locus-tag	class	description
I6H93_RS00005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H93_RS00010	COG2070	2-Nitropropane dioxygenase
I6H93_RS00040	COG1215	transferase activity, transferring glycosyl groups
I6H93_RS00055	COG0415	Belongs to the DNA photolyase family
I6H93_RS00065	COG1252	NADH dehydrogenase
I6H93_RS00070	COG1686	Belongs to the peptidase S11 family
I6H93_RS00085	COG1187	pseudouridine synthase activity
I6H93_RS00110	COG0477	Major facilitator Superfamily
I6H93_RS00115	COG0583	DNA-binding transcription factor activity
I6H93_RS00120	COG1823	symporter activity
I6H93_RS00130	COG0612	Peptidase, M16
I6H93_RS00160	COG1203	CRISPR-associated helicase, Cas3
I6H93_RS00185	COG0352	thiamine-phosphate diphosphorylase activity
I6H93_RS00220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H93_RS00235	COG1309	transcriptional regulator
I6H93_RS00245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6H93_RS00250	COG0076	glutamate decarboxylase activity
I6H93_RS00260	COG1522	sequence-specific DNA binding
I6H93_RS00265	COG3961	Belongs to the TPP enzyme family
I6H93_RS00270	COG1113	amino acid transport
I6H93_RS00275	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H93_RS00280	COG0573	inorganic phosphate transmembrane transporter activity
I6H93_RS00290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H93_RS00295	COG0616	signal peptide processing
I6H93_RS00330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6H93_RS00335	COG1686	Belongs to the peptidase S11 family
I6H93_RS00360	COG0583	DNA-binding transcription factor activity
I6H93_RS00365	COG1067	ATP-dependent peptidase activity
I6H93_RS00390	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6H93_RS00410	COG1966	Carbon starvation protein
I6H93_RS00415	COG2879	small protein
I6H93_RS00425	COG0583	DNA-binding transcription factor activity
I6H93_RS00430	COG0006	proline dipeptidase activity
I6H93_RS00435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H93_RS00440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H93_RS00450	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS00455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H93_RS00460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6H93_RS00460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H93_RS00520	COG1741	Belongs to the pirin family
I6H93_RS00530	COG2964	Protein conserved in bacteria
I6H93_RS00545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H93_RS00550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H93_RS00555	COG4605	iron ion homeostasis
I6H93_RS00560	COG4604	ABC transporter, ATP-binding protein
I6H93_RS00565	COG4607	ABC-type enterochelin transport system periplasmic component
I6H93_RS00570	COG4774	siderophore transport
I6H93_RS00580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H93_RS00585	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6H93_RS00590	COG1535	isochorismatase
I6H93_RS00590	COG3433	isochorismatase activity
I6H93_RS00605	COG1132	(ABC) transporter
I6H93_RS00610	COG1132	(ABC) transporter
I6H93_RS00615	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6H93_RS00625	COG1169	isochorismate synthase
I6H93_RS00640	COG3739	integral membrane protein
I6H93_RS00660	COG0302	gtp cyclohydrolase
I6H93_RS00670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6H93_RS00700	COG0308	aminopeptidase N
I6H93_RS00705	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H93_RS00720	COG0174	glutamine synthetase
I6H93_RS00730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6H93_RS00765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H93_RS00770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6H93_RS00775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H93_RS00800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H93_RS00805	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H93_RS00810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6H93_RS00825	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS00830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H93_RS00835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H93_RS00845	COG2223	nitrite transmembrane transporter activity
I6H93_RS00855	COG0024	Methionine aminopeptidase
I6H93_RS00860	COG0052	Belongs to the universal ribosomal protein uS2 family
I6H93_RS00875	COG2207	Transcriptional regulator
I6H93_RS00900	COG2951	lytic endotransglycosylase activity
I6H93_RS00905	COG0772	Belongs to the SEDS family
I6H93_RS00920	COG0842	Transport permease protein
I6H93_RS00925	COG1131	(ABC) transporter
I6H93_RS00930	COG0582	viral genome integration into host DNA
I6H93_RS00970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H93_RS01030	COG0305	Participates in initiation and elongation during chromosome replication
I6H93_RS01130	COG5410	chromosome segregation
I6H93_RS01250	COG0739	heme binding
I6H93_RS01355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS01370	COG4215	(ABC) transporter
I6H93_RS01375	COG4160	amino acid transport
I6H93_RS01390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H93_RS01395	COG0826	peptidase U32
I6H93_RS01400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H93_RS01415	COG1720	tRNA m6t6A37 methyltransferase activity
I6H93_RS01425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H93_RS01440	COG0642	Histidine kinase
I6H93_RS01450	COG0494	nUDIX hydrolase
I6H93_RS01460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H93_RS01465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6H93_RS01470	COG3139	Protein of unknown function (DUF1315)
I6H93_RS01475	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6H93_RS01480	COG1301	dicarboxylic acid transport
I6H93_RS01485	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS01490	COG2819	hydrolase of the alpha beta superfamily
I6H93_RS01500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H93_RS01510	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H93_RS01515	COG1234	tRNA 3'-trailer cleavage
I6H93_RS01540	COG2363	Small membrane protein
I6H93_RS01560	COG0513	Belongs to the DEAD box helicase family
I6H93_RS01570	COG0778	Nitroreductase
I6H93_RS01600	COG1286	toxin biosynthetic process
I6H93_RS01625	COG4783	chaperone-mediated protein folding
I6H93_RS01630	COG1610	YqeY-like protein
I6H93_RS01730	COG3111	PFAM Bacterial OB fold (BOF) protein
I6H93_RS01755	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6H93_RS01760	COG0786	glutamate:sodium symporter activity
I6H93_RS01770	COG0583	DNA-binding transcription factor activity
I6H93_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS01795	COG2186	Transcriptional regulator
I6H93_RS01855	COG0477	Major facilitator Superfamily
I6H93_RS01880	COG2995	paraquat-inducible protein a
I6H93_RS01885	COG3008	intermembrane lipid transfer
I6H93_RS01885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6H93_RS01895	COG2351	hydroxyisourate hydrolase activity
I6H93_RS01935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H93_RS01945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6H93_RS01950	COG0642	Histidine kinase
I6H93_RS01955	COG0745	RESPONSE REGULATOR receiver
I6H93_RS01975	COG1794	racemase activity, acting on amino acids and derivatives
I6H93_RS02005	COG1301	dicarboxylic acid transport
I6H93_RS02015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H93_RS02020	COG2011	ABC-type metal ion transport system permease component
I6H93_RS02025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H93_RS02030	COG1464	Belongs to the NlpA lipoprotein family
I6H93_RS02035	COG0151	Belongs to the GarS family
I6H93_RS02040	COG0138	bifunctional purine biosynthesis protein purh
I6H93_RS02045	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6H93_RS02075	COG2308	Evidence 4 Homologs of previously reported genes of
I6H93_RS02085	COG1305	Transglutaminase-like
I6H93_RS02095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6H93_RS02100	COG0305	Participates in initiation and elongation during chromosome replication
I6H93_RS02125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6H93_RS02135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6H93_RS02140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6H93_RS02165	COG0726	polysaccharide deacetylase
I6H93_RS02165	COG1649	PFAM Uncharacterised BCR, COG1649
I6H93_RS02170	COG1215	transferase activity, transferring glycosyl groups
I6H93_RS02175	COG3658	cytochrome
I6H93_RS02185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H93_RS02200	COG0583	DNA-binding transcription factor activity
I6H93_RS02220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H93_RS02225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H93_RS02240	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS02245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H93_RS02250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS02275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6H93_RS02280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6H93_RS02290	COG2205	protein histidine kinase activity
I6H93_RS02295	COG0745	RESPONSE REGULATOR receiver
I6H93_RS02300	COG0174	glutamine synthetase
I6H93_RS02320	COG0729	surface antigen
I6H93_RS02345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H93_RS02350	COG2814	Major facilitator Superfamily
I6H93_RS02365	COG0583	DNA-binding transcription factor activity
I6H93_RS02380	COG1187	pseudouridine synthase activity
I6H93_RS02400	COG0802	atpase or kinase
I6H93_RS02405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6H93_RS02415	COG1923	regulation of RNA biosynthetic process
I6H93_RS02420	COG0697	spore germination
I6H93_RS02445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H93_RS02450	COG0519	Catalyzes the synthesis of GMP from XMP
I6H93_RS02450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H93_RS02455	COG4302	ethanolamine ammonia-lyase activity
I6H93_RS02460	COG4303	Ethanolamine ammonia lyase large subunit
I6H93_RS02465	COG0531	amino acid
I6H93_RS02485	COG1454	alcohol dehydrogenase
I6H93_RS02490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H93_RS02515	COG0308	aminopeptidase N
I6H93_RS02555	COG1605	Chorismate mutase
I6H93_RS02570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H93_RS02585	COG1309	transcriptional regulator
I6H93_RS02595	COG0668	transmembrane transport
I6H93_RS02625	COG4773	Receptor
I6H93_RS02645	COG0488	(ABC) transporter
I6H93_RS02650	COG0589	response to stress
I6H93_RS02710	COG3135	benzoate transporter
I6H93_RS02715	COG1522	sequence-specific DNA binding
I6H93_RS02725	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H93_RS02730	COG0583	DNA-binding transcription factor activity
I6H93_RS02740	COG0183	Belongs to the thiolase family
I6H93_RS02750	COG2030	dehydratase
I6H93_RS02755	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H93_RS02770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H93_RS02780	COG0824	Thioesterase
I6H93_RS02785	COG1454	alcohol dehydrogenase
I6H93_RS02795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H93_RS02815	COG0069	glutamate synthase activity
I6H93_RS02835	COG2814	Major facilitator Superfamily
I6H93_RS02850	COG0511	ligase activity, forming carbon-carbon bonds
I6H93_RS02870	COG1116	anion transmembrane transporter activity
I6H93_RS02870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H93_RS02875	COG0745	RESPONSE REGULATOR receiver
I6H93_RS02885	COG2146	nitrite reductase [NAD(P)H] activity
I6H93_RS02885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H93_RS02890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H93_RS02895	COG0243	molybdopterin cofactor binding
I6H93_RS02905	COG0243	molybdopterin cofactor binding
I6H93_RS02910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6H93_RS02925	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6H93_RS02925	COG0315	cyclic pyranopterin monophosphate synthase activity
I6H93_RS02930	COG0303	'Molybdopterin
I6H93_RS02945	COG0697	spore germination
I6H93_RS02965	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6H93_RS02970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H93_RS03025	COG2204	response regulator
I6H93_RS03030	COG3852	Histidine kinase
I6H93_RS03055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H93_RS03060	COG0575	Belongs to the CDS family
I6H93_RS03095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H93_RS03110	COG2137	regulation of response to DNA damage stimulus
I6H93_RS03120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H93_RS03125	COG1011	Hydrolase
I6H93_RS03150	COG1522	sequence-specific DNA binding
I6H93_RS03160	COG1113	amino acid transport
I6H93_RS03175	COG0659	secondary active sulfate transmembrane transporter activity
I6H93_RS03180	COG2135	peptidase activity
I6H93_RS03195	COG3300	MHYT domain
I6H93_RS03195	COG5001	Diguanylate cyclase
I6H93_RS03215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6H93_RS03215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H93_RS03215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H93_RS03220	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H93_RS03225	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H93_RS03225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H93_RS03255	COG0024	Methionine aminopeptidase
I6H93_RS03260	COG0583	DNA-binding transcription factor activity
I6H93_RS03270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6H93_RS03275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H93_RS03280	COG0516	GMP reductase activity
I6H93_RS03280	COG0517	IMP dehydrogenase activity
I6H93_RS03305	COG0552	protein localization to endoplasmic reticulum
I6H93_RS03315	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6H93_RS03325	COG4890	Cyd operon protein YbgT
I6H93_RS03330	COG1294	oxidase, subunit
I6H93_RS03345	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6H93_RS03355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H93_RS03360	COG4774	siderophore transport
I6H93_RS03375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H93_RS03380	COG0569	domain protein
I6H93_RS03385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H93_RS03415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6H93_RS03420	COG0542	response to heat
I6H93_RS03445	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H93_RS03445	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS03490	COG2323	membrane
I6H93_RS03495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6H93_RS03505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H93_RS03510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H93_RS03515	COG0183	Belongs to the thiolase family
I6H93_RS03520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H93_RS03525	COG0596	Alpha beta hydrolase
I6H93_RS03530	COG2271	Major facilitator Superfamily
I6H93_RS03535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H93_RS03540	COG3485	protocatechuate 3,4-dioxygenase
I6H93_RS03545	COG3485	protocatechuate 3,4-dioxygenase
I6H93_RS03550	COG0710	3-dehydroquinate dehydratase activity
I6H93_RS03555	COG3420	alginic acid biosynthetic process
I6H93_RS03560	COG3659	wide pore channel activity
I6H93_RS03565	COG4993	Dehydrogenase
I6H93_RS03575	COG2391	methyltransferase activity
I6H93_RS03590	COG1414	Transcriptional regulator
I6H93_RS03595	COG0583	DNA-binding transcription factor activity
I6H93_RS03600	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS03625	COG2814	Major facilitator Superfamily
I6H93_RS03635	COG0154	amidase activity
I6H93_RS03655	COG4638	Rieske (2fe-2S)
I6H93_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS03675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS03685	COG3733	amine oxidase
I6H93_RS03695	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS03705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H93_RS03710	COG0183	Belongs to the thiolase family
I6H93_RS03715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H93_RS03720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H93_RS03730	COG4829	muconolactone delta-isomerase
I6H93_RS03735	COG4948	Mandelate Racemase Muconate Lactonizing
I6H93_RS03740	COG0583	DNA-binding transcription factor activity
I6H93_RS03750	COG2186	Transcriptional regulator
I6H93_RS03770	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS03785	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS03785	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H93_RS03825	COG1309	transcriptional regulator
I6H93_RS03835	COG4221	oxidoreductase activity
I6H93_RS03840	COG4689	acetoacetate decarboxylase
I6H93_RS03850	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS03870	COG1335	isochorismatase
I6H93_RS03875	COG0583	DNA-binding transcription factor activity
I6H93_RS03885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H93_RS03885	COG0475	glutathione-regulated potassium exporter activity
I6H93_RS03895	COG1473	amidohydrolase
I6H93_RS03955	COG2188	Transcriptional regulator
I6H93_RS03970	COG0583	DNA-binding transcription factor activity
I6H93_RS03985	COG1566	PFAM secretion protein HlyD family protein
I6H93_RS04000	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS04005	COG0129	dihydroxy-acid dehydratase activity
I6H93_RS04015	COG0583	DNA-binding transcription factor activity
I6H93_RS04020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6H93_RS04030	COG2084	Dehydrogenase
I6H93_RS04045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H93_RS04105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6H93_RS04120	COG0556	nucleotide-excision repair
I6H93_RS04155	COG1073	alpha beta
I6H93_RS04165	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS04180	COG2207	Transcriptional regulator
I6H93_RS04190	COG2205	protein histidine kinase activity
I6H93_RS04195	COG0745	RESPONSE REGULATOR receiver
I6H93_RS04200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS04205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H93_RS04210	COG1538	Outer membrane efflux protein
I6H93_RS04220	COG2072	flavoprotein involved in K transport
I6H93_RS04230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H93_RS04465	COG3539	Fimbrial protein
I6H93_RS04490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6H93_RS04500	COG0753	catalase activity
I6H93_RS04515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H93_RS04575	COG1535	isochorismatase
I6H93_RS04575	COG3433	isochorismatase activity
I6H93_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS04585	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6H93_RS04590	COG4149	molybdate abc transporter
I6H93_RS04595	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6H93_RS04605	COG4638	Rieske (2fe-2S)
I6H93_RS04610	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6H93_RS04615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H93_RS04615	COG0543	2 iron, 2 sulfur cluster binding
I6H93_RS04630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS04655	COG2207	Transcriptional regulator
I6H93_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS04665	COG2610	gluconate transmembrane transporter activity
I6H93_RS04675	COG0583	DNA-binding transcription factor activity
I6H93_RS04690	COG2031	fatty acid transporter
I6H93_RS04695	COG0183	Belongs to the thiolase family
I6H93_RS04700	COG0583	DNA-binding transcription factor activity
I6H93_RS04705	COG0583	DNA-binding transcription factor activity
I6H93_RS04720	COG1027	Aspartate ammonia-lyase
I6H93_RS04730	COG0477	Major facilitator Superfamily
I6H93_RS04750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H93_RS04755	COG4521	taurine ABC transporter
I6H93_RS04770	COG2188	Transcriptional regulator
I6H93_RS04780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6H93_RS04785	COG1733	regulation of RNA biosynthetic process
I6H93_RS04790	COG2207	Transcriptional regulator
I6H93_RS04790	COG3708	Transcriptional regulator
I6H93_RS04805	COG0730	response to heat
I6H93_RS04815	COG3453	Protein conserved in bacteria
I6H93_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H93_RS04825	COG3781	membrane
I6H93_RS04830	COG1063	alcohol dehydrogenase
I6H93_RS04840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H93_RS04845	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H93_RS04850	COG0022	dehydrogenase e1 component
I6H93_RS04855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H93_RS04860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6H93_RS04875	COG3706	GGDEF domain
I6H93_RS04890	COG0133	tryptophan synthase activity
I6H93_RS04900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H93_RS04935	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H93_RS04960	COG2226	methyltransferase
I6H93_RS05015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6H93_RS05020	COG4773	Receptor
I6H93_RS05040	COG0730	response to heat
I6H93_RS05045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H93_RS05060	COG0406	alpha-ribazole phosphatase activity
I6H93_RS05065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6H93_RS05080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H93_RS05110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H93_RS05120	COG4264	IucA IucC family
I6H93_RS05125	COG4264	IucA IucC family
I6H93_RS05130	COG2814	Major facilitator Superfamily
I6H93_RS05145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H93_RS05160	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS05165	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS05170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6H93_RS05175	COG2207	Transcriptional regulator
I6H93_RS05180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H93_RS05185	COG0776	regulation of translation
I6H93_RS05210	COG0822	iron-sulfur transferase activity
I6H93_RS05215	COG0316	Belongs to the HesB IscA family
I6H93_RS05245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H93_RS05265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6H93_RS05270	COG0702	epimerase
I6H93_RS05305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H93_RS05315	COG0339	signal peptide processing
I6H93_RS05335	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6H93_RS05360	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6H93_RS05365	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6H93_RS05395	COG0776	regulation of translation
I6H93_RS05460	COG0084	hydrolase, TatD family'
I6H93_RS05480	COG1663	tetraacyldisaccharide 4'-kinase activity
I6H93_RS05485	COG1132	(ABC) transporter
I6H93_RS05495	COG0811	peptide transport
I6H93_RS05500	COG1475	DNA binding
I6H93_RS05505	COG1192	Involved in chromosome partitioning
I6H93_RS05515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6H93_RS05530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H93_RS05535	COG0191	fructose-bisphosphate aldolase activity
I6H93_RS05555	COG0424	maF-like protein
I6H93_RS05560	COG2850	peptidyl-arginine hydroxylation
I6H93_RS05570	COG0640	Transcriptional regulator
I6H93_RS05580	COG3619	membrane
I6H93_RS05585	COG3122	Protein conserved in bacteria
I6H93_RS05610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6H93_RS05615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H93_RS05625	COG0506	proline dehydrogenase activity
I6H93_RS05625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6H93_RS05625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6H93_RS05630	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6H93_RS05645	COG3698	Phosphodiester glycosidase
I6H93_RS05655	COG2353	YceI-like domain
I6H93_RS05665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6H93_RS05710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6H93_RS05710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H93_RS05735	COG3539	Fimbrial protein
I6H93_RS05740	COG3121	Chaperone
I6H93_RS05765	COG0697	spore germination
I6H93_RS05775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6H93_RS05785	COG0583	DNA-binding transcription factor activity
I6H93_RS05805	COG1309	transcriptional regulator
I6H93_RS05820	COG1522	sequence-specific DNA binding
I6H93_RS05830	COG1126	abc transporter atp-binding protein
I6H93_RS05835	COG0765	amino acid transport
I6H93_RS05840	COG0765	amino acid transport
I6H93_RS05870	COG1464	Belongs to the NlpA lipoprotein family
I6H93_RS05880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H93_RS05885	COG2011	ABC-type metal ion transport system permease component
I6H93_RS05890	COG0012	GTP binding
I6H93_RS05915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H93_RS05955	COG0386	Belongs to the glutathione peroxidase family
I6H93_RS05965	COG0436	Aminotransferase
I6H93_RS05970	COG1301	dicarboxylic acid transport
I6H93_RS06005	COG3634	alkyl hydroperoxide reductase activity
I6H93_RS06020	COG0583	DNA-binding transcription factor activity
I6H93_RS06025	COG0798	PFAM Bile acid sodium symporter
I6H93_RS06030	COG0640	Transcriptional regulator
I6H93_RS06045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6H93_RS06055	COG0583	DNA-binding transcription factor activity
I6H93_RS06065	COG1953	Uracil, thiamine, allantoin
I6H93_RS06075	COG2175	clavaminate synthase activity
I6H93_RS06080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H93_RS06085	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6H93_RS06090	COG4521	taurine ABC transporter
I6H93_RS06100	COG0477	Major facilitator Superfamily
I6H93_RS06120	COG1271	oxidase subunit
I6H93_RS06125	COG1294	oxidase, subunit
I6H93_RS06135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H93_RS06155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H93_RS06175	COG3052	prosthetic group binding
I6H93_RS06180	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6H93_RS06190	COG2814	Major facilitator Superfamily
I6H93_RS06205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H93_RS06210	COG1346	cytolysis
I6H93_RS06220	COG0583	DNA-binding transcription factor activity
I6H93_RS06225	COG0625	glutathione transferase activity
I6H93_RS06230	COG0625	glutathione transferase activity
I6H93_RS06235	COG0583	DNA-binding transcription factor activity
I6H93_RS06250	COG1045	serine acetyltransferase
I6H93_RS06255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H93_RS06260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H93_RS06265	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS06275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H93_RS06280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H93_RS06285	COG1126	abc transporter atp-binding protein
I6H93_RS06290	COG0765	amino acid transport
I6H93_RS06295	COG0765	amino acid transport
I6H93_RS06315	COG0784	Response regulator, receiver
I6H93_RS06315	COG2205	protein histidine kinase activity
I6H93_RS06355	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS06405	COG0583	DNA-binding transcription factor activity
I6H93_RS06425	COG0318	PFAM AMP-dependent synthetase and ligase
I6H93_RS06430	COG1309	transcriptional regulator
I6H93_RS06435	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS06440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H93_RS06445	COG1024	Enoyl-CoA hydratase
I6H93_RS06450	COG4770	biotin carboxylase activity
I6H93_RS06460	COG0583	DNA-binding transcription factor activity
I6H93_RS06475	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS06485	COG2814	Major facilitator Superfamily
I6H93_RS06495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6H93_RS06500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H93_RS06505	COG2814	Major facilitator Superfamily
I6H93_RS06510	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS06515	COG1024	Enoyl-CoA hydratase
I6H93_RS06520	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H93_RS06530	COG0183	Belongs to the thiolase family
I6H93_RS06540	COG2814	Major facilitator Superfamily
I6H93_RS06550	COG1024	Enoyl-CoA hydratase
I6H93_RS06560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H93_RS06565	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS06570	COG2814	Major facilitator Superfamily
I6H93_RS06575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H93_RS06580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6H93_RS06595	COG3842	ATPase activity
I6H93_RS06600	COG1840	ABC-type Fe3 transport system, periplasmic component
I6H93_RS06610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H93_RS06615	COG1414	Transcriptional regulator
I6H93_RS06625	COG0583	DNA-binding transcription factor activity
I6H93_RS06630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6H93_RS06635	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS06645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6H93_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS06660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H93_RS06665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS06670	COG2267	carboxylic ester hydrolase activity
I6H93_RS06690	COG3038	cytochrome b561
I6H93_RS06695	COG0753	catalase activity
I6H93_RS06705	COG2271	Major facilitator Superfamily
I6H93_RS06710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H93_RS06715	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H93_RS06745	COG1278	Cold shock
I6H93_RS06780	COG0210	DNA helicase
I6H93_RS06785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H93_RS06790	COG2050	protein possibly involved in aromatic compounds catabolism
I6H93_RS06800	COG3327	negative regulation of DNA-templated transcription, initiation
I6H93_RS06805	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6H93_RS06810	COG0183	Belongs to the thiolase family
I6H93_RS06815	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H93_RS06820	COG1024	Enoyl-CoA hydratase
I6H93_RS06825	COG1024	Enoyl-CoA hydratase
I6H93_RS06830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H93_RS06835	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H93_RS06840	COG3396	Phenylacetate-CoA oxygenase
I6H93_RS06845	COG3460	Phenylacetate-CoA oxygenase
I6H93_RS06850	COG3396	Phenylacetate-CoA oxygenase
I6H93_RS06855	COG2030	dehydratase
I6H93_RS06855	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS06860	COG1760	l-serine dehydratase
I6H93_RS06865	COG0531	amino acid
I6H93_RS06870	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS06895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H93_RS06915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H93_RS06925	COG0789	Transcriptional regulator
I6H93_RS06935	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H93_RS06950	COG2807	transmembrane transport
I6H93_RS06955	COG0590	tRNA wobble adenosine to inosine editing
I6H93_RS07070	COG1116	anion transmembrane transporter activity
I6H93_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H93_RS07085	COG0864	Transcriptional regulator
I6H93_RS07095	COG1733	regulation of RNA biosynthetic process
I6H93_RS07100	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H93_RS07105	COG0439	Biotin carboxylase
I6H93_RS07120	COG1063	alcohol dehydrogenase
I6H93_RS07130	COG1309	transcriptional regulator
I6H93_RS07155	COG0038	chloride channel
I6H93_RS07160	COG4770	biotin carboxylase activity
I6H93_RS07180	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H93_RS07185	COG0583	DNA-binding transcription factor activity
I6H93_RS07205	COG3209	COG3209 Rhs family protein
I6H93_RS07250	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H93_RS07270	COG2814	Major facilitator Superfamily
I6H93_RS07280	COG1560	Kdo2-lipid A biosynthetic process
I6H93_RS07290	COG5006	permease, DMT superfamily
I6H93_RS07295	COG1522	sequence-specific DNA binding
I6H93_RS07310	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6H93_RS07320	COG4122	O-methyltransferase activity
I6H93_RS07350	COG1538	Outer membrane efflux protein
I6H93_RS07355	COG1137	ATPase activity
I6H93_RS07360	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6H93_RS07370	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6H93_RS07425	COG5434	Belongs to the glycosyl hydrolase 28 family
I6H93_RS07445	COG3566	protein conserved in bacteria
I6H93_RS07465	COG3567	Phage-associated protein, HI1409 family
I6H93_RS07470	COG5410	chromosome segregation
I6H93_RS07540	COG2814	Major facilitator Superfamily
I6H93_RS07575	COG1278	Cold shock
I6H93_RS07580	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS07610	COG1570	exodeoxyribonuclease VII activity
I6H93_RS07660	COG0583	DNA-binding transcription factor activity
I6H93_RS07665	COG4638	Rieske (2fe-2S)
I6H93_RS07670	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6H93_RS07675	COG0633	Ferredoxin
I6H93_RS07675	COG0543	2 iron, 2 sulfur cluster binding
I6H93_RS07680	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS07685	COG3135	benzoate transporter
I6H93_RS07690	COG2814	Major facilitator Superfamily
I6H93_RS07705	COG1643	Atp-dependent helicase
I6H93_RS07710	COG0450	alkyl hydroperoxide reductase
I6H93_RS07720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6H93_RS07730	COG3634	alkyl hydroperoxide reductase activity
I6H93_RS07750	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H93_RS07755	COG0625	glutathione transferase activity
I6H93_RS07765	COG2885	chlorophyll binding
I6H93_RS07800	COG0542	response to heat
I6H93_RS07815	COG1765	OsmC-like protein
I6H93_RS07830	COG0667	Aldo Keto reductase
I6H93_RS07845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H93_RS07855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6H93_RS07865	COG0582	viral genome integration into host DNA
I6H93_RS07890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H93_RS07965	COG0592	DNA-directed DNA polymerase activity
I6H93_RS08175	COG1484	DNA-dependent DNA replication
I6H93_RS08255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H93_RS08295	COG0527	aspartate kinase activity
I6H93_RS08305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H93_RS08315	COG3038	cytochrome b561
I6H93_RS08320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6H93_RS08325	COG2252	PERMEase
I6H93_RS08335	COG2072	flavoprotein involved in K transport
I6H93_RS08350	COG1741	Belongs to the pirin family
I6H93_RS08355	COG1309	transcriptional regulator
I6H93_RS08365	COG0300	oxidoreductase activity
I6H93_RS08370	COG2072	flavoprotein involved in K transport
I6H93_RS08375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6H93_RS08420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H93_RS08435	COG2814	Major facilitator Superfamily
I6H93_RS08440	COG1024	Enoyl-CoA hydratase
I6H93_RS08445	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS08455	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS08480	COG2186	Transcriptional regulator
I6H93_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
I6H93_RS08500	COG2271	Major facilitator Superfamily
I6H93_RS08505	COG2721	sulfolactate sulfo-lyase activity
I6H93_RS08510	COG0697	spore germination
I6H93_RS08540	COG1113	amino acid transport
I6H93_RS08560	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS08580	COG0531	amino acid
I6H93_RS08590	COG1113	amino acid transport
I6H93_RS08620	COG3209	COG3209 Rhs family protein
I6H93_RS08650	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS08650	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H93_RS08660	COG2203	Gaf domain
I6H93_RS08660	COG3706	GGDEF domain
I6H93_RS08660	COG5001	Diguanylate cyclase
I6H93_RS08660	COG4251	negative regulation of phosphorylation
I6H93_RS08670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H93_RS08735	COG4172	Belongs to the ABC transporter superfamily
I6H93_RS08740	COG4239	(ABC) transporter, permease
I6H93_RS08745	COG4174	ABC transporter (Permease)
I6H93_RS08755	COG1388	LysM domain
I6H93_RS08755	COG0741	lytic transglycosylase activity
I6H93_RS08755	COG1388	LysM domain
I6H93_RS08755	COG0741	lytic transglycosylase activity
I6H93_RS08760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H93_RS08800	COG0583	DNA-binding transcription factor activity
I6H93_RS08805	COG1279	arginine transmembrane transporter activity
I6H93_RS08825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H93_RS08830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H93_RS08835	COG0006	proline dipeptidase activity
I6H93_RS08875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H93_RS08895	COG3384	dioxygenase
I6H93_RS08905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H93_RS08910	COG2878	Part of a membrane complex involved in electron transport
I6H93_RS08915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H93_RS08940	COG0768	penicillin binding
I6H93_RS08945	COG0742	ribosomal rna small subunit methyltransferase
I6H93_RS08960	COG0830	nickel cation binding
I6H93_RS09005	COG1253	flavin adenine dinucleotide binding
I6H93_RS09010	COG2851	Citrate transporter
I6H93_RS09060	COG1773	rubredoxin
I6H93_RS09065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H93_RS09075	COG0583	DNA-binding transcription factor activity
I6H93_RS09105	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6H93_RS09110	COG4181	ATPase activity
I6H93_RS09155	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6H93_RS09175	COG0306	phosphate transporter
I6H93_RS09185	COG3958	Transketolase
I6H93_RS09190	COG3959	Transketolase, thiamine diphosphate binding domain
I6H93_RS09195	COG2271	Major facilitator Superfamily
I6H93_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS09205	COG0583	DNA-binding transcription factor activity
I6H93_RS09220	COG2223	nitrite transmembrane transporter activity
I6H93_RS09225	COG2207	Transcriptional regulator
I6H93_RS09230	COG2066	Belongs to the glutaminase family
I6H93_RS09235	COG0242	peptide deformylase activity
I6H93_RS09240	COG0477	Major facilitator Superfamily
I6H93_RS09250	COG0028	Belongs to the TPP enzyme family
I6H93_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS09270	COG2267	carboxylic ester hydrolase activity
I6H93_RS09280	COG2271	Major facilitator Superfamily
I6H93_RS09285	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H93_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS09315	COG1414	Transcriptional regulator
I6H93_RS09330	COG1024	Enoyl-CoA hydratase
I6H93_RS09340	COG1215	transferase activity, transferring glycosyl groups
I6H93_RS09345	COG1649	PFAM Uncharacterised BCR, COG1649
I6H93_RS09345	COG0726	polysaccharide deacetylase
I6H93_RS09355	COG4681	YaeQ
I6H93_RS09365	COG0523	cobalamin synthesis protein
I6H93_RS09375	COG1607	acyl-coa hydrolase
I6H93_RS09385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H93_RS09390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H93_RS09395	COG1309	transcriptional regulator
I6H93_RS09420	COG2040	homocysteine
I6H93_RS09425	COG0531	amino acid
I6H93_RS09480	COG1595	DNA-templated transcription, initiation
I6H93_RS09490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H93_RS09495	COG0477	Major facilitator Superfamily
I6H93_RS09515	COG0084	hydrolase, TatD family'
I6H93_RS09550	COG0629	single-stranded DNA binding
I6H93_RS09605	COG0582	viral genome integration into host DNA
I6H93_RS09615	COG0405	Gamma-glutamyltransferase
I6H93_RS09620	COG2814	Major facilitator Superfamily
I6H93_RS09630	COG2050	protein possibly involved in aromatic compounds catabolism
I6H93_RS09645	COG1090	epimerase
I6H93_RS09665	COG0420	3'-5' exonuclease activity
I6H93_RS09690	COG0735	belongs to the Fur family
I6H93_RS09695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6H93_RS09715	COG0121	glutamine amidotransferase
I6H93_RS09730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H93_RS09740	COG0210	DNA helicase
I6H93_RS09745	COG2885	chlorophyll binding
I6H93_RS09750	COG0204	Acyl-transferase
I6H93_RS09765	COG2894	cell division
I6H93_RS09780	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS09785	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6H93_RS09785	COG1674	ftsk spoiiie
I6H93_RS09790	COG0492	ferredoxin-NADP+ reductase activity
I6H93_RS09795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6H93_RS09805	COG0456	acetyltransferase
I6H93_RS09855	COG1981	membrane
I6H93_RS09870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H93_RS09870	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6H93_RS09890	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS09900	COG0657	acetylesterase activity
I6H93_RS09910	COG0473	3-isopropylmalate dehydrogenase activity
I6H93_RS09915	COG0583	DNA-binding transcription factor activity
I6H93_RS09935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H93_RS09960	COG0564	pseudouridine synthase activity
I6H93_RS09970	COG0358	DNA primase activity
I6H93_RS09985	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6H93_RS10015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6H93_RS10045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H93_RS10055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H93_RS10055	COG0352	thiamine-phosphate diphosphorylase activity
I6H93_RS10055	COG0351	phosphomethylpyrimidine kinase
I6H93_RS10060	COG1652	LysM domain
I6H93_RS10085	COG1399	metal-binding, possibly nucleic acid-binding protein
I6H93_RS10090	COG3101	peptidyl-lysine hydroxylation
I6H93_RS10095	COG0009	L-threonylcarbamoyladenylate synthase
I6H93_RS10100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6H93_RS10105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6H93_RS10120	COG4106	trans-aconitate 2-methyltransferase activity
I6H93_RS10135	COG2226	methyltransferase
I6H93_RS10135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H93_RS10135	COG0596	Alpha beta hydrolase
I6H93_RS10140	COG1877	trehalose-phosphatase activity
I6H93_RS10145	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6H93_RS10150	COG2223	nitrite transmembrane transporter activity
I6H93_RS10170	COG1196	nuclear chromosome segregation
I6H93_RS10180	COG0730	response to heat
I6H93_RS10195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H93_RS10205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H93_RS10255	COG0489	protein tyrosine kinase activity
I6H93_RS10265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H93_RS10265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H93_RS10295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6H93_RS10300	COG2081	HI0933 family
I6H93_RS10310	COG0668	transmembrane transport
I6H93_RS10330	COG0583	DNA-binding transcription factor activity
I6H93_RS10355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6H93_RS10360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H93_RS10390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6H93_RS10430	COG0745	RESPONSE REGULATOR receiver
I6H93_RS10450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H93_RS10460	COG0384	phenazine biosynthesis protein PhzF
I6H93_RS10490	COG1309	transcriptional regulator
I6H93_RS10495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS10510	COG0583	DNA-binding transcription factor activity
I6H93_RS10540	COG0583	DNA-binding transcription factor activity
I6H93_RS10555	COG0583	DNA-binding transcription factor activity
I6H93_RS10560	COG1053	succinate dehydrogenase
I6H93_RS10570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6H93_RS10575	COG2814	Major facilitator Superfamily
I6H93_RS10580	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS10585	COG0583	DNA-binding transcription factor activity
I6H93_RS10590	COG1063	alcohol dehydrogenase
I6H93_RS10620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H93_RS10625	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H93_RS10630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H93_RS10645	COG3667	copper resistance
I6H93_RS10650	COG2132	Multicopper oxidase
I6H93_RS10660	COG0561	phosphatase activity
I6H93_RS10665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H93_RS10675	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6H93_RS10690	COG1214	PFAM Peptidase M22, glycoprotease
I6H93_RS10740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H93_RS10750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H93_RS10755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6H93_RS10760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H93_RS10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H93_RS10830	COG1846	Transcriptional regulator
I6H93_RS10835	COG1764	response to oxidative stress
I6H93_RS10875	COG0037	tRNA processing
I6H93_RS10885	COG0248	Ppx GppA phosphatase
I6H93_RS10915	COG0072	phenylalanine-tRNA ligase activity
I6H93_RS10950	COG1238	metal cluster binding
I6H93_RS10955	COG0625	glutathione transferase activity
I6H93_RS10970	COG0318	PFAM AMP-dependent synthetase and ligase
I6H93_RS10975	COG3028	Belongs to the UPF0307 family
I6H93_RS10980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H93_RS11000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H93_RS11005	COG0617	tRNA 3'-terminal CCA addition
I6H93_RS11010	COG1555	photosystem II stabilization
I6H93_RS11015	COG3956	TIGRFAM MazG family protein
I6H93_RS11025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H93_RS11045	COG5002	protein histidine kinase activity
I6H93_RS11045	COG2205	protein histidine kinase activity
I6H93_RS11045	COG0784	Response regulator, receiver
I6H93_RS11050	COG1024	Enoyl-CoA hydratase
I6H93_RS11055	COG2084	Dehydrogenase
I6H93_RS11060	COG3622	Belongs to the hyi family
I6H93_RS11090	COG0697	spore germination
I6H93_RS11100	COG2814	Major facilitator Superfamily
I6H93_RS11120	COG2132	Multicopper oxidase
I6H93_RS11135	COG2205	protein histidine kinase activity
I6H93_RS11225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H93_RS11235	COG0583	DNA-binding transcription factor activity
I6H93_RS11245	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H93_RS11255	COG0084	hydrolase, TatD family'
I6H93_RS11270	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6H93_RS11300	COG0440	acetolactate synthase activity
I6H93_RS11305	COG0028	Belongs to the TPP enzyme family
I6H93_RS11330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS11335	COG0577	efflux transmembrane transporter activity
I6H93_RS11335	COG1136	(ABC) transporter
I6H93_RS11340	COG1538	Outer membrane efflux protein
I6H93_RS11355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6H93_RS11360	COG1162	GTPase activity
I6H93_RS11370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H93_RS11410	COG1426	Protein conserved in bacteria
I6H93_RS11445	COG0793	Belongs to the peptidase S41A family
I6H93_RS11460	COG2267	carboxylic ester hydrolase activity
I6H93_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS11475	COG3265	gluconokinase activity
I6H93_RS11485	COG0800	Aldolase
I6H93_RS11495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6H93_RS11500	COG0857	belongs to the CobB CobQ family
I6H93_RS11500	COG0280	phosphate acetyltransferase
I6H93_RS11505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6H93_RS11505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6H93_RS11525	COG0740	serine-type endopeptidase activity
I6H93_RS11535	COG4774	siderophore transport
I6H93_RS11545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6H93_RS11555	COG2813	Specifically methylates the guanine in position
I6H93_RS11555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6H93_RS11630	COG0589	response to stress
I6H93_RS11635	COG0659	secondary active sulfate transmembrane transporter activity
I6H93_RS11735	COG0788	formyltetrahydrofolate deformylase activity
I6H93_RS11760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H93_RS11760	COG4651	solute:proton antiporter activity
I6H93_RS11780	COG0724	RNA recognition motif
I6H93_RS11785	COG0210	DNA helicase
I6H93_RS11810	COG1733	regulation of RNA biosynthetic process
I6H93_RS11820	COG2900	Belongs to the SlyX family
I6H93_RS11840	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS11845	COG1560	Kdo2-lipid A biosynthetic process
I6H93_RS11855	COG1301	dicarboxylic acid transport
I6H93_RS11910	COG0473	3-isopropylmalate dehydrogenase activity
I6H93_RS11965	COG0583	DNA-binding transcription factor activity
I6H93_RS11975	COG0625	glutathione transferase activity
I6H93_RS11980	COG2378	regulation of single-species biofilm formation
I6H93_RS11985	COG0546	phosphoglycolate phosphatase activity
I6H93_RS12000	COG1530	ribonuclease E activity
I6H93_RS12005	COG0318	PFAM AMP-dependent synthetase and ligase
I6H93_RS12020	COG0583	DNA-binding transcription factor activity
I6H93_RS12025	COG4221	oxidoreductase activity
I6H93_RS12030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H93_RS12040	COG0534	Mate efflux family protein
I6H93_RS12055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6H93_RS12080	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6H93_RS12080	COG0493	'glutamate synthase
I6H93_RS12090	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6H93_RS12095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H93_RS12110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H93_RS12120	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6H93_RS12120	COG0644	oxidoreductase
I6H93_RS12130	COG0425	Belongs to the sulfur carrier protein TusA family
I6H93_RS12135	COG4535	Mg2 and Co2 transporter CorC
I6H93_RS12145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H93_RS12165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H93_RS12170	COG0475	glutathione-regulated potassium exporter activity
I6H93_RS12170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H93_RS12185	COG0484	heat shock protein binding
I6H93_RS12190	COG0789	Transcriptional regulator
I6H93_RS12195	COG0598	Magnesium transport protein CorA
I6H93_RS12210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H93_RS12215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H93_RS12220	COG1074	ATP-dependent DNA helicase activity
I6H93_RS12225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6H93_RS12245	COG2226	methyltransferase
I6H93_RS12260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H93_RS12265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6H93_RS12280	COG2111	Na H antiporter
I6H93_RS12280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6H93_RS12285	COG1006	Multisubunit Na H antiporter MnhC subunit
I6H93_RS12290	COG0651	ATP synthesis coupled electron transport
I6H93_RS12295	COG1863	multisubunit Na H antiporter MnhE subunit
I6H93_RS12300	COG2212	antiporter activity
I6H93_RS12305	COG1320	monovalent cation:proton antiporter activity
I6H93_RS12320	COG0195	Participates in both transcription termination and antitermination
I6H93_RS12370	COG0237	dephospho-CoA kinase activity
I6H93_RS12380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H93_RS12395	COG0497	DNA recombination
I6H93_RS12405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6H93_RS12435	COG2169	Transcriptional regulator
I6H93_RS12435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6H93_RS12440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H93_RS12500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6H93_RS12515	COG0326	Molecular chaperone. Has ATPase activity
I6H93_RS12530	COG2056	Na+-H+ antiporter family
I6H93_RS12630	COG0546	phosphoglycolate phosphatase activity
I6H93_RS12635	COG1716	ATPase activity
I6H93_RS12680	COG0181	hydroxymethylbilane synthase activity
I6H93_RS12690	COG3275	phosphorelay sensor kinase activity
I6H93_RS12710	COG1538	Outer membrane efflux protein
I6H93_RS12715	COG0697	spore germination
I6H93_RS12740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H93_RS12745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6H93_RS12750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H93_RS12755	COG0772	Belongs to the SEDS family
I6H93_RS12780	COG4974	Belongs to the 'phage' integrase family
I6H93_RS12785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H93_RS12795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H93_RS12805	COG2197	response regulator
I6H93_RS12820	COG0793	Belongs to the peptidase S41A family
I6H93_RS12825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6H93_RS12830	COG0795	lipopolysaccharide-transporting ATPase activity
I6H93_RS12870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H93_RS12870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H93_RS12880	COG0004	ammonium transporteR
I6H93_RS12885	COG0347	Belongs to the P(II) protein family
I6H93_RS12895	COG0606	chelatase, subunit chli
I6H93_RS12905	COG0659	secondary active sulfate transmembrane transporter activity
I6H93_RS12930	COG0789	Transcriptional regulator
I6H93_RS12950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H93_RS13030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H93_RS13085	COG0697	spore germination
I6H93_RS13105	COG0789	Transcriptional regulator
I6H93_RS13180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H93_RS13205	COG0789	Transcriptional regulator
I6H93_RS13210	COG0589	response to stress
I6H93_RS13220	COG0640	Transcriptional regulator
I6H93_RS13230	COG0798	PFAM Bile acid sodium symporter
I6H93_RS13235	COG0431	NADPH-dependent FMN reductase
I6H93_RS13240	COG0492	ferredoxin-NADP+ reductase activity
I6H93_RS13245	COG2072	flavoprotein involved in K transport
I6H93_RS13275	COG0606	chelatase, subunit chli
I6H93_RS13280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H93_RS13290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H93_RS13305	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6H93_RS13320	COG0318	PFAM AMP-dependent synthetase and ligase
I6H93_RS13330	COG0477	Major facilitator Superfamily
I6H93_RS13335	COG2860	membrane
I6H93_RS13340	COG3012	SEC-C Motif Domain Protein
I6H93_RS13345	COG1253	flavin adenine dinucleotide binding
I6H93_RS13355	COG2814	Major facilitator Superfamily
I6H93_RS13365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H93_RS13400	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6H93_RS13410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6H93_RS13480	COG0758	DNA mediated transformation
I6H93_RS13490	COG0697	spore germination
I6H93_RS13495	COG1309	transcriptional regulator
I6H93_RS13510	COG0386	Belongs to the glutathione peroxidase family
I6H93_RS13575	COG1121	(ABC) transporter
I6H93_RS13580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H93_RS13585	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS13590	COG2837	iron assimilation
I6H93_RS13595	COG0281	malic enzyme
I6H93_RS13640	COG0519	Catalyzes the synthesis of GMP from XMP
I6H93_RS13640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H93_RS13645	COG4399	Belongs to the UPF0754 family
I6H93_RS13650	COG2259	Doxx family
I6H93_RS13655	COG0586	Pfam SNARE associated Golgi protein
I6H93_RS13670	COG1192	Involved in chromosome partitioning
I6H93_RS13680	COG0271	Belongs to the BolA IbaG family
I6H93_RS13700	COG2267	carboxylic ester hydrolase activity
I6H93_RS13720	COG3321	synthase
I6H93_RS13720	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6H93_RS13720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6H93_RS13720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H93_RS13725	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS13735	COG2197	response regulator
I6H93_RS13745	COG3916	Acyl-homoserine-lactone synthase
I6H93_RS13755	COG1024	Enoyl-CoA hydratase
I6H93_RS13760	COG1024	Enoyl-CoA hydratase
I6H93_RS13765	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS13770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H93_RS13790	COG1113	amino acid transport
I6H93_RS13795	COG1113	amino acid transport
I6H93_RS13800	COG0251	oxidation-reduction process
I6H93_RS13840	COG0564	pseudouridine synthase activity
I6H93_RS13855	COG3328	transposase activity
I6H93_RS13885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H93_RS13900	COG1802	Transcriptional regulator
I6H93_RS13910	COG1448	Aminotransferase
I6H93_RS13915	COG0277	FAD linked oxidase domain protein
I6H93_RS13925	COG2186	Transcriptional regulator
I6H93_RS13935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H93_RS13940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H93_RS13955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H93_RS13970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6H93_RS13980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H93_RS14025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6H93_RS14055	COG0728	peptidoglycan biosynthetic process
I6H93_RS14060	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6H93_RS14115	COG0546	phosphoglycolate phosphatase activity
I6H93_RS14120	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS14140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H93_RS14145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6H93_RS14150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H93_RS14155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6H93_RS14160	COG1116	anion transmembrane transporter activity
I6H93_RS14165	COG1309	transcriptional regulator
I6H93_RS14170	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H93_RS14180	COG0196	riboflavin kinase activity
I6H93_RS14185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6H93_RS14195	COG1047	Peptidyl-prolyl cis-trans
I6H93_RS14235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H93_RS14240	COG0657	acetylesterase activity
I6H93_RS14290	COG2951	lytic endotransglycosylase activity
I6H93_RS14295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6H93_RS14310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6H93_RS14320	COG0671	phosphoesterase, PA-phosphatase related
I6H93_RS14325	COG0861	Integral membrane protein TerC family
I6H93_RS14335	COG0754	glutathionylspermidine amidase activity
I6H93_RS14345	COG0402	S-adenosylhomocysteine deaminase activity
I6H93_RS14360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H93_RS14365	COG1230	cation diffusion facilitator family transporter
I6H93_RS14380	COG0706	membrane insertase activity
I6H93_RS14405	COG0592	DNA-directed DNA polymerase activity
I6H93_RS14415	COG0187	DNA topoisomerase II activity
I6H93_RS14425	COG0586	Pfam SNARE associated Golgi protein
I6H93_RS14430	COG0488	(ABC) transporter
I6H93_RS14475	COG0596	Alpha beta hydrolase
I6H93_RS14480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6H93_RS14485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6H93_RS14525	COG0733	neurotransmitter:sodium symporter activity
I6H93_RS14535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H93_RS14560	COG0583	DNA-binding transcription factor activity
I6H93_RS14565	COG2233	PERMEase
I6H93_RS14580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS14615	COG2814	Major facilitator Superfamily
I6H93_RS14620	COG0656	L-ascorbic acid biosynthetic process
I6H93_RS14625	COG0583	DNA-binding transcription factor activity
I6H93_RS14640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H93_RS14645	COG1064	alcohol dehydrogenase
I6H93_RS14650	COG2818	Glycosylase
I6H93_RS14665	COG1194	a g-specific adenine glycosylase
I6H93_RS14685	COG2983	Belongs to the UPF0260 family
I6H93_RS14690	COG2133	pyrroloquinoline quinone binding
I6H93_RS14695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H93_RS14700	COG2116	formate transmembrane transporter activity
I6H93_RS14720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H93_RS14725	COG1335	isochorismatase
I6H93_RS14730	COG0385	Bile acid
I6H93_RS14735	COG0534	Mate efflux family protein
I6H93_RS14740	COG1683	Conserved Protein
I6H93_RS14760	COG0625	glutathione transferase activity
I6H93_RS14770	COG1113	amino acid transport
I6H93_RS14780	COG0523	cobalamin synthesis protein
I6H93_RS14790	COG2188	Transcriptional regulator
I6H93_RS14820	COG0010	Belongs to the arginase family
I6H93_RS14835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H93_RS14865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H93_RS14875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H93_RS14880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6H93_RS14965	COG0534	Mate efflux family protein
I6H93_RS14970	COG0436	Aminotransferase
I6H93_RS14975	COG2733	membrane
I6H93_RS14990	COG2918	glutathione biosynthetic process
I6H93_RS15005	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6H93_RS15005	COG1388	LysM domain
I6H93_RS15005	COG3409	Peptidoglycan-binding domain 1 protein
I6H93_RS15035	COG3150	esterase
I6H93_RS15045	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6H93_RS15055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6H93_RS15065	COG2233	PERMEase
I6H93_RS15070	COG2351	hydroxyisourate hydrolase activity
I6H93_RS15105	COG3706	GGDEF domain
I6H93_RS15120	COG1393	Belongs to the ArsC family
I6H93_RS15125	COG0708	Exodeoxyribonuclease III
I6H93_RS15145	COG0189	ligase activity
I6H93_RS15165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6H93_RS15175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6H93_RS15190	COG4942	peptidase
I6H93_RS15200	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H93_RS15210	COG2119	membrane
I6H93_RS15215	COG4774	siderophore transport
I6H93_RS15220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6H93_RS15220	COG0426	domain, Protein
I6H93_RS15245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H93_RS15265	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS15270	COG1519	Transferase
I6H93_RS15275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H93_RS15280	COG0668	transmembrane transport
I6H93_RS15290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6H93_RS15295	COG1335	isochorismatase
I6H93_RS15300	COG1522	sequence-specific DNA binding
I6H93_RS15325	COG2198	Histidine kinase
I6H93_RS15325	COG0784	Response regulator, receiver
I6H93_RS15325	COG2205	protein histidine kinase activity
I6H93_RS15330	COG3162	membrane
I6H93_RS15335	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6H93_RS15345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6H93_RS15360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6H93_RS15365	COG1309	transcriptional regulator
I6H93_RS15385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H93_RS15385	COG0352	thiamine-phosphate diphosphorylase activity
I6H93_RS15385	COG0351	phosphomethylpyrimidine kinase
I6H93_RS15395	COG2814	Major facilitator Superfamily
I6H93_RS15410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6H93_RS15420	COG1113	amino acid transport
I6H93_RS15430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6H93_RS15435	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS15445	COG1335	isochorismatase
I6H93_RS15475	COG2814	Major facilitator Superfamily
I6H93_RS15480	COG0583	DNA-binding transcription factor activity
I6H93_RS15500	COG0667	Aldo Keto reductase
I6H93_RS15520	COG1733	regulation of RNA biosynthetic process
I6H93_RS15535	COG1733	regulation of RNA biosynthetic process
I6H93_RS15540	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H93_RS15550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H93_RS15610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6H93_RS15650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H93_RS15680	COG0427	acetyl-CoA hydrolase
I6H93_RS15705	COG0659	secondary active sulfate transmembrane transporter activity
I6H93_RS15710	COG4221	oxidoreductase activity
I6H93_RS15715	COG2873	o-acetylhomoserine
I6H93_RS15720	COG0488	(ABC) transporter
I6H93_RS15785	COG0833	amino acid
I6H93_RS15830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6H93_RS15835	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H93_RS15850	COG2226	methyltransferase
I6H93_RS15900	COG0069	glutamate synthase activity
I6H93_RS15900	COG0067	glutamate synthase
I6H93_RS15900	COG0070	glutamate synthase
I6H93_RS15905	COG0493	'glutamate synthase
I6H93_RS15915	COG1704	LemA family
I6H93_RS15920	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6H93_RS15935	COG3307	-O-antigen
I6H93_RS15955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H93_RS15970	COG0194	GDP metabolic process
I6H93_RS16020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H93_RS16040	COG5380	lipid catabolic process
I6H93_RS16045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H93_RS16070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6H93_RS16075	COG0277	FAD linked oxidase domain protein
I6H93_RS16085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6H93_RS16090	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H93_RS16105	COG1289	transmembrane transporter activity
I6H93_RS16115	COG0628	permease
I6H93_RS16120	COG1192	Involved in chromosome partitioning
I6H93_RS16150	COG0833	amino acid
I6H93_RS16155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H93_RS16160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H93_RS16170	COG1012	belongs to the aldehyde dehydrogenase family
I6H93_RS16210	COG0583	DNA-binding transcription factor activity
I6H93_RS16260	COG0517	IMP dehydrogenase activity
I6H93_RS16265	COG1983	PspC domain protein
I6H93_RS16275	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS16290	COG0408	coproporphyrinogen oxidase activity
I6H93_RS16310	COG0513	Belongs to the DEAD box helicase family
I6H93_RS16320	COG1127	ABC transporter
I6H93_RS16325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6H93_RS16335	COG2854	intermembrane phospholipid transfer
I6H93_RS16345	COG0598	Magnesium transport protein CorA
I6H93_RS16355	COG0494	nUDIX hydrolase
I6H93_RS16360	COG1040	competence protein
I6H93_RS16365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H93_RS16385	COG1946	Acyl-CoA thioesterase
I6H93_RS16390	COG1301	dicarboxylic acid transport
I6H93_RS16405	COG1959	2 iron, 2 sulfur cluster binding
I6H93_RS16410	COG1017	nitric oxide dioxygenase activity
I6H93_RS16410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6H93_RS16415	COG0433	COG0433 Predicted ATPase
I6H93_RS16420	COG0626	cystathionine gamma-synthase activity
I6H93_RS16575	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS16580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6H93_RS16610	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6H93_RS16615	COG0339	signal peptide processing
I6H93_RS16620	COG0557	exoribonuclease II activity
I6H93_RS16665	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6H93_RS16670	COG2169	Transcriptional regulator
I6H93_RS16675	COG0697	spore germination
I6H93_RS16680	COG1295	ribonuclease BN
I6H93_RS16715	COG1702	phosphate starvation-inducible protein PhoH
I6H93_RS16725	COG0741	lytic transglycosylase activity
I6H93_RS16725	COG0739	heme binding
I6H93_RS16725	COG1196	nuclear chromosome segregation
I6H93_RS16755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6H93_RS16760	COG1183	phosphatidylcholine synthase activity
I6H93_RS16805	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS16810	COG1309	transcriptional regulator
I6H93_RS16825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6H93_RS16830	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS16850	COG2969	positive regulation of protein catabolic process
I6H93_RS16860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6H93_RS16875	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6H93_RS16880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6H93_RS16900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H93_RS16910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H93_RS16915	COG1408	metallophosphoesterase
I6H93_RS16925	COG2199	diguanylate cyclase activity
I6H93_RS16985	COG1607	acyl-coa hydrolase
I6H93_RS17015	COG2350	Protein conserved in bacteria
I6H93_RS17025	COG0613	PHP domain protein
I6H93_RS17030	COG3781	membrane
I6H93_RS17040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H93_RS17055	COG1862	Preprotein translocase
I6H93_RS17085	COG2205	protein histidine kinase activity
I6H93_RS17090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6H93_RS17110	COG0726	polysaccharide deacetylase
I6H93_RS17115	COG0463	Glycosyl transferase, family 2
I6H93_RS17120	COG0438	transferase activity, transferring glycosyl groups
I6H93_RS17185	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS17190	COG1960	acyl-CoA dehydrogenase activity
I6H93_RS17200	COG2205	protein histidine kinase activity
I6H93_RS17205	COG0745	RESPONSE REGULATOR receiver
I6H93_RS17210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6H93_RS17230	COG2096	Adenosyltransferase
I6H93_RS17280	COG0285	dihydrofolate synthase activity
I6H93_RS17300	COG0450	alkyl hydroperoxide reductase
I6H93_RS17315	COG0477	Major facilitator Superfamily
I6H93_RS17320	COG1272	protein, Hemolysin III
I6H93_RS17330	COG2153	protein acetylation
I6H93_RS17350	COG0183	Belongs to the thiolase family
I6H93_RS17355	COG2207	Transcriptional regulator
I6H93_RS17375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6H93_RS17395	COG0183	Belongs to the thiolase family
I6H93_RS17405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6H93_RS17405	COG2885	chlorophyll binding
I6H93_RS17415	COG1690	Belongs to the RtcB family
I6H93_RS17420	COG0833	amino acid
I6H93_RS17430	COG2233	PERMEase
I6H93_RS17435	COG1217	gtp-binding protein TYPA
I6H93_RS17460	COG2094	Belongs to the DNA glycosylase MPG family
I6H93_RS17465	COG4772	TonB-dependent receptor
I6H93_RS17470	COG1902	pentaerythritol trinitrate reductase activity
I6H93_RS17475	COG0679	Auxin Efflux Carrier
I6H93_RS17485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6H93_RS17490	COG0354	folic acid binding
I6H93_RS17500	COG3189	MarR family transcriptional regulator
I6H93_RS17505	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H93_RS17510	COG3422	double-strand break repair
I6H93_RS17550	COG0840	transmembrane signaling receptor activity
I6H93_RS17565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H93_RS17580	COG5510	response to toxic substance
I6H93_RS17590	COG2832	Protein of unknown function (DUF454)
I6H93_RS17595	COG1376	ErfK ybiS ycfS ynhG family protein
I6H93_RS17635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6H93_RS17645	COG1289	transmembrane transporter activity
I6H93_RS17650	COG2814	Major facilitator Superfamily
I6H93_RS17670	COG1115	amino acid carrier protein
I6H93_RS17675	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6H93_RS17680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H93_RS17685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6H93_RS17710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H93_RS17720	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H93_RS17725	COG1077	Cell shape determining protein MreB Mrl
I6H93_RS17730	COG1792	Involved in formation and maintenance of cell shape
I6H93_RS17735	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6H93_RS17740	COG0424	maF-like protein
I6H93_RS17745	COG1530	ribonuclease E activity
I6H93_RS17755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H93_RS17765	COG0560	Phosphoserine phosphatase
I6H93_RS17775	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6H93_RS17800	COG2207	Transcriptional regulator
I6H93_RS18205	COG0582	viral genome integration into host DNA
I6H93_RS18215	COG1113	amino acid transport
I6H93_RS18220	COG2828	Protein conserved in bacteria
I6H93_RS18225	COG0142	geranyltranstransferase activity
I6H93_RS18230	COG2315	Protein conserved in bacteria
I6H93_RS18245	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6H93_RS18265	COG2194	sulfuric ester hydrolase activity
I6H93_RS18270	COG0745	RESPONSE REGULATOR receiver
I6H93_RS18275	COG0642	Histidine kinase
I6H93_RS18285	COG0004	ammonium transporteR
I6H93_RS18290	COG0583	DNA-binding transcription factor activity
I6H93_RS18310	COG0525	valine-tRNA ligase activity
I6H93_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
I6H93_RS18330	COG0393	Putative heavy-metal-binding
I6H93_RS18335	COG0393	Putative heavy-metal-binding
I6H93_RS18340	COG1538	Outer membrane efflux protein
I6H93_RS18350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS18355	COG0671	phosphoesterase, PA-phosphatase related
I6H93_RS18385	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6H93_RS18400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6H93_RS18400	COG1648	precorrin-2 dehydrogenase activity
I6H93_RS18405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6H93_RS18410	COG1733	regulation of RNA biosynthetic process
I6H93_RS18420	COG0531	amino acid
I6H93_RS18435	COG0321	lipoyl(octanoyl) transferase activity
I6H93_RS18440	COG2921	Belongs to the UPF0250 family
I6H93_RS18475	COG2009	succinate dehydrogenase
I6H93_RS18480	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6H93_RS18485	COG1053	succinate dehydrogenase
I6H93_RS18490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6H93_RS18515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H93_RS18545	COG2354	Protein conserved in bacteria
I6H93_RS18550	COG2321	neutral zinc metallopeptidase
I6H93_RS18620	COG2843	Capsule synthesis protein
I6H93_RS18635	COG0589	response to stress
I6H93_RS18655	COG0505	Belongs to the CarA family
I6H93_RS18680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H93_RS18685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6H93_RS18735	COG0477	Major facilitator Superfamily
I6H93_RS18740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6H93_RS18755	COG1597	lipid kinase activity
I6H93_RS18760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6H93_RS18785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6H93_RS18790	COG0584	glycerophosphoryl diester phosphodiesterase
I6H93_RS18810	COG0741	lytic transglycosylase activity
I6H93_RS18830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6H93_RS18845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6H93_RS18875	COG0778	Nitroreductase
I6H93_RS18890	COG1929	Belongs to the glycerate kinase type-1 family
I6H93_RS18895	COG0243	molybdopterin cofactor binding
I6H93_RS18900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6H93_RS18905	COG3339	Conserved Protein
I6H93_RS18915	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6H93_RS18930	COG1113	amino acid transport
I6H93_RS18940	COG0019	diaminopimelate decarboxylase activity
I6H93_RS18950	COG2267	carboxylic ester hydrolase activity
I6H93_RS18955	COG1280	lysine exporter protein (LysE YggA)
I6H93_RS18960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6H93_RS18990	COG0463	Glycosyl transferase, family 2
I6H93_RS19010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H93_RS19045	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H93_RS19050	COG1136	(ABC) transporter
I6H93_RS19055	COG0658	competence protein
I6H93_RS19055	COG2333	competence protein COMEC
I6H93_RS19065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6H93_RS19065	COG0616	signal peptide processing
I6H93_RS19070	COG0596	Alpha beta hydrolase
I6H93_RS19075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H93_RS19085	COG0628	permease
I6H93_RS19120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H93_RS19140	COG0823	Involved in the tonB-independent uptake of proteins
I6H93_RS19160	COG0824	Thioesterase
I6H93_RS19165	COG1473	amidohydrolase
I6H93_RS19185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H93_RS19185	COG0047	phosphoribosylformylglycinamidine synthase activity
I6H93_RS19190	COG2814	Major facilitator Superfamily
I6H93_RS19200	COG1024	Enoyl-CoA hydratase
I6H93_RS19205	COG1051	belongs to the nudix hydrolase family
I6H93_RS19205	COG1056	cytidyltransferase-related domain
I6H93_RS19215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6H93_RS19230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H93_RS19245	COG4625	pathogenesis
I6H93_RS19250	COG0583	DNA-binding transcription factor activity
I6H93_RS19255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6H93_RS19260	COG4208	sulfate ABC transporter
I6H93_RS19265	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6H93_RS19275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6H93_RS19280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H93_RS19285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H93_RS19305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H93_RS19320	COG0681	Belongs to the peptidase S26 family
I6H93_RS19335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6H93_RS19345	COG1381	Involved in DNA repair and RecF pathway recombination
I6H93_RS19350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6H93_RS19360	COG4221	oxidoreductase activity
I6H93_RS19390	COG0436	Aminotransferase
I6H93_RS19410	COG0556	nucleotide-excision repair