KPZ59_RS20590	COG1309	transcriptional regulator
KPZ59_RS20615	COG0633	Ferredoxin
KPZ59_RS20620	COG2207	Transcriptional regulator
KPZ59_RS20775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB