locus-tag	class	description
J5P21_RS00015	COG0347	Belongs to the P(II) protein family
J5P21_RS00020	COG0004	ammonium transporteR
J5P21_RS00030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5P21_RS00030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
J5P21_RS00070	COG0795	lipopolysaccharide-transporting ATPase activity
J5P21_RS00075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
J5P21_RS00080	COG0793	Belongs to the peptidase S41A family
J5P21_RS00095	COG2197	response regulator
J5P21_RS00105	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J5P21_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5P21_RS00120	COG4974	Belongs to the 'phage' integrase family
J5P21_RS00145	COG0772	Belongs to the SEDS family
J5P21_RS00150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5P21_RS00155	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
J5P21_RS00160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5P21_RS00185	COG0697	spore germination
J5P21_RS00190	COG1538	Outer membrane efflux protein
J5P21_RS00210	COG3275	phosphorelay sensor kinase activity
J5P21_RS00220	COG0181	hydroxymethylbilane synthase activity
J5P21_RS00265	COG1716	ATPase activity
J5P21_RS00270	COG0546	phosphoglycolate phosphatase activity
J5P21_RS00365	COG0596	Alpha beta hydrolase
J5P21_RS00370	COG2056	Na+-H+ antiporter family
J5P21_RS00385	COG0326	Molecular chaperone. Has ATPase activity
J5P21_RS00400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
J5P21_RS00465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J5P21_RS00470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5P21_RS00470	COG2169	Transcriptional regulator
J5P21_RS00500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J5P21_RS00510	COG0497	DNA recombination
J5P21_RS00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5P21_RS00535	COG0237	dephospho-CoA kinase activity
J5P21_RS00585	COG0195	Participates in both transcription termination and antitermination
J5P21_RS00600	COG1320	monovalent cation:proton antiporter activity
J5P21_RS00605	COG2212	antiporter activity
J5P21_RS00610	COG1863	multisubunit Na H antiporter MnhE subunit
J5P21_RS00615	COG0651	ATP synthesis coupled electron transport
J5P21_RS00620	COG1006	Multisubunit Na H antiporter MnhC subunit
J5P21_RS00625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5P21_RS00625	COG2111	Na H antiporter
J5P21_RS00640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
J5P21_RS00660	COG2226	methyltransferase
J5P21_RS00680	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
J5P21_RS00685	COG1074	ATP-dependent DNA helicase activity
J5P21_RS00690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5P21_RS00695	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J5P21_RS00710	COG0598	Magnesium transport protein CorA
J5P21_RS00715	COG0789	Transcriptional regulator
J5P21_RS00720	COG0484	heat shock protein binding
J5P21_RS00735	COG0475	glutathione-regulated potassium exporter activity
J5P21_RS00735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5P21_RS00740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J5P21_RS00760	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5P21_RS00770	COG4535	Mg2 and Co2 transporter CorC
J5P21_RS00775	COG0425	Belongs to the sulfur carrier protein TusA family
J5P21_RS00785	COG0644	oxidoreductase
J5P21_RS00785	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
J5P21_RS00795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5P21_RS00810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5P21_RS00815	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
J5P21_RS00825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5P21_RS00825	COG0493	'glutamate synthase
J5P21_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
J5P21_RS00865	COG0534	Mate efflux family protein
J5P21_RS00875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J5P21_RS00880	COG4221	oxidoreductase activity
J5P21_RS00885	COG0583	DNA-binding transcription factor activity
J5P21_RS00900	COG0318	PFAM AMP-dependent synthetase and ligase
J5P21_RS00905	COG1530	ribonuclease E activity
J5P21_RS00915	COG0546	phosphoglycolate phosphatase activity
J5P21_RS00920	COG2378	regulation of single-species biofilm formation
J5P21_RS00925	COG0625	glutathione transferase activity
J5P21_RS01010	COG0473	3-isopropylmalate dehydrogenase activity
J5P21_RS01065	COG1301	dicarboxylic acid transport
J5P21_RS01075	COG1560	Kdo2-lipid A biosynthetic process
J5P21_RS01080	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS01085	COG0488	(ABC) transporter
J5P21_RS01090	COG2900	Belongs to the SlyX family
J5P21_RS01100	COG1733	regulation of RNA biosynthetic process
J5P21_RS01125	COG0210	DNA helicase
J5P21_RS01130	COG0724	RNA recognition motif
J5P21_RS01150	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
J5P21_RS01150	COG4651	solute:proton antiporter activity
J5P21_RS01175	COG0788	formyltetrahydrofolate deformylase activity
J5P21_RS01275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5P21_RS01275	COG2813	Specifically methylates the guanine in position
J5P21_RS01285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5P21_RS01295	COG4774	siderophore transport
J5P21_RS01305	COG0740	serine-type endopeptidase activity
J5P21_RS01325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
J5P21_RS01325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
J5P21_RS01330	COG0280	phosphate acetyltransferase
J5P21_RS01330	COG0857	belongs to the CobB CobQ family
J5P21_RS01335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J5P21_RS01345	COG0800	Aldolase
J5P21_RS01355	COG3265	gluconokinase activity
J5P21_RS01360	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS01370	COG2267	carboxylic ester hydrolase activity
J5P21_RS01385	COG0793	Belongs to the peptidase S41A family
J5P21_RS01420	COG1426	Protein conserved in bacteria
J5P21_RS01460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J5P21_RS01470	COG1162	GTPase activity
J5P21_RS01475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
J5P21_RS01490	COG1538	Outer membrane efflux protein
J5P21_RS01495	COG0577	efflux transmembrane transporter activity
J5P21_RS01495	COG1136	(ABC) transporter
J5P21_RS01500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS01525	COG0028	Belongs to the TPP enzyme family
J5P21_RS01530	COG0440	acetolactate synthase activity
J5P21_RS01565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J5P21_RS01580	COG0084	hydrolase, TatD family'
J5P21_RS01590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J5P21_RS01600	COG0583	DNA-binding transcription factor activity
J5P21_RS01610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5P21_RS01700	COG2205	protein histidine kinase activity
J5P21_RS01715	COG2132	Multicopper oxidase
J5P21_RS01735	COG2814	Major facilitator Superfamily
J5P21_RS01745	COG0697	spore germination
J5P21_RS01775	COG3622	Belongs to the hyi family
J5P21_RS01780	COG2084	Dehydrogenase
J5P21_RS01785	COG1024	Enoyl-CoA hydratase
J5P21_RS01790	COG0784	Response regulator, receiver
J5P21_RS01790	COG2205	protein histidine kinase activity
J5P21_RS01790	COG5002	protein histidine kinase activity
J5P21_RS01810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5P21_RS01820	COG3956	TIGRFAM MazG family protein
J5P21_RS01825	COG1555	photosystem II stabilization
J5P21_RS01830	COG0617	tRNA 3'-terminal CCA addition
J5P21_RS01835	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J5P21_RS01855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5P21_RS01860	COG3028	Belongs to the UPF0307 family
J5P21_RS01865	COG0318	PFAM AMP-dependent synthetase and ligase
J5P21_RS01880	COG0625	glutathione transferase activity
J5P21_RS01885	COG1238	metal cluster binding
J5P21_RS01925	COG0072	phenylalanine-tRNA ligase activity
J5P21_RS01955	COG0248	Ppx GppA phosphatase
J5P21_RS01965	COG0037	tRNA processing
J5P21_RS02005	COG1764	response to oxidative stress
J5P21_RS02010	COG1846	Transcriptional regulator
J5P21_RS02020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5P21_RS02080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J5P21_RS02085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J5P21_RS02090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J5P21_RS02100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
J5P21_RS02160	COG1214	PFAM Peptidase M22, glycoprotease
J5P21_RS02175	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
J5P21_RS02185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J5P21_RS02190	COG0561	phosphatase activity
J5P21_RS02200	COG2132	Multicopper oxidase
J5P21_RS02220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J5P21_RS02225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J5P21_RS02230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J5P21_RS02260	COG1063	alcohol dehydrogenase
J5P21_RS02265	COG0583	DNA-binding transcription factor activity
J5P21_RS02270	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS02275	COG2814	Major facilitator Superfamily
J5P21_RS02280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5P21_RS02290	COG1053	succinate dehydrogenase
J5P21_RS02295	COG0583	DNA-binding transcription factor activity
J5P21_RS02310	COG0583	DNA-binding transcription factor activity
J5P21_RS02345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS02390	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS02400	COG0477	Major facilitator Superfamily
J5P21_RS02435	COG0697	spore germination
J5P21_RS02440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J5P21_RS02460	COG0745	RESPONSE REGULATOR receiver
J5P21_RS02500	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
J5P21_RS02530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
J5P21_RS02535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
J5P21_RS02560	COG0583	DNA-binding transcription factor activity
J5P21_RS02580	COG0668	transmembrane transport
J5P21_RS02590	COG2081	HI0933 family
J5P21_RS02595	COG2515	1-aminocyclopropane-1-carboxylate deaminase
J5P21_RS02625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5P21_RS02625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J5P21_RS02635	COG0489	protein tyrosine kinase activity
J5P21_RS02685	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J5P21_RS02695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J5P21_RS02710	COG0730	response to heat
J5P21_RS02720	COG1196	nuclear chromosome segregation
J5P21_RS02740	COG2223	nitrite transmembrane transporter activity
J5P21_RS02745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
J5P21_RS02750	COG1877	trehalose-phosphatase activity
J5P21_RS02755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5P21_RS02755	COG2226	methyltransferase
J5P21_RS02755	COG0596	Alpha beta hydrolase
J5P21_RS02770	COG4106	trans-aconitate 2-methyltransferase activity
J5P21_RS02785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J5P21_RS02790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J5P21_RS02795	COG0009	L-threonylcarbamoyladenylate synthase
J5P21_RS02800	COG3101	peptidyl-lysine hydroxylation
J5P21_RS02805	COG1399	metal-binding, possibly nucleic acid-binding protein
J5P21_RS02830	COG1652	LysM domain
J5P21_RS02835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5P21_RS02835	COG0352	thiamine-phosphate diphosphorylase activity
J5P21_RS02835	COG0351	phosphomethylpyrimidine kinase
J5P21_RS02845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
J5P21_RS02875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5P21_RS02905	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
J5P21_RS02920	COG0358	DNA primase activity
J5P21_RS02930	COG0564	pseudouridine synthase activity
J5P21_RS02955	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5P21_RS02975	COG0583	DNA-binding transcription factor activity
J5P21_RS02980	COG0473	3-isopropylmalate dehydrogenase activity
J5P21_RS02990	COG0657	acetylesterase activity
J5P21_RS03000	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS03020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
J5P21_RS03020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J5P21_RS03035	COG1981	membrane
J5P21_RS03080	COG0456	acetyltransferase
J5P21_RS03090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
J5P21_RS03095	COG0492	ferredoxin-NADP+ reductase activity
J5P21_RS03100	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J5P21_RS03100	COG1674	ftsk spoiiie
J5P21_RS03105	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS03120	COG2894	cell division
J5P21_RS03135	COG0204	Acyl-transferase
J5P21_RS03140	COG2885	chlorophyll binding
J5P21_RS03145	COG0210	DNA helicase
J5P21_RS03155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5P21_RS03170	COG0121	glutamine amidotransferase
J5P21_RS03190	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
J5P21_RS03195	COG0735	belongs to the Fur family
J5P21_RS03220	COG0420	3'-5' exonuclease activity
J5P21_RS03240	COG1090	epimerase
J5P21_RS03255	COG2050	protein possibly involved in aromatic compounds catabolism
J5P21_RS03265	COG2814	Major facilitator Superfamily
J5P21_RS03270	COG0405	Gamma-glutamyltransferase
J5P21_RS03330	COG0477	Major facilitator Superfamily
J5P21_RS03335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5P21_RS03345	COG1595	DNA-templated transcription, initiation
J5P21_RS03400	COG0531	amino acid
J5P21_RS03405	COG2040	homocysteine
J5P21_RS03430	COG1309	transcriptional regulator
J5P21_RS03435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5P21_RS03440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5P21_RS03450	COG1607	acyl-coa hydrolase
J5P21_RS03460	COG0523	cobalamin synthesis protein
J5P21_RS03470	COG4681	YaeQ
J5P21_RS03480	COG0726	polysaccharide deacetylase
J5P21_RS03480	COG1649	PFAM Uncharacterised BCR, COG1649
J5P21_RS03485	COG1215	transferase activity, transferring glycosyl groups
J5P21_RS03495	COG1024	Enoyl-CoA hydratase
J5P21_RS03510	COG1414	Transcriptional regulator
J5P21_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS03540	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5P21_RS03545	COG2271	Major facilitator Superfamily
J5P21_RS03555	COG2267	carboxylic ester hydrolase activity
J5P21_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS03575	COG0028	Belongs to the TPP enzyme family
J5P21_RS03585	COG0477	Major facilitator Superfamily
J5P21_RS03590	COG0242	peptide deformylase activity
J5P21_RS03595	COG2066	Belongs to the glutaminase family
J5P21_RS03600	COG2207	Transcriptional regulator
J5P21_RS03605	COG2223	nitrite transmembrane transporter activity
J5P21_RS03620	COG0583	DNA-binding transcription factor activity
J5P21_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS03630	COG2271	Major facilitator Superfamily
J5P21_RS03635	COG3959	Transketolase, thiamine diphosphate binding domain
J5P21_RS03640	COG3958	Transketolase
J5P21_RS03650	COG0306	phosphate transporter
J5P21_RS03670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5P21_RS03715	COG4181	ATPase activity
J5P21_RS03720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
J5P21_RS03750	COG0583	DNA-binding transcription factor activity
J5P21_RS03760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5P21_RS03765	COG1773	rubredoxin
J5P21_RS03815	COG2851	Citrate transporter
J5P21_RS03820	COG1253	flavin adenine dinucleotide binding
J5P21_RS03860	COG0804	urea catabolic process
J5P21_RS03870	COG0830	nickel cation binding
J5P21_RS03885	COG0742	ribosomal rna small subunit methyltransferase
J5P21_RS03890	COG0768	penicillin binding
J5P21_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J5P21_RS03920	COG2878	Part of a membrane complex involved in electron transport
J5P21_RS03925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5P21_RS03935	COG3384	dioxygenase
J5P21_RS03960	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J5P21_RS04050	COG0270	DNA (cytosine-5-)-methyltransferase activity
J5P21_RS04210	COG1598	PFAM Uncharacterised protein family UPF0150
J5P21_RS04225	COG0739	heme binding
J5P21_RS04275	COG2194	sulfuric ester hydrolase activity
J5P21_RS04310	COG0006	proline dipeptidase activity
J5P21_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5P21_RS04320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5P21_RS04340	COG1279	arginine transmembrane transporter activity
J5P21_RS04345	COG0583	DNA-binding transcription factor activity
J5P21_RS04385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5P21_RS04390	COG0741	lytic transglycosylase activity
J5P21_RS04390	COG0741	lytic transglycosylase activity
J5P21_RS04390	COG1388	LysM domain
J5P21_RS04390	COG1388	LysM domain
J5P21_RS04400	COG4174	ABC transporter (Permease)
J5P21_RS04405	COG4239	(ABC) transporter, permease
J5P21_RS04410	COG4172	Belongs to the ABC transporter superfamily
J5P21_RS04430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5P21_RS04440	COG2203	Gaf domain
J5P21_RS04440	COG3706	GGDEF domain
J5P21_RS04440	COG4251	negative regulation of phosphorylation
J5P21_RS04440	COG5001	Diguanylate cyclase
J5P21_RS04455	COG1902	pentaerythritol trinitrate reductase activity
J5P21_RS04455	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5P21_RS04470	COG4269	membrane
J5P21_RS04495	COG3209	COG3209 Rhs family protein
J5P21_RS04525	COG1113	amino acid transport
J5P21_RS04535	COG0531	amino acid
J5P21_RS04555	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS04575	COG1113	amino acid transport
J5P21_RS04610	COG0697	spore germination
J5P21_RS04615	COG2721	sulfolactate sulfo-lyase activity
J5P21_RS04620	COG2271	Major facilitator Superfamily
J5P21_RS04625	COG4948	Mandelate Racemase Muconate Lactonizing
J5P21_RS04635	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS04640	COG2186	Transcriptional regulator
J5P21_RS04665	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS04675	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS04680	COG1024	Enoyl-CoA hydratase
J5P21_RS04685	COG2814	Major facilitator Superfamily
J5P21_RS04700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5P21_RS04715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
J5P21_RS04760	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
J5P21_RS04765	COG2072	flavoprotein involved in K transport
J5P21_RS04770	COG0300	oxidoreductase activity
J5P21_RS04780	COG1309	transcriptional regulator
J5P21_RS04785	COG1741	Belongs to the pirin family
J5P21_RS04800	COG2072	flavoprotein involved in K transport
J5P21_RS04810	COG2252	PERMEase
J5P21_RS04815	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J5P21_RS04820	COG3038	cytochrome b561
J5P21_RS04830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J5P21_RS04840	COG0527	aspartate kinase activity
J5P21_RS04880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J5P21_RS04975	COG1484	DNA-dependent DNA replication
J5P21_RS05025	COG3755	Protein conserved in bacteria
J5P21_RS05175	COG2026	Addiction module toxin, RelE StbE family
J5P21_RS05215	COG0592	DNA-directed DNA polymerase activity
J5P21_RS05280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5P21_RS05300	COG0582	viral genome integration into host DNA
J5P21_RS05310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J5P21_RS05325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J5P21_RS05340	COG0667	Aldo Keto reductase
J5P21_RS05355	COG1765	OsmC-like protein
J5P21_RS05370	COG0542	response to heat
J5P21_RS05405	COG2885	chlorophyll binding
J5P21_RS05415	COG0625	glutathione transferase activity
J5P21_RS05420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J5P21_RS05440	COG3634	alkyl hydroperoxide reductase activity
J5P21_RS05450	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
J5P21_RS05460	COG0450	alkyl hydroperoxide reductase
J5P21_RS05465	COG1643	Atp-dependent helicase
J5P21_RS05480	COG2814	Major facilitator Superfamily
J5P21_RS05485	COG3135	benzoate transporter
J5P21_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS05495	COG0633	Ferredoxin
J5P21_RS05495	COG0543	2 iron, 2 sulfur cluster binding
J5P21_RS05500	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
J5P21_RS05505	COG4638	Rieske (2fe-2S)
J5P21_RS05510	COG0583	DNA-binding transcription factor activity
J5P21_RS05520	COG2871	sodium ion transport
J5P21_RS05600	COG1570	exodeoxyribonuclease VII activity
J5P21_RS05630	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS05635	COG1278	Cold shock
J5P21_RS05670	COG2814	Major facilitator Superfamily
J5P21_RS05715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J5P21_RS05715	COG0517	IMP dehydrogenase activity
J5P21_RS05720	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
J5P21_RS05730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
J5P21_RS05735	COG1137	ATPase activity
J5P21_RS05740	COG1538	Outer membrane efflux protein
J5P21_RS05770	COG4122	O-methyltransferase activity
J5P21_RS05780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
J5P21_RS05795	COG1522	sequence-specific DNA binding
J5P21_RS05800	COG5006	permease, DMT superfamily
J5P21_RS05810	COG1560	Kdo2-lipid A biosynthetic process
J5P21_RS05820	COG2814	Major facilitator Superfamily
J5P21_RS05840	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5P21_RS05905	COG0583	DNA-binding transcription factor activity
J5P21_RS05910	COG1914	H( )-stimulated, divalent metal cation uptake system
J5P21_RS05930	COG4770	biotin carboxylase activity
J5P21_RS05940	COG0038	chloride channel
J5P21_RS05945	COG2831	hemolysin activation secretion protein
J5P21_RS05950	COG3210	domain, Protein
J5P21_RS05965	COG1309	transcriptional regulator
J5P21_RS05975	COG1063	alcohol dehydrogenase
J5P21_RS05990	COG0439	Biotin carboxylase
J5P21_RS05995	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5P21_RS06000	COG1733	regulation of RNA biosynthetic process
J5P21_RS06010	COG0864	Transcriptional regulator
J5P21_RS06025	COG1116	anion transmembrane transporter activity
J5P21_RS06140	COG0590	tRNA wobble adenosine to inosine editing
J5P21_RS06145	COG2807	transmembrane transport
J5P21_RS06160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J5P21_RS06170	COG0789	Transcriptional regulator
J5P21_RS06180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5P21_RS06200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J5P21_RS06225	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS06230	COG0531	amino acid
J5P21_RS06235	COG1760	l-serine dehydratase
J5P21_RS06240	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS06240	COG2030	dehydratase
J5P21_RS06245	COG3396	Phenylacetate-CoA oxygenase
J5P21_RS06250	COG3460	Phenylacetate-CoA oxygenase
J5P21_RS06255	COG3396	Phenylacetate-CoA oxygenase
J5P21_RS06260	COG2151	metal-sulfur cluster biosynthetic enzyme
J5P21_RS06265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5P21_RS06270	COG1024	Enoyl-CoA hydratase
J5P21_RS06275	COG1024	Enoyl-CoA hydratase
J5P21_RS06295	COG0183	Belongs to the thiolase family
J5P21_RS06300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
J5P21_RS06305	COG3327	negative regulation of DNA-templated transcription, initiation
J5P21_RS06315	COG2050	protein possibly involved in aromatic compounds catabolism
J5P21_RS06355	COG2207	Transcriptional regulator
J5P21_RS06370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
J5P21_RS06375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J5P21_RS06380	COG2271	Major facilitator Superfamily
J5P21_RS06385	COG0753	catalase activity
J5P21_RS06390	COG3038	cytochrome b561
J5P21_RS06410	COG2267	carboxylic ester hydrolase activity
J5P21_RS06415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5P21_RS06425	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS06435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J5P21_RS06445	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS06450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5P21_RS06455	COG0583	DNA-binding transcription factor activity
J5P21_RS06465	COG1414	Transcriptional regulator
J5P21_RS06470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5P21_RS06480	COG1840	ABC-type Fe3 transport system, periplasmic component
J5P21_RS06500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
J5P21_RS06505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5P21_RS06510	COG2814	Major facilitator Superfamily
J5P21_RS06515	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS06530	COG1024	Enoyl-CoA hydratase
J5P21_RS06540	COG2814	Major facilitator Superfamily
J5P21_RS06550	COG0183	Belongs to the thiolase family
J5P21_RS06555	COG1250	3-hydroxyacyl-CoA dehydrogenase
J5P21_RS06560	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS06565	COG1024	Enoyl-CoA hydratase
J5P21_RS06570	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS06575	COG2814	Major facilitator Superfamily
J5P21_RS06580	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J5P21_RS06585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5P21_RS06595	COG2814	Major facilitator Superfamily
J5P21_RS06605	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS06620	COG0583	DNA-binding transcription factor activity
J5P21_RS06630	COG4770	biotin carboxylase activity
J5P21_RS06635	COG1024	Enoyl-CoA hydratase
J5P21_RS06640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5P21_RS06645	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS06650	COG1309	transcriptional regulator
J5P21_RS06655	COG0318	PFAM AMP-dependent synthetase and ligase
J5P21_RS06675	COG0583	DNA-binding transcription factor activity
J5P21_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS06745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J5P21_RS06765	COG0784	Response regulator, receiver
J5P21_RS06765	COG2205	protein histidine kinase activity
J5P21_RS06785	COG0765	amino acid transport
J5P21_RS06790	COG0765	amino acid transport
J5P21_RS06800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5P21_RS06805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J5P21_RS06815	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS06820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J5P21_RS06825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5P21_RS06830	COG1045	serine acetyltransferase
J5P21_RS06845	COG0583	DNA-binding transcription factor activity
J5P21_RS06850	COG0625	glutathione transferase activity
J5P21_RS06855	COG0625	glutathione transferase activity
J5P21_RS06860	COG0583	DNA-binding transcription factor activity
J5P21_RS06870	COG1346	cytolysis
J5P21_RS06890	COG2814	Major facilitator Superfamily
J5P21_RS06900	COG0583	DNA-binding transcription factor activity
J5P21_RS06910	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
J5P21_RS06915	COG3052	prosthetic group binding
J5P21_RS06935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J5P21_RS06955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5P21_RS06965	COG1294	oxidase, subunit
J5P21_RS06970	COG1271	oxidase subunit
J5P21_RS06990	COG0477	Major facilitator Superfamily
J5P21_RS07000	COG4521	taurine ABC transporter
J5P21_RS07005	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
J5P21_RS07010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5P21_RS07015	COG2175	clavaminate synthase activity
J5P21_RS07025	COG1953	Uracil, thiamine, allantoin
J5P21_RS07035	COG0583	DNA-binding transcription factor activity
J5P21_RS07045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
J5P21_RS07060	COG0640	Transcriptional regulator
J5P21_RS07065	COG0798	PFAM Bile acid sodium symporter
J5P21_RS07070	COG0583	DNA-binding transcription factor activity
J5P21_RS07085	COG3634	alkyl hydroperoxide reductase activity
J5P21_RS07120	COG1301	dicarboxylic acid transport
J5P21_RS07125	COG0436	Aminotransferase
J5P21_RS07135	COG0386	Belongs to the glutathione peroxidase family
J5P21_RS07175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
J5P21_RS07200	COG0012	GTP binding
J5P21_RS07205	COG2011	ABC-type metal ion transport system permease component
J5P21_RS07210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5P21_RS07220	COG1464	Belongs to the NlpA lipoprotein family
J5P21_RS07250	COG0765	amino acid transport
J5P21_RS07255	COG0765	amino acid transport
J5P21_RS07260	COG1126	abc transporter atp-binding protein
J5P21_RS07270	COG1522	sequence-specific DNA binding
J5P21_RS07285	COG1309	transcriptional regulator
J5P21_RS07305	COG0583	DNA-binding transcription factor activity
J5P21_RS07315	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
J5P21_RS07325	COG0697	spore germination
J5P21_RS07350	COG3121	Chaperone
J5P21_RS07355	COG3539	Fimbrial protein
J5P21_RS07380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J5P21_RS07380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J5P21_RS07425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
J5P21_RS07435	COG2353	YceI-like domain
J5P21_RS07445	COG3698	Phosphodiester glycosidase
J5P21_RS07460	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
J5P21_RS07465	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
J5P21_RS07465	COG0506	proline dehydrogenase activity
J5P21_RS07465	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
J5P21_RS07475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5P21_RS07480	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J5P21_RS07500	COG1132	(ABC) transporter
J5P21_RS07505	COG3122	Protein conserved in bacteria
J5P21_RS07510	COG3619	membrane
J5P21_RS07520	COG0640	Transcriptional regulator
J5P21_RS07530	COG2850	peptidyl-arginine hydroxylation
J5P21_RS07535	COG0424	maF-like protein
J5P21_RS07555	COG0191	fructose-bisphosphate aldolase activity
J5P21_RS07560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5P21_RS07575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J5P21_RS07585	COG1192	Involved in chromosome partitioning
J5P21_RS07590	COG1475	DNA binding
J5P21_RS07595	COG0811	peptide transport
J5P21_RS07605	COG1132	(ABC) transporter
J5P21_RS07610	COG1663	tetraacyldisaccharide 4'-kinase activity
J5P21_RS07630	COG0084	hydrolase, TatD family'
J5P21_RS07695	COG0776	regulation of translation
J5P21_RS07725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
J5P21_RS07730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
J5P21_RS07775	COG0339	signal peptide processing
J5P21_RS07785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J5P21_RS07820	COG0702	epimerase
J5P21_RS07825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5P21_RS07845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J5P21_RS07875	COG0316	Belongs to the HesB IscA family
J5P21_RS07880	COG0822	iron-sulfur transferase activity
J5P21_RS07905	COG0776	regulation of translation
J5P21_RS07910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J5P21_RS07915	COG2207	Transcriptional regulator
J5P21_RS07920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5P21_RS07925	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS07930	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS07945	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J5P21_RS07965	COG4264	IucA IucC family
J5P21_RS07970	COG4264	IucA IucC family
J5P21_RS07980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5P21_RS08010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J5P21_RS08030	COG0406	alpha-ribazole phosphatase activity
J5P21_RS08045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J5P21_RS08050	COG0730	response to heat
J5P21_RS08070	COG4773	Receptor
J5P21_RS08075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5P21_RS08090	COG1131	(ABC) transporter
J5P21_RS08095	COG0842	Transport permease protein
J5P21_RS08100	COG0842	Transport permease protein
J5P21_RS08155	COG2226	methyltransferase
J5P21_RS08180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J5P21_RS08215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5P21_RS08225	COG0133	tryptophan synthase activity
J5P21_RS08240	COG3706	GGDEF domain
J5P21_RS08255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5P21_RS08260	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
J5P21_RS08265	COG0022	dehydrogenase e1 component
J5P21_RS08270	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5P21_RS08275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5P21_RS08285	COG1063	alcohol dehydrogenase
J5P21_RS08290	COG3781	membrane
J5P21_RS08300	COG3453	Protein conserved in bacteria
J5P21_RS08300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5P21_RS08310	COG0730	response to heat
J5P21_RS08325	COG3708	Transcriptional regulator
J5P21_RS08325	COG2207	Transcriptional regulator
J5P21_RS08330	COG1733	regulation of RNA biosynthetic process
J5P21_RS08335	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
J5P21_RS08345	COG2188	Transcriptional regulator
J5P21_RS08360	COG4521	taurine ABC transporter
J5P21_RS08365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5P21_RS08385	COG0477	Major facilitator Superfamily
J5P21_RS08395	COG1027	Aspartate ammonia-lyase
J5P21_RS08410	COG0583	DNA-binding transcription factor activity
J5P21_RS08415	COG0583	DNA-binding transcription factor activity
J5P21_RS08420	COG0183	Belongs to the thiolase family
J5P21_RS08425	COG2031	fatty acid transporter
J5P21_RS08440	COG0583	DNA-binding transcription factor activity
J5P21_RS08460	COG1309	transcriptional regulator
J5P21_RS08470	COG2610	gluconate transmembrane transporter activity
J5P21_RS08475	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS08480	COG2207	Transcriptional regulator
J5P21_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS08505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS08520	COG0543	2 iron, 2 sulfur cluster binding
J5P21_RS08520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5P21_RS08525	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
J5P21_RS08530	COG4638	Rieske (2fe-2S)
J5P21_RS08540	COG0725	ABC transporter, periplasmic molybdate-binding protein
J5P21_RS08545	COG4149	molybdate abc transporter
J5P21_RS08550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
J5P21_RS08555	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS08560	COG3433	isochorismatase activity
J5P21_RS08560	COG1535	isochorismatase
J5P21_RS08625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5P21_RS08640	COG0753	catalase activity
J5P21_RS08650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J5P21_RS08675	COG3539	Fimbrial protein
J5P21_RS08730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
J5P21_RS08735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS08740	COG0745	RESPONSE REGULATOR receiver
J5P21_RS08745	COG2205	protein histidine kinase activity
J5P21_RS08755	COG2207	Transcriptional regulator
J5P21_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS08780	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
J5P21_RS08835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
J5P21_RS08885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J5P21_RS08905	COG1120	ATPase activity
J5P21_RS08910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5P21_RS08920	COG1064	alcohol dehydrogenase
J5P21_RS08935	COG2207	Transcriptional regulator
J5P21_RS08940	COG2084	Dehydrogenase
J5P21_RS08950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5P21_RS08955	COG0583	DNA-binding transcription factor activity
J5P21_RS08965	COG0129	dihydroxy-acid dehydratase activity
J5P21_RS08970	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS08985	COG1566	PFAM secretion protein HlyD family protein
J5P21_RS09015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
J5P21_RS09050	COG0583	DNA-binding transcription factor activity
J5P21_RS09075	COG2188	Transcriptional regulator
J5P21_RS09160	COG0318	PFAM AMP-dependent synthetase and ligase
J5P21_RS09170	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS09185	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS09195	COG0583	DNA-binding transcription factor activity
J5P21_RS09200	COG1309	transcriptional regulator
J5P21_RS09235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J5P21_RS09245	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5P21_RS09245	COG1902	pentaerythritol trinitrate reductase activity
J5P21_RS09260	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS09280	COG2186	Transcriptional regulator
J5P21_RS09290	COG0583	DNA-binding transcription factor activity
J5P21_RS09295	COG4948	Mandelate Racemase Muconate Lactonizing
J5P21_RS09300	COG4829	muconolactone delta-isomerase
J5P21_RS09310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J5P21_RS09315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5P21_RS09320	COG0183	Belongs to the thiolase family
J5P21_RS09325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J5P21_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS09345	COG3733	amine oxidase
J5P21_RS09355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS09375	COG4638	Rieske (2fe-2S)
J5P21_RS09395	COG0154	amidase activity
J5P21_RS09405	COG2814	Major facilitator Superfamily
J5P21_RS09430	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS09435	COG0583	DNA-binding transcription factor activity
J5P21_RS09440	COG1414	Transcriptional regulator
J5P21_RS09455	COG2391	methyltransferase activity
J5P21_RS09465	COG4993	Dehydrogenase
J5P21_RS09470	COG3659	wide pore channel activity
J5P21_RS09475	COG3420	alginic acid biosynthetic process
J5P21_RS09480	COG0710	3-dehydroquinate dehydratase activity
J5P21_RS09485	COG3485	protocatechuate 3,4-dioxygenase
J5P21_RS09490	COG3485	protocatechuate 3,4-dioxygenase
J5P21_RS09495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
J5P21_RS09500	COG2271	Major facilitator Superfamily
J5P21_RS09505	COG0596	Alpha beta hydrolase
J5P21_RS09510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J5P21_RS09515	COG0183	Belongs to the thiolase family
J5P21_RS09520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
J5P21_RS09525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
J5P21_RS09535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
J5P21_RS09540	COG2323	membrane
J5P21_RS09585	COG0446	pyridine nucleotide-disulphide oxidoreductase
J5P21_RS09585	COG1902	pentaerythritol trinitrate reductase activity
J5P21_RS09610	COG0542	response to heat
J5P21_RS09615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
J5P21_RS09645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5P21_RS09650	COG0569	domain protein
J5P21_RS09655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J5P21_RS09670	COG4774	siderophore transport
J5P21_RS09675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J5P21_RS09685	COG1585	Membrane protein implicated in regulation of membrane protease activity
J5P21_RS09700	COG1294	oxidase, subunit
J5P21_RS09705	COG4890	Cyd operon protein YbgT
J5P21_RS09720	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
J5P21_RS09730	COG0552	protein localization to endoplasmic reticulum
J5P21_RS09755	COG0517	IMP dehydrogenase activity
J5P21_RS09755	COG0516	GMP reductase activity
J5P21_RS09760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5P21_RS09765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
J5P21_RS09775	COG0583	DNA-binding transcription factor activity
J5P21_RS09780	COG0024	Methionine aminopeptidase
J5P21_RS09810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J5P21_RS09810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J5P21_RS09815	COG1105	Belongs to the carbohydrate kinase PfkB family
J5P21_RS09820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5P21_RS09820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J5P21_RS09820	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
J5P21_RS09840	COG5001	Diguanylate cyclase
J5P21_RS09840	COG3300	MHYT domain
J5P21_RS09855	COG2135	peptidase activity
J5P21_RS09860	COG0659	secondary active sulfate transmembrane transporter activity
J5P21_RS09875	COG1113	amino acid transport
J5P21_RS09885	COG1522	sequence-specific DNA binding
J5P21_RS09910	COG1011	Hydrolase
J5P21_RS09915	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J5P21_RS09925	COG2137	regulation of response to DNA damage stimulus
J5P21_RS09940	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
J5P21_RS09975	COG0575	Belongs to the CDS family
J5P21_RS09980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J5P21_RS10005	COG3852	Histidine kinase
J5P21_RS10010	COG2204	response regulator
J5P21_RS10065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5P21_RS10070	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
J5P21_RS10090	COG0697	spore germination
J5P21_RS10095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5P21_RS10110	COG0521	Mo-molybdopterin cofactor biosynthetic process
J5P21_RS10110	COG0315	cyclic pyranopterin monophosphate synthase activity
J5P21_RS10125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J5P21_RS10130	COG0243	molybdopterin cofactor binding
J5P21_RS10140	COG0243	molybdopterin cofactor binding
J5P21_RS10145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5P21_RS10150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5P21_RS10150	COG2146	nitrite reductase [NAD(P)H] activity
J5P21_RS10160	COG0745	RESPONSE REGULATOR receiver
J5P21_RS10165	COG1116	anion transmembrane transporter activity
J5P21_RS10165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5P21_RS10185	COG0511	ligase activity, forming carbon-carbon bonds
J5P21_RS10200	COG2814	Major facilitator Superfamily
J5P21_RS10235	COG3293	Transposase
J5P21_RS10240	COG1063	alcohol dehydrogenase
J5P21_RS10250	COG3179	chitinase
J5P21_RS10290	COG0739	heme binding
J5P21_RS10290	COG0741	lytic transglycosylase activity
J5P21_RS10290	COG1196	nuclear chromosome segregation
J5P21_RS10300	COG1598	PFAM Uncharacterised protein family UPF0150
J5P21_RS10490	COG3620	sequence-specific DNA binding
J5P21_RS10575	COG0069	glutamate synthase activity
J5P21_RS10605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
J5P21_RS10615	COG1454	alcohol dehydrogenase
J5P21_RS10620	COG0824	Thioesterase
J5P21_RS10630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J5P21_RS10645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J5P21_RS10650	COG2030	dehydratase
J5P21_RS10660	COG0183	Belongs to the thiolase family
J5P21_RS10670	COG0583	DNA-binding transcription factor activity
J5P21_RS10675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J5P21_RS10685	COG1522	sequence-specific DNA binding
J5P21_RS10690	COG3135	benzoate transporter
J5P21_RS10700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J5P21_RS10725	COG0589	response to stress
J5P21_RS10730	COG0488	(ABC) transporter
J5P21_RS10750	COG4773	Receptor
J5P21_RS10780	COG0668	transmembrane transport
J5P21_RS10790	COG1309	transcriptional regulator
J5P21_RS10805	COG1605	Chorismate mutase
J5P21_RS10815	COG4221	oxidoreductase activity
J5P21_RS10845	COG0308	aminopeptidase N
J5P21_RS10870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J5P21_RS10875	COG1454	alcohol dehydrogenase
J5P21_RS10895	COG0531	amino acid
J5P21_RS10900	COG4303	Ethanolamine ammonia lyase large subunit
J5P21_RS10905	COG4302	ethanolamine ammonia-lyase activity
J5P21_RS10910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5P21_RS10910	COG0519	Catalyzes the synthesis of GMP from XMP
J5P21_RS10915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J5P21_RS10940	COG0697	spore germination
J5P21_RS10945	COG1923	regulation of RNA biosynthetic process
J5P21_RS10955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J5P21_RS10960	COG0802	atpase or kinase
J5P21_RS10980	COG1187	pseudouridine synthase activity
J5P21_RS10995	COG0583	DNA-binding transcription factor activity
J5P21_RS11010	COG2814	Major facilitator Superfamily
J5P21_RS11015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J5P21_RS11040	COG0729	surface antigen
J5P21_RS11060	COG0174	glutamine synthetase
J5P21_RS11065	COG0745	RESPONSE REGULATOR receiver
J5P21_RS11070	COG2205	protein histidine kinase activity
J5P21_RS11080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
J5P21_RS11085	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
J5P21_RS11110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS11115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5P21_RS11120	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS11135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5P21_RS11140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5P21_RS11160	COG0583	DNA-binding transcription factor activity
J5P21_RS11175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5P21_RS11185	COG3658	cytochrome
J5P21_RS11190	COG1215	transferase activity, transferring glycosyl groups
J5P21_RS11195	COG1649	PFAM Uncharacterised BCR, COG1649
J5P21_RS11195	COG0726	polysaccharide deacetylase
J5P21_RS11220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
J5P21_RS11225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
J5P21_RS11235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
J5P21_RS11260	COG0305	Participates in initiation and elongation during chromosome replication
J5P21_RS11265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J5P21_RS11275	COG1305	Transglutaminase-like
J5P21_RS11285	COG2308	Evidence 4 Homologs of previously reported genes of
J5P21_RS11315	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
J5P21_RS11320	COG0138	bifunctional purine biosynthesis protein purh
J5P21_RS11325	COG0151	Belongs to the GarS family
J5P21_RS11330	COG1464	Belongs to the NlpA lipoprotein family
J5P21_RS11335	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J5P21_RS11340	COG2011	ABC-type metal ion transport system permease component
J5P21_RS11345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J5P21_RS11355	COG1301	dicarboxylic acid transport
J5P21_RS11385	COG1794	racemase activity, acting on amino acids and derivatives
J5P21_RS11405	COG0745	RESPONSE REGULATOR receiver
J5P21_RS11410	COG0642	Histidine kinase
J5P21_RS11415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J5P21_RS11425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
J5P21_RS11465	COG2351	hydroxyisourate hydrolase activity
J5P21_RS11475	COG3008	intermembrane lipid transfer
J5P21_RS11475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
J5P21_RS11480	COG2995	paraquat-inducible protein a
J5P21_RS11495	COG2985	domain, Protein
J5P21_RS11520	COG0477	Major facilitator Superfamily
J5P21_RS11570	COG2186	Transcriptional regulator
J5P21_RS11580	COG0786	glutamate:sodium symporter activity
J5P21_RS11585	COG3243	poly(R)-hydroxyalkanoic acid synthase
J5P21_RS11610	COG3111	PFAM Bacterial OB fold (BOF) protein
J5P21_RS11725	COG2831	hemolysin activation secretion protein
J5P21_RS11780	COG1610	YqeY-like protein
J5P21_RS11785	COG4783	chaperone-mediated protein folding
J5P21_RS11810	COG1286	toxin biosynthetic process
J5P21_RS11840	COG0778	Nitroreductase
J5P21_RS11850	COG0513	Belongs to the DEAD box helicase family
J5P21_RS11870	COG2363	Small membrane protein
J5P21_RS11900	COG1234	tRNA 3'-trailer cleavage
J5P21_RS11905	COG2195	Cleaves the N-terminal amino acid of tripeptides
J5P21_RS11915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J5P21_RS11925	COG2819	hydrolase of the alpha beta superfamily
J5P21_RS11930	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS11935	COG1301	dicarboxylic acid transport
J5P21_RS11940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J5P21_RS11945	COG3139	Protein of unknown function (DUF1315)
J5P21_RS11950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J5P21_RS11955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J5P21_RS11965	COG0494	nUDIX hydrolase
J5P21_RS11975	COG0642	Histidine kinase
J5P21_RS11990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J5P21_RS12000	COG1720	tRNA m6t6A37 methyltransferase activity
J5P21_RS12015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5P21_RS12020	COG0826	peptidase U32
J5P21_RS12025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J5P21_RS12035	COG4598	ABC transporter
J5P21_RS12040	COG4160	amino acid transport
J5P21_RS12045	COG4215	(ABC) transporter
J5P21_RS12060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS12100	COG1131	(ABC) transporter
J5P21_RS12105	COG0842	Transport permease protein
J5P21_RS12120	COG0772	Belongs to the SEDS family
J5P21_RS12125	COG2951	lytic endotransglycosylase activity
J5P21_RS12150	COG2207	Transcriptional regulator
J5P21_RS12165	COG0052	Belongs to the universal ribosomal protein uS2 family
J5P21_RS12170	COG0024	Methionine aminopeptidase
J5P21_RS12180	COG2223	nitrite transmembrane transporter activity
J5P21_RS12190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5P21_RS12195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
J5P21_RS12200	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS12215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
J5P21_RS12220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J5P21_RS12225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5P21_RS12245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5P21_RS12250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J5P21_RS12255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J5P21_RS12290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
J5P21_RS12300	COG0174	glutamine synthetase
J5P21_RS12315	COG0512	Glutamine amidotransferase of anthranilate synthase
J5P21_RS12320	COG0308	aminopeptidase N
J5P21_RS12350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J5P21_RS12360	COG0302	gtp cyclohydrolase
J5P21_RS12380	COG3739	integral membrane protein
J5P21_RS12395	COG1169	isochorismate synthase
J5P21_RS12405	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
J5P21_RS12410	COG1132	(ABC) transporter
J5P21_RS12415	COG1132	(ABC) transporter
J5P21_RS12430	COG1535	isochorismatase
J5P21_RS12430	COG3433	isochorismatase activity
J5P21_RS12435	COG1021	2,3-dihydroxybenzoate-AMP ligase
J5P21_RS12440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5P21_RS12450	COG4774	siderophore transport
J5P21_RS12455	COG4607	ABC-type enterochelin transport system periplasmic component
J5P21_RS12460	COG4604	ABC transporter, ATP-binding protein
J5P21_RS12465	COG4605	iron ion homeostasis
J5P21_RS12470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J5P21_RS12475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5P21_RS12490	COG2964	Protein conserved in bacteria
J5P21_RS12500	COG1741	Belongs to the pirin family
J5P21_RS12530	COG2130	NADP-dependent
J5P21_RS12540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J5P21_RS12550	COG0596	Alpha beta hydrolase
J5P21_RS12565	COG0583	DNA-binding transcription factor activity
J5P21_RS12570	COG1335	isochorismatase
J5P21_RS12610	COG2879	small protein
J5P21_RS12615	COG1966	Carbon starvation protein
J5P21_RS12635	COG4943	cyclic-guanylate-specific phosphodiesterase activity
J5P21_RS12660	COG1067	ATP-dependent peptidase activity
J5P21_RS12665	COG0583	DNA-binding transcription factor activity
J5P21_RS12690	COG1686	Belongs to the peptidase S11 family
J5P21_RS12695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
J5P21_RS12730	COG0616	signal peptide processing
J5P21_RS12735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J5P21_RS12745	COG0573	inorganic phosphate transmembrane transporter activity
J5P21_RS12750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J5P21_RS12755	COG1113	amino acid transport
J5P21_RS12760	COG3961	Belongs to the TPP enzyme family
J5P21_RS12765	COG1522	sequence-specific DNA binding
J5P21_RS12775	COG0076	glutamate decarboxylase activity
J5P21_RS12780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5P21_RS12795	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5P21_RS12805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5P21_RS12840	COG0352	thiamine-phosphate diphosphorylase activity
J5P21_RS12865	COG0612	Peptidase, M16
J5P21_RS12875	COG1823	symporter activity
J5P21_RS12880	COG0583	DNA-binding transcription factor activity
J5P21_RS12885	COG0477	Major facilitator Superfamily
J5P21_RS12910	COG0582	viral genome integration into host DNA
J5P21_RS13010	COG3328	transposase activity
J5P21_RS13190	COG3646	Phage regulatory protein
J5P21_RS13190	COG3645	SOS response
J5P21_RS13260	COG1187	pseudouridine synthase activity
J5P21_RS13275	COG1686	Belongs to the peptidase S11 family
J5P21_RS13280	COG1252	NADH dehydrogenase
J5P21_RS13290	COG0415	Belongs to the DNA photolyase family
J5P21_RS13305	COG1215	transferase activity, transferring glycosyl groups
J5P21_RS13335	COG2070	2-Nitropropane dioxygenase
J5P21_RS13390	COG0556	nucleotide-excision repair
J5P21_RS13410	COG0436	Aminotransferase
J5P21_RS13420	COG0443	Heat shock 70 kDa protein
J5P21_RS13450	COG4221	oxidoreductase activity
J5P21_RS13460	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
J5P21_RS13465	COG1381	Involved in DNA repair and RecF pathway recombination
J5P21_RS13475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J5P21_RS13490	COG0681	Belongs to the peptidase S26 family
J5P21_RS13500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J5P21_RS13510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J5P21_RS13530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J5P21_RS13535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J5P21_RS13540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
J5P21_RS13550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
J5P21_RS13555	COG4208	sulfate ABC transporter
J5P21_RS13560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J5P21_RS13565	COG0583	DNA-binding transcription factor activity
J5P21_RS13570	COG4625	pathogenesis
J5P21_RS13585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J5P21_RS13600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
J5P21_RS13610	COG1051	belongs to the nudix hydrolase family
J5P21_RS13610	COG1056	cytidyltransferase-related domain
J5P21_RS13615	COG1024	Enoyl-CoA hydratase
J5P21_RS13625	COG2814	Major facilitator Superfamily
J5P21_RS13630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J5P21_RS13630	COG0047	phosphoribosylformylglycinamidine synthase activity
J5P21_RS13650	COG1473	amidohydrolase
J5P21_RS13655	COG0824	Thioesterase
J5P21_RS13675	COG0823	Involved in the tonB-independent uptake of proteins
J5P21_RS13695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J5P21_RS13730	COG0628	permease
J5P21_RS13740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J5P21_RS13745	COG0596	Alpha beta hydrolase
J5P21_RS13750	COG0616	signal peptide processing
J5P21_RS13750	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J5P21_RS13760	COG0658	competence protein
J5P21_RS13760	COG2333	competence protein COMEC
J5P21_RS13765	COG1136	(ABC) transporter
J5P21_RS13770	COG4591	ABC-type transport system involved in lipoprotein release permease component
J5P21_RS13805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS13825	COG0463	Glycosyl transferase, family 2
J5P21_RS13855	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J5P21_RS13860	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS13870	COG0019	diaminopimelate decarboxylase activity
J5P21_RS13880	COG1113	amino acid transport
J5P21_RS13895	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
J5P21_RS13905	COG3339	Conserved Protein
J5P21_RS13910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
J5P21_RS13915	COG0243	molybdopterin cofactor binding
J5P21_RS13920	COG1929	Belongs to the glycerate kinase type-1 family
J5P21_RS13935	COG0778	Nitroreductase
J5P21_RS13955	COG3811	Belongs to the UPF0386 family
J5P21_RS13965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5P21_RS13980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J5P21_RS14000	COG0741	lytic transglycosylase activity
J5P21_RS14020	COG0584	glycerophosphoryl diester phosphodiesterase
J5P21_RS14050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
J5P21_RS14055	COG1597	lipid kinase activity
J5P21_RS14070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J5P21_RS14075	COG0477	Major facilitator Superfamily
J5P21_RS14125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J5P21_RS14130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J5P21_RS14155	COG0505	Belongs to the CarA family
J5P21_RS14170	COG1309	transcriptional regulator
J5P21_RS14175	COG0251	oxidation-reduction process
J5P21_RS14185	COG0589	response to stress
J5P21_RS14200	COG2843	Capsule synthesis protein
J5P21_RS14220	COG2321	neutral zinc metallopeptidase
J5P21_RS14225	COG2354	Protein conserved in bacteria
J5P21_RS14245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J5P21_RS14270	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
J5P21_RS14275	COG1053	succinate dehydrogenase
J5P21_RS14280	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
J5P21_RS14285	COG2009	succinate dehydrogenase
J5P21_RS14320	COG2921	Belongs to the UPF0250 family
J5P21_RS14325	COG0321	lipoyl(octanoyl) transferase activity
J5P21_RS14340	COG0531	amino acid
J5P21_RS14350	COG1733	regulation of RNA biosynthetic process
J5P21_RS14355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
J5P21_RS14360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
J5P21_RS14360	COG1648	precorrin-2 dehydrogenase activity
J5P21_RS14375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
J5P21_RS14405	COG0671	phosphoesterase, PA-phosphatase related
J5P21_RS14410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS14420	COG1538	Outer membrane efflux protein
J5P21_RS14425	COG0393	Putative heavy-metal-binding
J5P21_RS14430	COG0393	Putative heavy-metal-binding
J5P21_RS14440	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS14450	COG0525	valine-tRNA ligase activity
J5P21_RS14470	COG0583	DNA-binding transcription factor activity
J5P21_RS14475	COG0004	ammonium transporteR
J5P21_RS14485	COG0642	Histidine kinase
J5P21_RS14490	COG0745	RESPONSE REGULATOR receiver
J5P21_RS14495	COG2194	sulfuric ester hydrolase activity
J5P21_RS14515	COG1752	Esterase of the alpha-beta hydrolase superfamily
J5P21_RS14530	COG2315	Protein conserved in bacteria
J5P21_RS14535	COG0142	geranyltranstransferase activity
J5P21_RS14540	COG2828	Protein conserved in bacteria
J5P21_RS14545	COG1113	amino acid transport
J5P21_RS14565	COG2207	Transcriptional regulator
J5P21_RS14590	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5P21_RS14600	COG0560	Phosphoserine phosphatase
J5P21_RS14610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J5P21_RS14620	COG1530	ribonuclease E activity
J5P21_RS14625	COG0424	maF-like protein
J5P21_RS14630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
J5P21_RS14635	COG1792	Involved in formation and maintenance of cell shape
J5P21_RS14640	COG1077	Cell shape determining protein MreB Mrl
J5P21_RS14645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5P21_RS14655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J5P21_RS14680	COG3590	peptidase
J5P21_RS14685	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
J5P21_RS14690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J5P21_RS14695	COG1752	Esterase of the alpha-beta hydrolase superfamily
J5P21_RS14700	COG1115	amino acid carrier protein
J5P21_RS14720	COG2814	Major facilitator Superfamily
J5P21_RS14725	COG1289	transmembrane transporter activity
J5P21_RS14735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
J5P21_RS14775	COG1376	ErfK ybiS ycfS ynhG family protein
J5P21_RS14780	COG2832	Protein of unknown function (DUF454)
J5P21_RS14790	COG5510	response to toxic substance
J5P21_RS14810	COG0840	transmembrane signaling receptor activity
J5P21_RS14850	COG3422	double-strand break repair
J5P21_RS14855	COG2824	Alkylphosphonate utilization operon protein PhnA
J5P21_RS14860	COG3189	MarR family transcriptional regulator
J5P21_RS14870	COG0354	folic acid binding
J5P21_RS14875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5P21_RS14885	COG0679	Auxin Efflux Carrier
J5P21_RS14890	COG1902	pentaerythritol trinitrate reductase activity
J5P21_RS14895	COG4772	TonB-dependent receptor
J5P21_RS14900	COG2094	Belongs to the DNA glycosylase MPG family
J5P21_RS14925	COG1217	gtp-binding protein TYPA
J5P21_RS14930	COG2233	PERMEase
J5P21_RS14940	COG0833	amino acid
J5P21_RS14945	COG1690	Belongs to the RtcB family
J5P21_RS14955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
J5P21_RS14955	COG2885	chlorophyll binding
J5P21_RS14965	COG0183	Belongs to the thiolase family
J5P21_RS14985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
J5P21_RS15005	COG2207	Transcriptional regulator
J5P21_RS15010	COG0183	Belongs to the thiolase family
J5P21_RS15030	COG2153	protein acetylation
J5P21_RS15050	COG1272	protein, Hemolysin III
J5P21_RS15055	COG0477	Major facilitator Superfamily
J5P21_RS15070	COG0450	alkyl hydroperoxide reductase
J5P21_RS15090	COG0285	dihydrofolate synthase activity
J5P21_RS15140	COG2096	Adenosyltransferase
J5P21_RS15160	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
J5P21_RS15165	COG0745	RESPONSE REGULATOR receiver
J5P21_RS15170	COG2205	protein histidine kinase activity
J5P21_RS15180	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS15185	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS15250	COG0438	transferase activity, transferring glycosyl groups
J5P21_RS15255	COG0463	Glycosyl transferase, family 2
J5P21_RS15260	COG0726	polysaccharide deacetylase
J5P21_RS15280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
J5P21_RS15285	COG2205	protein histidine kinase activity
J5P21_RS15295	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J5P21_RS15305	COG4695	Portal protein
J5P21_RS15435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5P21_RS15535	COG1862	Preprotein translocase
J5P21_RS15545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J5P21_RS15550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J5P21_RS15560	COG3781	membrane
J5P21_RS15565	COG0613	PHP domain protein
J5P21_RS15575	COG2350	Protein conserved in bacteria
J5P21_RS15605	COG1607	acyl-coa hydrolase
J5P21_RS15665	COG2199	diguanylate cyclase activity
J5P21_RS15675	COG1408	metallophosphoesterase
J5P21_RS15680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J5P21_RS15690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J5P21_RS15710	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J5P21_RS15715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J5P21_RS15730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J5P21_RS15740	COG2969	positive regulation of protein catabolic process
J5P21_RS15780	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS15785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
J5P21_RS15800	COG1309	transcriptional regulator
J5P21_RS15805	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS15850	COG1183	phosphatidylcholine synthase activity
J5P21_RS15855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
J5P21_RS15885	COG0739	heme binding
J5P21_RS15885	COG0741	lytic transglycosylase activity
J5P21_RS15885	COG1196	nuclear chromosome segregation
J5P21_RS15895	COG1702	phosphate starvation-inducible protein PhoH
J5P21_RS15930	COG1295	ribonuclease BN
J5P21_RS15935	COG0697	spore germination
J5P21_RS15940	COG2169	Transcriptional regulator
J5P21_RS15945	COG0179	Fumarylacetoacetate (FAA) hydrolase
J5P21_RS15995	COG0557	exoribonuclease II activity
J5P21_RS16000	COG0339	signal peptide processing
J5P21_RS16005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
J5P21_RS16035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
J5P21_RS16040	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS16195	COG0626	cystathionine gamma-synthase activity
J5P21_RS16200	COG0433	COG0433 Predicted ATPase
J5P21_RS16210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
J5P21_RS16210	COG1017	nitric oxide dioxygenase activity
J5P21_RS16215	COG1959	2 iron, 2 sulfur cluster binding
J5P21_RS16230	COG1301	dicarboxylic acid transport
J5P21_RS16235	COG1946	Acyl-CoA thioesterase
J5P21_RS16255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J5P21_RS16260	COG1040	competence protein
J5P21_RS16265	COG0494	nUDIX hydrolase
J5P21_RS16275	COG0598	Magnesium transport protein CorA
J5P21_RS16285	COG2854	intermembrane phospholipid transfer
J5P21_RS16295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
J5P21_RS16300	COG1127	ABC transporter
J5P21_RS16310	COG0513	Belongs to the DEAD box helicase family
J5P21_RS16330	COG0408	coproporphyrinogen oxidase activity
J5P21_RS16350	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS16360	COG1983	PspC domain protein
J5P21_RS16365	COG0517	IMP dehydrogenase activity
J5P21_RS16415	COG0583	DNA-binding transcription factor activity
J5P21_RS16455	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS16465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J5P21_RS16470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J5P21_RS16475	COG0833	amino acid
J5P21_RS16505	COG1192	Involved in chromosome partitioning
J5P21_RS16510	COG0628	permease
J5P21_RS16520	COG1289	transmembrane transporter activity
J5P21_RS16535	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5P21_RS16540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
J5P21_RS16550	COG0277	FAD linked oxidase domain protein
J5P21_RS16555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J5P21_RS16580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J5P21_RS16585	COG5380	lipid catabolic process
J5P21_RS16605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J5P21_RS16655	COG0194	GDP metabolic process
J5P21_RS16670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J5P21_RS16690	COG3307	-O-antigen
J5P21_RS16705	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
J5P21_RS16710	COG1704	LemA family
J5P21_RS16720	COG0493	'glutamate synthase
J5P21_RS16725	COG0069	glutamate synthase activity
J5P21_RS16725	COG0067	glutamate synthase
J5P21_RS16725	COG0070	glutamate synthase
J5P21_RS16775	COG2226	methyltransferase
J5P21_RS16790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J5P21_RS16795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J5P21_RS16840	COG0833	amino acid
J5P21_RS16925	COG0488	(ABC) transporter
J5P21_RS16930	COG2873	o-acetylhomoserine
J5P21_RS16935	COG4221	oxidoreductase activity
J5P21_RS16940	COG0659	secondary active sulfate transmembrane transporter activity
J5P21_RS16965	COG0427	acetyl-CoA hydrolase
J5P21_RS16995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J5P21_RS17025	COG2329	Antibiotic biosynthesis monooxygenase
J5P21_RS17040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
J5P21_RS17110	COG2249	NAD(P)H dehydrogenase (quinone) activity
J5P21_RS17115	COG1733	regulation of RNA biosynthetic process
J5P21_RS17150	COG0667	Aldo Keto reductase
J5P21_RS17170	COG0583	DNA-binding transcription factor activity
J5P21_RS17175	COG2814	Major facilitator Superfamily
J5P21_RS17205	COG1335	isochorismatase
J5P21_RS17215	COG1012	belongs to the aldehyde dehydrogenase family
J5P21_RS17220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
J5P21_RS17230	COG1113	amino acid transport
J5P21_RS17240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
J5P21_RS17255	COG2814	Major facilitator Superfamily
J5P21_RS17265	COG0351	phosphomethylpyrimidine kinase
J5P21_RS17265	COG0352	thiamine-phosphate diphosphorylase activity
J5P21_RS17265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
J5P21_RS17285	COG1309	transcriptional regulator
J5P21_RS17290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J5P21_RS17310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
J5P21_RS17320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J5P21_RS17325	COG3162	membrane
J5P21_RS17330	COG0784	Response regulator, receiver
J5P21_RS17330	COG2198	Histidine kinase
J5P21_RS17330	COG2205	protein histidine kinase activity
J5P21_RS17355	COG1522	sequence-specific DNA binding
J5P21_RS17360	COG1335	isochorismatase
J5P21_RS17365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5P21_RS17375	COG0668	transmembrane transport
J5P21_RS17380	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J5P21_RS17385	COG1519	Transferase
J5P21_RS17390	COG1902	pentaerythritol trinitrate reductase activity
J5P21_RS17410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J5P21_RS17435	COG0426	domain, Protein
J5P21_RS17435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
J5P21_RS17440	COG4774	siderophore transport
J5P21_RS17445	COG2119	membrane
J5P21_RS17455	COG0508	dehydrogenase complex catalyzes the overall conversion of
J5P21_RS17465	COG4942	peptidase
J5P21_RS17480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J5P21_RS17490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J5P21_RS17510	COG0189	ligase activity
J5P21_RS17530	COG0708	Exodeoxyribonuclease III
J5P21_RS17535	COG1393	Belongs to the ArsC family
J5P21_RS17550	COG3706	GGDEF domain
J5P21_RS17585	COG2351	hydroxyisourate hydrolase activity
J5P21_RS17590	COG2233	PERMEase
J5P21_RS17600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
J5P21_RS17610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
J5P21_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS17625	COG3150	esterase
J5P21_RS17645	COG2826	transposase and inactivated derivatives, IS30 family
J5P21_RS17665	COG0673	inositol 2-dehydrogenase activity
J5P21_RS17670	COG1324	tolerance protein
J5P21_RS17695	COG2826	transposase and inactivated derivatives, IS30 family
J5P21_RS17720	COG2918	glutathione biosynthetic process
J5P21_RS17735	COG2733	membrane
J5P21_RS17740	COG0436	Aminotransferase
J5P21_RS17745	COG0534	Mate efflux family protein
J5P21_RS17805	COG0753	catalase activity
J5P21_RS17850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
J5P21_RS17855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
J5P21_RS17865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J5P21_RS17870	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J5P21_RS17885	COG0010	Belongs to the arginase family
J5P21_RS17915	COG2188	Transcriptional regulator
J5P21_RS17925	COG0523	cobalamin synthesis protein
J5P21_RS17935	COG1113	amino acid transport
J5P21_RS17945	COG0625	glutathione transferase activity
J5P21_RS17965	COG1683	Conserved Protein
J5P21_RS17970	COG0534	Mate efflux family protein
J5P21_RS17975	COG0385	Bile acid
J5P21_RS17980	COG1335	isochorismatase
J5P21_RS17985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J5P21_RS18010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J5P21_RS18015	COG2133	pyrroloquinoline quinone binding
J5P21_RS18020	COG2983	Belongs to the UPF0260 family
J5P21_RS18030	COG0400	carboxylic ester hydrolase activity
J5P21_RS18040	COG1194	a g-specific adenine glycosylase
J5P21_RS18055	COG2818	Glycosylase
J5P21_RS18060	COG1064	alcohol dehydrogenase
J5P21_RS18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J5P21_RS18080	COG0583	DNA-binding transcription factor activity
J5P21_RS18085	COG0656	L-ascorbic acid biosynthetic process
J5P21_RS18090	COG2814	Major facilitator Superfamily
J5P21_RS18125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
J5P21_RS18140	COG2233	PERMEase
J5P21_RS18145	COG0583	DNA-binding transcription factor activity
J5P21_RS18170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J5P21_RS18180	COG0733	neurotransmitter:sodium symporter activity
J5P21_RS18220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J5P21_RS18225	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
J5P21_RS18230	COG0596	Alpha beta hydrolase
J5P21_RS18255	COG0488	(ABC) transporter
J5P21_RS18260	COG0586	Pfam SNARE associated Golgi protein
J5P21_RS18270	COG0187	DNA topoisomerase II activity
J5P21_RS18280	COG0592	DNA-directed DNA polymerase activity
J5P21_RS18310	COG0706	membrane insertase activity
J5P21_RS18325	COG1230	cation diffusion facilitator family transporter
J5P21_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5P21_RS18345	COG0402	S-adenosylhomocysteine deaminase activity
J5P21_RS18355	COG0754	glutathionylspermidine amidase activity
J5P21_RS18365	COG0861	Integral membrane protein TerC family
J5P21_RS18370	COG0671	phosphoesterase, PA-phosphatase related
J5P21_RS18380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J5P21_RS18395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
J5P21_RS18400	COG2951	lytic endotransglycosylase activity
J5P21_RS18450	COG0657	acetylesterase activity
J5P21_RS18455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J5P21_RS18495	COG1047	Peptidyl-prolyl cis-trans
J5P21_RS18505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J5P21_RS18510	COG0196	riboflavin kinase activity
J5P21_RS18520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J5P21_RS18525	COG1309	transcriptional regulator
J5P21_RS18530	COG1116	anion transmembrane transporter activity
J5P21_RS18535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J5P21_RS18540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
J5P21_RS18545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5P21_RS18550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J5P21_RS18570	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS18575	COG0546	phosphoglycolate phosphatase activity
J5P21_RS18635	COG3023	N-Acetylmuramoyl-L-alanine amidase
J5P21_RS18640	COG0728	peptidoglycan biosynthetic process
J5P21_RS18670	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
J5P21_RS18680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
J5P21_RS18685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J5P21_RS18690	COG2089	acid synthase
J5P21_RS18700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
J5P21_RS18705	COG1083	cytidylyl-transferase
J5P21_RS18710	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS18720	COG1028	Short-chain dehydrogenase reductase Sdr
J5P21_RS18755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J5P21_RS18770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J5P21_RS18785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J5P21_RS18800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J5P21_RS18805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J5P21_RS18815	COG2186	Transcriptional regulator
J5P21_RS18825	COG0277	FAD linked oxidase domain protein
J5P21_RS18830	COG1448	Aminotransferase
J5P21_RS18840	COG1802	Transcriptional regulator
J5P21_RS18855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J5P21_RS18885	COG3328	transposase activity
J5P21_RS18900	COG0564	pseudouridine synthase activity
J5P21_RS18940	COG0251	oxidation-reduction process
J5P21_RS18945	COG1113	amino acid transport
J5P21_RS18950	COG1113	amino acid transport
J5P21_RS18970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
J5P21_RS18975	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS18980	COG1024	Enoyl-CoA hydratase
J5P21_RS18985	COG1024	Enoyl-CoA hydratase
J5P21_RS18990	COG0477	Major facilitator Superfamily
J5P21_RS18995	COG3916	Acyl-homoserine-lactone synthase
J5P21_RS19005	COG2197	response regulator
J5P21_RS19015	COG1960	acyl-CoA dehydrogenase activity
J5P21_RS19020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J5P21_RS19020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
J5P21_RS19020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
J5P21_RS19020	COG3321	synthase
J5P21_RS19040	COG2267	carboxylic ester hydrolase activity
J5P21_RS19060	COG0271	Belongs to the BolA IbaG family
J5P21_RS19070	COG1192	Involved in chromosome partitioning
J5P21_RS19085	COG0586	Pfam SNARE associated Golgi protein
J5P21_RS19090	COG2259	Doxx family
J5P21_RS19095	COG4399	Belongs to the UPF0754 family
J5P21_RS19100	COG0519	Catalyzes the synthesis of GMP from XMP
J5P21_RS19100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J5P21_RS19145	COG0281	malic enzyme
J5P21_RS19150	COG2837	iron assimilation
J5P21_RS19155	COG1280	lysine exporter protein (LysE YggA)
J5P21_RS19160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J5P21_RS19165	COG1121	(ABC) transporter
J5P21_RS19230	COG0386	Belongs to the glutathione peroxidase family
J5P21_RS19245	COG1309	transcriptional regulator
J5P21_RS19250	COG0697	spore germination
J5P21_RS19260	COG0758	DNA mediated transformation
J5P21_RS19315	COG3173	Aminoglycoside phosphotransferase
J5P21_RS19320	COG0488	(ABC) transporter
J5P21_RS19335	COG0482	sulfurtransferase activity
J5P21_RS19480	COG1192	Involved in chromosome partitioning
J5P21_RS19510	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J5P21_RS19515	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
J5P21_RS19555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J5P21_RS19695	COG0583	DNA-binding transcription factor activity
J5P21_RS19720	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
J5P21_RS19730	COG0659	secondary active sulfate transmembrane transporter activity
J5P21_RS19785	COG1373	ATPase (AAA superfamily
J5P21_RS19825	COG1309	transcriptional regulator
J5P21_RS19850	COG0633	Ferredoxin
J5P21_RS19855	COG2207	Transcriptional regulator
J5P21_RS20010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J5P21_RS20060	COG1192	Involved in chromosome partitioning
J5P21_RS20070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5P21_RS20110	COG0739	heme binding
J5P21_RS20345	COG0501	Belongs to the peptidase M48B family
J5P21_RS20380	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
J5P21_RS20450	COG1525	nuclease
J5P21_RS20510	COG1475	DNA binding
J5P21_RS20525	COG3853	Toxic anion resistance protein (TelA)
J5P21_RS20610	COG0484	heat shock protein binding
J5P21_RS20665	COG0589	response to stress
J5P21_RS20670	COG0659	secondary active sulfate transmembrane transporter activity
J5P21_RS20755	COG2826	transposase and inactivated derivatives, IS30 family
J5P21_RS20765	COG2826	transposase and inactivated derivatives, IS30 family
J5P21_RS20790	COG0741	lytic transglycosylase activity
J5P21_RS20825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
J5P21_RS20910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J5P21_RS20945	COG4683	PFAM Phage derived protein Gp49-like (DUF891)