locus-tag	class	description
DLD53_RS00175	COG0582	viral genome integration into host DNA
DLD53_RS00190	COG0174	glutamine synthetase
DLD53_RS00200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DLD53_RS00235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DLD53_RS00240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DLD53_RS00245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLD53_RS00275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLD53_RS00280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DLD53_RS00285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DLD53_RS00300	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS00305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLD53_RS00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLD53_RS00320	COG2223	nitrite transmembrane transporter activity
DLD53_RS00330	COG0024	Methionine aminopeptidase
DLD53_RS00335	COG0052	Belongs to the universal ribosomal protein uS2 family
DLD53_RS00350	COG2207	Transcriptional regulator
DLD53_RS00375	COG2951	lytic endotransglycosylase activity
DLD53_RS00380	COG0772	Belongs to the SEDS family
DLD53_RS00395	COG0842	Transport permease protein
DLD53_RS00400	COG1131	(ABC) transporter
DLD53_RS00445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS00460	COG4215	(ABC) transporter
DLD53_RS00465	COG4160	amino acid transport
DLD53_RS00470	COG4598	ABC transporter
DLD53_RS00480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DLD53_RS00485	COG0826	peptidase U32
DLD53_RS00490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLD53_RS00505	COG1720	tRNA m6t6A37 methyltransferase activity
DLD53_RS00515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DLD53_RS00530	COG0642	Histidine kinase
DLD53_RS00540	COG0494	nUDIX hydrolase
DLD53_RS00550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLD53_RS00555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DLD53_RS00560	COG3139	Protein of unknown function (DUF1315)
DLD53_RS00565	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DLD53_RS00575	COG1301	dicarboxylic acid transport
DLD53_RS00580	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS00585	COG2819	hydrolase of the alpha beta superfamily
DLD53_RS00595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DLD53_RS00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
DLD53_RS00610	COG1234	tRNA 3'-trailer cleavage
DLD53_RS00640	COG2363	Small membrane protein
DLD53_RS00660	COG0513	Belongs to the DEAD box helicase family
DLD53_RS00670	COG0778	Nitroreductase
DLD53_RS00700	COG1286	toxin biosynthetic process
DLD53_RS00725	COG4783	chaperone-mediated protein folding
DLD53_RS00730	COG1610	YqeY-like protein
DLD53_RS00830	COG3111	PFAM Bacterial OB fold (BOF) protein
DLD53_RS00865	COG3243	poly(R)-hydroxyalkanoic acid synthase
DLD53_RS00870	COG0786	glutamate:sodium symporter activity
DLD53_RS00880	COG2186	Transcriptional regulator
DLD53_RS00930	COG0477	Major facilitator Superfamily
DLD53_RS00960	COG2985	domain, Protein
DLD53_RS00970	COG2995	paraquat-inducible protein a
DLD53_RS00975	COG3008	intermembrane lipid transfer
DLD53_RS00975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DLD53_RS00985	COG1794	racemase activity, acting on amino acids and derivatives
DLD53_RS01015	COG1301	dicarboxylic acid transport
DLD53_RS01030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLD53_RS01035	COG2011	ABC-type metal ion transport system permease component
DLD53_RS01040	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLD53_RS01045	COG1464	Belongs to the NlpA lipoprotein family
DLD53_RS01050	COG0151	Belongs to the GarS family
DLD53_RS01055	COG0138	bifunctional purine biosynthesis protein purh
DLD53_RS01060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DLD53_RS01090	COG2308	Evidence 4 Homologs of previously reported genes of
DLD53_RS01100	COG1305	Transglutaminase-like
DLD53_RS01110	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DLD53_RS01115	COG0305	Participates in initiation and elongation during chromosome replication
DLD53_RS01140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DLD53_RS01150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLD53_RS01155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DLD53_RS01180	COG0726	polysaccharide deacetylase
DLD53_RS01180	COG1649	PFAM Uncharacterised BCR, COG1649
DLD53_RS01195	COG1215	transferase activity, transferring glycosyl groups
DLD53_RS01200	COG3658	cytochrome
DLD53_RS01210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLD53_RS01230	COG0583	DNA-binding transcription factor activity
DLD53_RS01250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLD53_RS01255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLD53_RS01270	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS01275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLD53_RS01280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLD53_RS01305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DLD53_RS01310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DLD53_RS01320	COG2205	protein histidine kinase activity
DLD53_RS01325	COG0745	RESPONSE REGULATOR receiver
DLD53_RS01330	COG0174	glutamine synthetase
DLD53_RS01350	COG0729	surface antigen
DLD53_RS01380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLD53_RS01385	COG2814	Major facilitator Superfamily
DLD53_RS01400	COG0583	DNA-binding transcription factor activity
DLD53_RS01415	COG1187	pseudouridine synthase activity
DLD53_RS01435	COG0802	atpase or kinase
DLD53_RS01440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DLD53_RS01450	COG1923	regulation of RNA biosynthetic process
DLD53_RS01455	COG0697	spore germination
DLD53_RS01470	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLD53_RS01480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLD53_RS01485	COG0519	Catalyzes the synthesis of GMP from XMP
DLD53_RS01485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLD53_RS01490	COG4302	ethanolamine ammonia-lyase activity
DLD53_RS01495	COG4303	Ethanolamine ammonia lyase large subunit
DLD53_RS01500	COG0531	amino acid
DLD53_RS01520	COG1454	alcohol dehydrogenase
DLD53_RS01525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DLD53_RS01535	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DLD53_RS01555	COG0308	aminopeptidase N
DLD53_RS01565	COG4221	oxidoreductase activity
DLD53_RS01575	COG1605	Chorismate mutase
DLD53_RS01595	COG1309	transcriptional regulator
DLD53_RS01605	COG0668	transmembrane transport
DLD53_RS01635	COG4773	Receptor
DLD53_RS01655	COG0488	(ABC) transporter
DLD53_RS01660	COG0589	response to stress
DLD53_RS01675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DLD53_RS01685	COG3135	benzoate transporter
DLD53_RS01690	COG1522	sequence-specific DNA binding
DLD53_RS01700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLD53_RS01705	COG0583	DNA-binding transcription factor activity
DLD53_RS01715	COG0183	Belongs to the thiolase family
DLD53_RS01725	COG2030	dehydratase
DLD53_RS01730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLD53_RS01745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DLD53_RS01755	COG0824	Thioesterase
DLD53_RS01760	COG1454	alcohol dehydrogenase
DLD53_RS01770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLD53_RS01790	COG0069	glutamate synthase activity
DLD53_RS02150	COG2194	sulfuric ester hydrolase activity
DLD53_RS02155	COG2814	Major facilitator Superfamily
DLD53_RS02170	COG0511	ligase activity, forming carbon-carbon bonds
DLD53_RS02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLD53_RS02190	COG1116	anion transmembrane transporter activity
DLD53_RS02195	COG0745	RESPONSE REGULATOR receiver
DLD53_RS02205	COG2146	nitrite reductase [NAD(P)H] activity
DLD53_RS02205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLD53_RS02210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLD53_RS02215	COG0243	molybdopterin cofactor binding
DLD53_RS02225	COG0243	molybdopterin cofactor binding
DLD53_RS02230	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DLD53_RS02245	COG0521	Mo-molybdopterin cofactor biosynthetic process
DLD53_RS02245	COG0315	cyclic pyranopterin monophosphate synthase activity
DLD53_RS02250	COG0303	'Molybdopterin
DLD53_RS02260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLD53_RS02265	COG0697	spore germination
DLD53_RS02285	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DLD53_RS02290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DLD53_RS02355	COG2204	response regulator
DLD53_RS02360	COG3852	Histidine kinase
DLD53_RS02380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLD53_RS02385	COG0575	Belongs to the CDS family
DLD53_RS02420	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLD53_RS02435	COG2137	regulation of response to DNA damage stimulus
DLD53_RS02445	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DLD53_RS02450	COG1011	Hydrolase
DLD53_RS02475	COG1522	sequence-specific DNA binding
DLD53_RS02485	COG1113	amino acid transport
DLD53_RS02495	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS02505	COG0659	secondary active sulfate transmembrane transporter activity
DLD53_RS02510	COG2135	peptidase activity
DLD53_RS02525	COG3300	MHYT domain
DLD53_RS02525	COG5001	Diguanylate cyclase
DLD53_RS02545	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DLD53_RS02545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLD53_RS02545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLD53_RS02550	COG1105	Belongs to the carbohydrate kinase PfkB family
DLD53_RS02555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLD53_RS02555	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLD53_RS02585	COG0024	Methionine aminopeptidase
DLD53_RS02590	COG0583	DNA-binding transcription factor activity
DLD53_RS02600	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DLD53_RS02605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLD53_RS02610	COG0517	IMP dehydrogenase activity
DLD53_RS02610	COG0516	GMP reductase activity
DLD53_RS02635	COG0552	protein localization to endoplasmic reticulum
DLD53_RS02645	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DLD53_RS02660	COG4890	Cyd operon protein YbgT
DLD53_RS02665	COG1294	oxidase, subunit
DLD53_RS02685	COG1585	Membrane protein implicated in regulation of membrane protease activity
DLD53_RS02695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLD53_RS02700	COG4774	siderophore transport
DLD53_RS02715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DLD53_RS02720	COG0569	domain protein
DLD53_RS02725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLD53_RS02755	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DLD53_RS02760	COG0542	response to heat
DLD53_RS02785	COG1902	pentaerythritol trinitrate reductase activity
DLD53_RS02785	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLD53_RS02830	COG2323	membrane
DLD53_RS02835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DLD53_RS02845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLD53_RS02850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLD53_RS02855	COG0183	Belongs to the thiolase family
DLD53_RS02860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLD53_RS02865	COG0596	Alpha beta hydrolase
DLD53_RS02870	COG2271	Major facilitator Superfamily
DLD53_RS02875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLD53_RS02880	COG3485	protocatechuate 3,4-dioxygenase
DLD53_RS02885	COG3485	protocatechuate 3,4-dioxygenase
DLD53_RS02890	COG0710	3-dehydroquinate dehydratase activity
DLD53_RS02895	COG3420	alginic acid biosynthetic process
DLD53_RS02900	COG3659	wide pore channel activity
DLD53_RS02905	COG4993	Dehydrogenase
DLD53_RS02915	COG2391	methyltransferase activity
DLD53_RS02930	COG1414	Transcriptional regulator
DLD53_RS02935	COG0583	DNA-binding transcription factor activity
DLD53_RS02940	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS02965	COG2814	Major facilitator Superfamily
DLD53_RS02975	COG0154	amidase activity
DLD53_RS02995	COG4638	Rieske (2fe-2S)
DLD53_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLD53_RS03025	COG3733	amine oxidase
DLD53_RS03035	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS03045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLD53_RS03050	COG0183	Belongs to the thiolase family
DLD53_RS03055	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLD53_RS03060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLD53_RS03070	COG4829	muconolactone delta-isomerase
DLD53_RS03075	COG4948	Mandelate Racemase Muconate Lactonizing
DLD53_RS03080	COG0583	DNA-binding transcription factor activity
DLD53_RS03090	COG2186	Transcriptional regulator
DLD53_RS03110	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS03130	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03140	COG3829	transcription factor binding
DLD53_RS03150	COG3162	membrane
DLD53_RS03165	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS03180	COG0753	catalase activity
DLD53_RS03205	COG1846	Transcriptional regulator
DLD53_RS03210	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLD53_RS03210	COG1902	pentaerythritol trinitrate reductase activity
DLD53_RS03220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DLD53_RS03250	COG1309	transcriptional regulator
DLD53_RS03260	COG1335	isochorismatase
DLD53_RS03265	COG0583	DNA-binding transcription factor activity
DLD53_RS03275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLD53_RS03275	COG0475	glutathione-regulated potassium exporter activity
DLD53_RS03285	COG1473	amidohydrolase
DLD53_RS03300	COG2831	hemolysin activation secretion protein
DLD53_RS03305	COG3210	domain, Protein
DLD53_RS03335	COG2188	Transcriptional regulator
DLD53_RS03350	COG0583	DNA-binding transcription factor activity
DLD53_RS03380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLD53_RS03405	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS03430	COG0129	dihydroxy-acid dehydratase activity
DLD53_RS03440	COG0583	DNA-binding transcription factor activity
DLD53_RS03445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLD53_RS03455	COG2084	Dehydrogenase
DLD53_RS03460	COG2207	Transcriptional regulator
DLD53_RS03475	COG1064	alcohol dehydrogenase
DLD53_RS03485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLD53_RS03490	COG1120	ATPase activity
DLD53_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLD53_RS03580	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS03635	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DLD53_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03705	COG2207	Transcriptional regulator
DLD53_RS03715	COG2205	protein histidine kinase activity
DLD53_RS03720	COG0745	RESPONSE REGULATOR receiver
DLD53_RS03725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS03730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DLD53_RS03735	COG1538	Outer membrane efflux protein
DLD53_RS03745	COG2072	flavoprotein involved in K transport
DLD53_RS03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLD53_RS03800	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DLD53_RS03810	COG0753	catalase activity
DLD53_RS03825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DLD53_RS03890	COG1535	isochorismatase
DLD53_RS03890	COG3433	isochorismatase activity
DLD53_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03910	COG4149	molybdate abc transporter
DLD53_RS03915	COG0725	ABC transporter, periplasmic molybdate-binding protein
DLD53_RS03925	COG4638	Rieske (2fe-2S)
DLD53_RS03930	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DLD53_RS03935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLD53_RS03935	COG0543	2 iron, 2 sulfur cluster binding
DLD53_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03975	COG2207	Transcriptional regulator
DLD53_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS03985	COG2610	gluconate transmembrane transporter activity
DLD53_RS03995	COG0583	DNA-binding transcription factor activity
DLD53_RS04005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLD53_RS04010	COG2031	fatty acid transporter
DLD53_RS04015	COG0183	Belongs to the thiolase family
DLD53_RS04020	COG0583	DNA-binding transcription factor activity
DLD53_RS04025	COG0583	DNA-binding transcription factor activity
DLD53_RS04040	COG1027	Aspartate ammonia-lyase
DLD53_RS04050	COG0477	Major facilitator Superfamily
DLD53_RS04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLD53_RS04075	COG4521	taurine ABC transporter
DLD53_RS04090	COG2188	Transcriptional regulator
DLD53_RS04100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DLD53_RS04105	COG1733	regulation of RNA biosynthetic process
DLD53_RS04110	COG3708	Transcriptional regulator
DLD53_RS04110	COG2207	Transcriptional regulator
DLD53_RS04125	COG0730	response to heat
DLD53_RS04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLD53_RS04135	COG3453	Protein conserved in bacteria
DLD53_RS04145	COG3781	membrane
DLD53_RS04150	COG1063	alcohol dehydrogenase
DLD53_RS04160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLD53_RS04165	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLD53_RS04170	COG0022	dehydrogenase e1 component
DLD53_RS04175	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DLD53_RS04180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLD53_RS04195	COG3706	GGDEF domain
DLD53_RS04210	COG0133	tryptophan synthase activity
DLD53_RS04220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DLD53_RS04255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DLD53_RS04280	COG2226	methyltransferase
DLD53_RS04335	COG0842	Transport permease protein
DLD53_RS04340	COG0842	Transport permease protein
DLD53_RS04345	COG1131	(ABC) transporter
DLD53_RS04360	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLD53_RS04365	COG4773	Receptor
DLD53_RS04385	COG0730	response to heat
DLD53_RS04390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DLD53_RS04410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DLD53_RS04470	COG4264	IucA IucC family
DLD53_RS04475	COG4264	IucA IucC family
DLD53_RS04495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DLD53_RS04510	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS04515	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS04520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DLD53_RS04525	COG2207	Transcriptional regulator
DLD53_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DLD53_RS04535	COG0776	regulation of translation
DLD53_RS04560	COG0822	iron-sulfur transferase activity
DLD53_RS04565	COG0316	Belongs to the HesB IscA family
DLD53_RS04595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DLD53_RS04615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLD53_RS04620	COG0702	epimerase
DLD53_RS04655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLD53_RS04665	COG0339	signal peptide processing
DLD53_RS04715	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DLD53_RS04720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DLD53_RS04750	COG0776	regulation of translation
DLD53_RS04815	COG0084	hydrolase, TatD family'
DLD53_RS04835	COG1663	tetraacyldisaccharide 4'-kinase activity
DLD53_RS04840	COG1132	(ABC) transporter
DLD53_RS04850	COG0811	peptide transport
DLD53_RS04855	COG1475	DNA binding
DLD53_RS04860	COG1192	Involved in chromosome partitioning
DLD53_RS04870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLD53_RS04885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DLD53_RS04890	COG0191	fructose-bisphosphate aldolase activity
DLD53_RS04910	COG0424	maF-like protein
DLD53_RS04915	COG2850	peptidyl-arginine hydroxylation
DLD53_RS04925	COG0640	Transcriptional regulator
DLD53_RS04935	COG3619	membrane
DLD53_RS04940	COG3122	Protein conserved in bacteria
DLD53_RS04945	COG1132	(ABC) transporter
DLD53_RS04965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DLD53_RS04970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLD53_RS04980	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLD53_RS04980	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLD53_RS04980	COG0506	proline dehydrogenase activity
DLD53_RS04985	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DLD53_RS05000	COG3698	Phosphodiester glycosidase
DLD53_RS05010	COG2353	YceI-like domain
DLD53_RS05020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DLD53_RS05065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DLD53_RS05065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DLD53_RS05090	COG3539	Fimbrial protein
DLD53_RS05095	COG3121	Chaperone
DLD53_RS05125	COG0697	spore germination
DLD53_RS05135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DLD53_RS05145	COG0583	DNA-binding transcription factor activity
DLD53_RS05165	COG1309	transcriptional regulator
DLD53_RS05180	COG1522	sequence-specific DNA binding
DLD53_RS05190	COG1126	abc transporter atp-binding protein
DLD53_RS05195	COG0765	amino acid transport
DLD53_RS05200	COG0765	amino acid transport
DLD53_RS05230	COG1464	Belongs to the NlpA lipoprotein family
DLD53_RS05240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLD53_RS05245	COG2011	ABC-type metal ion transport system permease component
DLD53_RS05250	COG0012	GTP binding
DLD53_RS05275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DLD53_RS05315	COG0386	Belongs to the glutathione peroxidase family
DLD53_RS05325	COG0436	Aminotransferase
DLD53_RS05365	COG3634	alkyl hydroperoxide reductase activity
DLD53_RS05380	COG0583	DNA-binding transcription factor activity
DLD53_RS05385	COG0798	PFAM Bile acid sodium symporter
DLD53_RS05390	COG0640	Transcriptional regulator
DLD53_RS05405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DLD53_RS05415	COG0583	DNA-binding transcription factor activity
DLD53_RS05425	COG1953	Uracil, thiamine, allantoin
DLD53_RS05435	COG2175	clavaminate synthase activity
DLD53_RS05440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLD53_RS05445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DLD53_RS05450	COG4521	taurine ABC transporter
DLD53_RS05460	COG0477	Major facilitator Superfamily
DLD53_RS05485	COG1271	oxidase subunit
DLD53_RS05490	COG1294	oxidase, subunit
DLD53_RS05500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLD53_RS05520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DLD53_RS05540	COG3052	prosthetic group binding
DLD53_RS05545	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DLD53_RS05555	COG2814	Major facilitator Superfamily
DLD53_RS05575	COG1346	cytolysis
DLD53_RS05585	COG0583	DNA-binding transcription factor activity
DLD53_RS05590	COG0625	glutathione transferase activity
DLD53_RS05595	COG0625	glutathione transferase activity
DLD53_RS05600	COG0583	DNA-binding transcription factor activity
DLD53_RS05615	COG1045	serine acetyltransferase
DLD53_RS05620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLD53_RS05625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLD53_RS05635	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLD53_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLD53_RS05660	COG1126	abc transporter atp-binding protein
DLD53_RS05665	COG0765	amino acid transport
DLD53_RS05670	COG0765	amino acid transport
DLD53_RS05690	COG0784	Response regulator, receiver
DLD53_RS05690	COG2205	protein histidine kinase activity
DLD53_RS05710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DLD53_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS05775	COG0583	DNA-binding transcription factor activity
DLD53_RS05795	COG0318	PFAM AMP-dependent synthetase and ligase
DLD53_RS05800	COG1309	transcriptional regulator
DLD53_RS05805	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS05810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLD53_RS05815	COG1024	Enoyl-CoA hydratase
DLD53_RS05820	COG4770	biotin carboxylase activity
DLD53_RS05830	COG0583	DNA-binding transcription factor activity
DLD53_RS05845	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS05855	COG2814	Major facilitator Superfamily
DLD53_RS05865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLD53_RS05870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLD53_RS05875	COG2814	Major facilitator Superfamily
DLD53_RS05880	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS05895	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLD53_RS05900	COG0183	Belongs to the thiolase family
DLD53_RS05910	COG2814	Major facilitator Superfamily
DLD53_RS05920	COG1024	Enoyl-CoA hydratase
DLD53_RS05935	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS05940	COG2814	Major facilitator Superfamily
DLD53_RS05945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLD53_RS05950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DLD53_RS05965	COG3842	ATPase activity
DLD53_RS05970	COG1840	ABC-type Fe3 transport system, periplasmic component
DLD53_RS05980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLD53_RS05985	COG1414	Transcriptional regulator
DLD53_RS05995	COG0583	DNA-binding transcription factor activity
DLD53_RS06000	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLD53_RS06005	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS06015	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DLD53_RS06025	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS06030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLD53_RS06035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLD53_RS06040	COG2267	carboxylic ester hydrolase activity
DLD53_RS06060	COG3038	cytochrome b561
DLD53_RS06065	COG0753	catalase activity
DLD53_RS06100	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS06115	COG2050	protein possibly involved in aromatic compounds catabolism
DLD53_RS06125	COG3327	negative regulation of DNA-templated transcription, initiation
DLD53_RS06130	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DLD53_RS06135	COG0183	Belongs to the thiolase family
DLD53_RS06140	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLD53_RS06145	COG1024	Enoyl-CoA hydratase
DLD53_RS06150	COG1024	Enoyl-CoA hydratase
DLD53_RS06155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLD53_RS06160	COG2151	metal-sulfur cluster biosynthetic enzyme
DLD53_RS06165	COG3396	Phenylacetate-CoA oxygenase
DLD53_RS06170	COG3460	Phenylacetate-CoA oxygenase
DLD53_RS06175	COG3396	Phenylacetate-CoA oxygenase
DLD53_RS06180	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS06180	COG2030	dehydratase
DLD53_RS06185	COG1760	l-serine dehydratase
DLD53_RS06190	COG0531	amino acid
DLD53_RS06195	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS06210	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLD53_RS06220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLD53_RS06240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLD53_RS06260	COG0789	Transcriptional regulator
DLD53_RS06270	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DLD53_RS06275	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS06290	COG2807	transmembrane transport
DLD53_RS06295	COG0590	tRNA wobble adenosine to inosine editing
DLD53_RS06370	COG2746	aminoglycoside 3-N-acetyltransferase activity
DLD53_RS06375	COG1660	Displays ATPase and GTPase activities
DLD53_RS06480	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLD53_RS06500	COG2814	Major facilitator Superfamily
DLD53_RS06510	COG1560	Kdo2-lipid A biosynthetic process
DLD53_RS06520	COG5006	permease, DMT superfamily
DLD53_RS06525	COG1522	sequence-specific DNA binding
DLD53_RS06540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DLD53_RS06550	COG4122	O-methyltransferase activity
DLD53_RS06580	COG1538	Outer membrane efflux protein
DLD53_RS06585	COG1137	ATPase activity
DLD53_RS06590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DLD53_RS06600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DLD53_RS06605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DLD53_RS06605	COG0517	IMP dehydrogenase activity
DLD53_RS06645	COG2814	Major facilitator Superfamily
DLD53_RS06685	COG1278	Cold shock
DLD53_RS06690	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS06725	COG1570	exodeoxyribonuclease VII activity
DLD53_RS06815	COG2871	sodium ion transport
DLD53_RS06825	COG0583	DNA-binding transcription factor activity
DLD53_RS06830	COG4638	Rieske (2fe-2S)
DLD53_RS06835	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DLD53_RS06840	COG0633	Ferredoxin
DLD53_RS06840	COG0543	2 iron, 2 sulfur cluster binding
DLD53_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS06850	COG3135	benzoate transporter
DLD53_RS06860	COG2015	COG2015, Alkyl sulfatase and related hydrolases
DLD53_RS06865	COG2814	Major facilitator Superfamily
DLD53_RS06880	COG1643	Atp-dependent helicase
DLD53_RS06885	COG0450	alkyl hydroperoxide reductase
DLD53_RS06895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DLD53_RS06905	COG3634	alkyl hydroperoxide reductase activity
DLD53_RS06925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DLD53_RS06930	COG0625	glutathione transferase activity
DLD53_RS06940	COG2885	chlorophyll binding
DLD53_RS06975	COG0542	response to heat
DLD53_RS06990	COG1765	OsmC-like protein
DLD53_RS07000	COG0667	Aldo Keto reductase
DLD53_RS07010	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS07020	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DLD53_RS07030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLD53_RS07040	COG0527	aspartate kinase activity
DLD53_RS07050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DLD53_RS07060	COG3038	cytochrome b561
DLD53_RS07065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLD53_RS07070	COG2252	PERMEase
DLD53_RS07080	COG2072	flavoprotein involved in K transport
DLD53_RS07095	COG1741	Belongs to the pirin family
DLD53_RS07100	COG1309	transcriptional regulator
DLD53_RS07125	COG1113	amino acid transport
DLD53_RS07145	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS07165	COG0531	amino acid
DLD53_RS07175	COG1113	amino acid transport
DLD53_RS07220	COG3209	COG3209 Rhs family protein
DLD53_RS07250	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS07270	COG1902	pentaerythritol trinitrate reductase activity
DLD53_RS07270	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLD53_RS07280	COG2203	Gaf domain
DLD53_RS07280	COG5001	Diguanylate cyclase
DLD53_RS07280	COG4251	negative regulation of phosphorylation
DLD53_RS07280	COG3706	GGDEF domain
DLD53_RS07290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLD53_RS07310	COG4172	Belongs to the ABC transporter superfamily
DLD53_RS07315	COG4239	(ABC) transporter, permease
DLD53_RS07320	COG4174	ABC transporter (Permease)
DLD53_RS07330	COG0741	lytic transglycosylase activity
DLD53_RS07330	COG1388	LysM domain
DLD53_RS07330	COG0741	lytic transglycosylase activity
DLD53_RS07330	COG1388	LysM domain
DLD53_RS07335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLD53_RS07375	COG0583	DNA-binding transcription factor activity
DLD53_RS07380	COG1279	arginine transmembrane transporter activity
DLD53_RS07400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLD53_RS07405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLD53_RS07410	COG0006	proline dipeptidase activity
DLD53_RS07445	COG2194	sulfuric ester hydrolase activity
DLD53_RS07805	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DLD53_RS07830	COG3384	dioxygenase
DLD53_RS07840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLD53_RS07845	COG2878	Part of a membrane complex involved in electron transport
DLD53_RS07850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DLD53_RS07875	COG0768	penicillin binding
DLD53_RS07880	COG0742	ribosomal rna small subunit methyltransferase
DLD53_RS07895	COG0830	nickel cation binding
DLD53_RS07905	COG0804	urea catabolic process
DLD53_RS07945	COG1253	flavin adenine dinucleotide binding
DLD53_RS07955	COG2851	Citrate transporter
DLD53_RS08010	COG1773	rubredoxin
DLD53_RS08015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLD53_RS08025	COG0583	DNA-binding transcription factor activity
DLD53_RS08050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DLD53_RS08055	COG4181	ATPase activity
DLD53_RS08100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLD53_RS08120	COG0306	phosphate transporter
DLD53_RS08130	COG3958	Transketolase
DLD53_RS08135	COG3959	Transketolase, thiamine diphosphate binding domain
DLD53_RS08140	COG2271	Major facilitator Superfamily
DLD53_RS08145	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS08150	COG0583	DNA-binding transcription factor activity
DLD53_RS08170	COG2223	nitrite transmembrane transporter activity
DLD53_RS08175	COG2207	Transcriptional regulator
DLD53_RS08180	COG2066	Belongs to the glutaminase family
DLD53_RS08185	COG0242	peptide deformylase activity
DLD53_RS08190	COG0477	Major facilitator Superfamily
DLD53_RS08200	COG0028	Belongs to the TPP enzyme family
DLD53_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS08220	COG2267	carboxylic ester hydrolase activity
DLD53_RS08230	COG2271	Major facilitator Superfamily
DLD53_RS08235	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLD53_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS08265	COG1414	Transcriptional regulator
DLD53_RS08280	COG1024	Enoyl-CoA hydratase
DLD53_RS08290	COG1215	transferase activity, transferring glycosyl groups
DLD53_RS08295	COG1649	PFAM Uncharacterised BCR, COG1649
DLD53_RS08295	COG0726	polysaccharide deacetylase
DLD53_RS08305	COG4681	YaeQ
DLD53_RS08315	COG0523	cobalamin synthesis protein
DLD53_RS08325	COG1607	acyl-coa hydrolase
DLD53_RS08335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLD53_RS08340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLD53_RS08345	COG1309	transcriptional regulator
DLD53_RS08370	COG2040	homocysteine
DLD53_RS08375	COG0531	amino acid
DLD53_RS08400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLD53_RS08405	COG0477	Major facilitator Superfamily
DLD53_RS08470	COG0405	Gamma-glutamyltransferase
DLD53_RS08475	COG2814	Major facilitator Superfamily
DLD53_RS08485	COG2050	protein possibly involved in aromatic compounds catabolism
DLD53_RS08500	COG1090	epimerase
DLD53_RS08520	COG0420	3'-5' exonuclease activity
DLD53_RS08545	COG0735	belongs to the Fur family
DLD53_RS08550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DLD53_RS08575	COG0121	glutamine amidotransferase
DLD53_RS08590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLD53_RS08600	COG0210	DNA helicase
DLD53_RS08605	COG2885	chlorophyll binding
DLD53_RS08610	COG0204	Acyl-transferase
DLD53_RS08625	COG2894	cell division
DLD53_RS08645	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS08650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DLD53_RS08650	COG1674	ftsk spoiiie
DLD53_RS08655	COG0492	ferredoxin-NADP+ reductase activity
DLD53_RS08660	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DLD53_RS08670	COG0456	acetyltransferase
DLD53_RS08715	COG1981	membrane
DLD53_RS08730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLD53_RS08730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DLD53_RS08750	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS08760	COG0657	acetylesterase activity
DLD53_RS08770	COG0473	3-isopropylmalate dehydrogenase activity
DLD53_RS08775	COG0583	DNA-binding transcription factor activity
DLD53_RS08795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DLD53_RS08820	COG0564	pseudouridine synthase activity
DLD53_RS08830	COG0358	DNA primase activity
DLD53_RS08845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DLD53_RS08875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLD53_RS08905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DLD53_RS08915	COG0352	thiamine-phosphate diphosphorylase activity
DLD53_RS08915	COG0351	phosphomethylpyrimidine kinase
DLD53_RS08915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DLD53_RS08920	COG1652	LysM domain
DLD53_RS08945	COG1399	metal-binding, possibly nucleic acid-binding protein
DLD53_RS08950	COG3101	peptidyl-lysine hydroxylation
DLD53_RS08955	COG0009	L-threonylcarbamoyladenylate synthase
DLD53_RS08960	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DLD53_RS08965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DLD53_RS08980	COG4106	trans-aconitate 2-methyltransferase activity
DLD53_RS08995	COG2226	methyltransferase
DLD53_RS08995	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLD53_RS08995	COG0596	Alpha beta hydrolase
DLD53_RS09000	COG1877	trehalose-phosphatase activity
DLD53_RS09005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DLD53_RS09010	COG2223	nitrite transmembrane transporter activity
DLD53_RS09030	COG1196	nuclear chromosome segregation
DLD53_RS09040	COG0730	response to heat
DLD53_RS09055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DLD53_RS09065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DLD53_RS09125	COG0489	protein tyrosine kinase activity
DLD53_RS09135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLD53_RS09135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLD53_RS09165	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DLD53_RS09170	COG2081	HI0933 family
DLD53_RS09180	COG0668	transmembrane transport
DLD53_RS09200	COG0583	DNA-binding transcription factor activity
DLD53_RS09220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLD53_RS09225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DLD53_RS09255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLD53_RS09295	COG0745	RESPONSE REGULATOR receiver
DLD53_RS09315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLD53_RS09330	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS09405	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS09420	COG4993	Dehydrogenase
DLD53_RS09440	COG0384	phenazine biosynthesis protein PhzF
DLD53_RS09460	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS09480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLD53_RS09495	COG0583	DNA-binding transcription factor activity
DLD53_RS09525	COG0583	DNA-binding transcription factor activity
DLD53_RS09545	COG0583	DNA-binding transcription factor activity
DLD53_RS09550	COG1053	succinate dehydrogenase
DLD53_RS09560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLD53_RS09565	COG2814	Major facilitator Superfamily
DLD53_RS09575	COG0583	DNA-binding transcription factor activity
DLD53_RS09580	COG1063	alcohol dehydrogenase
DLD53_RS09610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DLD53_RS09615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DLD53_RS09620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLD53_RS09635	COG3667	copper resistance
DLD53_RS09640	COG2132	Multicopper oxidase
DLD53_RS09650	COG0561	phosphatase activity
DLD53_RS09655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DLD53_RS09680	COG1214	PFAM Peptidase M22, glycoprotease
DLD53_RS09730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLD53_RS09740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DLD53_RS09745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DLD53_RS09750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DLD53_RS09810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLD53_RS09820	COG1846	Transcriptional regulator
DLD53_RS09825	COG1764	response to oxidative stress
DLD53_RS09865	COG0037	tRNA processing
DLD53_RS09875	COG0248	Ppx GppA phosphatase
DLD53_RS09905	COG0072	phenylalanine-tRNA ligase activity
DLD53_RS09945	COG1238	metal cluster binding
DLD53_RS09950	COG0625	glutathione transferase activity
DLD53_RS09970	COG0318	PFAM AMP-dependent synthetase and ligase
DLD53_RS09975	COG3028	Belongs to the UPF0307 family
DLD53_RS09980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLD53_RS10000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DLD53_RS10005	COG0617	tRNA 3'-terminal CCA addition
DLD53_RS10010	COG1555	photosystem II stabilization
DLD53_RS10015	COG3956	TIGRFAM MazG family protein
DLD53_RS10025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLD53_RS10045	COG5002	protein histidine kinase activity
DLD53_RS10045	COG0784	Response regulator, receiver
DLD53_RS10045	COG2205	protein histidine kinase activity
DLD53_RS10050	COG1024	Enoyl-CoA hydratase
DLD53_RS10055	COG2084	Dehydrogenase
DLD53_RS10060	COG3622	Belongs to the hyi family
DLD53_RS10090	COG0697	spore germination
DLD53_RS10100	COG2814	Major facilitator Superfamily
DLD53_RS10105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DLD53_RS10115	COG0583	DNA-binding transcription factor activity
DLD53_RS10125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DLD53_RS10140	COG0084	hydrolase, TatD family'
DLD53_RS10155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DLD53_RS10195	COG0440	acetolactate synthase activity
DLD53_RS10200	COG0028	Belongs to the TPP enzyme family
DLD53_RS10225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS10230	COG0577	efflux transmembrane transporter activity
DLD53_RS10230	COG1136	(ABC) transporter
DLD53_RS10235	COG1538	Outer membrane efflux protein
DLD53_RS10250	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DLD53_RS10255	COG1162	GTPase activity
DLD53_RS10265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DLD53_RS10285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DLD53_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS10330	COG2986	histidine ammonia-lyase
DLD53_RS10345	COG0318	PFAM AMP-dependent synthetase and ligase
DLD53_RS10355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLD53_RS10400	COG1426	Protein conserved in bacteria
DLD53_RS10435	COG0793	Belongs to the peptidase S41A family
DLD53_RS10450	COG2267	carboxylic ester hydrolase activity
DLD53_RS10460	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS10465	COG3265	gluconokinase activity
DLD53_RS10475	COG0800	Aldolase
DLD53_RS10485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DLD53_RS10490	COG0857	belongs to the CobB CobQ family
DLD53_RS10490	COG0280	phosphate acetyltransferase
DLD53_RS10495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DLD53_RS10495	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DLD53_RS10515	COG0740	serine-type endopeptidase activity
DLD53_RS10525	COG4774	siderophore transport
DLD53_RS10535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLD53_RS10545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLD53_RS10545	COG2813	Specifically methylates the guanine in position
DLD53_RS10645	COG0788	formyltetrahydrofolate deformylase activity
DLD53_RS10670	COG4651	solute:proton antiporter activity
DLD53_RS10670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLD53_RS10690	COG0724	RNA recognition motif
DLD53_RS10695	COG0210	DNA helicase
DLD53_RS10720	COG1733	regulation of RNA biosynthetic process
DLD53_RS10730	COG2900	Belongs to the SlyX family
DLD53_RS10735	COG0488	(ABC) transporter
DLD53_RS10740	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS10745	COG1560	Kdo2-lipid A biosynthetic process
DLD53_RS10755	COG1301	dicarboxylic acid transport
DLD53_RS10810	COG0473	3-isopropylmalate dehydrogenase activity
DLD53_RS10875	COG0583	DNA-binding transcription factor activity
DLD53_RS10885	COG0625	glutathione transferase activity
DLD53_RS10890	COG2378	regulation of single-species biofilm formation
DLD53_RS10895	COG0546	phosphoglycolate phosphatase activity
DLD53_RS10910	COG1530	ribonuclease E activity
DLD53_RS10915	COG0318	PFAM AMP-dependent synthetase and ligase
DLD53_RS10930	COG0583	DNA-binding transcription factor activity
DLD53_RS10935	COG4221	oxidoreductase activity
DLD53_RS10940	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DLD53_RS10950	COG0534	Mate efflux family protein
DLD53_RS10965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DLD53_RS11005	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DLD53_RS11010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLD53_RS11025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLD53_RS11035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DLD53_RS11035	COG0644	oxidoreductase
DLD53_RS11040	COG0425	Belongs to the sulfur carrier protein TusA family
DLD53_RS11045	COG4535	Mg2 and Co2 transporter CorC
DLD53_RS11055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLD53_RS11075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DLD53_RS11080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLD53_RS11080	COG0475	glutathione-regulated potassium exporter activity
DLD53_RS11085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DLD53_RS11095	COG0484	heat shock protein binding
DLD53_RS11100	COG0789	Transcriptional regulator
DLD53_RS11105	COG0598	Magnesium transport protein CorA
DLD53_RS11120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLD53_RS11125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DLD53_RS11130	COG1074	ATP-dependent DNA helicase activity
DLD53_RS11135	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DLD53_RS11155	COG2226	methyltransferase
DLD53_RS11170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLD53_RS11175	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DLD53_RS11190	COG2111	Na H antiporter
DLD53_RS11190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DLD53_RS11195	COG1006	Multisubunit Na H antiporter MnhC subunit
DLD53_RS11200	COG0651	ATP synthesis coupled electron transport
DLD53_RS11205	COG1863	multisubunit Na H antiporter MnhE subunit
DLD53_RS11210	COG2212	antiporter activity
DLD53_RS11215	COG1320	monovalent cation:proton antiporter activity
DLD53_RS11230	COG0195	Participates in both transcription termination and antitermination
DLD53_RS11280	COG0237	dephospho-CoA kinase activity
DLD53_RS11290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLD53_RS11305	COG0497	DNA recombination
DLD53_RS11315	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DLD53_RS11345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLD53_RS11345	COG2169	Transcriptional regulator
DLD53_RS11350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLD53_RS11375	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS11420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DLD53_RS11435	COG0326	Molecular chaperone. Has ATPase activity
DLD53_RS11450	COG2056	Na+-H+ antiporter family
DLD53_RS11455	COG0596	Alpha beta hydrolase
DLD53_RS11550	COG0546	phosphoglycolate phosphatase activity
DLD53_RS11555	COG1716	ATPase activity
DLD53_RS11600	COG0181	hydroxymethylbilane synthase activity
DLD53_RS11610	COG3275	phosphorelay sensor kinase activity
DLD53_RS11630	COG1538	Outer membrane efflux protein
DLD53_RS11635	COG0697	spore germination
DLD53_RS11660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLD53_RS11665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DLD53_RS11670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLD53_RS11675	COG0772	Belongs to the SEDS family
DLD53_RS11700	COG4974	Belongs to the 'phage' integrase family
DLD53_RS11705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLD53_RS11715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DLD53_RS11725	COG2197	response regulator
DLD53_RS11740	COG0793	Belongs to the peptidase S41A family
DLD53_RS11745	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DLD53_RS11750	COG0795	lipopolysaccharide-transporting ATPase activity
DLD53_RS11790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLD53_RS11790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLD53_RS11800	COG0004	ammonium transporteR
DLD53_RS11805	COG0347	Belongs to the P(II) protein family
DLD53_RS11815	COG0606	chelatase, subunit chli
DLD53_RS11870	COG0659	secondary active sulfate transmembrane transporter activity
DLD53_RS11875	COG0589	response to stress
DLD53_RS11905	COG0606	chelatase, subunit chli
DLD53_RS11910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLD53_RS11920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLD53_RS11935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DLD53_RS11950	COG0318	PFAM AMP-dependent synthetase and ligase
DLD53_RS11960	COG0477	Major facilitator Superfamily
DLD53_RS11965	COG2860	membrane
DLD53_RS11975	COG1253	flavin adenine dinucleotide binding
DLD53_RS11985	COG2814	Major facilitator Superfamily
DLD53_RS11995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLD53_RS12030	COG0655	NAD(P)H dehydrogenase (quinone) activity
DLD53_RS12040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DLD53_RS12075	COG1309	transcriptional regulator
DLD53_RS12110	COG0758	DNA mediated transformation
DLD53_RS12120	COG0697	spore germination
DLD53_RS12125	COG1309	transcriptional regulator
DLD53_RS12140	COG0386	Belongs to the glutathione peroxidase family
DLD53_RS12205	COG1121	(ABC) transporter
DLD53_RS12210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DLD53_RS12215	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS12220	COG2837	iron assimilation
DLD53_RS12230	COG0281	malic enzyme
DLD53_RS12275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLD53_RS12275	COG0519	Catalyzes the synthesis of GMP from XMP
DLD53_RS12280	COG4399	Belongs to the UPF0754 family
DLD53_RS12285	COG2259	Doxx family
DLD53_RS12290	COG0586	Pfam SNARE associated Golgi protein
DLD53_RS12305	COG1192	Involved in chromosome partitioning
DLD53_RS12315	COG0271	Belongs to the BolA IbaG family
DLD53_RS12335	COG2267	carboxylic ester hydrolase activity
DLD53_RS12355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLD53_RS12355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLD53_RS12355	COG3321	synthase
DLD53_RS12355	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DLD53_RS12360	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS12370	COG2197	response regulator
DLD53_RS12380	COG3916	Acyl-homoserine-lactone synthase
DLD53_RS12385	COG0477	Major facilitator Superfamily
DLD53_RS12390	COG1024	Enoyl-CoA hydratase
DLD53_RS12395	COG1024	Enoyl-CoA hydratase
DLD53_RS12400	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS12405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLD53_RS12425	COG1113	amino acid transport
DLD53_RS12430	COG1113	amino acid transport
DLD53_RS12435	COG0251	oxidation-reduction process
DLD53_RS12475	COG0564	pseudouridine synthase activity
DLD53_RS12505	COG1051	belongs to the nudix hydrolase family
DLD53_RS12525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DLD53_RS12540	COG1802	Transcriptional regulator
DLD53_RS12550	COG1448	Aminotransferase
DLD53_RS12555	COG0277	FAD linked oxidase domain protein
DLD53_RS12565	COG2186	Transcriptional regulator
DLD53_RS12575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLD53_RS12580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DLD53_RS12595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DLD53_RS12600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DLD53_RS12605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DLD53_RS12660	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DLD53_RS12665	COG1596	polysaccharide export
DLD53_RS12690	COG0728	peptidoglycan biosynthetic process
DLD53_RS12695	COG3023	N-Acetylmuramoyl-L-alanine amidase
DLD53_RS12755	COG0546	phosphoglycolate phosphatase activity
DLD53_RS12760	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS12780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLD53_RS12785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLD53_RS12790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLD53_RS12795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLD53_RS12800	COG1116	anion transmembrane transporter activity
DLD53_RS12805	COG1309	transcriptional regulator
DLD53_RS12810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DLD53_RS12820	COG0196	riboflavin kinase activity
DLD53_RS12825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DLD53_RS12835	COG1047	Peptidyl-prolyl cis-trans
DLD53_RS12880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DLD53_RS12885	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DLD53_RS12890	COG0596	Alpha beta hydrolase
DLD53_RS12915	COG0488	(ABC) transporter
DLD53_RS12920	COG0586	Pfam SNARE associated Golgi protein
DLD53_RS12930	COG0187	DNA topoisomerase II activity
DLD53_RS12940	COG0592	DNA-directed DNA polymerase activity
DLD53_RS12965	COG0706	membrane insertase activity
DLD53_RS12980	COG1230	cation diffusion facilitator family transporter
DLD53_RS12985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLD53_RS13000	COG0402	S-adenosylhomocysteine deaminase activity
DLD53_RS13010	COG0754	glutathionylspermidine amidase activity
DLD53_RS13025	COG0861	Integral membrane protein TerC family
DLD53_RS13030	COG0671	phosphoesterase, PA-phosphatase related
DLD53_RS13040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DLD53_RS13060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DLD53_RS13065	COG2951	lytic endotransglycosylase activity
DLD53_RS13115	COG0657	acetylesterase activity
DLD53_RS13120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DLD53_RS13210	COG2233	PERMEase
DLD53_RS13225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS13260	COG2814	Major facilitator Superfamily
DLD53_RS13265	COG0656	L-ascorbic acid biosynthetic process
DLD53_RS13270	COG0583	DNA-binding transcription factor activity
DLD53_RS13285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLD53_RS13290	COG1064	alcohol dehydrogenase
DLD53_RS13295	COG2818	Glycosylase
DLD53_RS13310	COG1194	a g-specific adenine glycosylase
DLD53_RS13330	COG2983	Belongs to the UPF0260 family
DLD53_RS13335	COG2133	pyrroloquinoline quinone binding
DLD53_RS13340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DLD53_RS13345	COG2116	formate transmembrane transporter activity
DLD53_RS13370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLD53_RS13375	COG1335	isochorismatase
DLD53_RS13380	COG0385	Bile acid
DLD53_RS13385	COG0534	Mate efflux family protein
DLD53_RS13390	COG1683	Conserved Protein
DLD53_RS13410	COG0625	glutathione transferase activity
DLD53_RS13420	COG1113	amino acid transport
DLD53_RS13430	COG0523	cobalamin synthesis protein
DLD53_RS13440	COG2188	Transcriptional regulator
DLD53_RS13470	COG0010	Belongs to the arginase family
DLD53_RS13480	COG0546	phosphoglycolate phosphatase activity
DLD53_RS13485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLD53_RS13490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLD53_RS13500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DLD53_RS13505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DLD53_RS13555	COG0753	catalase activity
DLD53_RS13615	COG0534	Mate efflux family protein
DLD53_RS13620	COG0436	Aminotransferase
DLD53_RS13625	COG2733	membrane
DLD53_RS13640	COG2918	glutathione biosynthetic process
DLD53_RS13655	COG3179	chitinase
DLD53_RS13680	COG3150	esterase
DLD53_RS13690	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DLD53_RS13700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLD53_RS13710	COG2233	PERMEase
DLD53_RS13765	COG1393	Belongs to the ArsC family
DLD53_RS13770	COG0708	Exodeoxyribonuclease III
DLD53_RS13790	COG0189	ligase activity
DLD53_RS13810	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DLD53_RS13820	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DLD53_RS13835	COG4942	peptidase
DLD53_RS13845	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLD53_RS13855	COG2119	membrane
DLD53_RS13865	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS13875	COG0426	domain, Protein
DLD53_RS13875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLD53_RS13900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DLD53_RS13920	COG1902	pentaerythritol trinitrate reductase activity
DLD53_RS13930	COG1519	Transferase
DLD53_RS13935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLD53_RS13940	COG0668	transmembrane transport
DLD53_RS13950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLD53_RS13955	COG1335	isochorismatase
DLD53_RS13960	COG1522	sequence-specific DNA binding
DLD53_RS13985	COG2205	protein histidine kinase activity
DLD53_RS13985	COG2198	Histidine kinase
DLD53_RS13985	COG0784	Response regulator, receiver
DLD53_RS13990	COG3162	membrane
DLD53_RS13995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLD53_RS14005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLD53_RS14020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLD53_RS14025	COG1309	transcriptional regulator
DLD53_RS14045	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DLD53_RS14045	COG0351	phosphomethylpyrimidine kinase
DLD53_RS14045	COG0352	thiamine-phosphate diphosphorylase activity
DLD53_RS14055	COG2814	Major facilitator Superfamily
DLD53_RS14070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DLD53_RS14080	COG1113	amino acid transport
DLD53_RS14090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLD53_RS14095	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS14105	COG1335	isochorismatase
DLD53_RS14135	COG2814	Major facilitator Superfamily
DLD53_RS14140	COG0583	DNA-binding transcription factor activity
DLD53_RS14165	COG0667	Aldo Keto reductase
DLD53_RS14190	COG1733	regulation of RNA biosynthetic process
DLD53_RS14205	COG1733	regulation of RNA biosynthetic process
DLD53_RS14215	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLD53_RS14230	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DLD53_RS14235	COG2207	Transcriptional regulator
DLD53_RS14290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DLD53_RS14330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DLD53_RS14360	COG0427	acetyl-CoA hydrolase
DLD53_RS14385	COG0659	secondary active sulfate transmembrane transporter activity
DLD53_RS14390	COG4221	oxidoreductase activity
DLD53_RS14395	COG2873	o-acetylhomoserine
DLD53_RS14400	COG0488	(ABC) transporter
DLD53_RS14465	COG0833	amino acid
DLD53_RS14510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DLD53_RS14515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DLD53_RS14530	COG2226	methyltransferase
DLD53_RS14580	COG0069	glutamate synthase activity
DLD53_RS14580	COG0070	glutamate synthase
DLD53_RS14580	COG0067	glutamate synthase
DLD53_RS14585	COG0493	'glutamate synthase
DLD53_RS14595	COG1704	LemA family
DLD53_RS14600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DLD53_RS14620	COG3307	-O-antigen
DLD53_RS14640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLD53_RS14655	COG0194	GDP metabolic process
DLD53_RS14710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DLD53_RS14730	COG5380	lipid catabolic process
DLD53_RS14735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DLD53_RS14760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLD53_RS14765	COG0277	FAD linked oxidase domain protein
DLD53_RS14775	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DLD53_RS14780	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLD53_RS14795	COG1289	transmembrane transporter activity
DLD53_RS14805	COG0628	permease
DLD53_RS14810	COG1192	Involved in chromosome partitioning
DLD53_RS14840	COG0833	amino acid
DLD53_RS14845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLD53_RS14850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLD53_RS14860	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS14900	COG0583	DNA-binding transcription factor activity
DLD53_RS14945	COG0517	IMP dehydrogenase activity
DLD53_RS14950	COG1983	PspC domain protein
DLD53_RS14960	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS14975	COG0408	coproporphyrinogen oxidase activity
DLD53_RS14995	COG0513	Belongs to the DEAD box helicase family
DLD53_RS15000	COG1127	ABC transporter
DLD53_RS15005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DLD53_RS15015	COG2854	intermembrane phospholipid transfer
DLD53_RS15025	COG0598	Magnesium transport protein CorA
DLD53_RS15035	COG0494	nUDIX hydrolase
DLD53_RS15040	COG1040	competence protein
DLD53_RS15045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DLD53_RS15065	COG1946	Acyl-CoA thioesterase
DLD53_RS15070	COG1301	dicarboxylic acid transport
DLD53_RS15085	COG1959	2 iron, 2 sulfur cluster binding
DLD53_RS15090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLD53_RS15090	COG1017	nitric oxide dioxygenase activity
DLD53_RS15095	COG0433	COG0433 Predicted ATPase
DLD53_RS15100	COG0626	cystathionine gamma-synthase activity
DLD53_RS15255	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS15260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DLD53_RS15290	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DLD53_RS15295	COG0339	signal peptide processing
DLD53_RS15300	COG0557	exoribonuclease II activity
DLD53_RS15340	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLD53_RS15345	COG2169	Transcriptional regulator
DLD53_RS15350	COG0697	spore germination
DLD53_RS15355	COG1295	ribonuclease BN
DLD53_RS15390	COG1702	phosphate starvation-inducible protein PhoH
DLD53_RS15400	COG0739	heme binding
DLD53_RS15400	COG0741	lytic transglycosylase activity
DLD53_RS15400	COG1196	nuclear chromosome segregation
DLD53_RS15430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DLD53_RS15435	COG1183	phosphatidylcholine synthase activity
DLD53_RS15480	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS15485	COG1309	transcriptional regulator
DLD53_RS15500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLD53_RS15505	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS15525	COG2969	positive regulation of protein catabolic process
DLD53_RS15535	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DLD53_RS15550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DLD53_RS15555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DLD53_RS15575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DLD53_RS15585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DLD53_RS15590	COG1408	metallophosphoesterase
DLD53_RS15600	COG2199	diguanylate cyclase activity
DLD53_RS15610	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS15665	COG1607	acyl-coa hydrolase
DLD53_RS15695	COG2350	Protein conserved in bacteria
DLD53_RS15705	COG0613	PHP domain protein
DLD53_RS15710	COG3781	membrane
DLD53_RS15720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DLD53_RS15725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLD53_RS15735	COG1862	Preprotein translocase
DLD53_RS15765	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS15785	COG2205	protein histidine kinase activity
DLD53_RS15790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DLD53_RS15810	COG0726	polysaccharide deacetylase
DLD53_RS15815	COG0463	Glycosyl transferase, family 2
DLD53_RS15820	COG0438	transferase activity, transferring glycosyl groups
DLD53_RS15895	COG0625	glutathione transferase activity
DLD53_RS15900	COG0583	DNA-binding transcription factor activity
DLD53_RS15905	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS15910	COG1960	acyl-CoA dehydrogenase activity
DLD53_RS15920	COG2205	protein histidine kinase activity
DLD53_RS15925	COG0745	RESPONSE REGULATOR receiver
DLD53_RS15930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DLD53_RS15950	COG2096	Adenosyltransferase
DLD53_RS16000	COG0285	dihydrofolate synthase activity
DLD53_RS16020	COG0450	alkyl hydroperoxide reductase
DLD53_RS16035	COG0477	Major facilitator Superfamily
DLD53_RS16040	COG1272	protein, Hemolysin III
DLD53_RS16070	COG0183	Belongs to the thiolase family
DLD53_RS16075	COG2207	Transcriptional regulator
DLD53_RS16095	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLD53_RS16115	COG0183	Belongs to the thiolase family
DLD53_RS16125	COG2885	chlorophyll binding
DLD53_RS16125	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DLD53_RS16135	COG1690	Belongs to the RtcB family
DLD53_RS16140	COG0833	amino acid
DLD53_RS16155	COG1217	gtp-binding protein TYPA
DLD53_RS16180	COG2094	Belongs to the DNA glycosylase MPG family
DLD53_RS16185	COG4772	TonB-dependent receptor
DLD53_RS16190	COG1902	pentaerythritol trinitrate reductase activity
DLD53_RS16205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLD53_RS16210	COG0354	folic acid binding
DLD53_RS16220	COG3189	MarR family transcriptional regulator
DLD53_RS16225	COG2824	Alkylphosphonate utilization operon protein PhnA
DLD53_RS16230	COG3422	double-strand break repair
DLD53_RS16270	COG0840	transmembrane signaling receptor activity
DLD53_RS16290	COG5510	response to toxic substance
DLD53_RS16300	COG2832	Protein of unknown function (DUF454)
DLD53_RS16305	COG1376	ErfK ybiS ycfS ynhG family protein
DLD53_RS16345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DLD53_RS16355	COG1289	transmembrane transporter activity
DLD53_RS16360	COG2814	Major facilitator Superfamily
DLD53_RS16380	COG1115	amino acid carrier protein
DLD53_RS16385	COG1752	Esterase of the alpha-beta hydrolase superfamily
DLD53_RS16390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLD53_RS16395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DLD53_RS16425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLD53_RS16435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLD53_RS16440	COG1077	Cell shape determining protein MreB Mrl
DLD53_RS16445	COG1792	Involved in formation and maintenance of cell shape
DLD53_RS16450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DLD53_RS16455	COG0424	maF-like protein
DLD53_RS16460	COG1530	ribonuclease E activity
DLD53_RS16470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLD53_RS16480	COG0560	Phosphoserine phosphatase
DLD53_RS16490	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLD53_RS16515	COG2207	Transcriptional regulator
DLD53_RS16940	COG0582	viral genome integration into host DNA
DLD53_RS16950	COG1113	amino acid transport
DLD53_RS16955	COG2828	Protein conserved in bacteria
DLD53_RS16960	COG0142	geranyltranstransferase activity
DLD53_RS16965	COG2315	Protein conserved in bacteria
DLD53_RS16980	COG1752	Esterase of the alpha-beta hydrolase superfamily
DLD53_RS17000	COG2194	sulfuric ester hydrolase activity
DLD53_RS17005	COG0745	RESPONSE REGULATOR receiver
DLD53_RS17010	COG0642	Histidine kinase
DLD53_RS17020	COG0004	ammonium transporteR
DLD53_RS17030	COG0583	DNA-binding transcription factor activity
DLD53_RS17050	COG0525	valine-tRNA ligase activity
DLD53_RS17060	COG1028	Short-chain dehydrogenase reductase Sdr
DLD53_RS17070	COG0393	Putative heavy-metal-binding
DLD53_RS17075	COG0393	Putative heavy-metal-binding
DLD53_RS17080	COG1538	Outer membrane efflux protein
DLD53_RS17090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS17095	COG0671	phosphoesterase, PA-phosphatase related
DLD53_RS17125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DLD53_RS17140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DLD53_RS17140	COG1648	precorrin-2 dehydrogenase activity
DLD53_RS17145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DLD53_RS17150	COG1733	regulation of RNA biosynthetic process
DLD53_RS17160	COG0531	amino acid
DLD53_RS17175	COG0321	lipoyl(octanoyl) transferase activity
DLD53_RS17180	COG2921	Belongs to the UPF0250 family
DLD53_RS17220	COG2009	succinate dehydrogenase
DLD53_RS17225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DLD53_RS17230	COG1053	succinate dehydrogenase
DLD53_RS17235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DLD53_RS17260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLD53_RS17280	COG2354	Protein conserved in bacteria
DLD53_RS17285	COG2321	neutral zinc metallopeptidase
DLD53_RS17335	COG2843	Capsule synthesis protein
DLD53_RS17350	COG0589	response to stress
DLD53_RS17370	COG0505	Belongs to the CarA family
DLD53_RS17395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DLD53_RS17400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DLD53_RS17450	COG0477	Major facilitator Superfamily
DLD53_RS17455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLD53_RS17470	COG1597	lipid kinase activity
DLD53_RS17475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLD53_RS17500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLD53_RS17505	COG0584	glycerophosphoryl diester phosphodiesterase
DLD53_RS17525	COG0741	lytic transglycosylase activity
DLD53_RS17550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DLD53_RS17565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLD53_RS17595	COG0778	Nitroreductase
DLD53_RS17610	COG1929	Belongs to the glycerate kinase type-1 family
DLD53_RS17615	COG0243	molybdopterin cofactor binding
DLD53_RS17620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DLD53_RS17625	COG3339	Conserved Protein
DLD53_RS17635	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DLD53_RS17650	COG1113	amino acid transport
DLD53_RS17660	COG0019	diaminopimelate decarboxylase activity
DLD53_RS17670	COG1280	lysine exporter protein (LysE YggA)
DLD53_RS17675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DLD53_RS17705	COG0463	Glycosyl transferase, family 2
DLD53_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLD53_RS17755	COG4591	ABC-type transport system involved in lipoprotein release permease component
DLD53_RS17760	COG1136	(ABC) transporter
DLD53_RS17765	COG2333	competence protein COMEC
DLD53_RS17765	COG0658	competence protein
DLD53_RS17775	COG0616	signal peptide processing
DLD53_RS17775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLD53_RS17780	COG0596	Alpha beta hydrolase
DLD53_RS17785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DLD53_RS17795	COG0628	permease
DLD53_RS17830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLD53_RS17850	COG0823	Involved in the tonB-independent uptake of proteins
DLD53_RS17870	COG0824	Thioesterase
DLD53_RS17875	COG1473	amidohydrolase
DLD53_RS17895	COG0047	phosphoribosylformylglycinamidine synthase activity
DLD53_RS17895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLD53_RS17900	COG2814	Major facilitator Superfamily
DLD53_RS17910	COG1024	Enoyl-CoA hydratase
DLD53_RS17915	COG1051	belongs to the nudix hydrolase family
DLD53_RS17915	COG1056	cytidyltransferase-related domain
DLD53_RS17925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DLD53_RS17940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DLD53_RS17955	COG4625	pathogenesis
DLD53_RS17960	COG0583	DNA-binding transcription factor activity
DLD53_RS17965	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DLD53_RS17970	COG4208	sulfate ABC transporter
DLD53_RS17975	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DLD53_RS17985	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DLD53_RS17990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DLD53_RS17995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DLD53_RS18015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLD53_RS18030	COG0681	Belongs to the peptidase S26 family
DLD53_RS18045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DLD53_RS18055	COG1381	Involved in DNA repair and RecF pathway recombination
DLD53_RS18060	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DLD53_RS18070	COG4221	oxidoreductase activity
DLD53_RS18100	COG0436	Aminotransferase
DLD53_RS18120	COG0556	nucleotide-excision repair
DLD53_RS18175	COG2070	2-Nitropropane dioxygenase
DLD53_RS18205	COG1215	transferase activity, transferring glycosyl groups
DLD53_RS18220	COG0415	Belongs to the DNA photolyase family
DLD53_RS18230	COG1252	NADH dehydrogenase
DLD53_RS18235	COG1686	Belongs to the peptidase S11 family
DLD53_RS18250	COG1187	pseudouridine synthase activity
DLD53_RS18275	COG0477	Major facilitator Superfamily
DLD53_RS18280	COG0583	DNA-binding transcription factor activity
DLD53_RS18285	COG1823	symporter activity
DLD53_RS18295	COG0612	Peptidase, M16
DLD53_RS18320	COG0352	thiamine-phosphate diphosphorylase activity
DLD53_RS18355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLD53_RS18370	COG1309	transcriptional regulator
DLD53_RS18380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLD53_RS18385	COG0076	glutamate decarboxylase activity
DLD53_RS18395	COG1522	sequence-specific DNA binding
DLD53_RS18400	COG3961	Belongs to the TPP enzyme family
DLD53_RS18405	COG1113	amino acid transport
DLD53_RS18410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DLD53_RS18415	COG0573	inorganic phosphate transmembrane transporter activity
DLD53_RS18425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DLD53_RS18430	COG0616	signal peptide processing
DLD53_RS18465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DLD53_RS18470	COG1686	Belongs to the peptidase S11 family
DLD53_RS18495	COG0583	DNA-binding transcription factor activity
DLD53_RS18500	COG1067	ATP-dependent peptidase activity
DLD53_RS18545	COG1966	Carbon starvation protein
DLD53_RS18550	COG2879	small protein
DLD53_RS18920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLD53_RS18950	COG2508	Transcriptional regulator
DLD53_RS18950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DLD53_RS18970	COG1113	amino acid transport
DLD53_RS18990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLD53_RS18995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLD53_RS19005	COG1012	belongs to the aldehyde dehydrogenase family
DLD53_RS19010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLD53_RS19015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLD53_RS19015	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DLD53_RS19040	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS19060	COG2814	Major facilitator Superfamily
DLD53_RS19065	COG4948	Mandelate Racemase Muconate Lactonizing
DLD53_RS19075	COG1309	transcriptional regulator
DLD53_RS19095	COG1741	Belongs to the pirin family
DLD53_RS19105	COG2964	Protein conserved in bacteria
DLD53_RS19120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLD53_RS19125	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLD53_RS19130	COG4605	iron ion homeostasis
DLD53_RS19135	COG4604	ABC transporter, ATP-binding protein
DLD53_RS19140	COG4607	ABC-type enterochelin transport system periplasmic component
DLD53_RS19145	COG4774	siderophore transport
DLD53_RS19155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLD53_RS19160	COG1021	2,3-dihydroxybenzoate-AMP ligase
DLD53_RS19165	COG3433	isochorismatase activity
DLD53_RS19165	COG1535	isochorismatase
DLD53_RS19180	COG1132	(ABC) transporter
DLD53_RS19185	COG1132	(ABC) transporter
DLD53_RS19190	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DLD53_RS19200	COG1169	isochorismate synthase
DLD53_RS19215	COG3739	integral membrane protein
DLD53_RS19240	COG0302	gtp cyclohydrolase
DLD53_RS19250	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLD53_RS19280	COG0308	aminopeptidase N
DLD53_RS19285	COG0512	Glutamine amidotransferase of anthranilate synthase
DLD53_RS19365	COG3620	sequence-specific DNA binding
DLD53_RS19530	COG0358	DNA primase activity
DLD53_RS19570	COG0194	GDP metabolic process
DLD53_RS19595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DLD53_RS19650	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DLD53_RS19695	COG0419	ATPase involved in DNA repair
DLD53_RS19725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DLD53_RS19725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLD53_RS19730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLD53_RS19755	COG0756	dUTP diphosphatase activity
DLD53_RS20000	COG1475	DNA binding
DLD53_RS20005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLD53_RS20115	COG0791	NLP P60 protein
DLD53_RS20175	COG1525	nuclease
DLD53_RS20240	COG1475	DNA binding
DLD53_RS20260	COG3853	Toxic anion resistance protein (TelA)
DLD53_RS20275	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS20285	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS20370	COG0484	heat shock protein binding
DLD53_RS20425	COG2826	transposase and inactivated derivatives, IS30 family
DLD53_RS20465	COG0741	lytic transglycosylase activity
DLD53_RS20500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLD53_RS20580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII