locus-tag	class	description
IOMTU433_RS00025	COG0592	DNA-directed DNA polymerase activity
IOMTU433_RS00035	COG0187	DNA topoisomerase II activity
IOMTU433_RS00045	COG0586	Pfam SNARE associated Golgi protein
IOMTU433_RS00050	COG0488	(ABC) transporter
IOMTU433_RS00075	COG0596	Alpha beta hydrolase
IOMTU433_RS00080	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IOMTU433_RS00085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOMTU433_RS00125	COG0733	neurotransmitter:sodium symporter activity
IOMTU433_RS00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IOMTU433_RS00160	COG0583	DNA-binding transcription factor activity
IOMTU433_RS00165	COG2233	PERMEase
IOMTU433_RS00180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS00215	COG2814	Major facilitator Superfamily
IOMTU433_RS00220	COG0656	L-ascorbic acid biosynthetic process
IOMTU433_RS00225	COG0583	DNA-binding transcription factor activity
IOMTU433_RS00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_RS00240	COG1064	alcohol dehydrogenase
IOMTU433_RS00245	COG2818	Glycosylase
IOMTU433_RS00260	COG1194	a g-specific adenine glycosylase
IOMTU433_RS00270	COG0400	carboxylic ester hydrolase activity
IOMTU433_RS00280	COG2983	Belongs to the UPF0260 family
IOMTU433_RS00285	COG2133	pyrroloquinoline quinone binding
IOMTU433_RS00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOMTU433_RS00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_RS00320	COG1335	isochorismatase
IOMTU433_RS00325	COG0385	Bile acid
IOMTU433_RS00330	COG0534	Mate efflux family protein
IOMTU433_RS00335	COG1683	Conserved Protein
IOMTU433_RS00355	COG0625	glutathione transferase activity
IOMTU433_RS00365	COG1113	amino acid transport
IOMTU433_RS00375	COG0523	cobalamin synthesis protein
IOMTU433_RS00385	COG2188	Transcriptional regulator
IOMTU433_RS00415	COG0010	Belongs to the arginase family
IOMTU433_RS00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOMTU433_RS00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOMTU433_RS00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOMTU433_RS00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOMTU433_RS00495	COG0753	catalase activity
IOMTU433_RS00555	COG0534	Mate efflux family protein
IOMTU433_RS00560	COG0436	Aminotransferase
IOMTU433_RS00565	COG2733	membrane
IOMTU433_RS00580	COG2918	glutathione biosynthetic process
IOMTU433_RS00605	COG2826	transposase and inactivated derivatives, IS30 family
IOMTU433_RS00640	COG0673	inositol 2-dehydrogenase activity
IOMTU433_RS00660	COG2826	transposase and inactivated derivatives, IS30 family
IOMTU433_RS00680	COG3150	esterase
IOMTU433_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS00695	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IOMTU433_RS00705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_RS00715	COG2233	PERMEase
IOMTU433_RS00720	COG2351	hydroxyisourate hydrolase activity
IOMTU433_RS00755	COG3706	GGDEF domain
IOMTU433_RS00770	COG1393	Belongs to the ArsC family
IOMTU433_RS00775	COG0708	Exodeoxyribonuclease III
IOMTU433_RS00795	COG0189	ligase activity
IOMTU433_RS00815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IOMTU433_RS00825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOMTU433_RS00840	COG4942	peptidase
IOMTU433_RS00850	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOMTU433_RS00860	COG2119	membrane
IOMTU433_RS00865	COG4774	siderophore transport
IOMTU433_RS00870	COG0426	domain, Protein
IOMTU433_RS00870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS00895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IOMTU433_RS00915	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_RS00920	COG1519	Transferase
IOMTU433_RS00925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOMTU433_RS00930	COG0668	transmembrane transport
IOMTU433_RS00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_RS00945	COG1335	isochorismatase
IOMTU433_RS00950	COG1522	sequence-specific DNA binding
IOMTU433_RS00975	COG0784	Response regulator, receiver
IOMTU433_RS00975	COG2198	Histidine kinase
IOMTU433_RS00975	COG2205	protein histidine kinase activity
IOMTU433_RS00980	COG3162	membrane
IOMTU433_RS00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOMTU433_RS00995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_RS01015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOMTU433_RS01020	COG1309	transcriptional regulator
IOMTU433_RS01040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOMTU433_RS01040	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_RS01040	COG0351	phosphomethylpyrimidine kinase
IOMTU433_RS01050	COG2814	Major facilitator Superfamily
IOMTU433_RS01065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOMTU433_RS01075	COG1113	amino acid transport
IOMTU433_RS01085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS01100	COG1335	isochorismatase
IOMTU433_RS01130	COG2814	Major facilitator Superfamily
IOMTU433_RS01135	COG0583	DNA-binding transcription factor activity
IOMTU433_RS01155	COG0667	Aldo Keto reductase
IOMTU433_RS01185	COG1733	regulation of RNA biosynthetic process
IOMTU433_RS01190	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS01265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IOMTU433_RS01280	COG2329	Antibiotic biosynthesis monooxygenase
IOMTU433_RS01310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOMTU433_RS01340	COG0427	acetyl-CoA hydrolase
IOMTU433_RS01360	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_RS01365	COG4221	oxidoreductase activity
IOMTU433_RS01370	COG2873	o-acetylhomoserine
IOMTU433_RS01375	COG0488	(ABC) transporter
IOMTU433_RS01455	COG0833	amino acid
IOMTU433_RS01500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOMTU433_RS01505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOMTU433_RS01520	COG2226	methyltransferase
IOMTU433_RS01570	COG0067	glutamate synthase
IOMTU433_RS01570	COG0070	glutamate synthase
IOMTU433_RS01570	COG0069	glutamate synthase activity
IOMTU433_RS01575	COG0493	'glutamate synthase
IOMTU433_RS01585	COG1704	LemA family
IOMTU433_RS01590	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IOMTU433_RS01605	COG3307	-O-antigen
IOMTU433_RS01625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOMTU433_RS01635	COG0194	GDP metabolic process
IOMTU433_RS01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOMTU433_RS01705	COG5380	lipid catabolic process
IOMTU433_RS01710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IOMTU433_RS01735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOMTU433_RS01740	COG0277	FAD linked oxidase domain protein
IOMTU433_RS01750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IOMTU433_RS01755	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS01770	COG1289	transmembrane transporter activity
IOMTU433_RS01780	COG0628	permease
IOMTU433_RS01785	COG1192	Involved in chromosome partitioning
IOMTU433_RS01815	COG0833	amino acid
IOMTU433_RS01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOMTU433_RS01825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOMTU433_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS01875	COG0583	DNA-binding transcription factor activity
IOMTU433_RS01925	COG0517	IMP dehydrogenase activity
IOMTU433_RS01930	COG1983	PspC domain protein
IOMTU433_RS01940	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS01955	COG0408	coproporphyrinogen oxidase activity
IOMTU433_RS01975	COG0513	Belongs to the DEAD box helicase family
IOMTU433_RS01985	COG1127	ABC transporter
IOMTU433_RS01990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOMTU433_RS02000	COG2854	intermembrane phospholipid transfer
IOMTU433_RS02010	COG0598	Magnesium transport protein CorA
IOMTU433_RS02020	COG0494	nUDIX hydrolase
IOMTU433_RS02025	COG1040	competence protein
IOMTU433_RS02030	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOMTU433_RS02050	COG1946	Acyl-CoA thioesterase
IOMTU433_RS02055	COG1301	dicarboxylic acid transport
IOMTU433_RS02070	COG1959	2 iron, 2 sulfur cluster binding
IOMTU433_RS02075	COG1017	nitric oxide dioxygenase activity
IOMTU433_RS02075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_RS02080	COG0433	COG0433 Predicted ATPase
IOMTU433_RS02085	COG0626	cystathionine gamma-synthase activity
IOMTU433_RS02240	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS02245	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IOMTU433_RS02275	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IOMTU433_RS02280	COG0339	signal peptide processing
IOMTU433_RS02285	COG0557	exoribonuclease II activity
IOMTU433_RS02340	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOMTU433_RS02345	COG2169	Transcriptional regulator
IOMTU433_RS02350	COG0697	spore germination
IOMTU433_RS02355	COG1295	ribonuclease BN
IOMTU433_RS02390	COG1702	phosphate starvation-inducible protein PhoH
IOMTU433_RS02400	COG0741	lytic transglycosylase activity
IOMTU433_RS02400	COG0739	heme binding
IOMTU433_RS02400	COG1196	nuclear chromosome segregation
IOMTU433_RS02430	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IOMTU433_RS02435	COG1183	phosphatidylcholine synthase activity
IOMTU433_RS02480	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS02485	COG1309	transcriptional regulator
IOMTU433_RS02500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOMTU433_RS02505	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS02545	COG2969	positive regulation of protein catabolic process
IOMTU433_RS02555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOMTU433_RS02570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IOMTU433_RS02575	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IOMTU433_RS02595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IOMTU433_RS02605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOMTU433_RS02610	COG1408	metallophosphoesterase
IOMTU433_RS02620	COG2199	diguanylate cyclase activity
IOMTU433_RS02680	COG1607	acyl-coa hydrolase
IOMTU433_RS02710	COG2350	Protein conserved in bacteria
IOMTU433_RS02720	COG0613	PHP domain protein
IOMTU433_RS02725	COG3781	membrane
IOMTU433_RS02735	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IOMTU433_RS02745	COG2801	Transposase and inactivated derivatives
IOMTU433_RS02750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOMTU433_RS02760	COG1862	Preprotein translocase
IOMTU433_RS02800	COG2205	protein histidine kinase activity
IOMTU433_RS02805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IOMTU433_RS02820	COG0726	polysaccharide deacetylase
IOMTU433_RS02825	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_RS02835	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_RS02850	COG1442	glycosyl transferase family 8
IOMTU433_RS02900	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS02905	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS02915	COG2205	protein histidine kinase activity
IOMTU433_RS02920	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS02925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IOMTU433_RS02945	COG2096	Adenosyltransferase
IOMTU433_RS02995	COG0285	dihydrofolate synthase activity
IOMTU433_RS03015	COG0450	alkyl hydroperoxide reductase
IOMTU433_RS03030	COG0477	Major facilitator Superfamily
IOMTU433_RS03035	COG1272	protein, Hemolysin III
IOMTU433_RS03045	COG2153	protein acetylation
IOMTU433_RS03065	COG0183	Belongs to the thiolase family
IOMTU433_RS03070	COG2207	Transcriptional regulator
IOMTU433_RS03090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_RS03110	COG0183	Belongs to the thiolase family
IOMTU433_RS03120	COG2885	chlorophyll binding
IOMTU433_RS03120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IOMTU433_RS03130	COG1690	Belongs to the RtcB family
IOMTU433_RS03135	COG0833	amino acid
IOMTU433_RS03145	COG2233	PERMEase
IOMTU433_RS03150	COG1217	gtp-binding protein TYPA
IOMTU433_RS03175	COG2094	Belongs to the DNA glycosylase MPG family
IOMTU433_RS03180	COG4772	TonB-dependent receptor
IOMTU433_RS03185	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_RS03190	COG0679	Auxin Efflux Carrier
IOMTU433_RS03200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_RS03205	COG0354	folic acid binding
IOMTU433_RS03215	COG3189	MarR family transcriptional regulator
IOMTU433_RS03220	COG2824	Alkylphosphonate utilization operon protein PhnA
IOMTU433_RS03225	COG3422	double-strand break repair
IOMTU433_RS03265	COG0840	transmembrane signaling receptor activity
IOMTU433_RS03285	COG5510	response to toxic substance
IOMTU433_RS03295	COG2832	Protein of unknown function (DUF454)
IOMTU433_RS03300	COG1376	ErfK ybiS ycfS ynhG family protein
IOMTU433_RS03340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IOMTU433_RS03350	COG1289	transmembrane transporter activity
IOMTU433_RS03355	COG2814	Major facilitator Superfamily
IOMTU433_RS03370	COG1115	amino acid carrier protein
IOMTU433_RS03375	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOMTU433_RS03380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOMTU433_RS03385	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOMTU433_RS03390	COG3590	peptidase
IOMTU433_RS03415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOMTU433_RS03425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOMTU433_RS03430	COG1077	Cell shape determining protein MreB Mrl
IOMTU433_RS03435	COG1792	Involved in formation and maintenance of cell shape
IOMTU433_RS03440	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IOMTU433_RS03445	COG0424	maF-like protein
IOMTU433_RS03450	COG1530	ribonuclease E activity
IOMTU433_RS03460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_RS03470	COG0560	Phosphoserine phosphatase
IOMTU433_RS03480	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS03515	COG2207	Transcriptional regulator
IOMTU433_RS03535	COG1113	amino acid transport
IOMTU433_RS03540	COG2828	Protein conserved in bacteria
IOMTU433_RS03545	COG0142	geranyltranstransferase activity
IOMTU433_RS03550	COG2315	Protein conserved in bacteria
IOMTU433_RS03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
IOMTU433_RS03585	COG2194	sulfuric ester hydrolase activity
IOMTU433_RS03590	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS03595	COG0642	Histidine kinase
IOMTU433_RS03605	COG0004	ammonium transporteR
IOMTU433_RS03610	COG0583	DNA-binding transcription factor activity
IOMTU433_RS03630	COG0525	valine-tRNA ligase activity
IOMTU433_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS03650	COG0393	Putative heavy-metal-binding
IOMTU433_RS03655	COG0393	Putative heavy-metal-binding
IOMTU433_RS03660	COG1538	Outer membrane efflux protein
IOMTU433_RS03670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS03675	COG0671	phosphoesterase, PA-phosphatase related
IOMTU433_RS03705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOMTU433_RS03720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IOMTU433_RS03720	COG1648	precorrin-2 dehydrogenase activity
IOMTU433_RS03725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOMTU433_RS03730	COG1733	regulation of RNA biosynthetic process
IOMTU433_RS03740	COG0531	amino acid
IOMTU433_RS03755	COG0321	lipoyl(octanoyl) transferase activity
IOMTU433_RS03760	COG2921	Belongs to the UPF0250 family
IOMTU433_RS03795	COG2009	succinate dehydrogenase
IOMTU433_RS03800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IOMTU433_RS03805	COG1053	succinate dehydrogenase
IOMTU433_RS03810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOMTU433_RS03825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_RS03845	COG2354	Protein conserved in bacteria
IOMTU433_RS03850	COG2321	neutral zinc metallopeptidase
IOMTU433_RS03870	COG2843	Capsule synthesis protein
IOMTU433_RS03885	COG0589	response to stress
IOMTU433_RS03895	COG0251	oxidation-reduction process
IOMTU433_RS03900	COG1309	transcriptional regulator
IOMTU433_RS03915	COG0505	Belongs to the CarA family
IOMTU433_RS03940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOMTU433_RS03945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOMTU433_RS03995	COG0477	Major facilitator Superfamily
IOMTU433_RS04000	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IOMTU433_RS04015	COG1597	lipid kinase activity
IOMTU433_RS04020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOMTU433_RS04050	COG0584	glycerophosphoryl diester phosphodiesterase
IOMTU433_RS04070	COG0741	lytic transglycosylase activity
IOMTU433_RS04090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOMTU433_RS04105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_RS04115	COG3811	Belongs to the UPF0386 family
IOMTU433_RS04135	COG0778	Nitroreductase
IOMTU433_RS04150	COG1929	Belongs to the glycerate kinase type-1 family
IOMTU433_RS04155	COG0243	molybdopterin cofactor binding
IOMTU433_RS04160	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOMTU433_RS04165	COG3339	Conserved Protein
IOMTU433_RS04175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IOMTU433_RS04190	COG1113	amino acid transport
IOMTU433_RS04200	COG0019	diaminopimelate decarboxylase activity
IOMTU433_RS04210	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS04215	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IOMTU433_RS04245	COG0463	Glycosyl transferase, family 2
IOMTU433_RS04265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS04295	COG4591	ABC-type transport system involved in lipoprotein release permease component
IOMTU433_RS04300	COG1136	(ABC) transporter
IOMTU433_RS04305	COG2333	competence protein COMEC
IOMTU433_RS04305	COG0658	competence protein
IOMTU433_RS04315	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOMTU433_RS04315	COG0616	signal peptide processing
IOMTU433_RS04320	COG0596	Alpha beta hydrolase
IOMTU433_RS04325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOMTU433_RS04335	COG0628	permease
IOMTU433_RS04370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOMTU433_RS04390	COG0823	Involved in the tonB-independent uptake of proteins
IOMTU433_RS04410	COG0824	Thioesterase
IOMTU433_RS04415	COG1473	amidohydrolase
IOMTU433_RS04435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOMTU433_RS04435	COG0047	phosphoribosylformylglycinamidine synthase activity
IOMTU433_RS04440	COG2814	Major facilitator Superfamily
IOMTU433_RS04455	COG1024	Enoyl-CoA hydratase
IOMTU433_RS04460	COG1051	belongs to the nudix hydrolase family
IOMTU433_RS04460	COG1056	cytidyltransferase-related domain
IOMTU433_RS04470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOMTU433_RS04485	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IOMTU433_RS04500	COG4625	pathogenesis
IOMTU433_RS04505	COG0583	DNA-binding transcription factor activity
IOMTU433_RS04510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IOMTU433_RS04515	COG4208	sulfate ABC transporter
IOMTU433_RS04520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IOMTU433_RS04530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IOMTU433_RS04535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_RS04540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IOMTU433_RS04560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOMTU433_RS04570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOMTU433_RS04580	COG0681	Belongs to the peptidase S26 family
IOMTU433_RS04595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOMTU433_RS04605	COG1381	Involved in DNA repair and RecF pathway recombination
IOMTU433_RS04610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOMTU433_RS04620	COG4221	oxidoreductase activity
IOMTU433_RS04645	COG0443	Heat shock 70 kDa protein
IOMTU433_RS04655	COG0436	Aminotransferase
IOMTU433_RS04675	COG0556	nucleotide-excision repair
IOMTU433_RS04730	COG2070	2-Nitropropane dioxygenase
IOMTU433_RS04760	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_RS04775	COG0415	Belongs to the DNA photolyase family
IOMTU433_RS04785	COG1252	NADH dehydrogenase
IOMTU433_RS04790	COG1686	Belongs to the peptidase S11 family
IOMTU433_RS04805	COG1187	pseudouridine synthase activity
IOMTU433_RS04875	COG3645	SOS response
IOMTU433_RS04875	COG3646	Phage regulatory protein
IOMTU433_RS05145	COG0582	viral genome integration into host DNA
IOMTU433_RS05165	COG0477	Major facilitator Superfamily
IOMTU433_RS05170	COG0583	DNA-binding transcription factor activity
IOMTU433_RS05175	COG1823	symporter activity
IOMTU433_RS05185	COG0612	Peptidase, M16
IOMTU433_RS05210	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_RS05245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_RS05255	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS05270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IOMTU433_RS05275	COG0076	glutamate decarboxylase activity
IOMTU433_RS05285	COG1522	sequence-specific DNA binding
IOMTU433_RS05290	COG3961	Belongs to the TPP enzyme family
IOMTU433_RS05295	COG1113	amino acid transport
IOMTU433_RS05300	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOMTU433_RS05305	COG0573	inorganic phosphate transmembrane transporter activity
IOMTU433_RS05315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IOMTU433_RS05320	COG0616	signal peptide processing
IOMTU433_RS05355	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IOMTU433_RS05360	COG1686	Belongs to the peptidase S11 family
IOMTU433_RS05385	COG0583	DNA-binding transcription factor activity
IOMTU433_RS05390	COG1067	ATP-dependent peptidase activity
IOMTU433_RS05415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IOMTU433_RS05435	COG1966	Carbon starvation protein
IOMTU433_RS05440	COG2879	small protein
IOMTU433_RS05480	COG1335	isochorismatase
IOMTU433_RS05485	COG0583	DNA-binding transcription factor activity
IOMTU433_RS05500	COG0596	Alpha beta hydrolase
IOMTU433_RS05510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOMTU433_RS05520	COG2130	NADP-dependent
IOMTU433_RS05545	COG1741	Belongs to the pirin family
IOMTU433_RS05555	COG2964	Protein conserved in bacteria
IOMTU433_RS05570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_RS05575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOMTU433_RS05580	COG4605	iron ion homeostasis
IOMTU433_RS05585	COG4604	ABC transporter, ATP-binding protein
IOMTU433_RS05590	COG4607	ABC-type enterochelin transport system periplasmic component
IOMTU433_RS05595	COG4774	siderophore transport
IOMTU433_RS05605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_RS05610	COG1021	2,3-dihydroxybenzoate-AMP ligase
IOMTU433_RS05615	COG3433	isochorismatase activity
IOMTU433_RS05615	COG1535	isochorismatase
IOMTU433_RS05630	COG1132	(ABC) transporter
IOMTU433_RS05635	COG1132	(ABC) transporter
IOMTU433_RS05640	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IOMTU433_RS05650	COG1169	isochorismate synthase
IOMTU433_RS05665	COG3739	integral membrane protein
IOMTU433_RS05685	COG0302	gtp cyclohydrolase
IOMTU433_RS05695	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IOMTU433_RS05725	COG0308	aminopeptidase N
IOMTU433_RS05730	COG0512	Glutamine amidotransferase of anthranilate synthase
IOMTU433_RS05745	COG0174	glutamine synthetase
IOMTU433_RS05755	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IOMTU433_RS05790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOMTU433_RS05795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOMTU433_RS05800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOMTU433_RS05820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOMTU433_RS05825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IOMTU433_RS05830	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IOMTU433_RS05845	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS05850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOMTU433_RS05855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_RS05870	COG2223	nitrite transmembrane transporter activity
IOMTU433_RS05880	COG0024	Methionine aminopeptidase
IOMTU433_RS05885	COG0052	Belongs to the universal ribosomal protein uS2 family
IOMTU433_RS05900	COG2207	Transcriptional regulator
IOMTU433_RS05925	COG2951	lytic endotransglycosylase activity
IOMTU433_RS05930	COG0772	Belongs to the SEDS family
IOMTU433_RS05945	COG0842	Transport permease protein
IOMTU433_RS05950	COG1131	(ABC) transporter
IOMTU433_RS05990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS06005	COG4215	(ABC) transporter
IOMTU433_RS06010	COG4160	amino acid transport
IOMTU433_RS06015	COG4598	ABC transporter
IOMTU433_RS06025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOMTU433_RS06030	COG0826	peptidase U32
IOMTU433_RS06050	COG1720	tRNA m6t6A37 methyltransferase activity
IOMTU433_RS06060	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOMTU433_RS06075	COG0642	Histidine kinase
IOMTU433_RS06085	COG0494	nUDIX hydrolase
IOMTU433_RS06095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IOMTU433_RS06100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOMTU433_RS06105	COG3139	Protein of unknown function (DUF1315)
IOMTU433_RS06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOMTU433_RS06115	COG1301	dicarboxylic acid transport
IOMTU433_RS06120	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS06125	COG2819	hydrolase of the alpha beta superfamily
IOMTU433_RS06135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOMTU433_RS06145	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOMTU433_RS06150	COG1234	tRNA 3'-trailer cleavage
IOMTU433_RS06180	COG2363	Small membrane protein
IOMTU433_RS06200	COG0513	Belongs to the DEAD box helicase family
IOMTU433_RS06210	COG0778	Nitroreductase
IOMTU433_RS06240	COG1286	toxin biosynthetic process
IOMTU433_RS06265	COG4783	chaperone-mediated protein folding
IOMTU433_RS06270	COG1610	YqeY-like protein
IOMTU433_RS06325	COG2831	hemolysin activation secretion protein
IOMTU433_RS06440	COG3111	PFAM Bacterial OB fold (BOF) protein
IOMTU433_RS06465	COG3243	poly(R)-hydroxyalkanoic acid synthase
IOMTU433_RS06470	COG0786	glutamate:sodium symporter activity
IOMTU433_RS06480	COG2186	Transcriptional regulator
IOMTU433_RS06530	COG0477	Major facilitator Superfamily
IOMTU433_RS06555	COG2985	domain, Protein
IOMTU433_RS06570	COG2995	paraquat-inducible protein a
IOMTU433_RS06575	COG3008	intermembrane lipid transfer
IOMTU433_RS06575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOMTU433_RS06585	COG2351	hydroxyisourate hydrolase activity
IOMTU433_RS06625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOMTU433_RS06635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOMTU433_RS06640	COG0642	Histidine kinase
IOMTU433_RS06645	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS06665	COG1794	racemase activity, acting on amino acids and derivatives
IOMTU433_RS06695	COG1301	dicarboxylic acid transport
IOMTU433_RS06705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_RS06710	COG2011	ABC-type metal ion transport system permease component
IOMTU433_RS06715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOMTU433_RS06720	COG1464	Belongs to the NlpA lipoprotein family
IOMTU433_RS06725	COG0151	Belongs to the GarS family
IOMTU433_RS06730	COG0138	bifunctional purine biosynthesis protein purh
IOMTU433_RS06735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IOMTU433_RS06765	COG2308	Evidence 4 Homologs of previously reported genes of
IOMTU433_RS06775	COG1305	Transglutaminase-like
IOMTU433_RS06785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOMTU433_RS06790	COG0305	Participates in initiation and elongation during chromosome replication
IOMTU433_RS06815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IOMTU433_RS06825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IOMTU433_RS06830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IOMTU433_RS06855	COG0726	polysaccharide deacetylase
IOMTU433_RS06855	COG1649	PFAM Uncharacterised BCR, COG1649
IOMTU433_RS06860	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_RS06865	COG3658	cytochrome
IOMTU433_RS06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_RS06890	COG0583	DNA-binding transcription factor activity
IOMTU433_RS06910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_RS06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_RS06930	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS06935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_RS06940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS06965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOMTU433_RS06970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOMTU433_RS06980	COG2205	protein histidine kinase activity
IOMTU433_RS06985	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS06990	COG0174	glutamine synthetase
IOMTU433_RS07010	COG0729	surface antigen
IOMTU433_RS07035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOMTU433_RS07040	COG2814	Major facilitator Superfamily
IOMTU433_RS07055	COG0583	DNA-binding transcription factor activity
IOMTU433_RS07070	COG1187	pseudouridine synthase activity
IOMTU433_RS07090	COG0802	atpase or kinase
IOMTU433_RS07095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IOMTU433_RS07105	COG1923	regulation of RNA biosynthetic process
IOMTU433_RS07110	COG0697	spore germination
IOMTU433_RS07135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOMTU433_RS07140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOMTU433_RS07140	COG0519	Catalyzes the synthesis of GMP from XMP
IOMTU433_RS07145	COG4302	ethanolamine ammonia-lyase activity
IOMTU433_RS07150	COG4303	Ethanolamine ammonia lyase large subunit
IOMTU433_RS07155	COG0531	amino acid
IOMTU433_RS07175	COG1454	alcohol dehydrogenase
IOMTU433_RS07180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOMTU433_RS07205	COG0308	aminopeptidase N
IOMTU433_RS07235	COG4221	oxidoreductase activity
IOMTU433_RS07245	COG1605	Chorismate mutase
IOMTU433_RS07265	COG1309	transcriptional regulator
IOMTU433_RS07275	COG0668	transmembrane transport
IOMTU433_RS07305	COG4773	Receptor
IOMTU433_RS07325	COG0488	(ABC) transporter
IOMTU433_RS07330	COG0589	response to stress
IOMTU433_RS07350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IOMTU433_RS07360	COG3135	benzoate transporter
IOMTU433_RS07365	COG1522	sequence-specific DNA binding
IOMTU433_RS07375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOMTU433_RS07380	COG0583	DNA-binding transcription factor activity
IOMTU433_RS07390	COG0183	Belongs to the thiolase family
IOMTU433_RS07400	COG2030	dehydratase
IOMTU433_RS07405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOMTU433_RS07420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOMTU433_RS07430	COG0824	Thioesterase
IOMTU433_RS07435	COG1454	alcohol dehydrogenase
IOMTU433_RS07445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOMTU433_RS07475	COG0069	glutamate synthase activity
IOMTU433_RS07555	COG3620	sequence-specific DNA binding
IOMTU433_RS07745	COG1598	PFAM Uncharacterised protein family UPF0150
IOMTU433_RS07755	COG1196	nuclear chromosome segregation
IOMTU433_RS07755	COG0741	lytic transglycosylase activity
IOMTU433_RS07755	COG0739	heme binding
IOMTU433_RS07795	COG3179	chitinase
IOMTU433_RS07805	COG1063	alcohol dehydrogenase
IOMTU433_RS07810	COG3293	Transposase
IOMTU433_RS07845	COG2814	Major facilitator Superfamily
IOMTU433_RS07860	COG0511	ligase activity, forming carbon-carbon bonds
IOMTU433_RS07875	COG1116	anion transmembrane transporter activity
IOMTU433_RS07875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_RS07880	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS07890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_RS07890	COG2146	nitrite reductase [NAD(P)H] activity
IOMTU433_RS07895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_RS07900	COG0243	molybdopterin cofactor binding
IOMTU433_RS07910	COG0243	molybdopterin cofactor binding
IOMTU433_RS07915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOMTU433_RS07930	COG0315	cyclic pyranopterin monophosphate synthase activity
IOMTU433_RS07930	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOMTU433_RS07945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_RS07950	COG0697	spore germination
IOMTU433_RS07970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IOMTU433_RS07975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOMTU433_RS08030	COG2204	response regulator
IOMTU433_RS08035	COG3852	Histidine kinase
IOMTU433_RS08055	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IOMTU433_RS08060	COG0575	Belongs to the CDS family
IOMTU433_RS08095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOMTU433_RS08105	COG2137	regulation of response to DNA damage stimulus
IOMTU433_RS08115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOMTU433_RS08120	COG1011	Hydrolase
IOMTU433_RS08145	COG1522	sequence-specific DNA binding
IOMTU433_RS08155	COG1113	amino acid transport
IOMTU433_RS08170	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_RS08175	COG2135	peptidase activity
IOMTU433_RS08190	COG5001	Diguanylate cyclase
IOMTU433_RS08190	COG3300	MHYT domain
IOMTU433_RS08210	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IOMTU433_RS08210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOMTU433_RS08210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IOMTU433_RS08215	COG1105	Belongs to the carbohydrate kinase PfkB family
IOMTU433_RS08220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IOMTU433_RS08220	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOMTU433_RS08250	COG0024	Methionine aminopeptidase
IOMTU433_RS08255	COG0583	DNA-binding transcription factor activity
IOMTU433_RS08265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IOMTU433_RS08270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOMTU433_RS08275	COG0516	GMP reductase activity
IOMTU433_RS08275	COG0517	IMP dehydrogenase activity
IOMTU433_RS08300	COG0552	protein localization to endoplasmic reticulum
IOMTU433_RS08310	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IOMTU433_RS08325	COG4890	Cyd operon protein YbgT
IOMTU433_RS08330	COG1294	oxidase, subunit
IOMTU433_RS08345	COG1585	Membrane protein implicated in regulation of membrane protease activity
IOMTU433_RS08355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IOMTU433_RS08360	COG4774	siderophore transport
IOMTU433_RS08375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOMTU433_RS08380	COG0569	domain protein
IOMTU433_RS08385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOMTU433_RS08415	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IOMTU433_RS08420	COG0542	response to heat
IOMTU433_RS08445	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_RS08445	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_RS08490	COG2323	membrane
IOMTU433_RS08495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IOMTU433_RS08505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_RS08510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_RS08515	COG0183	Belongs to the thiolase family
IOMTU433_RS08520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOMTU433_RS08525	COG0596	Alpha beta hydrolase
IOMTU433_RS08530	COG2271	Major facilitator Superfamily
IOMTU433_RS08535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOMTU433_RS08540	COG3485	protocatechuate 3,4-dioxygenase
IOMTU433_RS08545	COG3485	protocatechuate 3,4-dioxygenase
IOMTU433_RS08550	COG0710	3-dehydroquinate dehydratase activity
IOMTU433_RS08555	COG3420	alginic acid biosynthetic process
IOMTU433_RS08560	COG3659	wide pore channel activity
IOMTU433_RS08565	COG4993	Dehydrogenase
IOMTU433_RS08575	COG2391	methyltransferase activity
IOMTU433_RS08590	COG1414	Transcriptional regulator
IOMTU433_RS08595	COG0583	DNA-binding transcription factor activity
IOMTU433_RS08600	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS08625	COG2814	Major facilitator Superfamily
IOMTU433_RS08635	COG0154	amidase activity
IOMTU433_RS08655	COG4638	Rieske (2fe-2S)
IOMTU433_RS08665	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS08675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS08685	COG3733	amine oxidase
IOMTU433_RS08695	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS08705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_RS08710	COG0183	Belongs to the thiolase family
IOMTU433_RS08715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_RS08720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_RS08730	COG4829	muconolactone delta-isomerase
IOMTU433_RS08735	COG4948	Mandelate Racemase Muconate Lactonizing
IOMTU433_RS08740	COG0583	DNA-binding transcription factor activity
IOMTU433_RS08750	COG2186	Transcriptional regulator
IOMTU433_RS08770	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS08785	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_RS08785	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_RS08795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IOMTU433_RS08830	COG1309	transcriptional regulator
IOMTU433_RS08835	COG0583	DNA-binding transcription factor activity
IOMTU433_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS08860	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS08870	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS08970	COG2188	Transcriptional regulator
IOMTU433_RS08985	COG0583	DNA-binding transcription factor activity
IOMTU433_RS09015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_RS09035	COG1566	PFAM secretion protein HlyD family protein
IOMTU433_RS09050	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS09055	COG0129	dihydroxy-acid dehydratase activity
IOMTU433_RS09065	COG0583	DNA-binding transcription factor activity
IOMTU433_RS09070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOMTU433_RS09080	COG2084	Dehydrogenase
IOMTU433_RS09085	COG2207	Transcriptional regulator
IOMTU433_RS09100	COG1064	alcohol dehydrogenase
IOMTU433_RS09110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOMTU433_RS09115	COG1120	ATPase activity
IOMTU433_RS09135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOMTU433_RS09185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOMTU433_RS09235	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
IOMTU433_RS09250	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS09260	COG2207	Transcriptional regulator
IOMTU433_RS09270	COG2205	protein histidine kinase activity
IOMTU433_RS09275	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS09280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS09285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOMTU433_RS09340	COG3539	Fimbrial protein
IOMTU433_RS09365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IOMTU433_RS09375	COG0753	catalase activity
IOMTU433_RS09390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IOMTU433_RS09450	COG3433	isochorismatase activity
IOMTU433_RS09450	COG1535	isochorismatase
IOMTU433_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS09460	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOMTU433_RS09465	COG4149	molybdate abc transporter
IOMTU433_RS09470	COG0725	ABC transporter, periplasmic molybdate-binding protein
IOMTU433_RS09480	COG4638	Rieske (2fe-2S)
IOMTU433_RS09485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOMTU433_RS09490	COG0543	2 iron, 2 sulfur cluster binding
IOMTU433_RS09490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_RS09505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS09515	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS09530	COG2207	Transcriptional regulator
IOMTU433_RS09535	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS09540	COG2610	gluconate transmembrane transporter activity
IOMTU433_RS09550	COG1309	transcriptional regulator
IOMTU433_RS09570	COG0583	DNA-binding transcription factor activity
IOMTU433_RS09585	COG2031	fatty acid transporter
IOMTU433_RS09590	COG0183	Belongs to the thiolase family
IOMTU433_RS09595	COG0583	DNA-binding transcription factor activity
IOMTU433_RS09600	COG0583	DNA-binding transcription factor activity
IOMTU433_RS09615	COG1027	Aspartate ammonia-lyase
IOMTU433_RS09625	COG0477	Major facilitator Superfamily
IOMTU433_RS09645	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_RS09650	COG4521	taurine ABC transporter
IOMTU433_RS09665	COG2188	Transcriptional regulator
IOMTU433_RS09675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IOMTU433_RS09680	COG1733	regulation of RNA biosynthetic process
IOMTU433_RS09685	COG3708	Transcriptional regulator
IOMTU433_RS09685	COG2207	Transcriptional regulator
IOMTU433_RS09700	COG0730	response to heat
IOMTU433_RS09710	COG3453	Protein conserved in bacteria
IOMTU433_RS09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_RS09720	COG3781	membrane
IOMTU433_RS09725	COG1063	alcohol dehydrogenase
IOMTU433_RS09735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IOMTU433_RS09740	COG0508	dehydrogenase complex catalyzes the overall conversion of
IOMTU433_RS09745	COG0022	dehydrogenase e1 component
IOMTU433_RS09750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IOMTU433_RS09755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IOMTU433_RS09770	COG3706	GGDEF domain
IOMTU433_RS09785	COG0133	tryptophan synthase activity
IOMTU433_RS09795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOMTU433_RS09830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOMTU433_RS09855	COG2226	methyltransferase
IOMTU433_RS09910	COG0842	Transport permease protein
IOMTU433_RS09915	COG0842	Transport permease protein
IOMTU433_RS09920	COG1131	(ABC) transporter
IOMTU433_RS09935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOMTU433_RS09940	COG4773	Receptor
IOMTU433_RS09960	COG0730	response to heat
IOMTU433_RS09965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IOMTU433_RS09980	COG0406	alpha-ribazole phosphatase activity
IOMTU433_RS10000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOMTU433_RS10030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_RS10040	COG4264	IucA IucC family
IOMTU433_RS10045	COG4264	IucA IucC family
IOMTU433_RS10065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IOMTU433_RS10080	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS10085	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS10090	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IOMTU433_RS10095	COG2207	Transcriptional regulator
IOMTU433_RS10100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOMTU433_RS10105	COG0776	regulation of translation
IOMTU433_RS10130	COG0822	iron-sulfur transferase activity
IOMTU433_RS10135	COG0316	Belongs to the HesB IscA family
IOMTU433_RS10165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOMTU433_RS10185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IOMTU433_RS10190	COG0702	epimerase
IOMTU433_RS10225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOMTU433_RS10235	COG0339	signal peptide processing
IOMTU433_RS10275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IOMTU433_RS10280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IOMTU433_RS10310	COG0776	regulation of translation
IOMTU433_RS10375	COG0084	hydrolase, TatD family'
IOMTU433_RS10395	COG1663	tetraacyldisaccharide 4'-kinase activity
IOMTU433_RS10400	COG1132	(ABC) transporter
IOMTU433_RS10410	COG0811	peptide transport
IOMTU433_RS10415	COG1475	DNA binding
IOMTU433_RS10420	COG1192	Involved in chromosome partitioning
IOMTU433_RS10430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IOMTU433_RS10445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOMTU433_RS10450	COG0191	fructose-bisphosphate aldolase activity
IOMTU433_RS10470	COG0424	maF-like protein
IOMTU433_RS10475	COG2850	peptidyl-arginine hydroxylation
IOMTU433_RS10485	COG0640	Transcriptional regulator
IOMTU433_RS10495	COG3619	membrane
IOMTU433_RS10500	COG3122	Protein conserved in bacteria
IOMTU433_RS10505	COG1132	(ABC) transporter
IOMTU433_RS10525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IOMTU433_RS10530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOMTU433_RS10540	COG0506	proline dehydrogenase activity
IOMTU433_RS10540	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOMTU433_RS10540	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IOMTU433_RS10545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IOMTU433_RS10560	COG3698	Phosphodiester glycosidase
IOMTU433_RS10570	COG2353	YceI-like domain
IOMTU433_RS10580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOMTU433_RS10625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOMTU433_RS10625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOMTU433_RS10650	COG3539	Fimbrial protein
IOMTU433_RS10655	COG3121	Chaperone
IOMTU433_RS10680	COG0697	spore germination
IOMTU433_RS10690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOMTU433_RS10700	COG0583	DNA-binding transcription factor activity
IOMTU433_RS10720	COG1309	transcriptional regulator
IOMTU433_RS10735	COG1522	sequence-specific DNA binding
IOMTU433_RS10745	COG1126	abc transporter atp-binding protein
IOMTU433_RS10750	COG0765	amino acid transport
IOMTU433_RS10755	COG0765	amino acid transport
IOMTU433_RS10785	COG1464	Belongs to the NlpA lipoprotein family
IOMTU433_RS10795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOMTU433_RS10800	COG2011	ABC-type metal ion transport system permease component
IOMTU433_RS10805	COG0012	GTP binding
IOMTU433_RS10830	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IOMTU433_RS10870	COG0386	Belongs to the glutathione peroxidase family
IOMTU433_RS10880	COG0436	Aminotransferase
IOMTU433_RS10885	COG1301	dicarboxylic acid transport
IOMTU433_RS10920	COG3634	alkyl hydroperoxide reductase activity
IOMTU433_RS10935	COG0583	DNA-binding transcription factor activity
IOMTU433_RS10940	COG0798	PFAM Bile acid sodium symporter
IOMTU433_RS10945	COG0640	Transcriptional regulator
IOMTU433_RS10960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IOMTU433_RS10970	COG0583	DNA-binding transcription factor activity
IOMTU433_RS10980	COG1953	Uracil, thiamine, allantoin
IOMTU433_RS10990	COG2175	clavaminate synthase activity
IOMTU433_RS10995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_RS11000	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IOMTU433_RS11005	COG4521	taurine ABC transporter
IOMTU433_RS11015	COG0477	Major facilitator Superfamily
IOMTU433_RS11035	COG1271	oxidase subunit
IOMTU433_RS11040	COG1294	oxidase, subunit
IOMTU433_RS11050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_RS11070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOMTU433_RS11090	COG3052	prosthetic group binding
IOMTU433_RS11095	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IOMTU433_RS11105	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11115	COG2814	Major facilitator Superfamily
IOMTU433_RS11135	COG1346	cytolysis
IOMTU433_RS11145	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11150	COG0625	glutathione transferase activity
IOMTU433_RS11155	COG0625	glutathione transferase activity
IOMTU433_RS11160	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11175	COG1045	serine acetyltransferase
IOMTU433_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IOMTU433_RS11185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOMTU433_RS11190	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS11200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOMTU433_RS11205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOMTU433_RS11215	COG0765	amino acid transport
IOMTU433_RS11220	COG0765	amino acid transport
IOMTU433_RS11235	COG0784	Response regulator, receiver
IOMTU433_RS11235	COG2205	protein histidine kinase activity
IOMTU433_RS11255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOMTU433_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS11325	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS11350	COG1309	transcriptional regulator
IOMTU433_RS11355	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS11360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IOMTU433_RS11365	COG1024	Enoyl-CoA hydratase
IOMTU433_RS11370	COG4770	biotin carboxylase activity
IOMTU433_RS11380	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11395	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS11405	COG2814	Major facilitator Superfamily
IOMTU433_RS11415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IOMTU433_RS11420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IOMTU433_RS11425	COG2814	Major facilitator Superfamily
IOMTU433_RS11430	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS11435	COG1024	Enoyl-CoA hydratase
IOMTU433_RS11440	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS11445	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_RS11450	COG0183	Belongs to the thiolase family
IOMTU433_RS11460	COG2814	Major facilitator Superfamily
IOMTU433_RS11470	COG1024	Enoyl-CoA hydratase
IOMTU433_RS11485	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS11490	COG2814	Major facilitator Superfamily
IOMTU433_RS11495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IOMTU433_RS11500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IOMTU433_RS11515	COG3842	ATPase activity
IOMTU433_RS11520	COG1840	ABC-type Fe3 transport system, periplasmic component
IOMTU433_RS11530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_RS11535	COG1414	Transcriptional regulator
IOMTU433_RS11545	COG0583	DNA-binding transcription factor activity
IOMTU433_RS11550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IOMTU433_RS11555	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS11565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IOMTU433_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS11575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_RS11580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS11585	COG2267	carboxylic ester hydrolase activity
IOMTU433_RS11605	COG3038	cytochrome b561
IOMTU433_RS11610	COG0753	catalase activity
IOMTU433_RS11615	COG2271	Major facilitator Superfamily
IOMTU433_RS11620	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOMTU433_RS11625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOMTU433_RS11640	COG2207	Transcriptional regulator
IOMTU433_RS11685	COG2050	protein possibly involved in aromatic compounds catabolism
IOMTU433_RS11695	COG3327	negative regulation of DNA-templated transcription, initiation
IOMTU433_RS11700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IOMTU433_RS11705	COG0183	Belongs to the thiolase family
IOMTU433_RS11710	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_RS11720	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_RS11725	COG1024	Enoyl-CoA hydratase
IOMTU433_RS11730	COG1024	Enoyl-CoA hydratase
IOMTU433_RS11735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_RS11740	COG2151	metal-sulfur cluster biosynthetic enzyme
IOMTU433_RS11745	COG3396	Phenylacetate-CoA oxygenase
IOMTU433_RS11750	COG3460	Phenylacetate-CoA oxygenase
IOMTU433_RS11755	COG3396	Phenylacetate-CoA oxygenase
IOMTU433_RS11760	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS11760	COG2030	dehydratase
IOMTU433_RS11765	COG1760	l-serine dehydratase
IOMTU433_RS11770	COG0531	amino acid
IOMTU433_RS11775	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS11800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOMTU433_RS11820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_RS11830	COG0789	Transcriptional regulator
IOMTU433_RS11840	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOMTU433_RS11855	COG2807	transmembrane transport
IOMTU433_RS11860	COG0590	tRNA wobble adenosine to inosine editing
IOMTU433_RS11975	COG1116	anion transmembrane transporter activity
IOMTU433_RS11990	COG0864	Transcriptional regulator
IOMTU433_RS12000	COG1733	regulation of RNA biosynthetic process
IOMTU433_RS12005	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS12010	COG0439	Biotin carboxylase
IOMTU433_RS12025	COG1063	alcohol dehydrogenase
IOMTU433_RS12035	COG1309	transcriptional regulator
IOMTU433_RS12050	COG3210	domain, Protein
IOMTU433_RS12055	COG2831	hemolysin activation secretion protein
IOMTU433_RS12060	COG0038	chloride channel
IOMTU433_RS12065	COG4770	biotin carboxylase activity
IOMTU433_RS12085	COG1914	H( )-stimulated, divalent metal cation uptake system
IOMTU433_RS12090	COG0583	DNA-binding transcription factor activity
IOMTU433_RS12150	COG1250	3-hydroxyacyl-CoA dehydrogenase
IOMTU433_RS12170	COG2814	Major facilitator Superfamily
IOMTU433_RS12180	COG1560	Kdo2-lipid A biosynthetic process
IOMTU433_RS12190	COG5006	permease, DMT superfamily
IOMTU433_RS12195	COG1522	sequence-specific DNA binding
IOMTU433_RS12210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IOMTU433_RS12220	COG4122	O-methyltransferase activity
IOMTU433_RS12250	COG1538	Outer membrane efflux protein
IOMTU433_RS12255	COG1137	ATPase activity
IOMTU433_RS12260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IOMTU433_RS12270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IOMTU433_RS12275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOMTU433_RS12275	COG0517	IMP dehydrogenase activity
IOMTU433_RS12320	COG2814	Major facilitator Superfamily
IOMTU433_RS12350	COG1278	Cold shock
IOMTU433_RS12355	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS12390	COG1570	exodeoxyribonuclease VII activity
IOMTU433_RS12470	COG2871	sodium ion transport
IOMTU433_RS12480	COG0583	DNA-binding transcription factor activity
IOMTU433_RS12485	COG4638	Rieske (2fe-2S)
IOMTU433_RS12490	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
IOMTU433_RS12495	COG0543	2 iron, 2 sulfur cluster binding
IOMTU433_RS12495	COG0633	Ferredoxin
IOMTU433_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS12505	COG3135	benzoate transporter
IOMTU433_RS12510	COG2814	Major facilitator Superfamily
IOMTU433_RS12525	COG1643	Atp-dependent helicase
IOMTU433_RS12530	COG0450	alkyl hydroperoxide reductase
IOMTU433_RS12540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOMTU433_RS12550	COG3634	alkyl hydroperoxide reductase activity
IOMTU433_RS12570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOMTU433_RS12575	COG0625	glutathione transferase activity
IOMTU433_RS12585	COG2885	chlorophyll binding
IOMTU433_RS12620	COG0542	response to heat
IOMTU433_RS12635	COG1765	OsmC-like protein
IOMTU433_RS12645	COG0667	Aldo Keto reductase
IOMTU433_RS12660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOMTU433_RS12675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOMTU433_RS12685	COG0582	viral genome integration into host DNA
IOMTU433_RS12820	COG3566	protein conserved in bacteria
IOMTU433_RS12840	COG3567	Phage-associated protein, HI1409 family
IOMTU433_RS12845	COG5410	chromosome segregation
IOMTU433_RS12945	COG4197	protein conserved in bacteria, prophage-related
IOMTU433_RS12950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IOMTU433_RS13005	COG0527	aspartate kinase activity
IOMTU433_RS13015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOMTU433_RS13025	COG3038	cytochrome b561
IOMTU433_RS13030	COG2801	Transposase and inactivated derivatives
IOMTU433_RS13040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IOMTU433_RS13045	COG2252	PERMEase
IOMTU433_RS13055	COG2072	flavoprotein involved in K transport
IOMTU433_RS13070	COG1741	Belongs to the pirin family
IOMTU433_RS13075	COG1309	transcriptional regulator
IOMTU433_RS13085	COG0300	oxidoreductase activity
IOMTU433_RS13090	COG2072	flavoprotein involved in K transport
IOMTU433_RS13095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IOMTU433_RS13140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOMTU433_RS13155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IOMTU433_RS13170	COG2814	Major facilitator Superfamily
IOMTU433_RS13175	COG1024	Enoyl-CoA hydratase
IOMTU433_RS13180	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS13190	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS13215	COG2186	Transcriptional regulator
IOMTU433_RS13220	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS13230	COG4948	Mandelate Racemase Muconate Lactonizing
IOMTU433_RS13235	COG2271	Major facilitator Superfamily
IOMTU433_RS13240	COG2721	sulfolactate sulfo-lyase activity
IOMTU433_RS13245	COG0697	spore germination
IOMTU433_RS13280	COG1113	amino acid transport
IOMTU433_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS13320	COG0531	amino acid
IOMTU433_RS13330	COG1113	amino acid transport
IOMTU433_RS13370	COG3209	COG3209 Rhs family protein
IOMTU433_RS13395	COG4269	membrane
IOMTU433_RS13410	COG1902	pentaerythritol trinitrate reductase activity
IOMTU433_RS13410	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_RS13425	COG2203	Gaf domain
IOMTU433_RS13425	COG4251	negative regulation of phosphorylation
IOMTU433_RS13425	COG5001	Diguanylate cyclase
IOMTU433_RS13425	COG3706	GGDEF domain
IOMTU433_RS13435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOMTU433_RS13455	COG4172	Belongs to the ABC transporter superfamily
IOMTU433_RS13460	COG4239	(ABC) transporter, permease
IOMTU433_RS13465	COG4174	ABC transporter (Permease)
IOMTU433_RS13475	COG1388	LysM domain
IOMTU433_RS13475	COG0741	lytic transglycosylase activity
IOMTU433_RS13475	COG1388	LysM domain
IOMTU433_RS13475	COG0741	lytic transglycosylase activity
IOMTU433_RS13480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IOMTU433_RS13520	COG0583	DNA-binding transcription factor activity
IOMTU433_RS13525	COG1279	arginine transmembrane transporter activity
IOMTU433_RS13545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_RS13550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IOMTU433_RS13555	COG0006	proline dipeptidase activity
IOMTU433_RS13580	COG2194	sulfuric ester hydrolase activity
IOMTU433_RS13630	COG0739	heme binding
IOMTU433_RS13645	COG1598	PFAM Uncharacterised protein family UPF0150
IOMTU433_RS13800	COG0270	DNA (cytosine-5-)-methyltransferase activity
IOMTU433_RS13890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IOMTU433_RS13915	COG3384	dioxygenase
IOMTU433_RS13925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IOMTU433_RS13930	COG2878	Part of a membrane complex involved in electron transport
IOMTU433_RS13935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOMTU433_RS13955	COG0768	penicillin binding
IOMTU433_RS13960	COG0742	ribosomal rna small subunit methyltransferase
IOMTU433_RS13975	COG0830	nickel cation binding
IOMTU433_RS13985	COG0804	urea catabolic process
IOMTU433_RS14030	COG1253	flavin adenine dinucleotide binding
IOMTU433_RS14035	COG2851	Citrate transporter
IOMTU433_RS14080	COG1773	rubredoxin
IOMTU433_RS14085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IOMTU433_RS14095	COG0583	DNA-binding transcription factor activity
IOMTU433_RS14120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IOMTU433_RS14125	COG4181	ATPase activity
IOMTU433_RS14170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IOMTU433_RS14190	COG0306	phosphate transporter
IOMTU433_RS14200	COG3958	Transketolase
IOMTU433_RS14205	COG3959	Transketolase, thiamine diphosphate binding domain
IOMTU433_RS14210	COG2271	Major facilitator Superfamily
IOMTU433_RS14215	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS14220	COG0583	DNA-binding transcription factor activity
IOMTU433_RS14235	COG2223	nitrite transmembrane transporter activity
IOMTU433_RS14240	COG2207	Transcriptional regulator
IOMTU433_RS14245	COG2066	Belongs to the glutaminase family
IOMTU433_RS14250	COG0242	peptide deformylase activity
IOMTU433_RS14255	COG0477	Major facilitator Superfamily
IOMTU433_RS14265	COG0028	Belongs to the TPP enzyme family
IOMTU433_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS14285	COG2267	carboxylic ester hydrolase activity
IOMTU433_RS14295	COG2271	Major facilitator Superfamily
IOMTU433_RS14300	COG0446	pyridine nucleotide-disulphide oxidoreductase
IOMTU433_RS14310	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS14330	COG1414	Transcriptional regulator
IOMTU433_RS14345	COG1024	Enoyl-CoA hydratase
IOMTU433_RS14355	COG1215	transferase activity, transferring glycosyl groups
IOMTU433_RS14360	COG0726	polysaccharide deacetylase
IOMTU433_RS14360	COG1649	PFAM Uncharacterised BCR, COG1649
IOMTU433_RS14370	COG4681	YaeQ
IOMTU433_RS14380	COG0523	cobalamin synthesis protein
IOMTU433_RS14390	COG1607	acyl-coa hydrolase
IOMTU433_RS14400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_RS14405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IOMTU433_RS14410	COG1309	transcriptional regulator
IOMTU433_RS14435	COG2040	homocysteine
IOMTU433_RS14440	COG0531	amino acid
IOMTU433_RS14495	COG1595	DNA-templated transcription, initiation
IOMTU433_RS14505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_RS14510	COG0477	Major facilitator Superfamily
IOMTU433_RS14565	COG0405	Gamma-glutamyltransferase
IOMTU433_RS14570	COG2814	Major facilitator Superfamily
IOMTU433_RS14580	COG2050	protein possibly involved in aromatic compounds catabolism
IOMTU433_RS14595	COG1090	epimerase
IOMTU433_RS14615	COG0420	3'-5' exonuclease activity
IOMTU433_RS14640	COG0735	belongs to the Fur family
IOMTU433_RS14645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOMTU433_RS14665	COG0121	glutamine amidotransferase
IOMTU433_RS14680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_RS14690	COG0210	DNA helicase
IOMTU433_RS14695	COG2885	chlorophyll binding
IOMTU433_RS14700	COG0204	Acyl-transferase
IOMTU433_RS14715	COG2894	cell division
IOMTU433_RS14730	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS14735	COG1674	ftsk spoiiie
IOMTU433_RS14735	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOMTU433_RS14740	COG0492	ferredoxin-NADP+ reductase activity
IOMTU433_RS14745	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IOMTU433_RS14755	COG0456	acetyltransferase
IOMTU433_RS14800	COG1981	membrane
IOMTU433_RS14815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOMTU433_RS14815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOMTU433_RS14835	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS14845	COG0657	acetylesterase activity
IOMTU433_RS14855	COG0473	3-isopropylmalate dehydrogenase activity
IOMTU433_RS14860	COG0583	DNA-binding transcription factor activity
IOMTU433_RS14875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOMTU433_RS14900	COG0564	pseudouridine synthase activity
IOMTU433_RS14910	COG0358	DNA primase activity
IOMTU433_RS14925	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IOMTU433_RS14955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOMTU433_RS14985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOMTU433_RS14995	COG0351	phosphomethylpyrimidine kinase
IOMTU433_RS14995	COG0352	thiamine-phosphate diphosphorylase activity
IOMTU433_RS14995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOMTU433_RS15000	COG1652	LysM domain
IOMTU433_RS15025	COG1399	metal-binding, possibly nucleic acid-binding protein
IOMTU433_RS15030	COG3101	peptidyl-lysine hydroxylation
IOMTU433_RS15035	COG0009	L-threonylcarbamoyladenylate synthase
IOMTU433_RS15040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IOMTU433_RS15045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IOMTU433_RS15060	COG4106	trans-aconitate 2-methyltransferase activity
IOMTU433_RS15075	COG2226	methyltransferase
IOMTU433_RS15075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_RS15075	COG0596	Alpha beta hydrolase
IOMTU433_RS15080	COG1877	trehalose-phosphatase activity
IOMTU433_RS15085	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IOMTU433_RS15090	COG2223	nitrite transmembrane transporter activity
IOMTU433_RS15110	COG1196	nuclear chromosome segregation
IOMTU433_RS15120	COG0730	response to heat
IOMTU433_RS15135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOMTU433_RS15145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOMTU433_RS15200	COG0489	protein tyrosine kinase activity
IOMTU433_RS15210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_RS15210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_RS15240	COG2515	1-aminocyclopropane-1-carboxylate deaminase
IOMTU433_RS15245	COG2081	HI0933 family
IOMTU433_RS15255	COG0668	transmembrane transport
IOMTU433_RS15275	COG0583	DNA-binding transcription factor activity
IOMTU433_RS15300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOMTU433_RS15305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOMTU433_RS15335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IOMTU433_RS15375	COG0745	RESPONSE REGULATOR receiver
IOMTU433_RS15395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOMTU433_RS15400	COG0697	spore germination
IOMTU433_RS15435	COG0477	Major facilitator Superfamily
IOMTU433_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS15495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IOMTU433_RS15530	COG0583	DNA-binding transcription factor activity
IOMTU433_RS15545	COG0583	DNA-binding transcription factor activity
IOMTU433_RS15550	COG1053	succinate dehydrogenase
IOMTU433_RS15560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IOMTU433_RS15565	COG2814	Major facilitator Superfamily
IOMTU433_RS15570	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS15575	COG0583	DNA-binding transcription factor activity
IOMTU433_RS15580	COG1063	alcohol dehydrogenase
IOMTU433_RS15610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IOMTU433_RS15615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IOMTU433_RS15620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOMTU433_RS15640	COG2132	Multicopper oxidase
IOMTU433_RS15650	COG0561	phosphatase activity
IOMTU433_RS15655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOMTU433_RS15665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IOMTU433_RS15680	COG1214	PFAM Peptidase M22, glycoprotease
IOMTU433_RS15730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOMTU433_RS15740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IOMTU433_RS15745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOMTU433_RS15750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOMTU433_RS15810	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IOMTU433_RS15820	COG1846	Transcriptional regulator
IOMTU433_RS15825	COG1764	response to oxidative stress
IOMTU433_RS15865	COG0037	tRNA processing
IOMTU433_RS15875	COG0248	Ppx GppA phosphatase
IOMTU433_RS15900	COG0072	phenylalanine-tRNA ligase activity
IOMTU433_RS15940	COG1238	metal cluster binding
IOMTU433_RS15945	COG0625	glutathione transferase activity
IOMTU433_RS15960	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS15965	COG3028	Belongs to the UPF0307 family
IOMTU433_RS15970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IOMTU433_RS15990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOMTU433_RS15995	COG0617	tRNA 3'-terminal CCA addition
IOMTU433_RS16000	COG1555	photosystem II stabilization
IOMTU433_RS16005	COG3956	TIGRFAM MazG family protein
IOMTU433_RS16015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOMTU433_RS16035	COG0784	Response regulator, receiver
IOMTU433_RS16035	COG2205	protein histidine kinase activity
IOMTU433_RS16035	COG5002	protein histidine kinase activity
IOMTU433_RS16040	COG1024	Enoyl-CoA hydratase
IOMTU433_RS16045	COG2084	Dehydrogenase
IOMTU433_RS16050	COG3622	Belongs to the hyi family
IOMTU433_RS16080	COG0697	spore germination
IOMTU433_RS16090	COG2814	Major facilitator Superfamily
IOMTU433_RS16110	COG2132	Multicopper oxidase
IOMTU433_RS16125	COG2205	protein histidine kinase activity
IOMTU433_RS16210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOMTU433_RS16220	COG0583	DNA-binding transcription factor activity
IOMTU433_RS16225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IOMTU433_RS16235	COG0084	hydrolase, TatD family'
IOMTU433_RS16250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IOMTU433_RS16285	COG0440	acetolactate synthase activity
IOMTU433_RS16290	COG0028	Belongs to the TPP enzyme family
IOMTU433_RS16315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOMTU433_RS16320	COG0577	efflux transmembrane transporter activity
IOMTU433_RS16320	COG1136	(ABC) transporter
IOMTU433_RS16325	COG1538	Outer membrane efflux protein
IOMTU433_RS16340	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IOMTU433_RS16345	COG1162	GTPase activity
IOMTU433_RS16355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IOMTU433_RS16395	COG1426	Protein conserved in bacteria
IOMTU433_RS16430	COG0793	Belongs to the peptidase S41A family
IOMTU433_RS16445	COG2267	carboxylic ester hydrolase activity
IOMTU433_RS16455	COG1012	belongs to the aldehyde dehydrogenase family
IOMTU433_RS16460	COG3265	gluconokinase activity
IOMTU433_RS16470	COG0800	Aldolase
IOMTU433_RS16480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IOMTU433_RS16485	COG0280	phosphate acetyltransferase
IOMTU433_RS16485	COG0857	belongs to the CobB CobQ family
IOMTU433_RS16490	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IOMTU433_RS16490	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IOMTU433_RS16510	COG0740	serine-type endopeptidase activity
IOMTU433_RS16520	COG4774	siderophore transport
IOMTU433_RS16530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOMTU433_RS16540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IOMTU433_RS16540	COG2813	Specifically methylates the guanine in position
IOMTU433_RS16640	COG0788	formyltetrahydrofolate deformylase activity
IOMTU433_RS16665	COG4651	solute:proton antiporter activity
IOMTU433_RS16665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOMTU433_RS16680	COG0724	RNA recognition motif
IOMTU433_RS16685	COG0210	DNA helicase
IOMTU433_RS16710	COG1733	regulation of RNA biosynthetic process
IOMTU433_RS16720	COG2900	Belongs to the SlyX family
IOMTU433_RS16725	COG0488	(ABC) transporter
IOMTU433_RS16730	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS16735	COG1560	Kdo2-lipid A biosynthetic process
IOMTU433_RS16745	COG1301	dicarboxylic acid transport
IOMTU433_RS16800	COG0473	3-isopropylmalate dehydrogenase activity
IOMTU433_RS16865	COG0583	DNA-binding transcription factor activity
IOMTU433_RS16875	COG0625	glutathione transferase activity
IOMTU433_RS16880	COG2378	regulation of single-species biofilm formation
IOMTU433_RS16885	COG0546	phosphoglycolate phosphatase activity
IOMTU433_RS16895	COG1530	ribonuclease E activity
IOMTU433_RS16900	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS16915	COG0583	DNA-binding transcription factor activity
IOMTU433_RS16920	COG4221	oxidoreductase activity
IOMTU433_RS16925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOMTU433_RS16935	COG0534	Mate efflux family protein
IOMTU433_RS16950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IOMTU433_RS16975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOMTU433_RS16975	COG0493	'glutamate synthase
IOMTU433_RS16985	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IOMTU433_RS16990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOMTU433_RS17005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOMTU433_RS17015	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
IOMTU433_RS17015	COG0644	oxidoreductase
IOMTU433_RS17025	COG0425	Belongs to the sulfur carrier protein TusA family
IOMTU433_RS17030	COG4535	Mg2 and Co2 transporter CorC
IOMTU433_RS17040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOMTU433_RS17060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOMTU433_RS17065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOMTU433_RS17065	COG0475	glutathione-regulated potassium exporter activity
IOMTU433_RS17080	COG0484	heat shock protein binding
IOMTU433_RS17085	COG0789	Transcriptional regulator
IOMTU433_RS17090	COG0598	Magnesium transport protein CorA
IOMTU433_RS17105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IOMTU433_RS17110	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOMTU433_RS17115	COG1074	ATP-dependent DNA helicase activity
IOMTU433_RS17120	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IOMTU433_RS17140	COG2226	methyltransferase
IOMTU433_RS17160	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOMTU433_RS17175	COG2111	Na H antiporter
IOMTU433_RS17175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOMTU433_RS17180	COG1006	Multisubunit Na H antiporter MnhC subunit
IOMTU433_RS17185	COG0651	ATP synthesis coupled electron transport
IOMTU433_RS17190	COG1863	multisubunit Na H antiporter MnhE subunit
IOMTU433_RS17195	COG2212	antiporter activity
IOMTU433_RS17200	COG1320	monovalent cation:proton antiporter activity
IOMTU433_RS17215	COG0195	Participates in both transcription termination and antitermination
IOMTU433_RS17265	COG0237	dephospho-CoA kinase activity
IOMTU433_RS17275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOMTU433_RS17290	COG0497	DNA recombination
IOMTU433_RS17300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOMTU433_RS17330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOMTU433_RS17330	COG2169	Transcriptional regulator
IOMTU433_RS17335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IOMTU433_RS17390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOMTU433_RS17405	COG0326	Molecular chaperone. Has ATPase activity
IOMTU433_RS17420	COG2056	Na+-H+ antiporter family
IOMTU433_RS17425	COG0596	Alpha beta hydrolase
IOMTU433_RS17520	COG0546	phosphoglycolate phosphatase activity
IOMTU433_RS17525	COG1716	ATPase activity
IOMTU433_RS17570	COG0181	hydroxymethylbilane synthase activity
IOMTU433_RS17580	COG3275	phosphorelay sensor kinase activity
IOMTU433_RS17600	COG1538	Outer membrane efflux protein
IOMTU433_RS17605	COG0697	spore germination
IOMTU433_RS17630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IOMTU433_RS17635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOMTU433_RS17640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOMTU433_RS17645	COG0772	Belongs to the SEDS family
IOMTU433_RS17670	COG4974	Belongs to the 'phage' integrase family
IOMTU433_RS17675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_RS17685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOMTU433_RS17695	COG2197	response regulator
IOMTU433_RS17710	COG0793	Belongs to the peptidase S41A family
IOMTU433_RS17715	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOMTU433_RS17720	COG0795	lipopolysaccharide-transporting ATPase activity
IOMTU433_RS17760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOMTU433_RS17760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOMTU433_RS17770	COG0004	ammonium transporteR
IOMTU433_RS17775	COG0347	Belongs to the P(II) protein family
IOMTU433_RS17785	COG0606	chelatase, subunit chli
IOMTU433_RS17815	COG1061	Type III restriction enzyme res subunit
IOMTU433_RS17835	COG0659	secondary active sulfate transmembrane transporter activity
IOMTU433_RS17840	COG0589	response to stress
IOMTU433_RS17880	COG0606	chelatase, subunit chli
IOMTU433_RS17885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IOMTU433_RS17895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOMTU433_RS17910	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOMTU433_RS17925	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS17935	COG0477	Major facilitator Superfamily
IOMTU433_RS17940	COG2860	membrane
IOMTU433_RS17950	COG1253	flavin adenine dinucleotide binding
IOMTU433_RS17970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOMTU433_RS18005	COG0655	NAD(P)H dehydrogenase (quinone) activity
IOMTU433_RS18015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOMTU433_RS18050	COG1309	transcriptional regulator
IOMTU433_RS18085	COG0758	DNA mediated transformation
IOMTU433_RS18095	COG0697	spore germination
IOMTU433_RS18100	COG1309	transcriptional regulator
IOMTU433_RS18115	COG0386	Belongs to the glutathione peroxidase family
IOMTU433_RS18180	COG1121	(ABC) transporter
IOMTU433_RS18185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOMTU433_RS18190	COG1280	lysine exporter protein (LysE YggA)
IOMTU433_RS18195	COG2837	iron assimilation
IOMTU433_RS18200	COG0281	malic enzyme
IOMTU433_RS18245	COG0519	Catalyzes the synthesis of GMP from XMP
IOMTU433_RS18245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOMTU433_RS18250	COG4399	Belongs to the UPF0754 family
IOMTU433_RS18255	COG2259	Doxx family
IOMTU433_RS18260	COG0586	Pfam SNARE associated Golgi protein
IOMTU433_RS18275	COG1192	Involved in chromosome partitioning
IOMTU433_RS18285	COG0271	Belongs to the BolA IbaG family
IOMTU433_RS18325	COG0300	oxidoreductase activity
IOMTU433_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS18325	COG0318	PFAM AMP-dependent synthetase and ligase
IOMTU433_RS18325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IOMTU433_RS18325	COG3321	synthase
IOMTU433_RS18330	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS18340	COG2197	response regulator
IOMTU433_RS18350	COG3916	Acyl-homoserine-lactone synthase
IOMTU433_RS18355	COG0477	Major facilitator Superfamily
IOMTU433_RS18360	COG1024	Enoyl-CoA hydratase
IOMTU433_RS18365	COG1024	Enoyl-CoA hydratase
IOMTU433_RS18370	COG1960	acyl-CoA dehydrogenase activity
IOMTU433_RS18375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IOMTU433_RS18395	COG1113	amino acid transport
IOMTU433_RS18400	COG1113	amino acid transport
IOMTU433_RS18405	COG0251	oxidation-reduction process
IOMTU433_RS18445	COG0564	pseudouridine synthase activity
IOMTU433_RS18490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IOMTU433_RS18505	COG1802	Transcriptional regulator
IOMTU433_RS18510	COG1448	Aminotransferase
IOMTU433_RS18515	COG0277	FAD linked oxidase domain protein
IOMTU433_RS18525	COG2186	Transcriptional regulator
IOMTU433_RS18535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_RS18545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOMTU433_RS18560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IOMTU433_RS18565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOMTU433_RS18570	COG1216	Glycosyl transferase, family 2
IOMTU433_RS18590	COG0438	transferase activity, transferring glycosyl groups
IOMTU433_RS18620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IOMTU433_RS18650	COG0728	peptidoglycan biosynthetic process
IOMTU433_RS18655	COG3023	N-Acetylmuramoyl-L-alanine amidase
IOMTU433_RS18710	COG0546	phosphoglycolate phosphatase activity
IOMTU433_RS18715	COG1028	Short-chain dehydrogenase reductase Sdr
IOMTU433_RS18735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_RS18740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IOMTU433_RS18745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IOMTU433_RS18750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IOMTU433_RS18755	COG1116	anion transmembrane transporter activity
IOMTU433_RS18760	COG1309	transcriptional regulator
IOMTU433_RS18765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOMTU433_RS18775	COG0196	riboflavin kinase activity
IOMTU433_RS18780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOMTU433_RS18790	COG1047	Peptidyl-prolyl cis-trans
IOMTU433_RS18830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOMTU433_RS18835	COG0657	acetylesterase activity
IOMTU433_RS18855	COG0583	DNA-binding transcription factor activity
IOMTU433_RS18885	COG2951	lytic endotransglycosylase activity
IOMTU433_RS18890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IOMTU433_RS18910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOMTU433_RS18920	COG0671	phosphoesterase, PA-phosphatase related
IOMTU433_RS18925	COG0861	Integral membrane protein TerC family
IOMTU433_RS18935	COG0754	glutathionylspermidine amidase activity
IOMTU433_RS18945	COG0402	S-adenosylhomocysteine deaminase activity
IOMTU433_RS18965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IOMTU433_RS18970	COG1230	cation diffusion facilitator family transporter
IOMTU433_RS19005	COG3173	Aminoglycoside phosphotransferase
IOMTU433_RS19010	COG0488	(ABC) transporter
IOMTU433_RS19055	COG1132	(ABC) transporter
IOMTU433_RS19160	COG1192	Involved in chromosome partitioning
IOMTU433_RS19175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOMTU433_RS19215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOMTU433_RS19370	COG1373	ATPase (AAA superfamily
IOMTU433_RS19405	COG1309	transcriptional regulator
IOMTU433_RS19435	COG0633	Ferredoxin
IOMTU433_RS19440	COG2207	Transcriptional regulator
IOMTU433_RS19605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOMTU433_RS19655	COG1192	Involved in chromosome partitioning
IOMTU433_RS19665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IOMTU433_RS19705	COG0739	heme binding
IOMTU433_RS19940	COG0501	Belongs to the peptidase M48B family
IOMTU433_RS19975	COG4973	Belongs to the 'phage' integrase family. XerC subfamily