locus-tag	class	description
B7L46_RS00030	COG0482	sulfurtransferase activity
B7L46_RS00045	COG0488	(ABC) transporter
B7L46_RS00050	COG3173	Aminoglycoside phosphotransferase
B7L46_RS00110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L46_RS00155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L46_RS00185	COG0659	secondary active sulfate transmembrane transporter activity
B7L46_RS00190	COG0589	response to stress
B7L46_RS00240	COG0501	Belongs to the peptidase M48B family
B7L46_RS00435	COG0739	heme binding
B7L46_RS00470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L46_RS00485	COG1192	Involved in chromosome partitioning
B7L46_RS00535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L46_RS00610	COG1660	Displays ATPase and GTPase activities
B7L46_RS00680	COG1373	ATPase (AAA superfamily
B7L46_RS00735	COG0659	secondary active sulfate transmembrane transporter activity
B7L46_RS00740	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B7L46_RS00870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L46_RS00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L46_RS00925	COG1192	Involved in chromosome partitioning
B7L46_RS01040	COG1132	(ABC) transporter
B7L46_RS01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B7L46_RS01085	COG2030	dehydratase
B7L46_RS01095	COG0183	Belongs to the thiolase family
B7L46_RS01105	COG0583	DNA-binding transcription factor activity
B7L46_RS01110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L46_RS01120	COG1522	sequence-specific DNA binding
B7L46_RS01125	COG3135	benzoate transporter
B7L46_RS01135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B7L46_RS01150	COG0589	response to stress
B7L46_RS01155	COG0488	(ABC) transporter
B7L46_RS01175	COG4773	Receptor
B7L46_RS01205	COG0668	transmembrane transport
B7L46_RS01255	COG0583	DNA-binding transcription factor activity
B7L46_RS01260	COG2814	Major facilitator Superfamily
B7L46_RS01265	COG2814	Major facilitator Superfamily
B7L46_RS01270	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L46_RS01275	COG3384	dioxygenase
B7L46_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS01290	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B7L46_RS01295	COG4638	Rieske (2fe-2S)
B7L46_RS01300	COG0583	DNA-binding transcription factor activity
B7L46_RS01320	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B7L46_RS01325	COG3971	2-oxopent-4-enoate hydratase activity
B7L46_RS01335	COG2271	Major facilitator Superfamily
B7L46_RS01340	COG1234	tRNA 3'-trailer cleavage
B7L46_RS01375	COG1538	Outer membrane efflux protein
B7L46_RS01390	COG2885	chlorophyll binding
B7L46_RS01390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B7L46_RS01440	COG1605	Chorismate mutase
B7L46_RS01460	COG0308	aminopeptidase N
B7L46_RS01480	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B7L46_RS01490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B7L46_RS01495	COG1454	alcohol dehydrogenase
B7L46_RS01515	COG0531	amino acid
B7L46_RS01520	COG4303	Ethanolamine ammonia lyase large subunit
B7L46_RS01525	COG4302	ethanolamine ammonia-lyase activity
B7L46_RS01530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L46_RS01530	COG0519	Catalyzes the synthesis of GMP from XMP
B7L46_RS01535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L46_RS01560	COG0697	spore germination
B7L46_RS01565	COG1923	regulation of RNA biosynthetic process
B7L46_RS01575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L46_RS01580	COG0802	atpase or kinase
B7L46_RS01600	COG1187	pseudouridine synthase activity
B7L46_RS01620	COG0583	DNA-binding transcription factor activity
B7L46_RS01640	COG2814	Major facilitator Superfamily
B7L46_RS01645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L46_RS01675	COG0729	surface antigen
B7L46_RS01695	COG0174	glutamine synthetase
B7L46_RS01700	COG0745	RESPONSE REGULATOR receiver
B7L46_RS01705	COG2205	protein histidine kinase activity
B7L46_RS01715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B7L46_RS01720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B7L46_RS01745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS01750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L46_RS01755	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS01785	COG0583	DNA-binding transcription factor activity
B7L46_RS01805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS01815	COG3658	cytochrome
B7L46_RS01820	COG1215	transferase activity, transferring glycosyl groups
B7L46_RS01825	COG1649	PFAM Uncharacterised BCR, COG1649
B7L46_RS01825	COG0726	polysaccharide deacetylase
B7L46_RS01850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B7L46_RS01855	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B7L46_RS01865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B7L46_RS01890	COG0305	Participates in initiation and elongation during chromosome replication
B7L46_RS01895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L46_RS01905	COG1305	Transglutaminase-like
B7L46_RS01915	COG2308	Evidence 4 Homologs of previously reported genes of
B7L46_RS01945	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B7L46_RS01950	COG0138	bifunctional purine biosynthesis protein purh
B7L46_RS01955	COG0151	Belongs to the GarS family
B7L46_RS01960	COG1464	Belongs to the NlpA lipoprotein family
B7L46_RS01965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L46_RS01970	COG2011	ABC-type metal ion transport system permease component
B7L46_RS01975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L46_RS01985	COG1301	dicarboxylic acid transport
B7L46_RS02010	COG2814	Major facilitator Superfamily
B7L46_RS02025	COG1309	transcriptional regulator
B7L46_RS02050	COG1794	racemase activity, acting on amino acids and derivatives
B7L46_RS02055	COG0492	ferredoxin-NADP+ reductase activity
B7L46_RS02055	COG3118	belongs to the thioredoxin family
B7L46_RS02070	COG3008	intermembrane lipid transfer
B7L46_RS02070	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B7L46_RS02075	COG2995	paraquat-inducible protein a
B7L46_RS02115	COG1051	belongs to the nudix hydrolase family
B7L46_RS02120	COG0477	Major facilitator Superfamily
B7L46_RS02175	COG2186	Transcriptional regulator
B7L46_RS02185	COG0786	glutamate:sodium symporter activity
B7L46_RS02190	COG3243	poly(R)-hydroxyalkanoic acid synthase
B7L46_RS02215	COG3111	PFAM Bacterial OB fold (BOF) protein
B7L46_RS02225	COG2226	methyltransferase
B7L46_RS02310	COG3210	domain, Protein
B7L46_RS02310	COG3210	domain, Protein
B7L46_RS02315	COG2831	hemolysin activation secretion protein
B7L46_RS02340	COG2815	serine threonine protein kinase
B7L46_RS02340	COG0515	serine threonine protein kinase
B7L46_RS02370	COG1610	YqeY-like protein
B7L46_RS02375	COG4783	chaperone-mediated protein folding
B7L46_RS02400	COG1286	toxin biosynthetic process
B7L46_RS02425	COG3179	chitinase
B7L46_RS02580	COG5410	chromosome segregation
B7L46_RS02680	COG0305	Participates in initiation and elongation during chromosome replication
B7L46_RS02800	COG0778	Nitroreductase
B7L46_RS02810	COG0513	Belongs to the DEAD box helicase family
B7L46_RS02830	COG2363	Small membrane protein
B7L46_RS02860	COG4650	regulator
B7L46_RS02865	COG1234	tRNA 3'-trailer cleavage
B7L46_RS02870	COG1690	Belongs to the RtcB family
B7L46_RS02890	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7L46_RS02900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L46_RS02910	COG2819	hydrolase of the alpha beta superfamily
B7L46_RS02915	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS02920	COG1301	dicarboxylic acid transport
B7L46_RS02930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L46_RS02935	COG3139	Protein of unknown function (DUF1315)
B7L46_RS02940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L46_RS02945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L46_RS02955	COG0494	nUDIX hydrolase
B7L46_RS02965	COG0642	Histidine kinase
B7L46_RS02980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B7L46_RS02990	COG1720	tRNA m6t6A37 methyltransferase activity
B7L46_RS03005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L46_RS03010	COG0826	peptidase U32
B7L46_RS03015	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L46_RS03025	COG4598	ABC transporter
B7L46_RS03030	COG4160	amino acid transport
B7L46_RS03035	COG4215	(ABC) transporter
B7L46_RS03050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS03270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L46_RS03330	COG0582	viral genome integration into host DNA
B7L46_RS03335	COG1131	(ABC) transporter
B7L46_RS03340	COG0842	Transport permease protein
B7L46_RS03355	COG0772	Belongs to the SEDS family
B7L46_RS03360	COG2951	lytic endotransglycosylase activity
B7L46_RS03385	COG2207	Transcriptional regulator
B7L46_RS03400	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L46_RS03405	COG0024	Methionine aminopeptidase
B7L46_RS03415	COG2223	nitrite transmembrane transporter activity
B7L46_RS03425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L46_RS03430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L46_RS03435	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS03450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L46_RS03455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L46_RS03460	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L46_RS03480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L46_RS03485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B7L46_RS03490	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B7L46_RS03525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B7L46_RS03535	COG0174	glutamine synthetase
B7L46_RS03550	COG0512	Glutamine amidotransferase of anthranilate synthase
B7L46_RS03575	COG2840	Smr protein MutS2
B7L46_RS03585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L46_RS03595	COG0302	gtp cyclohydrolase
B7L46_RS03615	COG3739	integral membrane protein
B7L46_RS03630	COG1169	isochorismate synthase
B7L46_RS03635	COG2977	Belongs to the P-Pant transferase superfamily
B7L46_RS03640	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B7L46_RS03645	COG1132	(ABC) transporter
B7L46_RS03650	COG1132	(ABC) transporter
B7L46_RS03660	COG1535	isochorismatase
B7L46_RS03660	COG3433	isochorismatase activity
B7L46_RS03665	COG1021	2,3-dihydroxybenzoate-AMP ligase
B7L46_RS03670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L46_RS03680	COG4774	siderophore transport
B7L46_RS03685	COG4607	ABC-type enterochelin transport system periplasmic component
B7L46_RS03690	COG4604	ABC transporter, ATP-binding protein
B7L46_RS03695	COG4605	iron ion homeostasis
B7L46_RS03700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L46_RS03705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L46_RS03720	COG2964	Protein conserved in bacteria
B7L46_RS03730	COG1741	Belongs to the pirin family
B7L46_RS03775	COG2879	small protein
B7L46_RS03780	COG1966	Carbon starvation protein
B7L46_RS03800	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B7L46_RS03820	COG2211	Major facilitator Superfamily
B7L46_RS03825	COG1067	ATP-dependent peptidase activity
B7L46_RS03830	COG0583	DNA-binding transcription factor activity
B7L46_RS03855	COG1686	Belongs to the peptidase S11 family
B7L46_RS03860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B7L46_RS03895	COG0616	signal peptide processing
B7L46_RS03900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B7L46_RS03910	COG0573	inorganic phosphate transmembrane transporter activity
B7L46_RS03915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B7L46_RS03920	COG1113	amino acid transport
B7L46_RS03925	COG3961	Belongs to the TPP enzyme family
B7L46_RS03930	COG1522	sequence-specific DNA binding
B7L46_RS03940	COG0076	glutamate decarboxylase activity
B7L46_RS03945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B7L46_RS03955	COG1309	transcriptional regulator
B7L46_RS03970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B7L46_RS04005	COG0352	thiamine-phosphate diphosphorylase activity
B7L46_RS04030	COG1203	CRISPR-associated helicase, Cas3
B7L46_RS04060	COG0612	Peptidase, M16
B7L46_RS04070	COG1823	symporter activity
B7L46_RS04075	COG0583	DNA-binding transcription factor activity
B7L46_RS04080	COG0477	Major facilitator Superfamily
B7L46_RS04100	COG1187	pseudouridine synthase activity
B7L46_RS04115	COG1686	Belongs to the peptidase S11 family
B7L46_RS04120	COG1252	NADH dehydrogenase
B7L46_RS04130	COG0415	Belongs to the DNA photolyase family
B7L46_RS04145	COG1215	transferase activity, transferring glycosyl groups
B7L46_RS04175	COG2070	2-Nitropropane dioxygenase
B7L46_RS04230	COG0556	nucleotide-excision repair
B7L46_RS04250	COG0436	Aminotransferase
B7L46_RS04275	COG4221	oxidoreductase activity
B7L46_RS04285	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B7L46_RS04290	COG1381	Involved in DNA repair and RecF pathway recombination
B7L46_RS04300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L46_RS04315	COG0681	Belongs to the peptidase S26 family
B7L46_RS04330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L46_RS04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B7L46_RS04355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L46_RS04360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B7L46_RS04370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B7L46_RS04375	COG4208	sulfate ABC transporter
B7L46_RS04380	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B7L46_RS04385	COG0583	DNA-binding transcription factor activity
B7L46_RS04390	COG4625	pathogenesis
B7L46_RS04405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L46_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B7L46_RS04430	COG1051	belongs to the nudix hydrolase family
B7L46_RS04430	COG1056	cytidyltransferase-related domain
B7L46_RS04435	COG1024	Enoyl-CoA hydratase
B7L46_RS04445	COG2814	Major facilitator Superfamily
B7L46_RS04450	COG0047	phosphoribosylformylglycinamidine synthase activity
B7L46_RS04450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L46_RS04470	COG1473	amidohydrolase
B7L46_RS04475	COG0824	Thioesterase
B7L46_RS04495	COG0823	Involved in the tonB-independent uptake of proteins
B7L46_RS04515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L46_RS04550	COG0628	permease
B7L46_RS04560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L46_RS04565	COG0596	Alpha beta hydrolase
B7L46_RS04570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B7L46_RS04570	COG0616	signal peptide processing
B7L46_RS04580	COG0658	competence protein
B7L46_RS04580	COG2333	competence protein COMEC
B7L46_RS04585	COG1136	(ABC) transporter
B7L46_RS04590	COG4591	ABC-type transport system involved in lipoprotein release permease component
B7L46_RS04620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS04640	COG0463	Glycosyl transferase, family 2
B7L46_RS04680	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B7L46_RS04685	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS04695	COG0019	diaminopimelate decarboxylase activity
B7L46_RS04705	COG1113	amino acid transport
B7L46_RS04720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B7L46_RS04730	COG3339	Conserved Protein
B7L46_RS04735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B7L46_RS04740	COG0243	molybdopterin cofactor binding
B7L46_RS04745	COG1929	Belongs to the glycerate kinase type-1 family
B7L46_RS04760	COG0778	Nitroreductase
B7L46_RS04795	COG3811	Belongs to the UPF0386 family
B7L46_RS04805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L46_RS04820	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L46_RS04845	COG0741	lytic transglycosylase activity
B7L46_RS04865	COG0584	glycerophosphoryl diester phosphodiesterase
B7L46_RS04890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B7L46_RS04895	COG1597	lipid kinase activity
B7L46_RS04910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B7L46_RS04915	COG0477	Major facilitator Superfamily
B7L46_RS04965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L46_RS04970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L46_RS05000	COG0505	Belongs to the CarA family
B7L46_RS05020	COG0589	response to stress
B7L46_RS05035	COG2843	Capsule synthesis protein
B7L46_RS05055	COG2321	neutral zinc metallopeptidase
B7L46_RS05060	COG2354	Protein conserved in bacteria
B7L46_RS05080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L46_RS05100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L46_RS05105	COG1053	succinate dehydrogenase
B7L46_RS05110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B7L46_RS05115	COG2009	succinate dehydrogenase
B7L46_RS05150	COG2921	Belongs to the UPF0250 family
B7L46_RS05155	COG0321	lipoyl(octanoyl) transferase activity
B7L46_RS05170	COG0531	amino acid
B7L46_RS05180	COG1733	regulation of RNA biosynthetic process
B7L46_RS05185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L46_RS05190	COG1648	precorrin-2 dehydrogenase activity
B7L46_RS05190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L46_RS05205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B7L46_RS05235	COG0671	phosphoesterase, PA-phosphatase related
B7L46_RS05240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS05250	COG1538	Outer membrane efflux protein
B7L46_RS05255	COG0393	Putative heavy-metal-binding
B7L46_RS05260	COG0393	Putative heavy-metal-binding
B7L46_RS05270	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS05280	COG0525	valine-tRNA ligase activity
B7L46_RS05300	COG0583	DNA-binding transcription factor activity
B7L46_RS05310	COG0004	ammonium transporteR
B7L46_RS05320	COG0642	Histidine kinase
B7L46_RS05325	COG0745	RESPONSE REGULATOR receiver
B7L46_RS05330	COG2194	sulfuric ester hydrolase activity
B7L46_RS05350	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L46_RS05365	COG2315	Protein conserved in bacteria
B7L46_RS05370	COG0142	geranyltranstransferase activity
B7L46_RS05375	COG2828	Protein conserved in bacteria
B7L46_RS05380	COG1113	amino acid transport
B7L46_RS05400	COG2207	Transcriptional regulator
B7L46_RS05425	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L46_RS05435	COG0560	Phosphoserine phosphatase
B7L46_RS05445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B7L46_RS05450	COG1530	ribonuclease E activity
B7L46_RS05455	COG0424	maF-like protein
B7L46_RS05460	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B7L46_RS05465	COG1792	Involved in formation and maintenance of cell shape
B7L46_RS05470	COG1077	Cell shape determining protein MreB Mrl
B7L46_RS05475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L46_RS05485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L46_RS05510	COG3590	peptidase
B7L46_RS05515	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
B7L46_RS05520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L46_RS05525	COG1752	Esterase of the alpha-beta hydrolase superfamily
B7L46_RS05530	COG1115	amino acid carrier protein
B7L46_RS05545	COG2814	Major facilitator Superfamily
B7L46_RS05550	COG1289	transmembrane transporter activity
B7L46_RS05560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B7L46_RS05600	COG1376	ErfK ybiS ycfS ynhG family protein
B7L46_RS05605	COG2832	Protein of unknown function (DUF454)
B7L46_RS05615	COG5510	response to toxic substance
B7L46_RS05635	COG0840	transmembrane signaling receptor activity
B7L46_RS05675	COG3422	double-strand break repair
B7L46_RS05680	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L46_RS05685	COG3189	MarR family transcriptional regulator
B7L46_RS05705	COG0354	folic acid binding
B7L46_RS05710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L46_RS05725	COG1902	pentaerythritol trinitrate reductase activity
B7L46_RS05730	COG4772	TonB-dependent receptor
B7L46_RS05745	COG2094	Belongs to the DNA glycosylase MPG family
B7L46_RS05770	COG1217	gtp-binding protein TYPA
B7L46_RS05775	COG2233	PERMEase
B7L46_RS05785	COG0833	amino acid
B7L46_RS05790	COG1690	Belongs to the RtcB family
B7L46_RS05795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B7L46_RS05795	COG2885	chlorophyll binding
B7L46_RS05805	COG0183	Belongs to the thiolase family
B7L46_RS05825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L46_RS05845	COG2207	Transcriptional regulator
B7L46_RS05850	COG0183	Belongs to the thiolase family
B7L46_RS05880	COG1272	protein, Hemolysin III
B7L46_RS05885	COG0477	Major facilitator Superfamily
B7L46_RS05900	COG0450	alkyl hydroperoxide reductase
B7L46_RS05920	COG0285	dihydrofolate synthase activity
B7L46_RS05970	COG2096	Adenosyltransferase
B7L46_RS05975	COG0584	glycerophosphoryl diester phosphodiesterase
B7L46_RS05990	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B7L46_RS05995	COG0745	RESPONSE REGULATOR receiver
B7L46_RS06000	COG2205	protein histidine kinase activity
B7L46_RS06010	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS06015	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS06070	COG1442	glycosyl transferase family 8
B7L46_RS06085	COG0438	transferase activity, transferring glycosyl groups
B7L46_RS06095	COG0438	transferase activity, transferring glycosyl groups
B7L46_RS06100	COG0726	polysaccharide deacetylase
B7L46_RS06115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B7L46_RS06120	COG2205	protein histidine kinase activity
B7L46_RS06150	COG1862	Preprotein translocase
B7L46_RS06160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L46_RS06165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L46_RS06175	COG3781	membrane
B7L46_RS06180	COG0613	PHP domain protein
B7L46_RS06190	COG2350	Protein conserved in bacteria
B7L46_RS06220	COG1607	acyl-coa hydrolase
B7L46_RS06280	COG2199	diguanylate cyclase activity
B7L46_RS06290	COG1408	metallophosphoesterase
B7L46_RS06295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L46_RS06305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B7L46_RS06325	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B7L46_RS06330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L46_RS06335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B7L46_RS06345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L46_RS06355	COG2969	positive regulation of protein catabolic process
B7L46_RS06375	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS06380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L46_RS06395	COG1309	transcriptional regulator
B7L46_RS06445	COG1183	phosphatidylcholine synthase activity
B7L46_RS06450	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B7L46_RS06480	COG1196	nuclear chromosome segregation
B7L46_RS06480	COG0739	heme binding
B7L46_RS06480	COG0741	lytic transglycosylase activity
B7L46_RS06490	COG1702	phosphate starvation-inducible protein PhoH
B7L46_RS06525	COG1295	ribonuclease BN
B7L46_RS06530	COG0697	spore germination
B7L46_RS06535	COG2169	Transcriptional regulator
B7L46_RS06540	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L46_RS06585	COG0557	exoribonuclease II activity
B7L46_RS06590	COG0339	signal peptide processing
B7L46_RS06595	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B7L46_RS06625	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B7L46_RS06630	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS06785	COG0626	cystathionine gamma-synthase activity
B7L46_RS06790	COG0433	COG0433 Predicted ATPase
B7L46_RS06795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B7L46_RS06795	COG1017	nitric oxide dioxygenase activity
B7L46_RS06800	COG1959	2 iron, 2 sulfur cluster binding
B7L46_RS06815	COG1301	dicarboxylic acid transport
B7L46_RS06820	COG1946	Acyl-CoA thioesterase
B7L46_RS06840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L46_RS06845	COG1040	competence protein
B7L46_RS06850	COG0494	nUDIX hydrolase
B7L46_RS06860	COG0598	Magnesium transport protein CorA
B7L46_RS06870	COG2854	intermembrane phospholipid transfer
B7L46_RS06880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L46_RS06885	COG1127	ABC transporter
B7L46_RS06890	COG0513	Belongs to the DEAD box helicase family
B7L46_RS06910	COG0408	coproporphyrinogen oxidase activity
B7L46_RS06925	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS06935	COG1983	PspC domain protein
B7L46_RS06940	COG0517	IMP dehydrogenase activity
B7L46_RS06975	COG1106	Psort location Cytoplasmic, score
B7L46_RS06995	COG0583	DNA-binding transcription factor activity
B7L46_RS07035	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS07045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L46_RS07050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B7L46_RS07055	COG0833	amino acid
B7L46_RS07085	COG1192	Involved in chromosome partitioning
B7L46_RS07090	COG0628	permease
B7L46_RS07100	COG1289	transmembrane transporter activity
B7L46_RS07115	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L46_RS07120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B7L46_RS07130	COG0277	FAD linked oxidase domain protein
B7L46_RS07135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B7L46_RS07160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B7L46_RS07185	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L46_RS07235	COG0194	GDP metabolic process
B7L46_RS07245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L46_RS07265	COG3307	-O-antigen
B7L46_RS07280	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B7L46_RS07285	COG1704	LemA family
B7L46_RS07295	COG0493	'glutamate synthase
B7L46_RS07300	COG0070	glutamate synthase
B7L46_RS07300	COG0069	glutamate synthase activity
B7L46_RS07300	COG0067	glutamate synthase
B7L46_RS07350	COG2226	methyltransferase
B7L46_RS07365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L46_RS07370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L46_RS07415	COG0833	amino acid
B7L46_RS07495	COG0488	(ABC) transporter
B7L46_RS07505	COG4221	oxidoreductase activity
B7L46_RS07510	COG0659	secondary active sulfate transmembrane transporter activity
B7L46_RS07530	COG0427	acetyl-CoA hydrolase
B7L46_RS07560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L46_RS07595	COG2329	Antibiotic biosynthesis monooxygenase
B7L46_RS07610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B7L46_RS07690	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L46_RS07700	COG1733	regulation of RNA biosynthetic process
B7L46_RS07730	COG1733	regulation of RNA biosynthetic process
B7L46_RS07755	COG0667	Aldo Keto reductase
B7L46_RS07775	COG0583	DNA-binding transcription factor activity
B7L46_RS07780	COG2814	Major facilitator Superfamily
B7L46_RS07810	COG1335	isochorismatase
B7L46_RS07820	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS07825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B7L46_RS07835	COG1113	amino acid transport
B7L46_RS07845	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B7L46_RS07860	COG2814	Major facilitator Superfamily
B7L46_RS07870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B7L46_RS07870	COG0352	thiamine-phosphate diphosphorylase activity
B7L46_RS07870	COG0351	phosphomethylpyrimidine kinase
B7L46_RS07890	COG1309	transcriptional regulator
B7L46_RS07910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L46_RS07920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L46_RS07925	COG3162	membrane
B7L46_RS07930	COG0784	Response regulator, receiver
B7L46_RS07930	COG2198	Histidine kinase
B7L46_RS07930	COG2205	protein histidine kinase activity
B7L46_RS07955	COG1522	sequence-specific DNA binding
B7L46_RS07960	COG1335	isochorismatase
B7L46_RS07965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L46_RS07975	COG0668	transmembrane transport
B7L46_RS07980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L46_RS07985	COG1519	Transferase
B7L46_RS07990	COG1902	pentaerythritol trinitrate reductase activity
B7L46_RS08015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L46_RS08040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS08040	COG0426	domain, Protein
B7L46_RS08045	COG4774	siderophore transport
B7L46_RS08050	COG2119	membrane
B7L46_RS08060	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L46_RS08070	COG4942	peptidase
B7L46_RS08085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B7L46_RS08095	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B7L46_RS08115	COG0189	ligase activity
B7L46_RS08145	COG0708	Exodeoxyribonuclease III
B7L46_RS08150	COG1393	Belongs to the ArsC family
B7L46_RS08165	COG3706	GGDEF domain
B7L46_RS08200	COG2351	hydroxyisourate hydrolase activity
B7L46_RS08205	COG2233	PERMEase
B7L46_RS08215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS08225	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B7L46_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS08240	COG3150	esterase
B7L46_RS08285	COG3409	Peptidoglycan-binding domain 1 protein
B7L46_RS08285	COG5632	N-Acetylmuramoyl-L-alanine amidase
B7L46_RS08285	COG1388	LysM domain
B7L46_RS08300	COG2918	glutathione biosynthetic process
B7L46_RS08315	COG2733	membrane
B7L46_RS08320	COG0436	Aminotransferase
B7L46_RS08325	COG0534	Mate efflux family protein
B7L46_RS08415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L46_RS08420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B7L46_RS08430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L46_RS08435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B7L46_RS08440	COG0546	phosphoglycolate phosphatase activity
B7L46_RS08450	COG0010	Belongs to the arginase family
B7L46_RS08480	COG2188	Transcriptional regulator
B7L46_RS08490	COG0523	cobalamin synthesis protein
B7L46_RS08500	COG1113	amino acid transport
B7L46_RS08510	COG0625	glutathione transferase activity
B7L46_RS08530	COG1683	Conserved Protein
B7L46_RS08535	COG0534	Mate efflux family protein
B7L46_RS08540	COG0385	Bile acid
B7L46_RS08545	COG1335	isochorismatase
B7L46_RS08550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L46_RS08570	COG2116	formate transmembrane transporter activity
B7L46_RS08575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B7L46_RS08580	COG2133	pyrroloquinoline quinone binding
B7L46_RS08585	COG2983	Belongs to the UPF0260 family
B7L46_RS08605	COG1194	a g-specific adenine glycosylase
B7L46_RS08620	COG2818	Glycosylase
B7L46_RS08625	COG1064	alcohol dehydrogenase
B7L46_RS08630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L46_RS08640	COG0583	DNA-binding transcription factor activity
B7L46_RS08645	COG0656	L-ascorbic acid biosynthetic process
B7L46_RS08650	COG2814	Major facilitator Superfamily
B7L46_RS08685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS08700	COG2233	PERMEase
B7L46_RS08705	COG0583	DNA-binding transcription factor activity
B7L46_RS08740	COG0733	neurotransmitter:sodium symporter activity
B7L46_RS08785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L46_RS08790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B7L46_RS08795	COG0596	Alpha beta hydrolase
B7L46_RS08820	COG0488	(ABC) transporter
B7L46_RS08825	COG0586	Pfam SNARE associated Golgi protein
B7L46_RS08835	COG0187	DNA topoisomerase II activity
B7L46_RS08845	COG0592	DNA-directed DNA polymerase activity
B7L46_RS08870	COG0706	membrane insertase activity
B7L46_RS08885	COG1230	cation diffusion facilitator family transporter
B7L46_RS08890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L46_RS08905	COG0402	S-adenosylhomocysteine deaminase activity
B7L46_RS08915	COG0754	glutathionylspermidine amidase activity
B7L46_RS08925	COG0861	Integral membrane protein TerC family
B7L46_RS08930	COG0671	phosphoesterase, PA-phosphatase related
B7L46_RS08940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L46_RS08960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B7L46_RS08965	COG2951	lytic endotransglycosylase activity
B7L46_RS08995	COG0583	DNA-binding transcription factor activity
B7L46_RS09015	COG0657	acetylesterase activity
B7L46_RS09020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L46_RS09060	COG1047	Peptidyl-prolyl cis-trans
B7L46_RS09070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L46_RS09075	COG0196	riboflavin kinase activity
B7L46_RS09085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B7L46_RS09090	COG1309	transcriptional regulator
B7L46_RS09095	COG1116	anion transmembrane transporter activity
B7L46_RS09100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L46_RS09105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS09110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L46_RS09115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L46_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS09140	COG0546	phosphoglycolate phosphatase activity
B7L46_RS09190	COG3023	N-Acetylmuramoyl-L-alanine amidase
B7L46_RS09195	COG0728	peptidoglycan biosynthetic process
B7L46_RS09220	COG1596	polysaccharide export
B7L46_RS09225	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B7L46_RS09235	COG1216	Glycosyl transferase, family 2
B7L46_RS09235	COG1442	glycosyl transferase family 8
B7L46_RS09245	COG1216	Glycosyl transferase, family 2
B7L46_RS09255	COG1216	Glycosyl transferase, family 2
B7L46_RS09260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B7L46_RS09265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L46_RS09280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7L46_RS09290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L46_RS09300	COG2186	Transcriptional regulator
B7L46_RS09310	COG0277	FAD linked oxidase domain protein
B7L46_RS09315	COG1448	Aminotransferase
B7L46_RS09320	COG1802	Transcriptional regulator
B7L46_RS09335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B7L46_RS09435	COG0564	pseudouridine synthase activity
B7L46_RS09475	COG0251	oxidation-reduction process
B7L46_RS09480	COG1113	amino acid transport
B7L46_RS09485	COG1113	amino acid transport
B7L46_RS09505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B7L46_RS09510	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS09515	COG1024	Enoyl-CoA hydratase
B7L46_RS09520	COG1024	Enoyl-CoA hydratase
B7L46_RS09525	COG0477	Major facilitator Superfamily
B7L46_RS09530	COG3916	Acyl-homoserine-lactone synthase
B7L46_RS09540	COG2197	response regulator
B7L46_RS09550	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS09555	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B7L46_RS09555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B7L46_RS09555	COG3321	synthase
B7L46_RS09555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L46_RS09595	COG0271	Belongs to the BolA IbaG family
B7L46_RS09605	COG1192	Involved in chromosome partitioning
B7L46_RS09620	COG0586	Pfam SNARE associated Golgi protein
B7L46_RS09625	COG2259	Doxx family
B7L46_RS09630	COG4399	Belongs to the UPF0754 family
B7L46_RS09635	COG0519	Catalyzes the synthesis of GMP from XMP
B7L46_RS09635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L46_RS09680	COG0281	malic enzyme
B7L46_RS09685	COG2837	iron assimilation
B7L46_RS09690	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS09695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L46_RS09700	COG1121	(ABC) transporter
B7L46_RS09765	COG0386	Belongs to the glutathione peroxidase family
B7L46_RS09780	COG1309	transcriptional regulator
B7L46_RS09785	COG0697	spore germination
B7L46_RS09795	COG0758	DNA mediated transformation
B7L46_RS09830	COG1309	transcriptional regulator
B7L46_RS09875	COG0655	NAD(P)H dehydrogenase (quinone) activity
B7L46_RS09915	COG4452	Inner membrane protein CreD
B7L46_RS09920	COG2205	protein histidine kinase activity
B7L46_RS09925	COG0745	RESPONSE REGULATOR receiver
B7L46_RS09930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L46_RS09940	COG0477	Major facilitator Superfamily
B7L46_RS09950	COG1253	flavin adenine dinucleotide binding
B7L46_RS09955	COG3012	SEC-C Motif Domain Protein
B7L46_RS09960	COG2860	membrane
B7L46_RS09965	COG0477	Major facilitator Superfamily
B7L46_RS09975	COG0318	PFAM AMP-dependent synthetase and ligase
B7L46_RS09990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B7L46_RS10005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L46_RS10015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L46_RS10020	COG0606	chelatase, subunit chli
B7L46_RS10060	COG0589	response to stress
B7L46_RS10065	COG0659	secondary active sulfate transmembrane transporter activity
B7L46_RS10080	COG1061	Type III restriction enzyme res subunit
B7L46_RS10105	COG0606	chelatase, subunit chli
B7L46_RS10115	COG0347	Belongs to the P(II) protein family
B7L46_RS10120	COG0004	ammonium transporteR
B7L46_RS10130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L46_RS10130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L46_RS10170	COG0795	lipopolysaccharide-transporting ATPase activity
B7L46_RS10175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B7L46_RS10180	COG0793	Belongs to the peptidase S41A family
B7L46_RS10195	COG2197	response regulator
B7L46_RS10205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B7L46_RS10215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B7L46_RS10220	COG4974	Belongs to the 'phage' integrase family
B7L46_RS10245	COG0772	Belongs to the SEDS family
B7L46_RS10250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L46_RS10255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B7L46_RS10260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B7L46_RS10285	COG0697	spore germination
B7L46_RS10290	COG1538	Outer membrane efflux protein
B7L46_RS10310	COG3275	phosphorelay sensor kinase activity
B7L46_RS10320	COG0181	hydroxymethylbilane synthase activity
B7L46_RS10365	COG1716	ATPase activity
B7L46_RS10370	COG0546	phosphoglycolate phosphatase activity
B7L46_RS10470	COG2056	Na+-H+ antiporter family
B7L46_RS10485	COG0326	Molecular chaperone. Has ATPase activity
B7L46_RS10500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B7L46_RS10570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B7L46_RS10575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B7L46_RS10575	COG2169	Transcriptional regulator
B7L46_RS10605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L46_RS10615	COG0497	DNA recombination
B7L46_RS10630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L46_RS10640	COG0237	dephospho-CoA kinase activity
B7L46_RS10690	COG0195	Participates in both transcription termination and antitermination
B7L46_RS10705	COG1320	monovalent cation:proton antiporter activity
B7L46_RS10710	COG2212	antiporter activity
B7L46_RS10715	COG1863	multisubunit Na H antiporter MnhE subunit
B7L46_RS10720	COG0651	ATP synthesis coupled electron transport
B7L46_RS10725	COG1006	Multisubunit Na H antiporter MnhC subunit
B7L46_RS10730	COG2111	Na H antiporter
B7L46_RS10730	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L46_RS10745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L46_RS10760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS10775	COG2226	methyltransferase
B7L46_RS10795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B7L46_RS10800	COG1074	ATP-dependent DNA helicase activity
B7L46_RS10805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B7L46_RS10810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B7L46_RS10825	COG0598	Magnesium transport protein CorA
B7L46_RS10830	COG0789	Transcriptional regulator
B7L46_RS10835	COG0484	heat shock protein binding
B7L46_RS10850	COG0475	glutathione-regulated potassium exporter activity
B7L46_RS10850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L46_RS10855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L46_RS10875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L46_RS10885	COG4535	Mg2 and Co2 transporter CorC
B7L46_RS10890	COG0425	Belongs to the sulfur carrier protein TusA family
B7L46_RS10900	COG0644	oxidoreductase
B7L46_RS10900	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B7L46_RS10910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B7L46_RS10925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L46_RS10930	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B7L46_RS10940	COG0493	'glutamate synthase
B7L46_RS10940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L46_RS10965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B7L46_RS10980	COG0534	Mate efflux family protein
B7L46_RS10990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L46_RS10995	COG4221	oxidoreductase activity
B7L46_RS11000	COG0583	DNA-binding transcription factor activity
B7L46_RS11015	COG0318	PFAM AMP-dependent synthetase and ligase
B7L46_RS11020	COG1530	ribonuclease E activity
B7L46_RS11035	COG0546	phosphoglycolate phosphatase activity
B7L46_RS11040	COG2378	regulation of single-species biofilm formation
B7L46_RS11045	COG0625	glutathione transferase activity
B7L46_RS11055	COG0583	DNA-binding transcription factor activity
B7L46_RS11110	COG0473	3-isopropylmalate dehydrogenase activity
B7L46_RS11165	COG1301	dicarboxylic acid transport
B7L46_RS11175	COG1560	Kdo2-lipid A biosynthetic process
B7L46_RS11180	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS11190	COG0488	(ABC) transporter
B7L46_RS11195	COG2900	Belongs to the SlyX family
B7L46_RS11205	COG1733	regulation of RNA biosynthetic process
B7L46_RS11230	COG0210	DNA helicase
B7L46_RS11235	COG0724	RNA recognition motif
B7L46_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B7L46_RS11255	COG4651	solute:proton antiporter activity
B7L46_RS11280	COG0788	formyltetrahydrofolate deformylase activity
B7L46_RS11385	COG2813	Specifically methylates the guanine in position
B7L46_RS11385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L46_RS11395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L46_RS11405	COG4774	siderophore transport
B7L46_RS11415	COG0740	serine-type endopeptidase activity
B7L46_RS11435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B7L46_RS11435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B7L46_RS11440	COG0280	phosphate acetyltransferase
B7L46_RS11440	COG0857	belongs to the CobB CobQ family
B7L46_RS11445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B7L46_RS11455	COG0800	Aldolase
B7L46_RS11465	COG3265	gluconokinase activity
B7L46_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS11480	COG2267	carboxylic ester hydrolase activity
B7L46_RS11495	COG0793	Belongs to the peptidase S41A family
B7L46_RS11530	COG1426	Protein conserved in bacteria
B7L46_RS11570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B7L46_RS11580	COG1162	GTPase activity
B7L46_RS11585	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B7L46_RS11600	COG1538	Outer membrane efflux protein
B7L46_RS11605	COG0577	efflux transmembrane transporter activity
B7L46_RS11605	COG1136	(ABC) transporter
B7L46_RS11610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS11640	COG0028	Belongs to the TPP enzyme family
B7L46_RS11645	COG0440	acetolactate synthase activity
B7L46_RS11700	COG0482	sulfurtransferase activity
B7L46_RS11740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L46_RS11755	COG0084	hydrolase, TatD family'
B7L46_RS11770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L46_RS11775	COG0583	DNA-binding transcription factor activity
B7L46_RS11785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L46_RS11890	COG2205	protein histidine kinase activity
B7L46_RS11905	COG2132	Multicopper oxidase
B7L46_RS11915	COG0789	Transcriptional regulator
B7L46_RS11950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L46_RS11965	COG0640	Transcriptional regulator
B7L46_RS11975	COG0798	PFAM Bile acid sodium symporter
B7L46_RS11980	COG0431	NADPH-dependent FMN reductase
B7L46_RS11995	COG2814	Major facilitator Superfamily
B7L46_RS12005	COG0697	spore germination
B7L46_RS12035	COG3622	Belongs to the hyi family
B7L46_RS12040	COG2084	Dehydrogenase
B7L46_RS12045	COG1024	Enoyl-CoA hydratase
B7L46_RS12050	COG0784	Response regulator, receiver
B7L46_RS12050	COG2205	protein histidine kinase activity
B7L46_RS12050	COG5002	protein histidine kinase activity
B7L46_RS12070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L46_RS12080	COG3956	TIGRFAM MazG family protein
B7L46_RS12085	COG1555	photosystem II stabilization
B7L46_RS12090	COG0617	tRNA 3'-terminal CCA addition
B7L46_RS12095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L46_RS12115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L46_RS12120	COG3028	Belongs to the UPF0307 family
B7L46_RS12125	COG0318	PFAM AMP-dependent synthetase and ligase
B7L46_RS12145	COG0625	glutathione transferase activity
B7L46_RS12150	COG1238	metal cluster binding
B7L46_RS12195	COG0072	phenylalanine-tRNA ligase activity
B7L46_RS12220	COG0248	Ppx GppA phosphatase
B7L46_RS12230	COG0037	tRNA processing
B7L46_RS12270	COG1764	response to oxidative stress
B7L46_RS12275	COG1846	Transcriptional regulator
B7L46_RS12285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L46_RS12345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L46_RS12350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L46_RS12355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L46_RS12365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B7L46_RS12415	COG1214	PFAM Peptidase M22, glycoprotease
B7L46_RS12430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B7L46_RS12440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B7L46_RS12445	COG0561	phosphatase activity
B7L46_RS12455	COG2132	Multicopper oxidase
B7L46_RS12475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B7L46_RS12480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B7L46_RS12485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B7L46_RS12520	COG1063	alcohol dehydrogenase
B7L46_RS12525	COG0583	DNA-binding transcription factor activity
B7L46_RS12530	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS12535	COG2814	Major facilitator Superfamily
B7L46_RS12540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B7L46_RS12550	COG1053	succinate dehydrogenase
B7L46_RS12555	COG0583	DNA-binding transcription factor activity
B7L46_RS12575	COG0583	DNA-binding transcription factor activity
B7L46_RS12605	COG0583	DNA-binding transcription factor activity
B7L46_RS12620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS12630	COG1309	transcriptional regulator
B7L46_RS12650	COG0384	phenazine biosynthesis protein PhzF
B7L46_RS12660	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L46_RS12680	COG0745	RESPONSE REGULATOR receiver
B7L46_RS12720	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B7L46_RS12750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B7L46_RS12755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B7L46_RS12775	COG0583	DNA-binding transcription factor activity
B7L46_RS12795	COG0668	transmembrane transport
B7L46_RS12800	COG2081	HI0933 family
B7L46_RS12805	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B7L46_RS12835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L46_RS12835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L46_RS12855	COG0489	protein tyrosine kinase activity
B7L46_RS12910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L46_RS12920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L46_RS12935	COG0730	response to heat
B7L46_RS12945	COG1196	nuclear chromosome segregation
B7L46_RS12965	COG2223	nitrite transmembrane transporter activity
B7L46_RS12970	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B7L46_RS12975	COG1877	trehalose-phosphatase activity
B7L46_RS12980	COG2226	methyltransferase
B7L46_RS12980	COG0596	Alpha beta hydrolase
B7L46_RS12980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L46_RS12995	COG4106	trans-aconitate 2-methyltransferase activity
B7L46_RS13010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L46_RS13015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B7L46_RS13020	COG0009	L-threonylcarbamoyladenylate synthase
B7L46_RS13025	COG3101	peptidyl-lysine hydroxylation
B7L46_RS13030	COG1399	metal-binding, possibly nucleic acid-binding protein
B7L46_RS13055	COG1652	LysM domain
B7L46_RS13060	COG0351	phosphomethylpyrimidine kinase
B7L46_RS13060	COG0352	thiamine-phosphate diphosphorylase activity
B7L46_RS13060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B7L46_RS13070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B7L46_RS13100	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L46_RS13130	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B7L46_RS13145	COG0358	DNA primase activity
B7L46_RS13155	COG0564	pseudouridine synthase activity
B7L46_RS13180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B7L46_RS13200	COG0583	DNA-binding transcription factor activity
B7L46_RS13205	COG0473	3-isopropylmalate dehydrogenase activity
B7L46_RS13215	COG0657	acetylesterase activity
B7L46_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS13245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B7L46_RS13245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B7L46_RS13260	COG1981	membrane
B7L46_RS13305	COG0456	acetyltransferase
B7L46_RS13315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B7L46_RS13320	COG0492	ferredoxin-NADP+ reductase activity
B7L46_RS13325	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B7L46_RS13325	COG1674	ftsk spoiiie
B7L46_RS13330	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS13350	COG2894	cell division
B7L46_RS13365	COG0204	Acyl-transferase
B7L46_RS13370	COG2885	chlorophyll binding
B7L46_RS13375	COG0210	DNA helicase
B7L46_RS13385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L46_RS13400	COG0121	glutamine amidotransferase
B7L46_RS13425	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B7L46_RS13430	COG0735	belongs to the Fur family
B7L46_RS13455	COG0420	3'-5' exonuclease activity
B7L46_RS13475	COG1090	epimerase
B7L46_RS13490	COG2050	protein possibly involved in aromatic compounds catabolism
B7L46_RS13500	COG2814	Major facilitator Superfamily
B7L46_RS13505	COG0405	Gamma-glutamyltransferase
B7L46_RS13575	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B7L46_RS13585	COG0477	Major facilitator Superfamily
B7L46_RS13590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L46_RS13600	COG1595	DNA-templated transcription, initiation
B7L46_RS13655	COG0531	amino acid
B7L46_RS13660	COG2040	homocysteine
B7L46_RS13685	COG1309	transcriptional regulator
B7L46_RS13690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L46_RS13695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B7L46_RS13705	COG1607	acyl-coa hydrolase
B7L46_RS13715	COG0523	cobalamin synthesis protein
B7L46_RS13725	COG4681	YaeQ
B7L46_RS13735	COG0726	polysaccharide deacetylase
B7L46_RS13735	COG1649	PFAM Uncharacterised BCR, COG1649
B7L46_RS13740	COG1215	transferase activity, transferring glycosyl groups
B7L46_RS13750	COG1024	Enoyl-CoA hydratase
B7L46_RS13765	COG1414	Transcriptional regulator
B7L46_RS13785	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS13800	COG2271	Major facilitator Superfamily
B7L46_RS13810	COG2267	carboxylic ester hydrolase activity
B7L46_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS13830	COG0028	Belongs to the TPP enzyme family
B7L46_RS13840	COG0477	Major facilitator Superfamily
B7L46_RS13845	COG0242	peptide deformylase activity
B7L46_RS13850	COG2066	Belongs to the glutaminase family
B7L46_RS13855	COG2207	Transcriptional regulator
B7L46_RS13860	COG2223	nitrite transmembrane transporter activity
B7L46_RS13880	COG0583	DNA-binding transcription factor activity
B7L46_RS13885	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS13890	COG2271	Major facilitator Superfamily
B7L46_RS13895	COG3959	Transketolase, thiamine diphosphate binding domain
B7L46_RS13900	COG3958	Transketolase
B7L46_RS13910	COG0306	phosphate transporter
B7L46_RS13925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L46_RS13970	COG4181	ATPase activity
B7L46_RS13975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B7L46_RS14000	COG0583	DNA-binding transcription factor activity
B7L46_RS14010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L46_RS14015	COG1773	rubredoxin
B7L46_RS14060	COG2851	Citrate transporter
B7L46_RS14070	COG1253	flavin adenine dinucleotide binding
B7L46_RS14110	COG0804	urea catabolic process
B7L46_RS14120	COG0830	nickel cation binding
B7L46_RS14135	COG0742	ribosomal rna small subunit methyltransferase
B7L46_RS14140	COG0768	penicillin binding
B7L46_RS14165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L46_RS14170	COG2878	Part of a membrane complex involved in electron transport
B7L46_RS14175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B7L46_RS14185	COG3384	dioxygenase
B7L46_RS14200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B7L46_RS14235	COG0006	proline dipeptidase activity
B7L46_RS14240	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS14245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS14265	COG1279	arginine transmembrane transporter activity
B7L46_RS14270	COG0583	DNA-binding transcription factor activity
B7L46_RS14310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L46_RS14315	COG0741	lytic transglycosylase activity
B7L46_RS14315	COG1388	LysM domain
B7L46_RS14315	COG0741	lytic transglycosylase activity
B7L46_RS14315	COG1388	LysM domain
B7L46_RS14325	COG4174	ABC transporter (Permease)
B7L46_RS14330	COG4239	(ABC) transporter, permease
B7L46_RS14335	COG4172	Belongs to the ABC transporter superfamily
B7L46_RS14365	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B7L46_RS14375	COG5001	Diguanylate cyclase
B7L46_RS14375	COG4251	negative regulation of phosphorylation
B7L46_RS14375	COG3706	GGDEF domain
B7L46_RS14375	COG2203	Gaf domain
B7L46_RS14390	COG1902	pentaerythritol trinitrate reductase activity
B7L46_RS14390	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L46_RS14425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L46_RS14435	COG0583	DNA-binding transcription factor activity
B7L46_RS14440	COG2814	Major facilitator Superfamily
B7L46_RS14455	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS14460	COG1454	alcohol dehydrogenase
B7L46_RS14465	COG3485	protocatechuate 3,4-dioxygenase
B7L46_RS14480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L46_RS14485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L46_RS14490	COG0183	Belongs to the thiolase family
B7L46_RS14525	COG1113	amino acid transport
B7L46_RS14535	COG0531	amino acid
B7L46_RS14555	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS14575	COG1113	amino acid transport
B7L46_RS14590	COG0697	spore germination
B7L46_RS14595	COG2721	sulfolactate sulfo-lyase activity
B7L46_RS14600	COG2271	Major facilitator Superfamily
B7L46_RS14605	COG4948	Mandelate Racemase Muconate Lactonizing
B7L46_RS14615	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS14625	COG2186	Transcriptional regulator
B7L46_RS14650	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS14660	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS14665	COG1024	Enoyl-CoA hydratase
B7L46_RS14670	COG2814	Major facilitator Superfamily
B7L46_RS14685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B7L46_RS14700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B7L46_RS14740	COG2207	Transcriptional regulator
B7L46_RS14745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B7L46_RS14750	COG2072	flavoprotein involved in K transport
B7L46_RS14755	COG0300	oxidoreductase activity
B7L46_RS14765	COG1309	transcriptional regulator
B7L46_RS14770	COG1741	Belongs to the pirin family
B7L46_RS14785	COG2072	flavoprotein involved in K transport
B7L46_RS14795	COG2252	PERMEase
B7L46_RS14800	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B7L46_RS14805	COG3038	cytochrome b561
B7L46_RS14815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B7L46_RS14825	COG0527	aspartate kinase activity
B7L46_RS14835	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B7L46_RS14845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L46_RS14860	COG0667	Aldo Keto reductase
B7L46_RS14870	COG1765	OsmC-like protein
B7L46_RS14885	COG0542	response to heat
B7L46_RS14920	COG2885	chlorophyll binding
B7L46_RS14930	COG0625	glutathione transferase activity
B7L46_RS14935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L46_RS14955	COG3634	alkyl hydroperoxide reductase activity
B7L46_RS14965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B7L46_RS14975	COG0450	alkyl hydroperoxide reductase
B7L46_RS14980	COG1643	Atp-dependent helicase
B7L46_RS14995	COG2814	Major facilitator Superfamily
B7L46_RS15000	COG3135	benzoate transporter
B7L46_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS15010	COG0543	2 iron, 2 sulfur cluster binding
B7L46_RS15010	COG0633	Ferredoxin
B7L46_RS15015	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B7L46_RS15020	COG4638	Rieske (2fe-2S)
B7L46_RS15025	COG0583	DNA-binding transcription factor activity
B7L46_RS15035	COG2871	sodium ion transport
B7L46_RS15120	COG1570	exodeoxyribonuclease VII activity
B7L46_RS15155	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS15160	COG1278	Cold shock
B7L46_RS15195	COG2814	Major facilitator Superfamily
B7L46_RS15355	COG5410	chromosome segregation
B7L46_RS15360	COG3567	Phage-associated protein, HI1409 family
B7L46_RS15380	COG3566	protein conserved in bacteria
B7L46_RS15530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L46_RS15540	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B7L46_RS15545	COG1137	ATPase activity
B7L46_RS15550	COG1538	Outer membrane efflux protein
B7L46_RS15580	COG4122	O-methyltransferase activity
B7L46_RS15590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B7L46_RS15605	COG1522	sequence-specific DNA binding
B7L46_RS15610	COG5006	permease, DMT superfamily
B7L46_RS15620	COG1560	Kdo2-lipid A biosynthetic process
B7L46_RS15625	COG0598	Magnesium transport protein CorA
B7L46_RS15645	COG2814	Major facilitator Superfamily
B7L46_RS15665	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L46_RS15685	COG0583	DNA-binding transcription factor activity
B7L46_RS15690	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L46_RS15710	COG4770	biotin carboxylase activity
B7L46_RS15715	COG0038	chloride channel
B7L46_RS15720	COG2831	hemolysin activation secretion protein
B7L46_RS15725	COG3210	domain, Protein
B7L46_RS15740	COG1309	transcriptional regulator
B7L46_RS15750	COG1063	alcohol dehydrogenase
B7L46_RS15775	COG0439	Biotin carboxylase
B7L46_RS15780	COG2249	NAD(P)H dehydrogenase (quinone) activity
B7L46_RS15785	COG1733	regulation of RNA biosynthetic process
B7L46_RS15790	COG0864	Transcriptional regulator
B7L46_RS15800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7L46_RS15805	COG1116	anion transmembrane transporter activity
B7L46_RS15965	COG0590	tRNA wobble adenosine to inosine editing
B7L46_RS15970	COG2807	transmembrane transport
B7L46_RS15985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L46_RS15995	COG0789	Transcriptional regulator
B7L46_RS16010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L46_RS16030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B7L46_RS16055	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS16060	COG0531	amino acid
B7L46_RS16065	COG1760	l-serine dehydratase
B7L46_RS16070	COG2030	dehydratase
B7L46_RS16070	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS16075	COG3396	Phenylacetate-CoA oxygenase
B7L46_RS16080	COG3460	Phenylacetate-CoA oxygenase
B7L46_RS16085	COG3396	Phenylacetate-CoA oxygenase
B7L46_RS16090	COG2151	metal-sulfur cluster biosynthetic enzyme
B7L46_RS16095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B7L46_RS16100	COG1024	Enoyl-CoA hydratase
B7L46_RS16105	COG1024	Enoyl-CoA hydratase
B7L46_RS16110	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L46_RS16115	COG0183	Belongs to the thiolase family
B7L46_RS16120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B7L46_RS16125	COG3327	negative regulation of DNA-templated transcription, initiation
B7L46_RS16135	COG2050	protein possibly involved in aromatic compounds catabolism
B7L46_RS16145	COG0556	nucleotide-excision repair
B7L46_RS16165	COG2207	Transcriptional regulator
B7L46_RS16180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B7L46_RS16185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L46_RS16190	COG2271	Major facilitator Superfamily
B7L46_RS16195	COG0753	catalase activity
B7L46_RS16200	COG3038	cytochrome b561
B7L46_RS16220	COG2267	carboxylic ester hydrolase activity
B7L46_RS16225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS16230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS16235	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS16240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B7L46_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS16255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L46_RS16260	COG0583	DNA-binding transcription factor activity
B7L46_RS16270	COG1414	Transcriptional regulator
B7L46_RS16275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS16285	COG1840	ABC-type Fe3 transport system, periplasmic component
B7L46_RS16290	COG3842	ATPase activity
B7L46_RS16305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B7L46_RS16310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B7L46_RS16315	COG2814	Major facilitator Superfamily
B7L46_RS16320	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS16335	COG1024	Enoyl-CoA hydratase
B7L46_RS16345	COG2814	Major facilitator Superfamily
B7L46_RS16355	COG0183	Belongs to the thiolase family
B7L46_RS16360	COG1250	3-hydroxyacyl-CoA dehydrogenase
B7L46_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS16370	COG1024	Enoyl-CoA hydratase
B7L46_RS16375	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS16385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L46_RS16390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L46_RS16400	COG2814	Major facilitator Superfamily
B7L46_RS16410	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS16425	COG0583	DNA-binding transcription factor activity
B7L46_RS16435	COG4770	biotin carboxylase activity
B7L46_RS16440	COG1024	Enoyl-CoA hydratase
B7L46_RS16445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L46_RS16450	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS16455	COG1309	transcriptional regulator
B7L46_RS16460	COG0318	PFAM AMP-dependent synthetase and ligase
B7L46_RS16480	COG0583	DNA-binding transcription factor activity
B7L46_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS16545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L46_RS16565	COG2205	protein histidine kinase activity
B7L46_RS16565	COG0784	Response regulator, receiver
B7L46_RS16600	COG0765	amino acid transport
B7L46_RS16605	COG0765	amino acid transport
B7L46_RS16615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7L46_RS16620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7L46_RS16630	COG1280	lysine exporter protein (LysE YggA)
B7L46_RS16635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L46_RS16640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L46_RS16645	COG1045	serine acetyltransferase
B7L46_RS16660	COG0583	DNA-binding transcription factor activity
B7L46_RS16665	COG0625	glutathione transferase activity
B7L46_RS16670	COG0625	glutathione transferase activity
B7L46_RS16675	COG0583	DNA-binding transcription factor activity
B7L46_RS16685	COG1346	cytolysis
B7L46_RS16710	COG0300	oxidoreductase activity
B7L46_RS16720	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B7L46_RS16725	COG3052	prosthetic group binding
B7L46_RS16745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L46_RS16765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L46_RS16770	COG1294	oxidase, subunit
B7L46_RS16775	COG1271	oxidase subunit
B7L46_RS16800	COG0477	Major facilitator Superfamily
B7L46_RS16810	COG4521	taurine ABC transporter
B7L46_RS16815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B7L46_RS16820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L46_RS16825	COG2175	clavaminate synthase activity
B7L46_RS16835	COG1953	Uracil, thiamine, allantoin
B7L46_RS16845	COG0583	DNA-binding transcription factor activity
B7L46_RS16855	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B7L46_RS16870	COG0640	Transcriptional regulator
B7L46_RS16875	COG0798	PFAM Bile acid sodium symporter
B7L46_RS16880	COG0583	DNA-binding transcription factor activity
B7L46_RS16895	COG3634	alkyl hydroperoxide reductase activity
B7L46_RS16935	COG0436	Aminotransferase
B7L46_RS16945	COG0386	Belongs to the glutathione peroxidase family
B7L46_RS16985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B7L46_RS17010	COG0012	GTP binding
B7L46_RS17015	COG2011	ABC-type metal ion transport system permease component
B7L46_RS17020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L46_RS17030	COG1464	Belongs to the NlpA lipoprotein family
B7L46_RS17060	COG0765	amino acid transport
B7L46_RS17065	COG0765	amino acid transport
B7L46_RS17070	COG1126	abc transporter atp-binding protein
B7L46_RS17080	COG1522	sequence-specific DNA binding
B7L46_RS17095	COG1309	transcriptional regulator
B7L46_RS17115	COG0583	DNA-binding transcription factor activity
B7L46_RS17135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B7L46_RS17145	COG0697	spore germination
B7L46_RS17175	COG3121	Chaperone
B7L46_RS17180	COG3539	Fimbrial protein
B7L46_RS17205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L46_RS17205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L46_RS17250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B7L46_RS17260	COG2353	YceI-like domain
B7L46_RS17270	COG3698	Phosphodiester glycosidase
B7L46_RS17285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B7L46_RS17290	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B7L46_RS17290	COG0506	proline dehydrogenase activity
B7L46_RS17290	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B7L46_RS17300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L46_RS17305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B7L46_RS17325	COG1132	(ABC) transporter
B7L46_RS17330	COG3122	Protein conserved in bacteria
B7L46_RS17335	COG3619	membrane
B7L46_RS17345	COG0640	Transcriptional regulator
B7L46_RS17355	COG2850	peptidyl-arginine hydroxylation
B7L46_RS17360	COG0424	maF-like protein
B7L46_RS17380	COG0191	fructose-bisphosphate aldolase activity
B7L46_RS17385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L46_RS17400	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B7L46_RS17410	COG1192	Involved in chromosome partitioning
B7L46_RS17415	COG1475	DNA binding
B7L46_RS17420	COG0811	peptide transport
B7L46_RS17430	COG1132	(ABC) transporter
B7L46_RS17435	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L46_RS17455	COG0084	hydrolase, TatD family'
B7L46_RS17520	COG0776	regulation of translation
B7L46_RS17550	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B7L46_RS17555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B7L46_RS17590	COG4166	transmembrane transport
B7L46_RS17600	COG0339	signal peptide processing
B7L46_RS17610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L46_RS17645	COG0702	epimerase
B7L46_RS17650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L46_RS17670	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L46_RS17700	COG0316	Belongs to the HesB IscA family
B7L46_RS17705	COG0822	iron-sulfur transferase activity
B7L46_RS17730	COG0776	regulation of translation
B7L46_RS17735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B7L46_RS17740	COG2207	Transcriptional regulator
B7L46_RS17745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L46_RS17750	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS17755	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS17770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L46_RS17800	COG4264	IucA IucC family
B7L46_RS17805	COG4264	IucA IucC family
B7L46_RS17815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B7L46_RS17865	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L46_RS17880	COG0406	alpha-ribazole phosphatase activity
B7L46_RS17895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B7L46_RS17905	COG0730	response to heat
B7L46_RS17925	COG4773	Receptor
B7L46_RS17930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L46_RS17945	COG1131	(ABC) transporter
B7L46_RS17950	COG0842	Transport permease protein
B7L46_RS17955	COG0842	Transport permease protein
B7L46_RS18010	COG2226	methyltransferase
B7L46_RS18035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L46_RS18065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L46_RS18075	COG0133	tryptophan synthase activity
B7L46_RS18090	COG3706	GGDEF domain
B7L46_RS18105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B7L46_RS18110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B7L46_RS18115	COG0022	dehydrogenase e1 component
B7L46_RS18120	COG0508	dehydrogenase complex catalyzes the overall conversion of
B7L46_RS18125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L46_RS18135	COG1063	alcohol dehydrogenase
B7L46_RS18140	COG3781	membrane
B7L46_RS18150	COG3453	Protein conserved in bacteria
B7L46_RS18150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L46_RS18160	COG0730	response to heat
B7L46_RS18175	COG2207	Transcriptional regulator
B7L46_RS18175	COG3708	Transcriptional regulator
B7L46_RS18180	COG1733	regulation of RNA biosynthetic process
B7L46_RS18185	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L46_RS18195	COG2188	Transcriptional regulator
B7L46_RS18215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L46_RS18235	COG0477	Major facilitator Superfamily
B7L46_RS18245	COG1027	Aspartate ammonia-lyase
B7L46_RS18260	COG0583	DNA-binding transcription factor activity
B7L46_RS18265	COG0583	DNA-binding transcription factor activity
B7L46_RS18270	COG0183	Belongs to the thiolase family
B7L46_RS18275	COG2031	fatty acid transporter
B7L46_RS18290	COG0583	DNA-binding transcription factor activity
B7L46_RS18310	COG1309	transcriptional regulator
B7L46_RS18320	COG2610	gluconate transmembrane transporter activity
B7L46_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS18330	COG2207	Transcriptional regulator
B7L46_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS18355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS18370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B7L46_RS18370	COG0543	2 iron, 2 sulfur cluster binding
B7L46_RS18375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B7L46_RS18380	COG4638	Rieske (2fe-2S)
B7L46_RS18390	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L46_RS18395	COG4149	molybdate abc transporter
B7L46_RS18400	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L46_RS18405	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS18410	COG1535	isochorismatase
B7L46_RS18410	COG3433	isochorismatase activity
B7L46_RS18470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B7L46_RS18490	COG0753	catalase activity
B7L46_RS18505	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B7L46_RS18530	COG3539	Fimbrial protein
B7L46_RS18555	COG0747	negative chemotaxis
B7L46_RS18560	COG0601	transmembrane transport
B7L46_RS18565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L46_RS18585	COG1132	(ABC) transporter
B7L46_RS18590	COG1132	(ABC) transporter
B7L46_RS18605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS18620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L46_RS18635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L46_RS18640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L46_RS18645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L46_RS18650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS18690	COG4771	TonB-dependent receptor
B7L46_RS18695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B7L46_RS18710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B7L46_RS18715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B7L46_RS18720	COG0745	RESPONSE REGULATOR receiver
B7L46_RS18725	COG2205	protein histidine kinase activity
B7L46_RS18735	COG2207	Transcriptional regulator
B7L46_RS18750	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS18785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L46_RS18835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B7L46_RS18855	COG1120	ATPase activity
B7L46_RS18860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L46_RS18870	COG1064	alcohol dehydrogenase
B7L46_RS18885	COG2207	Transcriptional regulator
B7L46_RS18890	COG2084	Dehydrogenase
B7L46_RS18900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L46_RS18905	COG0583	DNA-binding transcription factor activity
B7L46_RS18915	COG0129	dihydroxy-acid dehydratase activity
B7L46_RS18920	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS18935	COG1566	PFAM secretion protein HlyD family protein
B7L46_RS18945	COG2271	Major facilitator Superfamily
B7L46_RS18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B7L46_RS18985	COG0583	DNA-binding transcription factor activity
B7L46_RS19000	COG2188	Transcriptional regulator
B7L46_RS19035	COG4993	Dehydrogenase
B7L46_RS19040	COG1733	regulation of RNA biosynthetic process
B7L46_RS19055	COG2259	Doxx family
B7L46_RS19060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B7L46_RS19110	COG1309	transcriptional regulator
B7L46_RS19140	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B7L46_RS19150	COG1902	pentaerythritol trinitrate reductase activity
B7L46_RS19150	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L46_RS19155	COG1846	Transcriptional regulator
B7L46_RS19185	COG0753	catalase activity
B7L46_RS19200	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS19215	COG3162	membrane
B7L46_RS19230	COG3829	transcription factor binding
B7L46_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS19240	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS19255	COG3231	kanamycin kinase activity
B7L46_RS19260	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS19280	COG2186	Transcriptional regulator
B7L46_RS19290	COG0583	DNA-binding transcription factor activity
B7L46_RS19295	COG4948	Mandelate Racemase Muconate Lactonizing
B7L46_RS19300	COG4829	muconolactone delta-isomerase
B7L46_RS19310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L46_RS19315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L46_RS19320	COG0183	Belongs to the thiolase family
B7L46_RS19325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B7L46_RS19330	COG1012	belongs to the aldehyde dehydrogenase family
B7L46_RS19340	COG3733	amine oxidase
B7L46_RS19350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L46_RS19360	COG1028	Short-chain dehydrogenase reductase Sdr
B7L46_RS19370	COG4638	Rieske (2fe-2S)
B7L46_RS19390	COG0154	amidase activity
B7L46_RS19400	COG2814	Major facilitator Superfamily
B7L46_RS19425	COG1960	acyl-CoA dehydrogenase activity
B7L46_RS19430	COG0583	DNA-binding transcription factor activity
B7L46_RS19435	COG1414	Transcriptional regulator
B7L46_RS19450	COG2391	methyltransferase activity
B7L46_RS19460	COG4993	Dehydrogenase
B7L46_RS19465	COG3659	wide pore channel activity
B7L46_RS19470	COG3420	alginic acid biosynthetic process
B7L46_RS19475	COG0710	3-dehydroquinate dehydratase activity
B7L46_RS19480	COG3485	protocatechuate 3,4-dioxygenase
B7L46_RS19485	COG3485	protocatechuate 3,4-dioxygenase
B7L46_RS19490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B7L46_RS19495	COG2271	Major facilitator Superfamily
B7L46_RS19500	COG0596	Alpha beta hydrolase
B7L46_RS19505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B7L46_RS19510	COG0183	Belongs to the thiolase family
B7L46_RS19515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B7L46_RS19520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B7L46_RS19530	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B7L46_RS19580	COG1902	pentaerythritol trinitrate reductase activity
B7L46_RS19580	COG0446	pyridine nucleotide-disulphide oxidoreductase
B7L46_RS19605	COG0542	response to heat
B7L46_RS19610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B7L46_RS19640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L46_RS19645	COG0569	domain protein
B7L46_RS19650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7L46_RS19665	COG4774	siderophore transport
B7L46_RS19670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L46_RS19680	COG1585	Membrane protein implicated in regulation of membrane protease activity
B7L46_RS19695	COG1294	oxidase, subunit
B7L46_RS19700	COG4890	Cyd operon protein YbgT
B7L46_RS19710	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
B7L46_RS19720	COG0552	protein localization to endoplasmic reticulum
B7L46_RS19750	COG0516	GMP reductase activity
B7L46_RS19750	COG0517	IMP dehydrogenase activity
B7L46_RS19755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L46_RS19760	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B7L46_RS19770	COG0583	DNA-binding transcription factor activity
B7L46_RS19775	COG0024	Methionine aminopeptidase
B7L46_RS19805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L46_RS19805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L46_RS19810	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L46_RS19815	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B7L46_RS19815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L46_RS19815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L46_RS19830	COG5001	Diguanylate cyclase
B7L46_RS19830	COG3300	MHYT domain
B7L46_RS19855	COG2135	peptidase activity
B7L46_RS19860	COG0659	secondary active sulfate transmembrane transporter activity
B7L46_RS19875	COG1113	amino acid transport
B7L46_RS19885	COG1522	sequence-specific DNA binding
B7L46_RS19910	COG1011	Hydrolase
B7L46_RS19915	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B7L46_RS19925	COG2137	regulation of response to DNA damage stimulus
B7L46_RS19940	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L46_RS19975	COG0575	Belongs to the CDS family
B7L46_RS19980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L46_RS20005	COG3852	Histidine kinase
B7L46_RS20010	COG2204	response regulator
B7L46_RS20070	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B7L46_RS20075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B7L46_RS20095	COG0697	spore germination
B7L46_RS20100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L46_RS20110	COG0303	'Molybdopterin
B7L46_RS20115	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L46_RS20115	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L46_RS20130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L46_RS20135	COG0243	molybdopterin cofactor binding
B7L46_RS20145	COG0243	molybdopterin cofactor binding
B7L46_RS20150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L46_RS20155	COG2146	nitrite reductase [NAD(P)H] activity
B7L46_RS20155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L46_RS20165	COG0745	RESPONSE REGULATOR receiver
B7L46_RS20170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L46_RS20170	COG1116	anion transmembrane transporter activity
B7L46_RS20185	COG0511	ligase activity, forming carbon-carbon bonds
B7L46_RS20200	COG2814	Major facilitator Superfamily
B7L46_RS20240	COG5301	cellulose 1,4-beta-cellobiosidase activity
B7L46_RS20535	COG0069	glutamate synthase activity
B7L46_RS20555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L46_RS20565	COG1454	alcohol dehydrogenase
B7L46_RS20570	COG0824	Thioesterase