locus-tag	class	description
I6K90_RS00290	COG0739	heme binding
I6K90_RS00335	COG2194	sulfuric ester hydrolase activity
I6K90_RS00375	COG0006	proline dipeptidase activity
I6K90_RS00380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K90_RS00385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K90_RS00405	COG1279	arginine transmembrane transporter activity
I6K90_RS00410	COG0583	DNA-binding transcription factor activity
I6K90_RS00450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K90_RS00455	COG0741	lytic transglycosylase activity
I6K90_RS00455	COG0741	lytic transglycosylase activity
I6K90_RS00455	COG1388	LysM domain
I6K90_RS00455	COG1388	LysM domain
I6K90_RS00465	COG4174	ABC transporter (Permease)
I6K90_RS00470	COG4239	(ABC) transporter, permease
I6K90_RS00475	COG4172	Belongs to the ABC transporter superfamily
I6K90_RS00495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K90_RS00505	COG5001	Diguanylate cyclase
I6K90_RS00505	COG4251	negative regulation of phosphorylation
I6K90_RS00505	COG3706	GGDEF domain
I6K90_RS00505	COG2203	Gaf domain
I6K90_RS00515	COG1902	pentaerythritol trinitrate reductase activity
I6K90_RS00515	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K90_RS00530	COG4269	membrane
I6K90_RS00590	COG0527	aspartate kinase activity
I6K90_RS00600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K90_RS00610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6K90_RS00625	COG0667	Aldo Keto reductase
I6K90_RS00640	COG1765	OsmC-like protein
I6K90_RS00655	COG0542	response to heat
I6K90_RS00690	COG2885	chlorophyll binding
I6K90_RS00700	COG0625	glutathione transferase activity
I6K90_RS00705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6K90_RS00725	COG3634	alkyl hydroperoxide reductase activity
I6K90_RS00735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6K90_RS00745	COG0450	alkyl hydroperoxide reductase
I6K90_RS00750	COG1643	Atp-dependent helicase
I6K90_RS00765	COG2814	Major facilitator Superfamily
I6K90_RS00770	COG3135	benzoate transporter
I6K90_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS00780	COG0543	2 iron, 2 sulfur cluster binding
I6K90_RS00780	COG0633	Ferredoxin
I6K90_RS00785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K90_RS00790	COG4638	Rieske (2fe-2S)
I6K90_RS00795	COG0583	DNA-binding transcription factor activity
I6K90_RS00845	COG1570	exodeoxyribonuclease VII activity
I6K90_RS00880	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS00885	COG1278	Cold shock
I6K90_RS00920	COG2814	Major facilitator Superfamily
I6K90_RS00955	COG0517	IMP dehydrogenase activity
I6K90_RS00955	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K90_RS00960	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K90_RS00970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K90_RS00975	COG1137	ATPase activity
I6K90_RS00985	COG1538	Outer membrane efflux protein
I6K90_RS01015	COG4122	O-methyltransferase activity
I6K90_RS01025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K90_RS01040	COG1522	sequence-specific DNA binding
I6K90_RS01045	COG5006	permease, DMT superfamily
I6K90_RS01055	COG1560	Kdo2-lipid A biosynthetic process
I6K90_RS01065	COG2814	Major facilitator Superfamily
I6K90_RS01090	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K90_RS01140	COG0583	DNA-binding transcription factor activity
I6K90_RS01145	COG1914	H( )-stimulated, divalent metal cation uptake system
I6K90_RS01165	COG4770	biotin carboxylase activity
I6K90_RS01170	COG0038	chloride channel
I6K90_RS01190	COG1309	transcriptional regulator
I6K90_RS01200	COG1063	alcohol dehydrogenase
I6K90_RS01215	COG0439	Biotin carboxylase
I6K90_RS01220	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K90_RS01240	COG0864	Transcriptional regulator
I6K90_RS01250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K90_RS01255	COG1116	anion transmembrane transporter activity
I6K90_RS01370	COG0590	tRNA wobble adenosine to inosine editing
I6K90_RS01375	COG2807	transmembrane transport
I6K90_RS01390	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K90_RS01400	COG0789	Transcriptional regulator
I6K90_RS01410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K90_RS01430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K90_RS01440	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K90_RS01465	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS01470	COG0531	amino acid
I6K90_RS01475	COG1760	l-serine dehydratase
I6K90_RS01480	COG2030	dehydratase
I6K90_RS01480	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS01485	COG3396	Phenylacetate-CoA oxygenase
I6K90_RS01490	COG3460	Phenylacetate-CoA oxygenase
I6K90_RS01495	COG3396	Phenylacetate-CoA oxygenase
I6K90_RS01500	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K90_RS01505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K90_RS01510	COG1024	Enoyl-CoA hydratase
I6K90_RS01515	COG1024	Enoyl-CoA hydratase
I6K90_RS01520	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K90_RS01525	COG0183	Belongs to the thiolase family
I6K90_RS01530	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6K90_RS01535	COG3327	negative regulation of DNA-templated transcription, initiation
I6K90_RS01545	COG2050	protein possibly involved in aromatic compounds catabolism
I6K90_RS01580	COG0753	catalase activity
I6K90_RS01585	COG3038	cytochrome b561
I6K90_RS01605	COG2267	carboxylic ester hydrolase activity
I6K90_RS01610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K90_RS01615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K90_RS01620	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS01630	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K90_RS01640	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS01645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K90_RS01650	COG0583	DNA-binding transcription factor activity
I6K90_RS01660	COG1414	Transcriptional regulator
I6K90_RS01665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K90_RS01675	COG1840	ABC-type Fe3 transport system, periplasmic component
I6K90_RS01680	COG3842	ATPase activity
I6K90_RS01695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6K90_RS01700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K90_RS01705	COG2814	Major facilitator Superfamily
I6K90_RS01710	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS01725	COG1024	Enoyl-CoA hydratase
I6K90_RS01735	COG2814	Major facilitator Superfamily
I6K90_RS01745	COG0183	Belongs to the thiolase family
I6K90_RS01750	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K90_RS01755	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS01760	COG1024	Enoyl-CoA hydratase
I6K90_RS01765	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS01770	COG2814	Major facilitator Superfamily
I6K90_RS01775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K90_RS01780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K90_RS01790	COG2814	Major facilitator Superfamily
I6K90_RS01800	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS01815	COG0583	DNA-binding transcription factor activity
I6K90_RS01825	COG4770	biotin carboxylase activity
I6K90_RS01830	COG1024	Enoyl-CoA hydratase
I6K90_RS01835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K90_RS01840	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS01845	COG1309	transcriptional regulator
I6K90_RS01850	COG0318	PFAM AMP-dependent synthetase and ligase
I6K90_RS01870	COG0583	DNA-binding transcription factor activity
I6K90_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS01940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K90_RS01960	COG0784	Response regulator, receiver
I6K90_RS01960	COG2205	protein histidine kinase activity
I6K90_RS01980	COG0765	amino acid transport
I6K90_RS01985	COG0765	amino acid transport
I6K90_RS01990	COG1126	abc transporter atp-binding protein
I6K90_RS02000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K90_RS02015	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS02025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K90_RS02030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K90_RS02035	COG1045	serine acetyltransferase
I6K90_RS02050	COG0583	DNA-binding transcription factor activity
I6K90_RS02055	COG0625	glutathione transferase activity
I6K90_RS02060	COG0625	glutathione transferase activity
I6K90_RS02065	COG0583	DNA-binding transcription factor activity
I6K90_RS02075	COG1346	cytolysis
I6K90_RS02095	COG2814	Major facilitator Superfamily
I6K90_RS02105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6K90_RS02110	COG3052	prosthetic group binding
I6K90_RS02130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K90_RS02150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K90_RS02160	COG1294	oxidase, subunit
I6K90_RS02165	COG1271	oxidase subunit
I6K90_RS02185	COG0477	Major facilitator Superfamily
I6K90_RS02205	COG4521	taurine ABC transporter
I6K90_RS02210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6K90_RS02215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K90_RS02220	COG2175	clavaminate synthase activity
I6K90_RS02230	COG1953	Uracil, thiamine, allantoin
I6K90_RS02240	COG0583	DNA-binding transcription factor activity
I6K90_RS02250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6K90_RS02265	COG0640	Transcriptional regulator
I6K90_RS02270	COG0798	PFAM Bile acid sodium symporter
I6K90_RS02275	COG0583	DNA-binding transcription factor activity
I6K90_RS02290	COG3634	alkyl hydroperoxide reductase activity
I6K90_RS02330	COG0436	Aminotransferase
I6K90_RS02340	COG0386	Belongs to the glutathione peroxidase family
I6K90_RS02380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K90_RS02405	COG0012	GTP binding
I6K90_RS02410	COG2011	ABC-type metal ion transport system permease component
I6K90_RS02415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K90_RS02425	COG1464	Belongs to the NlpA lipoprotein family
I6K90_RS02455	COG0765	amino acid transport
I6K90_RS02460	COG0765	amino acid transport
I6K90_RS02465	COG1126	abc transporter atp-binding protein
I6K90_RS02475	COG1522	sequence-specific DNA binding
I6K90_RS02540	COG0305	Participates in initiation and elongation during chromosome replication
I6K90_RS02605	COG4695	Portal protein
I6K90_RS02665	COG0739	heme binding
I6K90_RS02665	COG0741	lytic transglycosylase activity
I6K90_RS02665	COG1196	nuclear chromosome segregation
I6K90_RS02735	COG1309	transcriptional regulator
I6K90_RS02755	COG0583	DNA-binding transcription factor activity
I6K90_RS02765	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K90_RS02775	COG0697	spore germination
I6K90_RS02800	COG3121	Chaperone
I6K90_RS02805	COG3539	Fimbrial protein
I6K90_RS02830	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K90_RS02830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K90_RS02875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K90_RS02885	COG2353	YceI-like domain
I6K90_RS02895	COG3698	Phosphodiester glycosidase
I6K90_RS02910	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6K90_RS02915	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K90_RS02915	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K90_RS02915	COG0506	proline dehydrogenase activity
I6K90_RS02925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K90_RS02930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K90_RS02950	COG1132	(ABC) transporter
I6K90_RS02955	COG3122	Protein conserved in bacteria
I6K90_RS02960	COG3619	membrane
I6K90_RS02970	COG0640	Transcriptional regulator
I6K90_RS02980	COG2850	peptidyl-arginine hydroxylation
I6K90_RS02985	COG0424	maF-like protein
I6K90_RS03005	COG0191	fructose-bisphosphate aldolase activity
I6K90_RS03010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K90_RS03025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6K90_RS03035	COG1192	Involved in chromosome partitioning
I6K90_RS03040	COG1475	DNA binding
I6K90_RS03045	COG0811	peptide transport
I6K90_RS03055	COG1132	(ABC) transporter
I6K90_RS03060	COG1663	tetraacyldisaccharide 4'-kinase activity
I6K90_RS03080	COG0084	hydrolase, TatD family'
I6K90_RS03145	COG0776	regulation of translation
I6K90_RS03175	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K90_RS03180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K90_RS03230	COG0339	signal peptide processing
I6K90_RS03240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K90_RS03275	COG0702	epimerase
I6K90_RS03280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K90_RS03310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K90_RS03340	COG0316	Belongs to the HesB IscA family
I6K90_RS03345	COG0822	iron-sulfur transferase activity
I6K90_RS03370	COG0776	regulation of translation
I6K90_RS03375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K90_RS03380	COG2207	Transcriptional regulator
I6K90_RS03385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K90_RS03390	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS03395	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS03410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K90_RS03425	COG2814	Major facilitator Superfamily
I6K90_RS03430	COG4264	IucA IucC family
I6K90_RS03435	COG4264	IucA IucC family
I6K90_RS03475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K90_RS03490	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6K90_RS03510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K90_RS03515	COG0730	response to heat
I6K90_RS03535	COG4773	Receptor
I6K90_RS03540	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K90_RS03555	COG1131	(ABC) transporter
I6K90_RS03560	COG0842	Transport permease protein
I6K90_RS03565	COG0842	Transport permease protein
I6K90_RS03620	COG2226	methyltransferase
I6K90_RS03645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6K90_RS03680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K90_RS03690	COG0133	tryptophan synthase activity
I6K90_RS03705	COG3706	GGDEF domain
I6K90_RS03720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K90_RS03725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K90_RS03730	COG0022	dehydrogenase e1 component
I6K90_RS03735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K90_RS03740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K90_RS03750	COG1063	alcohol dehydrogenase
I6K90_RS03755	COG3781	membrane
I6K90_RS03765	COG3453	Protein conserved in bacteria
I6K90_RS03765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K90_RS03775	COG0730	response to heat
I6K90_RS03790	COG2207	Transcriptional regulator
I6K90_RS03790	COG3708	Transcriptional regulator
I6K90_RS03795	COG1733	regulation of RNA biosynthetic process
I6K90_RS03800	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6K90_RS03810	COG2188	Transcriptional regulator
I6K90_RS03825	COG4521	taurine ABC transporter
I6K90_RS03830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K90_RS03850	COG0477	Major facilitator Superfamily
I6K90_RS03860	COG1027	Aspartate ammonia-lyase
I6K90_RS03875	COG0583	DNA-binding transcription factor activity
I6K90_RS03880	COG0583	DNA-binding transcription factor activity
I6K90_RS03885	COG0183	Belongs to the thiolase family
I6K90_RS03905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K90_RS03915	COG0583	DNA-binding transcription factor activity
I6K90_RS03925	COG2610	gluconate transmembrane transporter activity
I6K90_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS03940	COG2207	Transcriptional regulator
I6K90_RS03955	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS03980	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K90_RS03980	COG0543	2 iron, 2 sulfur cluster binding
I6K90_RS03985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6K90_RS03990	COG4638	Rieske (2fe-2S)
I6K90_RS04000	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K90_RS04005	COG4149	molybdate abc transporter
I6K90_RS04010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6K90_RS04015	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS04020	COG1535	isochorismatase
I6K90_RS04020	COG3433	isochorismatase activity
I6K90_RS04080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K90_RS04095	COG0753	catalase activity
I6K90_RS04105	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6K90_RS04150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K90_RS04170	COG2072	flavoprotein involved in K transport
I6K90_RS04180	COG1538	Outer membrane efflux protein
I6K90_RS04185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K90_RS04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS04195	COG0745	RESPONSE REGULATOR receiver
I6K90_RS04200	COG2205	protein histidine kinase activity
I6K90_RS04210	COG2207	Transcriptional regulator
I6K90_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS04275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I6K90_RS04390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K90_RS04410	COG1120	ATPase activity
I6K90_RS04415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K90_RS04425	COG1064	alcohol dehydrogenase
I6K90_RS04440	COG2207	Transcriptional regulator
I6K90_RS04445	COG2084	Dehydrogenase
I6K90_RS04455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K90_RS04460	COG0583	DNA-binding transcription factor activity
I6K90_RS04480	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS04495	COG1566	PFAM secretion protein HlyD family protein
I6K90_RS04515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6K90_RS04545	COG0583	DNA-binding transcription factor activity
I6K90_RS04560	COG2188	Transcriptional regulator
I6K90_RS04590	COG3210	domain, Protein
I6K90_RS04595	COG2831	hemolysin activation secretion protein
I6K90_RS04605	COG1473	amidohydrolase
I6K90_RS04615	COG0475	glutathione-regulated potassium exporter activity
I6K90_RS04615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K90_RS04625	COG0583	DNA-binding transcription factor activity
I6K90_RS04630	COG1335	isochorismatase
I6K90_RS04640	COG1309	transcriptional regulator
I6K90_RS04670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K90_RS04680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K90_RS04680	COG1902	pentaerythritol trinitrate reductase activity
I6K90_RS04685	COG1846	Transcriptional regulator
I6K90_RS04705	COG0753	catalase activity
I6K90_RS04720	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS04735	COG3162	membrane
I6K90_RS04745	COG3829	transcription factor binding
I6K90_RS04750	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS04755	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS04775	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS04795	COG2186	Transcriptional regulator
I6K90_RS04805	COG0583	DNA-binding transcription factor activity
I6K90_RS04810	COG4948	Mandelate Racemase Muconate Lactonizing
I6K90_RS04815	COG4829	muconolactone delta-isomerase
I6K90_RS04825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K90_RS04830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K90_RS04835	COG0183	Belongs to the thiolase family
I6K90_RS04840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K90_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS04860	COG3733	amine oxidase
I6K90_RS04870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K90_RS04880	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS04890	COG4638	Rieske (2fe-2S)
I6K90_RS04910	COG0154	amidase activity
I6K90_RS04920	COG2814	Major facilitator Superfamily
I6K90_RS04945	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS04950	COG0583	DNA-binding transcription factor activity
I6K90_RS04955	COG1414	Transcriptional regulator
I6K90_RS04970	COG2391	methyltransferase activity
I6K90_RS04980	COG4993	Dehydrogenase
I6K90_RS04985	COG3659	wide pore channel activity
I6K90_RS04990	COG3420	alginic acid biosynthetic process
I6K90_RS04995	COG0710	3-dehydroquinate dehydratase activity
I6K90_RS05000	COG3485	protocatechuate 3,4-dioxygenase
I6K90_RS05005	COG3485	protocatechuate 3,4-dioxygenase
I6K90_RS05010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K90_RS05015	COG2271	Major facilitator Superfamily
I6K90_RS05020	COG0596	Alpha beta hydrolase
I6K90_RS05025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K90_RS05030	COG0183	Belongs to the thiolase family
I6K90_RS05035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K90_RS05040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K90_RS05050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6K90_RS05055	COG2323	membrane
I6K90_RS05100	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K90_RS05100	COG1902	pentaerythritol trinitrate reductase activity
I6K90_RS05125	COG0542	response to heat
I6K90_RS05130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6K90_RS05160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K90_RS05165	COG0569	domain protein
I6K90_RS05170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K90_RS05185	COG4774	siderophore transport
I6K90_RS05190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K90_RS05200	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K90_RS05215	COG1294	oxidase, subunit
I6K90_RS05220	COG4890	Cyd operon protein YbgT
I6K90_RS05235	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6K90_RS05245	COG0552	protein localization to endoplasmic reticulum
I6K90_RS05270	COG0516	GMP reductase activity
I6K90_RS05270	COG0517	IMP dehydrogenase activity
I6K90_RS05275	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K90_RS05280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K90_RS05290	COG0583	DNA-binding transcription factor activity
I6K90_RS05295	COG0024	Methionine aminopeptidase
I6K90_RS05325	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K90_RS05325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K90_RS05330	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K90_RS05335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K90_RS05335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K90_RS05335	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K90_RS05355	COG3300	MHYT domain
I6K90_RS05355	COG5001	Diguanylate cyclase
I6K90_RS05370	COG2135	peptidase activity
I6K90_RS05375	COG0659	secondary active sulfate transmembrane transporter activity
I6K90_RS05390	COG1113	amino acid transport
I6K90_RS05400	COG1522	sequence-specific DNA binding
I6K90_RS05425	COG1011	Hydrolase
I6K90_RS05430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K90_RS05440	COG2137	regulation of response to DNA damage stimulus
I6K90_RS05455	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K90_RS05490	COG0575	Belongs to the CDS family
I6K90_RS05495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K90_RS05515	COG3852	Histidine kinase
I6K90_RS05520	COG2204	response regulator
I6K90_RS05575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K90_RS05580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K90_RS05600	COG0697	spore germination
I6K90_RS05605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K90_RS05615	COG0303	'Molybdopterin
I6K90_RS05620	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K90_RS05620	COG0315	cyclic pyranopterin monophosphate synthase activity
I6K90_RS05635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6K90_RS05640	COG0243	molybdopterin cofactor binding
I6K90_RS05650	COG0243	molybdopterin cofactor binding
I6K90_RS05655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K90_RS05660	COG2146	nitrite reductase [NAD(P)H] activity
I6K90_RS05660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K90_RS05670	COG0745	RESPONSE REGULATOR receiver
I6K90_RS05675	COG1116	anion transmembrane transporter activity
I6K90_RS05675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K90_RS05695	COG0511	ligase activity, forming carbon-carbon bonds
I6K90_RS05710	COG2814	Major facilitator Superfamily
I6K90_RS06040	COG0069	glutamate synthase activity
I6K90_RS06060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K90_RS06070	COG1454	alcohol dehydrogenase
I6K90_RS06075	COG0824	Thioesterase
I6K90_RS06085	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K90_RS06100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K90_RS06105	COG2030	dehydratase
I6K90_RS06115	COG0183	Belongs to the thiolase family
I6K90_RS06125	COG0583	DNA-binding transcription factor activity
I6K90_RS06130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K90_RS06140	COG1522	sequence-specific DNA binding
I6K90_RS06145	COG3135	benzoate transporter
I6K90_RS06155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K90_RS06180	COG0589	response to stress
I6K90_RS06185	COG0488	(ABC) transporter
I6K90_RS06205	COG4773	Receptor
I6K90_RS06235	COG0668	transmembrane transport
I6K90_RS06245	COG1309	transcriptional regulator
I6K90_RS06260	COG1605	Chorismate mutase
I6K90_RS06270	COG4221	oxidoreductase activity
I6K90_RS06280	COG0308	aminopeptidase N
I6K90_RS06300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K90_RS06310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K90_RS06315	COG1454	alcohol dehydrogenase
I6K90_RS06335	COG0531	amino acid
I6K90_RS06340	COG4303	Ethanolamine ammonia lyase large subunit
I6K90_RS06345	COG4302	ethanolamine ammonia-lyase activity
I6K90_RS06350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K90_RS06350	COG0519	Catalyzes the synthesis of GMP from XMP
I6K90_RS06355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K90_RS06365	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6K90_RS06380	COG0697	spore germination
I6K90_RS06385	COG1923	regulation of RNA biosynthetic process
I6K90_RS06395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6K90_RS06400	COG0802	atpase or kinase
I6K90_RS06420	COG1187	pseudouridine synthase activity
I6K90_RS06435	COG0583	DNA-binding transcription factor activity
I6K90_RS06450	COG2814	Major facilitator Superfamily
I6K90_RS06455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K90_RS06480	COG0729	surface antigen
I6K90_RS06500	COG0174	glutamine synthetase
I6K90_RS06505	COG0745	RESPONSE REGULATOR receiver
I6K90_RS06510	COG2205	protein histidine kinase activity
I6K90_RS06520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6K90_RS06525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6K90_RS06550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K90_RS06555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K90_RS06560	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS06575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K90_RS06580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K90_RS06600	COG0583	DNA-binding transcription factor activity
I6K90_RS06615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K90_RS06625	COG3658	cytochrome
I6K90_RS06630	COG1215	transferase activity, transferring glycosyl groups
I6K90_RS06635	COG0726	polysaccharide deacetylase
I6K90_RS06635	COG1649	PFAM Uncharacterised BCR, COG1649
I6K90_RS06660	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K90_RS06665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K90_RS06675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K90_RS06700	COG0305	Participates in initiation and elongation during chromosome replication
I6K90_RS06705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K90_RS06715	COG1305	Transglutaminase-like
I6K90_RS06725	COG2308	Evidence 4 Homologs of previously reported genes of
I6K90_RS06755	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6K90_RS06760	COG0138	bifunctional purine biosynthesis protein purh
I6K90_RS06765	COG0151	Belongs to the GarS family
I6K90_RS06770	COG1464	Belongs to the NlpA lipoprotein family
I6K90_RS06775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K90_RS06780	COG2011	ABC-type metal ion transport system permease component
I6K90_RS06785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K90_RS06795	COG1301	dicarboxylic acid transport
I6K90_RS06825	COG1794	racemase activity, acting on amino acids and derivatives
I6K90_RS06835	COG3008	intermembrane lipid transfer
I6K90_RS06835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K90_RS06840	COG2995	paraquat-inducible protein a
I6K90_RS06850	COG2985	domain, Protein
I6K90_RS06875	COG0477	Major facilitator Superfamily
I6K90_RS06925	COG2186	Transcriptional regulator
I6K90_RS06935	COG0786	glutamate:sodium symporter activity
I6K90_RS06940	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6K90_RS06965	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K90_RS07065	COG1610	YqeY-like protein
I6K90_RS07070	COG4783	chaperone-mediated protein folding
I6K90_RS07095	COG1286	toxin biosynthetic process
I6K90_RS07125	COG0778	Nitroreductase
I6K90_RS07135	COG0513	Belongs to the DEAD box helicase family
I6K90_RS07155	COG2363	Small membrane protein
I6K90_RS07185	COG1234	tRNA 3'-trailer cleavage
I6K90_RS07190	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K90_RS07200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6K90_RS07210	COG2819	hydrolase of the alpha beta superfamily
I6K90_RS07215	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS07220	COG1301	dicarboxylic acid transport
I6K90_RS07225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K90_RS07230	COG3139	Protein of unknown function (DUF1315)
I6K90_RS07235	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6K90_RS07240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K90_RS07250	COG0494	nUDIX hydrolase
I6K90_RS07260	COG0642	Histidine kinase
I6K90_RS07275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K90_RS07285	COG1720	tRNA m6t6A37 methyltransferase activity
I6K90_RS07300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K90_RS07305	COG0826	peptidase U32
I6K90_RS07310	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K90_RS07320	COG4598	ABC transporter
I6K90_RS07325	COG4160	amino acid transport
I6K90_RS07330	COG4215	(ABC) transporter
I6K90_RS07345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS07390	COG1131	(ABC) transporter
I6K90_RS07395	COG0842	Transport permease protein
I6K90_RS07410	COG0772	Belongs to the SEDS family
I6K90_RS07415	COG2951	lytic endotransglycosylase activity
I6K90_RS07450	COG2207	Transcriptional regulator
I6K90_RS07465	COG0052	Belongs to the universal ribosomal protein uS2 family
I6K90_RS07470	COG0024	Methionine aminopeptidase
I6K90_RS07480	COG2223	nitrite transmembrane transporter activity
I6K90_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K90_RS07495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6K90_RS07500	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS07515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6K90_RS07520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K90_RS07525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K90_RS07545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K90_RS07550	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K90_RS07555	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K90_RS07590	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6K90_RS07600	COG0174	glutamine synthetase
I6K90_RS07615	COG0582	viral genome integration into host DNA
I6K90_RS07710	COG1598	PFAM Uncharacterised protein family UPF0150
I6K90_RS07810	COG5410	chromosome segregation
I6K90_RS07990	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K90_RS07995	COG0308	aminopeptidase N
I6K90_RS08025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K90_RS08035	COG0302	gtp cyclohydrolase
I6K90_RS08060	COG3739	integral membrane protein
I6K90_RS08075	COG1169	isochorismate synthase
I6K90_RS08085	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6K90_RS08090	COG1132	(ABC) transporter
I6K90_RS08095	COG1132	(ABC) transporter
I6K90_RS08110	COG1535	isochorismatase
I6K90_RS08110	COG3433	isochorismatase activity
I6K90_RS08115	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K90_RS08120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K90_RS08130	COG4774	siderophore transport
I6K90_RS08135	COG4607	ABC-type enterochelin transport system periplasmic component
I6K90_RS08140	COG4604	ABC transporter, ATP-binding protein
I6K90_RS08145	COG4605	iron ion homeostasis
I6K90_RS08150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K90_RS08155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K90_RS08170	COG2964	Protein conserved in bacteria
I6K90_RS08180	COG1741	Belongs to the pirin family
I6K90_RS08210	COG4948	Mandelate Racemase Muconate Lactonizing
I6K90_RS08215	COG2814	Major facilitator Superfamily
I6K90_RS08250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K90_RS08250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
I6K90_RS08255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K90_RS08280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K90_RS08285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K90_RS08290	COG0583	DNA-binding transcription factor activity
I6K90_RS08295	COG1113	amino acid transport
I6K90_RS08315	COG2508	Transcriptional regulator
I6K90_RS08315	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6K90_RS08345	COG2879	small protein
I6K90_RS08350	COG1966	Carbon starvation protein
I6K90_RS08395	COG1067	ATP-dependent peptidase activity
I6K90_RS08400	COG0583	DNA-binding transcription factor activity
I6K90_RS08425	COG1686	Belongs to the peptidase S11 family
I6K90_RS08430	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K90_RS08465	COG0616	signal peptide processing
I6K90_RS08470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K90_RS08480	COG0573	inorganic phosphate transmembrane transporter activity
I6K90_RS08485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K90_RS08490	COG1113	amino acid transport
I6K90_RS08495	COG3961	Belongs to the TPP enzyme family
I6K90_RS08500	COG1522	sequence-specific DNA binding
I6K90_RS08510	COG0076	glutamate decarboxylase activity
I6K90_RS08515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K90_RS08525	COG1309	transcriptional regulator
I6K90_RS08540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K90_RS08575	COG0352	thiamine-phosphate diphosphorylase activity
I6K90_RS08600	COG0612	Peptidase, M16
I6K90_RS08610	COG1823	symporter activity
I6K90_RS08615	COG0583	DNA-binding transcription factor activity
I6K90_RS08620	COG0477	Major facilitator Superfamily
I6K90_RS08645	COG1187	pseudouridine synthase activity
I6K90_RS08660	COG1686	Belongs to the peptidase S11 family
I6K90_RS08665	COG1252	NADH dehydrogenase
I6K90_RS08675	COG0415	Belongs to the DNA photolyase family
I6K90_RS08690	COG1215	transferase activity, transferring glycosyl groups
I6K90_RS08720	COG2070	2-Nitropropane dioxygenase
I6K90_RS08775	COG0556	nucleotide-excision repair
I6K90_RS08795	COG0436	Aminotransferase
I6K90_RS08825	COG4221	oxidoreductase activity
I6K90_RS08835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K90_RS08840	COG1381	Involved in DNA repair and RecF pathway recombination
I6K90_RS08850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6K90_RS08865	COG0681	Belongs to the peptidase S26 family
I6K90_RS08880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K90_RS08900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K90_RS08905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K90_RS08910	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K90_RS08920	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K90_RS08925	COG4208	sulfate ABC transporter
I6K90_RS08930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K90_RS08935	COG0583	DNA-binding transcription factor activity
I6K90_RS08940	COG4625	pathogenesis
I6K90_RS08955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6K90_RS08970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K90_RS08980	COG1051	belongs to the nudix hydrolase family
I6K90_RS08980	COG1056	cytidyltransferase-related domain
I6K90_RS08985	COG1024	Enoyl-CoA hydratase
I6K90_RS08995	COG2814	Major facilitator Superfamily
I6K90_RS09000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K90_RS09000	COG0047	phosphoribosylformylglycinamidine synthase activity
I6K90_RS09020	COG1473	amidohydrolase
I6K90_RS09025	COG0824	Thioesterase
I6K90_RS09045	COG0823	Involved in the tonB-independent uptake of proteins
I6K90_RS09065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K90_RS09100	COG0628	permease
I6K90_RS09110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K90_RS09115	COG0596	Alpha beta hydrolase
I6K90_RS09120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6K90_RS09120	COG0616	signal peptide processing
I6K90_RS09130	COG0658	competence protein
I6K90_RS09130	COG2333	competence protein COMEC
I6K90_RS09135	COG1136	(ABC) transporter
I6K90_RS09140	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K90_RS09175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS09195	COG0463	Glycosyl transferase, family 2
I6K90_RS09225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K90_RS09230	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS09240	COG0019	diaminopimelate decarboxylase activity
I6K90_RS09250	COG1113	amino acid transport
I6K90_RS09265	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I6K90_RS09275	COG3339	Conserved Protein
I6K90_RS09280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6K90_RS09285	COG0243	molybdopterin cofactor binding
I6K90_RS09290	COG1929	Belongs to the glycerate kinase type-1 family
I6K90_RS09305	COG0778	Nitroreductase
I6K90_RS09330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K90_RS09345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K90_RS09365	COG0741	lytic transglycosylase activity
I6K90_RS09385	COG0584	glycerophosphoryl diester phosphodiesterase
I6K90_RS09390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K90_RS09415	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K90_RS09420	COG1597	lipid kinase activity
I6K90_RS09435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6K90_RS09440	COG0477	Major facilitator Superfamily
I6K90_RS09490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K90_RS09495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K90_RS09520	COG0505	Belongs to the CarA family
I6K90_RS09540	COG0589	response to stress
I6K90_RS09555	COG2843	Capsule synthesis protein
I6K90_RS09600	COG2321	neutral zinc metallopeptidase
I6K90_RS09605	COG2354	Protein conserved in bacteria
I6K90_RS09625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K90_RS09650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K90_RS09655	COG1053	succinate dehydrogenase
I6K90_RS09660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K90_RS09665	COG2009	succinate dehydrogenase
I6K90_RS09705	COG2921	Belongs to the UPF0250 family
I6K90_RS09710	COG0321	lipoyl(octanoyl) transferase activity
I6K90_RS09725	COG0531	amino acid
I6K90_RS09735	COG1733	regulation of RNA biosynthetic process
I6K90_RS09740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K90_RS09745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6K90_RS09745	COG1648	precorrin-2 dehydrogenase activity
I6K90_RS09760	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6K90_RS09790	COG0671	phosphoesterase, PA-phosphatase related
I6K90_RS09795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS09805	COG1538	Outer membrane efflux protein
I6K90_RS09810	COG0393	Putative heavy-metal-binding
I6K90_RS09815	COG0393	Putative heavy-metal-binding
I6K90_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS09835	COG0525	valine-tRNA ligase activity
I6K90_RS09855	COG0583	DNA-binding transcription factor activity
I6K90_RS09860	COG0004	ammonium transporteR
I6K90_RS09870	COG0642	Histidine kinase
I6K90_RS09875	COG0745	RESPONSE REGULATOR receiver
I6K90_RS09880	COG2194	sulfuric ester hydrolase activity
I6K90_RS09900	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K90_RS09915	COG2315	Protein conserved in bacteria
I6K90_RS09920	COG0142	geranyltranstransferase activity
I6K90_RS09925	COG2828	Protein conserved in bacteria
I6K90_RS09930	COG1113	amino acid transport
I6K90_RS09950	COG2207	Transcriptional regulator
I6K90_RS09975	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K90_RS09985	COG0560	Phosphoserine phosphatase
I6K90_RS09995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K90_RS10005	COG1530	ribonuclease E activity
I6K90_RS10010	COG0424	maF-like protein
I6K90_RS10015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K90_RS10020	COG1792	Involved in formation and maintenance of cell shape
I6K90_RS10025	COG1077	Cell shape determining protein MreB Mrl
I6K90_RS10030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K90_RS10040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K90_RS10070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K90_RS10075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K90_RS10080	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K90_RS10085	COG1115	amino acid carrier protein
I6K90_RS10105	COG2814	Major facilitator Superfamily
I6K90_RS10110	COG1289	transmembrane transporter activity
I6K90_RS10120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6K90_RS10160	COG1376	ErfK ybiS ycfS ynhG family protein
I6K90_RS10165	COG2832	Protein of unknown function (DUF454)
I6K90_RS10175	COG5510	response to toxic substance
I6K90_RS10195	COG0840	transmembrane signaling receptor activity
I6K90_RS10235	COG3422	double-strand break repair
I6K90_RS10240	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K90_RS10245	COG3189	MarR family transcriptional regulator
I6K90_RS10255	COG0354	folic acid binding
I6K90_RS10260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K90_RS10275	COG1902	pentaerythritol trinitrate reductase activity
I6K90_RS10280	COG4772	TonB-dependent receptor
I6K90_RS10285	COG2094	Belongs to the DNA glycosylase MPG family
I6K90_RS10310	COG1217	gtp-binding protein TYPA
I6K90_RS10315	COG2233	PERMEase
I6K90_RS10325	COG0833	amino acid
I6K90_RS10330	COG1690	Belongs to the RtcB family
I6K90_RS10340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K90_RS10340	COG2885	chlorophyll binding
I6K90_RS10350	COG0183	Belongs to the thiolase family
I6K90_RS10370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K90_RS10390	COG2207	Transcriptional regulator
I6K90_RS10395	COG0183	Belongs to the thiolase family
I6K90_RS10425	COG1272	protein, Hemolysin III
I6K90_RS10430	COG0477	Major facilitator Superfamily
I6K90_RS10445	COG0450	alkyl hydroperoxide reductase
I6K90_RS10465	COG0285	dihydrofolate synthase activity
I6K90_RS10515	COG2096	Adenosyltransferase
I6K90_RS10535	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6K90_RS10540	COG0745	RESPONSE REGULATOR receiver
I6K90_RS10545	COG2205	protein histidine kinase activity
I6K90_RS10555	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS10560	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS10565	COG0583	DNA-binding transcription factor activity
I6K90_RS10570	COG0625	glutathione transferase activity
I6K90_RS10635	COG0438	transferase activity, transferring glycosyl groups
I6K90_RS10640	COG0463	Glycosyl transferase, family 2
I6K90_RS10645	COG0726	polysaccharide deacetylase
I6K90_RS10665	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6K90_RS10715	COG1862	Preprotein translocase
I6K90_RS10725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K90_RS10730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K90_RS10740	COG3781	membrane
I6K90_RS10745	COG0613	PHP domain protein
I6K90_RS10755	COG2350	Protein conserved in bacteria
I6K90_RS10785	COG1607	acyl-coa hydrolase
I6K90_RS10855	COG2199	diguanylate cyclase activity
I6K90_RS10865	COG1408	metallophosphoesterase
I6K90_RS10870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K90_RS10880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K90_RS10900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K90_RS10905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K90_RS10920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6K90_RS10930	COG2969	positive regulation of protein catabolic process
I6K90_RS10950	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS10955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6K90_RS10970	COG1309	transcriptional regulator
I6K90_RS10975	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS11020	COG1183	phosphatidylcholine synthase activity
I6K90_RS11025	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K90_RS11055	COG1196	nuclear chromosome segregation
I6K90_RS11055	COG0741	lytic transglycosylase activity
I6K90_RS11055	COG0739	heme binding
I6K90_RS11065	COG1702	phosphate starvation-inducible protein PhoH
I6K90_RS11100	COG1295	ribonuclease BN
I6K90_RS11105	COG0697	spore germination
I6K90_RS11110	COG2169	Transcriptional regulator
I6K90_RS11115	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K90_RS11160	COG0557	exoribonuclease II activity
I6K90_RS11165	COG0339	signal peptide processing
I6K90_RS11170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K90_RS11200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K90_RS11205	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS11360	COG0626	cystathionine gamma-synthase activity
I6K90_RS11365	COG0433	COG0433 Predicted ATPase
I6K90_RS11370	COG1017	nitric oxide dioxygenase activity
I6K90_RS11370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K90_RS11375	COG1959	2 iron, 2 sulfur cluster binding
I6K90_RS11390	COG1301	dicarboxylic acid transport
I6K90_RS11395	COG1946	Acyl-CoA thioesterase
I6K90_RS11415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K90_RS11420	COG1040	competence protein
I6K90_RS11425	COG0494	nUDIX hydrolase
I6K90_RS11445	COG0598	Magnesium transport protein CorA
I6K90_RS11455	COG2854	intermembrane phospholipid transfer
I6K90_RS11465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K90_RS11470	COG1127	ABC transporter
I6K90_RS11480	COG0513	Belongs to the DEAD box helicase family
I6K90_RS11500	COG0408	coproporphyrinogen oxidase activity
I6K90_RS11515	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS11525	COG1983	PspC domain protein
I6K90_RS11530	COG0517	IMP dehydrogenase activity
I6K90_RS11575	COG0583	DNA-binding transcription factor activity
I6K90_RS11615	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS11625	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K90_RS11630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K90_RS11635	COG0833	amino acid
I6K90_RS11665	COG1192	Involved in chromosome partitioning
I6K90_RS11670	COG0628	permease
I6K90_RS11680	COG1289	transmembrane transporter activity
I6K90_RS11695	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K90_RS11700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K90_RS11710	COG0277	FAD linked oxidase domain protein
I6K90_RS11715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K90_RS11740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6K90_RS11745	COG5380	lipid catabolic process
I6K90_RS11765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6K90_RS11815	COG0194	GDP metabolic process
I6K90_RS11830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K90_RS11850	COG3307	-O-antigen
I6K90_RS11865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K90_RS11870	COG1704	LemA family
I6K90_RS11885	COG0493	'glutamate synthase
I6K90_RS11890	COG0069	glutamate synthase activity
I6K90_RS11890	COG0070	glutamate synthase
I6K90_RS11890	COG0067	glutamate synthase
I6K90_RS11940	COG2226	methyltransferase
I6K90_RS11955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K90_RS11960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K90_RS12005	COG0833	amino acid
I6K90_RS12070	COG0488	(ABC) transporter
I6K90_RS12075	COG2873	o-acetylhomoserine
I6K90_RS12080	COG4221	oxidoreductase activity
I6K90_RS12085	COG0659	secondary active sulfate transmembrane transporter activity
I6K90_RS12110	COG0427	acetyl-CoA hydrolase
I6K90_RS12140	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K90_RS12180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K90_RS12240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K90_RS12250	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K90_RS12255	COG1733	regulation of RNA biosynthetic process
I6K90_RS12270	COG1733	regulation of RNA biosynthetic process
I6K90_RS12290	COG0667	Aldo Keto reductase
I6K90_RS12310	COG0583	DNA-binding transcription factor activity
I6K90_RS12315	COG2814	Major facilitator Superfamily
I6K90_RS12345	COG1335	isochorismatase
I6K90_RS12355	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS12360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K90_RS12370	COG1113	amino acid transport
I6K90_RS12380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K90_RS12395	COG2814	Major facilitator Superfamily
I6K90_RS12405	COG0352	thiamine-phosphate diphosphorylase activity
I6K90_RS12405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K90_RS12405	COG0351	phosphomethylpyrimidine kinase
I6K90_RS12425	COG1309	transcriptional regulator
I6K90_RS12430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K90_RS12445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K90_RS12455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K90_RS12460	COG3162	membrane
I6K90_RS12465	COG2205	protein histidine kinase activity
I6K90_RS12465	COG0784	Response regulator, receiver
I6K90_RS12465	COG2198	Histidine kinase
I6K90_RS12490	COG1522	sequence-specific DNA binding
I6K90_RS12495	COG1335	isochorismatase
I6K90_RS12500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K90_RS12510	COG0668	transmembrane transport
I6K90_RS12515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K90_RS12520	COG1519	Transferase
I6K90_RS12525	COG1902	pentaerythritol trinitrate reductase activity
I6K90_RS12545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K90_RS12570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K90_RS12570	COG0426	domain, Protein
I6K90_RS12575	COG4774	siderophore transport
I6K90_RS12580	COG2119	membrane
I6K90_RS12590	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K90_RS12600	COG4942	peptidase
I6K90_RS12615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K90_RS12625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K90_RS12645	COG0189	ligase activity
I6K90_RS12665	COG0708	Exodeoxyribonuclease III
I6K90_RS12670	COG1393	Belongs to the ArsC family
I6K90_RS12685	COG3706	GGDEF domain
I6K90_RS12720	COG2351	hydroxyisourate hydrolase activity
I6K90_RS12725	COG2233	PERMEase
I6K90_RS12735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K90_RS12745	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6K90_RS12755	COG3150	esterase
I6K90_RS12785	COG1388	LysM domain
I6K90_RS12785	COG3409	Peptidoglycan-binding domain 1 protein
I6K90_RS12785	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6K90_RS12800	COG2918	glutathione biosynthetic process
I6K90_RS12815	COG2733	membrane
I6K90_RS12820	COG0436	Aminotransferase
I6K90_RS12825	COG0534	Mate efflux family protein
I6K90_RS12910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K90_RS12915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K90_RS12925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6K90_RS12955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K90_RS12970	COG0010	Belongs to the arginase family
I6K90_RS13000	COG2188	Transcriptional regulator
I6K90_RS13010	COG0523	cobalamin synthesis protein
I6K90_RS13020	COG1113	amino acid transport
I6K90_RS13030	COG0625	glutathione transferase activity
I6K90_RS13050	COG1683	Conserved Protein
I6K90_RS13055	COG0534	Mate efflux family protein
I6K90_RS13060	COG0385	Bile acid
I6K90_RS13065	COG1335	isochorismatase
I6K90_RS13070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K90_RS13090	COG2116	formate transmembrane transporter activity
I6K90_RS13095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K90_RS13100	COG2133	pyrroloquinoline quinone binding
I6K90_RS13105	COG2983	Belongs to the UPF0260 family
I6K90_RS13125	COG1194	a g-specific adenine glycosylase
I6K90_RS13140	COG2818	Glycosylase
I6K90_RS13145	COG1064	alcohol dehydrogenase
I6K90_RS13150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K90_RS13165	COG0583	DNA-binding transcription factor activity
I6K90_RS13170	COG0656	L-ascorbic acid biosynthetic process
I6K90_RS13175	COG2814	Major facilitator Superfamily
I6K90_RS13210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS13225	COG2233	PERMEase
I6K90_RS13230	COG0583	DNA-binding transcription factor activity
I6K90_RS13265	COG0733	neurotransmitter:sodium symporter activity
I6K90_RS13305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6K90_RS13310	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6K90_RS13315	COG0596	Alpha beta hydrolase
I6K90_RS13340	COG0488	(ABC) transporter
I6K90_RS13345	COG0586	Pfam SNARE associated Golgi protein
I6K90_RS13355	COG0187	DNA topoisomerase II activity
I6K90_RS13365	COG0592	DNA-directed DNA polymerase activity
I6K90_RS13395	COG0706	membrane insertase activity
I6K90_RS13410	COG1230	cation diffusion facilitator family transporter
I6K90_RS13415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K90_RS13430	COG0402	S-adenosylhomocysteine deaminase activity
I6K90_RS13440	COG0754	glutathionylspermidine amidase activity
I6K90_RS13450	COG0861	Integral membrane protein TerC family
I6K90_RS13455	COG0671	phosphoesterase, PA-phosphatase related
I6K90_RS13465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K90_RS13480	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K90_RS13485	COG2951	lytic endotransglycosylase activity
I6K90_RS13535	COG0657	acetylesterase activity
I6K90_RS13540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K90_RS13580	COG1047	Peptidyl-prolyl cis-trans
I6K90_RS13590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6K90_RS13595	COG0196	riboflavin kinase activity
I6K90_RS13605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K90_RS13610	COG1309	transcriptional regulator
I6K90_RS13615	COG1116	anion transmembrane transporter activity
I6K90_RS13620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K90_RS13625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K90_RS13630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K90_RS13635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K90_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS13660	COG0546	phosphoglycolate phosphatase activity
I6K90_RS13715	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K90_RS13720	COG0728	peptidoglycan biosynthetic process
I6K90_RS13750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K90_RS13755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K90_RS13760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K90_RS13785	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K90_RS13795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K90_RS13805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K90_RS13820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K90_RS13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K90_RS13835	COG2186	Transcriptional regulator
I6K90_RS13845	COG0277	FAD linked oxidase domain protein
I6K90_RS13850	COG1448	Aminotransferase
I6K90_RS13860	COG1802	Transcriptional regulator
I6K90_RS13875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K90_RS13910	COG0564	pseudouridine synthase activity
I6K90_RS13950	COG0251	oxidation-reduction process
I6K90_RS13955	COG1113	amino acid transport
I6K90_RS13960	COG1113	amino acid transport
I6K90_RS13980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K90_RS13985	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS13990	COG1024	Enoyl-CoA hydratase
I6K90_RS13995	COG1024	Enoyl-CoA hydratase
I6K90_RS14000	COG0477	Major facilitator Superfamily
I6K90_RS14005	COG3916	Acyl-homoserine-lactone synthase
I6K90_RS14015	COG2197	response regulator
I6K90_RS14025	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS14030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K90_RS14030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K90_RS14030	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K90_RS14030	COG3321	synthase
I6K90_RS14050	COG2267	carboxylic ester hydrolase activity
I6K90_RS14070	COG0271	Belongs to the BolA IbaG family
I6K90_RS14080	COG1192	Involved in chromosome partitioning
I6K90_RS14095	COG0586	Pfam SNARE associated Golgi protein
I6K90_RS14100	COG2259	Doxx family
I6K90_RS14105	COG4399	Belongs to the UPF0754 family
I6K90_RS14110	COG0519	Catalyzes the synthesis of GMP from XMP
I6K90_RS14110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6K90_RS14155	COG0281	malic enzyme
I6K90_RS14165	COG2837	iron assimilation
I6K90_RS14170	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS14175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K90_RS14180	COG1121	(ABC) transporter
I6K90_RS14245	COG0386	Belongs to the glutathione peroxidase family
I6K90_RS14260	COG1309	transcriptional regulator
I6K90_RS14265	COG0697	spore germination
I6K90_RS14275	COG0758	DNA mediated transformation
I6K90_RS14310	COG1309	transcriptional regulator
I6K90_RS14345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K90_RS14355	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6K90_RS14390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K90_RS14400	COG2814	Major facilitator Superfamily
I6K90_RS14410	COG1253	flavin adenine dinucleotide binding
I6K90_RS14420	COG2860	membrane
I6K90_RS14425	COG0477	Major facilitator Superfamily
I6K90_RS14435	COG0318	PFAM AMP-dependent synthetase and ligase
I6K90_RS14450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K90_RS14465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K90_RS14475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K90_RS14480	COG0606	chelatase, subunit chli
I6K90_RS14510	COG0589	response to stress
I6K90_RS14515	COG0659	secondary active sulfate transmembrane transporter activity
I6K90_RS14545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6K90_RS14590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K90_RS14665	COG0606	chelatase, subunit chli
I6K90_RS14675	COG0347	Belongs to the P(II) protein family
I6K90_RS14680	COG0004	ammonium transporteR
I6K90_RS14690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K90_RS14690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K90_RS14730	COG0795	lipopolysaccharide-transporting ATPase activity
I6K90_RS14735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6K90_RS14740	COG0793	Belongs to the peptidase S41A family
I6K90_RS14755	COG2197	response regulator
I6K90_RS14765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K90_RS14775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K90_RS14780	COG4974	Belongs to the 'phage' integrase family
I6K90_RS14805	COG0772	Belongs to the SEDS family
I6K90_RS14810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K90_RS14815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K90_RS14820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K90_RS14845	COG0697	spore germination
I6K90_RS14850	COG1538	Outer membrane efflux protein
I6K90_RS14870	COG3275	phosphorelay sensor kinase activity
I6K90_RS14880	COG0181	hydroxymethylbilane synthase activity
I6K90_RS14925	COG1716	ATPase activity
I6K90_RS14930	COG0546	phosphoglycolate phosphatase activity
I6K90_RS15025	COG0596	Alpha beta hydrolase
I6K90_RS15030	COG2056	Na+-H+ antiporter family
I6K90_RS15045	COG0326	Molecular chaperone. Has ATPase activity
I6K90_RS15060	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K90_RS15125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K90_RS15130	COG2169	Transcriptional regulator
I6K90_RS15130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K90_RS15160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6K90_RS15170	COG0497	DNA recombination
I6K90_RS15185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K90_RS15195	COG0237	dephospho-CoA kinase activity
I6K90_RS15245	COG0195	Participates in both transcription termination and antitermination
I6K90_RS15260	COG1320	monovalent cation:proton antiporter activity
I6K90_RS15265	COG2212	antiporter activity
I6K90_RS15270	COG1863	multisubunit Na H antiporter MnhE subunit
I6K90_RS15275	COG0651	ATP synthesis coupled electron transport
I6K90_RS15280	COG1006	Multisubunit Na H antiporter MnhC subunit
I6K90_RS15285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K90_RS15285	COG2111	Na H antiporter
I6K90_RS15300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K90_RS15305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K90_RS15320	COG2226	methyltransferase
I6K90_RS15340	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K90_RS15345	COG1074	ATP-dependent DNA helicase activity
I6K90_RS15350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K90_RS15355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K90_RS15370	COG0598	Magnesium transport protein CorA
I6K90_RS15375	COG0789	Transcriptional regulator
I6K90_RS15380	COG0484	heat shock protein binding
I6K90_RS15390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6K90_RS15395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K90_RS15395	COG0475	glutathione-regulated potassium exporter activity
I6K90_RS15400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K90_RS15420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K90_RS15430	COG4535	Mg2 and Co2 transporter CorC
I6K90_RS15435	COG0425	Belongs to the sulfur carrier protein TusA family
I6K90_RS15440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K90_RS15440	COG0644	oxidoreductase
I6K90_RS15450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K90_RS15465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K90_RS15470	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6K90_RS15510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K90_RS15525	COG0534	Mate efflux family protein
I6K90_RS15535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K90_RS15540	COG4221	oxidoreductase activity
I6K90_RS15545	COG0583	DNA-binding transcription factor activity
I6K90_RS15560	COG0318	PFAM AMP-dependent synthetase and ligase
I6K90_RS15565	COG1530	ribonuclease E activity
I6K90_RS15575	COG0546	phosphoglycolate phosphatase activity
I6K90_RS15580	COG2378	regulation of single-species biofilm formation
I6K90_RS15585	COG0625	glutathione transferase activity
I6K90_RS15595	COG0583	DNA-binding transcription factor activity
I6K90_RS15660	COG0473	3-isopropylmalate dehydrogenase activity
I6K90_RS15715	COG1301	dicarboxylic acid transport
I6K90_RS15725	COG1560	Kdo2-lipid A biosynthetic process
I6K90_RS15730	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS15735	COG0488	(ABC) transporter
I6K90_RS15740	COG2900	Belongs to the SlyX family
I6K90_RS15750	COG1733	regulation of RNA biosynthetic process
I6K90_RS15775	COG0210	DNA helicase
I6K90_RS15780	COG0724	RNA recognition motif
I6K90_RS15800	COG4651	solute:proton antiporter activity
I6K90_RS15800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K90_RS15825	COG0788	formyltetrahydrofolate deformylase activity
I6K90_RS15930	COG2813	Specifically methylates the guanine in position
I6K90_RS15930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K90_RS15940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6K90_RS15965	COG0740	serine-type endopeptidase activity
I6K90_RS15985	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K90_RS15985	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K90_RS15990	COG0280	phosphate acetyltransferase
I6K90_RS15990	COG0857	belongs to the CobB CobQ family
I6K90_RS15995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K90_RS16005	COG0800	Aldolase
I6K90_RS16015	COG3265	gluconokinase activity
I6K90_RS16020	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS16030	COG2267	carboxylic ester hydrolase activity
I6K90_RS16045	COG0793	Belongs to the peptidase S41A family
I6K90_RS16080	COG1426	Protein conserved in bacteria
I6K90_RS16125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K90_RS16135	COG0318	PFAM AMP-dependent synthetase and ligase
I6K90_RS16150	COG2986	histidine ammonia-lyase
I6K90_RS16190	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS16195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K90_RS16215	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K90_RS16225	COG1162	GTPase activity
I6K90_RS16230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6K90_RS16245	COG1538	Outer membrane efflux protein
I6K90_RS16250	COG0577	efflux transmembrane transporter activity
I6K90_RS16250	COG1136	(ABC) transporter
I6K90_RS16255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K90_RS16280	COG0028	Belongs to the TPP enzyme family
I6K90_RS16285	COG0440	acetolactate synthase activity
I6K90_RS16315	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6K90_RS16330	COG0084	hydrolase, TatD family'
I6K90_RS16345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K90_RS16355	COG0583	DNA-binding transcription factor activity
I6K90_RS16365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K90_RS16370	COG2814	Major facilitator Superfamily
I6K90_RS16380	COG0697	spore germination
I6K90_RS16410	COG3622	Belongs to the hyi family
I6K90_RS16415	COG2084	Dehydrogenase
I6K90_RS16420	COG1024	Enoyl-CoA hydratase
I6K90_RS16425	COG0784	Response regulator, receiver
I6K90_RS16425	COG2205	protein histidine kinase activity
I6K90_RS16425	COG5002	protein histidine kinase activity
I6K90_RS16445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K90_RS16475	COG3956	TIGRFAM MazG family protein
I6K90_RS16480	COG1555	photosystem II stabilization
I6K90_RS16485	COG0617	tRNA 3'-terminal CCA addition
I6K90_RS16490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K90_RS16510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K90_RS16515	COG3028	Belongs to the UPF0307 family
I6K90_RS16520	COG0318	PFAM AMP-dependent synthetase and ligase
I6K90_RS16535	COG0625	glutathione transferase activity
I6K90_RS16540	COG1238	metal cluster binding
I6K90_RS16580	COG0072	phenylalanine-tRNA ligase activity
I6K90_RS16610	COG0248	Ppx GppA phosphatase
I6K90_RS16620	COG0037	tRNA processing
I6K90_RS16660	COG1764	response to oxidative stress
I6K90_RS16665	COG1846	Transcriptional regulator
I6K90_RS16675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K90_RS16735	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K90_RS16740	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6K90_RS16745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K90_RS16755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K90_RS16810	COG1214	PFAM Peptidase M22, glycoprotease
I6K90_RS16835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K90_RS16840	COG0561	phosphatase activity
I6K90_RS16850	COG2132	Multicopper oxidase
I6K90_RS16855	COG3667	copper resistance
I6K90_RS16870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K90_RS16875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6K90_RS16880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6K90_RS16910	COG1063	alcohol dehydrogenase
I6K90_RS16915	COG0583	DNA-binding transcription factor activity
I6K90_RS16920	COG1960	acyl-CoA dehydrogenase activity
I6K90_RS16925	COG2814	Major facilitator Superfamily
I6K90_RS16930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K90_RS16940	COG1053	succinate dehydrogenase
I6K90_RS16945	COG0583	DNA-binding transcription factor activity
I6K90_RS16960	COG0583	DNA-binding transcription factor activity
I6K90_RS16990	COG0583	DNA-binding transcription factor activity
I6K90_RS17005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K90_RS17025	COG0384	phenazine biosynthesis protein PhzF
I6K90_RS17050	COG4993	Dehydrogenase
I6K90_RS17140	COG2205	protein histidine kinase activity
I6K90_RS17150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K90_RS17170	COG0745	RESPONSE REGULATOR receiver
I6K90_RS17210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K90_RS17240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K90_RS17245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K90_RS17265	COG0583	DNA-binding transcription factor activity
I6K90_RS17285	COG0668	transmembrane transport
I6K90_RS17295	COG2081	HI0933 family
I6K90_RS17300	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6K90_RS17330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K90_RS17330	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K90_RS17340	COG0489	protein tyrosine kinase activity
I6K90_RS17390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K90_RS17400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K90_RS17415	COG0730	response to heat
I6K90_RS17425	COG1196	nuclear chromosome segregation
I6K90_RS17445	COG2223	nitrite transmembrane transporter activity
I6K90_RS17450	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6K90_RS17455	COG1877	trehalose-phosphatase activity
I6K90_RS17460	COG0596	Alpha beta hydrolase
I6K90_RS17460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6K90_RS17460	COG2226	methyltransferase
I6K90_RS17475	COG4106	trans-aconitate 2-methyltransferase activity
I6K90_RS17490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6K90_RS17495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6K90_RS17500	COG0009	L-threonylcarbamoyladenylate synthase
I6K90_RS17505	COG3101	peptidyl-lysine hydroxylation
I6K90_RS17510	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K90_RS17535	COG1652	LysM domain
I6K90_RS17540	COG0351	phosphomethylpyrimidine kinase
I6K90_RS17540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6K90_RS17540	COG0352	thiamine-phosphate diphosphorylase activity
I6K90_RS17550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6K90_RS17580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K90_RS17610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6K90_RS17625	COG0358	DNA primase activity
I6K90_RS17635	COG0564	pseudouridine synthase activity
I6K90_RS17660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K90_RS17680	COG0583	DNA-binding transcription factor activity
I6K90_RS17685	COG0473	3-isopropylmalate dehydrogenase activity
I6K90_RS17695	COG0657	acetylesterase activity
I6K90_RS17705	COG1012	belongs to the aldehyde dehydrogenase family
I6K90_RS17725	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K90_RS17725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6K90_RS17740	COG1981	membrane
I6K90_RS17785	COG0456	acetyltransferase
I6K90_RS17795	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6K90_RS17800	COG0492	ferredoxin-NADP+ reductase activity
I6K90_RS17805	COG1674	ftsk spoiiie
I6K90_RS17805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K90_RS17810	COG1280	lysine exporter protein (LysE YggA)
I6K90_RS17830	COG2894	cell division
I6K90_RS17845	COG0204	Acyl-transferase
I6K90_RS17850	COG2885	chlorophyll binding
I6K90_RS17855	COG0210	DNA helicase
I6K90_RS17865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K90_RS17880	COG0121	glutamine amidotransferase
I6K90_RS17900	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K90_RS17905	COG0735	belongs to the Fur family
I6K90_RS17930	COG0420	3'-5' exonuclease activity
I6K90_RS17950	COG1090	epimerase
I6K90_RS17965	COG2050	protein possibly involved in aromatic compounds catabolism
I6K90_RS17975	COG2814	Major facilitator Superfamily
I6K90_RS17980	COG0405	Gamma-glutamyltransferase
I6K90_RS18050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K90_RS18150	COG1484	DNA-dependent DNA replication
I6K90_RS18160	COG2826	transposase and inactivated derivatives, IS30 family
I6K90_RS18200	COG3755	Protein conserved in bacteria
I6K90_RS18350	COG2026	Addiction module toxin, RelE StbE family
I6K90_RS18390	COG0592	DNA-directed DNA polymerase activity
I6K90_RS18505	COG0477	Major facilitator Superfamily
I6K90_RS18510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K90_RS18535	COG0531	amino acid
I6K90_RS18540	COG2040	homocysteine
I6K90_RS18565	COG1309	transcriptional regulator
I6K90_RS18570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K90_RS18575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K90_RS18585	COG1607	acyl-coa hydrolase
I6K90_RS18595	COG0523	cobalamin synthesis protein
I6K90_RS18605	COG4681	YaeQ
I6K90_RS18615	COG0726	polysaccharide deacetylase
I6K90_RS18615	COG1649	PFAM Uncharacterised BCR, COG1649
I6K90_RS18620	COG1215	transferase activity, transferring glycosyl groups
I6K90_RS18630	COG1024	Enoyl-CoA hydratase
I6K90_RS18645	COG1414	Transcriptional regulator
I6K90_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS18675	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K90_RS18680	COG2271	Major facilitator Superfamily
I6K90_RS18690	COG2267	carboxylic ester hydrolase activity
I6K90_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS18710	COG0028	Belongs to the TPP enzyme family
I6K90_RS18720	COG0477	Major facilitator Superfamily
I6K90_RS18725	COG0242	peptide deformylase activity
I6K90_RS18730	COG2066	Belongs to the glutaminase family
I6K90_RS18735	COG2207	Transcriptional regulator
I6K90_RS18740	COG2223	nitrite transmembrane transporter activity
I6K90_RS18755	COG0583	DNA-binding transcription factor activity
I6K90_RS18760	COG1028	Short-chain dehydrogenase reductase Sdr
I6K90_RS18765	COG2271	Major facilitator Superfamily
I6K90_RS18770	COG3959	Transketolase, thiamine diphosphate binding domain
I6K90_RS18775	COG3958	Transketolase
I6K90_RS18785	COG0306	phosphate transporter
I6K90_RS18805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6K90_RS18850	COG4181	ATPase activity
I6K90_RS18855	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K90_RS18880	COG0583	DNA-binding transcription factor activity
I6K90_RS18890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K90_RS18895	COG1773	rubredoxin
I6K90_RS18945	COG2851	Citrate transporter
I6K90_RS18950	COG1253	flavin adenine dinucleotide binding
I6K90_RS18990	COG0804	urea catabolic process
I6K90_RS19000	COG0830	nickel cation binding
I6K90_RS19015	COG0742	ribosomal rna small subunit methyltransferase
I6K90_RS19020	COG0768	penicillin binding
I6K90_RS19045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K90_RS19050	COG2878	Part of a membrane complex involved in electron transport
I6K90_RS19055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K90_RS19070	COG3384	dioxygenase
I6K90_RS19095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K90_RS19190	COG3853	Toxic anion resistance protein (TelA)
I6K90_RS19205	COG1475	DNA binding
I6K90_RS19275	COG1525	nuclease
I6K90_RS19345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K90_RS19425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K90_RS19460	COG0741	lytic transglycosylase activity
I6K90_RS19490	COG2826	transposase and inactivated derivatives, IS30 family
I6K90_RS19500	COG2826	transposase and inactivated derivatives, IS30 family
I6K90_RS19560	COG0484	heat shock protein binding
I6K90_RS19680	COG2832	Protein of unknown function (DUF454)