locus-tag	class	description
L2Z44_RS00005	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS00010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z44_RS00040	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z44_RS00045	COG0339	signal peptide processing
L2Z44_RS00050	COG0557	exoribonuclease II activity
L2Z44_RS00095	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z44_RS00100	COG2169	Transcriptional regulator
L2Z44_RS00105	COG0697	spore germination
L2Z44_RS00110	COG1295	ribonuclease BN
L2Z44_RS00145	COG1702	phosphate starvation-inducible protein PhoH
L2Z44_RS00155	COG0739	heme binding
L2Z44_RS00155	COG0741	lytic transglycosylase activity
L2Z44_RS00155	COG1196	nuclear chromosome segregation
L2Z44_RS00185	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z44_RS00190	COG1183	phosphatidylcholine synthase activity
L2Z44_RS00235	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS00240	COG1309	transcriptional regulator
L2Z44_RS00255	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z44_RS00260	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS00280	COG2969	positive regulation of protein catabolic process
L2Z44_RS00290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z44_RS00300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L2Z44_RS00305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z44_RS00310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z44_RS00330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z44_RS00340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z44_RS00345	COG1408	metallophosphoesterase
L2Z44_RS00355	COG2199	diguanylate cyclase activity
L2Z44_RS00415	COG1607	acyl-coa hydrolase
L2Z44_RS00445	COG2350	Protein conserved in bacteria
L2Z44_RS00455	COG0613	PHP domain protein
L2Z44_RS00460	COG3781	membrane
L2Z44_RS00470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z44_RS00475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z44_RS00485	COG1862	Preprotein translocase
L2Z44_RS00520	COG2205	protein histidine kinase activity
L2Z44_RS00525	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z44_RS00540	COG0726	polysaccharide deacetylase
L2Z44_RS00545	COG0438	transferase activity, transferring glycosyl groups
L2Z44_RS00560	COG1091	dTDP-4-dehydrorhamnose reductase activity
L2Z44_RS00575	COG1215	transferase activity, transferring glycosyl groups
L2Z44_RS00625	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS00630	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS00640	COG2205	protein histidine kinase activity
L2Z44_RS00645	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS00650	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z44_RS00670	COG2096	Adenosyltransferase
L2Z44_RS00720	COG0285	dihydrofolate synthase activity
L2Z44_RS00740	COG0450	alkyl hydroperoxide reductase
L2Z44_RS00755	COG0477	Major facilitator Superfamily
L2Z44_RS00760	COG1272	protein, Hemolysin III
L2Z44_RS00790	COG0183	Belongs to the thiolase family
L2Z44_RS00795	COG2207	Transcriptional regulator
L2Z44_RS00815	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z44_RS00835	COG0183	Belongs to the thiolase family
L2Z44_RS00845	COG2885	chlorophyll binding
L2Z44_RS00845	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z44_RS00855	COG1690	Belongs to the RtcB family
L2Z44_RS00860	COG0833	amino acid
L2Z44_RS00870	COG2233	PERMEase
L2Z44_RS00875	COG1217	gtp-binding protein TYPA
L2Z44_RS00900	COG2094	Belongs to the DNA glycosylase MPG family
L2Z44_RS00905	COG4772	TonB-dependent receptor
L2Z44_RS00910	COG1902	pentaerythritol trinitrate reductase activity
L2Z44_RS00925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z44_RS00930	COG0354	folic acid binding
L2Z44_RS00940	COG3189	MarR family transcriptional regulator
L2Z44_RS00945	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z44_RS00950	COG3422	double-strand break repair
L2Z44_RS00990	COG0840	transmembrane signaling receptor activity
L2Z44_RS01010	COG5510	response to toxic substance
L2Z44_RS01020	COG2832	Protein of unknown function (DUF454)
L2Z44_RS01025	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z44_RS01065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z44_RS01075	COG1289	transmembrane transporter activity
L2Z44_RS01080	COG2814	Major facilitator Superfamily
L2Z44_RS01100	COG1115	amino acid carrier protein
L2Z44_RS01105	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z44_RS01110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z44_RS01115	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z44_RS01120	COG3590	peptidase
L2Z44_RS01145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z44_RS01155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z44_RS01160	COG1077	Cell shape determining protein MreB Mrl
L2Z44_RS01165	COG1792	Involved in formation and maintenance of cell shape
L2Z44_RS01170	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z44_RS01175	COG0424	maF-like protein
L2Z44_RS01180	COG1530	ribonuclease E activity
L2Z44_RS01190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z44_RS01200	COG0560	Phosphoserine phosphatase
L2Z44_RS01210	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z44_RS01235	COG2207	Transcriptional regulator
L2Z44_RS01255	COG1113	amino acid transport
L2Z44_RS01260	COG2828	Protein conserved in bacteria
L2Z44_RS01265	COG0142	geranyltranstransferase activity
L2Z44_RS01270	COG2315	Protein conserved in bacteria
L2Z44_RS01285	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z44_RS01305	COG2194	sulfuric ester hydrolase activity
L2Z44_RS01310	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS01315	COG0642	Histidine kinase
L2Z44_RS01325	COG0004	ammonium transporteR
L2Z44_RS01330	COG0583	DNA-binding transcription factor activity
L2Z44_RS01350	COG0525	valine-tRNA ligase activity
L2Z44_RS01360	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS01370	COG0393	Putative heavy-metal-binding
L2Z44_RS01375	COG0393	Putative heavy-metal-binding
L2Z44_RS01380	COG1538	Outer membrane efflux protein
L2Z44_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS01395	COG0671	phosphoesterase, PA-phosphatase related
L2Z44_RS01425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z44_RS01440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z44_RS01440	COG1648	precorrin-2 dehydrogenase activity
L2Z44_RS01445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z44_RS01450	COG1733	regulation of RNA biosynthetic process
L2Z44_RS01460	COG0531	amino acid
L2Z44_RS01475	COG0321	lipoyl(octanoyl) transferase activity
L2Z44_RS01480	COG2921	Belongs to the UPF0250 family
L2Z44_RS01515	COG2009	succinate dehydrogenase
L2Z44_RS01520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z44_RS01525	COG1053	succinate dehydrogenase
L2Z44_RS01530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z44_RS01555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z44_RS01575	COG2354	Protein conserved in bacteria
L2Z44_RS01580	COG2321	neutral zinc metallopeptidase
L2Z44_RS01600	COG2843	Capsule synthesis protein
L2Z44_RS01615	COG0589	response to stress
L2Z44_RS01625	COG0251	oxidation-reduction process
L2Z44_RS01645	COG0505	Belongs to the CarA family
L2Z44_RS01670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z44_RS01675	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z44_RS01725	COG0477	Major facilitator Superfamily
L2Z44_RS01730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z44_RS01745	COG1597	lipid kinase activity
L2Z44_RS01750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z44_RS01770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z44_RS01775	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z44_RS01795	COG0741	lytic transglycosylase activity
L2Z44_RS01815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z44_RS01865	COG0789	Transcriptional regulator
L2Z44_RS01925	COG2184	nucleotidyltransferase activity
L2Z44_RS01935	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Z44_RS01985	COG0582	viral genome integration into host DNA
L2Z44_RS01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z44_RS02020	COG3811	Belongs to the UPF0386 family
L2Z44_RS02060	COG0778	Nitroreductase
L2Z44_RS02075	COG1929	Belongs to the glycerate kinase type-1 family
L2Z44_RS02080	COG0243	molybdopterin cofactor binding
L2Z44_RS02085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z44_RS02090	COG3339	Conserved Protein
L2Z44_RS02100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z44_RS02115	COG1113	amino acid transport
L2Z44_RS02125	COG0019	diaminopimelate decarboxylase activity
L2Z44_RS02135	COG2267	carboxylic ester hydrolase activity
L2Z44_RS02140	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS02145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z44_RS02175	COG0463	Glycosyl transferase, family 2
L2Z44_RS02195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS02225	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z44_RS02230	COG1136	(ABC) transporter
L2Z44_RS02235	COG2333	competence protein COMEC
L2Z44_RS02235	COG0658	competence protein
L2Z44_RS02245	COG0616	signal peptide processing
L2Z44_RS02245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z44_RS02250	COG0596	Alpha beta hydrolase
L2Z44_RS02255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z44_RS02265	COG0628	permease
L2Z44_RS02300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z44_RS02320	COG0823	Involved in the tonB-independent uptake of proteins
L2Z44_RS02340	COG0824	Thioesterase
L2Z44_RS02345	COG1473	amidohydrolase
L2Z44_RS02365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z44_RS02365	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z44_RS02370	COG2814	Major facilitator Superfamily
L2Z44_RS02380	COG1024	Enoyl-CoA hydratase
L2Z44_RS02385	COG1056	cytidyltransferase-related domain
L2Z44_RS02385	COG1051	belongs to the nudix hydrolase family
L2Z44_RS02395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z44_RS02410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z44_RS02425	COG4625	pathogenesis
L2Z44_RS02430	COG0583	DNA-binding transcription factor activity
L2Z44_RS02435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z44_RS02440	COG4208	sulfate ABC transporter
L2Z44_RS02445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z44_RS02455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z44_RS02460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z44_RS02465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z44_RS02485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z44_RS02500	COG0681	Belongs to the peptidase S26 family
L2Z44_RS02515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z44_RS02525	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z44_RS02530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z44_RS02540	COG4221	oxidoreductase activity
L2Z44_RS02570	COG0436	Aminotransferase
L2Z44_RS02590	COG0556	nucleotide-excision repair
L2Z44_RS02645	COG2070	2-Nitropropane dioxygenase
L2Z44_RS02675	COG1215	transferase activity, transferring glycosyl groups
L2Z44_RS02690	COG0415	Belongs to the DNA photolyase family
L2Z44_RS02700	COG1252	NADH dehydrogenase
L2Z44_RS02705	COG1686	Belongs to the peptidase S11 family
L2Z44_RS02720	COG1187	pseudouridine synthase activity
L2Z44_RS02745	COG0477	Major facilitator Superfamily
L2Z44_RS02750	COG0583	DNA-binding transcription factor activity
L2Z44_RS02755	COG1823	symporter activity
L2Z44_RS02765	COG0612	Peptidase, M16
L2Z44_RS02820	COG0352	thiamine-phosphate diphosphorylase activity
L2Z44_RS02855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z44_RS02880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z44_RS02885	COG0076	glutamate decarboxylase activity
L2Z44_RS02895	COG1522	sequence-specific DNA binding
L2Z44_RS02900	COG3961	Belongs to the TPP enzyme family
L2Z44_RS02905	COG1113	amino acid transport
L2Z44_RS02910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z44_RS02915	COG0573	inorganic phosphate transmembrane transporter activity
L2Z44_RS02925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z44_RS02930	COG0616	signal peptide processing
L2Z44_RS02965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z44_RS02970	COG1686	Belongs to the peptidase S11 family
L2Z44_RS02995	COG0583	DNA-binding transcription factor activity
L2Z44_RS03000	COG1067	ATP-dependent peptidase activity
L2Z44_RS03005	COG2211	Major facilitator Superfamily
L2Z44_RS03045	COG1966	Carbon starvation protein
L2Z44_RS03050	COG2879	small protein
L2Z44_RS03090	COG1741	Belongs to the pirin family
L2Z44_RS03100	COG2964	Protein conserved in bacteria
L2Z44_RS03115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z44_RS03120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z44_RS03125	COG4605	iron ion homeostasis
L2Z44_RS03130	COG4604	ABC transporter, ATP-binding protein
L2Z44_RS03135	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z44_RS03140	COG4774	siderophore transport
L2Z44_RS03150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z44_RS03155	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z44_RS03160	COG1535	isochorismatase
L2Z44_RS03160	COG3433	isochorismatase activity
L2Z44_RS03170	COG1132	(ABC) transporter
L2Z44_RS03175	COG1132	(ABC) transporter
L2Z44_RS03180	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z44_RS03205	COG3739	integral membrane protein
L2Z44_RS03225	COG0302	gtp cyclohydrolase
L2Z44_RS03235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z44_RS03265	COG0308	aminopeptidase N
L2Z44_RS03270	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z44_RS03285	COG0174	glutamine synthetase
L2Z44_RS03295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z44_RS03330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z44_RS03335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z44_RS03340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z44_RS03360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z44_RS03365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z44_RS03370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z44_RS03385	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS03390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z44_RS03395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z44_RS03405	COG2223	nitrite transmembrane transporter activity
L2Z44_RS03415	COG0024	Methionine aminopeptidase
L2Z44_RS03420	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z44_RS03435	COG2207	Transcriptional regulator
L2Z44_RS03460	COG2951	lytic endotransglycosylase activity
L2Z44_RS03465	COG0772	Belongs to the SEDS family
L2Z44_RS03480	COG0842	Transport permease protein
L2Z44_RS03485	COG1131	(ABC) transporter
L2Z44_RS03530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS03545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z44_RS03550	COG0826	peptidase U32
L2Z44_RS03555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z44_RS03570	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z44_RS03580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z44_RS03595	COG0642	Histidine kinase
L2Z44_RS03605	COG0494	nUDIX hydrolase
L2Z44_RS03615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z44_RS03620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z44_RS03625	COG3139	Protein of unknown function (DUF1315)
L2Z44_RS03630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z44_RS03635	COG1301	dicarboxylic acid transport
L2Z44_RS03640	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS03655	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z44_RS03665	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z44_RS03670	COG1234	tRNA 3'-trailer cleavage
L2Z44_RS03700	COG2363	Small membrane protein
L2Z44_RS03725	COG0513	Belongs to the DEAD box helicase family
L2Z44_RS03735	COG0778	Nitroreductase
L2Z44_RS03765	COG1286	toxin biosynthetic process
L2Z44_RS03790	COG4783	chaperone-mediated protein folding
L2Z44_RS03795	COG1610	YqeY-like protein
L2Z44_RS03825	COG2815	serine threonine protein kinase
L2Z44_RS03825	COG0515	serine threonine protein kinase
L2Z44_RS03850	COG2831	hemolysin activation secretion protein
L2Z44_RS03855	COG3210	domain, Protein
L2Z44_RS03855	COG3210	domain, Protein
L2Z44_RS03880	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
L2Z44_RS03950	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z44_RS03975	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z44_RS03980	COG0786	glutamate:sodium symporter activity
L2Z44_RS03990	COG2186	Transcriptional regulator
L2Z44_RS04070	COG2995	paraquat-inducible protein a
L2Z44_RS04075	COG3008	intermembrane lipid transfer
L2Z44_RS04075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z44_RS04085	COG1794	racemase activity, acting on amino acids and derivatives
L2Z44_RS04115	COG1301	dicarboxylic acid transport
L2Z44_RS04125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z44_RS04130	COG2011	ABC-type metal ion transport system permease component
L2Z44_RS04135	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z44_RS04145	COG0151	Belongs to the GarS family
L2Z44_RS04150	COG0138	bifunctional purine biosynthesis protein purh
L2Z44_RS04155	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z44_RS04185	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z44_RS04195	COG1305	Transglutaminase-like
L2Z44_RS04205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z44_RS04210	COG0305	Participates in initiation and elongation during chromosome replication
L2Z44_RS04235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z44_RS04245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z44_RS04250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z44_RS04275	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z44_RS04275	COG0726	polysaccharide deacetylase
L2Z44_RS04280	COG1215	transferase activity, transferring glycosyl groups
L2Z44_RS04285	COG3658	cytochrome
L2Z44_RS04295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z44_RS04310	COG0583	DNA-binding transcription factor activity
L2Z44_RS04330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z44_RS04335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z44_RS04350	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS04355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z44_RS04360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS04385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z44_RS04390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z44_RS04400	COG2205	protein histidine kinase activity
L2Z44_RS04405	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS04410	COG0174	glutamine synthetase
L2Z44_RS04430	COG0729	surface antigen
L2Z44_RS04455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z44_RS04460	COG2814	Major facilitator Superfamily
L2Z44_RS04475	COG0583	DNA-binding transcription factor activity
L2Z44_RS04490	COG1187	pseudouridine synthase activity
L2Z44_RS04510	COG0802	atpase or kinase
L2Z44_RS04515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z44_RS04525	COG1923	regulation of RNA biosynthetic process
L2Z44_RS04530	COG0697	spore germination
L2Z44_RS04555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z44_RS04560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z44_RS04560	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z44_RS04565	COG4302	ethanolamine ammonia-lyase activity
L2Z44_RS04570	COG4303	Ethanolamine ammonia lyase large subunit
L2Z44_RS04575	COG0531	amino acid
L2Z44_RS04595	COG1454	alcohol dehydrogenase
L2Z44_RS04600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z44_RS04625	COG0308	aminopeptidase N
L2Z44_RS04665	COG1605	Chorismate mutase
L2Z44_RS04685	COG1309	transcriptional regulator
L2Z44_RS04695	COG0668	transmembrane transport
L2Z44_RS04725	COG4773	Receptor
L2Z44_RS04745	COG0488	(ABC) transporter
L2Z44_RS04750	COG0589	response to stress
L2Z44_RS04775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z44_RS04785	COG3135	benzoate transporter
L2Z44_RS04790	COG1522	sequence-specific DNA binding
L2Z44_RS04800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z44_RS04805	COG0583	DNA-binding transcription factor activity
L2Z44_RS04815	COG0183	Belongs to the thiolase family
L2Z44_RS04825	COG2030	dehydratase
L2Z44_RS04830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z44_RS04845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z44_RS04860	COG0824	Thioesterase
L2Z44_RS04865	COG1454	alcohol dehydrogenase
L2Z44_RS04875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z44_RS04895	COG0069	glutamate synthase activity
L2Z44_RS04950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z44_RS05145	COG2814	Major facilitator Superfamily
L2Z44_RS05160	COG0511	ligase activity, forming carbon-carbon bonds
L2Z44_RS05180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z44_RS05180	COG1116	anion transmembrane transporter activity
L2Z44_RS05185	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS05195	COG2146	nitrite reductase [NAD(P)H] activity
L2Z44_RS05195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z44_RS05200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z44_RS05205	COG0243	molybdopterin cofactor binding
L2Z44_RS05215	COG0243	molybdopterin cofactor binding
L2Z44_RS05220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z44_RS05235	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z44_RS05235	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z44_RS05240	COG0303	'Molybdopterin
L2Z44_RS05250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z44_RS05255	COG0697	spore germination
L2Z44_RS05275	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z44_RS05280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z44_RS05335	COG2204	response regulator
L2Z44_RS05340	COG3852	Histidine kinase
L2Z44_RS05365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z44_RS05370	COG0575	Belongs to the CDS family
L2Z44_RS05385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z44_RS05405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z44_RS05420	COG2137	regulation of response to DNA damage stimulus
L2Z44_RS05430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z44_RS05435	COG1011	Hydrolase
L2Z44_RS05460	COG1522	sequence-specific DNA binding
L2Z44_RS05470	COG1113	amino acid transport
L2Z44_RS05490	COG0659	secondary active sulfate transmembrane transporter activity
L2Z44_RS05495	COG2135	peptidase activity
L2Z44_RS05510	COG3300	MHYT domain
L2Z44_RS05510	COG5001	Diguanylate cyclase
L2Z44_RS05530	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z44_RS05530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z44_RS05530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z44_RS05535	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z44_RS05540	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z44_RS05540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z44_RS05570	COG0024	Methionine aminopeptidase
L2Z44_RS05575	COG0583	DNA-binding transcription factor activity
L2Z44_RS05585	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z44_RS05590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z44_RS05595	COG0516	GMP reductase activity
L2Z44_RS05595	COG0517	IMP dehydrogenase activity
L2Z44_RS05620	COG0552	protein localization to endoplasmic reticulum
L2Z44_RS05630	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z44_RS05645	COG4890	Cyd operon protein YbgT
L2Z44_RS05650	COG1294	oxidase, subunit
L2Z44_RS05665	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z44_RS05675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z44_RS05680	COG4774	siderophore transport
L2Z44_RS05695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z44_RS05700	COG0569	domain protein
L2Z44_RS05705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z44_RS05735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z44_RS05740	COG0542	response to heat
L2Z44_RS05765	COG1902	pentaerythritol trinitrate reductase activity
L2Z44_RS05765	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z44_RS05810	COG2323	membrane
L2Z44_RS05815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z44_RS05825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z44_RS05830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z44_RS05835	COG0183	Belongs to the thiolase family
L2Z44_RS05840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z44_RS05845	COG0596	Alpha beta hydrolase
L2Z44_RS05850	COG2271	Major facilitator Superfamily
L2Z44_RS05855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z44_RS05860	COG3485	protocatechuate 3,4-dioxygenase
L2Z44_RS05865	COG3485	protocatechuate 3,4-dioxygenase
L2Z44_RS05870	COG0710	3-dehydroquinate dehydratase activity
L2Z44_RS05875	COG3420	alginic acid biosynthetic process
L2Z44_RS05880	COG3659	wide pore channel activity
L2Z44_RS05885	COG4993	Dehydrogenase
L2Z44_RS05895	COG2391	methyltransferase activity
L2Z44_RS05910	COG1414	Transcriptional regulator
L2Z44_RS05915	COG0583	DNA-binding transcription factor activity
L2Z44_RS05920	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS05945	COG2814	Major facilitator Superfamily
L2Z44_RS05955	COG0154	amidase activity
L2Z44_RS05975	COG4638	Rieske (2fe-2S)
L2Z44_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS05995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS06005	COG3733	amine oxidase
L2Z44_RS06015	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS06020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z44_RS06025	COG0183	Belongs to the thiolase family
L2Z44_RS06030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z44_RS06035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z44_RS06045	COG4829	muconolactone delta-isomerase
L2Z44_RS06050	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z44_RS06055	COG0583	DNA-binding transcription factor activity
L2Z44_RS06065	COG2186	Transcriptional regulator
L2Z44_RS06085	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS06090	COG3231	kanamycin kinase activity
L2Z44_RS06105	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS06115	COG3829	transcription factor binding
L2Z44_RS06125	COG3162	membrane
L2Z44_RS06140	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS06155	COG0753	catalase activity
L2Z44_RS06175	COG1846	Transcriptional regulator
L2Z44_RS06190	COG0006	proline dipeptidase activity
L2Z44_RS06200	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z44_RS06200	COG1902	pentaerythritol trinitrate reductase activity
L2Z44_RS06240	COG1309	transcriptional regulator
L2Z44_RS06250	COG1335	isochorismatase
L2Z44_RS06255	COG0583	DNA-binding transcription factor activity
L2Z44_RS06265	COG0475	glutathione-regulated potassium exporter activity
L2Z44_RS06265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z44_RS06275	COG1473	amidohydrolase
L2Z44_RS06315	COG2188	Transcriptional regulator
L2Z44_RS06330	COG0583	DNA-binding transcription factor activity
L2Z44_RS06355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z44_RS06370	COG2271	Major facilitator Superfamily
L2Z44_RS06380	COG1566	PFAM secretion protein HlyD family protein
L2Z44_RS06395	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS06400	COG0129	dihydroxy-acid dehydratase activity
L2Z44_RS06410	COG0583	DNA-binding transcription factor activity
L2Z44_RS06415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z44_RS06425	COG2084	Dehydrogenase
L2Z44_RS06430	COG2207	Transcriptional regulator
L2Z44_RS06445	COG1064	alcohol dehydrogenase
L2Z44_RS06455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z44_RS06460	COG1120	ATPase activity
L2Z44_RS06480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z44_RS06610	COG2207	Transcriptional regulator
L2Z44_RS06620	COG2205	protein histidine kinase activity
L2Z44_RS06625	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS06630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS06635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z44_RS06800	COG3539	Fimbrial protein
L2Z44_RS06825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z44_RS06835	COG0753	catalase activity
L2Z44_RS06850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z44_RS06915	COG1535	isochorismatase
L2Z44_RS06915	COG3433	isochorismatase activity
L2Z44_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS06925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z44_RS06930	COG4149	molybdate abc transporter
L2Z44_RS06935	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z44_RS06945	COG4638	Rieske (2fe-2S)
L2Z44_RS06950	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z44_RS06955	COG0543	2 iron, 2 sulfur cluster binding
L2Z44_RS06955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z44_RS06970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS06995	COG2207	Transcriptional regulator
L2Z44_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS07005	COG2610	gluconate transmembrane transporter activity
L2Z44_RS07015	COG1309	transcriptional regulator
L2Z44_RS07035	COG0583	DNA-binding transcription factor activity
L2Z44_RS07050	COG2031	fatty acid transporter
L2Z44_RS07055	COG0183	Belongs to the thiolase family
L2Z44_RS07060	COG0583	DNA-binding transcription factor activity
L2Z44_RS07065	COG0583	DNA-binding transcription factor activity
L2Z44_RS07080	COG1027	Aspartate ammonia-lyase
L2Z44_RS07090	COG0477	Major facilitator Superfamily
L2Z44_RS07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z44_RS07115	COG4521	taurine ABC transporter
L2Z44_RS07130	COG2188	Transcriptional regulator
L2Z44_RS07140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z44_RS07145	COG1733	regulation of RNA biosynthetic process
L2Z44_RS07150	COG3708	Transcriptional regulator
L2Z44_RS07150	COG2207	Transcriptional regulator
L2Z44_RS07165	COG0730	response to heat
L2Z44_RS07180	COG3453	Protein conserved in bacteria
L2Z44_RS07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z44_RS07190	COG3781	membrane
L2Z44_RS07195	COG1063	alcohol dehydrogenase
L2Z44_RS07205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z44_RS07210	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z44_RS07215	COG0022	dehydrogenase e1 component
L2Z44_RS07220	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z44_RS07225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z44_RS07240	COG3706	GGDEF domain
L2Z44_RS07255	COG0133	tryptophan synthase activity
L2Z44_RS07265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z44_RS07300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z44_RS07325	COG2226	methyltransferase
L2Z44_RS07380	COG0842	Transport permease protein
L2Z44_RS07385	COG0842	Transport permease protein
L2Z44_RS07390	COG1131	(ABC) transporter
L2Z44_RS07405	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z44_RS07410	COG4773	Receptor
L2Z44_RS07430	COG0730	response to heat
L2Z44_RS07435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z44_RS07450	COG0406	alpha-ribazole phosphatase activity
L2Z44_RS07455	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z44_RS07470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z44_RS07510	COG4264	IucA IucC family
L2Z44_RS07515	COG4264	IucA IucC family
L2Z44_RS07520	COG2814	Major facilitator Superfamily
L2Z44_RS07535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z44_RS07550	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS07555	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS07560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z44_RS07565	COG2207	Transcriptional regulator
L2Z44_RS07570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z44_RS07575	COG0776	regulation of translation
L2Z44_RS07600	COG0822	iron-sulfur transferase activity
L2Z44_RS07605	COG0316	Belongs to the HesB IscA family
L2Z44_RS07635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z44_RS07655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z44_RS07660	COG0702	epimerase
L2Z44_RS07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z44_RS07705	COG0339	signal peptide processing
L2Z44_RS07750	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z44_RS07755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z44_RS07785	COG0776	regulation of translation
L2Z44_RS07850	COG0084	hydrolase, TatD family'
L2Z44_RS07870	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z44_RS07875	COG1132	(ABC) transporter
L2Z44_RS07885	COG0811	peptide transport
L2Z44_RS07890	COG1475	DNA binding
L2Z44_RS07895	COG1192	Involved in chromosome partitioning
L2Z44_RS07905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z44_RS07920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z44_RS07925	COG0191	fructose-bisphosphate aldolase activity
L2Z44_RS07945	COG0424	maF-like protein
L2Z44_RS07950	COG2850	peptidyl-arginine hydroxylation
L2Z44_RS07960	COG0640	Transcriptional regulator
L2Z44_RS07970	COG3619	membrane
L2Z44_RS07975	COG3122	Protein conserved in bacteria
L2Z44_RS07980	COG1132	(ABC) transporter
L2Z44_RS08000	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z44_RS08005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z44_RS08015	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z44_RS08015	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z44_RS08015	COG0506	proline dehydrogenase activity
L2Z44_RS08020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z44_RS08035	COG3698	Phosphodiester glycosidase
L2Z44_RS08045	COG2353	YceI-like domain
L2Z44_RS08055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z44_RS08100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z44_RS08100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z44_RS08125	COG3539	Fimbrial protein
L2Z44_RS08130	COG3121	Chaperone
L2Z44_RS08155	COG0697	spore germination
L2Z44_RS08165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z44_RS08175	COG0583	DNA-binding transcription factor activity
L2Z44_RS08195	COG1309	transcriptional regulator
L2Z44_RS08210	COG1522	sequence-specific DNA binding
L2Z44_RS08220	COG1126	abc transporter atp-binding protein
L2Z44_RS08225	COG0765	amino acid transport
L2Z44_RS08230	COG0765	amino acid transport
L2Z44_RS08260	COG1464	Belongs to the NlpA lipoprotein family
L2Z44_RS08270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z44_RS08275	COG2011	ABC-type metal ion transport system permease component
L2Z44_RS08280	COG0012	GTP binding
L2Z44_RS08305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z44_RS08345	COG0386	Belongs to the glutathione peroxidase family
L2Z44_RS08355	COG0436	Aminotransferase
L2Z44_RS08360	COG1301	dicarboxylic acid transport
L2Z44_RS08395	COG3634	alkyl hydroperoxide reductase activity
L2Z44_RS08410	COG0583	DNA-binding transcription factor activity
L2Z44_RS08415	COG0798	PFAM Bile acid sodium symporter
L2Z44_RS08420	COG0640	Transcriptional regulator
L2Z44_RS08435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z44_RS08445	COG0583	DNA-binding transcription factor activity
L2Z44_RS08455	COG1953	Uracil, thiamine, allantoin
L2Z44_RS08465	COG2175	clavaminate synthase activity
L2Z44_RS08470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z44_RS08475	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z44_RS08480	COG4521	taurine ABC transporter
L2Z44_RS08490	COG0477	Major facilitator Superfamily
L2Z44_RS08510	COG1271	oxidase subunit
L2Z44_RS08515	COG1294	oxidase, subunit
L2Z44_RS08525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z44_RS08545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z44_RS08565	COG3052	prosthetic group binding
L2Z44_RS08570	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z44_RS08580	COG0583	DNA-binding transcription factor activity
L2Z44_RS08590	COG2814	Major facilitator Superfamily
L2Z44_RS08610	COG1346	cytolysis
L2Z44_RS08620	COG0583	DNA-binding transcription factor activity
L2Z44_RS08625	COG0625	glutathione transferase activity
L2Z44_RS08630	COG0625	glutathione transferase activity
L2Z44_RS08635	COG0583	DNA-binding transcription factor activity
L2Z44_RS08640	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS08650	COG1045	serine acetyltransferase
L2Z44_RS08655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z44_RS08660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z44_RS08670	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS08685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z44_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z44_RS08700	COG0765	amino acid transport
L2Z44_RS08705	COG0765	amino acid transport
L2Z44_RS08725	COG2205	protein histidine kinase activity
L2Z44_RS08725	COG0784	Response regulator, receiver
L2Z44_RS08745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z44_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS08815	COG0583	DNA-binding transcription factor activity
L2Z44_RS08835	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z44_RS08840	COG1309	transcriptional regulator
L2Z44_RS08845	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS08850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z44_RS08855	COG1024	Enoyl-CoA hydratase
L2Z44_RS08860	COG4770	biotin carboxylase activity
L2Z44_RS08870	COG0583	DNA-binding transcription factor activity
L2Z44_RS08885	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS08895	COG2814	Major facilitator Superfamily
L2Z44_RS08905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z44_RS08910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z44_RS08915	COG2814	Major facilitator Superfamily
L2Z44_RS08920	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS08925	COG1024	Enoyl-CoA hydratase
L2Z44_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS08935	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z44_RS08940	COG0183	Belongs to the thiolase family
L2Z44_RS08950	COG2814	Major facilitator Superfamily
L2Z44_RS08960	COG1024	Enoyl-CoA hydratase
L2Z44_RS08975	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS08980	COG2814	Major facilitator Superfamily
L2Z44_RS08985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z44_RS08990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z44_RS09005	COG3842	ATPase activity
L2Z44_RS09010	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z44_RS09020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z44_RS09025	COG1414	Transcriptional regulator
L2Z44_RS09035	COG0583	DNA-binding transcription factor activity
L2Z44_RS09040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z44_RS09045	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS09055	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z44_RS09065	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS09070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z44_RS09075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS09080	COG2267	carboxylic ester hydrolase activity
L2Z44_RS09100	COG3038	cytochrome b561
L2Z44_RS09105	COG0753	catalase activity
L2Z44_RS09145	COG3634	alkyl hydroperoxide reductase activity
L2Z44_RS09150	COG1309	transcriptional regulator
L2Z44_RS09155	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z44_RS09165	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z44_RS09170	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z44_RS09175	COG0183	Belongs to the thiolase family
L2Z44_RS09180	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z44_RS09185	COG1024	Enoyl-CoA hydratase
L2Z44_RS09190	COG1024	Enoyl-CoA hydratase
L2Z44_RS09195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z44_RS09200	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z44_RS09205	COG3396	Phenylacetate-CoA oxygenase
L2Z44_RS09210	COG3460	Phenylacetate-CoA oxygenase
L2Z44_RS09215	COG3396	Phenylacetate-CoA oxygenase
L2Z44_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS09220	COG2030	dehydratase
L2Z44_RS09225	COG1760	l-serine dehydratase
L2Z44_RS09230	COG0531	amino acid
L2Z44_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS09260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z44_RS09280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z44_RS09290	COG0789	Transcriptional regulator
L2Z44_RS09300	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z44_RS09315	COG2807	transmembrane transport
L2Z44_RS09320	COG0590	tRNA wobble adenosine to inosine editing
L2Z44_RS09485	COG1116	anion transmembrane transporter activity
L2Z44_RS09490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z44_RS09500	COG0864	Transcriptional regulator
L2Z44_RS09510	COG1733	regulation of RNA biosynthetic process
L2Z44_RS09515	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z44_RS09520	COG0439	Biotin carboxylase
L2Z44_RS09535	COG1063	alcohol dehydrogenase
L2Z44_RS09545	COG1309	transcriptional regulator
L2Z44_RS09555	COG3210	domain, Protein
L2Z44_RS09560	COG2831	hemolysin activation secretion protein
L2Z44_RS09565	COG0038	chloride channel
L2Z44_RS09570	COG4770	biotin carboxylase activity
L2Z44_RS09590	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z44_RS09595	COG0583	DNA-binding transcription factor activity
L2Z44_RS09715	COG3209	COG3209 Rhs family protein
L2Z44_RS09870	COG3209	COG3209 Rhs family protein
L2Z44_RS09925	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z44_RS09945	COG4521	taurine ABC transporter
L2Z44_RS09950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z44_RS09955	COG1116	anion transmembrane transporter activity
L2Z44_RS09960	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z44_RS09970	COG2814	Major facilitator Superfamily
L2Z44_RS09985	COG1560	Kdo2-lipid A biosynthetic process
L2Z44_RS09995	COG5006	permease, DMT superfamily
L2Z44_RS10000	COG1522	sequence-specific DNA binding
L2Z44_RS10015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z44_RS10025	COG4122	O-methyltransferase activity
L2Z44_RS10055	COG1538	Outer membrane efflux protein
L2Z44_RS10060	COG1137	ATPase activity
L2Z44_RS10065	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z44_RS10075	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z44_RS10120	COG2814	Major facilitator Superfamily
L2Z44_RS10155	COG1278	Cold shock
L2Z44_RS10160	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS10190	COG1570	exodeoxyribonuclease VII activity
L2Z44_RS10240	COG0583	DNA-binding transcription factor activity
L2Z44_RS10250	COG4638	Rieske (2fe-2S)
L2Z44_RS10260	COG0543	2 iron, 2 sulfur cluster binding
L2Z44_RS10260	COG0633	Ferredoxin
L2Z44_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS10270	COG3135	benzoate transporter
L2Z44_RS10275	COG2814	Major facilitator Superfamily
L2Z44_RS10290	COG1643	Atp-dependent helicase
L2Z44_RS10295	COG0450	alkyl hydroperoxide reductase
L2Z44_RS10305	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z44_RS10315	COG3634	alkyl hydroperoxide reductase activity
L2Z44_RS10335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z44_RS10340	COG0625	glutathione transferase activity
L2Z44_RS10350	COG2885	chlorophyll binding
L2Z44_RS10385	COG0542	response to heat
L2Z44_RS10400	COG1765	OsmC-like protein
L2Z44_RS10415	COG0667	Aldo Keto reductase
L2Z44_RS10430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z44_RS10440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z44_RS10450	COG0582	viral genome integration into host DNA
L2Z44_RS10455	COG2194	sulfuric ester hydrolase activity
L2Z44_RS10485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z44_RS10565	COG3566	protein conserved in bacteria
L2Z44_RS10585	COG3567	Phage-associated protein, HI1409 family
L2Z44_RS10590	COG5410	chromosome segregation
L2Z44_RS10765	COG0527	aspartate kinase activity
L2Z44_RS10775	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z44_RS10785	COG3038	cytochrome b561
L2Z44_RS10790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z44_RS10795	COG2252	PERMEase
L2Z44_RS10805	COG2072	flavoprotein involved in K transport
L2Z44_RS10820	COG1741	Belongs to the pirin family
L2Z44_RS10825	COG1309	transcriptional regulator
L2Z44_RS10840	COG2072	flavoprotein involved in K transport
L2Z44_RS10845	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z44_RS10890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z44_RS10905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z44_RS10920	COG2814	Major facilitator Superfamily
L2Z44_RS10925	COG1024	Enoyl-CoA hydratase
L2Z44_RS10930	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS10940	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS10965	COG2186	Transcriptional regulator
L2Z44_RS10970	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS10980	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z44_RS10985	COG2271	Major facilitator Superfamily
L2Z44_RS10990	COG2721	sulfolactate sulfo-lyase activity
L2Z44_RS10995	COG0697	spore germination
L2Z44_RS11015	COG1113	amino acid transport
L2Z44_RS11035	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS11055	COG0531	amino acid
L2Z44_RS11065	COG1113	amino acid transport
L2Z44_RS11130	COG3209	COG3209 Rhs family protein
L2Z44_RS11215	COG0583	DNA-binding transcription factor activity
L2Z44_RS11225	COG0251	oxidation-reduction process
L2Z44_RS11240	COG0457	Tetratricopeptide repeat
L2Z44_RS11250	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z44_RS11250	COG1902	pentaerythritol trinitrate reductase activity
L2Z44_RS11265	COG4251	negative regulation of phosphorylation
L2Z44_RS11265	COG5001	Diguanylate cyclase
L2Z44_RS11265	COG2203	Gaf domain
L2Z44_RS11265	COG3706	GGDEF domain
L2Z44_RS11275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z44_RS11295	COG4172	Belongs to the ABC transporter superfamily
L2Z44_RS11300	COG4239	(ABC) transporter, permease
L2Z44_RS11305	COG4174	ABC transporter (Permease)
L2Z44_RS11315	COG1388	LysM domain
L2Z44_RS11315	COG1388	LysM domain
L2Z44_RS11315	COG0741	lytic transglycosylase activity
L2Z44_RS11315	COG0741	lytic transglycosylase activity
L2Z44_RS11320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z44_RS11375	COG0583	DNA-binding transcription factor activity
L2Z44_RS11380	COG1279	arginine transmembrane transporter activity
L2Z44_RS11400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z44_RS11405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z44_RS11410	COG0006	proline dipeptidase activity
L2Z44_RS11705	COG3620	sequence-specific DNA binding
L2Z44_RS11775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z44_RS11800	COG3384	dioxygenase
L2Z44_RS11810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z44_RS11815	COG2878	Part of a membrane complex involved in electron transport
L2Z44_RS11820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z44_RS11845	COG0768	penicillin binding
L2Z44_RS11850	COG0742	ribosomal rna small subunit methyltransferase
L2Z44_RS11865	COG0830	nickel cation binding
L2Z44_RS11875	COG0804	urea catabolic process
L2Z44_RS11915	COG1253	flavin adenine dinucleotide binding
L2Z44_RS11920	COG2851	Citrate transporter
L2Z44_RS11970	COG1773	rubredoxin
L2Z44_RS11975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z44_RS11985	COG0583	DNA-binding transcription factor activity
L2Z44_RS12015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z44_RS12020	COG4181	ATPase activity
L2Z44_RS12045	COG4771	TonB-dependent receptor
L2Z44_RS12065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z44_RS12085	COG0306	phosphate transporter
L2Z44_RS12095	COG3958	Transketolase
L2Z44_RS12100	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z44_RS12105	COG2271	Major facilitator Superfamily
L2Z44_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS12115	COG0583	DNA-binding transcription factor activity
L2Z44_RS12130	COG2223	nitrite transmembrane transporter activity
L2Z44_RS12135	COG2207	Transcriptional regulator
L2Z44_RS12140	COG2066	Belongs to the glutaminase family
L2Z44_RS12145	COG0242	peptide deformylase activity
L2Z44_RS12150	COG0477	Major facilitator Superfamily
L2Z44_RS12160	COG0028	Belongs to the TPP enzyme family
L2Z44_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS12180	COG2267	carboxylic ester hydrolase activity
L2Z44_RS12190	COG2271	Major facilitator Superfamily
L2Z44_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS12225	COG1414	Transcriptional regulator
L2Z44_RS12240	COG1024	Enoyl-CoA hydratase
L2Z44_RS12250	COG1215	transferase activity, transferring glycosyl groups
L2Z44_RS12255	COG0726	polysaccharide deacetylase
L2Z44_RS12255	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z44_RS12265	COG4681	YaeQ
L2Z44_RS12275	COG0523	cobalamin synthesis protein
L2Z44_RS12285	COG1607	acyl-coa hydrolase
L2Z44_RS12295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z44_RS12300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z44_RS12305	COG1309	transcriptional regulator
L2Z44_RS12330	COG2040	homocysteine
L2Z44_RS12335	COG0531	amino acid
L2Z44_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z44_RS12365	COG0477	Major facilitator Superfamily
L2Z44_RS12375	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L2Z44_RS12500	COG0405	Gamma-glutamyltransferase
L2Z44_RS12505	COG2814	Major facilitator Superfamily
L2Z44_RS12515	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z44_RS12530	COG1090	epimerase
L2Z44_RS12550	COG0420	3'-5' exonuclease activity
L2Z44_RS12575	COG0735	belongs to the Fur family
L2Z44_RS12580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z44_RS12600	COG0121	glutamine amidotransferase
L2Z44_RS12615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z44_RS12625	COG0210	DNA helicase
L2Z44_RS12630	COG2885	chlorophyll binding
L2Z44_RS12635	COG0204	Acyl-transferase
L2Z44_RS12650	COG2894	cell division
L2Z44_RS12665	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS12670	COG1674	ftsk spoiiie
L2Z44_RS12670	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z44_RS12675	COG0492	ferredoxin-NADP+ reductase activity
L2Z44_RS12680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z44_RS12690	COG0456	acetyltransferase
L2Z44_RS12735	COG1981	membrane
L2Z44_RS12750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z44_RS12750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z44_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS12780	COG0657	acetylesterase activity
L2Z44_RS12790	COG0473	3-isopropylmalate dehydrogenase activity
L2Z44_RS12795	COG0583	DNA-binding transcription factor activity
L2Z44_RS12815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z44_RS12840	COG0564	pseudouridine synthase activity
L2Z44_RS12850	COG0358	DNA primase activity
L2Z44_RS12865	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z44_RS12895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z44_RS12925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z44_RS12935	COG0351	phosphomethylpyrimidine kinase
L2Z44_RS12935	COG0352	thiamine-phosphate diphosphorylase activity
L2Z44_RS12935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z44_RS12940	COG1652	LysM domain
L2Z44_RS12965	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z44_RS12970	COG3101	peptidyl-lysine hydroxylation
L2Z44_RS12975	COG0009	L-threonylcarbamoyladenylate synthase
L2Z44_RS12980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z44_RS12985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z44_RS13000	COG4106	trans-aconitate 2-methyltransferase activity
L2Z44_RS13015	COG0596	Alpha beta hydrolase
L2Z44_RS13015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z44_RS13015	COG2226	methyltransferase
L2Z44_RS13020	COG1877	trehalose-phosphatase activity
L2Z44_RS13025	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z44_RS13030	COG2223	nitrite transmembrane transporter activity
L2Z44_RS13050	COG1196	nuclear chromosome segregation
L2Z44_RS13060	COG0730	response to heat
L2Z44_RS13075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z44_RS13085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z44_RS13140	COG0489	protein tyrosine kinase activity
L2Z44_RS13150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z44_RS13150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z44_RS13180	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z44_RS13185	COG2081	HI0933 family
L2Z44_RS13195	COG0668	transmembrane transport
L2Z44_RS13215	COG0583	DNA-binding transcription factor activity
L2Z44_RS13235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z44_RS13240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z44_RS13270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z44_RS13310	COG0745	RESPONSE REGULATOR receiver
L2Z44_RS13330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z44_RS13355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS13370	COG0583	DNA-binding transcription factor activity
L2Z44_RS13380	COG0583	DNA-binding transcription factor activity
L2Z44_RS13395	COG0583	DNA-binding transcription factor activity
L2Z44_RS13400	COG1053	succinate dehydrogenase
L2Z44_RS13410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z44_RS13415	COG2814	Major facilitator Superfamily
L2Z44_RS13420	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS13425	COG0583	DNA-binding transcription factor activity
L2Z44_RS13430	COG1063	alcohol dehydrogenase
L2Z44_RS13465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z44_RS13470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z44_RS13475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z44_RS13495	COG2132	Multicopper oxidase
L2Z44_RS13505	COG0561	phosphatase activity
L2Z44_RS13510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z44_RS13535	COG1214	PFAM Peptidase M22, glycoprotease
L2Z44_RS13585	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z44_RS13595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z44_RS13600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z44_RS13605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z44_RS13665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z44_RS13675	COG1846	Transcriptional regulator
L2Z44_RS13680	COG1764	response to oxidative stress
L2Z44_RS13720	COG0037	tRNA processing
L2Z44_RS13730	COG0248	Ppx GppA phosphatase
L2Z44_RS13760	COG0072	phenylalanine-tRNA ligase activity
L2Z44_RS13805	COG1238	metal cluster binding
L2Z44_RS13810	COG0625	glutathione transferase activity
L2Z44_RS13825	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z44_RS13830	COG3028	Belongs to the UPF0307 family
L2Z44_RS13835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z44_RS13855	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z44_RS13860	COG0617	tRNA 3'-terminal CCA addition
L2Z44_RS13865	COG1555	photosystem II stabilization
L2Z44_RS13870	COG3956	TIGRFAM MazG family protein
L2Z44_RS13880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z44_RS13900	COG0784	Response regulator, receiver
L2Z44_RS13900	COG2205	protein histidine kinase activity
L2Z44_RS13900	COG5002	protein histidine kinase activity
L2Z44_RS13905	COG1024	Enoyl-CoA hydratase
L2Z44_RS13910	COG2084	Dehydrogenase
L2Z44_RS13915	COG3622	Belongs to the hyi family
L2Z44_RS13945	COG0697	spore germination
L2Z44_RS13955	COG2814	Major facilitator Superfamily
L2Z44_RS13965	COG0492	ferredoxin-NADP+ reductase activity
L2Z44_RS13970	COG0431	NADPH-dependent FMN reductase
L2Z44_RS13975	COG0798	PFAM Bile acid sodium symporter
L2Z44_RS13985	COG0640	Transcriptional regulator
L2Z44_RS14020	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z44_RS14045	COG2132	Multicopper oxidase
L2Z44_RS14060	COG2205	protein histidine kinase activity
L2Z44_RS14145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z44_RS14155	COG0583	DNA-binding transcription factor activity
L2Z44_RS14165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z44_RS14175	COG0084	hydrolase, TatD family'
L2Z44_RS14190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z44_RS14230	COG0440	acetolactate synthase activity
L2Z44_RS14235	COG0028	Belongs to the TPP enzyme family
L2Z44_RS14260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS14265	COG0577	efflux transmembrane transporter activity
L2Z44_RS14265	COG1136	(ABC) transporter
L2Z44_RS14270	COG1538	Outer membrane efflux protein
L2Z44_RS14285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z44_RS14290	COG1162	GTPase activity
L2Z44_RS14300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z44_RS14340	COG1426	Protein conserved in bacteria
L2Z44_RS14375	COG0793	Belongs to the peptidase S41A family
L2Z44_RS14390	COG2267	carboxylic ester hydrolase activity
L2Z44_RS14400	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS14405	COG3265	gluconokinase activity
L2Z44_RS14415	COG0800	Aldolase
L2Z44_RS14425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z44_RS14430	COG0280	phosphate acetyltransferase
L2Z44_RS14430	COG0857	belongs to the CobB CobQ family
L2Z44_RS14435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z44_RS14435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z44_RS14455	COG0740	serine-type endopeptidase activity
L2Z44_RS14465	COG4774	siderophore transport
L2Z44_RS14475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z44_RS14485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z44_RS14485	COG2813	Specifically methylates the guanine in position
L2Z44_RS14585	COG0788	formyltetrahydrofolate deformylase activity
L2Z44_RS14610	COG4651	solute:proton antiporter activity
L2Z44_RS14610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z44_RS14630	COG0724	RNA recognition motif
L2Z44_RS14635	COG0210	DNA helicase
L2Z44_RS14660	COG1733	regulation of RNA biosynthetic process
L2Z44_RS14670	COG2900	Belongs to the SlyX family
L2Z44_RS14675	COG0488	(ABC) transporter
L2Z44_RS14685	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS14690	COG1560	Kdo2-lipid A biosynthetic process
L2Z44_RS14700	COG1301	dicarboxylic acid transport
L2Z44_RS14755	COG0473	3-isopropylmalate dehydrogenase activity
L2Z44_RS14810	COG0583	DNA-binding transcription factor activity
L2Z44_RS14820	COG0625	glutathione transferase activity
L2Z44_RS14825	COG2378	regulation of single-species biofilm formation
L2Z44_RS14830	COG0546	phosphoglycolate phosphatase activity
L2Z44_RS14840	COG1530	ribonuclease E activity
L2Z44_RS14845	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z44_RS14860	COG0583	DNA-binding transcription factor activity
L2Z44_RS14865	COG4221	oxidoreductase activity
L2Z44_RS14870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z44_RS14880	COG0534	Mate efflux family protein
L2Z44_RS14895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z44_RS14920	COG0493	'glutamate synthase
L2Z44_RS14920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z44_RS14930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z44_RS14935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z44_RS14950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z44_RS14960	COG0644	oxidoreductase
L2Z44_RS14960	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z44_RS14970	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z44_RS14975	COG4535	Mg2 and Co2 transporter CorC
L2Z44_RS14985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z44_RS15005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z44_RS15010	COG0475	glutathione-regulated potassium exporter activity
L2Z44_RS15010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z44_RS15025	COG0484	heat shock protein binding
L2Z44_RS15030	COG0789	Transcriptional regulator
L2Z44_RS15035	COG0598	Magnesium transport protein CorA
L2Z44_RS15050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z44_RS15055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z44_RS15060	COG1074	ATP-dependent DNA helicase activity
L2Z44_RS15065	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z44_RS15085	COG2226	methyltransferase
L2Z44_RS15105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z44_RS15120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z44_RS15120	COG2111	Na H antiporter
L2Z44_RS15125	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z44_RS15130	COG0651	ATP synthesis coupled electron transport
L2Z44_RS15135	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z44_RS15140	COG2212	antiporter activity
L2Z44_RS15145	COG1320	monovalent cation:proton antiporter activity
L2Z44_RS15160	COG0195	Participates in both transcription termination and antitermination
L2Z44_RS15210	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z44_RS15215	COG0237	dephospho-CoA kinase activity
L2Z44_RS15225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z44_RS15240	COG0497	DNA recombination
L2Z44_RS15250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z44_RS15280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z44_RS15280	COG2169	Transcriptional regulator
L2Z44_RS15285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z44_RS15350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z44_RS15365	COG0326	Molecular chaperone. Has ATPase activity
L2Z44_RS15380	COG2056	Na+-H+ antiporter family
L2Z44_RS15385	COG0596	Alpha beta hydrolase
L2Z44_RS15480	COG0546	phosphoglycolate phosphatase activity
L2Z44_RS15485	COG1716	ATPase activity
L2Z44_RS15530	COG0181	hydroxymethylbilane synthase activity
L2Z44_RS15540	COG3275	phosphorelay sensor kinase activity
L2Z44_RS15560	COG1538	Outer membrane efflux protein
L2Z44_RS15565	COG0697	spore germination
L2Z44_RS15590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z44_RS15595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z44_RS15600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z44_RS15605	COG0772	Belongs to the SEDS family
L2Z44_RS15630	COG4974	Belongs to the 'phage' integrase family
L2Z44_RS15635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z44_RS15645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z44_RS15655	COG2197	response regulator
L2Z44_RS15670	COG0793	Belongs to the peptidase S41A family
L2Z44_RS15675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z44_RS15680	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z44_RS15720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z44_RS15720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z44_RS15730	COG0004	ammonium transporteR
L2Z44_RS15735	COG0347	Belongs to the P(II) protein family
L2Z44_RS15745	COG0606	chelatase, subunit chli
L2Z44_RS15755	COG0235	Class ii aldolase
L2Z44_RS15760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z44_RS15780	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z44_RS15795	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z44_RS15805	COG0477	Major facilitator Superfamily
L2Z44_RS15810	COG2860	membrane
L2Z44_RS15815	COG3012	SEC-C Motif Domain Protein
L2Z44_RS15820	COG1253	flavin adenine dinucleotide binding
L2Z44_RS15830	COG0477	Major facilitator Superfamily
L2Z44_RS15840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z44_RS15880	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z44_RS15890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z44_RS15960	COG0758	DNA mediated transformation
L2Z44_RS15970	COG0697	spore germination
L2Z44_RS15975	COG1309	transcriptional regulator
L2Z44_RS15990	COG0386	Belongs to the glutathione peroxidase family
L2Z44_RS16055	COG1121	(ABC) transporter
L2Z44_RS16060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z44_RS16065	COG1280	lysine exporter protein (LysE YggA)
L2Z44_RS16070	COG2837	iron assimilation
L2Z44_RS16080	COG0281	malic enzyme
L2Z44_RS16125	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z44_RS16125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z44_RS16130	COG4399	Belongs to the UPF0754 family
L2Z44_RS16135	COG2259	Doxx family
L2Z44_RS16140	COG0586	Pfam SNARE associated Golgi protein
L2Z44_RS16155	COG1192	Involved in chromosome partitioning
L2Z44_RS16165	COG0271	Belongs to the BolA IbaG family
L2Z44_RS16205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z44_RS16205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z44_RS16205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z44_RS16205	COG3321	synthase
L2Z44_RS16210	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS16220	COG2197	response regulator
L2Z44_RS16230	COG3916	Acyl-homoserine-lactone synthase
L2Z44_RS16235	COG0477	Major facilitator Superfamily
L2Z44_RS16240	COG1024	Enoyl-CoA hydratase
L2Z44_RS16245	COG1024	Enoyl-CoA hydratase
L2Z44_RS16250	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS16255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z44_RS16275	COG1113	amino acid transport
L2Z44_RS16280	COG1113	amino acid transport
L2Z44_RS16285	COG0251	oxidation-reduction process
L2Z44_RS16325	COG0564	pseudouridine synthase activity
L2Z44_RS16445	COG1051	belongs to the nudix hydrolase family
L2Z44_RS16465	COG1403	HNH endonuclease
L2Z44_RS16470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z44_RS16485	COG1802	Transcriptional regulator
L2Z44_RS16495	COG1448	Aminotransferase
L2Z44_RS16500	COG0277	FAD linked oxidase domain protein
L2Z44_RS16510	COG2186	Transcriptional regulator
L2Z44_RS16520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z44_RS16530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z44_RS16545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z44_RS16550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z44_RS16560	COG0438	transferase activity, transferring glycosyl groups
L2Z44_RS16570	COG0438	transferase activity, transferring glycosyl groups
L2Z44_RS16575	COG1215	transferase activity, transferring glycosyl groups
L2Z44_RS16585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z44_RS16615	COG0728	peptidoglycan biosynthetic process
L2Z44_RS16620	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z44_RS16680	COG0546	phosphoglycolate phosphatase activity
L2Z44_RS16685	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z44_RS16705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z44_RS16710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z44_RS16715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z44_RS16720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z44_RS16725	COG1116	anion transmembrane transporter activity
L2Z44_RS16730	COG1309	transcriptional regulator
L2Z44_RS16735	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z44_RS16745	COG0196	riboflavin kinase activity
L2Z44_RS16750	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z44_RS16760	COG1047	Peptidyl-prolyl cis-trans
L2Z44_RS16800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z44_RS16805	COG0657	acetylesterase activity
L2Z44_RS16825	COG0583	DNA-binding transcription factor activity
L2Z44_RS16855	COG2951	lytic endotransglycosylase activity
L2Z44_RS16860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z44_RS16875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z44_RS16885	COG0671	phosphoesterase, PA-phosphatase related
L2Z44_RS16890	COG0861	Integral membrane protein TerC family
L2Z44_RS16900	COG0754	glutathionylspermidine amidase activity
L2Z44_RS16910	COG0402	S-adenosylhomocysteine deaminase activity
L2Z44_RS16925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z44_RS16930	COG1230	cation diffusion facilitator family transporter
L2Z44_RS16945	COG0706	membrane insertase activity
L2Z44_RS16970	COG0592	DNA-directed DNA polymerase activity
L2Z44_RS16980	COG0187	DNA topoisomerase II activity
L2Z44_RS16990	COG0586	Pfam SNARE associated Golgi protein
L2Z44_RS16995	COG0488	(ABC) transporter
L2Z44_RS17020	COG0596	Alpha beta hydrolase
L2Z44_RS17025	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z44_RS17030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z44_RS17070	COG0733	neurotransmitter:sodium symporter activity
L2Z44_RS17105	COG0583	DNA-binding transcription factor activity
L2Z44_RS17110	COG2233	PERMEase
L2Z44_RS17125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z44_RS17160	COG2814	Major facilitator Superfamily
L2Z44_RS17165	COG0656	L-ascorbic acid biosynthetic process
L2Z44_RS17170	COG0583	DNA-binding transcription factor activity
L2Z44_RS17185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z44_RS17190	COG1064	alcohol dehydrogenase
L2Z44_RS17195	COG2818	Glycosylase
L2Z44_RS17210	COG1194	a g-specific adenine glycosylase
L2Z44_RS17230	COG2983	Belongs to the UPF0260 family
L2Z44_RS17235	COG2133	pyrroloquinoline quinone binding
L2Z44_RS17240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z44_RS17245	COG2116	formate transmembrane transporter activity
L2Z44_RS17265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z44_RS17270	COG1335	isochorismatase
L2Z44_RS17275	COG0385	Bile acid
L2Z44_RS17280	COG0534	Mate efflux family protein
L2Z44_RS17285	COG1683	Conserved Protein
L2Z44_RS17305	COG0625	glutathione transferase activity
L2Z44_RS17315	COG1113	amino acid transport
L2Z44_RS17325	COG0523	cobalamin synthesis protein
L2Z44_RS17335	COG2188	Transcriptional regulator
L2Z44_RS17365	COG0010	Belongs to the arginase family
L2Z44_RS17380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z44_RS17385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z44_RS17395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z44_RS17400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z44_RS17485	COG0534	Mate efflux family protein
L2Z44_RS17490	COG0436	Aminotransferase
L2Z44_RS17495	COG2733	membrane
L2Z44_RS17510	COG2918	glutathione biosynthetic process
L2Z44_RS17620	COG3150	esterase
L2Z44_RS17630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z44_RS17640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z44_RS17650	COG2233	PERMEase
L2Z44_RS17655	COG2351	hydroxyisourate hydrolase activity
L2Z44_RS17690	COG3706	GGDEF domain
L2Z44_RS17705	COG1393	Belongs to the ArsC family
L2Z44_RS17710	COG0708	Exodeoxyribonuclease III
L2Z44_RS17735	COG0189	ligase activity
L2Z44_RS17755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z44_RS17765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z44_RS17780	COG4942	peptidase
L2Z44_RS17790	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z44_RS17800	COG2119	membrane
L2Z44_RS17805	COG4774	siderophore transport
L2Z44_RS17810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z44_RS17810	COG0426	domain, Protein
L2Z44_RS17835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z44_RS17855	COG1902	pentaerythritol trinitrate reductase activity
L2Z44_RS17860	COG1519	Transferase
L2Z44_RS17865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z44_RS17870	COG0668	transmembrane transport
L2Z44_RS17880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z44_RS17885	COG1335	isochorismatase
L2Z44_RS17890	COG1522	sequence-specific DNA binding
L2Z44_RS17915	COG0784	Response regulator, receiver
L2Z44_RS17915	COG2205	protein histidine kinase activity
L2Z44_RS17915	COG2198	Histidine kinase
L2Z44_RS17920	COG3162	membrane
L2Z44_RS17925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z44_RS17935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z44_RS17950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z44_RS17955	COG1309	transcriptional regulator
L2Z44_RS17975	COG0351	phosphomethylpyrimidine kinase
L2Z44_RS17975	COG0352	thiamine-phosphate diphosphorylase activity
L2Z44_RS17975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z44_RS17985	COG2814	Major facilitator Superfamily
L2Z44_RS18035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z44_RS18045	COG1113	amino acid transport
L2Z44_RS18055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z44_RS18060	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS18070	COG1335	isochorismatase
L2Z44_RS18100	COG2814	Major facilitator Superfamily
L2Z44_RS18105	COG0583	DNA-binding transcription factor activity
L2Z44_RS18125	COG0667	Aldo Keto reductase
L2Z44_RS18145	COG1733	regulation of RNA biosynthetic process
L2Z44_RS18175	COG1733	regulation of RNA biosynthetic process
L2Z44_RS18180	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z44_RS18245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z44_RS18260	COG2329	Antibiotic biosynthesis monooxygenase
L2Z44_RS18275	COG1132	(ABC) transporter
L2Z44_RS18295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z44_RS18325	COG0427	acetyl-CoA hydrolase
L2Z44_RS18350	COG0659	secondary active sulfate transmembrane transporter activity
L2Z44_RS18355	COG4221	oxidoreductase activity
L2Z44_RS18360	COG2873	o-acetylhomoserine
L2Z44_RS18365	COG0488	(ABC) transporter
L2Z44_RS18450	COG0833	amino acid
L2Z44_RS18495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z44_RS18500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z44_RS18515	COG2226	methyltransferase
L2Z44_RS18565	COG0067	glutamate synthase
L2Z44_RS18565	COG0069	glutamate synthase activity
L2Z44_RS18565	COG0070	glutamate synthase
L2Z44_RS18570	COG0493	'glutamate synthase
L2Z44_RS18580	COG1704	LemA family
L2Z44_RS18585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z44_RS18595	COG4969	Belongs to the N-Me-Phe pilin family
L2Z44_RS18605	COG3307	-O-antigen
L2Z44_RS18625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z44_RS18640	COG0194	GDP metabolic process
L2Z44_RS18690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z44_RS18710	COG5380	lipid catabolic process
L2Z44_RS18715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z44_RS18740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z44_RS18745	COG0277	FAD linked oxidase domain protein
L2Z44_RS18755	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z44_RS18760	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z44_RS18775	COG1289	transmembrane transporter activity
L2Z44_RS18785	COG0628	permease
L2Z44_RS18790	COG1192	Involved in chromosome partitioning
L2Z44_RS18820	COG0833	amino acid
L2Z44_RS18825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z44_RS18830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z44_RS18840	COG1012	belongs to the aldehyde dehydrogenase family
L2Z44_RS18880	COG0583	DNA-binding transcription factor activity
L2Z44_RS18935	COG0517	IMP dehydrogenase activity
L2Z44_RS18940	COG1983	PspC domain protein
L2Z44_RS18950	COG1960	acyl-CoA dehydrogenase activity
L2Z44_RS18965	COG0408	coproporphyrinogen oxidase activity
L2Z44_RS18985	COG0513	Belongs to the DEAD box helicase family
L2Z44_RS18995	COG1127	ABC transporter
L2Z44_RS19000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z44_RS19010	COG2854	intermembrane phospholipid transfer
L2Z44_RS19020	COG0598	Magnesium transport protein CorA
L2Z44_RS19030	COG0494	nUDIX hydrolase
L2Z44_RS19035	COG1040	competence protein
L2Z44_RS19040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z44_RS19060	COG1946	Acyl-CoA thioesterase
L2Z44_RS19065	COG1301	dicarboxylic acid transport
L2Z44_RS19080	COG1959	2 iron, 2 sulfur cluster binding
L2Z44_RS19085	COG1017	nitric oxide dioxygenase activity
L2Z44_RS19085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z44_RS19095	COG0433	COG0433 Predicted ATPase
L2Z44_RS19100	COG0626	cystathionine gamma-synthase activity