locus-tag	class	description
I6K89_RS00045	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS00065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K89_RS00085	COG0784	Response regulator, receiver
I6K89_RS00085	COG2205	protein histidine kinase activity
I6K89_RS00105	COG0765	amino acid transport
I6K89_RS00110	COG0765	amino acid transport
I6K89_RS00115	COG1126	abc transporter atp-binding protein
I6K89_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K89_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K89_RS00140	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS00150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K89_RS00155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K89_RS00160	COG1045	serine acetyltransferase
I6K89_RS00175	COG0583	DNA-binding transcription factor activity
I6K89_RS00180	COG0625	glutathione transferase activity
I6K89_RS00185	COG0625	glutathione transferase activity
I6K89_RS00190	COG0583	DNA-binding transcription factor activity
I6K89_RS00200	COG1346	cytolysis
I6K89_RS00220	COG2814	Major facilitator Superfamily
I6K89_RS00230	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6K89_RS00235	COG3052	prosthetic group binding
I6K89_RS00255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K89_RS00275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K89_RS00285	COG1294	oxidase, subunit
I6K89_RS00290	COG1271	oxidase subunit
I6K89_RS00310	COG0477	Major facilitator Superfamily
I6K89_RS00320	COG4521	taurine ABC transporter
I6K89_RS00325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K89_RS00330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K89_RS00335	COG2175	clavaminate synthase activity
I6K89_RS00345	COG1953	Uracil, thiamine, allantoin
I6K89_RS00355	COG0583	DNA-binding transcription factor activity
I6K89_RS00365	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6K89_RS00380	COG0640	Transcriptional regulator
I6K89_RS00385	COG0798	PFAM Bile acid sodium symporter
I6K89_RS00390	COG0583	DNA-binding transcription factor activity
I6K89_RS00405	COG3634	alkyl hydroperoxide reductase activity
I6K89_RS00445	COG0436	Aminotransferase
I6K89_RS00455	COG0386	Belongs to the glutathione peroxidase family
I6K89_RS00495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K89_RS00520	COG0012	GTP binding
I6K89_RS00525	COG2011	ABC-type metal ion transport system permease component
I6K89_RS00530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K89_RS00540	COG1464	Belongs to the NlpA lipoprotein family
I6K89_RS00570	COG0765	amino acid transport
I6K89_RS00575	COG0765	amino acid transport
I6K89_RS00580	COG1126	abc transporter atp-binding protein
I6K89_RS00590	COG1522	sequence-specific DNA binding
I6K89_RS00605	COG1309	transcriptional regulator
I6K89_RS00625	COG0583	DNA-binding transcription factor activity
I6K89_RS00635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K89_RS00645	COG0697	spore germination
I6K89_RS00670	COG3121	Chaperone
I6K89_RS00675	COG3539	Fimbrial protein
I6K89_RS00700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K89_RS00700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K89_RS00745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K89_RS00755	COG2353	YceI-like domain
I6K89_RS00765	COG3698	Phosphodiester glycosidase
I6K89_RS00780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K89_RS00785	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K89_RS00785	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K89_RS00785	COG0506	proline dehydrogenase activity
I6K89_RS00795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K89_RS00800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K89_RS00820	COG1132	(ABC) transporter
I6K89_RS00825	COG3122	Protein conserved in bacteria
I6K89_RS00830	COG3619	membrane
I6K89_RS00840	COG0640	Transcriptional regulator
I6K89_RS00850	COG2850	peptidyl-arginine hydroxylation
I6K89_RS00855	COG0424	maF-like protein
I6K89_RS00875	COG0191	fructose-bisphosphate aldolase activity
I6K89_RS00880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K89_RS00895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6K89_RS00905	COG1192	Involved in chromosome partitioning
I6K89_RS00910	COG1475	DNA binding
I6K89_RS00915	COG0811	peptide transport
I6K89_RS00925	COG1132	(ABC) transporter
I6K89_RS00930	COG1663	tetraacyldisaccharide 4'-kinase activity
I6K89_RS00950	COG0084	hydrolase, TatD family'
I6K89_RS01015	COG0776	regulation of translation
I6K89_RS01045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K89_RS01050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K89_RS01100	COG0339	signal peptide processing
I6K89_RS01110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K89_RS01145	COG0702	epimerase
I6K89_RS01150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K89_RS01170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K89_RS01200	COG0316	Belongs to the HesB IscA family
I6K89_RS01205	COG0822	iron-sulfur transferase activity
I6K89_RS01230	COG0776	regulation of translation
I6K89_RS01235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K89_RS01240	COG2207	Transcriptional regulator
I6K89_RS01245	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K89_RS01250	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS01255	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS01270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K89_RS01290	COG4264	IucA IucC family
I6K89_RS01295	COG4264	IucA IucC family
I6K89_RS01335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K89_RS01350	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6K89_RS01370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K89_RS01375	COG0730	response to heat
I6K89_RS01395	COG4773	Receptor
I6K89_RS01400	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K89_RS01415	COG1131	(ABC) transporter
I6K89_RS01420	COG0842	Transport permease protein
I6K89_RS01425	COG0842	Transport permease protein
I6K89_RS01480	COG2226	methyltransferase
I6K89_RS01505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6K89_RS01540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K89_RS01550	COG0133	tryptophan synthase activity
I6K89_RS01565	COG3706	GGDEF domain
I6K89_RS01580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K89_RS01585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K89_RS01590	COG0022	dehydrogenase e1 component
I6K89_RS01595	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K89_RS01600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K89_RS01610	COG1063	alcohol dehydrogenase
I6K89_RS01615	COG3781	membrane
I6K89_RS01625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K89_RS01625	COG3453	Protein conserved in bacteria
I6K89_RS01635	COG0730	response to heat
I6K89_RS01650	COG3708	Transcriptional regulator
I6K89_RS01650	COG2207	Transcriptional regulator
I6K89_RS01655	COG1733	regulation of RNA biosynthetic process
I6K89_RS01660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6K89_RS01670	COG2188	Transcriptional regulator
I6K89_RS01685	COG4521	taurine ABC transporter
I6K89_RS01690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K89_RS01710	COG0477	Major facilitator Superfamily
I6K89_RS01720	COG1027	Aspartate ammonia-lyase
I6K89_RS01735	COG0583	DNA-binding transcription factor activity
I6K89_RS01740	COG0583	DNA-binding transcription factor activity
I6K89_RS01745	COG0183	Belongs to the thiolase family
I6K89_RS01750	COG2031	fatty acid transporter
I6K89_RS01755	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K89_RS01765	COG0583	DNA-binding transcription factor activity
I6K89_RS01775	COG2610	gluconate transmembrane transporter activity
I6K89_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS01790	COG2207	Transcriptional regulator
I6K89_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS01830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K89_RS01830	COG0543	2 iron, 2 sulfur cluster binding
I6K89_RS01835	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K89_RS01840	COG4638	Rieske (2fe-2S)
I6K89_RS01850	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K89_RS01855	COG4149	molybdate abc transporter
I6K89_RS01860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K89_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS01870	COG1535	isochorismatase
I6K89_RS01870	COG3433	isochorismatase activity
I6K89_RS01930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K89_RS01940	COG2826	transposase and inactivated derivatives, IS30 family
I6K89_RS01950	COG0753	catalase activity
I6K89_RS01960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6K89_RS01990	COG3539	Fimbrial protein
I6K89_RS02010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K89_RS02030	COG2072	flavoprotein involved in K transport
I6K89_RS02040	COG1538	Outer membrane efflux protein
I6K89_RS02045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K89_RS02050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS02055	COG0745	RESPONSE REGULATOR receiver
I6K89_RS02060	COG2205	protein histidine kinase activity
I6K89_RS02070	COG2207	Transcriptional regulator
I6K89_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS02135	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K89_RS02250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K89_RS02270	COG1120	ATPase activity
I6K89_RS02275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K89_RS02285	COG1064	alcohol dehydrogenase
I6K89_RS02300	COG2207	Transcriptional regulator
I6K89_RS02305	COG2084	Dehydrogenase
I6K89_RS02315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K89_RS02320	COG0583	DNA-binding transcription factor activity
I6K89_RS02330	COG0129	dihydroxy-acid dehydratase activity
I6K89_RS02335	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS02350	COG1566	PFAM secretion protein HlyD family protein
I6K89_RS02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K89_RS02400	COG0583	DNA-binding transcription factor activity
I6K89_RS02415	COG2188	Transcriptional regulator
I6K89_RS02445	COG3210	domain, Protein
I6K89_RS02450	COG2831	hemolysin activation secretion protein
I6K89_RS02460	COG1473	amidohydrolase
I6K89_RS02470	COG0475	glutathione-regulated potassium exporter activity
I6K89_RS02470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K89_RS02480	COG0583	DNA-binding transcription factor activity
I6K89_RS02485	COG1335	isochorismatase
I6K89_RS02495	COG1309	transcriptional regulator
I6K89_RS02525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K89_RS02535	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K89_RS02535	COG1902	pentaerythritol trinitrate reductase activity
I6K89_RS02540	COG1846	Transcriptional regulator
I6K89_RS02560	COG0753	catalase activity
I6K89_RS02575	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS02590	COG3162	membrane
I6K89_RS02600	COG3829	transcription factor binding
I6K89_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS02610	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS02630	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS02650	COG2186	Transcriptional regulator
I6K89_RS02660	COG0583	DNA-binding transcription factor activity
I6K89_RS02665	COG4948	Mandelate Racemase Muconate Lactonizing
I6K89_RS02670	COG4829	muconolactone delta-isomerase
I6K89_RS02680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K89_RS02685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K89_RS02690	COG0183	Belongs to the thiolase family
I6K89_RS02695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K89_RS02705	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS02715	COG3733	amine oxidase
I6K89_RS02725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K89_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS02745	COG4638	Rieske (2fe-2S)
I6K89_RS02765	COG0154	amidase activity
I6K89_RS02775	COG2814	Major facilitator Superfamily
I6K89_RS02800	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS02805	COG0583	DNA-binding transcription factor activity
I6K89_RS02810	COG1414	Transcriptional regulator
I6K89_RS02825	COG2391	methyltransferase activity
I6K89_RS02835	COG4993	Dehydrogenase
I6K89_RS02840	COG3659	wide pore channel activity
I6K89_RS02845	COG3420	alginic acid biosynthetic process
I6K89_RS02850	COG0710	3-dehydroquinate dehydratase activity
I6K89_RS02855	COG3485	protocatechuate 3,4-dioxygenase
I6K89_RS02860	COG3485	protocatechuate 3,4-dioxygenase
I6K89_RS02865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K89_RS02870	COG2271	Major facilitator Superfamily
I6K89_RS02875	COG0596	Alpha beta hydrolase
I6K89_RS02880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K89_RS02885	COG0183	Belongs to the thiolase family
I6K89_RS02890	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K89_RS02895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K89_RS02905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6K89_RS02910	COG2323	membrane
I6K89_RS02955	COG1902	pentaerythritol trinitrate reductase activity
I6K89_RS02955	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K89_RS02980	COG0542	response to heat
I6K89_RS02985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6K89_RS03015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K89_RS03020	COG0569	domain protein
I6K89_RS03025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K89_RS03040	COG4774	siderophore transport
I6K89_RS03045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K89_RS03055	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K89_RS03075	COG1294	oxidase, subunit
I6K89_RS03080	COG4890	Cyd operon protein YbgT
I6K89_RS03095	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6K89_RS03105	COG0552	protein localization to endoplasmic reticulum
I6K89_RS03130	COG0517	IMP dehydrogenase activity
I6K89_RS03130	COG0516	GMP reductase activity
I6K89_RS03135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K89_RS03140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K89_RS03150	COG0583	DNA-binding transcription factor activity
I6K89_RS03155	COG0024	Methionine aminopeptidase
I6K89_RS03185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K89_RS03185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K89_RS03190	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K89_RS03195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K89_RS03195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K89_RS03195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K89_RS03215	COG5001	Diguanylate cyclase
I6K89_RS03215	COG3300	MHYT domain
I6K89_RS03230	COG2135	peptidase activity
I6K89_RS03235	COG0659	secondary active sulfate transmembrane transporter activity
I6K89_RS03250	COG1113	amino acid transport
I6K89_RS03260	COG1522	sequence-specific DNA binding
I6K89_RS03285	COG1011	Hydrolase
I6K89_RS03290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K89_RS03300	COG2137	regulation of response to DNA damage stimulus
I6K89_RS03315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K89_RS03350	COG0575	Belongs to the CDS family
I6K89_RS03355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K89_RS03375	COG3852	Histidine kinase
I6K89_RS03380	COG2204	response regulator
I6K89_RS03435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K89_RS03440	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K89_RS03460	COG0697	spore germination
I6K89_RS03465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K89_RS03475	COG0303	'Molybdopterin
I6K89_RS03480	COG0315	cyclic pyranopterin monophosphate synthase activity
I6K89_RS03480	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K89_RS03495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6K89_RS03500	COG0243	molybdopterin cofactor binding
I6K89_RS03510	COG0243	molybdopterin cofactor binding
I6K89_RS03515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K89_RS03520	COG2146	nitrite reductase [NAD(P)H] activity
I6K89_RS03520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K89_RS03530	COG0745	RESPONSE REGULATOR receiver
I6K89_RS03535	COG1116	anion transmembrane transporter activity
I6K89_RS03535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K89_RS03555	COG0511	ligase activity, forming carbon-carbon bonds
I6K89_RS03570	COG2814	Major facilitator Superfamily
I6K89_RS03590	COG0069	glutamate synthase activity
I6K89_RS03610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K89_RS03620	COG1454	alcohol dehydrogenase
I6K89_RS03625	COG0824	Thioesterase
I6K89_RS03635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K89_RS03650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K89_RS03655	COG2030	dehydratase
I6K89_RS03665	COG0183	Belongs to the thiolase family
I6K89_RS03675	COG0583	DNA-binding transcription factor activity
I6K89_RS03680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K89_RS03690	COG1522	sequence-specific DNA binding
I6K89_RS03695	COG3135	benzoate transporter
I6K89_RS03705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K89_RS03730	COG0589	response to stress
I6K89_RS03735	COG0488	(ABC) transporter
I6K89_RS03755	COG4773	Receptor
I6K89_RS03790	COG0668	transmembrane transport
I6K89_RS03800	COG1309	transcriptional regulator
I6K89_RS03815	COG1605	Chorismate mutase
I6K89_RS03825	COG4221	oxidoreductase activity
I6K89_RS03835	COG0308	aminopeptidase N
I6K89_RS03855	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K89_RS03865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K89_RS03870	COG1454	alcohol dehydrogenase
I6K89_RS03890	COG0531	amino acid
I6K89_RS03895	COG4303	Ethanolamine ammonia lyase large subunit
I6K89_RS03900	COG4302	ethanolamine ammonia-lyase activity
I6K89_RS03905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K89_RS03905	COG0519	Catalyzes the synthesis of GMP from XMP
I6K89_RS03910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K89_RS03920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K89_RS03935	COG0697	spore germination
I6K89_RS03940	COG1923	regulation of RNA biosynthetic process
I6K89_RS03950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6K89_RS03955	COG0802	atpase or kinase
I6K89_RS03975	COG1187	pseudouridine synthase activity
I6K89_RS03990	COG0583	DNA-binding transcription factor activity
I6K89_RS04005	COG2814	Major facilitator Superfamily
I6K89_RS04010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K89_RS04035	COG0729	surface antigen
I6K89_RS04055	COG0174	glutamine synthetase
I6K89_RS04060	COG0745	RESPONSE REGULATOR receiver
I6K89_RS04065	COG2205	protein histidine kinase activity
I6K89_RS04075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6K89_RS04080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6K89_RS04105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K89_RS04110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K89_RS04115	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS04130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K89_RS04135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K89_RS04155	COG0583	DNA-binding transcription factor activity
I6K89_RS04170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K89_RS04180	COG3658	cytochrome
I6K89_RS04185	COG1215	transferase activity, transferring glycosyl groups
I6K89_RS04190	COG1649	PFAM Uncharacterised BCR, COG1649
I6K89_RS04190	COG0726	polysaccharide deacetylase
I6K89_RS04215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K89_RS04220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K89_RS04230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K89_RS04255	COG0305	Participates in initiation and elongation during chromosome replication
I6K89_RS04260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K89_RS04270	COG1305	Transglutaminase-like
I6K89_RS04280	COG2308	Evidence 4 Homologs of previously reported genes of
I6K89_RS04310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6K89_RS04315	COG0138	bifunctional purine biosynthesis protein purh
I6K89_RS04320	COG0151	Belongs to the GarS family
I6K89_RS04325	COG1464	Belongs to the NlpA lipoprotein family
I6K89_RS04330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K89_RS04335	COG2011	ABC-type metal ion transport system permease component
I6K89_RS04340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K89_RS04405	COG2433	Pfam Transposase IS66
I6K89_RS04415	COG3173	Aminoglycoside phosphotransferase
I6K89_RS04420	COG0488	(ABC) transporter
I6K89_RS04435	COG0482	sulfurtransferase activity
I6K89_RS04515	COG1063	alcohol dehydrogenase
I6K89_RS04525	COG1309	transcriptional regulator
I6K89_RS04545	COG0038	chloride channel
I6K89_RS04550	COG4770	biotin carboxylase activity
I6K89_RS04570	COG1914	H( )-stimulated, divalent metal cation uptake system
I6K89_RS04575	COG0583	DNA-binding transcription factor activity
I6K89_RS04635	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K89_RS04655	COG2814	Major facilitator Superfamily
I6K89_RS04665	COG1560	Kdo2-lipid A biosynthetic process
I6K89_RS04675	COG5006	permease, DMT superfamily
I6K89_RS04680	COG1522	sequence-specific DNA binding
I6K89_RS04695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K89_RS04705	COG4122	O-methyltransferase activity
I6K89_RS04735	COG1538	Outer membrane efflux protein
I6K89_RS04740	COG1137	ATPase activity
I6K89_RS04745	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K89_RS04755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K89_RS04760	COG0517	IMP dehydrogenase activity
I6K89_RS04760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K89_RS04795	COG2814	Major facilitator Superfamily
I6K89_RS04830	COG1278	Cold shock
I6K89_RS04835	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS04865	COG1570	exodeoxyribonuclease VII activity
I6K89_RS04915	COG0583	DNA-binding transcription factor activity
I6K89_RS04920	COG4638	Rieske (2fe-2S)
I6K89_RS04925	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K89_RS04930	COG0543	2 iron, 2 sulfur cluster binding
I6K89_RS04930	COG0633	Ferredoxin
I6K89_RS04935	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS04940	COG3135	benzoate transporter
I6K89_RS04945	COG2814	Major facilitator Superfamily
I6K89_RS04960	COG1643	Atp-dependent helicase
I6K89_RS04965	COG0450	alkyl hydroperoxide reductase
I6K89_RS04975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6K89_RS04985	COG3634	alkyl hydroperoxide reductase activity
I6K89_RS05005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6K89_RS05010	COG0625	glutathione transferase activity
I6K89_RS05020	COG2885	chlorophyll binding
I6K89_RS05055	COG0542	response to heat
I6K89_RS05070	COG1765	OsmC-like protein
I6K89_RS05090	COG0667	Aldo Keto reductase
I6K89_RS05105	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6K89_RS05115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K89_RS05125	COG0527	aspartate kinase activity
I6K89_RS05135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6K89_RS05145	COG3038	cytochrome b561
I6K89_RS05150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6K89_RS05155	COG2252	PERMEase
I6K89_RS05165	COG2072	flavoprotein involved in K transport
I6K89_RS05180	COG1741	Belongs to the pirin family
I6K89_RS05185	COG1309	transcriptional regulator
I6K89_RS05195	COG0300	oxidoreductase activity
I6K89_RS05215	COG1113	amino acid transport
I6K89_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS05255	COG0531	amino acid
I6K89_RS05265	COG1113	amino acid transport
I6K89_RS05305	COG3209	COG3209 Rhs family protein
I6K89_RS05335	COG4269	membrane
I6K89_RS05350	COG1902	pentaerythritol trinitrate reductase activity
I6K89_RS05350	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K89_RS05360	COG3706	GGDEF domain
I6K89_RS05360	COG4251	negative regulation of phosphorylation
I6K89_RS05360	COG5001	Diguanylate cyclase
I6K89_RS05360	COG2203	Gaf domain
I6K89_RS05370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K89_RS05390	COG4172	Belongs to the ABC transporter superfamily
I6K89_RS05395	COG4239	(ABC) transporter, permease
I6K89_RS05400	COG4174	ABC transporter (Permease)
I6K89_RS05405	COG4166	transmembrane transport
I6K89_RS05410	COG1388	LysM domain
I6K89_RS05410	COG1388	LysM domain
I6K89_RS05410	COG0741	lytic transglycosylase activity
I6K89_RS05410	COG0741	lytic transglycosylase activity
I6K89_RS05415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K89_RS05455	COG0583	DNA-binding transcription factor activity
I6K89_RS05460	COG1279	arginine transmembrane transporter activity
I6K89_RS05480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K89_RS05485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K89_RS05490	COG0006	proline dipeptidase activity
I6K89_RS05575	COG1196	nuclear chromosome segregation
I6K89_RS05575	COG0741	lytic transglycosylase activity
I6K89_RS05575	COG0739	heme binding
I6K89_RS05635	COG4695	Portal protein
I6K89_RS05730	COG0305	Participates in initiation and elongation during chromosome replication
I6K89_RS05745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K89_RS05800	COG2194	sulfuric ester hydrolase activity
I6K89_RS05850	COG0739	heme binding
I6K89_RS06175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K89_RS06200	COG3384	dioxygenase
I6K89_RS06210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K89_RS06215	COG2878	Part of a membrane complex involved in electron transport
I6K89_RS06220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K89_RS06245	COG0768	penicillin binding
I6K89_RS06250	COG0742	ribosomal rna small subunit methyltransferase
I6K89_RS06265	COG0830	nickel cation binding
I6K89_RS06310	COG1253	flavin adenine dinucleotide binding
I6K89_RS06315	COG2851	Citrate transporter
I6K89_RS06365	COG1773	rubredoxin
I6K89_RS06370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K89_RS06380	COG0583	DNA-binding transcription factor activity
I6K89_RS06405	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K89_RS06410	COG4181	ATPase activity
I6K89_RS06455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K89_RS06475	COG0306	phosphate transporter
I6K89_RS06485	COG3958	Transketolase
I6K89_RS06490	COG3959	Transketolase, thiamine diphosphate binding domain
I6K89_RS06495	COG2271	Major facilitator Superfamily
I6K89_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS06505	COG0583	DNA-binding transcription factor activity
I6K89_RS06520	COG2223	nitrite transmembrane transporter activity
I6K89_RS06525	COG2207	Transcriptional regulator
I6K89_RS06530	COG2066	Belongs to the glutaminase family
I6K89_RS06535	COG0242	peptide deformylase activity
I6K89_RS06540	COG0477	Major facilitator Superfamily
I6K89_RS06550	COG0028	Belongs to the TPP enzyme family
I6K89_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS06570	COG2267	carboxylic ester hydrolase activity
I6K89_RS06580	COG2271	Major facilitator Superfamily
I6K89_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS06615	COG1414	Transcriptional regulator
I6K89_RS06630	COG1024	Enoyl-CoA hydratase
I6K89_RS06640	COG1215	transferase activity, transferring glycosyl groups
I6K89_RS06645	COG1649	PFAM Uncharacterised BCR, COG1649
I6K89_RS06645	COG0726	polysaccharide deacetylase
I6K89_RS06655	COG4681	YaeQ
I6K89_RS06665	COG0523	cobalamin synthesis protein
I6K89_RS06675	COG1607	acyl-coa hydrolase
I6K89_RS06685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K89_RS06690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K89_RS06695	COG1309	transcriptional regulator
I6K89_RS06720	COG2040	homocysteine
I6K89_RS06725	COG0531	amino acid
I6K89_RS06780	COG1595	DNA-templated transcription, initiation
I6K89_RS06790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K89_RS06795	COG0477	Major facilitator Superfamily
I6K89_RS06815	COG0084	hydrolase, TatD family'
I6K89_RS06840	COG2826	transposase and inactivated derivatives, IS30 family
I6K89_RS06855	COG0629	single-stranded DNA binding
I6K89_RS06910	COG0582	viral genome integration into host DNA
I6K89_RS06920	COG0405	Gamma-glutamyltransferase
I6K89_RS06925	COG2814	Major facilitator Superfamily
I6K89_RS06935	COG2050	protein possibly involved in aromatic compounds catabolism
I6K89_RS06950	COG1090	epimerase
I6K89_RS06970	COG0420	3'-5' exonuclease activity
I6K89_RS06995	COG0735	belongs to the Fur family
I6K89_RS07000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K89_RS07020	COG0121	glutamine amidotransferase
I6K89_RS07035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K89_RS07045	COG0210	DNA helicase
I6K89_RS07050	COG2885	chlorophyll binding
I6K89_RS07055	COG0204	Acyl-transferase
I6K89_RS07070	COG2894	cell division
I6K89_RS07090	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS07095	COG1674	ftsk spoiiie
I6K89_RS07095	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K89_RS07100	COG0492	ferredoxin-NADP+ reductase activity
I6K89_RS07105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6K89_RS07115	COG0456	acetyltransferase
I6K89_RS07160	COG1981	membrane
I6K89_RS07175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K89_RS07175	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6K89_RS07195	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS07205	COG0657	acetylesterase activity
I6K89_RS07215	COG0473	3-isopropylmalate dehydrogenase activity
I6K89_RS07220	COG0583	DNA-binding transcription factor activity
I6K89_RS07240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K89_RS07265	COG0564	pseudouridine synthase activity
I6K89_RS07275	COG0358	DNA primase activity
I6K89_RS07290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6K89_RS07320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K89_RS07350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6K89_RS07360	COG0352	thiamine-phosphate diphosphorylase activity
I6K89_RS07360	COG0351	phosphomethylpyrimidine kinase
I6K89_RS07360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K89_RS07365	COG1652	LysM domain
I6K89_RS07390	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K89_RS07395	COG3101	peptidyl-lysine hydroxylation
I6K89_RS07400	COG0009	L-threonylcarbamoyladenylate synthase
I6K89_RS07405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6K89_RS07410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6K89_RS07425	COG4106	trans-aconitate 2-methyltransferase activity
I6K89_RS07440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K89_RS07440	COG2226	methyltransferase
I6K89_RS07440	COG0596	Alpha beta hydrolase
I6K89_RS07445	COG1877	trehalose-phosphatase activity
I6K89_RS07450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6K89_RS07455	COG2223	nitrite transmembrane transporter activity
I6K89_RS07475	COG1196	nuclear chromosome segregation
I6K89_RS07485	COG0730	response to heat
I6K89_RS07500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K89_RS07510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K89_RS07560	COG0489	protein tyrosine kinase activity
I6K89_RS07570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K89_RS07570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K89_RS07600	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6K89_RS07605	COG2081	HI0933 family
I6K89_RS07615	COG0668	transmembrane transport
I6K89_RS07635	COG0583	DNA-binding transcription factor activity
I6K89_RS07655	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K89_RS07660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K89_RS07690	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K89_RS07730	COG0745	RESPONSE REGULATOR receiver
I6K89_RS07750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K89_RS07760	COG2205	protein histidine kinase activity
I6K89_RS07830	COG4993	Dehydrogenase
I6K89_RS07855	COG0384	phenazine biosynthesis protein PhzF
I6K89_RS07875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K89_RS07890	COG0583	DNA-binding transcription factor activity
I6K89_RS07920	COG0583	DNA-binding transcription factor activity
I6K89_RS07935	COG0583	DNA-binding transcription factor activity
I6K89_RS07940	COG1053	succinate dehydrogenase
I6K89_RS07950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K89_RS07955	COG2814	Major facilitator Superfamily
I6K89_RS07960	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS07965	COG0583	DNA-binding transcription factor activity
I6K89_RS07970	COG1063	alcohol dehydrogenase
I6K89_RS08000	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K89_RS08005	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6K89_RS08010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K89_RS08025	COG3667	copper resistance
I6K89_RS08030	COG2132	Multicopper oxidase
I6K89_RS08040	COG0561	phosphatase activity
I6K89_RS08045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K89_RS08070	COG1214	PFAM Peptidase M22, glycoprotease
I6K89_RS08120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K89_RS08130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K89_RS08135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6K89_RS08140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K89_RS08200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K89_RS08210	COG1846	Transcriptional regulator
I6K89_RS08215	COG1764	response to oxidative stress
I6K89_RS08255	COG0037	tRNA processing
I6K89_RS08265	COG0248	Ppx GppA phosphatase
I6K89_RS08295	COG0072	phenylalanine-tRNA ligase activity
I6K89_RS08335	COG1238	metal cluster binding
I6K89_RS08340	COG0625	glutathione transferase activity
I6K89_RS08355	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS08360	COG3028	Belongs to the UPF0307 family
I6K89_RS08365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K89_RS08385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K89_RS08390	COG0617	tRNA 3'-terminal CCA addition
I6K89_RS08395	COG1555	photosystem II stabilization
I6K89_RS08400	COG3956	TIGRFAM MazG family protein
I6K89_RS08410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K89_RS08430	COG0784	Response regulator, receiver
I6K89_RS08430	COG2205	protein histidine kinase activity
I6K89_RS08430	COG5002	protein histidine kinase activity
I6K89_RS08435	COG1024	Enoyl-CoA hydratase
I6K89_RS08440	COG2084	Dehydrogenase
I6K89_RS08445	COG3622	Belongs to the hyi family
I6K89_RS08475	COG0697	spore germination
I6K89_RS08485	COG2814	Major facilitator Superfamily
I6K89_RS08490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K89_RS08500	COG0583	DNA-binding transcription factor activity
I6K89_RS08510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K89_RS08525	COG0084	hydrolase, TatD family'
I6K89_RS08540	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6K89_RS08570	COG0440	acetolactate synthase activity
I6K89_RS08575	COG0028	Belongs to the TPP enzyme family
I6K89_RS08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS08605	COG1136	(ABC) transporter
I6K89_RS08605	COG0577	efflux transmembrane transporter activity
I6K89_RS08610	COG1538	Outer membrane efflux protein
I6K89_RS08625	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K89_RS08630	COG1162	GTPase activity
I6K89_RS08640	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K89_RS08660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K89_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS08705	COG2986	histidine ammonia-lyase
I6K89_RS08720	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS08730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K89_RS08775	COG1426	Protein conserved in bacteria
I6K89_RS08810	COG0793	Belongs to the peptidase S41A family
I6K89_RS08825	COG2267	carboxylic ester hydrolase activity
I6K89_RS08835	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS08840	COG3265	gluconokinase activity
I6K89_RS08850	COG0800	Aldolase
I6K89_RS08860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K89_RS08865	COG0857	belongs to the CobB CobQ family
I6K89_RS08865	COG0280	phosphate acetyltransferase
I6K89_RS08870	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K89_RS08870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K89_RS08890	COG0740	serine-type endopeptidase activity
I6K89_RS08900	COG4774	siderophore transport
I6K89_RS08910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K89_RS08920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K89_RS08920	COG2813	Specifically methylates the guanine in position
I6K89_RS09020	COG0788	formyltetrahydrofolate deformylase activity
I6K89_RS09045	COG4651	solute:proton antiporter activity
I6K89_RS09045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K89_RS09065	COG0724	RNA recognition motif
I6K89_RS09070	COG0210	DNA helicase
I6K89_RS09095	COG1733	regulation of RNA biosynthetic process
I6K89_RS09105	COG2900	Belongs to the SlyX family
I6K89_RS09110	COG0488	(ABC) transporter
I6K89_RS09115	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS09120	COG1560	Kdo2-lipid A biosynthetic process
I6K89_RS09130	COG1301	dicarboxylic acid transport
I6K89_RS09185	COG0473	3-isopropylmalate dehydrogenase activity
I6K89_RS09250	COG0583	DNA-binding transcription factor activity
I6K89_RS09260	COG0625	glutathione transferase activity
I6K89_RS09265	COG2378	regulation of single-species biofilm formation
I6K89_RS09270	COG0546	phosphoglycolate phosphatase activity
I6K89_RS09280	COG1530	ribonuclease E activity
I6K89_RS09285	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS09300	COG0583	DNA-binding transcription factor activity
I6K89_RS09305	COG4221	oxidoreductase activity
I6K89_RS09310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K89_RS09320	COG0534	Mate efflux family protein
I6K89_RS09335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K89_RS09375	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6K89_RS09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K89_RS09395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K89_RS09405	COG0644	oxidoreductase
I6K89_RS09405	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K89_RS09410	COG0425	Belongs to the sulfur carrier protein TusA family
I6K89_RS09415	COG4535	Mg2 and Co2 transporter CorC
I6K89_RS09425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K89_RS09445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K89_RS09450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K89_RS09450	COG0475	glutathione-regulated potassium exporter activity
I6K89_RS09455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6K89_RS09465	COG0484	heat shock protein binding
I6K89_RS09470	COG0789	Transcriptional regulator
I6K89_RS09475	COG0598	Magnesium transport protein CorA
I6K89_RS09490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K89_RS09495	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K89_RS09500	COG1074	ATP-dependent DNA helicase activity
I6K89_RS09505	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K89_RS09525	COG2226	methyltransferase
I6K89_RS09540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K89_RS09545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K89_RS09560	COG2111	Na H antiporter
I6K89_RS09560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K89_RS09565	COG1006	Multisubunit Na H antiporter MnhC subunit
I6K89_RS09570	COG0651	ATP synthesis coupled electron transport
I6K89_RS09575	COG1863	multisubunit Na H antiporter MnhE subunit
I6K89_RS09580	COG2212	antiporter activity
I6K89_RS09585	COG1320	monovalent cation:proton antiporter activity
I6K89_RS09600	COG0195	Participates in both transcription termination and antitermination
I6K89_RS09650	COG0237	dephospho-CoA kinase activity
I6K89_RS09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K89_RS09675	COG0497	DNA recombination
I6K89_RS09685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6K89_RS09715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K89_RS09715	COG2169	Transcriptional regulator
I6K89_RS09720	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K89_RS09785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K89_RS09800	COG0326	Molecular chaperone. Has ATPase activity
I6K89_RS09815	COG2056	Na+-H+ antiporter family
I6K89_RS09820	COG0596	Alpha beta hydrolase
I6K89_RS09915	COG0546	phosphoglycolate phosphatase activity
I6K89_RS09920	COG1716	ATPase activity
I6K89_RS09965	COG0181	hydroxymethylbilane synthase activity
I6K89_RS09975	COG3275	phosphorelay sensor kinase activity
I6K89_RS10000	COG0697	spore germination
I6K89_RS10025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K89_RS10030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K89_RS10035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K89_RS10040	COG0772	Belongs to the SEDS family
I6K89_RS10065	COG4974	Belongs to the 'phage' integrase family
I6K89_RS10070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K89_RS10080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K89_RS10090	COG2197	response regulator
I6K89_RS10105	COG0793	Belongs to the peptidase S41A family
I6K89_RS10110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6K89_RS10115	COG0795	lipopolysaccharide-transporting ATPase activity
I6K89_RS10155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K89_RS10155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K89_RS10165	COG0004	ammonium transporteR
I6K89_RS10170	COG0347	Belongs to the P(II) protein family
I6K89_RS10180	COG0606	chelatase, subunit chli
I6K89_RS10260	COG0659	secondary active sulfate transmembrane transporter activity
I6K89_RS10265	COG0589	response to stress
I6K89_RS10295	COG0606	chelatase, subunit chli
I6K89_RS10300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K89_RS10310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K89_RS10325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K89_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS10350	COG0477	Major facilitator Superfamily
I6K89_RS10355	COG2860	membrane
I6K89_RS10365	COG1253	flavin adenine dinucleotide binding
I6K89_RS10385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K89_RS10420	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6K89_RS10430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K89_RS10465	COG1309	transcriptional regulator
I6K89_RS10500	COG0758	DNA mediated transformation
I6K89_RS10510	COG0697	spore germination
I6K89_RS10515	COG1309	transcriptional regulator
I6K89_RS10530	COG0386	Belongs to the glutathione peroxidase family
I6K89_RS10595	COG1121	(ABC) transporter
I6K89_RS10600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K89_RS10605	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS10610	COG2837	iron assimilation
I6K89_RS10615	COG0281	malic enzyme
I6K89_RS10660	COG0519	Catalyzes the synthesis of GMP from XMP
I6K89_RS10660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K89_RS10665	COG4399	Belongs to the UPF0754 family
I6K89_RS10670	COG2259	Doxx family
I6K89_RS10675	COG0586	Pfam SNARE associated Golgi protein
I6K89_RS10690	COG1192	Involved in chromosome partitioning
I6K89_RS10700	COG0271	Belongs to the BolA IbaG family
I6K89_RS10740	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS10740	COG3321	synthase
I6K89_RS10740	COG0300	oxidoreductase activity
I6K89_RS10740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K89_RS10740	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS10745	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS10755	COG2197	response regulator
I6K89_RS10765	COG3916	Acyl-homoserine-lactone synthase
I6K89_RS10770	COG0477	Major facilitator Superfamily
I6K89_RS10775	COG1024	Enoyl-CoA hydratase
I6K89_RS10780	COG1024	Enoyl-CoA hydratase
I6K89_RS10785	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS10790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K89_RS10810	COG1113	amino acid transport
I6K89_RS10815	COG1113	amino acid transport
I6K89_RS10820	COG0251	oxidation-reduction process
I6K89_RS10860	COG0564	pseudouridine synthase activity
I6K89_RS10905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K89_RS10920	COG1802	Transcriptional regulator
I6K89_RS10930	COG1448	Aminotransferase
I6K89_RS10935	COG0277	FAD linked oxidase domain protein
I6K89_RS10945	COG2186	Transcriptional regulator
I6K89_RS10955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K89_RS10960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K89_RS10975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K89_RS10980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K89_RS11005	COG2244	polysaccharide biosynthetic process
I6K89_RS11010	COG1083	cytidylyl-transferase
I6K89_RS11015	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6K89_RS11025	COG2089	acid synthase
I6K89_RS11030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K89_RS11035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K89_RS11045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K89_RS11050	COG1596	polysaccharide export
I6K89_RS11075	COG0728	peptidoglycan biosynthetic process
I6K89_RS11080	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K89_RS11135	COG0546	phosphoglycolate phosphatase activity
I6K89_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS11160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K89_RS11165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K89_RS11170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K89_RS11175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K89_RS11180	COG1116	anion transmembrane transporter activity
I6K89_RS11185	COG1309	transcriptional regulator
I6K89_RS11190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K89_RS11200	COG0196	riboflavin kinase activity
I6K89_RS11205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6K89_RS11215	COG1047	Peptidyl-prolyl cis-trans
I6K89_RS11255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K89_RS11260	COG0657	acetylesterase activity
I6K89_RS11310	COG2951	lytic endotransglycosylase activity
I6K89_RS11315	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K89_RS11330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K89_RS11340	COG0671	phosphoesterase, PA-phosphatase related
I6K89_RS11345	COG0861	Integral membrane protein TerC family
I6K89_RS11355	COG0754	glutathionylspermidine amidase activity
I6K89_RS11365	COG0402	S-adenosylhomocysteine deaminase activity
I6K89_RS11380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K89_RS11385	COG1230	cation diffusion facilitator family transporter
I6K89_RS11400	COG0706	membrane insertase activity
I6K89_RS11425	COG0592	DNA-directed DNA polymerase activity
I6K89_RS11435	COG0187	DNA topoisomerase II activity
I6K89_RS11445	COG0586	Pfam SNARE associated Golgi protein
I6K89_RS11455	COG0488	(ABC) transporter
I6K89_RS11480	COG0596	Alpha beta hydrolase
I6K89_RS11485	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6K89_RS11490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6K89_RS11530	COG0733	neurotransmitter:sodium symporter activity
I6K89_RS11565	COG0583	DNA-binding transcription factor activity
I6K89_RS11570	COG2233	PERMEase
I6K89_RS11585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS11620	COG2814	Major facilitator Superfamily
I6K89_RS11625	COG0656	L-ascorbic acid biosynthetic process
I6K89_RS11630	COG0583	DNA-binding transcription factor activity
I6K89_RS11645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K89_RS11650	COG1064	alcohol dehydrogenase
I6K89_RS11655	COG2818	Glycosylase
I6K89_RS11670	COG1194	a g-specific adenine glycosylase
I6K89_RS11690	COG2983	Belongs to the UPF0260 family
I6K89_RS11695	COG2133	pyrroloquinoline quinone binding
I6K89_RS11700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K89_RS11705	COG2116	formate transmembrane transporter activity
I6K89_RS11725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K89_RS11730	COG1335	isochorismatase
I6K89_RS11735	COG0385	Bile acid
I6K89_RS11740	COG0534	Mate efflux family protein
I6K89_RS11745	COG1683	Conserved Protein
I6K89_RS11765	COG0625	glutathione transferase activity
I6K89_RS11775	COG1113	amino acid transport
I6K89_RS11785	COG0523	cobalamin synthesis protein
I6K89_RS11795	COG2188	Transcriptional regulator
I6K89_RS11825	COG0010	Belongs to the arginase family
I6K89_RS11840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K89_RS11845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K89_RS11855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K89_RS11860	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K89_RS11960	COG0534	Mate efflux family protein
I6K89_RS11965	COG0436	Aminotransferase
I6K89_RS11970	COG2733	membrane
I6K89_RS11985	COG2918	glutathione biosynthetic process
I6K89_RS12000	COG1388	LysM domain
I6K89_RS12000	COG0791	NLP P60 protein
I6K89_RS12020	COG3150	esterase
I6K89_RS12030	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS12035	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6K89_RS12045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K89_RS12055	COG2233	PERMEase
I6K89_RS12060	COG2351	hydroxyisourate hydrolase activity
I6K89_RS12095	COG3706	GGDEF domain
I6K89_RS12110	COG1393	Belongs to the ArsC family
I6K89_RS12115	COG0708	Exodeoxyribonuclease III
I6K89_RS12135	COG0189	ligase activity
I6K89_RS12155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K89_RS12165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K89_RS12180	COG4942	peptidase
I6K89_RS12190	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K89_RS12200	COG2119	membrane
I6K89_RS12205	COG4774	siderophore transport
I6K89_RS12210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K89_RS12210	COG0426	domain, Protein
I6K89_RS12235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K89_RS12255	COG1902	pentaerythritol trinitrate reductase activity
I6K89_RS12260	COG1519	Transferase
I6K89_RS12265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K89_RS12270	COG0668	transmembrane transport
I6K89_RS12280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K89_RS12285	COG1335	isochorismatase
I6K89_RS12290	COG1522	sequence-specific DNA binding
I6K89_RS12315	COG2205	protein histidine kinase activity
I6K89_RS12315	COG2198	Histidine kinase
I6K89_RS12315	COG0784	Response regulator, receiver
I6K89_RS12320	COG3162	membrane
I6K89_RS12325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K89_RS12335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K89_RS12355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K89_RS12360	COG1309	transcriptional regulator
I6K89_RS12380	COG0351	phosphomethylpyrimidine kinase
I6K89_RS12380	COG0352	thiamine-phosphate diphosphorylase activity
I6K89_RS12380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K89_RS12390	COG2814	Major facilitator Superfamily
I6K89_RS12405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K89_RS12415	COG1113	amino acid transport
I6K89_RS12425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K89_RS12430	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS12440	COG1335	isochorismatase
I6K89_RS12470	COG2814	Major facilitator Superfamily
I6K89_RS12475	COG0583	DNA-binding transcription factor activity
I6K89_RS12495	COG0667	Aldo Keto reductase
I6K89_RS12530	COG1733	regulation of RNA biosynthetic process
I6K89_RS12535	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K89_RS12600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K89_RS12615	COG2329	Antibiotic biosynthesis monooxygenase
I6K89_RS12645	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K89_RS12675	COG0427	acetyl-CoA hydrolase
I6K89_RS12700	COG0659	secondary active sulfate transmembrane transporter activity
I6K89_RS12705	COG4221	oxidoreductase activity
I6K89_RS12710	COG2873	o-acetylhomoserine
I6K89_RS12715	COG0488	(ABC) transporter
I6K89_RS12800	COG0833	amino acid
I6K89_RS12845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K89_RS12850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K89_RS12865	COG2226	methyltransferase
I6K89_RS12915	COG0067	glutamate synthase
I6K89_RS12915	COG0069	glutamate synthase activity
I6K89_RS12915	COG0070	glutamate synthase
I6K89_RS12920	COG0493	'glutamate synthase
I6K89_RS12930	COG1704	LemA family
I6K89_RS12935	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K89_RS12955	COG3307	-O-antigen
I6K89_RS12975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K89_RS12990	COG0194	GDP metabolic process
I6K89_RS13040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6K89_RS13060	COG5380	lipid catabolic process
I6K89_RS13065	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6K89_RS13090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K89_RS13095	COG0277	FAD linked oxidase domain protein
I6K89_RS13105	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K89_RS13110	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K89_RS13125	COG1289	transmembrane transporter activity
I6K89_RS13135	COG0628	permease
I6K89_RS13140	COG1192	Involved in chromosome partitioning
I6K89_RS13170	COG0833	amino acid
I6K89_RS13175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K89_RS13180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K89_RS13190	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS13230	COG0583	DNA-binding transcription factor activity
I6K89_RS13275	COG0517	IMP dehydrogenase activity
I6K89_RS13280	COG1983	PspC domain protein
I6K89_RS13290	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS13305	COG0408	coproporphyrinogen oxidase activity
I6K89_RS13325	COG0513	Belongs to the DEAD box helicase family
I6K89_RS13335	COG1127	ABC transporter
I6K89_RS13340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K89_RS13350	COG2854	intermembrane phospholipid transfer
I6K89_RS13360	COG0598	Magnesium transport protein CorA
I6K89_RS13370	COG0494	nUDIX hydrolase
I6K89_RS13375	COG1040	competence protein
I6K89_RS13380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K89_RS13400	COG1946	Acyl-CoA thioesterase
I6K89_RS13405	COG1301	dicarboxylic acid transport
I6K89_RS13420	COG1959	2 iron, 2 sulfur cluster binding
I6K89_RS13425	COG1017	nitric oxide dioxygenase activity
I6K89_RS13425	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K89_RS13430	COG0433	COG0433 Predicted ATPase
I6K89_RS13435	COG0626	cystathionine gamma-synthase activity
I6K89_RS13590	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS13595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K89_RS13625	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K89_RS13630	COG0339	signal peptide processing
I6K89_RS13635	COG0557	exoribonuclease II activity
I6K89_RS13680	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K89_RS13685	COG2169	Transcriptional regulator
I6K89_RS13690	COG0697	spore germination
I6K89_RS13695	COG1295	ribonuclease BN
I6K89_RS13730	COG1702	phosphate starvation-inducible protein PhoH
I6K89_RS13740	COG0741	lytic transglycosylase activity
I6K89_RS13740	COG0739	heme binding
I6K89_RS13740	COG1196	nuclear chromosome segregation
I6K89_RS13770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K89_RS13775	COG1183	phosphatidylcholine synthase activity
I6K89_RS13820	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS13825	COG1309	transcriptional regulator
I6K89_RS13840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K89_RS13845	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS13865	COG2969	positive regulation of protein catabolic process
I6K89_RS13875	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6K89_RS13890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K89_RS13895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K89_RS13915	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K89_RS13925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K89_RS13930	COG1408	metallophosphoesterase
I6K89_RS13940	COG2199	diguanylate cyclase activity
I6K89_RS14000	COG1607	acyl-coa hydrolase
I6K89_RS14030	COG2350	Protein conserved in bacteria
I6K89_RS14040	COG0613	PHP domain protein
I6K89_RS14045	COG3781	membrane
I6K89_RS14055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K89_RS14060	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K89_RS14070	COG1862	Preprotein translocase
I6K89_RS14100	COG2205	protein histidine kinase activity
I6K89_RS14105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6K89_RS14125	COG0726	polysaccharide deacetylase
I6K89_RS14130	COG0463	Glycosyl transferase, family 2
I6K89_RS14135	COG0438	transferase activity, transferring glycosyl groups
I6K89_RS14200	COG0625	glutathione transferase activity
I6K89_RS14205	COG0583	DNA-binding transcription factor activity
I6K89_RS14210	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS14215	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS14225	COG2205	protein histidine kinase activity
I6K89_RS14230	COG0745	RESPONSE REGULATOR receiver
I6K89_RS14235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6K89_RS14255	COG2096	Adenosyltransferase
I6K89_RS14305	COG0285	dihydrofolate synthase activity
I6K89_RS14325	COG0450	alkyl hydroperoxide reductase
I6K89_RS14340	COG0477	Major facilitator Superfamily
I6K89_RS14345	COG1272	protein, Hemolysin III
I6K89_RS14375	COG0183	Belongs to the thiolase family
I6K89_RS14380	COG2207	Transcriptional regulator
I6K89_RS14400	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K89_RS14420	COG0183	Belongs to the thiolase family
I6K89_RS14430	COG2885	chlorophyll binding
I6K89_RS14430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K89_RS14440	COG1690	Belongs to the RtcB family
I6K89_RS14445	COG0833	amino acid
I6K89_RS14455	COG2233	PERMEase
I6K89_RS14460	COG1217	gtp-binding protein TYPA
I6K89_RS14485	COG2094	Belongs to the DNA glycosylase MPG family
I6K89_RS14490	COG4772	TonB-dependent receptor
I6K89_RS14505	COG1902	pentaerythritol trinitrate reductase activity
I6K89_RS14520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K89_RS14525	COG0354	folic acid binding
I6K89_RS14535	COG3189	MarR family transcriptional regulator
I6K89_RS14540	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K89_RS14545	COG3422	double-strand break repair
I6K89_RS14585	COG0840	transmembrane signaling receptor activity
I6K89_RS14605	COG5510	response to toxic substance
I6K89_RS14615	COG2832	Protein of unknown function (DUF454)
I6K89_RS14620	COG1376	ErfK ybiS ycfS ynhG family protein
I6K89_RS14660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6K89_RS14670	COG1289	transmembrane transporter activity
I6K89_RS14675	COG2814	Major facilitator Superfamily
I6K89_RS14695	COG1115	amino acid carrier protein
I6K89_RS14700	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K89_RS14705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K89_RS14710	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K89_RS14740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K89_RS14750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K89_RS14755	COG1077	Cell shape determining protein MreB Mrl
I6K89_RS14760	COG1792	Involved in formation and maintenance of cell shape
I6K89_RS14765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K89_RS14770	COG0424	maF-like protein
I6K89_RS14775	COG1530	ribonuclease E activity
I6K89_RS14785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K89_RS14805	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K89_RS14830	COG2207	Transcriptional regulator
I6K89_RS14850	COG1113	amino acid transport
I6K89_RS14855	COG2828	Protein conserved in bacteria
I6K89_RS14860	COG0142	geranyltranstransferase activity
I6K89_RS14865	COG2315	Protein conserved in bacteria
I6K89_RS14880	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K89_RS14900	COG2194	sulfuric ester hydrolase activity
I6K89_RS14905	COG0745	RESPONSE REGULATOR receiver
I6K89_RS14910	COG0642	Histidine kinase
I6K89_RS14920	COG0004	ammonium transporteR
I6K89_RS14925	COG0583	DNA-binding transcription factor activity
I6K89_RS14945	COG0525	valine-tRNA ligase activity
I6K89_RS14955	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS14965	COG0393	Putative heavy-metal-binding
I6K89_RS14970	COG0393	Putative heavy-metal-binding
I6K89_RS14975	COG1538	Outer membrane efflux protein
I6K89_RS14985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS14990	COG0671	phosphoesterase, PA-phosphatase related
I6K89_RS15020	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6K89_RS15035	COG1648	precorrin-2 dehydrogenase activity
I6K89_RS15035	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6K89_RS15040	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K89_RS15045	COG1733	regulation of RNA biosynthetic process
I6K89_RS15055	COG0531	amino acid
I6K89_RS15070	COG0321	lipoyl(octanoyl) transferase activity
I6K89_RS15075	COG2921	Belongs to the UPF0250 family
I6K89_RS15115	COG2009	succinate dehydrogenase
I6K89_RS15120	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K89_RS15125	COG1053	succinate dehydrogenase
I6K89_RS15130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K89_RS15155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K89_RS15175	COG2354	Protein conserved in bacteria
I6K89_RS15180	COG2321	neutral zinc metallopeptidase
I6K89_RS15220	COG2843	Capsule synthesis protein
I6K89_RS15235	COG0589	response to stress
I6K89_RS15255	COG0505	Belongs to the CarA family
I6K89_RS15280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K89_RS15285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K89_RS15335	COG0477	Major facilitator Superfamily
I6K89_RS15340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K89_RS15355	COG1597	lipid kinase activity
I6K89_RS15360	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K89_RS15390	COG0584	glycerophosphoryl diester phosphodiesterase
I6K89_RS15410	COG0741	lytic transglycosylase activity
I6K89_RS15430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K89_RS15445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K89_RS15450	COG2826	transposase and inactivated derivatives, IS30 family
I6K89_RS15475	COG0778	Nitroreductase
I6K89_RS15490	COG1929	Belongs to the glycerate kinase type-1 family
I6K89_RS15495	COG0243	molybdopterin cofactor binding
I6K89_RS15500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6K89_RS15505	COG3339	Conserved Protein
I6K89_RS15515	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6K89_RS15530	COG1113	amino acid transport
I6K89_RS15540	COG0019	diaminopimelate decarboxylase activity
I6K89_RS15550	COG1280	lysine exporter protein (LysE YggA)
I6K89_RS15555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K89_RS15585	COG0463	Glycosyl transferase, family 2
I6K89_RS15605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS15640	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K89_RS15645	COG1136	(ABC) transporter
I6K89_RS15650	COG0658	competence protein
I6K89_RS15650	COG2333	competence protein COMEC
I6K89_RS15660	COG0616	signal peptide processing
I6K89_RS15660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6K89_RS15665	COG0596	Alpha beta hydrolase
I6K89_RS15670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K89_RS15680	COG0628	permease
I6K89_RS15715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K89_RS15735	COG0823	Involved in the tonB-independent uptake of proteins
I6K89_RS15755	COG0824	Thioesterase
I6K89_RS15760	COG1473	amidohydrolase
I6K89_RS15780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K89_RS15780	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K89_RS15785	COG2814	Major facilitator Superfamily
I6K89_RS15795	COG1024	Enoyl-CoA hydratase
I6K89_RS15800	COG1051	belongs to the nudix hydrolase family
I6K89_RS15800	COG1056	cytidyltransferase-related domain
I6K89_RS15810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K89_RS15825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6K89_RS15840	COG4625	pathogenesis
I6K89_RS15845	COG0583	DNA-binding transcription factor activity
I6K89_RS15850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K89_RS15855	COG4208	sulfate ABC transporter
I6K89_RS15860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K89_RS15870	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K89_RS15875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K89_RS15880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K89_RS15900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K89_RS15915	COG0681	Belongs to the peptidase S26 family
I6K89_RS15930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6K89_RS15940	COG1381	Involved in DNA repair and RecF pathway recombination
I6K89_RS15945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K89_RS15955	COG4221	oxidoreductase activity
I6K89_RS15985	COG0436	Aminotransferase
I6K89_RS16005	COG0556	nucleotide-excision repair
I6K89_RS16200	COG5410	chromosome segregation
I6K89_RS16390	COG2070	2-Nitropropane dioxygenase
I6K89_RS16420	COG1215	transferase activity, transferring glycosyl groups
I6K89_RS16435	COG0415	Belongs to the DNA photolyase family
I6K89_RS16445	COG1252	NADH dehydrogenase
I6K89_RS16450	COG1686	Belongs to the peptidase S11 family
I6K89_RS16465	COG1187	pseudouridine synthase activity
I6K89_RS16490	COG0477	Major facilitator Superfamily
I6K89_RS16495	COG0583	DNA-binding transcription factor activity
I6K89_RS16500	COG1823	symporter activity
I6K89_RS16510	COG0612	Peptidase, M16
I6K89_RS16535	COG0352	thiamine-phosphate diphosphorylase activity
I6K89_RS16570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K89_RS16585	COG1309	transcriptional regulator
I6K89_RS16595	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K89_RS16600	COG0076	glutamate decarboxylase activity
I6K89_RS16610	COG1522	sequence-specific DNA binding
I6K89_RS16615	COG3961	Belongs to the TPP enzyme family
I6K89_RS16620	COG1113	amino acid transport
I6K89_RS16625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K89_RS16630	COG0573	inorganic phosphate transmembrane transporter activity
I6K89_RS16640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K89_RS16645	COG0616	signal peptide processing
I6K89_RS16680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K89_RS16685	COG1686	Belongs to the peptidase S11 family
I6K89_RS16710	COG0583	DNA-binding transcription factor activity
I6K89_RS16715	COG1067	ATP-dependent peptidase activity
I6K89_RS16760	COG1966	Carbon starvation protein
I6K89_RS16765	COG2879	small protein
I6K89_RS16795	COG2508	Transcriptional regulator
I6K89_RS16795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6K89_RS16815	COG1113	amino acid transport
I6K89_RS16820	COG0583	DNA-binding transcription factor activity
I6K89_RS16825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K89_RS16830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K89_RS16840	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS16845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K89_RS16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K89_RS16850	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6K89_RS16885	COG2814	Major facilitator Superfamily
I6K89_RS16890	COG4948	Mandelate Racemase Muconate Lactonizing
I6K89_RS16900	COG1309	transcriptional regulator
I6K89_RS16920	COG1741	Belongs to the pirin family
I6K89_RS16930	COG2964	Protein conserved in bacteria
I6K89_RS16945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K89_RS16950	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K89_RS16955	COG4605	iron ion homeostasis
I6K89_RS16960	COG4604	ABC transporter, ATP-binding protein
I6K89_RS16965	COG4607	ABC-type enterochelin transport system periplasmic component
I6K89_RS16970	COG4774	siderophore transport
I6K89_RS16980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K89_RS16985	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K89_RS16990	COG3433	isochorismatase activity
I6K89_RS16990	COG1535	isochorismatase
I6K89_RS17005	COG1132	(ABC) transporter
I6K89_RS17010	COG1132	(ABC) transporter
I6K89_RS17025	COG1169	isochorismate synthase
I6K89_RS17040	COG3739	integral membrane protein
I6K89_RS17070	COG0302	gtp cyclohydrolase
I6K89_RS17080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K89_RS17110	COG0308	aminopeptidase N
I6K89_RS17115	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K89_RS17130	COG0174	glutamine synthetase
I6K89_RS17140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6K89_RS17175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K89_RS17180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K89_RS17185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K89_RS17205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K89_RS17210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K89_RS17215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K89_RS17230	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS17235	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K89_RS17240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K89_RS17250	COG2223	nitrite transmembrane transporter activity
I6K89_RS17260	COG0024	Methionine aminopeptidase
I6K89_RS17265	COG0052	Belongs to the universal ribosomal protein uS2 family
I6K89_RS17280	COG2207	Transcriptional regulator
I6K89_RS17305	COG2951	lytic endotransglycosylase activity
I6K89_RS17310	COG0772	Belongs to the SEDS family
I6K89_RS17325	COG0842	Transport permease protein
I6K89_RS17330	COG1131	(ABC) transporter
I6K89_RS17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K89_RS17390	COG4215	(ABC) transporter
I6K89_RS17395	COG4160	amino acid transport
I6K89_RS17400	COG4598	ABC transporter
I6K89_RS17410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K89_RS17415	COG0826	peptidase U32
I6K89_RS17420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K89_RS17435	COG1720	tRNA m6t6A37 methyltransferase activity
I6K89_RS17445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K89_RS17460	COG0642	Histidine kinase
I6K89_RS17470	COG0494	nUDIX hydrolase
I6K89_RS17480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K89_RS17485	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6K89_RS17490	COG3139	Protein of unknown function (DUF1315)
I6K89_RS17495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K89_RS17500	COG1301	dicarboxylic acid transport
I6K89_RS17505	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS17510	COG2819	hydrolase of the alpha beta superfamily
I6K89_RS17520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6K89_RS17530	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K89_RS17535	COG1234	tRNA 3'-trailer cleavage
I6K89_RS17565	COG2363	Small membrane protein
I6K89_RS17585	COG0513	Belongs to the DEAD box helicase family
I6K89_RS17595	COG0778	Nitroreductase
I6K89_RS17625	COG1286	toxin biosynthetic process
I6K89_RS17650	COG4783	chaperone-mediated protein folding
I6K89_RS17655	COG1610	YqeY-like protein
I6K89_RS17755	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K89_RS17780	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6K89_RS17785	COG0786	glutamate:sodium symporter activity
I6K89_RS17795	COG2186	Transcriptional regulator
I6K89_RS17845	COG0477	Major facilitator Superfamily
I6K89_RS17870	COG2985	domain, Protein
I6K89_RS17880	COG2995	paraquat-inducible protein a
I6K89_RS17885	COG3008	intermembrane lipid transfer
I6K89_RS17885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K89_RS17895	COG1794	racemase activity, acting on amino acids and derivatives
I6K89_RS17965	COG0590	tRNA wobble adenosine to inosine editing
I6K89_RS17970	COG2807	transmembrane transport
I6K89_RS17985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K89_RS18000	COG0789	Transcriptional regulator
I6K89_RS18010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K89_RS18030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K89_RS18040	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K89_RS18055	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS18060	COG0531	amino acid
I6K89_RS18065	COG1760	l-serine dehydratase
I6K89_RS18070	COG2030	dehydratase
I6K89_RS18070	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS18075	COG3396	Phenylacetate-CoA oxygenase
I6K89_RS18080	COG3460	Phenylacetate-CoA oxygenase
I6K89_RS18085	COG3396	Phenylacetate-CoA oxygenase
I6K89_RS18090	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K89_RS18095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K89_RS18100	COG1024	Enoyl-CoA hydratase
I6K89_RS18105	COG1024	Enoyl-CoA hydratase
I6K89_RS18110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K89_RS18115	COG0183	Belongs to the thiolase family
I6K89_RS18120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K89_RS18125	COG3327	negative regulation of DNA-templated transcription, initiation
I6K89_RS18135	COG2050	protein possibly involved in aromatic compounds catabolism
I6K89_RS18170	COG0753	catalase activity
I6K89_RS18175	COG3038	cytochrome b561
I6K89_RS18195	COG2267	carboxylic ester hydrolase activity
I6K89_RS18200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K89_RS18205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K89_RS18210	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS18220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K89_RS18230	COG1012	belongs to the aldehyde dehydrogenase family
I6K89_RS18235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K89_RS18240	COG0583	DNA-binding transcription factor activity
I6K89_RS18255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K89_RS18265	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K89_RS18270	COG3842	ATPase activity
I6K89_RS18285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K89_RS18290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K89_RS18295	COG2814	Major facilitator Superfamily
I6K89_RS18300	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS18315	COG1024	Enoyl-CoA hydratase
I6K89_RS18325	COG2814	Major facilitator Superfamily
I6K89_RS18335	COG0183	Belongs to the thiolase family
I6K89_RS18340	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K89_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
I6K89_RS18350	COG1024	Enoyl-CoA hydratase
I6K89_RS18355	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS18360	COG2814	Major facilitator Superfamily
I6K89_RS18365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K89_RS18370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K89_RS18380	COG2814	Major facilitator Superfamily
I6K89_RS18390	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS18405	COG0583	DNA-binding transcription factor activity
I6K89_RS18415	COG4770	biotin carboxylase activity
I6K89_RS18420	COG1024	Enoyl-CoA hydratase
I6K89_RS18425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K89_RS18430	COG1960	acyl-CoA dehydrogenase activity
I6K89_RS18435	COG1309	transcriptional regulator
I6K89_RS18440	COG0318	PFAM AMP-dependent synthetase and ligase
I6K89_RS18460	COG0583	DNA-binding transcription factor activity