locus-tag	class	description
GWK28_RS00010	COG0592	DNA-directed DNA polymerase activity
GWK28_RS00020	COG0187	DNA topoisomerase II activity
GWK28_RS00030	COG0586	Pfam SNARE associated Golgi protein
GWK28_RS00035	COG0488	(ABC) transporter
GWK28_RS00060	COG0596	Alpha beta hydrolase
GWK28_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GWK28_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GWK28_RS00110	COG0733	neurotransmitter:sodium symporter activity
GWK28_RS00145	COG0583	DNA-binding transcription factor activity
GWK28_RS00150	COG2233	PERMEase
GWK28_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_RS00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_RS00200	COG2814	Major facilitator Superfamily
GWK28_RS00205	COG0656	L-ascorbic acid biosynthetic process
GWK28_RS00210	COG0583	DNA-binding transcription factor activity
GWK28_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS00230	COG1064	alcohol dehydrogenase
GWK28_RS00235	COG2818	Glycosylase
GWK28_RS00250	COG1194	a g-specific adenine glycosylase
GWK28_RS00270	COG2983	Belongs to the UPF0260 family
GWK28_RS00275	COG2133	pyrroloquinoline quinone binding
GWK28_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GWK28_RS00285	COG2116	formate transmembrane transporter activity
GWK28_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_RS00310	COG1335	isochorismatase
GWK28_RS00315	COG0385	Bile acid
GWK28_RS00320	COG0534	Mate efflux family protein
GWK28_RS00325	COG1683	Conserved Protein
GWK28_RS00345	COG0625	glutathione transferase activity
GWK28_RS00355	COG1113	amino acid transport
GWK28_RS00365	COG0523	cobalamin synthesis protein
GWK28_RS00375	COG2188	Transcriptional regulator
GWK28_RS00405	COG0010	Belongs to the arginase family
GWK28_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWK28_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GWK28_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GWK28_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GWK28_RS00530	COG0534	Mate efflux family protein
GWK28_RS00535	COG0436	Aminotransferase
GWK28_RS00540	COG2733	membrane
GWK28_RS00555	COG2918	glutathione biosynthetic process
GWK28_RS00570	COG3409	Peptidoglycan-binding domain 1 protein
GWK28_RS00570	COG1388	LysM domain
GWK28_RS00570	COG5632	N-Acetylmuramoyl-L-alanine amidase
GWK28_RS00620	COG3150	esterase
GWK28_RS00630	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GWK28_RS00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_RS00655	COG2233	PERMEase
GWK28_RS00660	COG2351	hydroxyisourate hydrolase activity
GWK28_RS00690	COG3328	transposase activity
GWK28_RS00700	COG3706	GGDEF domain
GWK28_RS00715	COG1393	Belongs to the ArsC family
GWK28_RS00720	COG0708	Exodeoxyribonuclease III
GWK28_RS00750	COG0189	ligase activity
GWK28_RS00770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GWK28_RS00780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GWK28_RS00795	COG4942	peptidase
GWK28_RS00805	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK28_RS00815	COG2119	membrane
GWK28_RS00820	COG4774	siderophore transport
GWK28_RS00825	COG0426	domain, Protein
GWK28_RS00825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS00850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GWK28_RS00870	COG1902	pentaerythritol trinitrate reductase activity
GWK28_RS00875	COG1519	Transferase
GWK28_RS00880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK28_RS00885	COG0668	transmembrane transport
GWK28_RS00895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_RS00900	COG1335	isochorismatase
GWK28_RS00905	COG1522	sequence-specific DNA binding
GWK28_RS00930	COG2198	Histidine kinase
GWK28_RS00930	COG0784	Response regulator, receiver
GWK28_RS00930	COG2205	protein histidine kinase activity
GWK28_RS00935	COG3162	membrane
GWK28_RS00940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK28_RS00950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_RS00965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GWK28_RS00970	COG1309	transcriptional regulator
GWK28_RS00990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK28_RS00990	COG0351	phosphomethylpyrimidine kinase
GWK28_RS00990	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_RS01000	COG2814	Major facilitator Superfamily
GWK28_RS01015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWK28_RS01025	COG1113	amino acid transport
GWK28_RS01035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK28_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS01050	COG1335	isochorismatase
GWK28_RS01080	COG2814	Major facilitator Superfamily
GWK28_RS01085	COG0583	DNA-binding transcription factor activity
GWK28_RS01105	COG0667	Aldo Keto reductase
GWK28_RS01145	COG1733	regulation of RNA biosynthetic process
GWK28_RS01150	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_RS01215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GWK28_RS01255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GWK28_RS01285	COG0427	acetyl-CoA hydrolase
GWK28_RS01310	COG0659	secondary active sulfate transmembrane transporter activity
GWK28_RS01315	COG4221	oxidoreductase activity
GWK28_RS01320	COG2873	o-acetylhomoserine
GWK28_RS01325	COG0488	(ABC) transporter
GWK28_RS01390	COG0833	amino acid
GWK28_RS01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GWK28_RS01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GWK28_RS01455	COG2226	methyltransferase
GWK28_RS01505	COG0070	glutamate synthase
GWK28_RS01505	COG0069	glutamate synthase activity
GWK28_RS01505	COG0067	glutamate synthase
GWK28_RS01510	COG0493	'glutamate synthase
GWK28_RS01520	COG1704	LemA family
GWK28_RS01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GWK28_RS01535	COG4969	Belongs to the N-Me-Phe pilin family
GWK28_RS01545	COG3307	-O-antigen
GWK28_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK28_RS01580	COG0194	GDP metabolic process
GWK28_RS01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GWK28_RS01650	COG5380	lipid catabolic process
GWK28_RS01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GWK28_RS01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GWK28_RS01685	COG0277	FAD linked oxidase domain protein
GWK28_RS01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GWK28_RS01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_RS01715	COG1289	transmembrane transporter activity
GWK28_RS01725	COG0628	permease
GWK28_RS01730	COG1192	Involved in chromosome partitioning
GWK28_RS01760	COG0833	amino acid
GWK28_RS01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK28_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK28_RS01780	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS01820	COG0583	DNA-binding transcription factor activity
GWK28_RS01840	COG1106	Psort location Cytoplasmic, score
GWK28_RS01875	COG0517	IMP dehydrogenase activity
GWK28_RS01880	COG1983	PspC domain protein
GWK28_RS01890	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS01905	COG0408	coproporphyrinogen oxidase activity
GWK28_RS01925	COG0513	Belongs to the DEAD box helicase family
GWK28_RS01935	COG1127	ABC transporter
GWK28_RS01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GWK28_RS01950	COG2854	intermembrane phospholipid transfer
GWK28_RS01960	COG0598	Magnesium transport protein CorA
GWK28_RS01970	COG0494	nUDIX hydrolase
GWK28_RS01975	COG1040	competence protein
GWK28_RS01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GWK28_RS02000	COG1946	Acyl-CoA thioesterase
GWK28_RS02005	COG1301	dicarboxylic acid transport
GWK28_RS02020	COG1959	2 iron, 2 sulfur cluster binding
GWK28_RS02025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_RS02025	COG1017	nitric oxide dioxygenase activity
GWK28_RS02035	COG0433	COG0433 Predicted ATPase
GWK28_RS02040	COG0626	cystathionine gamma-synthase activity
GWK28_RS02195	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS02200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GWK28_RS02230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GWK28_RS02235	COG0339	signal peptide processing
GWK28_RS02240	COG0557	exoribonuclease II activity
GWK28_RS02285	COG0179	Fumarylacetoacetate (FAA) hydrolase
GWK28_RS02290	COG2169	Transcriptional regulator
GWK28_RS02295	COG0697	spore germination
GWK28_RS02300	COG1295	ribonuclease BN
GWK28_RS02335	COG1702	phosphate starvation-inducible protein PhoH
GWK28_RS02345	COG1196	nuclear chromosome segregation
GWK28_RS02345	COG0741	lytic transglycosylase activity
GWK28_RS02345	COG0739	heme binding
GWK28_RS02375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GWK28_RS02380	COG1183	phosphatidylcholine synthase activity
GWK28_RS02425	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS02430	COG1309	transcriptional regulator
GWK28_RS02445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK28_RS02450	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS02470	COG2969	positive regulation of protein catabolic process
GWK28_RS02480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GWK28_RS02495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GWK28_RS02500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GWK28_RS02520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GWK28_RS02530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK28_RS02535	COG1408	metallophosphoesterase
GWK28_RS02545	COG2199	diguanylate cyclase activity
GWK28_RS02605	COG1607	acyl-coa hydrolase
GWK28_RS02635	COG2350	Protein conserved in bacteria
GWK28_RS02645	COG0613	PHP domain protein
GWK28_RS02650	COG3781	membrane
GWK28_RS02660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GWK28_RS02665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GWK28_RS02675	COG1862	Preprotein translocase
GWK28_RS02705	COG2205	protein histidine kinase activity
GWK28_RS02710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GWK28_RS02725	COG0726	polysaccharide deacetylase
GWK28_RS02730	COG0438	transferase activity, transferring glycosyl groups
GWK28_RS02750	COG0438	transferase activity, transferring glycosyl groups
GWK28_RS02755	COG1215	transferase activity, transferring glycosyl groups
GWK28_RS02760	COG0438	transferase activity, transferring glycosyl groups
GWK28_RS02805	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS02810	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS02820	COG2205	protein histidine kinase activity
GWK28_RS02825	COG0745	RESPONSE REGULATOR receiver
GWK28_RS02830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GWK28_RS02850	COG2096	Adenosyltransferase
GWK28_RS02900	COG0285	dihydrofolate synthase activity
GWK28_RS02920	COG0450	alkyl hydroperoxide reductase
GWK28_RS02935	COG0477	Major facilitator Superfamily
GWK28_RS02940	COG1272	protein, Hemolysin III
GWK28_RS02970	COG0183	Belongs to the thiolase family
GWK28_RS02975	COG2207	Transcriptional regulator
GWK28_RS02995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_RS03015	COG0183	Belongs to the thiolase family
GWK28_RS03025	COG2885	chlorophyll binding
GWK28_RS03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GWK28_RS03035	COG1690	Belongs to the RtcB family
GWK28_RS03040	COG0833	amino acid
GWK28_RS03050	COG2233	PERMEase
GWK28_RS03055	COG1217	gtp-binding protein TYPA
GWK28_RS03080	COG2094	Belongs to the DNA glycosylase MPG family
GWK28_RS03085	COG4772	TonB-dependent receptor
GWK28_RS03090	COG1902	pentaerythritol trinitrate reductase activity
GWK28_RS03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_RS03110	COG0354	folic acid binding
GWK28_RS03120	COG3189	MarR family transcriptional regulator
GWK28_RS03125	COG2824	Alkylphosphonate utilization operon protein PhnA
GWK28_RS03170	COG0840	transmembrane signaling receptor activity
GWK28_RS03190	COG5510	response to toxic substance
GWK28_RS03200	COG2832	Protein of unknown function (DUF454)
GWK28_RS03205	COG1376	ErfK ybiS ycfS ynhG family protein
GWK28_RS03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GWK28_RS03255	COG1289	transmembrane transporter activity
GWK28_RS03260	COG2814	Major facilitator Superfamily
GWK28_RS03280	COG1115	amino acid carrier protein
GWK28_RS03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK28_RS03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK28_RS03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GWK28_RS03300	COG3590	peptidase
GWK28_RS03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK28_RS03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GWK28_RS03340	COG1077	Cell shape determining protein MreB Mrl
GWK28_RS03345	COG1792	Involved in formation and maintenance of cell shape
GWK28_RS03350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GWK28_RS03355	COG0424	maF-like protein
GWK28_RS03360	COG1530	ribonuclease E activity
GWK28_RS03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_RS03380	COG0560	Phosphoserine phosphatase
GWK28_RS03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_RS03415	COG2207	Transcriptional regulator
GWK28_RS03465	COG3328	transposase activity
GWK28_RS03480	COG0305	Participates in initiation and elongation during chromosome replication
GWK28_RS03525	COG0582	viral genome integration into host DNA
GWK28_RS03535	COG1113	amino acid transport
GWK28_RS03540	COG2828	Protein conserved in bacteria
GWK28_RS03545	COG0142	geranyltranstransferase activity
GWK28_RS03550	COG2315	Protein conserved in bacteria
GWK28_RS03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
GWK28_RS03585	COG2194	sulfuric ester hydrolase activity
GWK28_RS03590	COG0745	RESPONSE REGULATOR receiver
GWK28_RS03595	COG0642	Histidine kinase
GWK28_RS03605	COG0004	ammonium transporteR
GWK28_RS03615	COG0525	valine-tRNA ligase activity
GWK28_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS03635	COG0393	Putative heavy-metal-binding
GWK28_RS03640	COG0393	Putative heavy-metal-binding
GWK28_RS03645	COG1538	Outer membrane efflux protein
GWK28_RS03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_RS03660	COG0671	phosphoesterase, PA-phosphatase related
GWK28_RS03690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GWK28_RS03705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GWK28_RS03705	COG1648	precorrin-2 dehydrogenase activity
GWK28_RS03710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GWK28_RS03715	COG1733	regulation of RNA biosynthetic process
GWK28_RS03725	COG0531	amino acid
GWK28_RS03740	COG0321	lipoyl(octanoyl) transferase activity
GWK28_RS03745	COG2921	Belongs to the UPF0250 family
GWK28_RS03780	COG2009	succinate dehydrogenase
GWK28_RS03785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GWK28_RS03790	COG1053	succinate dehydrogenase
GWK28_RS03795	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GWK28_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_RS03840	COG2354	Protein conserved in bacteria
GWK28_RS03845	COG2321	neutral zinc metallopeptidase
GWK28_RS03865	COG2843	Capsule synthesis protein
GWK28_RS03880	COG0589	response to stress
GWK28_RS03900	COG0505	Belongs to the CarA family
GWK28_RS03925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK28_RS03930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GWK28_RS03980	COG0477	Major facilitator Superfamily
GWK28_RS03985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GWK28_RS04000	COG1597	lipid kinase activity
GWK28_RS04005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK28_RS04025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_RS04030	COG0584	glycerophosphoryl diester phosphodiesterase
GWK28_RS04050	COG0741	lytic transglycosylase activity
GWK28_RS04070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK28_RS04095	COG0071	Belongs to the small heat shock protein (HSP20) family
GWK28_RS04100	COG0542	response to heat
GWK28_RS04145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_RS04185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GWK28_RS04225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_RS04230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK28_RS04255	COG0778	Nitroreductase
GWK28_RS04260	COG0300	oxidoreductase activity
GWK28_RS04270	COG1929	Belongs to the glycerate kinase type-1 family
GWK28_RS04275	COG0243	molybdopterin cofactor binding
GWK28_RS04280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GWK28_RS04285	COG3339	Conserved Protein
GWK28_RS04310	COG1113	amino acid transport
GWK28_RS04320	COG0019	diaminopimelate decarboxylase activity
GWK28_RS04330	COG1280	lysine exporter protein (LysE YggA)
GWK28_RS04335	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWK28_RS04365	COG0463	Glycosyl transferase, family 2
GWK28_RS04385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_RS04420	COG4591	ABC-type transport system involved in lipoprotein release permease component
GWK28_RS04425	COG1136	(ABC) transporter
GWK28_RS04430	COG0658	competence protein
GWK28_RS04430	COG2333	competence protein COMEC
GWK28_RS04440	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GWK28_RS04440	COG0616	signal peptide processing
GWK28_RS04445	COG0596	Alpha beta hydrolase
GWK28_RS04450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GWK28_RS04460	COG0628	permease
GWK28_RS04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK28_RS04515	COG0823	Involved in the tonB-independent uptake of proteins
GWK28_RS04535	COG0824	Thioesterase
GWK28_RS04540	COG1473	amidohydrolase
GWK28_RS04560	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GWK28_RS04560	COG0047	phosphoribosylformylglycinamidine synthase activity
GWK28_RS04565	COG2814	Major facilitator Superfamily
GWK28_RS04575	COG1024	Enoyl-CoA hydratase
GWK28_RS04580	COG1056	cytidyltransferase-related domain
GWK28_RS04580	COG1051	belongs to the nudix hydrolase family
GWK28_RS04590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GWK28_RS04605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GWK28_RS04620	COG4625	pathogenesis
GWK28_RS04625	COG0583	DNA-binding transcription factor activity
GWK28_RS04630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GWK28_RS04635	COG4208	sulfate ABC transporter
GWK28_RS04640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GWK28_RS04650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GWK28_RS04655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GWK28_RS04660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GWK28_RS04680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_RS04695	COG0681	Belongs to the peptidase S26 family
GWK28_RS04710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GWK28_RS04720	COG1381	Involved in DNA repair and RecF pathway recombination
GWK28_RS04725	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GWK28_RS04735	COG4221	oxidoreductase activity
GWK28_RS04765	COG0436	Aminotransferase
GWK28_RS04785	COG0556	nucleotide-excision repair
GWK28_RS04840	COG2070	2-Nitropropane dioxygenase
GWK28_RS04870	COG1215	transferase activity, transferring glycosyl groups
GWK28_RS04885	COG0415	Belongs to the DNA photolyase family
GWK28_RS04895	COG1252	NADH dehydrogenase
GWK28_RS04900	COG1686	Belongs to the peptidase S11 family
GWK28_RS04915	COG1187	pseudouridine synthase activity
GWK28_RS04940	COG0477	Major facilitator Superfamily
GWK28_RS04945	COG0583	DNA-binding transcription factor activity
GWK28_RS04950	COG1823	symporter activity
GWK28_RS04960	COG0612	Peptidase, M16
GWK28_RS04985	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_RS05020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_RS05035	COG1309	transcriptional regulator
GWK28_RS05045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GWK28_RS05050	COG0076	glutamate decarboxylase activity
GWK28_RS05060	COG1522	sequence-specific DNA binding
GWK28_RS05065	COG3961	Belongs to the TPP enzyme family
GWK28_RS05070	COG1113	amino acid transport
GWK28_RS05075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GWK28_RS05080	COG0573	inorganic phosphate transmembrane transporter activity
GWK28_RS05090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GWK28_RS05095	COG0616	signal peptide processing
GWK28_RS05130	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GWK28_RS05135	COG1686	Belongs to the peptidase S11 family
GWK28_RS05160	COG0583	DNA-binding transcription factor activity
GWK28_RS05165	COG1067	ATP-dependent peptidase activity
GWK28_RS05170	COG2211	Major facilitator Superfamily
GWK28_RS05210	COG1966	Carbon starvation protein
GWK28_RS05215	COG2879	small protein
GWK28_RS05225	COG0653	protein targeting
GWK28_RS05235	COG1741	Belongs to the pirin family
GWK28_RS05245	COG2964	Protein conserved in bacteria
GWK28_RS05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_RS05265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK28_RS05270	COG4605	iron ion homeostasis
GWK28_RS05275	COG4604	ABC transporter, ATP-binding protein
GWK28_RS05280	COG4607	ABC-type enterochelin transport system periplasmic component
GWK28_RS05285	COG4774	siderophore transport
GWK28_RS05295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GWK28_RS05300	COG1021	2,3-dihydroxybenzoate-AMP ligase
GWK28_RS05305	COG1535	isochorismatase
GWK28_RS05305	COG3433	isochorismatase activity
GWK28_RS05320	COG1132	(ABC) transporter
GWK28_RS05325	COG1132	(ABC) transporter
GWK28_RS05330	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GWK28_RS05335	COG2977	Belongs to the P-Pant transferase superfamily
GWK28_RS05340	COG1169	isochorismate synthase
GWK28_RS05355	COG3739	integral membrane protein
GWK28_RS05375	COG0302	gtp cyclohydrolase
GWK28_RS05385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GWK28_RS05395	COG2840	Smr protein MutS2
GWK28_RS05415	COG0308	aminopeptidase N
GWK28_RS05420	COG0512	Glutamine amidotransferase of anthranilate synthase
GWK28_RS05435	COG0174	glutamine synthetase
GWK28_RS05445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GWK28_RS05480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GWK28_RS05485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GWK28_RS05490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GWK28_RS05510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GWK28_RS05515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GWK28_RS05520	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GWK28_RS05535	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS05540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWK28_RS05545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_RS05555	COG2223	nitrite transmembrane transporter activity
GWK28_RS05565	COG0024	Methionine aminopeptidase
GWK28_RS05570	COG0052	Belongs to the universal ribosomal protein uS2 family
GWK28_RS05585	COG2207	Transcriptional regulator
GWK28_RS05610	COG2951	lytic endotransglycosylase activity
GWK28_RS05615	COG0772	Belongs to the SEDS family
GWK28_RS05630	COG0842	Transport permease protein
GWK28_RS05635	COG1131	(ABC) transporter
GWK28_RS05680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_RS05695	COG4215	(ABC) transporter
GWK28_RS05700	COG4160	amino acid transport
GWK28_RS05705	COG4598	ABC transporter
GWK28_RS05715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWK28_RS05720	COG0826	peptidase U32
GWK28_RS05725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS05750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GWK28_RS05765	COG0642	Histidine kinase
GWK28_RS05775	COG0494	nUDIX hydrolase
GWK28_RS05785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GWK28_RS05790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GWK28_RS05795	COG3139	Protein of unknown function (DUF1315)
GWK28_RS05800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GWK28_RS05805	COG1301	dicarboxylic acid transport
GWK28_RS05815	COG2819	hydrolase of the alpha beta superfamily
GWK28_RS05825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GWK28_RS05835	COG2195	Cleaves the N-terminal amino acid of tripeptides
GWK28_RS05855	COG1690	Belongs to the RtcB family
GWK28_RS05860	COG1234	tRNA 3'-trailer cleavage
GWK28_RS05865	COG4650	regulator
GWK28_RS05895	COG2363	Small membrane protein
GWK28_RS05915	COG0513	Belongs to the DEAD box helicase family
GWK28_RS05925	COG0778	Nitroreductase
GWK28_RS05955	COG1286	toxin biosynthetic process
GWK28_RS05980	COG4783	chaperone-mediated protein folding
GWK28_RS05985	COG1610	YqeY-like protein
GWK28_RS06015	COG0515	serine threonine protein kinase
GWK28_RS06015	COG2815	serine threonine protein kinase
GWK28_RS06040	COG2831	hemolysin activation secretion protein
GWK28_RS06050	COG3328	transposase activity
GWK28_RS06160	COG3111	PFAM Bacterial OB fold (BOF) protein
GWK28_RS06195	COG3243	poly(R)-hydroxyalkanoic acid synthase
GWK28_RS06200	COG0786	glutamate:sodium symporter activity
GWK28_RS06210	COG2186	Transcriptional regulator
GWK28_RS06260	COG3328	transposase activity
GWK28_RS06265	COG0477	Major facilitator Superfamily
GWK28_RS06290	COG2995	paraquat-inducible protein a
GWK28_RS06295	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GWK28_RS06295	COG3008	intermembrane lipid transfer
GWK28_RS06305	COG2351	hydroxyisourate hydrolase activity
GWK28_RS06345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWK28_RS06355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GWK28_RS06360	COG0642	Histidine kinase
GWK28_RS06365	COG0745	RESPONSE REGULATOR receiver
GWK28_RS06390	COG1794	racemase activity, acting on amino acids and derivatives
GWK28_RS06420	COG1301	dicarboxylic acid transport
GWK28_RS06430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_RS06435	COG2011	ABC-type metal ion transport system permease component
GWK28_RS06440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_RS06445	COG1464	Belongs to the NlpA lipoprotein family
GWK28_RS06450	COG0151	Belongs to the GarS family
GWK28_RS06455	COG0138	bifunctional purine biosynthesis protein purh
GWK28_RS06460	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GWK28_RS06490	COG2308	Evidence 4 Homologs of previously reported genes of
GWK28_RS06500	COG1305	Transglutaminase-like
GWK28_RS06510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GWK28_RS06515	COG0305	Participates in initiation and elongation during chromosome replication
GWK28_RS06540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GWK28_RS06550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GWK28_RS06555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GWK28_RS06580	COG1649	PFAM Uncharacterised BCR, COG1649
GWK28_RS06580	COG0726	polysaccharide deacetylase
GWK28_RS06585	COG1215	transferase activity, transferring glycosyl groups
GWK28_RS06590	COG3658	cytochrome
GWK28_RS06600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_RS06615	COG0583	DNA-binding transcription factor activity
GWK28_RS06645	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS06650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_RS06655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS06680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GWK28_RS06685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GWK28_RS06695	COG2205	protein histidine kinase activity
GWK28_RS06700	COG0745	RESPONSE REGULATOR receiver
GWK28_RS06705	COG0174	glutamine synthetase
GWK28_RS06725	COG0729	surface antigen
GWK28_RS06750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK28_RS06755	COG2814	Major facilitator Superfamily
GWK28_RS06770	COG0583	DNA-binding transcription factor activity
GWK28_RS06785	COG1187	pseudouridine synthase activity
GWK28_RS06805	COG0802	atpase or kinase
GWK28_RS06810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GWK28_RS06820	COG1923	regulation of RNA biosynthetic process
GWK28_RS06825	COG0697	spore germination
GWK28_RS06850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK28_RS06855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK28_RS06855	COG0519	Catalyzes the synthesis of GMP from XMP
GWK28_RS06860	COG4302	ethanolamine ammonia-lyase activity
GWK28_RS06865	COG4303	Ethanolamine ammonia lyase large subunit
GWK28_RS06870	COG0531	amino acid
GWK28_RS06890	COG1454	alcohol dehydrogenase
GWK28_RS06895	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_RS06905	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GWK28_RS06925	COG0308	aminopeptidase N
GWK28_RS06945	COG1605	Chorismate mutase
GWK28_RS06960	COG1309	transcriptional regulator
GWK28_RS06970	COG0668	transmembrane transport
GWK28_RS07000	COG4773	Receptor
GWK28_RS07020	COG0488	(ABC) transporter
GWK28_RS07025	COG0589	response to stress
GWK28_RS07055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GWK28_RS07065	COG3135	benzoate transporter
GWK28_RS07070	COG1522	sequence-specific DNA binding
GWK28_RS07080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GWK28_RS07085	COG0583	DNA-binding transcription factor activity
GWK28_RS07095	COG0183	Belongs to the thiolase family
GWK28_RS07105	COG2030	dehydratase
GWK28_RS07110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK28_RS07135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GWK28_RS07150	COG0824	Thioesterase
GWK28_RS07155	COG1454	alcohol dehydrogenase
GWK28_RS07165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GWK28_RS07185	COG0069	glutamate synthase activity
GWK28_RS07215	COG1484	DNA-dependent DNA replication
GWK28_RS07430	COG2814	Major facilitator Superfamily
GWK28_RS07445	COG0511	ligase activity, forming carbon-carbon bonds
GWK28_RS07460	COG3328	transposase activity
GWK28_RS07490	COG1196	nuclear chromosome segregation
GWK28_RS07505	COG1116	anion transmembrane transporter activity
GWK28_RS07505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_RS07510	COG0745	RESPONSE REGULATOR receiver
GWK28_RS07520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_RS07520	COG2146	nitrite reductase [NAD(P)H] activity
GWK28_RS07525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_RS07530	COG0243	molybdopterin cofactor binding
GWK28_RS07540	COG0243	molybdopterin cofactor binding
GWK28_RS07545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GWK28_RS07560	COG0521	Mo-molybdopterin cofactor biosynthetic process
GWK28_RS07560	COG0315	cyclic pyranopterin monophosphate synthase activity
GWK28_RS07575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS07580	COG0697	spore germination
GWK28_RS07600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GWK28_RS07605	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK28_RS07660	COG2204	response regulator
GWK28_RS07665	COG3852	Histidine kinase
GWK28_RS07690	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GWK28_RS07695	COG0575	Belongs to the CDS family
GWK28_RS07730	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWK28_RS07745	COG2137	regulation of response to DNA damage stimulus
GWK28_RS07755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GWK28_RS07760	COG1011	Hydrolase
GWK28_RS07785	COG1522	sequence-specific DNA binding
GWK28_RS07795	COG1113	amino acid transport
GWK28_RS07810	COG0659	secondary active sulfate transmembrane transporter activity
GWK28_RS07815	COG2135	peptidase activity
GWK28_RS07830	COG5001	Diguanylate cyclase
GWK28_RS07830	COG3300	MHYT domain
GWK28_RS07845	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GWK28_RS07845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK28_RS07845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GWK28_RS07850	COG1105	Belongs to the carbohydrate kinase PfkB family
GWK28_RS07855	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GWK28_RS07855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK28_RS07885	COG0024	Methionine aminopeptidase
GWK28_RS07890	COG0583	DNA-binding transcription factor activity
GWK28_RS07900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GWK28_RS07905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GWK28_RS07910	COG0516	GMP reductase activity
GWK28_RS07910	COG0517	IMP dehydrogenase activity
GWK28_RS07935	COG0552	protein localization to endoplasmic reticulum
GWK28_RS07945	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GWK28_RS07955	COG4890	Cyd operon protein YbgT
GWK28_RS07960	COG1294	oxidase, subunit
GWK28_RS07975	COG1585	Membrane protein implicated in regulation of membrane protease activity
GWK28_RS07985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GWK28_RS07990	COG4774	siderophore transport
GWK28_RS08005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GWK28_RS08010	COG0569	domain protein
GWK28_RS08015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GWK28_RS08045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GWK28_RS08050	COG0542	response to heat
GWK28_RS08075	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK28_RS08075	COG1902	pentaerythritol trinitrate reductase activity
GWK28_RS08120	COG2323	membrane
GWK28_RS08125	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GWK28_RS08135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_RS08140	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_RS08145	COG0183	Belongs to the thiolase family
GWK28_RS08150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GWK28_RS08155	COG0596	Alpha beta hydrolase
GWK28_RS08160	COG2271	Major facilitator Superfamily
GWK28_RS08165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK28_RS08170	COG3485	protocatechuate 3,4-dioxygenase
GWK28_RS08175	COG3485	protocatechuate 3,4-dioxygenase
GWK28_RS08180	COG0710	3-dehydroquinate dehydratase activity
GWK28_RS08185	COG3420	alginic acid biosynthetic process
GWK28_RS08190	COG3659	wide pore channel activity
GWK28_RS08205	COG2391	methyltransferase activity
GWK28_RS08220	COG1414	Transcriptional regulator
GWK28_RS08225	COG0583	DNA-binding transcription factor activity
GWK28_RS08230	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS08255	COG2814	Major facilitator Superfamily
GWK28_RS08265	COG0154	amidase activity
GWK28_RS08285	COG4638	Rieske (2fe-2S)
GWK28_RS08295	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS08305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS08315	COG3733	amine oxidase
GWK28_RS08325	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS08330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_RS08335	COG0183	Belongs to the thiolase family
GWK28_RS08340	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_RS08345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_RS08355	COG4829	muconolactone delta-isomerase
GWK28_RS08360	COG4948	Mandelate Racemase Muconate Lactonizing
GWK28_RS08365	COG0583	DNA-binding transcription factor activity
GWK28_RS08375	COG2186	Transcriptional regulator
GWK28_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS08420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GWK28_RS08430	COG0789	Transcriptional regulator
GWK28_RS08445	COG1309	transcriptional regulator
GWK28_RS08460	COG1309	transcriptional regulator
GWK28_RS08490	COG2188	Transcriptional regulator
GWK28_RS08505	COG0583	DNA-binding transcription factor activity
GWK28_RS08520	COG1566	PFAM secretion protein HlyD family protein
GWK28_RS08535	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS08540	COG0129	dihydroxy-acid dehydratase activity
GWK28_RS08550	COG0583	DNA-binding transcription factor activity
GWK28_RS08555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GWK28_RS08565	COG2084	Dehydrogenase
GWK28_RS08570	COG2207	Transcriptional regulator
GWK28_RS08585	COG1064	alcohol dehydrogenase
GWK28_RS08595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GWK28_RS08600	COG1120	ATPase activity
GWK28_RS08620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK28_RS08670	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GWK28_RS08725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_RS08780	COG0753	catalase activity
GWK28_RS08795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GWK28_RS08855	COG3433	isochorismatase activity
GWK28_RS08855	COG1535	isochorismatase
GWK28_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS08865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GWK28_RS08870	COG4149	molybdate abc transporter
GWK28_RS08875	COG0725	ABC transporter, periplasmic molybdate-binding protein
GWK28_RS08885	COG4638	Rieske (2fe-2S)
GWK28_RS08890	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWK28_RS08895	COG0543	2 iron, 2 sulfur cluster binding
GWK28_RS08895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_RS08910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS08935	COG2207	Transcriptional regulator
GWK28_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS08945	COG2610	gluconate transmembrane transporter activity
GWK28_RS08955	COG1309	transcriptional regulator
GWK28_RS08975	COG0583	DNA-binding transcription factor activity
GWK28_RS08990	COG2031	fatty acid transporter
GWK28_RS08995	COG0183	Belongs to the thiolase family
GWK28_RS09000	COG0583	DNA-binding transcription factor activity
GWK28_RS09005	COG0583	DNA-binding transcription factor activity
GWK28_RS09020	COG1027	Aspartate ammonia-lyase
GWK28_RS09050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_RS09055	COG4521	taurine ABC transporter
GWK28_RS09070	COG2188	Transcriptional regulator
GWK28_RS09080	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GWK28_RS09085	COG1733	regulation of RNA biosynthetic process
GWK28_RS09090	COG3708	Transcriptional regulator
GWK28_RS09090	COG2207	Transcriptional regulator
GWK28_RS09105	COG0730	response to heat
GWK28_RS09115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_RS09115	COG3453	Protein conserved in bacteria
GWK28_RS09125	COG3781	membrane
GWK28_RS09130	COG1063	alcohol dehydrogenase
GWK28_RS09140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GWK28_RS09145	COG0508	dehydrogenase complex catalyzes the overall conversion of
GWK28_RS09150	COG0022	dehydrogenase e1 component
GWK28_RS09155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GWK28_RS09160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GWK28_RS09190	COG0133	tryptophan synthase activity
GWK28_RS09200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GWK28_RS09235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GWK28_RS09260	COG2226	methyltransferase
GWK28_RS09315	COG0842	Transport permease protein
GWK28_RS09320	COG0842	Transport permease protein
GWK28_RS09325	COG1131	(ABC) transporter
GWK28_RS09340	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GWK28_RS09345	COG4773	Receptor
GWK28_RS09365	COG0730	response to heat
GWK28_RS09370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GWK28_RS09385	COG0406	alpha-ribazole phosphatase activity
GWK28_RS09390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GWK28_RS09405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK28_RS09435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK28_RS09445	COG4264	IucA IucC family
GWK28_RS09450	COG4264	IucA IucC family
GWK28_RS09455	COG2814	Major facilitator Superfamily
GWK28_RS09470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GWK28_RS09485	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS09490	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS09495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_RS09500	COG2207	Transcriptional regulator
GWK28_RS09505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK28_RS09510	COG0776	regulation of translation
GWK28_RS09535	COG0822	iron-sulfur transferase activity
GWK28_RS09540	COG0316	Belongs to the HesB IscA family
GWK28_RS09570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK28_RS09590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GWK28_RS09595	COG0702	epimerase
GWK28_RS09630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GWK28_RS09640	COG0339	signal peptide processing
GWK28_RS09690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GWK28_RS09695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GWK28_RS09725	COG0776	regulation of translation
GWK28_RS09790	COG0084	hydrolase, TatD family'
GWK28_RS09810	COG1663	tetraacyldisaccharide 4'-kinase activity
GWK28_RS09815	COG1132	(ABC) transporter
GWK28_RS09825	COG0811	peptide transport
GWK28_RS09830	COG1475	DNA binding
GWK28_RS09835	COG1192	Involved in chromosome partitioning
GWK28_RS09845	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GWK28_RS09860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GWK28_RS09865	COG0191	fructose-bisphosphate aldolase activity
GWK28_RS09885	COG0424	maF-like protein
GWK28_RS09890	COG2850	peptidyl-arginine hydroxylation
GWK28_RS09900	COG0640	Transcriptional regulator
GWK28_RS09910	COG3619	membrane
GWK28_RS09915	COG3122	Protein conserved in bacteria
GWK28_RS09920	COG1132	(ABC) transporter
GWK28_RS09940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GWK28_RS09945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GWK28_RS09955	COG0506	proline dehydrogenase activity
GWK28_RS09955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWK28_RS09955	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GWK28_RS09960	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GWK28_RS09975	COG3698	Phosphodiester glycosidase
GWK28_RS09985	COG2353	YceI-like domain
GWK28_RS09995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GWK28_RS10040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GWK28_RS10040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GWK28_RS10065	COG3539	Fimbrial protein
GWK28_RS10070	COG3121	Chaperone
GWK28_RS10105	COG0697	spore germination
GWK28_RS10120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK28_RS10130	COG0583	DNA-binding transcription factor activity
GWK28_RS10150	COG1309	transcriptional regulator
GWK28_RS10165	COG1522	sequence-specific DNA binding
GWK28_RS10175	COG1126	abc transporter atp-binding protein
GWK28_RS10180	COG0765	amino acid transport
GWK28_RS10185	COG0765	amino acid transport
GWK28_RS10215	COG1464	Belongs to the NlpA lipoprotein family
GWK28_RS10225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_RS10230	COG2011	ABC-type metal ion transport system permease component
GWK28_RS10235	COG0012	GTP binding
GWK28_RS10260	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GWK28_RS10300	COG0386	Belongs to the glutathione peroxidase family
GWK28_RS10310	COG0436	Aminotransferase
GWK28_RS10315	COG1301	dicarboxylic acid transport
GWK28_RS10350	COG3634	alkyl hydroperoxide reductase activity
GWK28_RS10365	COG0583	DNA-binding transcription factor activity
GWK28_RS10370	COG0798	PFAM Bile acid sodium symporter
GWK28_RS10375	COG0640	Transcriptional regulator
GWK28_RS10390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GWK28_RS10405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_RS10410	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GWK28_RS10415	COG4521	taurine ABC transporter
GWK28_RS10425	COG0477	Major facilitator Superfamily
GWK28_RS10445	COG1271	oxidase subunit
GWK28_RS10450	COG1294	oxidase, subunit
GWK28_RS10460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS10480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GWK28_RS10500	COG3052	prosthetic group binding
GWK28_RS10505	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GWK28_RS10515	COG0300	oxidoreductase activity
GWK28_RS10535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS10540	COG1346	cytolysis
GWK28_RS10550	COG0583	DNA-binding transcription factor activity
GWK28_RS10555	COG0625	glutathione transferase activity
GWK28_RS10560	COG0625	glutathione transferase activity
GWK28_RS10565	COG0583	DNA-binding transcription factor activity
GWK28_RS10580	COG1045	serine acetyltransferase
GWK28_RS10585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GWK28_RS10590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GWK28_RS10595	COG1280	lysine exporter protein (LysE YggA)
GWK28_RS10605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_RS10610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_RS10620	COG0765	amino acid transport
GWK28_RS10625	COG0765	amino acid transport
GWK28_RS10645	COG2205	protein histidine kinase activity
GWK28_RS10645	COG0784	Response regulator, receiver
GWK28_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS10735	COG0583	DNA-binding transcription factor activity
GWK28_RS10755	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_RS10760	COG1309	transcriptional regulator
GWK28_RS10765	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS10770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GWK28_RS10775	COG1024	Enoyl-CoA hydratase
GWK28_RS10780	COG4770	biotin carboxylase activity
GWK28_RS10790	COG0583	DNA-binding transcription factor activity
GWK28_RS10805	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS10815	COG2814	Major facilitator Superfamily
GWK28_RS10825	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_RS10830	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_RS10835	COG2814	Major facilitator Superfamily
GWK28_RS10840	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS10845	COG1024	Enoyl-CoA hydratase
GWK28_RS10850	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS10855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_RS10860	COG0183	Belongs to the thiolase family
GWK28_RS10870	COG2814	Major facilitator Superfamily
GWK28_RS10880	COG1024	Enoyl-CoA hydratase
GWK28_RS10890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_RS10895	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS10900	COG2814	Major facilitator Superfamily
GWK28_RS10905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GWK28_RS10910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GWK28_RS10925	COG3842	ATPase activity
GWK28_RS10930	COG1840	ABC-type Fe3 transport system, periplasmic component
GWK28_RS10940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_RS10945	COG1414	Transcriptional regulator
GWK28_RS10955	COG0583	DNA-binding transcription factor activity
GWK28_RS10960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GWK28_RS10965	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS10975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GWK28_RS10985	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS10990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_RS10995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS11000	COG2267	carboxylic ester hydrolase activity
GWK28_RS11020	COG3038	cytochrome b561
GWK28_RS11025	COG0753	catalase activity
GWK28_RS11030	COG2271	Major facilitator Superfamily
GWK28_RS11035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK28_RS11040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_RS11070	COG1278	Cold shock
GWK28_RS11120	COG2050	protein possibly involved in aromatic compounds catabolism
GWK28_RS11130	COG3327	negative regulation of DNA-templated transcription, initiation
GWK28_RS11135	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GWK28_RS11140	COG0183	Belongs to the thiolase family
GWK28_RS11145	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_RS11150	COG1024	Enoyl-CoA hydratase
GWK28_RS11155	COG1024	Enoyl-CoA hydratase
GWK28_RS11160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_RS11165	COG2151	metal-sulfur cluster biosynthetic enzyme
GWK28_RS11170	COG3396	Phenylacetate-CoA oxygenase
GWK28_RS11175	COG3460	Phenylacetate-CoA oxygenase
GWK28_RS11180	COG3396	Phenylacetate-CoA oxygenase
GWK28_RS11185	COG2030	dehydratase
GWK28_RS11185	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS11190	COG1760	l-serine dehydratase
GWK28_RS11195	COG0531	amino acid
GWK28_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS11225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GWK28_RS11245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_RS11290	COG1116	anion transmembrane transporter activity
GWK28_RS11295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GWK28_RS11305	COG0864	Transcriptional regulator
GWK28_RS11315	COG1733	regulation of RNA biosynthetic process
GWK28_RS11320	COG2249	NAD(P)H dehydrogenase (quinone) activity
GWK28_RS11325	COG0439	Biotin carboxylase
GWK28_RS11340	COG1063	alcohol dehydrogenase
GWK28_RS11350	COG1309	transcriptional regulator
GWK28_RS11360	COG0038	chloride channel
GWK28_RS11365	COG4770	biotin carboxylase activity
GWK28_RS11385	COG1914	H( )-stimulated, divalent metal cation uptake system
GWK28_RS11390	COG0583	DNA-binding transcription factor activity
GWK28_RS11425	COG3209	COG3209 Rhs family protein
GWK28_RS11455	COG1011	Hydrolase
GWK28_RS11475	COG1250	3-hydroxyacyl-CoA dehydrogenase
GWK28_RS11490	COG3328	transposase activity
GWK28_RS11510	COG2814	Major facilitator Superfamily
GWK28_RS11520	COG1560	Kdo2-lipid A biosynthetic process
GWK28_RS11530	COG5006	permease, DMT superfamily
GWK28_RS11535	COG1522	sequence-specific DNA binding
GWK28_RS11550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GWK28_RS11560	COG4122	O-methyltransferase activity
GWK28_RS11590	COG1538	Outer membrane efflux protein
GWK28_RS11595	COG1137	ATPase activity
GWK28_RS11600	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GWK28_RS11610	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GWK28_RS11615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GWK28_RS11615	COG0517	IMP dehydrogenase activity
GWK28_RS11655	COG2814	Major facilitator Superfamily
GWK28_RS11690	COG1278	Cold shock
GWK28_RS11695	COG1280	lysine exporter protein (LysE YggA)
GWK28_RS11725	COG1570	exodeoxyribonuclease VII activity
GWK28_RS11805	COG2871	sodium ion transport
GWK28_RS11815	COG0583	DNA-binding transcription factor activity
GWK28_RS11825	COG4638	Rieske (2fe-2S)
GWK28_RS11830	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GWK28_RS11835	COG0633	Ferredoxin
GWK28_RS11835	COG0543	2 iron, 2 sulfur cluster binding
GWK28_RS11840	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS11845	COG3135	benzoate transporter
GWK28_RS11850	COG2814	Major facilitator Superfamily
GWK28_RS11865	COG1643	Atp-dependent helicase
GWK28_RS11870	COG0450	alkyl hydroperoxide reductase
GWK28_RS11880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GWK28_RS11890	COG3634	alkyl hydroperoxide reductase activity
GWK28_RS11910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GWK28_RS11915	COG0625	glutathione transferase activity
GWK28_RS11925	COG2885	chlorophyll binding
GWK28_RS11960	COG0542	response to heat
GWK28_RS11975	COG1765	OsmC-like protein
GWK28_RS11985	COG0667	Aldo Keto reductase
GWK28_RS12000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GWK28_RS12010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GWK28_RS12020	COG0582	viral genome integration into host DNA
GWK28_RS12060	COG3179	chitinase
GWK28_RS12155	COG3566	protein conserved in bacteria
GWK28_RS12170	COG3567	Phage-associated protein, HI1409 family
GWK28_RS12175	COG5410	chromosome segregation
GWK28_RS12220	COG0527	aspartate kinase activity
GWK28_RS12230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GWK28_RS12240	COG3038	cytochrome b561
GWK28_RS12245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GWK28_RS12250	COG2252	PERMEase
GWK28_RS12260	COG2072	flavoprotein involved in K transport
GWK28_RS12275	COG1741	Belongs to the pirin family
GWK28_RS12280	COG1309	transcriptional regulator
GWK28_RS12290	COG0300	oxidoreductase activity
GWK28_RS12295	COG2072	flavoprotein involved in K transport
GWK28_RS12300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GWK28_RS12305	COG0583	DNA-binding transcription factor activity
GWK28_RS12320	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_RS12365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_RS12380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GWK28_RS12395	COG2814	Major facilitator Superfamily
GWK28_RS12400	COG1024	Enoyl-CoA hydratase
GWK28_RS12405	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS12415	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS12440	COG2186	Transcriptional regulator
GWK28_RS12445	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS12455	COG4948	Mandelate Racemase Muconate Lactonizing
GWK28_RS12465	COG2721	sulfolactate sulfo-lyase activity
GWK28_RS12470	COG0697	spore germination
GWK28_RS12485	COG1113	amino acid transport
GWK28_RS12505	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS12525	COG0531	amino acid
GWK28_RS12535	COG1113	amino acid transport
GWK28_RS12570	COG0183	Belongs to the thiolase family
GWK28_RS12575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GWK28_RS12580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GWK28_RS12595	COG3485	protocatechuate 3,4-dioxygenase
GWK28_RS12600	COG1454	alcohol dehydrogenase
GWK28_RS12605	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS12625	COG2814	Major facilitator Superfamily
GWK28_RS12635	COG0583	DNA-binding transcription factor activity
GWK28_RS12645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_RS12685	COG2059	Chromate
GWK28_RS12695	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GWK28_RS12705	COG1230	cation diffusion facilitator family transporter
GWK28_RS12720	COG2814	Major facilitator Superfamily
GWK28_RS12785	COG3328	transposase activity
GWK28_RS12835	COG0582	viral genome integration into host DNA
GWK28_RS12845	COG0446	pyridine nucleotide-disulphide oxidoreductase
GWK28_RS12845	COG1902	pentaerythritol trinitrate reductase activity
GWK28_RS12870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK28_RS12890	COG4172	Belongs to the ABC transporter superfamily
GWK28_RS12895	COG4239	(ABC) transporter, permease
GWK28_RS12900	COG4174	ABC transporter (Permease)
GWK28_RS12910	COG1388	LysM domain
GWK28_RS12910	COG1388	LysM domain
GWK28_RS12910	COG0741	lytic transglycosylase activity
GWK28_RS12910	COG0741	lytic transglycosylase activity
GWK28_RS12915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GWK28_RS12955	COG0583	DNA-binding transcription factor activity
GWK28_RS12960	COG1279	arginine transmembrane transporter activity
GWK28_RS12980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_RS12985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_RS12990	COG0006	proline dipeptidase activity
GWK28_RS13030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GWK28_RS13050	COG3384	dioxygenase
GWK28_RS13060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GWK28_RS13065	COG2878	Part of a membrane complex involved in electron transport
GWK28_RS13070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GWK28_RS13095	COG0768	penicillin binding
GWK28_RS13100	COG0742	ribosomal rna small subunit methyltransferase
GWK28_RS13115	COG0830	nickel cation binding
GWK28_RS13125	COG0804	urea catabolic process
GWK28_RS13165	COG1253	flavin adenine dinucleotide binding
GWK28_RS13170	COG2851	Citrate transporter
GWK28_RS13220	COG1773	rubredoxin
GWK28_RS13225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GWK28_RS13235	COG0583	DNA-binding transcription factor activity
GWK28_RS13265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GWK28_RS13270	COG4181	ATPase activity
GWK28_RS13315	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GWK28_RS13335	COG0306	phosphate transporter
GWK28_RS13345	COG3958	Transketolase
GWK28_RS13350	COG3959	Transketolase, thiamine diphosphate binding domain
GWK28_RS13355	COG2271	Major facilitator Superfamily
GWK28_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS13365	COG0583	DNA-binding transcription factor activity
GWK28_RS13380	COG2223	nitrite transmembrane transporter activity
GWK28_RS13385	COG2207	Transcriptional regulator
GWK28_RS13390	COG2066	Belongs to the glutaminase family
GWK28_RS13395	COG0242	peptide deformylase activity
GWK28_RS13400	COG0477	Major facilitator Superfamily
GWK28_RS13410	COG0028	Belongs to the TPP enzyme family
GWK28_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS13430	COG2267	carboxylic ester hydrolase activity
GWK28_RS13440	COG2271	Major facilitator Superfamily
GWK28_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS13475	COG1414	Transcriptional regulator
GWK28_RS13490	COG1024	Enoyl-CoA hydratase
GWK28_RS13500	COG1215	transferase activity, transferring glycosyl groups
GWK28_RS13505	COG1649	PFAM Uncharacterised BCR, COG1649
GWK28_RS13505	COG0726	polysaccharide deacetylase
GWK28_RS13515	COG4681	YaeQ
GWK28_RS13525	COG0523	cobalamin synthesis protein
GWK28_RS13535	COG1607	acyl-coa hydrolase
GWK28_RS13545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_RS13550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GWK28_RS13555	COG1309	transcriptional regulator
GWK28_RS13580	COG2040	homocysteine
GWK28_RS13585	COG0531	amino acid
GWK28_RS13640	COG1595	DNA-templated transcription, initiation
GWK28_RS13650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_RS13655	COG0477	Major facilitator Superfamily
GWK28_RS13800	COG3617	BRO family, N-terminal domain
GWK28_RS13820	COG0582	viral genome integration into host DNA
GWK28_RS13830	COG0405	Gamma-glutamyltransferase
GWK28_RS13835	COG2814	Major facilitator Superfamily
GWK28_RS13845	COG2050	protein possibly involved in aromatic compounds catabolism
GWK28_RS13860	COG1090	epimerase
GWK28_RS13880	COG0420	3'-5' exonuclease activity
GWK28_RS13905	COG0735	belongs to the Fur family
GWK28_RS13910	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GWK28_RS13930	COG0121	glutamine amidotransferase
GWK28_RS13945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK28_RS13955	COG0210	DNA helicase
GWK28_RS13960	COG2885	chlorophyll binding
GWK28_RS13965	COG0204	Acyl-transferase
GWK28_RS13980	COG2894	cell division
GWK28_RS14000	COG1280	lysine exporter protein (LysE YggA)
GWK28_RS14005	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GWK28_RS14005	COG1674	ftsk spoiiie
GWK28_RS14010	COG0492	ferredoxin-NADP+ reductase activity
GWK28_RS14015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GWK28_RS14025	COG0456	acetyltransferase
GWK28_RS14070	COG1981	membrane
GWK28_RS14085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GWK28_RS14085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK28_RS14105	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS14115	COG0657	acetylesterase activity
GWK28_RS14125	COG0473	3-isopropylmalate dehydrogenase activity
GWK28_RS14130	COG0583	DNA-binding transcription factor activity
GWK28_RS14150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GWK28_RS14175	COG0564	pseudouridine synthase activity
GWK28_RS14185	COG0358	DNA primase activity
GWK28_RS14200	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GWK28_RS14230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GWK28_RS14260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GWK28_RS14270	COG0351	phosphomethylpyrimidine kinase
GWK28_RS14270	COG0352	thiamine-phosphate diphosphorylase activity
GWK28_RS14270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GWK28_RS14275	COG1652	LysM domain
GWK28_RS14300	COG1399	metal-binding, possibly nucleic acid-binding protein
GWK28_RS14305	COG3101	peptidyl-lysine hydroxylation
GWK28_RS14310	COG0009	L-threonylcarbamoyladenylate synthase
GWK28_RS14315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GWK28_RS14320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GWK28_RS14335	COG4106	trans-aconitate 2-methyltransferase activity
GWK28_RS14350	COG0596	Alpha beta hydrolase
GWK28_RS14350	COG2226	methyltransferase
GWK28_RS14350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_RS14355	COG1877	trehalose-phosphatase activity
GWK28_RS14360	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GWK28_RS14365	COG2223	nitrite transmembrane transporter activity
GWK28_RS14385	COG1196	nuclear chromosome segregation
GWK28_RS14395	COG0730	response to heat
GWK28_RS14410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GWK28_RS14420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK28_RS14470	COG0489	protein tyrosine kinase activity
GWK28_RS14480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_RS14480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_RS14510	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GWK28_RS14515	COG2081	HI0933 family
GWK28_RS14525	COG0668	transmembrane transport
GWK28_RS14545	COG0583	DNA-binding transcription factor activity
GWK28_RS14565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GWK28_RS14570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK28_RS14600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GWK28_RS14640	COG0745	RESPONSE REGULATOR receiver
GWK28_RS14660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_RS14675	COG0384	phenazine biosynthesis protein PhzF
GWK28_RS14700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GWK28_RS14715	COG0583	DNA-binding transcription factor activity
GWK28_RS14750	COG0583	DNA-binding transcription factor activity
GWK28_RS14765	COG0583	DNA-binding transcription factor activity
GWK28_RS14770	COG1053	succinate dehydrogenase
GWK28_RS14780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GWK28_RS14785	COG2814	Major facilitator Superfamily
GWK28_RS14790	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS14795	COG0583	DNA-binding transcription factor activity
GWK28_RS14800	COG1063	alcohol dehydrogenase
GWK28_RS14830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GWK28_RS14835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GWK28_RS14840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK28_RS14860	COG2132	Multicopper oxidase
GWK28_RS14870	COG0561	phosphatase activity
GWK28_RS14875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GWK28_RS14900	COG1214	PFAM Peptidase M22, glycoprotease
GWK28_RS14945	COG1388	LysM domain
GWK28_RS14945	COG1134	teichoic acid transport
GWK28_RS14950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GWK28_RS14960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GWK28_RS14965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GWK28_RS14970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GWK28_RS15030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GWK28_RS15040	COG1846	Transcriptional regulator
GWK28_RS15045	COG1764	response to oxidative stress
GWK28_RS15085	COG0037	tRNA processing
GWK28_RS15095	COG0248	Ppx GppA phosphatase
GWK28_RS15125	COG0072	phenylalanine-tRNA ligase activity
GWK28_RS15175	COG1238	metal cluster binding
GWK28_RS15180	COG0625	glutathione transferase activity
GWK28_RS15195	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_RS15200	COG3028	Belongs to the UPF0307 family
GWK28_RS15205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GWK28_RS15225	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GWK28_RS15230	COG0617	tRNA 3'-terminal CCA addition
GWK28_RS15235	COG1555	photosystem II stabilization
GWK28_RS15240	COG3956	TIGRFAM MazG family protein
GWK28_RS15250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GWK28_RS15270	COG0784	Response regulator, receiver
GWK28_RS15270	COG2205	protein histidine kinase activity
GWK28_RS15270	COG5002	protein histidine kinase activity
GWK28_RS15275	COG1024	Enoyl-CoA hydratase
GWK28_RS15280	COG2084	Dehydrogenase
GWK28_RS15285	COG3622	Belongs to the hyi family
GWK28_RS15315	COG0697	spore germination
GWK28_RS15325	COG2814	Major facilitator Superfamily
GWK28_RS15335	COG3328	transposase activity
GWK28_RS15345	COG0492	ferredoxin-NADP+ reductase activity
GWK28_RS15350	COG0431	NADPH-dependent FMN reductase
GWK28_RS15355	COG0798	PFAM Bile acid sodium symporter
GWK28_RS15365	COG0640	Transcriptional regulator
GWK28_RS15400	COG3328	transposase activity
GWK28_RS15415	COG2132	Multicopper oxidase
GWK28_RS15430	COG2205	protein histidine kinase activity
GWK28_RS15465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GWK28_RS15475	COG0583	DNA-binding transcription factor activity
GWK28_RS15485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GWK28_RS15500	COG0084	hydrolase, TatD family'
GWK28_RS15515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GWK28_RS15540	COG2130	NADP-dependent
GWK28_RS15545	COG1309	transcriptional regulator
GWK28_RS15565	COG1979	alcohol dehydrogenase
GWK28_RS15575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GWK28_RS15590	COG0604	alcohol dehydrogenase
GWK28_RS15590	COG3321	synthase
GWK28_RS15595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GWK28_RS15600	COG0583	DNA-binding transcription factor activity
GWK28_RS15605	COG4221	oxidoreductase activity
GWK28_RS15760	COG0440	acetolactate synthase activity
GWK28_RS15765	COG0028	Belongs to the TPP enzyme family
GWK28_RS15790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GWK28_RS15795	COG0577	efflux transmembrane transporter activity
GWK28_RS15795	COG1136	(ABC) transporter
GWK28_RS15800	COG1538	Outer membrane efflux protein
GWK28_RS15815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GWK28_RS15820	COG1162	GTPase activity
GWK28_RS15830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GWK28_RS15870	COG1426	Protein conserved in bacteria
GWK28_RS15905	COG0793	Belongs to the peptidase S41A family
GWK28_RS15920	COG2267	carboxylic ester hydrolase activity
GWK28_RS15930	COG1012	belongs to the aldehyde dehydrogenase family
GWK28_RS15935	COG3265	gluconokinase activity
GWK28_RS15945	COG0800	Aldolase
GWK28_RS15955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GWK28_RS15960	COG0280	phosphate acetyltransferase
GWK28_RS15960	COG0857	belongs to the CobB CobQ family
GWK28_RS15965	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_RS15965	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GWK28_RS15985	COG0740	serine-type endopeptidase activity
GWK28_RS15995	COG4774	siderophore transport
GWK28_RS16005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GWK28_RS16015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GWK28_RS16015	COG2813	Specifically methylates the guanine in position
GWK28_RS16165	COG0788	formyltetrahydrofolate deformylase activity
GWK28_RS16190	COG4651	solute:proton antiporter activity
GWK28_RS16190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK28_RS16210	COG0724	RNA recognition motif
GWK28_RS16215	COG0210	DNA helicase
GWK28_RS16240	COG1733	regulation of RNA biosynthetic process
GWK28_RS16250	COG2900	Belongs to the SlyX family
GWK28_RS16255	COG0488	(ABC) transporter
GWK28_RS16270	COG1560	Kdo2-lipid A biosynthetic process
GWK28_RS16280	COG1301	dicarboxylic acid transport
GWK28_RS16335	COG0473	3-isopropylmalate dehydrogenase activity
GWK28_RS16390	COG0583	DNA-binding transcription factor activity
GWK28_RS16400	COG0625	glutathione transferase activity
GWK28_RS16405	COG2378	regulation of single-species biofilm formation
GWK28_RS16410	COG0546	phosphoglycolate phosphatase activity
GWK28_RS16420	COG1530	ribonuclease E activity
GWK28_RS16425	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_RS16440	COG0583	DNA-binding transcription factor activity
GWK28_RS16445	COG4221	oxidoreductase activity
GWK28_RS16450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GWK28_RS16460	COG0534	Mate efflux family protein
GWK28_RS16475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GWK28_RS16565	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GWK28_RS16570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GWK28_RS16585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GWK28_RS16595	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GWK28_RS16595	COG0644	oxidoreductase
GWK28_RS16605	COG0425	Belongs to the sulfur carrier protein TusA family
GWK28_RS16610	COG4535	Mg2 and Co2 transporter CorC
GWK28_RS16620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GWK28_RS16640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GWK28_RS16645	COG0475	glutathione-regulated potassium exporter activity
GWK28_RS16645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GWK28_RS16660	COG0484	heat shock protein binding
GWK28_RS16665	COG0789	Transcriptional regulator
GWK28_RS16670	COG0598	Magnesium transport protein CorA
GWK28_RS16690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GWK28_RS16695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_RS16700	COG1074	ATP-dependent DNA helicase activity
GWK28_RS16705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GWK28_RS16725	COG2226	methyltransferase
GWK28_RS16740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GWK28_RS16755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GWK28_RS16770	COG2111	Na H antiporter
GWK28_RS16770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GWK28_RS16775	COG1006	Multisubunit Na H antiporter MnhC subunit
GWK28_RS16780	COG0651	ATP synthesis coupled electron transport
GWK28_RS16785	COG1863	multisubunit Na H antiporter MnhE subunit
GWK28_RS16790	COG2212	antiporter activity
GWK28_RS16795	COG1320	monovalent cation:proton antiporter activity
GWK28_RS16810	COG0195	Participates in both transcription termination and antitermination
GWK28_RS16860	COG0237	dephospho-CoA kinase activity
GWK28_RS16870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GWK28_RS16885	COG0497	DNA recombination
GWK28_RS16895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GWK28_RS16925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GWK28_RS16925	COG2169	Transcriptional regulator
GWK28_RS16930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GWK28_RS16995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GWK28_RS17010	COG0326	Molecular chaperone. Has ATPase activity
GWK28_RS17025	COG2056	Na+-H+ antiporter family
GWK28_RS17125	COG0546	phosphoglycolate phosphatase activity
GWK28_RS17130	COG1716	ATPase activity
GWK28_RS17175	COG0181	hydroxymethylbilane synthase activity
GWK28_RS17185	COG3275	phosphorelay sensor kinase activity
GWK28_RS17205	COG1538	Outer membrane efflux protein
GWK28_RS17210	COG0697	spore germination
GWK28_RS17235	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GWK28_RS17240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GWK28_RS17245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GWK28_RS17250	COG0772	Belongs to the SEDS family
GWK28_RS17275	COG4974	Belongs to the 'phage' integrase family
GWK28_RS17280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_RS17290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GWK28_RS17300	COG2197	response regulator
GWK28_RS17315	COG0793	Belongs to the peptidase S41A family
GWK28_RS17320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GWK28_RS17325	COG0795	lipopolysaccharide-transporting ATPase activity
GWK28_RS17365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK28_RS17365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GWK28_RS17375	COG0004	ammonium transporteR
GWK28_RS17380	COG0347	Belongs to the P(II) protein family
GWK28_RS17390	COG0606	chelatase, subunit chli
GWK28_RS17395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GWK28_RS17405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GWK28_RS17420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GWK28_RS17435	COG0318	PFAM AMP-dependent synthetase and ligase
GWK28_RS17445	COG0477	Major facilitator Superfamily
GWK28_RS17450	COG2860	membrane
GWK28_RS17460	COG1253	flavin adenine dinucleotide binding
GWK28_RS17470	COG0477	Major facilitator Superfamily
GWK28_RS17480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GWK28_RS17485	COG0745	RESPONSE REGULATOR receiver
GWK28_RS17490	COG2205	protein histidine kinase activity
GWK28_RS17495	COG4452	Inner membrane protein CreD
GWK28_RS17535	COG0655	NAD(P)H dehydrogenase (quinone) activity
GWK28_RS17545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GWK28_RS17580	COG1309	transcriptional regulator
GWK28_RS17615	COG0758	DNA mediated transformation
GWK28_RS17625	COG0697	spore germination
GWK28_RS17630	COG1309	transcriptional regulator
GWK28_RS17650	COG0386	Belongs to the glutathione peroxidase family
GWK28_RS17715	COG1121	(ABC) transporter
GWK28_RS17720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GWK28_RS17725	COG1280	lysine exporter protein (LysE YggA)
GWK28_RS17730	COG2837	iron assimilation
GWK28_RS17735	COG0281	malic enzyme
GWK28_RS17780	COG0519	Catalyzes the synthesis of GMP from XMP
GWK28_RS17780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GWK28_RS17785	COG4399	Belongs to the UPF0754 family
GWK28_RS17790	COG2259	Doxx family
GWK28_RS17795	COG0586	Pfam SNARE associated Golgi protein
GWK28_RS17810	COG1192	Involved in chromosome partitioning
GWK28_RS17820	COG0271	Belongs to the BolA IbaG family
GWK28_RS17860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GWK28_RS17860	COG3321	synthase
GWK28_RS17860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GWK28_RS17860	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GWK28_RS17865	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS17875	COG2197	response regulator
GWK28_RS17885	COG3916	Acyl-homoserine-lactone synthase
GWK28_RS17890	COG0477	Major facilitator Superfamily
GWK28_RS17895	COG1024	Enoyl-CoA hydratase
GWK28_RS17900	COG1024	Enoyl-CoA hydratase
GWK28_RS17905	COG1960	acyl-CoA dehydrogenase activity
GWK28_RS17910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GWK28_RS17930	COG1113	amino acid transport
GWK28_RS17935	COG1113	amino acid transport
GWK28_RS17940	COG0251	oxidation-reduction process
GWK28_RS17980	COG0564	pseudouridine synthase activity
GWK28_RS18065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GWK28_RS18080	COG1802	Transcriptional regulator
GWK28_RS18090	COG1448	Aminotransferase
GWK28_RS18095	COG0277	FAD linked oxidase domain protein
GWK28_RS18105	COG2186	Transcriptional regulator
GWK28_RS18115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GWK28_RS18125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GWK28_RS18140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GWK28_RS18145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GWK28_RS18150	COG1216	Glycosyl transferase, family 2
GWK28_RS18160	COG1215	transferase activity, transferring glycosyl groups
GWK28_RS18170	COG1216	Glycosyl transferase, family 2
GWK28_RS18170	COG0463	Glycosyl transferase, family 2
GWK28_RS18190	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GWK28_RS18200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GWK28_RS18205	COG1596	polysaccharide export
GWK28_RS18230	COG0728	peptidoglycan biosynthetic process
GWK28_RS18235	COG3023	N-Acetylmuramoyl-L-alanine amidase
GWK28_RS18295	COG0546	phosphoglycolate phosphatase activity
GWK28_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
GWK28_RS18320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_RS18325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GWK28_RS18330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GWK28_RS18335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GWK28_RS18340	COG1116	anion transmembrane transporter activity
GWK28_RS18345	COG1309	transcriptional regulator
GWK28_RS18350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GWK28_RS18360	COG0196	riboflavin kinase activity
GWK28_RS18365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GWK28_RS18375	COG1047	Peptidyl-prolyl cis-trans
GWK28_RS18415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GWK28_RS18420	COG0657	acetylesterase activity
GWK28_RS18470	COG2951	lytic endotransglycosylase activity
GWK28_RS18475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GWK28_RS18490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GWK28_RS18500	COG0671	phosphoesterase, PA-phosphatase related
GWK28_RS18505	COG0861	Integral membrane protein TerC family
GWK28_RS18515	COG0754	glutathionylspermidine amidase activity
GWK28_RS18525	COG0402	S-adenosylhomocysteine deaminase activity
GWK28_RS18540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GWK28_RS18545	COG1230	cation diffusion facilitator family transporter
GWK28_RS18560	COG0706	membrane insertase activity
GWK28_RS18625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_RS18630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GWK28_RS18630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GWK28_RS18680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK28_RS18680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GWK28_RS18695	COG0587	DNA-directed DNA polymerase activity
GWK28_RS18740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GWK28_RS18800	COG0358	DNA primase activity
GWK28_RS18925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GWK28_RS18945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GWK28_RS19040	COG3586	endonuclease activity
GWK28_RS19175	COG3328	transposase activity
GWK28_RS19260	COG0582	viral genome integration into host DNA
GWK28_RS19290	COG1660	Displays ATPase and GTPase activities
GWK28_RS19340	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GWK28_RS19345	COG3657	addiction module killer protein
GWK28_RS19350	COG2826	transposase and inactivated derivatives, IS30 family
GWK28_RS19375	COG1324	tolerance protein
GWK28_RS19380	COG0673	inositol 2-dehydrogenase activity
GWK28_RS19400	COG2826	transposase and inactivated derivatives, IS30 family
GWK28_RS19465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GWK28_RS19485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GWK28_RS19495	COG5002	protein histidine kinase activity
GWK28_RS19500	COG0745	RESPONSE REGULATOR receiver
GWK28_RS19515	COG0488	(ABC) transporter
GWK28_RS19520	COG3173	Aminoglycoside phosphotransferase
GWK28_RS19570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GWK28_RS19575	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GWK28_RS19590	COG0789	Transcriptional regulator
GWK28_RS19645	COG3328	transposase activity