locus-tag	class	description
JCR18_RS00020	COG0706	membrane insertase activity
JCR18_RS00035	COG1230	cation diffusion facilitator family transporter
JCR18_RS00040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JCR18_RS00055	COG0402	S-adenosylhomocysteine deaminase activity
JCR18_RS00065	COG0754	glutathionylspermidine amidase activity
JCR18_RS00075	COG0861	Integral membrane protein TerC family
JCR18_RS00080	COG0671	phosphoesterase, PA-phosphatase related
JCR18_RS00090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JCR18_RS00105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JCR18_RS00110	COG2951	lytic endotransglycosylase activity
JCR18_RS00160	COG0657	acetylesterase activity
JCR18_RS00165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JCR18_RS00205	COG1047	Peptidyl-prolyl cis-trans
JCR18_RS00215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JCR18_RS00220	COG0196	riboflavin kinase activity
JCR18_RS00230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JCR18_RS00235	COG1309	transcriptional regulator
JCR18_RS00240	COG1116	anion transmembrane transporter activity
JCR18_RS00245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JCR18_RS00250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JCR18_RS00255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JCR18_RS00260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JCR18_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS00285	COG0546	phosphoglycolate phosphatase activity
JCR18_RS00340	COG3023	N-Acetylmuramoyl-L-alanine amidase
JCR18_RS00345	COG0728	peptidoglycan biosynthetic process
JCR18_RS00370	COG1596	polysaccharide export
JCR18_RS00375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JCR18_RS00435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JCR18_RS00440	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JCR18_RS00445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JCR18_RS00460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JCR18_RS00465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JCR18_RS00475	COG2186	Transcriptional regulator
JCR18_RS00485	COG0277	FAD linked oxidase domain protein
JCR18_RS00490	COG1448	Aminotransferase
JCR18_RS00500	COG1802	Transcriptional regulator
JCR18_RS00515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
JCR18_RS00580	COG0564	pseudouridine synthase activity
JCR18_RS00620	COG0251	oxidation-reduction process
JCR18_RS00625	COG1113	amino acid transport
JCR18_RS00630	COG1113	amino acid transport
JCR18_RS00650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JCR18_RS00655	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS00660	COG1024	Enoyl-CoA hydratase
JCR18_RS00665	COG1024	Enoyl-CoA hydratase
JCR18_RS00670	COG0477	Major facilitator Superfamily
JCR18_RS00675	COG3916	Acyl-homoserine-lactone synthase
JCR18_RS00685	COG2197	response regulator
JCR18_RS00700	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS00705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JCR18_RS00705	COG3321	synthase
JCR18_RS00705	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
JCR18_RS00705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JCR18_RS00745	COG0271	Belongs to the BolA IbaG family
JCR18_RS00755	COG1192	Involved in chromosome partitioning
JCR18_RS00770	COG0586	Pfam SNARE associated Golgi protein
JCR18_RS00775	COG2259	Doxx family
JCR18_RS00780	COG4399	Belongs to the UPF0754 family
JCR18_RS00785	COG0519	Catalyzes the synthesis of GMP from XMP
JCR18_RS00785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JCR18_RS00830	COG0281	malic enzyme
JCR18_RS00835	COG2837	iron assimilation
JCR18_RS00840	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JCR18_RS00850	COG1121	(ABC) transporter
JCR18_RS00915	COG0386	Belongs to the glutathione peroxidase family
JCR18_RS00930	COG1309	transcriptional regulator
JCR18_RS00935	COG0697	spore germination
JCR18_RS00945	COG0758	DNA mediated transformation
JCR18_RS00980	COG1309	transcriptional regulator
JCR18_RS01015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JCR18_RS01025	COG0655	NAD(P)H dehydrogenase (quinone) activity
JCR18_RS01060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JCR18_RS01080	COG1253	flavin adenine dinucleotide binding
JCR18_RS01090	COG2860	membrane
JCR18_RS01095	COG0477	Major facilitator Superfamily
JCR18_RS01105	COG0318	PFAM AMP-dependent synthetase and ligase
JCR18_RS01120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JCR18_RS01135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JCR18_RS01145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCR18_RS01150	COG0606	chelatase, subunit chli
JCR18_RS01180	COG0589	response to stress
JCR18_RS01185	COG0659	secondary active sulfate transmembrane transporter activity
JCR18_RS01195	COG0606	chelatase, subunit chli
JCR18_RS01205	COG0347	Belongs to the P(II) protein family
JCR18_RS01210	COG0004	ammonium transporteR
JCR18_RS01220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JCR18_RS01220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JCR18_RS01260	COG0795	lipopolysaccharide-transporting ATPase activity
JCR18_RS01265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JCR18_RS01270	COG0793	Belongs to the peptidase S41A family
JCR18_RS01285	COG2197	response regulator
JCR18_RS01295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JCR18_RS01305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JCR18_RS01310	COG4974	Belongs to the 'phage' integrase family
JCR18_RS01335	COG0772	Belongs to the SEDS family
JCR18_RS01340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JCR18_RS01345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JCR18_RS01350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JCR18_RS01375	COG0697	spore germination
JCR18_RS01380	COG1538	Outer membrane efflux protein
JCR18_RS01400	COG3275	phosphorelay sensor kinase activity
JCR18_RS01410	COG0181	hydroxymethylbilane synthase activity
JCR18_RS01455	COG1716	ATPase activity
JCR18_RS01460	COG0546	phosphoglycolate phosphatase activity
JCR18_RS01555	COG0596	Alpha beta hydrolase
JCR18_RS01560	COG2056	Na+-H+ antiporter family
JCR18_RS01575	COG0326	Molecular chaperone. Has ATPase activity
JCR18_RS01590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JCR18_RS01655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JCR18_RS01660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JCR18_RS01660	COG2169	Transcriptional regulator
JCR18_RS01690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JCR18_RS01700	COG0497	DNA recombination
JCR18_RS01715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JCR18_RS01725	COG0237	dephospho-CoA kinase activity
JCR18_RS01775	COG0195	Participates in both transcription termination and antitermination
JCR18_RS01790	COG1320	monovalent cation:proton antiporter activity
JCR18_RS01795	COG2212	antiporter activity
JCR18_RS01800	COG1863	multisubunit Na H antiporter MnhE subunit
JCR18_RS01805	COG0651	ATP synthesis coupled electron transport
JCR18_RS01810	COG1006	Multisubunit Na H antiporter MnhC subunit
JCR18_RS01815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JCR18_RS01815	COG2111	Na H antiporter
JCR18_RS01830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JCR18_RS01835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JCR18_RS01850	COG2226	methyltransferase
JCR18_RS01870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JCR18_RS01875	COG1074	ATP-dependent DNA helicase activity
JCR18_RS01880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JCR18_RS01885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JCR18_RS01900	COG0598	Magnesium transport protein CorA
JCR18_RS01905	COG0789	Transcriptional regulator
JCR18_RS01910	COG0484	heat shock protein binding
JCR18_RS01920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JCR18_RS01925	COG0475	glutathione-regulated potassium exporter activity
JCR18_RS01925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JCR18_RS01930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JCR18_RS01950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCR18_RS01960	COG4535	Mg2 and Co2 transporter CorC
JCR18_RS01965	COG0425	Belongs to the sulfur carrier protein TusA family
JCR18_RS01970	COG0644	oxidoreductase
JCR18_RS01970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
JCR18_RS01980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JCR18_RS01995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JCR18_RS02000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JCR18_RS02040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JCR18_RS02055	COG0534	Mate efflux family protein
JCR18_RS02065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JCR18_RS02070	COG4221	oxidoreductase activity
JCR18_RS02075	COG0583	DNA-binding transcription factor activity
JCR18_RS02090	COG0318	PFAM AMP-dependent synthetase and ligase
JCR18_RS02095	COG1530	ribonuclease E activity
JCR18_RS02105	COG0546	phosphoglycolate phosphatase activity
JCR18_RS02110	COG2378	regulation of single-species biofilm formation
JCR18_RS02115	COG0625	glutathione transferase activity
JCR18_RS02125	COG0583	DNA-binding transcription factor activity
JCR18_RS02160	COG1061	Type III restriction enzyme res subunit
JCR18_RS02170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JCR18_RS02175	COG1192	Involved in chromosome partitioning
JCR18_RS02240	COG0473	3-isopropylmalate dehydrogenase activity
JCR18_RS02295	COG1301	dicarboxylic acid transport
JCR18_RS02305	COG1560	Kdo2-lipid A biosynthetic process
JCR18_RS02310	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS02315	COG0488	(ABC) transporter
JCR18_RS02320	COG2900	Belongs to the SlyX family
JCR18_RS02330	COG1733	regulation of RNA biosynthetic process
JCR18_RS02355	COG0210	DNA helicase
JCR18_RS02360	COG0724	RNA recognition motif
JCR18_RS02380	COG4651	solute:proton antiporter activity
JCR18_RS02380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JCR18_RS02405	COG0788	formyltetrahydrofolate deformylase activity
JCR18_RS02505	COG2813	Specifically methylates the guanine in position
JCR18_RS02505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JCR18_RS02515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JCR18_RS02525	COG4774	siderophore transport
JCR18_RS02535	COG0740	serine-type endopeptidase activity
JCR18_RS02555	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JCR18_RS02555	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JCR18_RS02560	COG0280	phosphate acetyltransferase
JCR18_RS02560	COG0857	belongs to the CobB CobQ family
JCR18_RS02565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JCR18_RS02580	COG0800	Aldolase
JCR18_RS02590	COG3265	gluconokinase activity
JCR18_RS02595	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS02605	COG2267	carboxylic ester hydrolase activity
JCR18_RS02620	COG0793	Belongs to the peptidase S41A family
JCR18_RS02655	COG1426	Protein conserved in bacteria
JCR18_RS02700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JCR18_RS02710	COG0318	PFAM AMP-dependent synthetase and ligase
JCR18_RS02725	COG2986	histidine ammonia-lyase
JCR18_RS02765	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS02770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JCR18_RS02790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JCR18_RS02800	COG1162	GTPase activity
JCR18_RS02805	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JCR18_RS02820	COG1538	Outer membrane efflux protein
JCR18_RS02825	COG1136	(ABC) transporter
JCR18_RS02825	COG0577	efflux transmembrane transporter activity
JCR18_RS02830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS02855	COG0028	Belongs to the TPP enzyme family
JCR18_RS02860	COG0440	acetolactate synthase activity
JCR18_RS02890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JCR18_RS02905	COG0084	hydrolase, TatD family'
JCR18_RS02920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JCR18_RS02930	COG0583	DNA-binding transcription factor activity
JCR18_RS02940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JCR18_RS02945	COG2814	Major facilitator Superfamily
JCR18_RS02955	COG0697	spore germination
JCR18_RS02985	COG3622	Belongs to the hyi family
JCR18_RS02990	COG2084	Dehydrogenase
JCR18_RS02995	COG1024	Enoyl-CoA hydratase
JCR18_RS03000	COG0784	Response regulator, receiver
JCR18_RS03000	COG5002	protein histidine kinase activity
JCR18_RS03000	COG2205	protein histidine kinase activity
JCR18_RS03020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JCR18_RS03030	COG3956	TIGRFAM MazG family protein
JCR18_RS03035	COG1555	photosystem II stabilization
JCR18_RS03040	COG0617	tRNA 3'-terminal CCA addition
JCR18_RS03045	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JCR18_RS03065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCR18_RS03070	COG3028	Belongs to the UPF0307 family
JCR18_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
JCR18_RS03090	COG0625	glutathione transferase activity
JCR18_RS03095	COG1238	metal cluster binding
JCR18_RS03135	COG0072	phenylalanine-tRNA ligase activity
JCR18_RS03165	COG0248	Ppx GppA phosphatase
JCR18_RS03175	COG0037	tRNA processing
JCR18_RS03215	COG1764	response to oxidative stress
JCR18_RS03220	COG1846	Transcriptional regulator
JCR18_RS03230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JCR18_RS03290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JCR18_RS03295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JCR18_RS03300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JCR18_RS03310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JCR18_RS03360	COG1214	PFAM Peptidase M22, glycoprotease
JCR18_RS03385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JCR18_RS03390	COG0561	phosphatase activity
JCR18_RS03400	COG2132	Multicopper oxidase
JCR18_RS03405	COG3667	copper resistance
JCR18_RS03420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JCR18_RS03425	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
JCR18_RS03430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JCR18_RS03460	COG1063	alcohol dehydrogenase
JCR18_RS03465	COG0583	DNA-binding transcription factor activity
JCR18_RS03470	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS03475	COG2814	Major facilitator Superfamily
JCR18_RS03480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JCR18_RS03490	COG1053	succinate dehydrogenase
JCR18_RS03495	COG0583	DNA-binding transcription factor activity
JCR18_RS03510	COG0583	DNA-binding transcription factor activity
JCR18_RS03540	COG0583	DNA-binding transcription factor activity
JCR18_RS03555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCR18_RS03585	COG1192	Involved in chromosome partitioning
JCR18_RS03590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JCR18_RS03600	COG1061	Type III restriction enzyme res subunit
JCR18_RS03625	COG0384	phenazine biosynthesis protein PhzF
JCR18_RS03655	COG4993	Dehydrogenase
JCR18_RS03735	COG2205	protein histidine kinase activity
JCR18_RS03745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JCR18_RS03765	COG0745	RESPONSE REGULATOR receiver
JCR18_RS03805	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JCR18_RS03835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JCR18_RS03840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JCR18_RS03860	COG0583	DNA-binding transcription factor activity
JCR18_RS03880	COG0668	transmembrane transport
JCR18_RS03890	COG2081	HI0933 family
JCR18_RS03895	COG2515	1-aminocyclopropane-1-carboxylate deaminase
JCR18_RS03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCR18_RS03925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCR18_RS03935	COG0489	protein tyrosine kinase activity
JCR18_RS03985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JCR18_RS03995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JCR18_RS04010	COG0730	response to heat
JCR18_RS04020	COG1196	nuclear chromosome segregation
JCR18_RS04040	COG2223	nitrite transmembrane transporter activity
JCR18_RS04045	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
JCR18_RS04050	COG1877	trehalose-phosphatase activity
JCR18_RS04055	COG0596	Alpha beta hydrolase
JCR18_RS04055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JCR18_RS04055	COG2226	methyltransferase
JCR18_RS04070	COG4106	trans-aconitate 2-methyltransferase activity
JCR18_RS04085	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JCR18_RS04090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JCR18_RS04095	COG0009	L-threonylcarbamoyladenylate synthase
JCR18_RS04100	COG3101	peptidyl-lysine hydroxylation
JCR18_RS04105	COG1399	metal-binding, possibly nucleic acid-binding protein
JCR18_RS04130	COG1652	LysM domain
JCR18_RS04135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JCR18_RS04135	COG0352	thiamine-phosphate diphosphorylase activity
JCR18_RS04135	COG0351	phosphomethylpyrimidine kinase
JCR18_RS04145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JCR18_RS04175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JCR18_RS04205	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
JCR18_RS04220	COG0358	DNA primase activity
JCR18_RS04230	COG0564	pseudouridine synthase activity
JCR18_RS04255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JCR18_RS04275	COG0583	DNA-binding transcription factor activity
JCR18_RS04280	COG0473	3-isopropylmalate dehydrogenase activity
JCR18_RS04290	COG0657	acetylesterase activity
JCR18_RS04300	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS04320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JCR18_RS04320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JCR18_RS04335	COG1981	membrane
JCR18_RS04385	COG0456	acetyltransferase
JCR18_RS04395	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JCR18_RS04400	COG0492	ferredoxin-NADP+ reductase activity
JCR18_RS04405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JCR18_RS04405	COG1674	ftsk spoiiie
JCR18_RS04410	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS04435	COG2894	cell division
JCR18_RS04450	COG0204	Acyl-transferase
JCR18_RS04455	COG2885	chlorophyll binding
JCR18_RS04460	COG0210	DNA helicase
JCR18_RS04470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JCR18_RS04485	COG0121	glutamine amidotransferase
JCR18_RS04505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JCR18_RS04510	COG0735	belongs to the Fur family
JCR18_RS04535	COG0420	3'-5' exonuclease activity
JCR18_RS04555	COG1090	epimerase
JCR18_RS04570	COG2050	protein possibly involved in aromatic compounds catabolism
JCR18_RS04580	COG2814	Major facilitator Superfamily
JCR18_RS04585	COG0405	Gamma-glutamyltransferase
JCR18_RS04685	COG3620	sequence-specific DNA binding
JCR18_RS04750	COG1484	DNA-dependent DNA replication
JCR18_RS04955	COG2026	Addiction module toxin, RelE StbE family
JCR18_RS04995	COG0592	DNA-directed DNA polymerase activity
JCR18_RS05125	COG0477	Major facilitator Superfamily
JCR18_RS05130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JCR18_RS05140	COG1595	DNA-templated transcription, initiation
JCR18_RS05195	COG0531	amino acid
JCR18_RS05200	COG2040	homocysteine
JCR18_RS05225	COG1309	transcriptional regulator
JCR18_RS05230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JCR18_RS05235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JCR18_RS05245	COG1607	acyl-coa hydrolase
JCR18_RS05255	COG0523	cobalamin synthesis protein
JCR18_RS05265	COG4681	YaeQ
JCR18_RS05275	COG1649	PFAM Uncharacterised BCR, COG1649
JCR18_RS05275	COG0726	polysaccharide deacetylase
JCR18_RS05280	COG1215	transferase activity, transferring glycosyl groups
JCR18_RS05290	COG1024	Enoyl-CoA hydratase
JCR18_RS05305	COG1414	Transcriptional regulator
JCR18_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS05335	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCR18_RS05340	COG2271	Major facilitator Superfamily
JCR18_RS05350	COG2267	carboxylic ester hydrolase activity
JCR18_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS05370	COG0028	Belongs to the TPP enzyme family
JCR18_RS05380	COG0477	Major facilitator Superfamily
JCR18_RS05385	COG0242	peptide deformylase activity
JCR18_RS05390	COG2066	Belongs to the glutaminase family
JCR18_RS05395	COG2207	Transcriptional regulator
JCR18_RS05400	COG2223	nitrite transmembrane transporter activity
JCR18_RS05415	COG0583	DNA-binding transcription factor activity
JCR18_RS05420	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS05425	COG2271	Major facilitator Superfamily
JCR18_RS05430	COG3959	Transketolase, thiamine diphosphate binding domain
JCR18_RS05435	COG3958	Transketolase
JCR18_RS05445	COG0306	phosphate transporter
JCR18_RS05465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
JCR18_RS05510	COG4181	ATPase activity
JCR18_RS05515	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JCR18_RS05540	COG0583	DNA-binding transcription factor activity
JCR18_RS05550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JCR18_RS05555	COG1773	rubredoxin
JCR18_RS05605	COG2851	Citrate transporter
JCR18_RS05610	COG1253	flavin adenine dinucleotide binding
JCR18_RS05650	COG0804	urea catabolic process
JCR18_RS05660	COG0830	nickel cation binding
JCR18_RS05675	COG0742	ribosomal rna small subunit methyltransferase
JCR18_RS05680	COG0768	penicillin binding
JCR18_RS05705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JCR18_RS05710	COG2878	Part of a membrane complex involved in electron transport
JCR18_RS05715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JCR18_RS05725	COG3384	dioxygenase
JCR18_RS05750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JCR18_RS06075	COG0739	heme binding
JCR18_RS06120	COG2194	sulfuric ester hydrolase activity
JCR18_RS06160	COG0006	proline dipeptidase activity
JCR18_RS06165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JCR18_RS06170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JCR18_RS06190	COG1279	arginine transmembrane transporter activity
JCR18_RS06195	COG0583	DNA-binding transcription factor activity
JCR18_RS06235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JCR18_RS06240	COG0741	lytic transglycosylase activity
JCR18_RS06240	COG0741	lytic transglycosylase activity
JCR18_RS06240	COG1388	LysM domain
JCR18_RS06240	COG1388	LysM domain
JCR18_RS06250	COG4174	ABC transporter (Permease)
JCR18_RS06255	COG4239	(ABC) transporter, permease
JCR18_RS06260	COG4172	Belongs to the ABC transporter superfamily
JCR18_RS06280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JCR18_RS06290	COG3706	GGDEF domain
JCR18_RS06290	COG2203	Gaf domain
JCR18_RS06290	COG4251	negative regulation of phosphorylation
JCR18_RS06290	COG5001	Diguanylate cyclase
JCR18_RS06300	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCR18_RS06300	COG1902	pentaerythritol trinitrate reductase activity
JCR18_RS06315	COG4269	membrane
JCR18_RS06360	COG0300	oxidoreductase activity
JCR18_RS06370	COG1309	transcriptional regulator
JCR18_RS06375	COG1741	Belongs to the pirin family
JCR18_RS06390	COG2072	flavoprotein involved in K transport
JCR18_RS06400	COG2252	PERMEase
JCR18_RS06405	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JCR18_RS06410	COG3038	cytochrome b561
JCR18_RS06420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JCR18_RS06430	COG0527	aspartate kinase activity
JCR18_RS06440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JCR18_RS06450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JCR18_RS06465	COG0667	Aldo Keto reductase
JCR18_RS06485	COG1765	OsmC-like protein
JCR18_RS06500	COG0542	response to heat
JCR18_RS06535	COG2885	chlorophyll binding
JCR18_RS06545	COG0625	glutathione transferase activity
JCR18_RS06550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JCR18_RS06570	COG3634	alkyl hydroperoxide reductase activity
JCR18_RS06580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JCR18_RS06590	COG0450	alkyl hydroperoxide reductase
JCR18_RS06595	COG1643	Atp-dependent helicase
JCR18_RS06610	COG2814	Major facilitator Superfamily
JCR18_RS06615	COG3135	benzoate transporter
JCR18_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS06625	COG0633	Ferredoxin
JCR18_RS06625	COG0543	2 iron, 2 sulfur cluster binding
JCR18_RS06630	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
JCR18_RS06635	COG4638	Rieske (2fe-2S)
JCR18_RS06640	COG0583	DNA-binding transcription factor activity
JCR18_RS06690	COG1570	exodeoxyribonuclease VII activity
JCR18_RS06720	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS06725	COG1278	Cold shock
JCR18_RS06760	COG2814	Major facilitator Superfamily
JCR18_RS06800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JCR18_RS06800	COG0517	IMP dehydrogenase activity
JCR18_RS06805	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JCR18_RS06815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JCR18_RS06820	COG1137	ATPase activity
JCR18_RS06825	COG1538	Outer membrane efflux protein
JCR18_RS06855	COG4122	O-methyltransferase activity
JCR18_RS06865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
JCR18_RS06880	COG1522	sequence-specific DNA binding
JCR18_RS06885	COG5006	permease, DMT superfamily
JCR18_RS06895	COG1560	Kdo2-lipid A biosynthetic process
JCR18_RS06905	COG2814	Major facilitator Superfamily
JCR18_RS06925	COG1250	3-hydroxyacyl-CoA dehydrogenase
JCR18_RS06975	COG0583	DNA-binding transcription factor activity
JCR18_RS06980	COG1914	H( )-stimulated, divalent metal cation uptake system
JCR18_RS07000	COG4770	biotin carboxylase activity
JCR18_RS07005	COG0038	chloride channel
JCR18_RS07025	COG1309	transcriptional regulator
JCR18_RS07035	COG1063	alcohol dehydrogenase
JCR18_RS07050	COG0439	Biotin carboxylase
JCR18_RS07055	COG2249	NAD(P)H dehydrogenase (quinone) activity
JCR18_RS07075	COG0864	Transcriptional regulator
JCR18_RS07085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCR18_RS07090	COG1116	anion transmembrane transporter activity
JCR18_RS07110	COG0789	Transcriptional regulator
JCR18_RS07120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JCR18_RS07140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JCR18_RS07150	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCR18_RS07165	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS07170	COG0531	amino acid
JCR18_RS07175	COG1760	l-serine dehydratase
JCR18_RS07180	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS07180	COG2030	dehydratase
JCR18_RS07185	COG3396	Phenylacetate-CoA oxygenase
JCR18_RS07190	COG3460	Phenylacetate-CoA oxygenase
JCR18_RS07195	COG3396	Phenylacetate-CoA oxygenase
JCR18_RS07200	COG2151	metal-sulfur cluster biosynthetic enzyme
JCR18_RS07205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JCR18_RS07210	COG1024	Enoyl-CoA hydratase
JCR18_RS07215	COG1024	Enoyl-CoA hydratase
JCR18_RS07220	COG1250	3-hydroxyacyl-CoA dehydrogenase
JCR18_RS07225	COG0183	Belongs to the thiolase family
JCR18_RS07230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
JCR18_RS07235	COG3327	negative regulation of DNA-templated transcription, initiation
JCR18_RS07245	COG2050	protein possibly involved in aromatic compounds catabolism
JCR18_RS07280	COG0753	catalase activity
JCR18_RS07285	COG3038	cytochrome b561
JCR18_RS07305	COG2267	carboxylic ester hydrolase activity
JCR18_RS07310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCR18_RS07315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JCR18_RS07320	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS07330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JCR18_RS07340	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS07345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JCR18_RS07350	COG0583	DNA-binding transcription factor activity
JCR18_RS07360	COG1414	Transcriptional regulator
JCR18_RS07365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JCR18_RS07375	COG1840	ABC-type Fe3 transport system, periplasmic component
JCR18_RS07380	COG3842	ATPase activity
JCR18_RS07395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JCR18_RS07400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCR18_RS07405	COG2814	Major facilitator Superfamily
JCR18_RS07410	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS07425	COG1024	Enoyl-CoA hydratase
JCR18_RS07435	COG2814	Major facilitator Superfamily
JCR18_RS07445	COG0183	Belongs to the thiolase family
JCR18_RS07450	COG1250	3-hydroxyacyl-CoA dehydrogenase
JCR18_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS07460	COG1024	Enoyl-CoA hydratase
JCR18_RS07465	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS07470	COG2814	Major facilitator Superfamily
JCR18_RS07475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JCR18_RS07480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JCR18_RS07490	COG2814	Major facilitator Superfamily
JCR18_RS07500	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS07515	COG0583	DNA-binding transcription factor activity
JCR18_RS07525	COG4770	biotin carboxylase activity
JCR18_RS07530	COG1024	Enoyl-CoA hydratase
JCR18_RS07535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JCR18_RS07540	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS07545	COG1309	transcriptional regulator
JCR18_RS07550	COG0318	PFAM AMP-dependent synthetase and ligase
JCR18_RS07570	COG0583	DNA-binding transcription factor activity
JCR18_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS07640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JCR18_RS07660	COG2205	protein histidine kinase activity
JCR18_RS07660	COG0784	Response regulator, receiver
JCR18_RS07680	COG0765	amino acid transport
JCR18_RS07685	COG0765	amino acid transport
JCR18_RS07690	COG1126	abc transporter atp-binding protein
JCR18_RS07695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCR18_RS07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCR18_RS07715	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS07725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JCR18_RS07730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCR18_RS07735	COG1045	serine acetyltransferase
JCR18_RS07750	COG0583	DNA-binding transcription factor activity
JCR18_RS07755	COG0625	glutathione transferase activity
JCR18_RS07760	COG0625	glutathione transferase activity
JCR18_RS07765	COG0583	DNA-binding transcription factor activity
JCR18_RS07775	COG1346	cytolysis
JCR18_RS07795	COG2814	Major facilitator Superfamily
JCR18_RS07805	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
JCR18_RS07810	COG3052	prosthetic group binding
JCR18_RS07830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JCR18_RS07850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCR18_RS07860	COG1294	oxidase, subunit
JCR18_RS07865	COG1271	oxidase subunit
JCR18_RS07885	COG0477	Major facilitator Superfamily
JCR18_RS07895	COG4521	taurine ABC transporter
JCR18_RS07900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
JCR18_RS07905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JCR18_RS07910	COG2175	clavaminate synthase activity
JCR18_RS07920	COG1953	Uracil, thiamine, allantoin
JCR18_RS07930	COG0583	DNA-binding transcription factor activity
JCR18_RS07940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JCR18_RS07955	COG0640	Transcriptional regulator
JCR18_RS07960	COG0798	PFAM Bile acid sodium symporter
JCR18_RS07965	COG0583	DNA-binding transcription factor activity
JCR18_RS07980	COG3634	alkyl hydroperoxide reductase activity
JCR18_RS08020	COG0436	Aminotransferase
JCR18_RS08030	COG0386	Belongs to the glutathione peroxidase family
JCR18_RS08070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JCR18_RS08095	COG0012	GTP binding
JCR18_RS08100	COG2011	ABC-type metal ion transport system permease component
JCR18_RS08105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JCR18_RS08115	COG1464	Belongs to the NlpA lipoprotein family
JCR18_RS08145	COG0765	amino acid transport
JCR18_RS08150	COG0765	amino acid transport
JCR18_RS08155	COG1126	abc transporter atp-binding protein
JCR18_RS08165	COG1522	sequence-specific DNA binding
JCR18_RS08185	COG1309	transcriptional regulator
JCR18_RS08205	COG0583	DNA-binding transcription factor activity
JCR18_RS08215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
JCR18_RS08225	COG0697	spore germination
JCR18_RS08250	COG3121	Chaperone
JCR18_RS08255	COG3539	Fimbrial protein
JCR18_RS08280	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JCR18_RS08280	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JCR18_RS08325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JCR18_RS08335	COG2353	YceI-like domain
JCR18_RS08345	COG3698	Phosphodiester glycosidase
JCR18_RS08360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JCR18_RS08365	COG0506	proline dehydrogenase activity
JCR18_RS08365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JCR18_RS08365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JCR18_RS08375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JCR18_RS08380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JCR18_RS08400	COG1132	(ABC) transporter
JCR18_RS08405	COG3122	Protein conserved in bacteria
JCR18_RS08410	COG3619	membrane
JCR18_RS08420	COG0640	Transcriptional regulator
JCR18_RS08430	COG2850	peptidyl-arginine hydroxylation
JCR18_RS08435	COG0424	maF-like protein
JCR18_RS08455	COG0191	fructose-bisphosphate aldolase activity
JCR18_RS08460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JCR18_RS08475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
JCR18_RS08485	COG1192	Involved in chromosome partitioning
JCR18_RS08490	COG1475	DNA binding
JCR18_RS08495	COG0811	peptide transport
JCR18_RS08505	COG1132	(ABC) transporter
JCR18_RS08510	COG1663	tetraacyldisaccharide 4'-kinase activity
JCR18_RS08530	COG0084	hydrolase, TatD family'
JCR18_RS08595	COG0776	regulation of translation
JCR18_RS08625	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JCR18_RS08630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JCR18_RS08680	COG0339	signal peptide processing
JCR18_RS08690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JCR18_RS08725	COG0702	epimerase
JCR18_RS08730	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JCR18_RS08750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JCR18_RS08780	COG0316	Belongs to the HesB IscA family
JCR18_RS08785	COG0822	iron-sulfur transferase activity
JCR18_RS08810	COG0776	regulation of translation
JCR18_RS08815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JCR18_RS08820	COG2207	Transcriptional regulator
JCR18_RS08825	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JCR18_RS08830	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS08835	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS08850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JCR18_RS08870	COG4264	IucA IucC family
JCR18_RS08875	COG4264	IucA IucC family
JCR18_RS08915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCR18_RS08930	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
JCR18_RS08950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JCR18_RS08975	COG4773	Receptor
JCR18_RS08980	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JCR18_RS08995	COG1131	(ABC) transporter
JCR18_RS09000	COG0842	Transport permease protein
JCR18_RS09005	COG0842	Transport permease protein
JCR18_RS09060	COG2226	methyltransferase
JCR18_RS09085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JCR18_RS09120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JCR18_RS09130	COG0133	tryptophan synthase activity
JCR18_RS09145	COG3706	GGDEF domain
JCR18_RS09160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JCR18_RS09165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JCR18_RS09170	COG0022	dehydrogenase e1 component
JCR18_RS09175	COG0508	dehydrogenase complex catalyzes the overall conversion of
JCR18_RS09180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JCR18_RS09190	COG1063	alcohol dehydrogenase
JCR18_RS09195	COG3781	membrane
JCR18_RS09205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JCR18_RS09205	COG3453	Protein conserved in bacteria
JCR18_RS09215	COG0730	response to heat
JCR18_RS09230	COG3708	Transcriptional regulator
JCR18_RS09230	COG2207	Transcriptional regulator
JCR18_RS09235	COG1733	regulation of RNA biosynthetic process
JCR18_RS09240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JCR18_RS09250	COG2188	Transcriptional regulator
JCR18_RS09265	COG4521	taurine ABC transporter
JCR18_RS09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JCR18_RS09290	COG0477	Major facilitator Superfamily
JCR18_RS09300	COG1027	Aspartate ammonia-lyase
JCR18_RS09315	COG0583	DNA-binding transcription factor activity
JCR18_RS09320	COG0583	DNA-binding transcription factor activity
JCR18_RS09325	COG0183	Belongs to the thiolase family
JCR18_RS09330	COG2031	fatty acid transporter
JCR18_RS09335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JCR18_RS09345	COG0583	DNA-binding transcription factor activity
JCR18_RS09355	COG2610	gluconate transmembrane transporter activity
JCR18_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS09370	COG2207	Transcriptional regulator
JCR18_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS09410	COG0543	2 iron, 2 sulfur cluster binding
JCR18_RS09410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JCR18_RS09415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
JCR18_RS09420	COG4638	Rieske (2fe-2S)
JCR18_RS09430	COG0725	ABC transporter, periplasmic molybdate-binding protein
JCR18_RS09435	COG4149	molybdate abc transporter
JCR18_RS09440	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JCR18_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS09450	COG3433	isochorismatase activity
JCR18_RS09450	COG1535	isochorismatase
JCR18_RS09510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JCR18_RS09525	COG0753	catalase activity
JCR18_RS09535	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
JCR18_RS09565	COG3539	Fimbrial protein
JCR18_RS09585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JCR18_RS09605	COG2072	flavoprotein involved in K transport
JCR18_RS09615	COG1538	Outer membrane efflux protein
JCR18_RS09620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JCR18_RS09625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS09630	COG0745	RESPONSE REGULATOR receiver
JCR18_RS09635	COG2205	protein histidine kinase activity
JCR18_RS09645	COG2207	Transcriptional regulator
JCR18_RS09660	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS09715	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JCR18_RS09830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JCR18_RS09850	COG1120	ATPase activity
JCR18_RS09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JCR18_RS09865	COG1064	alcohol dehydrogenase
JCR18_RS09880	COG2207	Transcriptional regulator
JCR18_RS09885	COG2084	Dehydrogenase
JCR18_RS09895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JCR18_RS09900	COG0583	DNA-binding transcription factor activity
JCR18_RS09910	COG0129	dihydroxy-acid dehydratase activity
JCR18_RS09915	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS09930	COG1566	PFAM secretion protein HlyD family protein
JCR18_RS09950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JCR18_RS09980	COG0583	DNA-binding transcription factor activity
JCR18_RS09995	COG2188	Transcriptional regulator
JCR18_RS10025	COG3210	domain, Protein
JCR18_RS10030	COG2831	hemolysin activation secretion protein
JCR18_RS10040	COG1473	amidohydrolase
JCR18_RS10050	COG0475	glutathione-regulated potassium exporter activity
JCR18_RS10050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JCR18_RS10060	COG0583	DNA-binding transcription factor activity
JCR18_RS10065	COG1335	isochorismatase
JCR18_RS10075	COG1309	transcriptional regulator
JCR18_RS10105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JCR18_RS10115	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCR18_RS10115	COG1902	pentaerythritol trinitrate reductase activity
JCR18_RS10120	COG1846	Transcriptional regulator
JCR18_RS10140	COG0753	catalase activity
JCR18_RS10155	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS10170	COG3162	membrane
JCR18_RS10180	COG3829	transcription factor binding
JCR18_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS10190	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS10210	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS10230	COG2186	Transcriptional regulator
JCR18_RS10240	COG0583	DNA-binding transcription factor activity
JCR18_RS10245	COG4948	Mandelate Racemase Muconate Lactonizing
JCR18_RS10250	COG4829	muconolactone delta-isomerase
JCR18_RS10260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JCR18_RS10265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JCR18_RS10270	COG0183	Belongs to the thiolase family
JCR18_RS10275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JCR18_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS10295	COG3733	amine oxidase
JCR18_RS10305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCR18_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS10325	COG4638	Rieske (2fe-2S)
JCR18_RS10345	COG0154	amidase activity
JCR18_RS10355	COG2814	Major facilitator Superfamily
JCR18_RS10380	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS10385	COG0583	DNA-binding transcription factor activity
JCR18_RS10390	COG1414	Transcriptional regulator
JCR18_RS10405	COG2391	methyltransferase activity
JCR18_RS10415	COG4993	Dehydrogenase
JCR18_RS10420	COG3659	wide pore channel activity
JCR18_RS10425	COG3420	alginic acid biosynthetic process
JCR18_RS10430	COG0710	3-dehydroquinate dehydratase activity
JCR18_RS10435	COG3485	protocatechuate 3,4-dioxygenase
JCR18_RS10440	COG3485	protocatechuate 3,4-dioxygenase
JCR18_RS10445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JCR18_RS10450	COG2271	Major facilitator Superfamily
JCR18_RS10455	COG0596	Alpha beta hydrolase
JCR18_RS10460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JCR18_RS10465	COG0183	Belongs to the thiolase family
JCR18_RS10470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
JCR18_RS10475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
JCR18_RS10485	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JCR18_RS10490	COG2323	membrane
JCR18_RS10535	COG1902	pentaerythritol trinitrate reductase activity
JCR18_RS10535	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCR18_RS10560	COG0542	response to heat
JCR18_RS10565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JCR18_RS10595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JCR18_RS10600	COG0569	domain protein
JCR18_RS10605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JCR18_RS10620	COG4774	siderophore transport
JCR18_RS10625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JCR18_RS10635	COG1585	Membrane protein implicated in regulation of membrane protease activity
JCR18_RS10655	COG1294	oxidase, subunit
JCR18_RS10660	COG4890	Cyd operon protein YbgT
JCR18_RS10675	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
JCR18_RS10685	COG0552	protein localization to endoplasmic reticulum
JCR18_RS10710	COG0517	IMP dehydrogenase activity
JCR18_RS10710	COG0516	GMP reductase activity
JCR18_RS10715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JCR18_RS10720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JCR18_RS10730	COG0583	DNA-binding transcription factor activity
JCR18_RS10735	COG0024	Methionine aminopeptidase
JCR18_RS10765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCR18_RS10765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JCR18_RS10770	COG1105	Belongs to the carbohydrate kinase PfkB family
JCR18_RS10775	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JCR18_RS10775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JCR18_RS10775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JCR18_RS10795	COG5001	Diguanylate cyclase
JCR18_RS10795	COG3300	MHYT domain
JCR18_RS10810	COG2135	peptidase activity
JCR18_RS10815	COG0659	secondary active sulfate transmembrane transporter activity
JCR18_RS10830	COG1113	amino acid transport
JCR18_RS10840	COG1522	sequence-specific DNA binding
JCR18_RS10865	COG1011	Hydrolase
JCR18_RS10870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JCR18_RS10880	COG2137	regulation of response to DNA damage stimulus
JCR18_RS10895	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JCR18_RS10930	COG0575	Belongs to the CDS family
JCR18_RS10935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JCR18_RS10955	COG3852	Histidine kinase
JCR18_RS10960	COG2204	response regulator
JCR18_RS11025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JCR18_RS11030	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
JCR18_RS11050	COG0697	spore germination
JCR18_RS11055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCR18_RS11065	COG0303	'Molybdopterin
JCR18_RS11070	COG0521	Mo-molybdopterin cofactor biosynthetic process
JCR18_RS11070	COG0315	cyclic pyranopterin monophosphate synthase activity
JCR18_RS11085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JCR18_RS11090	COG0243	molybdopterin cofactor binding
JCR18_RS11100	COG0243	molybdopterin cofactor binding
JCR18_RS11105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JCR18_RS11110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JCR18_RS11110	COG2146	nitrite reductase [NAD(P)H] activity
JCR18_RS11120	COG0745	RESPONSE REGULATOR receiver
JCR18_RS11125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JCR18_RS11125	COG1116	anion transmembrane transporter activity
JCR18_RS11145	COG0511	ligase activity, forming carbon-carbon bonds
JCR18_RS11160	COG2814	Major facilitator Superfamily
JCR18_RS11180	COG0069	glutamate synthase activity
JCR18_RS11200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JCR18_RS11210	COG1454	alcohol dehydrogenase
JCR18_RS11215	COG0824	Thioesterase
JCR18_RS11225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JCR18_RS11240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JCR18_RS11245	COG2030	dehydratase
JCR18_RS11255	COG0183	Belongs to the thiolase family
JCR18_RS11265	COG0583	DNA-binding transcription factor activity
JCR18_RS11270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JCR18_RS11280	COG1522	sequence-specific DNA binding
JCR18_RS11285	COG3135	benzoate transporter
JCR18_RS11295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JCR18_RS11320	COG0589	response to stress
JCR18_RS11325	COG0488	(ABC) transporter
JCR18_RS11345	COG4773	Receptor
JCR18_RS11380	COG0668	transmembrane transport
JCR18_RS11390	COG1309	transcriptional regulator
JCR18_RS11405	COG1605	Chorismate mutase
JCR18_RS11415	COG4221	oxidoreductase activity
JCR18_RS11425	COG0308	aminopeptidase N
JCR18_RS11445	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
JCR18_RS11455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JCR18_RS11460	COG1454	alcohol dehydrogenase
JCR18_RS11480	COG0531	amino acid
JCR18_RS11485	COG4303	Ethanolamine ammonia lyase large subunit
JCR18_RS11490	COG4302	ethanolamine ammonia-lyase activity
JCR18_RS11495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JCR18_RS11495	COG0519	Catalyzes the synthesis of GMP from XMP
JCR18_RS11500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JCR18_RS11510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JCR18_RS11525	COG0697	spore germination
JCR18_RS11530	COG1923	regulation of RNA biosynthetic process
JCR18_RS11540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JCR18_RS11545	COG0802	atpase or kinase
JCR18_RS11565	COG1187	pseudouridine synthase activity
JCR18_RS11580	COG0583	DNA-binding transcription factor activity
JCR18_RS11595	COG2814	Major facilitator Superfamily
JCR18_RS11600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCR18_RS11625	COG0729	surface antigen
JCR18_RS11645	COG0174	glutamine synthetase
JCR18_RS11650	COG0745	RESPONSE REGULATOR receiver
JCR18_RS11655	COG2205	protein histidine kinase activity
JCR18_RS11665	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JCR18_RS11670	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JCR18_RS11695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCR18_RS11700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JCR18_RS11705	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS11720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JCR18_RS11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JCR18_RS11745	COG0583	DNA-binding transcription factor activity
JCR18_RS11760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JCR18_RS11775	COG1215	transferase activity, transferring glycosyl groups
JCR18_RS11780	COG1649	PFAM Uncharacterised BCR, COG1649
JCR18_RS11780	COG0726	polysaccharide deacetylase
JCR18_RS11805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JCR18_RS11810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JCR18_RS11820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JCR18_RS11845	COG0305	Participates in initiation and elongation during chromosome replication
JCR18_RS11850	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JCR18_RS11860	COG1305	Transglutaminase-like
JCR18_RS11870	COG2308	Evidence 4 Homologs of previously reported genes of
JCR18_RS11900	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
JCR18_RS11905	COG0138	bifunctional purine biosynthesis protein purh
JCR18_RS11910	COG0151	Belongs to the GarS family
JCR18_RS11915	COG1464	Belongs to the NlpA lipoprotein family
JCR18_RS11920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JCR18_RS11925	COG2011	ABC-type metal ion transport system permease component
JCR18_RS11930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JCR18_RS11995	COG2433	Pfam Transposase IS66
JCR18_RS12005	COG3173	Aminoglycoside phosphotransferase
JCR18_RS12010	COG0488	(ABC) transporter
JCR18_RS12025	COG0482	sulfurtransferase activity
JCR18_RS12095	COG1794	racemase activity, acting on amino acids and derivatives
JCR18_RS12105	COG3008	intermembrane lipid transfer
JCR18_RS12105	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JCR18_RS12110	COG2995	paraquat-inducible protein a
JCR18_RS12120	COG2985	domain, Protein
JCR18_RS12145	COG0477	Major facilitator Superfamily
JCR18_RS12195	COG2186	Transcriptional regulator
JCR18_RS12205	COG0786	glutamate:sodium symporter activity
JCR18_RS12210	COG3243	poly(R)-hydroxyalkanoic acid synthase
JCR18_RS12235	COG3111	PFAM Bacterial OB fold (BOF) protein
JCR18_RS12335	COG1610	YqeY-like protein
JCR18_RS12340	COG4783	chaperone-mediated protein folding
JCR18_RS12365	COG1286	toxin biosynthetic process
JCR18_RS12395	COG0778	Nitroreductase
JCR18_RS12405	COG0513	Belongs to the DEAD box helicase family
JCR18_RS12425	COG2363	Small membrane protein
JCR18_RS12455	COG1234	tRNA 3'-trailer cleavage
JCR18_RS12460	COG2195	Cleaves the N-terminal amino acid of tripeptides
JCR18_RS12470	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JCR18_RS12480	COG2819	hydrolase of the alpha beta superfamily
JCR18_RS12485	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS12490	COG1301	dicarboxylic acid transport
JCR18_RS12495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JCR18_RS12500	COG3139	Protein of unknown function (DUF1315)
JCR18_RS12505	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JCR18_RS12510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JCR18_RS12520	COG0494	nUDIX hydrolase
JCR18_RS12530	COG0642	Histidine kinase
JCR18_RS12545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JCR18_RS12555	COG1720	tRNA m6t6A37 methyltransferase activity
JCR18_RS12570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCR18_RS12575	COG0826	peptidase U32
JCR18_RS12580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JCR18_RS12590	COG4598	ABC transporter
JCR18_RS12595	COG4160	amino acid transport
JCR18_RS12600	COG4215	(ABC) transporter
JCR18_RS12615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS12660	COG1131	(ABC) transporter
JCR18_RS12665	COG0842	Transport permease protein
JCR18_RS12680	COG0772	Belongs to the SEDS family
JCR18_RS12685	COG2951	lytic endotransglycosylase activity
JCR18_RS12710	COG2207	Transcriptional regulator
JCR18_RS12725	COG0052	Belongs to the universal ribosomal protein uS2 family
JCR18_RS12730	COG0024	Methionine aminopeptidase
JCR18_RS12740	COG2223	nitrite transmembrane transporter activity
JCR18_RS12750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JCR18_RS12755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JCR18_RS12760	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS12775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
JCR18_RS12780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JCR18_RS12785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JCR18_RS12805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JCR18_RS12810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JCR18_RS12815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JCR18_RS12850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JCR18_RS12860	COG0174	glutamine synthetase
JCR18_RS12875	COG0582	viral genome integration into host DNA
JCR18_RS12930	COG1598	PFAM Uncharacterised protein family UPF0150
JCR18_RS13405	COG5410	chromosome segregation
JCR18_RS13610	COG0512	Glutamine amidotransferase of anthranilate synthase
JCR18_RS13615	COG0308	aminopeptidase N
JCR18_RS13645	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JCR18_RS13655	COG0302	gtp cyclohydrolase
JCR18_RS13680	COG3739	integral membrane protein
JCR18_RS13695	COG1169	isochorismate synthase
JCR18_RS13720	COG1132	(ABC) transporter
JCR18_RS13725	COG1132	(ABC) transporter
JCR18_RS13740	COG1535	isochorismatase
JCR18_RS13740	COG3433	isochorismatase activity
JCR18_RS13745	COG1021	2,3-dihydroxybenzoate-AMP ligase
JCR18_RS13750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JCR18_RS13760	COG4774	siderophore transport
JCR18_RS13765	COG4607	ABC-type enterochelin transport system periplasmic component
JCR18_RS13770	COG4604	ABC transporter, ATP-binding protein
JCR18_RS13775	COG4605	iron ion homeostasis
JCR18_RS13780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JCR18_RS13785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JCR18_RS13800	COG2964	Protein conserved in bacteria
JCR18_RS13810	COG1741	Belongs to the pirin family
JCR18_RS13830	COG1309	transcriptional regulator
JCR18_RS13840	COG4948	Mandelate Racemase Muconate Lactonizing
JCR18_RS13845	COG2814	Major facilitator Superfamily
JCR18_RS13880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JCR18_RS13880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JCR18_RS13885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JCR18_RS13890	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS13900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JCR18_RS13905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JCR18_RS13910	COG0583	DNA-binding transcription factor activity
JCR18_RS13915	COG1113	amino acid transport
JCR18_RS13935	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JCR18_RS13935	COG2508	Transcriptional regulator
JCR18_RS13965	COG2879	small protein
JCR18_RS13970	COG1966	Carbon starvation protein
JCR18_RS14015	COG1067	ATP-dependent peptidase activity
JCR18_RS14020	COG0583	DNA-binding transcription factor activity
JCR18_RS14045	COG1686	Belongs to the peptidase S11 family
JCR18_RS14050	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JCR18_RS14085	COG0616	signal peptide processing
JCR18_RS14090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JCR18_RS14100	COG0573	inorganic phosphate transmembrane transporter activity
JCR18_RS14105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JCR18_RS14110	COG1113	amino acid transport
JCR18_RS14115	COG3961	Belongs to the TPP enzyme family
JCR18_RS14120	COG1522	sequence-specific DNA binding
JCR18_RS14130	COG0076	glutamate decarboxylase activity
JCR18_RS14135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JCR18_RS14145	COG1309	transcriptional regulator
JCR18_RS14160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JCR18_RS14195	COG0352	thiamine-phosphate diphosphorylase activity
JCR18_RS14220	COG0612	Peptidase, M16
JCR18_RS14230	COG1823	symporter activity
JCR18_RS14235	COG0583	DNA-binding transcription factor activity
JCR18_RS14240	COG0477	Major facilitator Superfamily
JCR18_RS14265	COG1187	pseudouridine synthase activity
JCR18_RS14280	COG1686	Belongs to the peptidase S11 family
JCR18_RS14285	COG1252	NADH dehydrogenase
JCR18_RS14295	COG0415	Belongs to the DNA photolyase family
JCR18_RS14310	COG1215	transferase activity, transferring glycosyl groups
JCR18_RS14340	COG2070	2-Nitropropane dioxygenase
JCR18_RS14395	COG0556	nucleotide-excision repair
JCR18_RS14415	COG0436	Aminotransferase
JCR18_RS14450	COG4221	oxidoreductase activity
JCR18_RS14460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JCR18_RS14465	COG1381	Involved in DNA repair and RecF pathway recombination
JCR18_RS14475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JCR18_RS14490	COG0681	Belongs to the peptidase S26 family
JCR18_RS14505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JCR18_RS14525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JCR18_RS14530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JCR18_RS14535	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
JCR18_RS14545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JCR18_RS14550	COG4208	sulfate ABC transporter
JCR18_RS14555	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JCR18_RS14560	COG0583	DNA-binding transcription factor activity
JCR18_RS14565	COG4625	pathogenesis
JCR18_RS14580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JCR18_RS14595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JCR18_RS14605	COG1051	belongs to the nudix hydrolase family
JCR18_RS14605	COG1056	cytidyltransferase-related domain
JCR18_RS14610	COG1024	Enoyl-CoA hydratase
JCR18_RS14620	COG2814	Major facilitator Superfamily
JCR18_RS14625	COG0047	phosphoribosylformylglycinamidine synthase activity
JCR18_RS14625	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JCR18_RS14645	COG1473	amidohydrolase
JCR18_RS14650	COG0824	Thioesterase
JCR18_RS14670	COG0823	Involved in the tonB-independent uptake of proteins
JCR18_RS14690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JCR18_RS14730	COG0628	permease
JCR18_RS14740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JCR18_RS14745	COG0596	Alpha beta hydrolase
JCR18_RS14750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JCR18_RS14750	COG0616	signal peptide processing
JCR18_RS14760	COG2333	competence protein COMEC
JCR18_RS14760	COG0658	competence protein
JCR18_RS14765	COG1136	(ABC) transporter
JCR18_RS14770	COG4591	ABC-type transport system involved in lipoprotein release permease component
JCR18_RS14805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS14825	COG0463	Glycosyl transferase, family 2
JCR18_RS14855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
JCR18_RS14860	COG1280	lysine exporter protein (LysE YggA)
JCR18_RS14870	COG0019	diaminopimelate decarboxylase activity
JCR18_RS14880	COG1113	amino acid transport
JCR18_RS14895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JCR18_RS14905	COG3339	Conserved Protein
JCR18_RS14910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JCR18_RS14915	COG0243	molybdopterin cofactor binding
JCR18_RS14920	COG1929	Belongs to the glycerate kinase type-1 family
JCR18_RS14935	COG0778	Nitroreductase
JCR18_RS15030	COG4397	Mu-like prophage major head subunit gpT
JCR18_RS15045	COG5005	Phage virion morphogenesis
JCR18_RS15050	COG2369	cell adhesion
JCR18_RS15055	COG4383	Mu-like prophage protein gp29
JCR18_RS15070	COG4373	Mu-like prophage FluMu protein gp28
JCR18_RS15105	COG0681	Belongs to the peptidase S26 family
JCR18_RS15135	COG3267	Type II secretory pathway component ExeA
JCR18_RS15135	COG3409	Peptidoglycan-binding domain 1 protein
JCR18_RS15210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JCR18_RS15225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JCR18_RS15245	COG0741	lytic transglycosylase activity
JCR18_RS15265	COG0584	glycerophosphoryl diester phosphodiesterase
JCR18_RS15295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JCR18_RS15300	COG1597	lipid kinase activity
JCR18_RS15315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JCR18_RS15320	COG0477	Major facilitator Superfamily
JCR18_RS15370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JCR18_RS15375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JCR18_RS15400	COG0505	Belongs to the CarA family
JCR18_RS15420	COG0589	response to stress
JCR18_RS15435	COG2843	Capsule synthesis protein
JCR18_RS15470	COG2321	neutral zinc metallopeptidase
JCR18_RS15475	COG2354	Protein conserved in bacteria
JCR18_RS15495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JCR18_RS15520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JCR18_RS15525	COG1053	succinate dehydrogenase
JCR18_RS15530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JCR18_RS15535	COG2009	succinate dehydrogenase
JCR18_RS15575	COG2921	Belongs to the UPF0250 family
JCR18_RS15580	COG0321	lipoyl(octanoyl) transferase activity
JCR18_RS15595	COG0531	amino acid
JCR18_RS15605	COG1733	regulation of RNA biosynthetic process
JCR18_RS15610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JCR18_RS15615	COG1648	precorrin-2 dehydrogenase activity
JCR18_RS15615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JCR18_RS15630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JCR18_RS15660	COG0671	phosphoesterase, PA-phosphatase related
JCR18_RS15665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS15675	COG1538	Outer membrane efflux protein
JCR18_RS15680	COG0393	Putative heavy-metal-binding
JCR18_RS15685	COG0393	Putative heavy-metal-binding
JCR18_RS15695	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS15705	COG0525	valine-tRNA ligase activity
JCR18_RS15725	COG0583	DNA-binding transcription factor activity
JCR18_RS15730	COG0004	ammonium transporteR
JCR18_RS15740	COG0642	Histidine kinase
JCR18_RS15745	COG0745	RESPONSE REGULATOR receiver
JCR18_RS15750	COG2194	sulfuric ester hydrolase activity
JCR18_RS15770	COG1752	Esterase of the alpha-beta hydrolase superfamily
JCR18_RS15785	COG2315	Protein conserved in bacteria
JCR18_RS15790	COG0142	geranyltranstransferase activity
JCR18_RS15795	COG2828	Protein conserved in bacteria
JCR18_RS15800	COG1113	amino acid transport
JCR18_RS15820	COG2207	Transcriptional regulator
JCR18_RS15845	COG2249	NAD(P)H dehydrogenase (quinone) activity
JCR18_RS15855	COG0560	Phosphoserine phosphatase
JCR18_RS15865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JCR18_RS15875	COG1530	ribonuclease E activity
JCR18_RS15880	COG0424	maF-like protein
JCR18_RS15885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JCR18_RS15890	COG1792	Involved in formation and maintenance of cell shape
JCR18_RS15895	COG1077	Cell shape determining protein MreB Mrl
JCR18_RS15900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JCR18_RS15910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JCR18_RS15940	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
JCR18_RS15945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
JCR18_RS15950	COG1752	Esterase of the alpha-beta hydrolase superfamily
JCR18_RS15955	COG1115	amino acid carrier protein
JCR18_RS15975	COG2814	Major facilitator Superfamily
JCR18_RS15980	COG1289	transmembrane transporter activity
JCR18_RS15990	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JCR18_RS16030	COG1376	ErfK ybiS ycfS ynhG family protein
JCR18_RS16035	COG2832	Protein of unknown function (DUF454)
JCR18_RS16045	COG5510	response to toxic substance
JCR18_RS16065	COG0840	transmembrane signaling receptor activity
JCR18_RS16105	COG3422	double-strand break repair
JCR18_RS16110	COG2824	Alkylphosphonate utilization operon protein PhnA
JCR18_RS16115	COG3189	MarR family transcriptional regulator
JCR18_RS16125	COG0354	folic acid binding
JCR18_RS16130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JCR18_RS16140	COG0679	Auxin Efflux Carrier
JCR18_RS16145	COG1902	pentaerythritol trinitrate reductase activity
JCR18_RS16160	COG4772	TonB-dependent receptor
JCR18_RS16165	COG2094	Belongs to the DNA glycosylase MPG family
JCR18_RS16190	COG1217	gtp-binding protein TYPA
JCR18_RS16195	COG2233	PERMEase
JCR18_RS16205	COG0833	amino acid
JCR18_RS16210	COG1690	Belongs to the RtcB family
JCR18_RS16220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JCR18_RS16220	COG2885	chlorophyll binding
JCR18_RS16230	COG0183	Belongs to the thiolase family
JCR18_RS16250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JCR18_RS16270	COG2207	Transcriptional regulator
JCR18_RS16275	COG0183	Belongs to the thiolase family
JCR18_RS16305	COG1272	protein, Hemolysin III
JCR18_RS16310	COG0477	Major facilitator Superfamily
JCR18_RS16325	COG0450	alkyl hydroperoxide reductase
JCR18_RS16345	COG0285	dihydrofolate synthase activity
JCR18_RS16395	COG2096	Adenosyltransferase
JCR18_RS16415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
JCR18_RS16420	COG0745	RESPONSE REGULATOR receiver
JCR18_RS16425	COG2205	protein histidine kinase activity
JCR18_RS16435	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS16440	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS16445	COG0583	DNA-binding transcription factor activity
JCR18_RS16450	COG0625	glutathione transferase activity
JCR18_RS16515	COG0438	transferase activity, transferring glycosyl groups
JCR18_RS16520	COG0463	Glycosyl transferase, family 2
JCR18_RS16525	COG0726	polysaccharide deacetylase
JCR18_RS16545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JCR18_RS16550	COG2205	protein histidine kinase activity
JCR18_RS16580	COG1862	Preprotein translocase
JCR18_RS16590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JCR18_RS16595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JCR18_RS16605	COG3781	membrane
JCR18_RS16610	COG0613	PHP domain protein
JCR18_RS16620	COG2350	Protein conserved in bacteria
JCR18_RS16650	COG1607	acyl-coa hydrolase
JCR18_RS16710	COG2199	diguanylate cyclase activity
JCR18_RS16720	COG1408	metallophosphoesterase
JCR18_RS16725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JCR18_RS16735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JCR18_RS16755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JCR18_RS16760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JCR18_RS16775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JCR18_RS16785	COG2969	positive regulation of protein catabolic process
JCR18_RS16805	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS16810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
JCR18_RS16825	COG1309	transcriptional regulator
JCR18_RS16830	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS16875	COG1183	phosphatidylcholine synthase activity
JCR18_RS16880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JCR18_RS16910	COG0741	lytic transglycosylase activity
JCR18_RS16910	COG0739	heme binding
JCR18_RS16910	COG1196	nuclear chromosome segregation
JCR18_RS16920	COG1702	phosphate starvation-inducible protein PhoH
JCR18_RS16955	COG1295	ribonuclease BN
JCR18_RS16960	COG0697	spore germination
JCR18_RS16965	COG2169	Transcriptional regulator
JCR18_RS16970	COG0179	Fumarylacetoacetate (FAA) hydrolase
JCR18_RS17015	COG0557	exoribonuclease II activity
JCR18_RS17020	COG0339	signal peptide processing
JCR18_RS17025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JCR18_RS17055	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
JCR18_RS17060	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS17215	COG0626	cystathionine gamma-synthase activity
JCR18_RS17220	COG0433	COG0433 Predicted ATPase
JCR18_RS17225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JCR18_RS17225	COG1017	nitric oxide dioxygenase activity
JCR18_RS17230	COG1959	2 iron, 2 sulfur cluster binding
JCR18_RS17245	COG1301	dicarboxylic acid transport
JCR18_RS17250	COG1946	Acyl-CoA thioesterase
JCR18_RS17270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JCR18_RS17275	COG1040	competence protein
JCR18_RS17280	COG0494	nUDIX hydrolase
JCR18_RS17290	COG0598	Magnesium transport protein CorA
JCR18_RS17300	COG2854	intermembrane phospholipid transfer
JCR18_RS17310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JCR18_RS17315	COG1127	ABC transporter
JCR18_RS17325	COG0513	Belongs to the DEAD box helicase family
JCR18_RS17345	COG0408	coproporphyrinogen oxidase activity
JCR18_RS17360	COG1960	acyl-CoA dehydrogenase activity
JCR18_RS17370	COG1983	PspC domain protein
JCR18_RS17375	COG0517	IMP dehydrogenase activity
JCR18_RS17420	COG0583	DNA-binding transcription factor activity
JCR18_RS17460	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS17470	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JCR18_RS17475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JCR18_RS17480	COG0833	amino acid
JCR18_RS17510	COG1192	Involved in chromosome partitioning
JCR18_RS17515	COG0628	permease
JCR18_RS17525	COG1289	transmembrane transporter activity
JCR18_RS17540	COG2249	NAD(P)H dehydrogenase (quinone) activity
JCR18_RS17545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JCR18_RS17555	COG0277	FAD linked oxidase domain protein
JCR18_RS17560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JCR18_RS17585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JCR18_RS17590	COG5380	lipid catabolic process
JCR18_RS17610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JCR18_RS17660	COG0194	GDP metabolic process
JCR18_RS17675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JCR18_RS17695	COG3307	-O-antigen
JCR18_RS17715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
JCR18_RS17720	COG1704	LemA family
JCR18_RS17730	COG0493	'glutamate synthase
JCR18_RS17735	COG0070	glutamate synthase
JCR18_RS17735	COG0069	glutamate synthase activity
JCR18_RS17735	COG0067	glutamate synthase
JCR18_RS17785	COG2226	methyltransferase
JCR18_RS17800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JCR18_RS17805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JCR18_RS17850	COG0833	amino acid
JCR18_RS17935	COG0488	(ABC) transporter
JCR18_RS17940	COG2873	o-acetylhomoserine
JCR18_RS17945	COG4221	oxidoreductase activity
JCR18_RS17950	COG0659	secondary active sulfate transmembrane transporter activity
JCR18_RS17975	COG0427	acetyl-CoA hydrolase
JCR18_RS18005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
JCR18_RS18035	COG2329	Antibiotic biosynthesis monooxygenase
JCR18_RS18050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JCR18_RS18115	COG2249	NAD(P)H dehydrogenase (quinone) activity
JCR18_RS18120	COG1733	regulation of RNA biosynthetic process
JCR18_RS18155	COG0667	Aldo Keto reductase
JCR18_RS18175	COG0583	DNA-binding transcription factor activity
JCR18_RS18180	COG2814	Major facilitator Superfamily
JCR18_RS18210	COG1335	isochorismatase
JCR18_RS18220	COG1012	belongs to the aldehyde dehydrogenase family
JCR18_RS18225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JCR18_RS18235	COG1113	amino acid transport
JCR18_RS18245	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JCR18_RS18260	COG2814	Major facilitator Superfamily
JCR18_RS18270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JCR18_RS18270	COG0352	thiamine-phosphate diphosphorylase activity
JCR18_RS18270	COG0351	phosphomethylpyrimidine kinase
JCR18_RS18290	COG1309	transcriptional regulator
JCR18_RS18295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JCR18_RS18315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JCR18_RS18325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JCR18_RS18330	COG3162	membrane
JCR18_RS18335	COG0784	Response regulator, receiver
JCR18_RS18335	COG2198	Histidine kinase
JCR18_RS18335	COG2205	protein histidine kinase activity
JCR18_RS18360	COG3328	transposase activity
JCR18_RS18365	COG1522	sequence-specific DNA binding
JCR18_RS18370	COG1335	isochorismatase
JCR18_RS18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JCR18_RS18385	COG0668	transmembrane transport
JCR18_RS18390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JCR18_RS18395	COG1519	Transferase
JCR18_RS18400	COG1902	pentaerythritol trinitrate reductase activity
JCR18_RS18420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JCR18_RS18445	COG0426	domain, Protein
JCR18_RS18445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCR18_RS18450	COG4774	siderophore transport
JCR18_RS18455	COG2119	membrane
JCR18_RS18465	COG0508	dehydrogenase complex catalyzes the overall conversion of
JCR18_RS18475	COG4942	peptidase
JCR18_RS18490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JCR18_RS18500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JCR18_RS18520	COG0189	ligase activity
JCR18_RS18540	COG0708	Exodeoxyribonuclease III
JCR18_RS18545	COG1393	Belongs to the ArsC family
JCR18_RS18560	COG3706	GGDEF domain
JCR18_RS18595	COG2351	hydroxyisourate hydrolase activity
JCR18_RS18600	COG2233	PERMEase
JCR18_RS18610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JCR18_RS18620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
JCR18_RS18625	COG1028	Short-chain dehydrogenase reductase Sdr
JCR18_RS18635	COG3150	esterase
JCR18_RS18650	COG0791	NLP P60 protein
JCR18_RS18650	COG1388	LysM domain
JCR18_RS18665	COG2918	glutathione biosynthetic process
JCR18_RS18680	COG2733	membrane
JCR18_RS18685	COG0436	Aminotransferase
JCR18_RS18690	COG0534	Mate efflux family protein
JCR18_RS18790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JCR18_RS18795	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JCR18_RS18805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JCR18_RS18810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JCR18_RS18825	COG0010	Belongs to the arginase family
JCR18_RS18855	COG2188	Transcriptional regulator
JCR18_RS18865	COG0523	cobalamin synthesis protein
JCR18_RS18875	COG1113	amino acid transport
JCR18_RS18885	COG0625	glutathione transferase activity
JCR18_RS18905	COG1683	Conserved Protein
JCR18_RS18910	COG0534	Mate efflux family protein
JCR18_RS18915	COG0385	Bile acid
JCR18_RS18920	COG1335	isochorismatase
JCR18_RS18925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JCR18_RS18945	COG2116	formate transmembrane transporter activity
JCR18_RS18950	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JCR18_RS18955	COG2133	pyrroloquinoline quinone binding
JCR18_RS18960	COG2983	Belongs to the UPF0260 family
JCR18_RS18980	COG1194	a g-specific adenine glycosylase
JCR18_RS18995	COG2818	Glycosylase
JCR18_RS19000	COG1064	alcohol dehydrogenase
JCR18_RS19005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCR18_RS19020	COG0583	DNA-binding transcription factor activity
JCR18_RS19025	COG0656	L-ascorbic acid biosynthetic process
JCR18_RS19030	COG2814	Major facilitator Superfamily
JCR18_RS19065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JCR18_RS19080	COG2233	PERMEase
JCR18_RS19170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JCR18_RS19175	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JCR18_RS19180	COG0596	Alpha beta hydrolase
JCR18_RS19205	COG0488	(ABC) transporter
JCR18_RS19210	COG0586	Pfam SNARE associated Golgi protein
JCR18_RS19220	COG0187	DNA topoisomerase II activity
JCR18_RS19230	COG0592	DNA-directed DNA polymerase activity
JCR18_RS19315	COG0484	heat shock protein binding
JCR18_RS19405	COG0741	lytic transglycosylase activity
JCR18_RS19440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JCR18_RS19610	COG1525	nuclease
JCR18_RS19680	COG1475	DNA binding
JCR18_RS19700	COG3853	Toxic anion resistance protein (TelA)