locus-tag	class	description
FR761_RS00005	COG0668	transmembrane transport
FR761_RS00010	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR761_RS00015	COG1519	Transferase
FR761_RS00020	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS00040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FR761_RS00065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR761_RS00065	COG0426	domain, Protein
FR761_RS00070	COG4774	siderophore transport
FR761_RS00075	COG2119	membrane
FR761_RS00085	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR761_RS00095	COG4942	peptidase
FR761_RS00110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FR761_RS00120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FR761_RS00140	COG0189	ligase activity
FR761_RS00160	COG0708	Exodeoxyribonuclease III
FR761_RS00165	COG1393	Belongs to the ArsC family
FR761_RS00180	COG3706	GGDEF domain
FR761_RS00215	COG2351	hydroxyisourate hydrolase activity
FR761_RS00220	COG2233	PERMEase
FR761_RS00230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR761_RS00240	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
FR761_RS00250	COG3150	esterase
FR761_RS00335	COG2918	glutathione biosynthetic process
FR761_RS00350	COG2733	membrane
FR761_RS00355	COG0436	Aminotransferase
FR761_RS00360	COG0534	Mate efflux family protein
FR761_RS00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FR761_RS00460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FR761_RS00470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FR761_RS00515	COG1002	Type II restriction enzyme, methylase subunits
FR761_RS00520	COG1061	Type III restriction enzyme res subunit
FR761_RS00530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FR761_RS00545	COG3328	transposase activity
FR761_RS00575	COG1078	dGTPase activity
FR761_RS00590	COG3293	Transposase
FR761_RS00620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FR761_RS00625	COG0546	phosphoglycolate phosphatase activity
FR761_RS00640	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS00680	COG0010	Belongs to the arginase family
FR761_RS00710	COG2188	Transcriptional regulator
FR761_RS00720	COG0523	cobalamin synthesis protein
FR761_RS00730	COG1113	amino acid transport
FR761_RS00740	COG0625	glutathione transferase activity
FR761_RS00760	COG1683	Conserved Protein
FR761_RS00765	COG0534	Mate efflux family protein
FR761_RS00770	COG0385	Bile acid
FR761_RS00775	COG1335	isochorismatase
FR761_RS00780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR761_RS00800	COG2116	formate transmembrane transporter activity
FR761_RS00805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FR761_RS00810	COG2133	pyrroloquinoline quinone binding
FR761_RS00815	COG2983	Belongs to the UPF0260 family
FR761_RS00835	COG1194	a g-specific adenine glycosylase
FR761_RS00850	COG2818	Glycosylase
FR761_RS00855	COG1064	alcohol dehydrogenase
FR761_RS00860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR761_RS00875	COG0583	DNA-binding transcription factor activity
FR761_RS00885	COG2814	Major facilitator Superfamily
FR761_RS00920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS00935	COG2233	PERMEase
FR761_RS00940	COG0583	DNA-binding transcription factor activity
FR761_RS00975	COG0733	neurotransmitter:sodium symporter activity
FR761_RS00980	COG3293	Transposase
FR761_RS01020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR761_RS01025	COG0657	acetylesterase activity
FR761_RS01090	COG2951	lytic endotransglycosylase activity
FR761_RS01095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FR761_RS01115	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FR761_RS01125	COG0671	phosphoesterase, PA-phosphatase related
FR761_RS01130	COG0861	Integral membrane protein TerC family
FR761_RS01145	COG0754	glutathionylspermidine amidase activity
FR761_RS01155	COG0402	S-adenosylhomocysteine deaminase activity
FR761_RS01170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR761_RS01175	COG1230	cation diffusion facilitator family transporter
FR761_RS01190	COG0706	membrane insertase activity
FR761_RS01215	COG0592	DNA-directed DNA polymerase activity
FR761_RS01225	COG0187	DNA topoisomerase II activity
FR761_RS01235	COG0586	Pfam SNARE associated Golgi protein
FR761_RS01240	COG0488	(ABC) transporter
FR761_RS01265	COG0596	Alpha beta hydrolase
FR761_RS01270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FR761_RS01275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR761_RS01320	COG3293	Transposase
FR761_RS01325	COG1047	Peptidyl-prolyl cis-trans
FR761_RS01335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FR761_RS01340	COG0196	riboflavin kinase activity
FR761_RS01350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FR761_RS01355	COG1309	transcriptional regulator
FR761_RS01360	COG1116	anion transmembrane transporter activity
FR761_RS01365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR761_RS01370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FR761_RS01375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR761_RS01380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR761_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS01405	COG0546	phosphoglycolate phosphatase activity
FR761_RS01475	COG3023	N-Acetylmuramoyl-L-alanine amidase
FR761_RS01480	COG0728	peptidoglycan biosynthetic process
FR761_RS01505	COG1596	polysaccharide export
FR761_RS01510	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FR761_RS01520	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FR761_RS01535	COG2244	polysaccharide biosynthetic process
FR761_RS01540	COG0463	Glycosyl transferase, family 2
FR761_RS01540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FR761_RS01545	COG0463	Glycosyl transferase, family 2
FR761_RS01545	COG1216	Glycosyl transferase, family 2
FR761_RS01555	COG0438	transferase activity, transferring glycosyl groups
FR761_RS01565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR761_RS01570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FR761_RS01585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FR761_RS01595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR761_RS01605	COG2186	Transcriptional regulator
FR761_RS01615	COG0277	FAD linked oxidase domain protein
FR761_RS01620	COG1448	Aminotransferase
FR761_RS01630	COG1802	Transcriptional regulator
FR761_RS01645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FR761_RS01680	COG0564	pseudouridine synthase activity
FR761_RS01725	COG2267	carboxylic ester hydrolase activity
FR761_RS01745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR761_RS01805	COG1538	Outer membrane efflux protein
FR761_RS01810	COG1132	(ABC) transporter
FR761_RS01825	COG4115	mRNA cleavage
FR761_RS01835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR761_RS01840	COG3550	peptidyl-serine autophosphorylation
FR761_RS01890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS01895	COG1129	ABC transporter
FR761_RS01895	COG0842	Transport permease protein
FR761_RS01900	COG0842	Transport permease protein
FR761_RS01905	COG1283	sodium-dependent phosphate transmembrane transporter activity
FR761_RS01930	COG3756	Protein conserved in bacteria
FR761_RS01965	COG0271	Belongs to the BolA IbaG family
FR761_RS01990	COG0586	Pfam SNARE associated Golgi protein
FR761_RS01995	COG2259	Doxx family
FR761_RS02000	COG4399	Belongs to the UPF0754 family
FR761_RS02005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR761_RS02005	COG0519	Catalyzes the synthesis of GMP from XMP
FR761_RS02050	COG0281	malic enzyme
FR761_RS02055	COG2837	iron assimilation
FR761_RS02060	COG1280	lysine exporter protein (LysE YggA)
FR761_RS02065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR761_RS02070	COG1121	(ABC) transporter
FR761_RS02135	COG0386	Belongs to the glutathione peroxidase family
FR761_RS02150	COG1309	transcriptional regulator
FR761_RS02155	COG0697	spore germination
FR761_RS02165	COG0758	DNA mediated transformation
FR761_RS02215	COG1309	transcriptional regulator
FR761_RS02250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR761_RS02260	COG0655	NAD(P)H dehydrogenase (quinone) activity
FR761_RS02295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR761_RS02325	COG1253	flavin adenine dinucleotide binding
FR761_RS02330	COG3012	SEC-C Motif Domain Protein
FR761_RS02335	COG2860	membrane
FR761_RS02340	COG0477	Major facilitator Superfamily
FR761_RS02350	COG0318	PFAM AMP-dependent synthetase and ligase
FR761_RS02365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FR761_RS02380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR761_RS02390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR761_RS02395	COG0606	chelatase, subunit chli
FR761_RS02405	COG0347	Belongs to the P(II) protein family
FR761_RS02410	COG0004	ammonium transporteR
FR761_RS02420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR761_RS02420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR761_RS02460	COG0795	lipopolysaccharide-transporting ATPase activity
FR761_RS02465	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FR761_RS02470	COG0793	Belongs to the peptidase S41A family
FR761_RS02485	COG2197	response regulator
FR761_RS02495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FR761_RS02505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR761_RS02510	COG4974	Belongs to the 'phage' integrase family
FR761_RS02535	COG0772	Belongs to the SEDS family
FR761_RS02540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR761_RS02545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FR761_RS02550	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FR761_RS02575	COG0697	spore germination
FR761_RS02580	COG1538	Outer membrane efflux protein
FR761_RS02600	COG3275	phosphorelay sensor kinase activity
FR761_RS02610	COG0181	hydroxymethylbilane synthase activity
FR761_RS02655	COG1716	ATPase activity
FR761_RS02660	COG0546	phosphoglycolate phosphatase activity
FR761_RS02755	COG0596	Alpha beta hydrolase
FR761_RS02760	COG2056	Na+-H+ antiporter family
FR761_RS02775	COG0326	Molecular chaperone. Has ATPase activity
FR761_RS02790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FR761_RS02865	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS02875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FR761_RS02880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR761_RS02880	COG2169	Transcriptional regulator
FR761_RS02910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FR761_RS02920	COG0497	DNA recombination
FR761_RS02935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR761_RS02945	COG0237	dephospho-CoA kinase activity
FR761_RS02995	COG0195	Participates in both transcription termination and antitermination
FR761_RS03010	COG1320	monovalent cation:proton antiporter activity
FR761_RS03015	COG2212	antiporter activity
FR761_RS03020	COG1863	multisubunit Na H antiporter MnhE subunit
FR761_RS03025	COG0651	ATP synthesis coupled electron transport
FR761_RS03030	COG1006	Multisubunit Na H antiporter MnhC subunit
FR761_RS03035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR761_RS03035	COG2111	Na H antiporter
FR761_RS03050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FR761_RS03085	COG2226	methyltransferase
FR761_RS03105	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FR761_RS03110	COG1074	ATP-dependent DNA helicase activity
FR761_RS03115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR761_RS03120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FR761_RS03135	COG0598	Magnesium transport protein CorA
FR761_RS03140	COG0789	Transcriptional regulator
FR761_RS03145	COG0484	heat shock protein binding
FR761_RS03160	COG0475	glutathione-regulated potassium exporter activity
FR761_RS03160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR761_RS03165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FR761_RS03185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR761_RS03195	COG4535	Mg2 and Co2 transporter CorC
FR761_RS03200	COG0425	Belongs to the sulfur carrier protein TusA family
FR761_RS03210	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FR761_RS03210	COG0644	oxidoreductase
FR761_RS03220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FR761_RS03235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR761_RS03240	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FR761_RS03250	COG0493	'glutamate synthase
FR761_RS03250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR761_RS03275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR761_RS03290	COG0534	Mate efflux family protein
FR761_RS03300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FR761_RS03305	COG4221	oxidoreductase activity
FR761_RS03310	COG0583	DNA-binding transcription factor activity
FR761_RS03325	COG0318	PFAM AMP-dependent synthetase and ligase
FR761_RS03330	COG1530	ribonuclease E activity
FR761_RS03345	COG0546	phosphoglycolate phosphatase activity
FR761_RS03350	COG2378	regulation of single-species biofilm formation
FR761_RS03365	COG0583	DNA-binding transcription factor activity
FR761_RS03395	COG0583	DNA-binding transcription factor activity
FR761_RS03420	COG0473	3-isopropylmalate dehydrogenase activity
FR761_RS03475	COG1301	dicarboxylic acid transport
FR761_RS03485	COG1560	Kdo2-lipid A biosynthetic process
FR761_RS03490	COG1280	lysine exporter protein (LysE YggA)
FR761_RS03500	COG0488	(ABC) transporter
FR761_RS03505	COG2900	Belongs to the SlyX family
FR761_RS03515	COG1733	regulation of RNA biosynthetic process
FR761_RS03540	COG0210	DNA helicase
FR761_RS03545	COG0724	RNA recognition motif
FR761_RS03565	COG4651	solute:proton antiporter activity
FR761_RS03565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR761_RS03590	COG0788	formyltetrahydrofolate deformylase activity
FR761_RS03690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR761_RS03690	COG2813	Specifically methylates the guanine in position
FR761_RS03700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR761_RS03710	COG4774	siderophore transport
FR761_RS03720	COG0740	serine-type endopeptidase activity
FR761_RS03740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FR761_RS03740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FR761_RS03745	COG0280	phosphate acetyltransferase
FR761_RS03745	COG0857	belongs to the CobB CobQ family
FR761_RS03750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR761_RS03760	COG0800	Aldolase
FR761_RS03770	COG3265	gluconokinase activity
FR761_RS03775	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS03785	COG2267	carboxylic ester hydrolase activity
FR761_RS03800	COG0793	Belongs to the peptidase S41A family
FR761_RS03835	COG1426	Protein conserved in bacteria
FR761_RS03875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR761_RS03885	COG1162	GTPase activity
FR761_RS03890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FR761_RS03905	COG1538	Outer membrane efflux protein
FR761_RS03910	COG0577	efflux transmembrane transporter activity
FR761_RS03910	COG1136	(ABC) transporter
FR761_RS03915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS03940	COG0028	Belongs to the TPP enzyme family
FR761_RS03945	COG0440	acetolactate synthase activity
FR761_RS03980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FR761_RS03995	COG0084	hydrolase, TatD family'
FR761_RS04005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FR761_RS04015	COG0583	DNA-binding transcription factor activity
FR761_RS04025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR761_RS04100	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS04125	COG2205	protein histidine kinase activity
FR761_RS04140	COG2132	Multicopper oxidase
FR761_RS04165	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR761_RS04220	COG2814	Major facilitator Superfamily
FR761_RS04230	COG0697	spore germination
FR761_RS04260	COG3622	Belongs to the hyi family
FR761_RS04265	COG2084	Dehydrogenase
FR761_RS04270	COG1024	Enoyl-CoA hydratase
FR761_RS04275	COG0784	Response regulator, receiver
FR761_RS04275	COG2205	protein histidine kinase activity
FR761_RS04275	COG5002	protein histidine kinase activity
FR761_RS04295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR761_RS04305	COG3956	TIGRFAM MazG family protein
FR761_RS04310	COG1555	photosystem II stabilization
FR761_RS04315	COG0617	tRNA 3'-terminal CCA addition
FR761_RS04320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR761_RS04340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR761_RS04345	COG3028	Belongs to the UPF0307 family
FR761_RS04350	COG0318	PFAM AMP-dependent synthetase and ligase
FR761_RS04370	COG0625	glutathione transferase activity
FR761_RS04375	COG1238	metal cluster binding
FR761_RS04415	COG0072	phenylalanine-tRNA ligase activity
FR761_RS04445	COG0248	Ppx GppA phosphatase
FR761_RS04455	COG0037	tRNA processing
FR761_RS04495	COG1764	response to oxidative stress
FR761_RS04500	COG1846	Transcriptional regulator
FR761_RS04510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR761_RS04570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FR761_RS04575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FR761_RS04580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FR761_RS04590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FR761_RS04625	COG1214	PFAM Peptidase M22, glycoprotease
FR761_RS04650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FR761_RS04655	COG0561	phosphatase activity
FR761_RS04685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR761_RS04690	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FR761_RS04695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FR761_RS04725	COG1063	alcohol dehydrogenase
FR761_RS04730	COG0583	DNA-binding transcription factor activity
FR761_RS04735	COG1960	acyl-CoA dehydrogenase activity
FR761_RS04740	COG2814	Major facilitator Superfamily
FR761_RS04745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FR761_RS04750	COG1309	transcriptional regulator
FR761_RS04765	COG1053	succinate dehydrogenase
FR761_RS04770	COG0583	DNA-binding transcription factor activity
FR761_RS04800	COG3293	Transposase
FR761_RS04815	COG0583	DNA-binding transcription factor activity
FR761_RS04830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR761_RS04865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FR761_RS04885	COG0745	RESPONSE REGULATOR receiver
FR761_RS04900	COG3706	GGDEF domain
FR761_RS04925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FR761_RS04955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR761_RS04960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FR761_RS04980	COG0583	DNA-binding transcription factor activity
FR761_RS05000	COG0668	transmembrane transport
FR761_RS05010	COG2081	HI0933 family
FR761_RS05015	COG2515	1-aminocyclopropane-1-carboxylate deaminase
FR761_RS05045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR761_RS05045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR761_RS05055	COG0489	protein tyrosine kinase activity
FR761_RS05115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR761_RS05125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FR761_RS05140	COG0730	response to heat
FR761_RS05150	COG1196	nuclear chromosome segregation
FR761_RS05170	COG2223	nitrite transmembrane transporter activity
FR761_RS05175	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
FR761_RS05180	COG1877	trehalose-phosphatase activity
FR761_RS05185	COG0596	Alpha beta hydrolase
FR761_RS05185	COG2226	methyltransferase
FR761_RS05185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR761_RS05200	COG4106	trans-aconitate 2-methyltransferase activity
FR761_RS05215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FR761_RS05220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FR761_RS05225	COG0009	L-threonylcarbamoyladenylate synthase
FR761_RS05230	COG3101	peptidyl-lysine hydroxylation
FR761_RS05235	COG1399	metal-binding, possibly nucleic acid-binding protein
FR761_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS05260	COG1652	LysM domain
FR761_RS05265	COG0352	thiamine-phosphate diphosphorylase activity
FR761_RS05265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR761_RS05265	COG0351	phosphomethylpyrimidine kinase
FR761_RS05275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR761_RS05305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FR761_RS05335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FR761_RS05350	COG0358	DNA primase activity
FR761_RS05360	COG0564	pseudouridine synthase activity
FR761_RS05385	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR761_RS05405	COG0583	DNA-binding transcription factor activity
FR761_RS05410	COG0473	3-isopropylmalate dehydrogenase activity
FR761_RS05420	COG0657	acetylesterase activity
FR761_RS05430	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS05450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR761_RS05450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FR761_RS05465	COG1981	membrane
FR761_RS05510	COG0456	acetyltransferase
FR761_RS05520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FR761_RS05525	COG0492	ferredoxin-NADP+ reductase activity
FR761_RS05530	COG1674	ftsk spoiiie
FR761_RS05530	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FR761_RS05535	COG1280	lysine exporter protein (LysE YggA)
FR761_RS05550	COG2894	cell division
FR761_RS05565	COG0204	Acyl-transferase
FR761_RS05570	COG2885	chlorophyll binding
FR761_RS05575	COG0210	DNA helicase
FR761_RS05585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR761_RS05600	COG0121	glutamine amidotransferase
FR761_RS05625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR761_RS05630	COG0735	belongs to the Fur family
FR761_RS05655	COG0420	3'-5' exonuclease activity
FR761_RS05675	COG1090	epimerase
FR761_RS05690	COG2050	protein possibly involved in aromatic compounds catabolism
FR761_RS05700	COG2814	Major facilitator Superfamily
FR761_RS05705	COG0405	Gamma-glutamyltransferase
FR761_RS05725	COG3328	transposase activity
FR761_RS05730	COG4681	YaeQ
FR761_RS05740	COG0726	polysaccharide deacetylase
FR761_RS05740	COG1649	PFAM Uncharacterised BCR, COG1649
FR761_RS05745	COG1215	transferase activity, transferring glycosyl groups
FR761_RS05755	COG1024	Enoyl-CoA hydratase
FR761_RS05770	COG1414	Transcriptional regulator
FR761_RS05790	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS05805	COG2271	Major facilitator Superfamily
FR761_RS05815	COG2267	carboxylic ester hydrolase activity
FR761_RS05820	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS05835	COG0028	Belongs to the TPP enzyme family
FR761_RS05845	COG0477	Major facilitator Superfamily
FR761_RS05850	COG0242	peptide deformylase activity
FR761_RS05855	COG2066	Belongs to the glutaminase family
FR761_RS05860	COG2207	Transcriptional regulator
FR761_RS05865	COG2223	nitrite transmembrane transporter activity
FR761_RS05885	COG0583	DNA-binding transcription factor activity
FR761_RS05890	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS05895	COG2271	Major facilitator Superfamily
FR761_RS05900	COG3959	Transketolase, thiamine diphosphate binding domain
FR761_RS05905	COG3958	Transketolase
FR761_RS05915	COG0306	phosphate transporter
FR761_RS05955	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FR761_RS05965	COG1061	Type III restriction enzyme res subunit
FR761_RS05970	COG1002	Type II restriction enzyme, methylase subunits
FR761_RS05990	COG2963	transposase activity
FR761_RS06000	COG4372	Transposase
FR761_RS06070	COG4181	ATPase activity
FR761_RS06075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FR761_RS06105	COG0583	DNA-binding transcription factor activity
FR761_RS06115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR761_RS06120	COG1773	rubredoxin
FR761_RS06175	COG2851	Citrate transporter
FR761_RS06185	COG1253	flavin adenine dinucleotide binding
FR761_RS06225	COG0804	urea catabolic process
FR761_RS06235	COG0830	nickel cation binding
FR761_RS06250	COG0742	ribosomal rna small subunit methyltransferase
FR761_RS06255	COG0768	penicillin binding
FR761_RS06280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FR761_RS06285	COG2878	Part of a membrane complex involved in electron transport
FR761_RS06290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR761_RS06300	COG3384	dioxygenase
FR761_RS06320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FR761_RS06360	COG0006	proline dipeptidase activity
FR761_RS06365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR761_RS06370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR761_RS06390	COG1279	arginine transmembrane transporter activity
FR761_RS06395	COG0583	DNA-binding transcription factor activity
FR761_RS06440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FR761_RS06445	COG1388	LysM domain
FR761_RS06445	COG0741	lytic transglycosylase activity
FR761_RS06445	COG1388	LysM domain
FR761_RS06445	COG0741	lytic transglycosylase activity
FR761_RS06455	COG4174	ABC transporter (Permease)
FR761_RS06460	COG4239	(ABC) transporter, permease
FR761_RS06465	COG4172	Belongs to the ABC transporter superfamily
FR761_RS06485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FR761_RS06495	COG5001	Diguanylate cyclase
FR761_RS06495	COG4251	negative regulation of phosphorylation
FR761_RS06495	COG3706	GGDEF domain
FR761_RS06495	COG2203	Gaf domain
FR761_RS06505	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR761_RS06505	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS06545	COG1113	amino acid transport
FR761_RS06555	COG0531	amino acid
FR761_RS06575	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS06595	COG1113	amino acid transport
FR761_RS06610	COG0697	spore germination
FR761_RS06615	COG2721	sulfolactate sulfo-lyase activity
FR761_RS06620	COG2271	Major facilitator Superfamily
FR761_RS06625	COG4948	Mandelate Racemase Muconate Lactonizing
FR761_RS06635	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS06640	COG2186	Transcriptional regulator
FR761_RS06665	COG1960	acyl-CoA dehydrogenase activity
FR761_RS06675	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS06680	COG1024	Enoyl-CoA hydratase
FR761_RS06685	COG2814	Major facilitator Superfamily
FR761_RS06700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR761_RS06715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FR761_RS06760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FR761_RS06775	COG0583	DNA-binding transcription factor activity
FR761_RS06780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FR761_RS06785	COG2072	flavoprotein involved in K transport
FR761_RS06790	COG0300	oxidoreductase activity
FR761_RS06800	COG1309	transcriptional regulator
FR761_RS06805	COG1741	Belongs to the pirin family
FR761_RS06820	COG2072	flavoprotein involved in K transport
FR761_RS06830	COG2252	PERMEase
FR761_RS06835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR761_RS06845	COG2801	Transposase and inactivated derivatives
FR761_RS06855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FR761_RS06865	COG0527	aspartate kinase activity
FR761_RS06875	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR761_RS06885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FR761_RS06900	COG0667	Aldo Keto reductase
FR761_RS06910	COG1765	OsmC-like protein
FR761_RS06925	COG0542	response to heat
FR761_RS06960	COG2885	chlorophyll binding
FR761_RS06970	COG0625	glutathione transferase activity
FR761_RS06975	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FR761_RS06995	COG3634	alkyl hydroperoxide reductase activity
FR761_RS07005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FR761_RS07015	COG0450	alkyl hydroperoxide reductase
FR761_RS07020	COG1643	Atp-dependent helicase
FR761_RS07035	COG2814	Major facilitator Superfamily
FR761_RS07045	COG3135	benzoate transporter
FR761_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS07055	COG0633	Ferredoxin
FR761_RS07055	COG0543	2 iron, 2 sulfur cluster binding
FR761_RS07060	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FR761_RS07065	COG4638	Rieske (2fe-2S)
FR761_RS07070	COG0583	DNA-binding transcription factor activity
FR761_RS07080	COG2871	sodium ion transport
FR761_RS07175	COG1570	exodeoxyribonuclease VII activity
FR761_RS07210	COG1280	lysine exporter protein (LysE YggA)
FR761_RS07215	COG1278	Cold shock
FR761_RS07285	COG0517	IMP dehydrogenase activity
FR761_RS07285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FR761_RS07290	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FR761_RS07300	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FR761_RS07305	COG1137	ATPase activity
FR761_RS07310	COG1538	Outer membrane efflux protein
FR761_RS07340	COG4122	O-methyltransferase activity
FR761_RS07350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FR761_RS07385	COG0598	Magnesium transport protein CorA
FR761_RS07415	COG2801	Transposase and inactivated derivatives
FR761_RS07435	COG1063	alcohol dehydrogenase
FR761_RS07450	COG0439	Biotin carboxylase
FR761_RS07455	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR761_RS07460	COG1733	regulation of RNA biosynthetic process
FR761_RS07470	COG0864	Transcriptional regulator
FR761_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR761_RS07485	COG1116	anion transmembrane transporter activity
FR761_RS07520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR761_RS07540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR761_RS07565	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS07570	COG0531	amino acid
FR761_RS07575	COG1760	l-serine dehydratase
FR761_RS07580	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS07580	COG2030	dehydratase
FR761_RS07585	COG3396	Phenylacetate-CoA oxygenase
FR761_RS07590	COG3460	Phenylacetate-CoA oxygenase
FR761_RS07595	COG3396	Phenylacetate-CoA oxygenase
FR761_RS07600	COG2151	metal-sulfur cluster biosynthetic enzyme
FR761_RS07605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR761_RS07610	COG1024	Enoyl-CoA hydratase
FR761_RS07615	COG1024	Enoyl-CoA hydratase
FR761_RS07620	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR761_RS07625	COG0183	Belongs to the thiolase family
FR761_RS07630	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FR761_RS07635	COG3327	negative regulation of DNA-templated transcription, initiation
FR761_RS07645	COG2050	protein possibly involved in aromatic compounds catabolism
FR761_RS07650	COG3209	COG3209 Rhs family protein
FR761_RS07680	COG1309	transcriptional regulator
FR761_RS07685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR761_RS07700	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR761_RS07705	COG0531	amino acid
FR761_RS07715	COG0753	catalase activity
FR761_RS07720	COG3038	cytochrome b561
FR761_RS07725	COG0583	DNA-binding transcription factor activity
FR761_RS07735	COG1414	Transcriptional regulator
FR761_RS07740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR761_RS07755	COG1840	ABC-type Fe3 transport system, periplasmic component
FR761_RS07760	COG3842	ATPase activity
FR761_RS07775	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FR761_RS07780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR761_RS07800	COG0583	DNA-binding transcription factor activity
FR761_RS07810	COG4770	biotin carboxylase activity
FR761_RS07815	COG1024	Enoyl-CoA hydratase
FR761_RS07820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR761_RS07825	COG1960	acyl-CoA dehydrogenase activity
FR761_RS07830	COG1309	transcriptional regulator
FR761_RS07835	COG0318	PFAM AMP-dependent synthetase and ligase
FR761_RS07855	COG0583	DNA-binding transcription factor activity
FR761_RS07865	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS07880	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FR761_RS07885	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS07915	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS07960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FR761_RS07980	COG0784	Response regulator, receiver
FR761_RS07980	COG2205	protein histidine kinase activity
FR761_RS08020	COG0765	amino acid transport
FR761_RS08030	COG1126	abc transporter atp-binding protein
FR761_RS08035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR761_RS08040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR761_RS08060	COG1280	lysine exporter protein (LysE YggA)
FR761_RS08065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FR761_RS08075	COG1045	serine acetyltransferase
FR761_RS08085	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS08090	COG0583	DNA-binding transcription factor activity
FR761_RS08095	COG0625	glutathione transferase activity
FR761_RS08100	COG0625	glutathione transferase activity
FR761_RS08105	COG0583	DNA-binding transcription factor activity
FR761_RS08115	COG1346	cytolysis
FR761_RS08145	COG2814	Major facilitator Superfamily
FR761_RS08155	COG0583	DNA-binding transcription factor activity
FR761_RS08165	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FR761_RS08170	COG3052	prosthetic group binding
FR761_RS08190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FR761_RS08210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR761_RS08220	COG1294	oxidase, subunit
FR761_RS08225	COG1271	oxidase subunit
FR761_RS08250	COG0477	Major facilitator Superfamily
FR761_RS08260	COG4521	taurine ABC transporter
FR761_RS08265	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FR761_RS08270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR761_RS08275	COG2175	clavaminate synthase activity
FR761_RS08285	COG1953	Uracil, thiamine, allantoin
FR761_RS08305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FR761_RS08320	COG0640	Transcriptional regulator
FR761_RS08325	COG0798	PFAM Bile acid sodium symporter
FR761_RS08330	COG0583	DNA-binding transcription factor activity
FR761_RS08345	COG3634	alkyl hydroperoxide reductase activity
FR761_RS08385	COG0436	Aminotransferase
FR761_RS08395	COG0386	Belongs to the glutathione peroxidase family
FR761_RS08435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FR761_RS08460	COG0012	GTP binding
FR761_RS08465	COG2011	ABC-type metal ion transport system permease component
FR761_RS08470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR761_RS08475	COG1464	Belongs to the NlpA lipoprotein family
FR761_RS08480	COG1464	Belongs to the NlpA lipoprotein family
FR761_RS08510	COG0765	amino acid transport
FR761_RS08515	COG0765	amino acid transport
FR761_RS08520	COG1126	abc transporter atp-binding protein
FR761_RS08530	COG1522	sequence-specific DNA binding
FR761_RS08560	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS08585	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS08605	COG3328	transposase activity
FR761_RS08620	COG0697	spore germination
FR761_RS08650	COG3121	Chaperone
FR761_RS08655	COG3539	Fimbrial protein
FR761_RS08680	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FR761_RS08680	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FR761_RS08725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR761_RS08735	COG2353	YceI-like domain
FR761_RS08745	COG3698	Phosphodiester glycosidase
FR761_RS08760	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FR761_RS08775	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FR761_RS08775	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FR761_RS08775	COG0506	proline dehydrogenase activity
FR761_RS08785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR761_RS08790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FR761_RS08810	COG1132	(ABC) transporter
FR761_RS08815	COG3122	Protein conserved in bacteria
FR761_RS08820	COG3619	membrane
FR761_RS08830	COG0640	Transcriptional regulator
FR761_RS08840	COG2850	peptidyl-arginine hydroxylation
FR761_RS08845	COG0424	maF-like protein
FR761_RS08865	COG0191	fructose-bisphosphate aldolase activity
FR761_RS08870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR761_RS08885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FR761_RS08895	COG1192	Involved in chromosome partitioning
FR761_RS08900	COG1475	DNA binding
FR761_RS08905	COG0811	peptide transport
FR761_RS08915	COG1132	(ABC) transporter
FR761_RS08920	COG1663	tetraacyldisaccharide 4'-kinase activity
FR761_RS08940	COG0084	hydrolase, TatD family'
FR761_RS09005	COG0776	regulation of translation
FR761_RS09035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FR761_RS09040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FR761_RS09095	COG0339	signal peptide processing
FR761_RS09100	COG0601	transmembrane transport
FR761_RS09105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR761_RS09140	COG0702	epimerase
FR761_RS09145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR761_RS09165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FR761_RS09195	COG0316	Belongs to the HesB IscA family
FR761_RS09200	COG0822	iron-sulfur transferase activity
FR761_RS09225	COG0776	regulation of translation
FR761_RS09230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR761_RS09235	COG2207	Transcriptional regulator
FR761_RS09240	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR761_RS09245	COG1960	acyl-CoA dehydrogenase activity
FR761_RS09250	COG1960	acyl-CoA dehydrogenase activity
FR761_RS09265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FR761_RS09300	COG4264	IucA IucC family
FR761_RS09310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR761_RS09355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FR761_RS09360	COG0406	alpha-ribazole phosphatase activity
FR761_RS09375	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR761_RS09380	COG0730	response to heat
FR761_RS09405	COG4773	Receptor
FR761_RS09410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR761_RS09450	COG0842	Transport permease protein
FR761_RS09500	COG3293	Transposase
FR761_RS09525	COG2226	methyltransferase
FR761_RS09550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FR761_RS09585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR761_RS09595	COG0133	tryptophan synthase activity
FR761_RS09610	COG3706	GGDEF domain
FR761_RS09635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR761_RS09640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FR761_RS09645	COG0022	dehydrogenase e1 component
FR761_RS09650	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR761_RS09655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR761_RS09665	COG1063	alcohol dehydrogenase
FR761_RS09670	COG3781	membrane
FR761_RS09680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR761_RS09680	COG3453	Protein conserved in bacteria
FR761_RS09690	COG0730	response to heat
FR761_RS09705	COG2207	Transcriptional regulator
FR761_RS09705	COG3708	Transcriptional regulator
FR761_RS09710	COG1733	regulation of RNA biosynthetic process
FR761_RS09715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FR761_RS09725	COG2188	Transcriptional regulator
FR761_RS09740	COG4521	taurine ABC transporter
FR761_RS09775	COG0477	Major facilitator Superfamily
FR761_RS09785	COG1027	Aspartate ammonia-lyase
FR761_RS09790	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS09800	COG0583	DNA-binding transcription factor activity
FR761_RS09805	COG0583	DNA-binding transcription factor activity
FR761_RS09810	COG0183	Belongs to the thiolase family
FR761_RS09815	COG2031	fatty acid transporter
FR761_RS09830	COG0583	DNA-binding transcription factor activity
FR761_RS09855	COG1309	transcriptional regulator
FR761_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS09880	COG2207	Transcriptional regulator
FR761_RS09895	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS09905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR761_RS09925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR761_RS09925	COG0543	2 iron, 2 sulfur cluster binding
FR761_RS09930	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
FR761_RS09935	COG4638	Rieske (2fe-2S)
FR761_RS09945	COG0725	ABC transporter, periplasmic molybdate-binding protein
FR761_RS09950	COG4149	molybdate abc transporter
FR761_RS09955	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FR761_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS09965	COG3433	isochorismatase activity
FR761_RS09965	COG1535	isochorismatase
FR761_RS10030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR761_RS10065	COG0747	negative chemotaxis
FR761_RS10070	COG0601	transmembrane transport
FR761_RS10075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR761_RS10100	COG1132	(ABC) transporter
FR761_RS10105	COG1132	(ABC) transporter
FR761_RS10135	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR761_RS10140	COG3657	addiction module killer protein
FR761_RS10170	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
FR761_RS10185	COG1979	alcohol dehydrogenase
FR761_RS10195	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS10205	COG1309	transcriptional regulator
FR761_RS10210	COG2130	NADP-dependent
FR761_RS10225	COG0582	viral genome integration into host DNA
FR761_RS10240	COG1733	regulation of RNA biosynthetic process
FR761_RS10245	COG0583	DNA-binding transcription factor activity
FR761_RS10260	COG0583	DNA-binding transcription factor activity
FR761_RS10270	COG1234	tRNA 3'-trailer cleavage
FR761_RS10275	COG0697	spore germination
FR761_RS10295	COG0071	Belongs to the small heat shock protein (HSP20) family
FR761_RS10300	COG0542	response to heat
FR761_RS10375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR761_RS10390	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
FR761_RS10415	COG0745	RESPONSE REGULATOR receiver
FR761_RS10435	COG2207	Transcriptional regulator
FR761_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS10475	COG1309	transcriptional regulator
FR761_RS10500	COG0789	Transcriptional regulator
FR761_RS10515	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR761_RS10515	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS10530	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS10550	COG2186	Transcriptional regulator
FR761_RS10560	COG0583	DNA-binding transcription factor activity
FR761_RS10565	COG4948	Mandelate Racemase Muconate Lactonizing
FR761_RS10570	COG4829	muconolactone delta-isomerase
FR761_RS10580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FR761_RS10585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FR761_RS10590	COG0183	Belongs to the thiolase family
FR761_RS10595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR761_RS10600	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS10610	COG3733	amine oxidase
FR761_RS10620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR761_RS10630	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS10640	COG4638	Rieske (2fe-2S)
FR761_RS10660	COG0154	amidase activity
FR761_RS10670	COG2814	Major facilitator Superfamily
FR761_RS10695	COG1960	acyl-CoA dehydrogenase activity
FR761_RS10700	COG0583	DNA-binding transcription factor activity
FR761_RS10705	COG1414	Transcriptional regulator
FR761_RS10720	COG2391	methyltransferase activity
FR761_RS10730	COG4993	Dehydrogenase
FR761_RS10735	COG3659	wide pore channel activity
FR761_RS10740	COG3420	alginic acid biosynthetic process
FR761_RS10745	COG0710	3-dehydroquinate dehydratase activity
FR761_RS10750	COG3485	protocatechuate 3,4-dioxygenase
FR761_RS10755	COG3485	protocatechuate 3,4-dioxygenase
FR761_RS10760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FR761_RS10765	COG2271	Major facilitator Superfamily
FR761_RS10770	COG0596	Alpha beta hydrolase
FR761_RS10775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FR761_RS10780	COG0183	Belongs to the thiolase family
FR761_RS10785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FR761_RS10790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FR761_RS10800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FR761_RS10805	COG2323	membrane
FR761_RS10850	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS10850	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR761_RS10870	COG3293	Transposase
FR761_RS10880	COG0542	response to heat
FR761_RS10885	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FR761_RS10915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FR761_RS10920	COG0569	domain protein
FR761_RS10925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR761_RS10940	COG4774	siderophore transport
FR761_RS10945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR761_RS10975	COG1294	oxidase, subunit
FR761_RS10980	COG4890	Cyd operon protein YbgT
FR761_RS10995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR761_RS11005	COG0552	protein localization to endoplasmic reticulum
FR761_RS11035	COG0516	GMP reductase activity
FR761_RS11035	COG0517	IMP dehydrogenase activity
FR761_RS11040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR761_RS11045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FR761_RS11055	COG0583	DNA-binding transcription factor activity
FR761_RS11060	COG0024	Methionine aminopeptidase
FR761_RS11090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FR761_RS11090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR761_RS11095	COG1105	Belongs to the carbohydrate kinase PfkB family
FR761_RS11100	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FR761_RS11100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR761_RS11100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR761_RS11130	COG1011	Hydrolase
FR761_RS11135	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FR761_RS11145	COG2137	regulation of response to DNA damage stimulus
FR761_RS11160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR761_RS11195	COG0575	Belongs to the CDS family
FR761_RS11200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FR761_RS11220	COG3852	Histidine kinase
FR761_RS11225	COG2204	response regulator
FR761_RS11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FR761_RS11295	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FR761_RS11315	COG0697	spore germination
FR761_RS11320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR761_RS11330	COG0303	'Molybdopterin
FR761_RS11335	COG0315	cyclic pyranopterin monophosphate synthase activity
FR761_RS11335	COG0521	Mo-molybdopterin cofactor biosynthetic process
FR761_RS11350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FR761_RS11355	COG0243	molybdopterin cofactor binding
FR761_RS11365	COG0243	molybdopterin cofactor binding
FR761_RS11370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR761_RS11375	COG2146	nitrite reductase [NAD(P)H] activity
FR761_RS11375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR761_RS11385	COG0745	RESPONSE REGULATOR receiver
FR761_RS11390	COG1116	anion transmembrane transporter activity
FR761_RS11390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR761_RS11405	COG0511	ligase activity, forming carbon-carbon bonds
FR761_RS11420	COG2814	Major facilitator Superfamily
FR761_RS11440	COG0069	glutamate synthase activity
FR761_RS11460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FR761_RS11470	COG1454	alcohol dehydrogenase
FR761_RS11475	COG0824	Thioesterase
FR761_RS11485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FR761_RS11500	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FR761_RS11505	COG2030	dehydratase
FR761_RS11515	COG0183	Belongs to the thiolase family
FR761_RS11525	COG0583	DNA-binding transcription factor activity
FR761_RS11530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR761_RS11540	COG1522	sequence-specific DNA binding
FR761_RS11545	COG3135	benzoate transporter
FR761_RS11575	COG0589	response to stress
FR761_RS11580	COG0488	(ABC) transporter
FR761_RS11600	COG4773	Receptor
FR761_RS11650	COG1605	Chorismate mutase
FR761_RS11670	COG0308	aminopeptidase N
FR761_RS11690	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FR761_RS11700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR761_RS11705	COG1454	alcohol dehydrogenase
FR761_RS11725	COG0531	amino acid
FR761_RS11730	COG4303	Ethanolamine ammonia lyase large subunit
FR761_RS11735	COG4302	ethanolamine ammonia-lyase activity
FR761_RS11740	COG0519	Catalyzes the synthesis of GMP from XMP
FR761_RS11740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR761_RS11755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR761_RS11765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR761_RS11780	COG0697	spore germination
FR761_RS11785	COG1923	regulation of RNA biosynthetic process
FR761_RS11795	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FR761_RS11800	COG0802	atpase or kinase
FR761_RS11820	COG1187	pseudouridine synthase activity
FR761_RS11835	COG0583	DNA-binding transcription factor activity
FR761_RS11850	COG2814	Major facilitator Superfamily
FR761_RS11855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR761_RS11890	COG0729	surface antigen
FR761_RS11910	COG0174	glutamine synthetase
FR761_RS11915	COG0745	RESPONSE REGULATOR receiver
FR761_RS11920	COG2205	protein histidine kinase activity
FR761_RS11930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FR761_RS11935	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FR761_RS11960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FR761_RS11965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR761_RS11970	COG1960	acyl-CoA dehydrogenase activity
FR761_RS11985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR761_RS11990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR761_RS12005	COG3328	transposase activity
FR761_RS12030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FR761_RS12035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR761_RS12045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FR761_RS12070	COG0305	Participates in initiation and elongation during chromosome replication
FR761_RS12075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR761_RS12085	COG1305	Transglutaminase-like
FR761_RS12095	COG2308	Evidence 4 Homologs of previously reported genes of
FR761_RS12125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FR761_RS12130	COG0138	bifunctional purine biosynthesis protein purh
FR761_RS12135	COG0151	Belongs to the GarS family
FR761_RS12140	COG1464	Belongs to the NlpA lipoprotein family
FR761_RS12145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR761_RS12150	COG2011	ABC-type metal ion transport system permease component
FR761_RS12155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR761_RS12165	COG1301	dicarboxylic acid transport
FR761_RS12195	COG1794	racemase activity, acting on amino acids and derivatives
FR761_RS12205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR761_RS12205	COG3008	intermembrane lipid transfer
FR761_RS12210	COG2995	paraquat-inducible protein a
FR761_RS12310	COG2186	Transcriptional regulator
FR761_RS12320	COG0786	glutamate:sodium symporter activity
FR761_RS12325	COG3243	poly(R)-hydroxyalkanoic acid synthase
FR761_RS12410	COG0515	serine threonine protein kinase
FR761_RS12410	COG2815	serine threonine protein kinase
FR761_RS12440	COG1610	YqeY-like protein
FR761_RS12445	COG4783	chaperone-mediated protein folding
FR761_RS12470	COG1286	toxin biosynthetic process
FR761_RS12500	COG0778	Nitroreductase
FR761_RS12510	COG0513	Belongs to the DEAD box helicase family
FR761_RS12530	COG2363	Small membrane protein
FR761_RS12560	COG4650	regulator
FR761_RS12565	COG1234	tRNA 3'-trailer cleavage
FR761_RS12570	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR761_RS12580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FR761_RS12590	COG2819	hydrolase of the alpha beta superfamily
FR761_RS12595	COG1960	acyl-CoA dehydrogenase activity
FR761_RS12600	COG1301	dicarboxylic acid transport
FR761_RS12610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FR761_RS12615	COG3139	Protein of unknown function (DUF1315)
FR761_RS12620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FR761_RS12625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR761_RS12635	COG0494	nUDIX hydrolase
FR761_RS12645	COG0642	Histidine kinase
FR761_RS12660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR761_RS12670	COG1720	tRNA m6t6A37 methyltransferase activity
FR761_RS12685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR761_RS12690	COG0826	peptidase U32
FR761_RS12695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR761_RS12705	COG4598	ABC transporter
FR761_RS12710	COG4160	amino acid transport
FR761_RS12715	COG4215	(ABC) transporter
FR761_RS12730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS12775	COG1131	(ABC) transporter
FR761_RS12780	COG0842	Transport permease protein
FR761_RS12795	COG0772	Belongs to the SEDS family
FR761_RS12800	COG2951	lytic endotransglycosylase activity
FR761_RS12825	COG2207	Transcriptional regulator
FR761_RS12840	COG0052	Belongs to the universal ribosomal protein uS2 family
FR761_RS12845	COG0024	Methionine aminopeptidase
FR761_RS12860	COG2223	nitrite transmembrane transporter activity
FR761_RS12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR761_RS12875	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR761_RS12880	COG1960	acyl-CoA dehydrogenase activity
FR761_RS12895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FR761_RS12900	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FR761_RS12905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR761_RS12925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR761_RS12930	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FR761_RS12935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FR761_RS12970	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FR761_RS12980	COG0174	glutamine synthetase
FR761_RS13005	COG0512	Glutamine amidotransferase of anthranilate synthase
FR761_RS13010	COG0308	aminopeptidase N
FR761_RS13040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FR761_RS13050	COG0302	gtp cyclohydrolase
FR761_RS13070	COG3739	integral membrane protein
FR761_RS13100	COG1132	(ABC) transporter
FR761_RS13105	COG1132	(ABC) transporter
FR761_RS13120	COG3433	isochorismatase activity
FR761_RS13120	COG1535	isochorismatase
FR761_RS13125	COG1021	2,3-dihydroxybenzoate-AMP ligase
FR761_RS13130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR761_RS13140	COG4774	siderophore transport
FR761_RS13145	COG4607	ABC-type enterochelin transport system periplasmic component
FR761_RS13150	COG4604	ABC transporter, ATP-binding protein
FR761_RS13155	COG4605	iron ion homeostasis
FR761_RS13160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR761_RS13165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR761_RS13180	COG2964	Protein conserved in bacteria
FR761_RS13190	COG1741	Belongs to the pirin family
FR761_RS13320	COG0582	viral genome integration into host DNA
FR761_RS13330	COG2879	small protein
FR761_RS13335	COG1966	Carbon starvation protein
FR761_RS13380	COG1067	ATP-dependent peptidase activity
FR761_RS13385	COG0583	DNA-binding transcription factor activity
FR761_RS13410	COG1686	Belongs to the peptidase S11 family
FR761_RS13415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FR761_RS13450	COG0616	signal peptide processing
FR761_RS13455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR761_RS13465	COG0573	inorganic phosphate transmembrane transporter activity
FR761_RS13470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FR761_RS13475	COG1113	amino acid transport
FR761_RS13480	COG3961	Belongs to the TPP enzyme family
FR761_RS13485	COG1522	sequence-specific DNA binding
FR761_RS13495	COG0076	glutamate decarboxylase activity
FR761_RS13500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR761_RS13510	COG1309	transcriptional regulator
FR761_RS13525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR761_RS13560	COG0352	thiamine-phosphate diphosphorylase activity
FR761_RS13585	COG1203	CRISPR-associated helicase, Cas3
FR761_RS13615	COG0612	Peptidase, M16
FR761_RS13625	COG1823	symporter activity
FR761_RS13630	COG0583	DNA-binding transcription factor activity
FR761_RS13635	COG0477	Major facilitator Superfamily
FR761_RS13660	COG0582	viral genome integration into host DNA
FR761_RS13800	COG3566	protein conserved in bacteria
FR761_RS13815	COG3567	Phage-associated protein, HI1409 family
FR761_RS13820	COG5410	chromosome segregation
FR761_RS14005	COG1187	pseudouridine synthase activity
FR761_RS14020	COG1686	Belongs to the peptidase S11 family
FR761_RS14025	COG1252	NADH dehydrogenase
FR761_RS14035	COG0415	Belongs to the DNA photolyase family
FR761_RS14050	COG1215	transferase activity, transferring glycosyl groups
FR761_RS14080	COG2070	2-Nitropropane dioxygenase
FR761_RS14135	COG0556	nucleotide-excision repair
FR761_RS14155	COG0436	Aminotransferase
FR761_RS14185	COG4221	oxidoreductase activity
FR761_RS14195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FR761_RS14200	COG1381	Involved in DNA repair and RecF pathway recombination
FR761_RS14210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FR761_RS14225	COG0681	Belongs to the peptidase S26 family
FR761_RS14235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR761_RS14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR761_RS14265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FR761_RS14270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FR761_RS14275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FR761_RS14285	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FR761_RS14290	COG4208	sulfate ABC transporter
FR761_RS14295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FR761_RS14300	COG0583	DNA-binding transcription factor activity
FR761_RS14305	COG4625	pathogenesis
FR761_RS14320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FR761_RS14335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FR761_RS14340	COG3328	transposase activity
FR761_RS14350	COG1051	belongs to the nudix hydrolase family
FR761_RS14350	COG1056	cytidyltransferase-related domain
FR761_RS14355	COG1024	Enoyl-CoA hydratase
FR761_RS14365	COG2814	Major facilitator Superfamily
FR761_RS14370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FR761_RS14370	COG0047	phosphoribosylformylglycinamidine synthase activity
FR761_RS14390	COG1473	amidohydrolase
FR761_RS14395	COG0824	Thioesterase
FR761_RS14415	COG0823	Involved in the tonB-independent uptake of proteins
FR761_RS14435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR761_RS14475	COG0628	permease
FR761_RS14485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FR761_RS14490	COG0596	Alpha beta hydrolase
FR761_RS14495	COG0616	signal peptide processing
FR761_RS14495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR761_RS14505	COG0658	competence protein
FR761_RS14505	COG2333	competence protein COMEC
FR761_RS14510	COG1136	(ABC) transporter
FR761_RS14515	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR761_RS14545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS14565	COG0463	Glycosyl transferase, family 2
FR761_RS14595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FR761_RS14600	COG1280	lysine exporter protein (LysE YggA)
FR761_RS14610	COG0019	diaminopimelate decarboxylase activity
FR761_RS14620	COG1113	amino acid transport
FR761_RS14635	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FR761_RS14645	COG3339	Conserved Protein
FR761_RS14650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR761_RS14655	COG0243	molybdopterin cofactor binding
FR761_RS14660	COG1929	Belongs to the glycerate kinase type-1 family
FR761_RS14670	COG0300	oxidoreductase activity
FR761_RS14675	COG0778	Nitroreductase
FR761_RS14710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR761_RS14715	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS14730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR761_RS14755	COG0741	lytic transglycosylase activity
FR761_RS14775	COG0584	glycerophosphoryl diester phosphodiesterase
FR761_RS14780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR761_RS14790	COG0582	viral genome integration into host DNA
FR761_RS14795	COG1074	ATP-dependent DNA helicase activity
FR761_RS14815	COG1230	cation diffusion facilitator family transporter
FR761_RS14830	COG2814	Major facilitator Superfamily
FR761_RS14940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FR761_RS14945	COG1597	lipid kinase activity
FR761_RS14960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FR761_RS14965	COG0477	Major facilitator Superfamily
FR761_RS15015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FR761_RS15020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR761_RS15045	COG0505	Belongs to the CarA family
FR761_RS15060	COG1309	transcriptional regulator
FR761_RS15065	COG0251	oxidation-reduction process
FR761_RS15075	COG0589	response to stress
FR761_RS15090	COG2843	Capsule synthesis protein
FR761_RS15100	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS15105	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FR761_RS15130	COG2321	neutral zinc metallopeptidase
FR761_RS15135	COG2354	Protein conserved in bacteria
FR761_RS15155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR761_RS15180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR761_RS15185	COG1053	succinate dehydrogenase
FR761_RS15190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FR761_RS15195	COG2009	succinate dehydrogenase
FR761_RS15230	COG2921	Belongs to the UPF0250 family
FR761_RS15235	COG0321	lipoyl(octanoyl) transferase activity
FR761_RS15250	COG0531	amino acid
FR761_RS15260	COG1733	regulation of RNA biosynthetic process
FR761_RS15265	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FR761_RS15270	COG1648	precorrin-2 dehydrogenase activity
FR761_RS15270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FR761_RS15285	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FR761_RS15315	COG0671	phosphoesterase, PA-phosphatase related
FR761_RS15320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR761_RS15330	COG1538	Outer membrane efflux protein
FR761_RS15335	COG0393	Putative heavy-metal-binding
FR761_RS15340	COG0393	Putative heavy-metal-binding
FR761_RS15350	COG1028	Short-chain dehydrogenase reductase Sdr
FR761_RS15360	COG0525	valine-tRNA ligase activity
FR761_RS15385	COG0583	DNA-binding transcription factor activity
FR761_RS15395	COG0004	ammonium transporteR
FR761_RS15405	COG0642	Histidine kinase
FR761_RS15410	COG0745	RESPONSE REGULATOR receiver
FR761_RS15415	COG2194	sulfuric ester hydrolase activity
FR761_RS15435	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR761_RS15450	COG2315	Protein conserved in bacteria
FR761_RS15455	COG0142	geranyltranstransferase activity
FR761_RS15460	COG2828	Protein conserved in bacteria
FR761_RS15465	COG1113	amino acid transport
FR761_RS15475	COG0582	viral genome integration into host DNA
FR761_RS15520	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS15555	COG2207	Transcriptional regulator
FR761_RS15580	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR761_RS15600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FR761_RS15610	COG1530	ribonuclease E activity
FR761_RS15615	COG0424	maF-like protein
FR761_RS15620	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FR761_RS15625	COG1792	Involved in formation and maintenance of cell shape
FR761_RS15630	COG1077	Cell shape determining protein MreB Mrl
FR761_RS15635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FR761_RS15645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FR761_RS15665	COG3590	peptidase
FR761_RS15670	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FR761_RS15675	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FR761_RS15680	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR761_RS15685	COG1115	amino acid carrier protein
FR761_RS15705	COG2814	Major facilitator Superfamily
FR761_RS15710	COG1289	transmembrane transporter activity
FR761_RS15720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR761_RS15760	COG1376	ErfK ybiS ycfS ynhG family protein
FR761_RS15765	COG2832	Protein of unknown function (DUF454)
FR761_RS15775	COG5510	response to toxic substance
FR761_RS15795	COG0840	transmembrane signaling receptor activity
FR761_RS15835	COG3422	double-strand break repair
FR761_RS15840	COG2824	Alkylphosphonate utilization operon protein PhnA
FR761_RS15845	COG3189	MarR family transcriptional regulator
FR761_RS15855	COG0354	folic acid binding
FR761_RS15860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR761_RS15890	COG1902	pentaerythritol trinitrate reductase activity
FR761_RS15895	COG4772	TonB-dependent receptor
FR761_RS15900	COG2094	Belongs to the DNA glycosylase MPG family
FR761_RS15925	COG1217	gtp-binding protein TYPA
FR761_RS15930	COG2233	PERMEase
FR761_RS15940	COG0833	amino acid
FR761_RS15945	COG1690	Belongs to the RtcB family
FR761_RS15950	COG2885	chlorophyll binding
FR761_RS15950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FR761_RS15960	COG0183	Belongs to the thiolase family
FR761_RS15980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR761_RS16000	COG2207	Transcriptional regulator
FR761_RS16005	COG0183	Belongs to the thiolase family
FR761_RS16035	COG1272	protein, Hemolysin III
FR761_RS16040	COG0477	Major facilitator Superfamily
FR761_RS16055	COG0450	alkyl hydroperoxide reductase
FR761_RS16075	COG0285	dihydrofolate synthase activity
FR761_RS16125	COG2096	Adenosyltransferase
FR761_RS16130	COG0584	glycerophosphoryl diester phosphodiesterase
FR761_RS16145	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FR761_RS16150	COG0745	RESPONSE REGULATOR receiver
FR761_RS16155	COG2205	protein histidine kinase activity
FR761_RS16165	COG1960	acyl-CoA dehydrogenase activity
FR761_RS16170	COG1960	acyl-CoA dehydrogenase activity
FR761_RS16220	COG1442	glycosyl transferase family 8
FR761_RS16230	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS16265	COG0438	transferase activity, transferring glycosyl groups
FR761_RS16275	COG0438	transferase activity, transferring glycosyl groups
FR761_RS16280	COG0726	polysaccharide deacetylase
FR761_RS16295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FR761_RS16300	COG2205	protein histidine kinase activity
FR761_RS16310	COG3646	Phage regulatory protein
FR761_RS16340	COG4695	Portal protein
FR761_RS16480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FR761_RS16490	COG3646	Phage regulatory protein
FR761_RS16530	COG0629	single-stranded DNA binding
FR761_RS16595	COG1862	Preprotein translocase
FR761_RS16605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR761_RS16610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FR761_RS16620	COG3781	membrane
FR761_RS16625	COG0613	PHP domain protein
FR761_RS16635	COG2350	Protein conserved in bacteria
FR761_RS16665	COG1607	acyl-coa hydrolase
FR761_RS16690	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS16730	COG2199	diguanylate cyclase activity
FR761_RS16740	COG1408	metallophosphoesterase
FR761_RS16745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR761_RS16755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FR761_RS16775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FR761_RS16780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FR761_RS16785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FR761_RS16795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FR761_RS16805	COG2969	positive regulation of protein catabolic process
FR761_RS16825	COG1960	acyl-CoA dehydrogenase activity
FR761_RS16830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR761_RS16845	COG1309	transcriptional regulator
FR761_RS16850	COG1960	acyl-CoA dehydrogenase activity
FR761_RS16895	COG1183	phosphatidylcholine synthase activity
FR761_RS16900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FR761_RS16930	COG1196	nuclear chromosome segregation
FR761_RS16930	COG0739	heme binding
FR761_RS16930	COG0741	lytic transglycosylase activity
FR761_RS16940	COG1702	phosphate starvation-inducible protein PhoH
FR761_RS16975	COG1295	ribonuclease BN
FR761_RS16980	COG0697	spore germination
FR761_RS16985	COG2169	Transcriptional regulator
FR761_RS16990	COG0179	Fumarylacetoacetate (FAA) hydrolase
FR761_RS17035	COG0557	exoribonuclease II activity
FR761_RS17040	COG0339	signal peptide processing
FR761_RS17045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FR761_RS17075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FR761_RS17260	COG0626	cystathionine gamma-synthase activity
FR761_RS17265	COG0433	COG0433 Predicted ATPase
FR761_RS17275	COG1017	nitric oxide dioxygenase activity
FR761_RS17275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR761_RS17280	COG1959	2 iron, 2 sulfur cluster binding
FR761_RS17295	COG1301	dicarboxylic acid transport
FR761_RS17300	COG1946	Acyl-CoA thioesterase
FR761_RS17320	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FR761_RS17325	COG1040	competence protein
FR761_RS17330	COG0494	nUDIX hydrolase
FR761_RS17340	COG0598	Magnesium transport protein CorA
FR761_RS17350	COG2854	intermembrane phospholipid transfer
FR761_RS17360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FR761_RS17365	COG1127	ABC transporter
FR761_RS17375	COG0513	Belongs to the DEAD box helicase family
FR761_RS17395	COG0408	coproporphyrinogen oxidase activity
FR761_RS17410	COG1960	acyl-CoA dehydrogenase activity
FR761_RS17420	COG1983	PspC domain protein
FR761_RS17425	COG0517	IMP dehydrogenase activity
FR761_RS17470	COG0583	DNA-binding transcription factor activity
FR761_RS17510	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS17520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR761_RS17525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR761_RS17530	COG0833	amino acid
FR761_RS17560	COG1192	Involved in chromosome partitioning
FR761_RS17565	COG0628	permease
FR761_RS17575	COG1289	transmembrane transporter activity
FR761_RS17590	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR761_RS17595	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FR761_RS17605	COG0277	FAD linked oxidase domain protein
FR761_RS17610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR761_RS17635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FR761_RS17640	COG5380	lipid catabolic process
FR761_RS17660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FR761_RS17710	COG0194	GDP metabolic process
FR761_RS17725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR761_RS17745	COG3307	-O-antigen
FR761_RS17755	COG4969	Belongs to the N-Me-Phe pilin family
FR761_RS17765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FR761_RS17770	COG1704	LemA family
FR761_RS17780	COG0493	'glutamate synthase
FR761_RS17785	COG0067	glutamate synthase
FR761_RS17785	COG0069	glutamate synthase activity
FR761_RS17785	COG0070	glutamate synthase
FR761_RS17835	COG2226	methyltransferase
FR761_RS17850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FR761_RS17855	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FR761_RS17900	COG0833	amino acid
FR761_RS17920	COG0582	viral genome integration into host DNA
FR761_RS17930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FR761_RS17940	COG2826	transposase and inactivated derivatives, IS30 family
FR761_RS18050	COG3293	Transposase
FR761_RS18085	COG0488	(ABC) transporter
FR761_RS18090	COG2873	o-acetylhomoserine
FR761_RS18095	COG4221	oxidoreductase activity
FR761_RS18100	COG0659	secondary active sulfate transmembrane transporter activity
FR761_RS18125	COG0427	acetyl-CoA hydrolase
FR761_RS18155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FR761_RS18195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR761_RS18250	COG0582	viral genome integration into host DNA
FR761_RS18340	COG0667	Aldo Keto reductase
FR761_RS18360	COG0583	DNA-binding transcription factor activity
FR761_RS18365	COG2814	Major facilitator Superfamily
FR761_RS18395	COG1335	isochorismatase
FR761_RS18405	COG1012	belongs to the aldehyde dehydrogenase family
FR761_RS18410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR761_RS18420	COG1113	amino acid transport
FR761_RS18430	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FR761_RS18445	COG2814	Major facilitator Superfamily
FR761_RS18455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR761_RS18455	COG0352	thiamine-phosphate diphosphorylase activity
FR761_RS18455	COG0351	phosphomethylpyrimidine kinase
FR761_RS18475	COG1309	transcriptional regulator
FR761_RS18480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FR761_RS18495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR761_RS18505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR761_RS18510	COG3162	membrane
FR761_RS18515	COG2205	protein histidine kinase activity
FR761_RS18515	COG2198	Histidine kinase
FR761_RS18515	COG0784	Response regulator, receiver
FR761_RS18540	COG1522	sequence-specific DNA binding
FR761_RS18545	COG1335	isochorismatase
FR761_RS18550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR761_RS18570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FR761_RS18580	COG3657	addiction module killer protein
FR761_RS18585	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR761_RS18595	COG2801	Transposase and inactivated derivatives
FR761_RS18605	COG0659	secondary active sulfate transmembrane transporter activity
FR761_RS18640	COG2801	Transposase and inactivated derivatives
FR761_RS18660	COG3657	addiction module killer protein
FR761_RS18665	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR761_RS18670	COG0488	(ABC) transporter
FR761_RS18675	COG3173	Aminoglycoside phosphotransferase
FR761_RS18685	COG2801	Transposase and inactivated derivatives
FR761_RS18715	COG0745	RESPONSE REGULATOR receiver
FR761_RS18725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR761_RS18730	COG1538	Outer membrane efflux protein
FR761_RS18790	COG3971	2-oxopent-4-enoate hydratase activity
FR761_RS18795	COG4569	acetaldehyde dehydrogenase (acetylating) activity
FR761_RS18800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR761_RS18805	COG0179	Fumarylacetoacetate (FAA) hydrolase
FR761_RS18865	COG1660	Displays ATPase and GTPase activities
FR761_RS18925	COG4977	sequence-specific DNA binding
FR761_RS18935	COG0583	DNA-binding transcription factor activity
FR761_RS18945	COG4941	Belongs to the sigma-70 factor family
FR761_RS18950	COG3795	YCII-related domain
FR761_RS18985	COG0534	Mate efflux family protein
FR761_RS18990	COG4106	trans-aconitate 2-methyltransferase activity
FR761_RS18995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FR761_RS19005	COG1131	(ABC) transporter
FR761_RS19045	COG0860	N-Acetylmuramoyl-L-alanine amidase
FR761_RS19155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR761_RS19200	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FR761_RS19210	COG1525	nuclease
FR761_RS19265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR761_RS19370	COG2197	response regulator
FR761_RS19380	COG0154	amidase activity
FR761_RS19385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR761_RS19505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR761_RS19585	COG4372	Transposase
FR761_RS19720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FR761_RS19895	COG1475	DNA binding
FR761_RS19900	COG1192	Involved in chromosome partitioning
FR761_RS20210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR761_RS20240	COG0582	viral genome integration into host DNA
FR761_RS20255	COG1373	ATPase (AAA superfamily
FR761_RS20260	COG4680	protein conserved in bacteria
FR761_RS20305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FR761_RS20310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR761_RS20335	COG0697	spore germination
FR761_RS20355	COG0804	urea catabolic process
FR761_RS20365	COG0831	urea catabolic process
FR761_RS20370	COG0829	nickel cation binding
FR761_RS20385	COG0830	nickel cation binding
FR761_RS20405	COG1475	DNA binding
FR761_RS20410	COG1192	Involved in chromosome partitioning
FR761_RS20470	COG0583	DNA-binding transcription factor activity
FR761_RS20595	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
FR761_RS20690	COG2076	Multidrug Resistance protein
FR761_RS20765	COG2337	Toxic component of a toxin-antitoxin (TA) module
FR761_RS20770	COG2336	PFAM SpoVT AbrB