locus-tag	class	description
HFD83_RS00010	COG0592	DNA-directed DNA polymerase activity
HFD83_RS00020	COG0187	DNA topoisomerase II activity
HFD83_RS00030	COG0586	Pfam SNARE associated Golgi protein
HFD83_RS00035	COG0488	(ABC) transporter
HFD83_RS00060	COG0596	Alpha beta hydrolase
HFD83_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HFD83_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFD83_RS00115	COG0733	neurotransmitter:sodium symporter activity
HFD83_RS00155	COG2233	PERMEase
HFD83_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS00205	COG2814	Major facilitator Superfamily
HFD83_RS00210	COG0656	L-ascorbic acid biosynthetic process
HFD83_RS00215	COG0583	DNA-binding transcription factor activity
HFD83_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD83_RS00235	COG1064	alcohol dehydrogenase
HFD83_RS00240	COG2818	Glycosylase
HFD83_RS00255	COG1194	a g-specific adenine glycosylase
HFD83_RS00275	COG2983	Belongs to the UPF0260 family
HFD83_RS00280	COG2133	pyrroloquinoline quinone binding
HFD83_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HFD83_RS00290	COG2116	formate transmembrane transporter activity
HFD83_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD83_RS00315	COG1335	isochorismatase
HFD83_RS00320	COG0385	Bile acid
HFD83_RS00325	COG0534	Mate efflux family protein
HFD83_RS00330	COG1683	Conserved Protein
HFD83_RS00350	COG0625	glutathione transferase activity
HFD83_RS00360	COG1113	amino acid transport
HFD83_RS00370	COG0523	cobalamin synthesis protein
HFD83_RS00380	COG2188	Transcriptional regulator
HFD83_RS00410	COG0010	Belongs to the arginase family
HFD83_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD83_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFD83_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HFD83_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HFD83_RS00545	COG0534	Mate efflux family protein
HFD83_RS00550	COG0436	Aminotransferase
HFD83_RS00555	COG2733	membrane
HFD83_RS00570	COG2918	glutathione biosynthetic process
HFD83_RS00580	COG3501	Rhs element vgr protein
HFD83_RS00585	COG0791	NLP P60 protein
HFD83_RS00585	COG1388	LysM domain
HFD83_RS00600	COG3150	esterase
HFD83_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HFD83_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD83_RS00635	COG2233	PERMEase
HFD83_RS00640	COG2351	hydroxyisourate hydrolase activity
HFD83_RS00675	COG3706	GGDEF domain
HFD83_RS00690	COG1393	Belongs to the ArsC family
HFD83_RS00695	COG0708	Exodeoxyribonuclease III
HFD83_RS00715	COG0189	ligase activity
HFD83_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFD83_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFD83_RS00760	COG4942	peptidase
HFD83_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD83_RS00780	COG2119	membrane
HFD83_RS00790	COG2433	Pfam Transposase IS66
HFD83_RS00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD83_RS00810	COG0426	domain, Protein
HFD83_RS00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HFD83_RS00855	COG1902	pentaerythritol trinitrate reductase activity
HFD83_RS00860	COG1519	Transferase
HFD83_RS00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD83_RS00870	COG0668	transmembrane transport
HFD83_RS00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD83_RS00885	COG1335	isochorismatase
HFD83_RS00890	COG1522	sequence-specific DNA binding
HFD83_RS00895	COG3328	transposase activity
HFD83_RS00920	COG0784	Response regulator, receiver
HFD83_RS00920	COG2198	Histidine kinase
HFD83_RS00920	COG2205	protein histidine kinase activity
HFD83_RS00925	COG3162	membrane
HFD83_RS00930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD83_RS00940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD83_RS00950	COG3706	GGDEF domain
HFD83_RS00960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFD83_RS00965	COG1309	transcriptional regulator
HFD83_RS00985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD83_RS00985	COG0351	phosphomethylpyrimidine kinase
HFD83_RS00985	COG0352	thiamine-phosphate diphosphorylase activity
HFD83_RS00995	COG2814	Major facilitator Superfamily
HFD83_RS01010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD83_RS01020	COG1113	amino acid transport
HFD83_RS01030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD83_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS01045	COG1335	isochorismatase
HFD83_RS01060	COG1061	Type III restriction enzyme res subunit
HFD83_RS01070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD83_RS01075	COG1192	Involved in chromosome partitioning
HFD83_RS01085	COG1061	Type III restriction enzyme res subunit
HFD83_RS01125	COG2814	Major facilitator Superfamily
HFD83_RS01130	COG0583	DNA-binding transcription factor activity
HFD83_RS01150	COG0667	Aldo Keto reductase
HFD83_RS01180	COG1733	regulation of RNA biosynthetic process
HFD83_RS01185	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD83_RS01250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HFD83_RS01265	COG2329	Antibiotic biosynthesis monooxygenase
HFD83_RS01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFD83_RS01325	COG0427	acetyl-CoA hydrolase
HFD83_RS01340	COG0745	RESPONSE REGULATOR receiver
HFD83_RS01350	COG0659	secondary active sulfate transmembrane transporter activity
HFD83_RS01355	COG4221	oxidoreductase activity
HFD83_RS01360	COG2873	o-acetylhomoserine
HFD83_RS01365	COG0488	(ABC) transporter
HFD83_RS01450	COG0833	amino acid
HFD83_RS01495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HFD83_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HFD83_RS01515	COG2226	methyltransferase
HFD83_RS01565	COG0070	glutamate synthase
HFD83_RS01565	COG0069	glutamate synthase activity
HFD83_RS01565	COG0067	glutamate synthase
HFD83_RS01570	COG0493	'glutamate synthase
HFD83_RS01580	COG1704	LemA family
HFD83_RS01585	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFD83_RS01605	COG3307	-O-antigen
HFD83_RS01625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD83_RS01640	COG0194	GDP metabolic process
HFD83_RS01690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFD83_RS01710	COG5380	lipid catabolic process
HFD83_RS01715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFD83_RS01740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFD83_RS01745	COG0277	FAD linked oxidase domain protein
HFD83_RS01755	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFD83_RS01760	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD83_RS01775	COG1289	transmembrane transporter activity
HFD83_RS01785	COG0628	permease
HFD83_RS01790	COG1192	Involved in chromosome partitioning
HFD83_RS01820	COG0833	amino acid
HFD83_RS01825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD83_RS01830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD83_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS01880	COG0583	DNA-binding transcription factor activity
HFD83_RS01925	COG0517	IMP dehydrogenase activity
HFD83_RS01930	COG1983	PspC domain protein
HFD83_RS01940	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS01955	COG0408	coproporphyrinogen oxidase activity
HFD83_RS01975	COG0513	Belongs to the DEAD box helicase family
HFD83_RS01985	COG1127	ABC transporter
HFD83_RS01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFD83_RS02000	COG2854	intermembrane phospholipid transfer
HFD83_RS02010	COG0598	Magnesium transport protein CorA
HFD83_RS02020	COG0494	nUDIX hydrolase
HFD83_RS02025	COG1040	competence protein
HFD83_RS02030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFD83_RS02050	COG1946	Acyl-CoA thioesterase
HFD83_RS02055	COG1301	dicarboxylic acid transport
HFD83_RS02070	COG1959	2 iron, 2 sulfur cluster binding
HFD83_RS02075	COG1017	nitric oxide dioxygenase activity
HFD83_RS02075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD83_RS02080	COG0433	COG0433 Predicted ATPase
HFD83_RS02085	COG0626	cystathionine gamma-synthase activity
HFD83_RS02240	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS02245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HFD83_RS02275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HFD83_RS02280	COG0339	signal peptide processing
HFD83_RS02285	COG0557	exoribonuclease II activity
HFD83_RS02330	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFD83_RS02335	COG2169	Transcriptional regulator
HFD83_RS02340	COG0697	spore germination
HFD83_RS02345	COG1295	ribonuclease BN
HFD83_RS02380	COG1702	phosphate starvation-inducible protein PhoH
HFD83_RS02390	COG1196	nuclear chromosome segregation
HFD83_RS02390	COG0741	lytic transglycosylase activity
HFD83_RS02390	COG0739	heme binding
HFD83_RS02420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HFD83_RS02425	COG1183	phosphatidylcholine synthase activity
HFD83_RS02470	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS02475	COG1309	transcriptional regulator
HFD83_RS02490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD83_RS02495	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS02515	COG2969	positive regulation of protein catabolic process
HFD83_RS02525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFD83_RS02540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFD83_RS02545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HFD83_RS02565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFD83_RS02575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD83_RS02580	COG1408	metallophosphoesterase
HFD83_RS02590	COG2199	diguanylate cyclase activity
HFD83_RS02650	COG1607	acyl-coa hydrolase
HFD83_RS02680	COG2350	Protein conserved in bacteria
HFD83_RS02690	COG0613	PHP domain protein
HFD83_RS02695	COG3781	membrane
HFD83_RS02705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HFD83_RS02710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFD83_RS02720	COG1862	Preprotein translocase
HFD83_RS02765	COG2205	protein histidine kinase activity
HFD83_RS02770	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HFD83_RS02790	COG0726	polysaccharide deacetylase
HFD83_RS02795	COG0463	Glycosyl transferase, family 2
HFD83_RS02800	COG0438	transferase activity, transferring glycosyl groups
HFD83_RS02865	COG0625	glutathione transferase activity
HFD83_RS02870	COG0583	DNA-binding transcription factor activity
HFD83_RS02875	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS02880	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS02890	COG2205	protein histidine kinase activity
HFD83_RS02895	COG0745	RESPONSE REGULATOR receiver
HFD83_RS02900	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFD83_RS02920	COG2096	Adenosyltransferase
HFD83_RS02970	COG0285	dihydrofolate synthase activity
HFD83_RS02990	COG0450	alkyl hydroperoxide reductase
HFD83_RS03005	COG0477	Major facilitator Superfamily
HFD83_RS03010	COG1272	protein, Hemolysin III
HFD83_RS03045	COG0183	Belongs to the thiolase family
HFD83_RS03050	COG2207	Transcriptional regulator
HFD83_RS03070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD83_RS03090	COG0183	Belongs to the thiolase family
HFD83_RS03100	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HFD83_RS03100	COG2885	chlorophyll binding
HFD83_RS03110	COG1690	Belongs to the RtcB family
HFD83_RS03115	COG0833	amino acid
HFD83_RS03125	COG2233	PERMEase
HFD83_RS03155	COG2094	Belongs to the DNA glycosylase MPG family
HFD83_RS03160	COG4772	TonB-dependent receptor
HFD83_RS03175	COG1902	pentaerythritol trinitrate reductase activity
HFD83_RS03180	COG0679	Auxin Efflux Carrier
HFD83_RS03190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD83_RS03195	COG0354	folic acid binding
HFD83_RS03205	COG3189	MarR family transcriptional regulator
HFD83_RS03210	COG2824	Alkylphosphonate utilization operon protein PhnA
HFD83_RS03215	COG3422	double-strand break repair
HFD83_RS03255	COG0840	transmembrane signaling receptor activity
HFD83_RS03275	COG5510	response to toxic substance
HFD83_RS03285	COG2832	Protein of unknown function (DUF454)
HFD83_RS03290	COG1376	ErfK ybiS ycfS ynhG family protein
HFD83_RS03330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HFD83_RS03340	COG1289	transmembrane transporter activity
HFD83_RS03345	COG2814	Major facilitator Superfamily
HFD83_RS03365	COG1115	amino acid carrier protein
HFD83_RS03370	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD83_RS03375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD83_RS03380	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HFD83_RS03410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD83_RS03420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFD83_RS03425	COG1077	Cell shape determining protein MreB Mrl
HFD83_RS03430	COG1792	Involved in formation and maintenance of cell shape
HFD83_RS03435	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HFD83_RS03440	COG0424	maF-like protein
HFD83_RS03445	COG1530	ribonuclease E activity
HFD83_RS03455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD83_RS03465	COG0560	Phosphoserine phosphatase
HFD83_RS03475	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD83_RS03500	COG2207	Transcriptional regulator
HFD83_RS03520	COG1113	amino acid transport
HFD83_RS03525	COG2828	Protein conserved in bacteria
HFD83_RS03530	COG0142	geranyltranstransferase activity
HFD83_RS03535	COG2315	Protein conserved in bacteria
HFD83_RS03550	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFD83_RS03570	COG2194	sulfuric ester hydrolase activity
HFD83_RS03575	COG0745	RESPONSE REGULATOR receiver
HFD83_RS03580	COG0642	Histidine kinase
HFD83_RS03590	COG0004	ammonium transporteR
HFD83_RS03595	COG0583	DNA-binding transcription factor activity
HFD83_RS03615	COG0525	valine-tRNA ligase activity
HFD83_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS03635	COG0393	Putative heavy-metal-binding
HFD83_RS03640	COG0393	Putative heavy-metal-binding
HFD83_RS03645	COG1538	Outer membrane efflux protein
HFD83_RS03655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS03660	COG0671	phosphoesterase, PA-phosphatase related
HFD83_RS03690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HFD83_RS03705	COG1648	precorrin-2 dehydrogenase activity
HFD83_RS03705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFD83_RS03710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFD83_RS03715	COG1733	regulation of RNA biosynthetic process
HFD83_RS03725	COG0531	amino acid
HFD83_RS03740	COG0321	lipoyl(octanoyl) transferase activity
HFD83_RS03745	COG2921	Belongs to the UPF0250 family
HFD83_RS03785	COG2009	succinate dehydrogenase
HFD83_RS03790	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HFD83_RS03795	COG1053	succinate dehydrogenase
HFD83_RS03800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFD83_RS03825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD83_RS03845	COG2354	Protein conserved in bacteria
HFD83_RS03850	COG2321	neutral zinc metallopeptidase
HFD83_RS03890	COG2843	Capsule synthesis protein
HFD83_RS03905	COG0589	response to stress
HFD83_RS03925	COG0505	Belongs to the CarA family
HFD83_RS03950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD83_RS03955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFD83_RS04005	COG0477	Major facilitator Superfamily
HFD83_RS04010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFD83_RS04025	COG1597	lipid kinase activity
HFD83_RS04030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD83_RS04055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD83_RS04060	COG0584	glycerophosphoryl diester phosphodiesterase
HFD83_RS04080	COG0741	lytic transglycosylase activity
HFD83_RS04100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFD83_RS04115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD83_RS04140	COG0778	Nitroreductase
HFD83_RS04155	COG1929	Belongs to the glycerate kinase type-1 family
HFD83_RS04160	COG0243	molybdopterin cofactor binding
HFD83_RS04165	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFD83_RS04170	COG3339	Conserved Protein
HFD83_RS04180	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HFD83_RS04195	COG1113	amino acid transport
HFD83_RS04205	COG0019	diaminopimelate decarboxylase activity
HFD83_RS04215	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS04220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HFD83_RS04250	COG0463	Glycosyl transferase, family 2
HFD83_RS04270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS04305	COG4591	ABC-type transport system involved in lipoprotein release permease component
HFD83_RS04310	COG1136	(ABC) transporter
HFD83_RS04315	COG2333	competence protein COMEC
HFD83_RS04315	COG0658	competence protein
HFD83_RS04325	COG0616	signal peptide processing
HFD83_RS04325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFD83_RS04330	COG0596	Alpha beta hydrolase
HFD83_RS04335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HFD83_RS04345	COG0628	permease
HFD83_RS04380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD83_RS04400	COG0823	Involved in the tonB-independent uptake of proteins
HFD83_RS04420	COG0824	Thioesterase
HFD83_RS04425	COG1473	amidohydrolase
HFD83_RS04445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFD83_RS04445	COG0047	phosphoribosylformylglycinamidine synthase activity
HFD83_RS04450	COG2814	Major facilitator Superfamily
HFD83_RS04460	COG1024	Enoyl-CoA hydratase
HFD83_RS04465	COG1051	belongs to the nudix hydrolase family
HFD83_RS04465	COG1056	cytidyltransferase-related domain
HFD83_RS04475	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFD83_RS04490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HFD83_RS04505	COG4625	pathogenesis
HFD83_RS04510	COG0583	DNA-binding transcription factor activity
HFD83_RS04515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HFD83_RS04520	COG4208	sulfate ABC transporter
HFD83_RS04525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HFD83_RS04535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFD83_RS04540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFD83_RS04545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HFD83_RS04565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD83_RS04580	COG0681	Belongs to the peptidase S26 family
HFD83_RS04595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HFD83_RS04605	COG1381	Involved in DNA repair and RecF pathway recombination
HFD83_RS04610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HFD83_RS04620	COG4221	oxidoreductase activity
HFD83_RS04650	COG0436	Aminotransferase
HFD83_RS04670	COG0556	nucleotide-excision repair
HFD83_RS04725	COG2070	2-Nitropropane dioxygenase
HFD83_RS04755	COG1215	transferase activity, transferring glycosyl groups
HFD83_RS04770	COG0415	Belongs to the DNA photolyase family
HFD83_RS04780	COG1252	NADH dehydrogenase
HFD83_RS04785	COG1686	Belongs to the peptidase S11 family
HFD83_RS04800	COG1187	pseudouridine synthase activity
HFD83_RS04825	COG0477	Major facilitator Superfamily
HFD83_RS04830	COG0583	DNA-binding transcription factor activity
HFD83_RS04845	COG0612	Peptidase, M16
HFD83_RS04880	COG0352	thiamine-phosphate diphosphorylase activity
HFD83_RS04915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD83_RS04930	COG1309	transcriptional regulator
HFD83_RS04940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFD83_RS04945	COG0076	glutamate decarboxylase activity
HFD83_RS04955	COG1522	sequence-specific DNA binding
HFD83_RS04960	COG3961	Belongs to the TPP enzyme family
HFD83_RS04965	COG1113	amino acid transport
HFD83_RS04970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HFD83_RS04975	COG0573	inorganic phosphate transmembrane transporter activity
HFD83_RS04985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFD83_RS04990	COG0616	signal peptide processing
HFD83_RS05025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HFD83_RS05030	COG1686	Belongs to the peptidase S11 family
HFD83_RS05055	COG0583	DNA-binding transcription factor activity
HFD83_RS05060	COG1067	ATP-dependent peptidase activity
HFD83_RS05105	COG1966	Carbon starvation protein
HFD83_RS05110	COG2879	small protein
HFD83_RS05145	COG2508	Transcriptional regulator
HFD83_RS05145	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFD83_RS05165	COG1113	amino acid transport
HFD83_RS05170	COG0583	DNA-binding transcription factor activity
HFD83_RS05175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD83_RS05180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD83_RS05190	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS05195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD83_RS05200	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HFD83_RS05200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD83_RS05235	COG2814	Major facilitator Superfamily
HFD83_RS05240	COG4948	Mandelate Racemase Muconate Lactonizing
HFD83_RS05250	COG1309	transcriptional regulator
HFD83_RS05275	COG1741	Belongs to the pirin family
HFD83_RS05285	COG2964	Protein conserved in bacteria
HFD83_RS05300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD83_RS05305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFD83_RS05310	COG4605	iron ion homeostasis
HFD83_RS05315	COG4604	ABC transporter, ATP-binding protein
HFD83_RS05320	COG4607	ABC-type enterochelin transport system periplasmic component
HFD83_RS05325	COG4774	siderophore transport
HFD83_RS05335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFD83_RS05340	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFD83_RS05345	COG3433	isochorismatase activity
HFD83_RS05345	COG1535	isochorismatase
HFD83_RS05360	COG1132	(ABC) transporter
HFD83_RS05370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HFD83_RS05380	COG1169	isochorismate synthase
HFD83_RS05395	COG3739	integral membrane protein
HFD83_RS05430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFD83_RS05460	COG0308	aminopeptidase N
HFD83_RS05465	COG0512	Glutamine amidotransferase of anthranilate synthase
HFD83_RS05475	COG3104	oligopeptide transport
HFD83_RS05480	COG0174	glutamine synthetase
HFD83_RS05490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFD83_RS05525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFD83_RS05530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HFD83_RS05535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFD83_RS05555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HFD83_RS05560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HFD83_RS05565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HFD83_RS05580	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS05585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD83_RS05590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD83_RS05600	COG2223	nitrite transmembrane transporter activity
HFD83_RS05610	COG0024	Methionine aminopeptidase
HFD83_RS05615	COG0052	Belongs to the universal ribosomal protein uS2 family
HFD83_RS05630	COG2207	Transcriptional regulator
HFD83_RS05655	COG2951	lytic endotransglycosylase activity
HFD83_RS05660	COG0772	Belongs to the SEDS family
HFD83_RS05675	COG0842	Transport permease protein
HFD83_RS05680	COG1131	(ABC) transporter
HFD83_RS05725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS05740	COG4215	(ABC) transporter
HFD83_RS05745	COG4160	amino acid transport
HFD83_RS05750	COG4598	ABC transporter
HFD83_RS05760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD83_RS05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD83_RS05785	COG1720	tRNA m6t6A37 methyltransferase activity
HFD83_RS05805	COG0745	RESPONSE REGULATOR receiver
HFD83_RS05810	COG0642	Histidine kinase
HFD83_RS05820	COG0494	nUDIX hydrolase
HFD83_RS05830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFD83_RS05835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFD83_RS05840	COG3139	Protein of unknown function (DUF1315)
HFD83_RS05845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFD83_RS05850	COG1301	dicarboxylic acid transport
HFD83_RS05855	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS05860	COG2819	hydrolase of the alpha beta superfamily
HFD83_RS05870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFD83_RS05880	COG2195	Cleaves the N-terminal amino acid of tripeptides
HFD83_RS05885	COG1234	tRNA 3'-trailer cleavage
HFD83_RS05915	COG2363	Small membrane protein
HFD83_RS05935	COG0513	Belongs to the DEAD box helicase family
HFD83_RS05945	COG0778	Nitroreductase
HFD83_RS06285	COG1286	toxin biosynthetic process
HFD83_RS06310	COG4783	chaperone-mediated protein folding
HFD83_RS06315	COG1610	YqeY-like protein
HFD83_RS06415	COG3111	PFAM Bacterial OB fold (BOF) protein
HFD83_RS06440	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFD83_RS06445	COG0786	glutamate:sodium symporter activity
HFD83_RS06455	COG2186	Transcriptional regulator
HFD83_RS06505	COG0477	Major facilitator Superfamily
HFD83_RS06530	COG2985	domain, Protein
HFD83_RS06540	COG2995	paraquat-inducible protein a
HFD83_RS06545	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFD83_RS06545	COG3008	intermembrane lipid transfer
HFD83_RS06555	COG1794	racemase activity, acting on amino acids and derivatives
HFD83_RS06640	COG0482	sulfurtransferase activity
HFD83_RS06660	COG3173	Aminoglycoside phosphotransferase
HFD83_RS06670	COG2433	Pfam Transposase IS66
HFD83_RS06710	COG1301	dicarboxylic acid transport
HFD83_RS06720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD83_RS06725	COG2011	ABC-type metal ion transport system permease component
HFD83_RS06730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD83_RS06735	COG1464	Belongs to the NlpA lipoprotein family
HFD83_RS06740	COG0151	Belongs to the GarS family
HFD83_RS06745	COG0138	bifunctional purine biosynthesis protein purh
HFD83_RS06750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HFD83_RS06780	COG2308	Evidence 4 Homologs of previously reported genes of
HFD83_RS06790	COG1305	Transglutaminase-like
HFD83_RS06800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFD83_RS06805	COG0305	Participates in initiation and elongation during chromosome replication
HFD83_RS06830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HFD83_RS06840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFD83_RS06845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFD83_RS06870	COG1649	PFAM Uncharacterised BCR, COG1649
HFD83_RS06870	COG0726	polysaccharide deacetylase
HFD83_RS06875	COG1215	transferase activity, transferring glycosyl groups
HFD83_RS06880	COG3658	cytochrome
HFD83_RS06890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD83_RS06905	COG0583	DNA-binding transcription factor activity
HFD83_RS06925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD83_RS06930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD83_RS06945	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS06950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD83_RS06955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD83_RS06980	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HFD83_RS06985	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HFD83_RS06995	COG2205	protein histidine kinase activity
HFD83_RS07000	COG0745	RESPONSE REGULATOR receiver
HFD83_RS07005	COG0174	glutamine synthetase
HFD83_RS07025	COG0729	surface antigen
HFD83_RS07050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD83_RS07055	COG2814	Major facilitator Superfamily
HFD83_RS07070	COG0583	DNA-binding transcription factor activity
HFD83_RS07085	COG1187	pseudouridine synthase activity
HFD83_RS07105	COG0802	atpase or kinase
HFD83_RS07110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HFD83_RS07120	COG1923	regulation of RNA biosynthetic process
HFD83_RS07125	COG0697	spore germination
HFD83_RS07140	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD83_RS07150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD83_RS07155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD83_RS07155	COG0519	Catalyzes the synthesis of GMP from XMP
HFD83_RS07160	COG4302	ethanolamine ammonia-lyase activity
HFD83_RS07165	COG4303	Ethanolamine ammonia lyase large subunit
HFD83_RS07170	COG0531	amino acid
HFD83_RS07190	COG1454	alcohol dehydrogenase
HFD83_RS07195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD83_RS07205	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HFD83_RS07225	COG0308	aminopeptidase N
HFD83_RS07235	COG4221	oxidoreductase activity
HFD83_RS07245	COG1605	Chorismate mutase
HFD83_RS07260	COG1309	transcriptional regulator
HFD83_RS07270	COG0668	transmembrane transport
HFD83_RS07305	COG4773	Receptor
HFD83_RS07325	COG0488	(ABC) transporter
HFD83_RS07330	COG0589	response to stress
HFD83_RS07355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFD83_RS07365	COG3135	benzoate transporter
HFD83_RS07370	COG1522	sequence-specific DNA binding
HFD83_RS07380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFD83_RS07385	COG0583	DNA-binding transcription factor activity
HFD83_RS07395	COG0183	Belongs to the thiolase family
HFD83_RS07405	COG2030	dehydratase
HFD83_RS07425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HFD83_RS07435	COG0824	Thioesterase
HFD83_RS07440	COG1454	alcohol dehydrogenase
HFD83_RS07450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFD83_RS07470	COG0069	glutamate synthase activity
HFD83_RS07490	COG2814	Major facilitator Superfamily
HFD83_RS07505	COG0511	ligase activity, forming carbon-carbon bonds
HFD83_RS07525	COG1116	anion transmembrane transporter activity
HFD83_RS07525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD83_RS07530	COG0745	RESPONSE REGULATOR receiver
HFD83_RS07540	COG2146	nitrite reductase [NAD(P)H] activity
HFD83_RS07540	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD83_RS07545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD83_RS07550	COG0243	molybdopterin cofactor binding
HFD83_RS07560	COG0243	molybdopterin cofactor binding
HFD83_RS07565	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFD83_RS07580	COG0315	cyclic pyranopterin monophosphate synthase activity
HFD83_RS07580	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFD83_RS07585	COG0303	'Molybdopterin
HFD83_RS07595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD83_RS07600	COG0697	spore germination
HFD83_RS07620	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HFD83_RS07625	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD83_RS07680	COG2204	response regulator
HFD83_RS07685	COG3852	Histidine kinase
HFD83_RS07705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFD83_RS07710	COG0575	Belongs to the CDS family
HFD83_RS07745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD83_RS07760	COG2137	regulation of response to DNA damage stimulus
HFD83_RS07770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HFD83_RS07775	COG1011	Hydrolase
HFD83_RS07800	COG1522	sequence-specific DNA binding
HFD83_RS07810	COG1113	amino acid transport
HFD83_RS07825	COG0659	secondary active sulfate transmembrane transporter activity
HFD83_RS07830	COG2135	peptidase activity
HFD83_RS07845	COG3300	MHYT domain
HFD83_RS07845	COG5001	Diguanylate cyclase
HFD83_RS07865	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFD83_RS07865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD83_RS07865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFD83_RS07870	COG1105	Belongs to the carbohydrate kinase PfkB family
HFD83_RS07875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFD83_RS07875	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD83_RS07905	COG0024	Methionine aminopeptidase
HFD83_RS07910	COG0583	DNA-binding transcription factor activity
HFD83_RS07920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HFD83_RS07925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HFD83_RS07930	COG0517	IMP dehydrogenase activity
HFD83_RS07930	COG0516	GMP reductase activity
HFD83_RS07955	COG0552	protein localization to endoplasmic reticulum
HFD83_RS07965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HFD83_RS07980	COG4890	Cyd operon protein YbgT
HFD83_RS07985	COG1294	oxidase, subunit
HFD83_RS08000	COG1585	Membrane protein implicated in regulation of membrane protease activity
HFD83_RS08010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFD83_RS08015	COG4774	siderophore transport
HFD83_RS08030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFD83_RS08035	COG0569	domain protein
HFD83_RS08040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HFD83_RS08070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFD83_RS08075	COG0542	response to heat
HFD83_RS08100	COG1902	pentaerythritol trinitrate reductase activity
HFD83_RS08100	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD83_RS08145	COG2323	membrane
HFD83_RS08150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HFD83_RS08160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD83_RS08165	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD83_RS08170	COG0183	Belongs to the thiolase family
HFD83_RS08175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFD83_RS08180	COG0596	Alpha beta hydrolase
HFD83_RS08185	COG2271	Major facilitator Superfamily
HFD83_RS08190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD83_RS08195	COG3485	protocatechuate 3,4-dioxygenase
HFD83_RS08200	COG3485	protocatechuate 3,4-dioxygenase
HFD83_RS08205	COG0710	3-dehydroquinate dehydratase activity
HFD83_RS08210	COG3420	alginic acid biosynthetic process
HFD83_RS08215	COG3659	wide pore channel activity
HFD83_RS08220	COG4993	Dehydrogenase
HFD83_RS08230	COG2391	methyltransferase activity
HFD83_RS08245	COG1414	Transcriptional regulator
HFD83_RS08250	COG0583	DNA-binding transcription factor activity
HFD83_RS08255	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS08280	COG2814	Major facilitator Superfamily
HFD83_RS08290	COG0154	amidase activity
HFD83_RS08310	COG4638	Rieske (2fe-2S)
HFD83_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS08330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD83_RS08340	COG3733	amine oxidase
HFD83_RS08350	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS08360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD83_RS08365	COG0183	Belongs to the thiolase family
HFD83_RS08370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD83_RS08375	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD83_RS08385	COG4829	muconolactone delta-isomerase
HFD83_RS08390	COG4948	Mandelate Racemase Muconate Lactonizing
HFD83_RS08395	COG0583	DNA-binding transcription factor activity
HFD83_RS08405	COG2186	Transcriptional regulator
HFD83_RS08425	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS08445	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS08450	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS08455	COG3829	transcription factor binding
HFD83_RS08465	COG3162	membrane
HFD83_RS08480	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS08495	COG0753	catalase activity
HFD83_RS08515	COG1846	Transcriptional regulator
HFD83_RS08520	COG1902	pentaerythritol trinitrate reductase activity
HFD83_RS08520	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD83_RS08530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFD83_RS08560	COG1309	transcriptional regulator
HFD83_RS08570	COG1335	isochorismatase
HFD83_RS08575	COG0583	DNA-binding transcription factor activity
HFD83_RS08585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD83_RS08585	COG0475	glutathione-regulated potassium exporter activity
HFD83_RS08595	COG1473	amidohydrolase
HFD83_RS08605	COG2831	hemolysin activation secretion protein
HFD83_RS08610	COG3210	domain, Protein
HFD83_RS08640	COG2188	Transcriptional regulator
HFD83_RS08655	COG0583	DNA-binding transcription factor activity
HFD83_RS08685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD83_RS08705	COG1566	PFAM secretion protein HlyD family protein
HFD83_RS08720	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS08725	COG0129	dihydroxy-acid dehydratase activity
HFD83_RS08735	COG0583	DNA-binding transcription factor activity
HFD83_RS08740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HFD83_RS08750	COG2084	Dehydrogenase
HFD83_RS08755	COG2207	Transcriptional regulator
HFD83_RS08770	COG1064	alcohol dehydrogenase
HFD83_RS08785	COG1120	ATPase activity
HFD83_RS08805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD83_RS08920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HFD83_RS08970	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS08985	COG2207	Transcriptional regulator
HFD83_RS08995	COG2205	protein histidine kinase activity
HFD83_RS09000	COG0745	RESPONSE REGULATOR receiver
HFD83_RS09005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS09010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD83_RS09015	COG1538	Outer membrane efflux protein
HFD83_RS09025	COG2072	flavoprotein involved in K transport
HFD83_RS09045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD83_RS09065	COG3539	Fimbrial protein
HFD83_RS09095	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HFD83_RS09105	COG0753	catalase activity
HFD83_RS09120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFD83_RS09185	COG1535	isochorismatase
HFD83_RS09185	COG3433	isochorismatase activity
HFD83_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS09195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HFD83_RS09200	COG4149	molybdate abc transporter
HFD83_RS09205	COG0725	ABC transporter, periplasmic molybdate-binding protein
HFD83_RS09215	COG4638	Rieske (2fe-2S)
HFD83_RS09220	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD83_RS09225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD83_RS09225	COG0543	2 iron, 2 sulfur cluster binding
HFD83_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS09265	COG2207	Transcriptional regulator
HFD83_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS09280	COG2610	gluconate transmembrane transporter activity
HFD83_RS09290	COG0583	DNA-binding transcription factor activity
HFD83_RS09300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD83_RS09305	COG2031	fatty acid transporter
HFD83_RS09310	COG0183	Belongs to the thiolase family
HFD83_RS09315	COG0583	DNA-binding transcription factor activity
HFD83_RS09320	COG0583	DNA-binding transcription factor activity
HFD83_RS09335	COG1027	Aspartate ammonia-lyase
HFD83_RS09345	COG0477	Major facilitator Superfamily
HFD83_RS09365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD83_RS09370	COG4521	taurine ABC transporter
HFD83_RS09385	COG2188	Transcriptional regulator
HFD83_RS09395	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFD83_RS09400	COG1733	regulation of RNA biosynthetic process
HFD83_RS09405	COG2207	Transcriptional regulator
HFD83_RS09405	COG3708	Transcriptional regulator
HFD83_RS09420	COG0730	response to heat
HFD83_RS09430	COG3453	Protein conserved in bacteria
HFD83_RS09430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD83_RS09440	COG3781	membrane
HFD83_RS09445	COG1063	alcohol dehydrogenase
HFD83_RS09455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFD83_RS09460	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFD83_RS09465	COG0022	dehydrogenase e1 component
HFD83_RS09470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFD83_RS09475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFD83_RS09490	COG3706	GGDEF domain
HFD83_RS09505	COG0133	tryptophan synthase activity
HFD83_RS09515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFD83_RS09550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFD83_RS09635	COG0842	Transport permease protein
HFD83_RS09640	COG0842	Transport permease protein
HFD83_RS09645	COG1131	(ABC) transporter
HFD83_RS09660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HFD83_RS09665	COG4773	Receptor
HFD83_RS09685	COG0730	response to heat
HFD83_RS09690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFD83_RS09710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFD83_RS09765	COG4264	IucA IucC family
HFD83_RS09770	COG4264	IucA IucC family
HFD83_RS09790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFD83_RS09805	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS09810	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS09815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFD83_RS09820	COG2207	Transcriptional regulator
HFD83_RS09825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD83_RS09830	COG0776	regulation of translation
HFD83_RS09855	COG0822	iron-sulfur transferase activity
HFD83_RS09860	COG0316	Belongs to the HesB IscA family
HFD83_RS09890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HFD83_RS09910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFD83_RS09915	COG0702	epimerase
HFD83_RS09950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFD83_RS09960	COG0339	signal peptide processing
HFD83_RS10010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFD83_RS10015	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFD83_RS10045	COG0776	regulation of translation
HFD83_RS10110	COG0084	hydrolase, TatD family'
HFD83_RS10130	COG1663	tetraacyldisaccharide 4'-kinase activity
HFD83_RS10135	COG1132	(ABC) transporter
HFD83_RS10145	COG0811	peptide transport
HFD83_RS10150	COG1475	DNA binding
HFD83_RS10155	COG1192	Involved in chromosome partitioning
HFD83_RS10165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFD83_RS10180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HFD83_RS10185	COG0191	fructose-bisphosphate aldolase activity
HFD83_RS10205	COG0424	maF-like protein
HFD83_RS10210	COG2850	peptidyl-arginine hydroxylation
HFD83_RS10220	COG0640	Transcriptional regulator
HFD83_RS10230	COG3619	membrane
HFD83_RS10235	COG3122	Protein conserved in bacteria
HFD83_RS10240	COG1132	(ABC) transporter
HFD83_RS10260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFD83_RS10265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFD83_RS10275	COG0506	proline dehydrogenase activity
HFD83_RS10275	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD83_RS10275	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HFD83_RS10280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HFD83_RS10295	COG3698	Phosphodiester glycosidase
HFD83_RS10305	COG2353	YceI-like domain
HFD83_RS10315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HFD83_RS10360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HFD83_RS10360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HFD83_RS10385	COG3539	Fimbrial protein
HFD83_RS10390	COG3121	Chaperone
HFD83_RS10415	COG0697	spore germination
HFD83_RS10425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD83_RS10435	COG0583	DNA-binding transcription factor activity
HFD83_RS10455	COG1309	transcriptional regulator
HFD83_RS10470	COG1522	sequence-specific DNA binding
HFD83_RS10480	COG1126	abc transporter atp-binding protein
HFD83_RS10485	COG0765	amino acid transport
HFD83_RS10490	COG0765	amino acid transport
HFD83_RS10520	COG1464	Belongs to the NlpA lipoprotein family
HFD83_RS10530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFD83_RS10535	COG2011	ABC-type metal ion transport system permease component
HFD83_RS10540	COG0012	GTP binding
HFD83_RS10565	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFD83_RS10605	COG0386	Belongs to the glutathione peroxidase family
HFD83_RS10615	COG0436	Aminotransferase
HFD83_RS10655	COG3634	alkyl hydroperoxide reductase activity
HFD83_RS10670	COG0583	DNA-binding transcription factor activity
HFD83_RS10675	COG0798	PFAM Bile acid sodium symporter
HFD83_RS10680	COG0640	Transcriptional regulator
HFD83_RS10695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HFD83_RS10705	COG0583	DNA-binding transcription factor activity
HFD83_RS10715	COG1953	Uracil, thiamine, allantoin
HFD83_RS10725	COG2175	clavaminate synthase activity
HFD83_RS10730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD83_RS10735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HFD83_RS10740	COG4521	taurine ABC transporter
HFD83_RS10750	COG0477	Major facilitator Superfamily
HFD83_RS10775	COG1271	oxidase subunit
HFD83_RS10780	COG1294	oxidase, subunit
HFD83_RS10790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD83_RS10810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HFD83_RS10830	COG3052	prosthetic group binding
HFD83_RS10835	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HFD83_RS10845	COG2814	Major facilitator Superfamily
HFD83_RS10865	COG1346	cytolysis
HFD83_RS10875	COG0583	DNA-binding transcription factor activity
HFD83_RS10880	COG0625	glutathione transferase activity
HFD83_RS10885	COG0625	glutathione transferase activity
HFD83_RS10890	COG0583	DNA-binding transcription factor activity
HFD83_RS10905	COG1045	serine acetyltransferase
HFD83_RS10910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFD83_RS10915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFD83_RS10925	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS10940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD83_RS10945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD83_RS10950	COG1126	abc transporter atp-binding protein
HFD83_RS10955	COG0765	amino acid transport
HFD83_RS10960	COG0765	amino acid transport
HFD83_RS10980	COG2205	protein histidine kinase activity
HFD83_RS10980	COG0784	Response regulator, receiver
HFD83_RS11000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD83_RS11020	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS11070	COG0583	DNA-binding transcription factor activity
HFD83_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
HFD83_RS11095	COG1309	transcriptional regulator
HFD83_RS11100	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS11105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFD83_RS11110	COG1024	Enoyl-CoA hydratase
HFD83_RS11115	COG4770	biotin carboxylase activity
HFD83_RS11125	COG0583	DNA-binding transcription factor activity
HFD83_RS11140	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS11150	COG2814	Major facilitator Superfamily
HFD83_RS11160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HFD83_RS11165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HFD83_RS11170	COG2814	Major facilitator Superfamily
HFD83_RS11175	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS11180	COG1024	Enoyl-CoA hydratase
HFD83_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS11190	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD83_RS11195	COG0183	Belongs to the thiolase family
HFD83_RS11205	COG2814	Major facilitator Superfamily
HFD83_RS11215	COG1024	Enoyl-CoA hydratase
HFD83_RS11230	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS11235	COG2814	Major facilitator Superfamily
HFD83_RS11240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFD83_RS11245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HFD83_RS11260	COG3842	ATPase activity
HFD83_RS11265	COG1840	ABC-type Fe3 transport system, periplasmic component
HFD83_RS11275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD83_RS11280	COG1414	Transcriptional regulator
HFD83_RS11290	COG0583	DNA-binding transcription factor activity
HFD83_RS11295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFD83_RS11300	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS11310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HFD83_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS11325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD83_RS11330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD83_RS11335	COG2267	carboxylic ester hydrolase activity
HFD83_RS11355	COG3038	cytochrome b561
HFD83_RS11360	COG0753	catalase activity
HFD83_RS11395	COG2050	protein possibly involved in aromatic compounds catabolism
HFD83_RS11405	COG3327	negative regulation of DNA-templated transcription, initiation
HFD83_RS11410	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HFD83_RS11415	COG0183	Belongs to the thiolase family
HFD83_RS11420	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD83_RS11425	COG1024	Enoyl-CoA hydratase
HFD83_RS11430	COG1024	Enoyl-CoA hydratase
HFD83_RS11435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFD83_RS11440	COG2151	metal-sulfur cluster biosynthetic enzyme
HFD83_RS11445	COG3396	Phenylacetate-CoA oxygenase
HFD83_RS11450	COG3460	Phenylacetate-CoA oxygenase
HFD83_RS11455	COG3396	Phenylacetate-CoA oxygenase
HFD83_RS11460	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS11460	COG2030	dehydratase
HFD83_RS11465	COG1760	l-serine dehydratase
HFD83_RS11470	COG0531	amino acid
HFD83_RS11475	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS11490	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD83_RS11500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFD83_RS11520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD83_RS11530	COG0789	Transcriptional regulator
HFD83_RS11545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HFD83_RS11560	COG2807	transmembrane transport
HFD83_RS11565	COG0590	tRNA wobble adenosine to inosine editing
HFD83_RS11680	COG1116	anion transmembrane transporter activity
HFD83_RS11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFD83_RS11695	COG0864	Transcriptional regulator
HFD83_RS11715	COG2249	NAD(P)H dehydrogenase (quinone) activity
HFD83_RS11720	COG0439	Biotin carboxylase
HFD83_RS11735	COG1063	alcohol dehydrogenase
HFD83_RS11745	COG1309	transcriptional regulator
HFD83_RS11765	COG0038	chloride channel
HFD83_RS11770	COG4770	biotin carboxylase activity
HFD83_RS11790	COG1914	H( )-stimulated, divalent metal cation uptake system
HFD83_RS11795	COG0583	DNA-binding transcription factor activity
HFD83_RS11810	COG3209	COG3209 Rhs family protein
HFD83_RS11815	COG3501	Rhs element vgr protein
HFD83_RS11850	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFD83_RS11870	COG2814	Major facilitator Superfamily
HFD83_RS11880	COG1560	Kdo2-lipid A biosynthetic process
HFD83_RS11890	COG5006	permease, DMT superfamily
HFD83_RS11895	COG1522	sequence-specific DNA binding
HFD83_RS11910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFD83_RS11920	COG4122	O-methyltransferase activity
HFD83_RS11950	COG1538	Outer membrane efflux protein
HFD83_RS11960	COG1137	ATPase activity
HFD83_RS11965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HFD83_RS11975	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HFD83_RS11980	COG0517	IMP dehydrogenase activity
HFD83_RS11980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HFD83_RS12020	COG2814	Major facilitator Superfamily
HFD83_RS12055	COG1278	Cold shock
HFD83_RS12060	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS12095	COG1570	exodeoxyribonuclease VII activity
HFD83_RS12145	COG0583	DNA-binding transcription factor activity
HFD83_RS12150	COG4638	Rieske (2fe-2S)
HFD83_RS12155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFD83_RS12160	COG0633	Ferredoxin
HFD83_RS12160	COG0543	2 iron, 2 sulfur cluster binding
HFD83_RS12165	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS12170	COG3135	benzoate transporter
HFD83_RS12175	COG2814	Major facilitator Superfamily
HFD83_RS12190	COG1643	Atp-dependent helicase
HFD83_RS12195	COG0450	alkyl hydroperoxide reductase
HFD83_RS12205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HFD83_RS12215	COG3634	alkyl hydroperoxide reductase activity
HFD83_RS12235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFD83_RS12240	COG0625	glutathione transferase activity
HFD83_RS12250	COG2885	chlorophyll binding
HFD83_RS12285	COG0542	response to heat
HFD83_RS12300	COG1765	OsmC-like protein
HFD83_RS12315	COG0667	Aldo Keto reductase
HFD83_RS12330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HFD83_RS12340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFD83_RS12350	COG0527	aspartate kinase activity
HFD83_RS12360	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HFD83_RS12370	COG3038	cytochrome b561
HFD83_RS12375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFD83_RS12380	COG2252	PERMEase
HFD83_RS12390	COG2072	flavoprotein involved in K transport
HFD83_RS12405	COG1741	Belongs to the pirin family
HFD83_RS12410	COG1309	transcriptional regulator
HFD83_RS12420	COG0300	oxidoreductase activity
HFD83_RS12525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HFD83_RS12555	COG1113	amino acid transport
HFD83_RS12575	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS12595	COG0531	amino acid
HFD83_RS12605	COG1113	amino acid transport
HFD83_RS12645	COG3209	COG3209 Rhs family protein
HFD83_RS12650	COG3501	Rhs element vgr protein
HFD83_RS12675	COG4269	membrane
HFD83_RS12690	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD83_RS12690	COG1902	pentaerythritol trinitrate reductase activity
HFD83_RS12700	COG5001	Diguanylate cyclase
HFD83_RS12700	COG4251	negative regulation of phosphorylation
HFD83_RS12700	COG3706	GGDEF domain
HFD83_RS12700	COG2203	Gaf domain
HFD83_RS12710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD83_RS12730	COG4172	Belongs to the ABC transporter superfamily
HFD83_RS12735	COG4239	(ABC) transporter, permease
HFD83_RS12740	COG4174	ABC transporter (Permease)
HFD83_RS12750	COG0741	lytic transglycosylase activity
HFD83_RS12750	COG1388	LysM domain
HFD83_RS12750	COG0741	lytic transglycosylase activity
HFD83_RS12750	COG1388	LysM domain
HFD83_RS12755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD83_RS12795	COG0583	DNA-binding transcription factor activity
HFD83_RS12800	COG1279	arginine transmembrane transporter activity
HFD83_RS12820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD83_RS12825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD83_RS12830	COG0006	proline dipeptidase activity
HFD83_RS12915	COG1196	nuclear chromosome segregation
HFD83_RS12915	COG0739	heme binding
HFD83_RS12915	COG0741	lytic transglycosylase activity
HFD83_RS12975	COG4695	Portal protein
HFD83_RS13070	COG0305	Participates in initiation and elongation during chromosome replication
HFD83_RS13085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HFD83_RS13135	COG2194	sulfuric ester hydrolase activity
HFD83_RS13180	COG0739	heme binding
HFD83_RS13505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFD83_RS13530	COG3384	dioxygenase
HFD83_RS13540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFD83_RS13545	COG2878	Part of a membrane complex involved in electron transport
HFD83_RS13550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HFD83_RS13575	COG0768	penicillin binding
HFD83_RS13580	COG0742	ribosomal rna small subunit methyltransferase
HFD83_RS13595	COG0830	nickel cation binding
HFD83_RS13605	COG0804	urea catabolic process
HFD83_RS13645	COG1253	flavin adenine dinucleotide binding
HFD83_RS13650	COG2851	Citrate transporter
HFD83_RS13700	COG1773	rubredoxin
HFD83_RS13705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFD83_RS13715	COG0583	DNA-binding transcription factor activity
HFD83_RS13740	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HFD83_RS13745	COG4181	ATPase activity
HFD83_RS13790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFD83_RS13810	COG0306	phosphate transporter
HFD83_RS13820	COG3958	Transketolase
HFD83_RS13825	COG3959	Transketolase, thiamine diphosphate binding domain
HFD83_RS13830	COG2271	Major facilitator Superfamily
HFD83_RS13835	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS13840	COG0583	DNA-binding transcription factor activity
HFD83_RS13855	COG2223	nitrite transmembrane transporter activity
HFD83_RS13860	COG2207	Transcriptional regulator
HFD83_RS13865	COG2066	Belongs to the glutaminase family
HFD83_RS13870	COG0242	peptide deformylase activity
HFD83_RS13875	COG0477	Major facilitator Superfamily
HFD83_RS13885	COG0028	Belongs to the TPP enzyme family
HFD83_RS13900	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS13905	COG2267	carboxylic ester hydrolase activity
HFD83_RS13915	COG2271	Major facilitator Superfamily
HFD83_RS13920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFD83_RS13930	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS13950	COG1414	Transcriptional regulator
HFD83_RS13965	COG1024	Enoyl-CoA hydratase
HFD83_RS13975	COG1215	transferase activity, transferring glycosyl groups
HFD83_RS13980	COG0726	polysaccharide deacetylase
HFD83_RS13980	COG1649	PFAM Uncharacterised BCR, COG1649
HFD83_RS13990	COG4681	YaeQ
HFD83_RS14000	COG0523	cobalamin synthesis protein
HFD83_RS14010	COG1607	acyl-coa hydrolase
HFD83_RS14020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD83_RS14025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFD83_RS14030	COG1309	transcriptional regulator
HFD83_RS14055	COG2040	homocysteine
HFD83_RS14060	COG0531	amino acid
HFD83_RS14115	COG1595	DNA-templated transcription, initiation
HFD83_RS14125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD83_RS14130	COG0477	Major facilitator Superfamily
HFD83_RS14150	COG0084	hydrolase, TatD family'
HFD83_RS14185	COG0629	single-stranded DNA binding
HFD83_RS14240	COG0582	viral genome integration into host DNA
HFD83_RS14260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD83_RS14345	COG0592	DNA-directed DNA polymerase activity
HFD83_RS14385	COG2026	Addiction module toxin, RelE StbE family
HFD83_RS14580	COG1484	DNA-dependent DNA replication
HFD83_RS14695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HFD83_RS14730	COG0405	Gamma-glutamyltransferase
HFD83_RS14735	COG2814	Major facilitator Superfamily
HFD83_RS14745	COG2050	protein possibly involved in aromatic compounds catabolism
HFD83_RS14760	COG1090	epimerase
HFD83_RS14780	COG0420	3'-5' exonuclease activity
HFD83_RS14805	COG0735	belongs to the Fur family
HFD83_RS14810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFD83_RS14830	COG0121	glutamine amidotransferase
HFD83_RS14845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD83_RS14855	COG0210	DNA helicase
HFD83_RS14860	COG2885	chlorophyll binding
HFD83_RS14865	COG0204	Acyl-transferase
HFD83_RS14880	COG2894	cell division
HFD83_RS14900	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS14905	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HFD83_RS14905	COG1674	ftsk spoiiie
HFD83_RS14910	COG0492	ferredoxin-NADP+ reductase activity
HFD83_RS14915	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HFD83_RS14925	COG0456	acetyltransferase
HFD83_RS14985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD83_RS14985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HFD83_RS15005	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS15025	COG0473	3-isopropylmalate dehydrogenase activity
HFD83_RS15030	COG0583	DNA-binding transcription factor activity
HFD83_RS15050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFD83_RS15075	COG0564	pseudouridine synthase activity
HFD83_RS15085	COG0358	DNA primase activity
HFD83_RS15100	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HFD83_RS15130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HFD83_RS15160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFD83_RS15170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFD83_RS15170	COG0351	phosphomethylpyrimidine kinase
HFD83_RS15170	COG0352	thiamine-phosphate diphosphorylase activity
HFD83_RS15180	COG1652	LysM domain
HFD83_RS15205	COG1399	metal-binding, possibly nucleic acid-binding protein
HFD83_RS15210	COG3101	peptidyl-lysine hydroxylation
HFD83_RS15215	COG0009	L-threonylcarbamoyladenylate synthase
HFD83_RS15220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HFD83_RS15225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFD83_RS15240	COG4106	trans-aconitate 2-methyltransferase activity
HFD83_RS15255	COG2226	methyltransferase
HFD83_RS15255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD83_RS15255	COG0596	Alpha beta hydrolase
HFD83_RS15260	COG1877	trehalose-phosphatase activity
HFD83_RS15265	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HFD83_RS15270	COG2223	nitrite transmembrane transporter activity
HFD83_RS15290	COG1196	nuclear chromosome segregation
HFD83_RS15300	COG0730	response to heat
HFD83_RS15315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HFD83_RS15325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD83_RS15375	COG0489	protein tyrosine kinase activity
HFD83_RS15385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD83_RS15385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD83_RS15415	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HFD83_RS15420	COG2081	HI0933 family
HFD83_RS15430	COG0668	transmembrane transport
HFD83_RS15450	COG0583	DNA-binding transcription factor activity
HFD83_RS15470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFD83_RS15475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD83_RS15505	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HFD83_RS15540	COG2205	protein histidine kinase activity
HFD83_RS15545	COG0745	RESPONSE REGULATOR receiver
HFD83_RS15565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFD83_RS15575	COG2205	protein histidine kinase activity
HFD83_RS15645	COG4993	Dehydrogenase
HFD83_RS15665	COG0384	phenazine biosynthesis protein PhzF
HFD83_RS15685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFD83_RS15700	COG0583	DNA-binding transcription factor activity
HFD83_RS15720	COG1473	amidohydrolase
HFD83_RS15730	COG0583	DNA-binding transcription factor activity
HFD83_RS15745	COG0583	DNA-binding transcription factor activity
HFD83_RS15750	COG1053	succinate dehydrogenase
HFD83_RS15760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFD83_RS15765	COG2814	Major facilitator Superfamily
HFD83_RS15770	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS15775	COG0583	DNA-binding transcription factor activity
HFD83_RS15780	COG1063	alcohol dehydrogenase
HFD83_RS15810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFD83_RS15815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFD83_RS15820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD83_RS15835	COG3667	copper resistance
HFD83_RS15840	COG2132	Multicopper oxidase
HFD83_RS15850	COG0561	phosphatase activity
HFD83_RS15855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HFD83_RS15880	COG1214	PFAM Peptidase M22, glycoprotease
HFD83_RS15930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFD83_RS15940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFD83_RS15945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HFD83_RS15950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFD83_RS16010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFD83_RS16020	COG1846	Transcriptional regulator
HFD83_RS16025	COG1764	response to oxidative stress
HFD83_RS16065	COG0037	tRNA processing
HFD83_RS16075	COG0248	Ppx GppA phosphatase
HFD83_RS16105	COG0072	phenylalanine-tRNA ligase activity
HFD83_RS16145	COG1238	metal cluster binding
HFD83_RS16150	COG0625	glutathione transferase activity
HFD83_RS16165	COG0318	PFAM AMP-dependent synthetase and ligase
HFD83_RS16170	COG3028	Belongs to the UPF0307 family
HFD83_RS16175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HFD83_RS16195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HFD83_RS16200	COG0617	tRNA 3'-terminal CCA addition
HFD83_RS16205	COG1555	photosystem II stabilization
HFD83_RS16210	COG3956	TIGRFAM MazG family protein
HFD83_RS16220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFD83_RS16240	COG0784	Response regulator, receiver
HFD83_RS16240	COG5002	protein histidine kinase activity
HFD83_RS16240	COG2205	protein histidine kinase activity
HFD83_RS16245	COG1024	Enoyl-CoA hydratase
HFD83_RS16250	COG2084	Dehydrogenase
HFD83_RS16255	COG3622	Belongs to the hyi family
HFD83_RS16285	COG0697	spore germination
HFD83_RS16295	COG2814	Major facilitator Superfamily
HFD83_RS16300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HFD83_RS16310	COG0583	DNA-binding transcription factor activity
HFD83_RS16320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HFD83_RS16335	COG0084	hydrolase, TatD family'
HFD83_RS16350	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFD83_RS16380	COG0440	acetolactate synthase activity
HFD83_RS16385	COG0028	Belongs to the TPP enzyme family
HFD83_RS16410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HFD83_RS16415	COG0577	efflux transmembrane transporter activity
HFD83_RS16415	COG1136	(ABC) transporter
HFD83_RS16420	COG1538	Outer membrane efflux protein
HFD83_RS16435	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HFD83_RS16440	COG1162	GTPase activity
HFD83_RS16450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HFD83_RS16470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HFD83_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS16515	COG2986	histidine ammonia-lyase
HFD83_RS16530	COG0318	PFAM AMP-dependent synthetase and ligase
HFD83_RS16540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD83_RS16585	COG1426	Protein conserved in bacteria
HFD83_RS16620	COG0793	Belongs to the peptidase S41A family
HFD83_RS16635	COG2267	carboxylic ester hydrolase activity
HFD83_RS16645	COG1012	belongs to the aldehyde dehydrogenase family
HFD83_RS16650	COG3265	gluconokinase activity
HFD83_RS16660	COG0800	Aldolase
HFD83_RS16670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFD83_RS16675	COG0857	belongs to the CobB CobQ family
HFD83_RS16675	COG0280	phosphate acetyltransferase
HFD83_RS16680	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD83_RS16680	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFD83_RS16700	COG0740	serine-type endopeptidase activity
HFD83_RS16710	COG4774	siderophore transport
HFD83_RS16720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFD83_RS16730	COG2813	Specifically methylates the guanine in position
HFD83_RS16730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFD83_RS16830	COG0788	formyltetrahydrofolate deformylase activity
HFD83_RS16855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD83_RS16855	COG4651	solute:proton antiporter activity
HFD83_RS16875	COG0724	RNA recognition motif
HFD83_RS16880	COG0210	DNA helicase
HFD83_RS16905	COG1733	regulation of RNA biosynthetic process
HFD83_RS16915	COG2900	Belongs to the SlyX family
HFD83_RS16925	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS16930	COG1560	Kdo2-lipid A biosynthetic process
HFD83_RS16940	COG1301	dicarboxylic acid transport
HFD83_RS16995	COG0473	3-isopropylmalate dehydrogenase activity
HFD83_RS17060	COG0583	DNA-binding transcription factor activity
HFD83_RS17070	COG0625	glutathione transferase activity
HFD83_RS17075	COG2378	regulation of single-species biofilm formation
HFD83_RS17080	COG0546	phosphoglycolate phosphatase activity
HFD83_RS17095	COG1530	ribonuclease E activity
HFD83_RS17100	COG0318	PFAM AMP-dependent synthetase and ligase
HFD83_RS17115	COG0583	DNA-binding transcription factor activity
HFD83_RS17120	COG4221	oxidoreductase activity
HFD83_RS17125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HFD83_RS17135	COG0534	Mate efflux family protein
HFD83_RS17150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HFD83_RS17190	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HFD83_RS17195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFD83_RS17210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFD83_RS17220	COG0644	oxidoreductase
HFD83_RS17220	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HFD83_RS17225	COG0425	Belongs to the sulfur carrier protein TusA family
HFD83_RS17230	COG4535	Mg2 and Co2 transporter CorC
HFD83_RS17240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFD83_RS17260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HFD83_RS17265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HFD83_RS17265	COG0475	glutathione-regulated potassium exporter activity
HFD83_RS17270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HFD83_RS17280	COG0484	heat shock protein binding
HFD83_RS17285	COG0789	Transcriptional regulator
HFD83_RS17290	COG0598	Magnesium transport protein CorA
HFD83_RS17310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFD83_RS17315	COG1074	ATP-dependent DNA helicase activity
HFD83_RS17320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFD83_RS17340	COG2226	methyltransferase
HFD83_RS17355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFD83_RS17360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HFD83_RS17375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFD83_RS17375	COG2111	Na H antiporter
HFD83_RS17380	COG1006	Multisubunit Na H antiporter MnhC subunit
HFD83_RS17385	COG0651	ATP synthesis coupled electron transport
HFD83_RS17395	COG2212	antiporter activity
HFD83_RS17415	COG0195	Participates in both transcription termination and antitermination
HFD83_RS17465	COG0237	dephospho-CoA kinase activity
HFD83_RS17475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFD83_RS17490	COG0497	DNA recombination
HFD83_RS17500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFD83_RS17530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFD83_RS17530	COG2169	Transcriptional regulator
HFD83_RS17535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HFD83_RS17600	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFD83_RS17615	COG0326	Molecular chaperone. Has ATPase activity
HFD83_RS17630	COG2056	Na+-H+ antiporter family
HFD83_RS17635	COG0596	Alpha beta hydrolase
HFD83_RS17730	COG0546	phosphoglycolate phosphatase activity
HFD83_RS17735	COG1716	ATPase activity
HFD83_RS17780	COG0181	hydroxymethylbilane synthase activity
HFD83_RS17790	COG3275	phosphorelay sensor kinase activity
HFD83_RS17810	COG1538	Outer membrane efflux protein
HFD83_RS17815	COG0697	spore germination
HFD83_RS17840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFD83_RS17845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HFD83_RS17850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFD83_RS17855	COG0772	Belongs to the SEDS family
HFD83_RS17880	COG4974	Belongs to the 'phage' integrase family
HFD83_RS17885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD83_RS17895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFD83_RS17905	COG2197	response regulator
HFD83_RS17920	COG0793	Belongs to the peptidase S41A family
HFD83_RS17925	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HFD83_RS17930	COG0795	lipopolysaccharide-transporting ATPase activity
HFD83_RS17970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD83_RS17970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HFD83_RS17980	COG0004	ammonium transporteR
HFD83_RS17985	COG0347	Belongs to the P(II) protein family
HFD83_RS17995	COG0606	chelatase, subunit chli
HFD83_RS18065	COG0659	secondary active sulfate transmembrane transporter activity
HFD83_RS18070	COG0589	response to stress
HFD83_RS18110	COG0606	chelatase, subunit chli
HFD83_RS18115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFD83_RS18125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFD83_RS18140	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HFD83_RS18155	COG0318	PFAM AMP-dependent synthetase and ligase
HFD83_RS18165	COG0477	Major facilitator Superfamily
HFD83_RS18170	COG2860	membrane
HFD83_RS18180	COG1253	flavin adenine dinucleotide binding
HFD83_RS18200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFD83_RS18235	COG0655	NAD(P)H dehydrogenase (quinone) activity
HFD83_RS18245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFD83_RS18280	COG1309	transcriptional regulator
HFD83_RS18315	COG0758	DNA mediated transformation
HFD83_RS18325	COG0697	spore germination
HFD83_RS18330	COG1309	transcriptional regulator
HFD83_RS18345	COG0386	Belongs to the glutathione peroxidase family
HFD83_RS18410	COG1121	(ABC) transporter
HFD83_RS18415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFD83_RS18420	COG1280	lysine exporter protein (LysE YggA)
HFD83_RS18425	COG2837	iron assimilation
HFD83_RS18435	COG0281	malic enzyme
HFD83_RS18480	COG0519	Catalyzes the synthesis of GMP from XMP
HFD83_RS18480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFD83_RS18485	COG4399	Belongs to the UPF0754 family
HFD83_RS18490	COG2259	Doxx family
HFD83_RS18495	COG0586	Pfam SNARE associated Golgi protein
HFD83_RS18510	COG1192	Involved in chromosome partitioning
HFD83_RS18520	COG0271	Belongs to the BolA IbaG family
HFD83_RS18540	COG2267	carboxylic ester hydrolase activity
HFD83_RS18560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFD83_RS18560	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HFD83_RS18560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFD83_RS18560	COG3321	synthase
HFD83_RS18565	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS18575	COG2197	response regulator
HFD83_RS18585	COG3916	Acyl-homoserine-lactone synthase
HFD83_RS18590	COG0477	Major facilitator Superfamily
HFD83_RS18595	COG1024	Enoyl-CoA hydratase
HFD83_RS18600	COG1024	Enoyl-CoA hydratase
HFD83_RS18605	COG1960	acyl-CoA dehydrogenase activity
HFD83_RS18610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFD83_RS18630	COG1113	amino acid transport
HFD83_RS18635	COG1113	amino acid transport
HFD83_RS18640	COG0251	oxidation-reduction process
HFD83_RS18680	COG0564	pseudouridine synthase activity
HFD83_RS18740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFD83_RS18755	COG1802	Transcriptional regulator
HFD83_RS18765	COG1448	Aminotransferase
HFD83_RS18770	COG0277	FAD linked oxidase domain protein
HFD83_RS18780	COG2186	Transcriptional regulator
HFD83_RS18790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFD83_RS18800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HFD83_RS18815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFD83_RS18820	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HFD83_RS18840	COG1215	transferase activity, transferring glycosyl groups
HFD83_RS18850	COG0438	transferase activity, transferring glycosyl groups
HFD83_RS18875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HFD83_RS18880	COG1596	polysaccharide export
HFD83_RS18905	COG0728	peptidoglycan biosynthetic process
HFD83_RS18910	COG3023	N-Acetylmuramoyl-L-alanine amidase
HFD83_RS18965	COG0546	phosphoglycolate phosphatase activity
HFD83_RS18970	COG1028	Short-chain dehydrogenase reductase Sdr
HFD83_RS18990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD83_RS18995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFD83_RS19000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFD83_RS19005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFD83_RS19010	COG1116	anion transmembrane transporter activity
HFD83_RS19015	COG1309	transcriptional regulator
HFD83_RS19020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HFD83_RS19030	COG0196	riboflavin kinase activity
HFD83_RS19035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFD83_RS19045	COG1047	Peptidyl-prolyl cis-trans
HFD83_RS19085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFD83_RS19140	COG2951	lytic endotransglycosylase activity
HFD83_RS19145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFD83_RS19160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFD83_RS19170	COG0671	phosphoesterase, PA-phosphatase related
HFD83_RS19175	COG0861	Integral membrane protein TerC family
HFD83_RS19185	COG0754	glutathionylspermidine amidase activity
HFD83_RS19195	COG0402	S-adenosylhomocysteine deaminase activity
HFD83_RS19210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFD83_RS19215	COG1230	cation diffusion facilitator family transporter
HFD83_RS19230	COG0706	membrane insertase activity
HFD83_RS19300	COG1525	nuclease
HFD83_RS19365	COG1475	DNA binding
HFD83_RS19380	COG3853	Toxic anion resistance protein (TelA)
HFD83_RS19515	COG3328	transposase activity
HFD83_RS19565	COG0741	lytic transglycosylase activity
HFD83_RS19600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process