locus-tag	class	description
LO004_RS00020	COG0706	membrane insertase activity
LO004_RS00035	COG1230	cation diffusion facilitator family transporter
LO004_RS00040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LO004_RS00055	COG0402	S-adenosylhomocysteine deaminase activity
LO004_RS00065	COG0754	glutathionylspermidine amidase activity
LO004_RS00075	COG0861	Integral membrane protein TerC family
LO004_RS00080	COG0671	phosphoesterase, PA-phosphatase related
LO004_RS00090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LO004_RS00105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LO004_RS00110	COG2951	lytic endotransglycosylase activity
LO004_RS00140	COG0583	DNA-binding transcription factor activity
LO004_RS00160	COG0657	acetylesterase activity
LO004_RS00165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LO004_RS00205	COG1047	Peptidyl-prolyl cis-trans
LO004_RS00215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LO004_RS00220	COG0196	riboflavin kinase activity
LO004_RS00230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LO004_RS00235	COG1309	transcriptional regulator
LO004_RS00240	COG1116	anion transmembrane transporter activity
LO004_RS00245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LO004_RS00250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LO004_RS00255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LO004_RS00260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LO004_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS00285	COG0546	phosphoglycolate phosphatase activity
LO004_RS00345	COG3023	N-Acetylmuramoyl-L-alanine amidase
LO004_RS00350	COG0728	peptidoglycan biosynthetic process
LO004_RS00375	COG1596	polysaccharide export
LO004_RS00380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LO004_RS00385	COG1086	Polysaccharide biosynthesis protein
LO004_RS00390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LO004_RS00395	COG1083	cytidylyl-transferase
LO004_RS00410	COG2089	acid synthase
LO004_RS00440	COG1216	Glycosyl transferase, family 2
LO004_RS00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LO004_RS00450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LO004_RS00465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LO004_RS00480	COG3293	Transposase
LO004_RS00490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LO004_RS00500	COG2186	Transcriptional regulator
LO004_RS00510	COG0277	FAD linked oxidase domain protein
LO004_RS00515	COG1448	Aminotransferase
LO004_RS00525	COG1802	Transcriptional regulator
LO004_RS00540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LO004_RS00560	COG1051	belongs to the nudix hydrolase family
LO004_RS00595	COG0564	pseudouridine synthase activity
LO004_RS00635	COG0251	oxidation-reduction process
LO004_RS00640	COG1113	amino acid transport
LO004_RS00645	COG1113	amino acid transport
LO004_RS00665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LO004_RS00670	COG1960	acyl-CoA dehydrogenase activity
LO004_RS00675	COG1024	Enoyl-CoA hydratase
LO004_RS00680	COG1024	Enoyl-CoA hydratase
LO004_RS00685	COG0477	Major facilitator Superfamily
LO004_RS00690	COG3916	Acyl-homoserine-lactone synthase
LO004_RS00705	COG2197	response regulator
LO004_RS00715	COG1960	acyl-CoA dehydrogenase activity
LO004_RS00720	COG3321	synthase
LO004_RS00720	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
LO004_RS00720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LO004_RS00720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LO004_RS00760	COG0271	Belongs to the BolA IbaG family
LO004_RS00770	COG1192	Involved in chromosome partitioning
LO004_RS00785	COG0586	Pfam SNARE associated Golgi protein
LO004_RS00790	COG2259	Doxx family
LO004_RS00795	COG4399	Belongs to the UPF0754 family
LO004_RS00800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LO004_RS00800	COG0519	Catalyzes the synthesis of GMP from XMP
LO004_RS00845	COG0281	malic enzyme
LO004_RS00855	COG2837	iron assimilation
LO004_RS00860	COG1280	lysine exporter protein (LysE YggA)
LO004_RS00865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LO004_RS00870	COG1121	(ABC) transporter
LO004_RS00940	COG0386	Belongs to the glutathione peroxidase family
LO004_RS00955	COG1309	transcriptional regulator
LO004_RS00960	COG0697	spore germination
LO004_RS00970	COG0758	DNA mediated transformation
LO004_RS01035	COG0625	glutathione transferase activity
LO004_RS01045	COG0733	neurotransmitter:sodium symporter activity
LO004_RS01080	COG0583	DNA-binding transcription factor activity
LO004_RS01085	COG2233	PERMEase
LO004_RS01100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS01135	COG2814	Major facilitator Superfamily
LO004_RS01140	COG0656	L-ascorbic acid biosynthetic process
LO004_RS01145	COG0583	DNA-binding transcription factor activity
LO004_RS01160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LO004_RS01165	COG1064	alcohol dehydrogenase
LO004_RS01170	COG2818	Glycosylase
LO004_RS01185	COG1194	a g-specific adenine glycosylase
LO004_RS01195	COG0400	carboxylic ester hydrolase activity
LO004_RS01205	COG2983	Belongs to the UPF0260 family
LO004_RS01210	COG2133	pyrroloquinoline quinone binding
LO004_RS01215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LO004_RS01220	COG2116	formate transmembrane transporter activity
LO004_RS01240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LO004_RS01245	COG1335	isochorismatase
LO004_RS01250	COG0385	Bile acid
LO004_RS01255	COG0534	Mate efflux family protein
LO004_RS01260	COG1683	Conserved Protein
LO004_RS01280	COG0625	glutathione transferase activity
LO004_RS01290	COG1113	amino acid transport
LO004_RS01300	COG0523	cobalamin synthesis protein
LO004_RS01310	COG2188	Transcriptional regulator
LO004_RS01340	COG0010	Belongs to the arginase family
LO004_RS01350	COG0546	phosphoglycolate phosphatase activity
LO004_RS01355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LO004_RS01360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LO004_RS01370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LO004_RS01375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LO004_RS01470	COG0534	Mate efflux family protein
LO004_RS01475	COG0436	Aminotransferase
LO004_RS01480	COG2733	membrane
LO004_RS01495	COG2918	glutathione biosynthetic process
LO004_RS01530	COG3150	esterase
LO004_RS01540	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS01545	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
LO004_RS01555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LO004_RS01565	COG2233	PERMEase
LO004_RS01570	COG2351	hydroxyisourate hydrolase activity
LO004_RS01605	COG3706	GGDEF domain
LO004_RS01620	COG1393	Belongs to the ArsC family
LO004_RS01625	COG0708	Exodeoxyribonuclease III
LO004_RS01645	COG0189	ligase activity
LO004_RS01665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LO004_RS01675	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LO004_RS01690	COG4942	peptidase
LO004_RS01700	COG0508	dehydrogenase complex catalyzes the overall conversion of
LO004_RS01710	COG2119	membrane
LO004_RS01715	COG4774	siderophore transport
LO004_RS01720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS01720	COG0426	domain, Protein
LO004_RS01745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LO004_RS01765	COG1902	pentaerythritol trinitrate reductase activity
LO004_RS01770	COG1519	Transferase
LO004_RS01775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LO004_RS01780	COG0668	transmembrane transport
LO004_RS01790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LO004_RS01795	COG1335	isochorismatase
LO004_RS01800	COG1522	sequence-specific DNA binding
LO004_RS01825	COG2205	protein histidine kinase activity
LO004_RS01825	COG0784	Response regulator, receiver
LO004_RS01825	COG2198	Histidine kinase
LO004_RS01830	COG3162	membrane
LO004_RS01835	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LO004_RS01845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LO004_RS01865	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LO004_RS01870	COG1309	transcriptional regulator
LO004_RS01890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LO004_RS01890	COG0351	phosphomethylpyrimidine kinase
LO004_RS01890	COG0352	thiamine-phosphate diphosphorylase activity
LO004_RS01900	COG2814	Major facilitator Superfamily
LO004_RS01915	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LO004_RS01925	COG1113	amino acid transport
LO004_RS01935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LO004_RS01940	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS01950	COG1335	isochorismatase
LO004_RS01980	COG2814	Major facilitator Superfamily
LO004_RS01985	COG0583	DNA-binding transcription factor activity
LO004_RS02005	COG0667	Aldo Keto reductase
LO004_RS02035	COG1733	regulation of RNA biosynthetic process
LO004_RS02040	COG2249	NAD(P)H dehydrogenase (quinone) activity
LO004_RS02105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LO004_RS02145	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LO004_RS02175	COG0427	acetyl-CoA hydrolase
LO004_RS02200	COG0659	secondary active sulfate transmembrane transporter activity
LO004_RS02205	COG4221	oxidoreductase activity
LO004_RS02210	COG2873	o-acetylhomoserine
LO004_RS02215	COG0488	(ABC) transporter
LO004_RS02300	COG0833	amino acid
LO004_RS02345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LO004_RS02350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LO004_RS02365	COG2226	methyltransferase
LO004_RS02415	COG0069	glutamate synthase activity
LO004_RS02415	COG0067	glutamate synthase
LO004_RS02415	COG0070	glutamate synthase
LO004_RS02420	COG0493	'glutamate synthase
LO004_RS02430	COG1704	LemA family
LO004_RS02435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
LO004_RS02455	COG3307	-O-antigen
LO004_RS02475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LO004_RS02490	COG0194	GDP metabolic process
LO004_RS02540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LO004_RS02560	COG5380	lipid catabolic process
LO004_RS02565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LO004_RS02590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LO004_RS02595	COG0277	FAD linked oxidase domain protein
LO004_RS02605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LO004_RS02610	COG2249	NAD(P)H dehydrogenase (quinone) activity
LO004_RS02625	COG1289	transmembrane transporter activity
LO004_RS02635	COG0628	permease
LO004_RS02640	COG1192	Involved in chromosome partitioning
LO004_RS02670	COG0833	amino acid
LO004_RS02675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LO004_RS02680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LO004_RS02690	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS02730	COG0583	DNA-binding transcription factor activity
LO004_RS02790	COG0517	IMP dehydrogenase activity
LO004_RS02795	COG1983	PspC domain protein
LO004_RS02805	COG1960	acyl-CoA dehydrogenase activity
LO004_RS02820	COG0408	coproporphyrinogen oxidase activity
LO004_RS02840	COG0513	Belongs to the DEAD box helicase family
LO004_RS02850	COG1127	ABC transporter
LO004_RS02855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LO004_RS02865	COG2854	intermembrane phospholipid transfer
LO004_RS02875	COG0598	Magnesium transport protein CorA
LO004_RS02885	COG0494	nUDIX hydrolase
LO004_RS02890	COG1040	competence protein
LO004_RS02895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LO004_RS02915	COG1946	Acyl-CoA thioesterase
LO004_RS02920	COG1301	dicarboxylic acid transport
LO004_RS02935	COG1959	2 iron, 2 sulfur cluster binding
LO004_RS02940	COG1017	nitric oxide dioxygenase activity
LO004_RS02940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LO004_RS02950	COG0433	COG0433 Predicted ATPase
LO004_RS02955	COG0626	cystathionine gamma-synthase activity
LO004_RS03110	COG1960	acyl-CoA dehydrogenase activity
LO004_RS03115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LO004_RS03145	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LO004_RS03150	COG0339	signal peptide processing
LO004_RS03155	COG0557	exoribonuclease II activity
LO004_RS03200	COG0179	Fumarylacetoacetate (FAA) hydrolase
LO004_RS03205	COG2169	Transcriptional regulator
LO004_RS03210	COG0697	spore germination
LO004_RS03215	COG1295	ribonuclease BN
LO004_RS03250	COG1702	phosphate starvation-inducible protein PhoH
LO004_RS03260	COG0739	heme binding
LO004_RS03260	COG0741	lytic transglycosylase activity
LO004_RS03260	COG1196	nuclear chromosome segregation
LO004_RS03290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LO004_RS03295	COG1183	phosphatidylcholine synthase activity
LO004_RS03340	COG1960	acyl-CoA dehydrogenase activity
LO004_RS03345	COG1309	transcriptional regulator
LO004_RS03360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LO004_RS03365	COG1960	acyl-CoA dehydrogenase activity
LO004_RS03405	COG2969	positive regulation of protein catabolic process
LO004_RS03415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LO004_RS03425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LO004_RS03430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LO004_RS03435	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LO004_RS03455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LO004_RS03465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LO004_RS03470	COG1408	metallophosphoesterase
LO004_RS03480	COG2199	diguanylate cyclase activity
LO004_RS03540	COG1607	acyl-coa hydrolase
LO004_RS03570	COG2350	Protein conserved in bacteria
LO004_RS03580	COG0613	PHP domain protein
LO004_RS03585	COG3781	membrane
LO004_RS03595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LO004_RS03600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LO004_RS03610	COG1862	Preprotein translocase
LO004_RS03640	COG2205	protein histidine kinase activity
LO004_RS03645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LO004_RS03660	COG0726	polysaccharide deacetylase
LO004_RS03665	COG0438	transferase activity, transferring glycosyl groups
LO004_RS03680	COG1091	dTDP-4-dehydrorhamnose reductase activity
LO004_RS03695	COG1215	transferase activity, transferring glycosyl groups
LO004_RS03745	COG1960	acyl-CoA dehydrogenase activity
LO004_RS03750	COG1960	acyl-CoA dehydrogenase activity
LO004_RS03760	COG2205	protein histidine kinase activity
LO004_RS03765	COG0745	RESPONSE REGULATOR receiver
LO004_RS03770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LO004_RS03790	COG2096	Adenosyltransferase
LO004_RS03795	COG4206	TonB-dependent receptor
LO004_RS03840	COG0285	dihydrofolate synthase activity
LO004_RS03860	COG0450	alkyl hydroperoxide reductase
LO004_RS03875	COG0477	Major facilitator Superfamily
LO004_RS03880	COG1272	protein, Hemolysin III
LO004_RS03910	COG0183	Belongs to the thiolase family
LO004_RS03915	COG2207	Transcriptional regulator
LO004_RS03935	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LO004_RS03955	COG0183	Belongs to the thiolase family
LO004_RS03965	COG2885	chlorophyll binding
LO004_RS03965	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LO004_RS03975	COG1690	Belongs to the RtcB family
LO004_RS03980	COG0833	amino acid
LO004_RS03990	COG2233	PERMEase
LO004_RS03995	COG1217	gtp-binding protein TYPA
LO004_RS04020	COG2094	Belongs to the DNA glycosylase MPG family
LO004_RS04025	COG4772	TonB-dependent receptor
LO004_RS04030	COG1902	pentaerythritol trinitrate reductase activity
LO004_RS04045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LO004_RS04050	COG0354	folic acid binding
LO004_RS04060	COG3189	MarR family transcriptional regulator
LO004_RS04065	COG2824	Alkylphosphonate utilization operon protein PhnA
LO004_RS04070	COG3422	double-strand break repair
LO004_RS04110	COG0840	transmembrane signaling receptor activity
LO004_RS04125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LO004_RS04140	COG5510	response to toxic substance
LO004_RS04150	COG2832	Protein of unknown function (DUF454)
LO004_RS04155	COG1376	ErfK ybiS ycfS ynhG family protein
LO004_RS04195	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LO004_RS04205	COG1289	transmembrane transporter activity
LO004_RS04210	COG2814	Major facilitator Superfamily
LO004_RS04230	COG1115	amino acid carrier protein
LO004_RS04235	COG1752	Esterase of the alpha-beta hydrolase superfamily
LO004_RS04240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LO004_RS04245	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LO004_RS04275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LO004_RS04285	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LO004_RS04290	COG1077	Cell shape determining protein MreB Mrl
LO004_RS04295	COG1792	Involved in formation and maintenance of cell shape
LO004_RS04300	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LO004_RS04305	COG0424	maF-like protein
LO004_RS04310	COG1530	ribonuclease E activity
LO004_RS04320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LO004_RS04330	COG0560	Phosphoserine phosphatase
LO004_RS04340	COG2249	NAD(P)H dehydrogenase (quinone) activity
LO004_RS04365	COG2207	Transcriptional regulator
LO004_RS04385	COG1113	amino acid transport
LO004_RS04390	COG2828	Protein conserved in bacteria
LO004_RS04395	COG0142	geranyltranstransferase activity
LO004_RS04400	COG2315	Protein conserved in bacteria
LO004_RS04415	COG1752	Esterase of the alpha-beta hydrolase superfamily
LO004_RS04435	COG2194	sulfuric ester hydrolase activity
LO004_RS04440	COG0745	RESPONSE REGULATOR receiver
LO004_RS04445	COG0642	Histidine kinase
LO004_RS04455	COG0004	ammonium transporteR
LO004_RS04460	COG0583	DNA-binding transcription factor activity
LO004_RS04480	COG0525	valine-tRNA ligase activity
LO004_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS04500	COG0393	Putative heavy-metal-binding
LO004_RS04505	COG0393	Putative heavy-metal-binding
LO004_RS04510	COG1538	Outer membrane efflux protein
LO004_RS04520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS04525	COG0671	phosphoesterase, PA-phosphatase related
LO004_RS04555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LO004_RS04570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LO004_RS04570	COG1648	precorrin-2 dehydrogenase activity
LO004_RS04575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LO004_RS04580	COG1733	regulation of RNA biosynthetic process
LO004_RS04590	COG0531	amino acid
LO004_RS04605	COG0321	lipoyl(octanoyl) transferase activity
LO004_RS04610	COG2921	Belongs to the UPF0250 family
LO004_RS04645	COG2009	succinate dehydrogenase
LO004_RS04650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LO004_RS04655	COG1053	succinate dehydrogenase
LO004_RS04660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LO004_RS04685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LO004_RS04705	COG2354	Protein conserved in bacteria
LO004_RS04710	COG2321	neutral zinc metallopeptidase
LO004_RS04730	COG2843	Capsule synthesis protein
LO004_RS04745	COG0589	response to stress
LO004_RS04755	COG0251	oxidation-reduction process
LO004_RS04775	COG0505	Belongs to the CarA family
LO004_RS04800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LO004_RS04805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LO004_RS04855	COG0477	Major facilitator Superfamily
LO004_RS04860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LO004_RS04875	COG1597	lipid kinase activity
LO004_RS04880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LO004_RS04905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LO004_RS04910	COG0584	glycerophosphoryl diester phosphodiesterase
LO004_RS04930	COG0741	lytic transglycosylase activity
LO004_RS04950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LO004_RS04965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LO004_RS04990	COG3811	Belongs to the UPF0386 family
LO004_RS05000	COG0778	Nitroreductase
LO004_RS05015	COG1929	Belongs to the glycerate kinase type-1 family
LO004_RS05020	COG0243	molybdopterin cofactor binding
LO004_RS05025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LO004_RS05030	COG3339	Conserved Protein
LO004_RS05040	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LO004_RS05055	COG1115	amino acid carrier protein
LO004_RS05060	COG1113	amino acid transport
LO004_RS05070	COG0019	diaminopimelate decarboxylase activity
LO004_RS05080	COG2267	carboxylic ester hydrolase activity
LO004_RS05085	COG1280	lysine exporter protein (LysE YggA)
LO004_RS05090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LO004_RS05120	COG0463	Glycosyl transferase, family 2
LO004_RS05140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS05170	COG4591	ABC-type transport system involved in lipoprotein release permease component
LO004_RS05175	COG1136	(ABC) transporter
LO004_RS05180	COG2333	competence protein COMEC
LO004_RS05180	COG0658	competence protein
LO004_RS05190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LO004_RS05190	COG0616	signal peptide processing
LO004_RS05195	COG0596	Alpha beta hydrolase
LO004_RS05200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LO004_RS05210	COG0628	permease
LO004_RS05245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LO004_RS05265	COG0823	Involved in the tonB-independent uptake of proteins
LO004_RS05285	COG0824	Thioesterase
LO004_RS05290	COG1473	amidohydrolase
LO004_RS05310	COG0047	phosphoribosylformylglycinamidine synthase activity
LO004_RS05310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LO004_RS05315	COG2814	Major facilitator Superfamily
LO004_RS05330	COG1024	Enoyl-CoA hydratase
LO004_RS05335	COG1051	belongs to the nudix hydrolase family
LO004_RS05335	COG1056	cytidyltransferase-related domain
LO004_RS05345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LO004_RS05360	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LO004_RS05375	COG4625	pathogenesis
LO004_RS05380	COG0583	DNA-binding transcription factor activity
LO004_RS05385	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LO004_RS05390	COG4208	sulfate ABC transporter
LO004_RS05395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LO004_RS05405	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LO004_RS05410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LO004_RS05415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LO004_RS05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LO004_RS05445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LO004_RS05455	COG0681	Belongs to the peptidase S26 family
LO004_RS05470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LO004_RS05480	COG1381	Involved in DNA repair and RecF pathway recombination
LO004_RS05485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LO004_RS05495	COG4221	oxidoreductase activity
LO004_RS05525	COG0436	Aminotransferase
LO004_RS05545	COG0556	nucleotide-excision repair
LO004_RS05600	COG2070	2-Nitropropane dioxygenase
LO004_RS05630	COG1215	transferase activity, transferring glycosyl groups
LO004_RS05645	COG0415	Belongs to the DNA photolyase family
LO004_RS05655	COG1252	NADH dehydrogenase
LO004_RS05660	COG1686	Belongs to the peptidase S11 family
LO004_RS05675	COG1187	pseudouridine synthase activity
LO004_RS05700	COG0477	Major facilitator Superfamily
LO004_RS05705	COG0583	DNA-binding transcription factor activity
LO004_RS05710	COG1823	symporter activity
LO004_RS05720	COG0612	Peptidase, M16
LO004_RS05745	COG0352	thiamine-phosphate diphosphorylase activity
LO004_RS05780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LO004_RS05795	COG1309	transcriptional regulator
LO004_RS05805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LO004_RS05810	COG0076	glutamate decarboxylase activity
LO004_RS05820	COG1522	sequence-specific DNA binding
LO004_RS05825	COG3961	Belongs to the TPP enzyme family
LO004_RS05830	COG1113	amino acid transport
LO004_RS05835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LO004_RS05840	COG0573	inorganic phosphate transmembrane transporter activity
LO004_RS05850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LO004_RS05855	COG0616	signal peptide processing
LO004_RS05890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LO004_RS05895	COG1686	Belongs to the peptidase S11 family
LO004_RS05920	COG0583	DNA-binding transcription factor activity
LO004_RS05925	COG1067	ATP-dependent peptidase activity
LO004_RS05950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LO004_RS05970	COG1966	Carbon starvation protein
LO004_RS05975	COG2879	small protein
LO004_RS06025	COG1741	Belongs to the pirin family
LO004_RS06035	COG2964	Protein conserved in bacteria
LO004_RS06050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LO004_RS06055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LO004_RS06060	COG4605	iron ion homeostasis
LO004_RS06065	COG4604	ABC transporter, ATP-binding protein
LO004_RS06070	COG4607	ABC-type enterochelin transport system periplasmic component
LO004_RS06075	COG4774	siderophore transport
LO004_RS06085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LO004_RS06090	COG1021	2,3-dihydroxybenzoate-AMP ligase
LO004_RS06095	COG3433	isochorismatase activity
LO004_RS06095	COG1535	isochorismatase
LO004_RS06110	COG1132	(ABC) transporter
LO004_RS06115	COG1132	(ABC) transporter
LO004_RS06120	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
LO004_RS06130	COG1169	isochorismate synthase
LO004_RS06145	COG3739	integral membrane protein
LO004_RS06165	COG0302	gtp cyclohydrolase
LO004_RS06175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LO004_RS06205	COG0308	aminopeptidase N
LO004_RS06210	COG0512	Glutamine amidotransferase of anthranilate synthase
LO004_RS06225	COG0174	glutamine synthetase
LO004_RS06235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LO004_RS06270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LO004_RS06275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LO004_RS06280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LO004_RS06300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LO004_RS06305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LO004_RS06310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LO004_RS06325	COG1960	acyl-CoA dehydrogenase activity
LO004_RS06330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LO004_RS06335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LO004_RS06345	COG2223	nitrite transmembrane transporter activity
LO004_RS06355	COG0024	Methionine aminopeptidase
LO004_RS06360	COG0052	Belongs to the universal ribosomal protein uS2 family
LO004_RS06375	COG2207	Transcriptional regulator
LO004_RS06400	COG2951	lytic endotransglycosylase activity
LO004_RS06405	COG0772	Belongs to the SEDS family
LO004_RS06420	COG0842	Transport permease protein
LO004_RS06425	COG1131	(ABC) transporter
LO004_RS06430	COG0582	viral genome integration into host DNA
LO004_RS06470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LO004_RS06625	COG3728	DNA packaging
LO004_RS06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS06840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LO004_RS06845	COG0826	peptidase U32
LO004_RS06865	COG1720	tRNA m6t6A37 methyltransferase activity
LO004_RS06875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LO004_RS06890	COG0642	Histidine kinase
LO004_RS06900	COG0494	nUDIX hydrolase
LO004_RS06910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LO004_RS06915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LO004_RS06920	COG3139	Protein of unknown function (DUF1315)
LO004_RS06930	COG1301	dicarboxylic acid transport
LO004_RS06935	COG1960	acyl-CoA dehydrogenase activity
LO004_RS06950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LO004_RS06960	COG2195	Cleaves the N-terminal amino acid of tripeptides
LO004_RS06980	COG1690	Belongs to the RtcB family
LO004_RS06985	COG1234	tRNA 3'-trailer cleavage
LO004_RS06990	COG4650	regulator
LO004_RS07020	COG2363	Small membrane protein
LO004_RS07045	COG0513	Belongs to the DEAD box helicase family
LO004_RS07055	COG0778	Nitroreductase
LO004_RS07085	COG1286	toxin biosynthetic process
LO004_RS07110	COG4783	chaperone-mediated protein folding
LO004_RS07115	COG1610	YqeY-like protein
LO004_RS07170	COG2831	hemolysin activation secretion protein
LO004_RS07175	COG3210	domain, Protein
LO004_RS07185	COG3210	domain, Protein
LO004_RS07280	COG3111	PFAM Bacterial OB fold (BOF) protein
LO004_RS07305	COG3243	poly(R)-hydroxyalkanoic acid synthase
LO004_RS07310	COG0786	glutamate:sodium symporter activity
LO004_RS07320	COG2186	Transcriptional regulator
LO004_RS07370	COG0477	Major facilitator Superfamily
LO004_RS07375	COG1051	belongs to the nudix hydrolase family
LO004_RS07410	COG2995	paraquat-inducible protein a
LO004_RS07415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LO004_RS07415	COG3008	intermembrane lipid transfer
LO004_RS07425	COG2351	hydroxyisourate hydrolase activity
LO004_RS07465	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LO004_RS07475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LO004_RS07480	COG0642	Histidine kinase
LO004_RS07485	COG0745	RESPONSE REGULATOR receiver
LO004_RS07505	COG1794	racemase activity, acting on amino acids and derivatives
LO004_RS07535	COG1301	dicarboxylic acid transport
LO004_RS07545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LO004_RS07550	COG2011	ABC-type metal ion transport system permease component
LO004_RS07555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LO004_RS07560	COG1464	Belongs to the NlpA lipoprotein family
LO004_RS07565	COG0151	Belongs to the GarS family
LO004_RS07570	COG0138	bifunctional purine biosynthesis protein purh
LO004_RS07575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LO004_RS07605	COG2308	Evidence 4 Homologs of previously reported genes of
LO004_RS07615	COG1305	Transglutaminase-like
LO004_RS07625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LO004_RS07630	COG0305	Participates in initiation and elongation during chromosome replication
LO004_RS07655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LO004_RS07665	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LO004_RS07670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LO004_RS07695	COG0726	polysaccharide deacetylase
LO004_RS07695	COG1649	PFAM Uncharacterised BCR, COG1649
LO004_RS07700	COG1215	transferase activity, transferring glycosyl groups
LO004_RS07705	COG3658	cytochrome
LO004_RS07715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LO004_RS07730	COG0583	DNA-binding transcription factor activity
LO004_RS07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LO004_RS07755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LO004_RS07770	COG1960	acyl-CoA dehydrogenase activity
LO004_RS07775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LO004_RS07780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS07805	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LO004_RS07810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LO004_RS07820	COG2205	protein histidine kinase activity
LO004_RS07825	COG0745	RESPONSE REGULATOR receiver
LO004_RS07830	COG0174	glutamine synthetase
LO004_RS07850	COG0729	surface antigen
LO004_RS07875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LO004_RS07880	COG2814	Major facilitator Superfamily
LO004_RS07895	COG0583	DNA-binding transcription factor activity
LO004_RS07910	COG1187	pseudouridine synthase activity
LO004_RS07930	COG0802	atpase or kinase
LO004_RS07935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LO004_RS07945	COG1923	regulation of RNA biosynthetic process
LO004_RS07950	COG0697	spore germination
LO004_RS07975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LO004_RS07980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LO004_RS07980	COG0519	Catalyzes the synthesis of GMP from XMP
LO004_RS07985	COG4302	ethanolamine ammonia-lyase activity
LO004_RS07990	COG4303	Ethanolamine ammonia lyase large subunit
LO004_RS07995	COG0531	amino acid
LO004_RS08015	COG1454	alcohol dehydrogenase
LO004_RS08020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LO004_RS08045	COG0308	aminopeptidase N
LO004_RS08085	COG1605	Chorismate mutase
LO004_RS08100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LO004_RS08115	COG1309	transcriptional regulator
LO004_RS08125	COG0668	transmembrane transport
LO004_RS08155	COG4773	Receptor
LO004_RS08180	COG0488	(ABC) transporter
LO004_RS08185	COG0589	response to stress
LO004_RS08210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LO004_RS08220	COG3135	benzoate transporter
LO004_RS08225	COG1522	sequence-specific DNA binding
LO004_RS08235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LO004_RS08240	COG0583	DNA-binding transcription factor activity
LO004_RS08250	COG0183	Belongs to the thiolase family
LO004_RS08260	COG2030	dehydratase
LO004_RS08265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LO004_RS08290	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LO004_RS08300	COG0824	Thioesterase
LO004_RS08305	COG1454	alcohol dehydrogenase
LO004_RS08315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LO004_RS08345	COG0069	glutamate synthase activity
LO004_RS08365	COG2814	Major facilitator Superfamily
LO004_RS08380	COG0511	ligase activity, forming carbon-carbon bonds
LO004_RS08400	COG1116	anion transmembrane transporter activity
LO004_RS08400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LO004_RS08405	COG0745	RESPONSE REGULATOR receiver
LO004_RS08415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LO004_RS08415	COG2146	nitrite reductase [NAD(P)H] activity
LO004_RS08420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LO004_RS08425	COG0243	molybdopterin cofactor binding
LO004_RS08435	COG0243	molybdopterin cofactor binding
LO004_RS08440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LO004_RS08455	COG0521	Mo-molybdopterin cofactor biosynthetic process
LO004_RS08455	COG0315	cyclic pyranopterin monophosphate synthase activity
LO004_RS08460	COG0303	'Molybdopterin
LO004_RS08470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LO004_RS08475	COG0697	spore germination
LO004_RS08495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LO004_RS08500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LO004_RS08555	COG2204	response regulator
LO004_RS08560	COG3852	Histidine kinase
LO004_RS08580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LO004_RS08585	COG0575	Belongs to the CDS family
LO004_RS08600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LO004_RS08620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LO004_RS08635	COG2137	regulation of response to DNA damage stimulus
LO004_RS08645	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LO004_RS08650	COG1011	Hydrolase
LO004_RS08685	COG1113	amino acid transport
LO004_RS08705	COG0659	secondary active sulfate transmembrane transporter activity
LO004_RS08710	COG2135	peptidase activity
LO004_RS08725	COG5001	Diguanylate cyclase
LO004_RS08725	COG3300	MHYT domain
LO004_RS08745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LO004_RS08745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LO004_RS08745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LO004_RS08750	COG1105	Belongs to the carbohydrate kinase PfkB family
LO004_RS08755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LO004_RS08755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LO004_RS08785	COG0024	Methionine aminopeptidase
LO004_RS08790	COG0583	DNA-binding transcription factor activity
LO004_RS08800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LO004_RS08805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LO004_RS08810	COG0516	GMP reductase activity
LO004_RS08810	COG0517	IMP dehydrogenase activity
LO004_RS08835	COG0552	protein localization to endoplasmic reticulum
LO004_RS08845	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
LO004_RS08855	COG4890	Cyd operon protein YbgT
LO004_RS08860	COG1294	oxidase, subunit
LO004_RS08875	COG1585	Membrane protein implicated in regulation of membrane protease activity
LO004_RS08885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LO004_RS08890	COG4774	siderophore transport
LO004_RS08905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LO004_RS08910	COG0569	domain protein
LO004_RS08915	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LO004_RS08945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LO004_RS08950	COG0542	response to heat
LO004_RS08975	COG0446	pyridine nucleotide-disulphide oxidoreductase
LO004_RS08975	COG1902	pentaerythritol trinitrate reductase activity
LO004_RS09020	COG2323	membrane
LO004_RS09025	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LO004_RS09035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LO004_RS09040	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LO004_RS09045	COG0183	Belongs to the thiolase family
LO004_RS09050	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LO004_RS09055	COG0596	Alpha beta hydrolase
LO004_RS09060	COG2271	Major facilitator Superfamily
LO004_RS09065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LO004_RS09070	COG3485	protocatechuate 3,4-dioxygenase
LO004_RS09075	COG3485	protocatechuate 3,4-dioxygenase
LO004_RS09080	COG0710	3-dehydroquinate dehydratase activity
LO004_RS09085	COG3420	alginic acid biosynthetic process
LO004_RS09090	COG3659	wide pore channel activity
LO004_RS09095	COG4993	Dehydrogenase
LO004_RS09105	COG2391	methyltransferase activity
LO004_RS09120	COG1414	Transcriptional regulator
LO004_RS09125	COG0583	DNA-binding transcription factor activity
LO004_RS09130	COG1960	acyl-CoA dehydrogenase activity
LO004_RS09155	COG2814	Major facilitator Superfamily
LO004_RS09165	COG0154	amidase activity
LO004_RS09185	COG4638	Rieske (2fe-2S)
LO004_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS09205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS09215	COG3733	amine oxidase
LO004_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS09235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LO004_RS09240	COG0183	Belongs to the thiolase family
LO004_RS09245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LO004_RS09250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LO004_RS09260	COG4829	muconolactone delta-isomerase
LO004_RS09265	COG4948	Mandelate Racemase Muconate Lactonizing
LO004_RS09270	COG0583	DNA-binding transcription factor activity
LO004_RS09280	COG2186	Transcriptional regulator
LO004_RS09300	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS09315	COG0446	pyridine nucleotide-disulphide oxidoreductase
LO004_RS09315	COG1902	pentaerythritol trinitrate reductase activity
LO004_RS09330	COG0789	Transcriptional regulator
LO004_RS09355	COG1309	transcriptional regulator
LO004_RS09360	COG0583	DNA-binding transcription factor activity
LO004_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS09385	COG1960	acyl-CoA dehydrogenase activity
LO004_RS09395	COG0318	PFAM AMP-dependent synthetase and ligase
LO004_RS09440	COG2188	Transcriptional regulator
LO004_RS09455	COG0583	DNA-binding transcription factor activity
LO004_RS09480	COG1566	PFAM secretion protein HlyD family protein
LO004_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS09500	COG0129	dihydroxy-acid dehydratase activity
LO004_RS09510	COG0583	DNA-binding transcription factor activity
LO004_RS09515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LO004_RS09525	COG2084	Dehydrogenase
LO004_RS09530	COG2207	Transcriptional regulator
LO004_RS09535	COG1064	alcohol dehydrogenase
LO004_RS09545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LO004_RS09550	COG1120	ATPase activity
LO004_RS09570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LO004_RS09625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LO004_RS09670	COG3621	Patatin-like phospholipase
LO004_RS09700	COG1073	alpha beta
LO004_RS09725	COG2207	Transcriptional regulator
LO004_RS09735	COG5002	protein histidine kinase activity
LO004_RS09740	COG0745	RESPONSE REGULATOR receiver
LO004_RS09745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS09750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LO004_RS09755	COG1538	Outer membrane efflux protein
LO004_RS09765	COG2072	flavoprotein involved in K transport
LO004_RS09785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LO004_RS09875	COG3539	Fimbrial protein
LO004_RS09900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LO004_RS09910	COG0753	catalase activity
LO004_RS09925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LO004_RS09985	COG1535	isochorismatase
LO004_RS09985	COG3433	isochorismatase activity
LO004_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS09995	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LO004_RS10000	COG4149	molybdate abc transporter
LO004_RS10005	COG0725	ABC transporter, periplasmic molybdate-binding protein
LO004_RS10015	COG4638	Rieske (2fe-2S)
LO004_RS10020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LO004_RS10025	COG0543	2 iron, 2 sulfur cluster binding
LO004_RS10025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LO004_RS10040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS10050	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS10065	COG2207	Transcriptional regulator
LO004_RS10070	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS10075	COG2610	gluconate transmembrane transporter activity
LO004_RS10105	COG0583	DNA-binding transcription factor activity
LO004_RS10120	COG2031	fatty acid transporter
LO004_RS10125	COG0183	Belongs to the thiolase family
LO004_RS10130	COG0583	DNA-binding transcription factor activity
LO004_RS10135	COG0583	DNA-binding transcription factor activity
LO004_RS10150	COG1027	Aspartate ammonia-lyase
LO004_RS10160	COG0477	Major facilitator Superfamily
LO004_RS10180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LO004_RS10185	COG4521	taurine ABC transporter
LO004_RS10200	COG2188	Transcriptional regulator
LO004_RS10210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LO004_RS10215	COG1733	regulation of RNA biosynthetic process
LO004_RS10220	COG3708	Transcriptional regulator
LO004_RS10220	COG2207	Transcriptional regulator
LO004_RS10235	COG0730	response to heat
LO004_RS10260	COG3781	membrane
LO004_RS10265	COG1063	alcohol dehydrogenase
LO004_RS10275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LO004_RS10280	COG0508	dehydrogenase complex catalyzes the overall conversion of
LO004_RS10285	COG0022	dehydrogenase e1 component
LO004_RS10290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LO004_RS10295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LO004_RS10310	COG3706	GGDEF domain
LO004_RS10325	COG0133	tryptophan synthase activity
LO004_RS10335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LO004_RS10370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LO004_RS10395	COG2226	methyltransferase
LO004_RS10450	COG0842	Transport permease protein
LO004_RS10455	COG0842	Transport permease protein
LO004_RS10460	COG1131	(ABC) transporter
LO004_RS10475	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LO004_RS10480	COG4773	Receptor
LO004_RS10500	COG0730	response to heat
LO004_RS10505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LO004_RS10520	COG0406	alpha-ribazole phosphatase activity
LO004_RS10525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
LO004_RS10540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LO004_RS10570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LO004_RS10580	COG4264	IucA IucC family
LO004_RS10585	COG4264	IucA IucC family
LO004_RS10590	COG2814	Major facilitator Superfamily
LO004_RS10605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LO004_RS10620	COG1960	acyl-CoA dehydrogenase activity
LO004_RS10625	COG1960	acyl-CoA dehydrogenase activity
LO004_RS10630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LO004_RS10635	COG2207	Transcriptional regulator
LO004_RS10640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LO004_RS10645	COG0776	regulation of translation
LO004_RS10670	COG0822	iron-sulfur transferase activity
LO004_RS10675	COG0316	Belongs to the HesB IscA family
LO004_RS10705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LO004_RS10725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LO004_RS10730	COG0702	epimerase
LO004_RS10765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LO004_RS10775	COG0339	signal peptide processing
LO004_RS10785	COG4166	transmembrane transport
LO004_RS10820	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LO004_RS10885	COG1196	nuclear chromosome segregation
LO004_RS10885	COG0739	heme binding
LO004_RS10885	COG0741	lytic transglycosylase activity
LO004_RS11035	COG0305	Participates in initiation and elongation during chromosome replication
LO004_RS11050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LO004_RS11095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LO004_RS11125	COG0776	regulation of translation
LO004_RS11190	COG0084	hydrolase, TatD family'
LO004_RS11210	COG1663	tetraacyldisaccharide 4'-kinase activity
LO004_RS11215	COG1132	(ABC) transporter
LO004_RS11225	COG0811	peptide transport
LO004_RS11230	COG1475	DNA binding
LO004_RS11235	COG1192	Involved in chromosome partitioning
LO004_RS11245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LO004_RS11260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LO004_RS11265	COG0191	fructose-bisphosphate aldolase activity
LO004_RS11285	COG0424	maF-like protein
LO004_RS11290	COG2850	peptidyl-arginine hydroxylation
LO004_RS11300	COG0640	Transcriptional regulator
LO004_RS11310	COG3619	membrane
LO004_RS11315	COG3122	Protein conserved in bacteria
LO004_RS11320	COG1132	(ABC) transporter
LO004_RS11340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LO004_RS11345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LO004_RS11355	COG0506	proline dehydrogenase activity
LO004_RS11355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LO004_RS11355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LO004_RS11360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
LO004_RS11375	COG3698	Phosphodiester glycosidase
LO004_RS11385	COG2353	YceI-like domain
LO004_RS11395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LO004_RS11440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LO004_RS11440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LO004_RS11465	COG3539	Fimbrial protein
LO004_RS11470	COG3121	Chaperone
LO004_RS11495	COG0697	spore germination
LO004_RS11505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LO004_RS11515	COG0583	DNA-binding transcription factor activity
LO004_RS11535	COG1309	transcriptional regulator
LO004_RS11550	COG1522	sequence-specific DNA binding
LO004_RS11560	COG1126	abc transporter atp-binding protein
LO004_RS11565	COG0765	amino acid transport
LO004_RS11570	COG0765	amino acid transport
LO004_RS11600	COG1464	Belongs to the NlpA lipoprotein family
LO004_RS11610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LO004_RS11615	COG2011	ABC-type metal ion transport system permease component
LO004_RS11620	COG0012	GTP binding
LO004_RS11645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LO004_RS11685	COG0386	Belongs to the glutathione peroxidase family
LO004_RS11695	COG0436	Aminotransferase
LO004_RS11735	COG3634	alkyl hydroperoxide reductase activity
LO004_RS11750	COG0583	DNA-binding transcription factor activity
LO004_RS11755	COG0798	PFAM Bile acid sodium symporter
LO004_RS11760	COG0640	Transcriptional regulator
LO004_RS11775	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
LO004_RS11785	COG0583	DNA-binding transcription factor activity
LO004_RS11795	COG1953	Uracil, thiamine, allantoin
LO004_RS11805	COG2175	clavaminate synthase activity
LO004_RS11810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LO004_RS11815	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LO004_RS11820	COG4521	taurine ABC transporter
LO004_RS11830	COG0477	Major facilitator Superfamily
LO004_RS11850	COG1271	oxidase subunit
LO004_RS11855	COG1294	oxidase, subunit
LO004_RS11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LO004_RS11885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LO004_RS11905	COG3052	prosthetic group binding
LO004_RS11910	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LO004_RS11920	COG0583	DNA-binding transcription factor activity
LO004_RS11930	COG2814	Major facilitator Superfamily
LO004_RS11950	COG1346	cytolysis
LO004_RS11960	COG0583	DNA-binding transcription factor activity
LO004_RS11965	COG0625	glutathione transferase activity
LO004_RS11970	COG0625	glutathione transferase activity
LO004_RS11975	COG0583	DNA-binding transcription factor activity
LO004_RS11990	COG1045	serine acetyltransferase
LO004_RS11995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LO004_RS12000	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LO004_RS12005	COG1280	lysine exporter protein (LysE YggA)
LO004_RS12015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LO004_RS12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LO004_RS12025	COG1126	abc transporter atp-binding protein
LO004_RS12030	COG0765	amino acid transport
LO004_RS12035	COG0765	amino acid transport
LO004_RS12055	COG0784	Response regulator, receiver
LO004_RS12055	COG2205	protein histidine kinase activity
LO004_RS12075	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LO004_RS12095	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS12145	COG0583	DNA-binding transcription factor activity
LO004_RS12165	COG0318	PFAM AMP-dependent synthetase and ligase
LO004_RS12170	COG1309	transcriptional regulator
LO004_RS12175	COG1960	acyl-CoA dehydrogenase activity
LO004_RS12180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LO004_RS12185	COG1024	Enoyl-CoA hydratase
LO004_RS12190	COG4770	biotin carboxylase activity
LO004_RS12200	COG0583	DNA-binding transcription factor activity
LO004_RS12215	COG1960	acyl-CoA dehydrogenase activity
LO004_RS12225	COG2814	Major facilitator Superfamily
LO004_RS12235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LO004_RS12240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
LO004_RS12245	COG2814	Major facilitator Superfamily
LO004_RS12250	COG1960	acyl-CoA dehydrogenase activity
LO004_RS12255	COG1024	Enoyl-CoA hydratase
LO004_RS12260	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS12265	COG1250	3-hydroxyacyl-CoA dehydrogenase
LO004_RS12270	COG0183	Belongs to the thiolase family
LO004_RS12285	COG1280	lysine exporter protein (LysE YggA)
LO004_RS12290	COG2192	nodulation
LO004_RS12305	COG1024	Enoyl-CoA hydratase
LO004_RS12315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LO004_RS12320	COG1960	acyl-CoA dehydrogenase activity
LO004_RS12325	COG2814	Major facilitator Superfamily
LO004_RS12330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LO004_RS12335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LO004_RS12350	COG3842	ATPase activity
LO004_RS12355	COG1840	ABC-type Fe3 transport system, periplasmic component
LO004_RS12365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LO004_RS12370	COG1414	Transcriptional regulator
LO004_RS12380	COG0583	DNA-binding transcription factor activity
LO004_RS12385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LO004_RS12390	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS12400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
LO004_RS12410	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS12415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LO004_RS12420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS12425	COG2267	carboxylic ester hydrolase activity
LO004_RS12445	COG3038	cytochrome b561
LO004_RS12450	COG0753	catalase activity
LO004_RS12465	COG0210	DNA helicase
LO004_RS12470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LO004_RS12475	COG2050	protein possibly involved in aromatic compounds catabolism
LO004_RS12485	COG3327	negative regulation of DNA-templated transcription, initiation
LO004_RS12490	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
LO004_RS12495	COG0183	Belongs to the thiolase family
LO004_RS12500	COG1250	3-hydroxyacyl-CoA dehydrogenase
LO004_RS12505	COG1024	Enoyl-CoA hydratase
LO004_RS12510	COG1024	Enoyl-CoA hydratase
LO004_RS12515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LO004_RS12520	COG2151	metal-sulfur cluster biosynthetic enzyme
LO004_RS12525	COG3396	Phenylacetate-CoA oxygenase
LO004_RS12535	COG3396	Phenylacetate-CoA oxygenase
LO004_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS12540	COG2030	dehydratase
LO004_RS12545	COG1760	l-serine dehydratase
LO004_RS12550	COG0531	amino acid
LO004_RS12555	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS12580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LO004_RS12600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LO004_RS12610	COG0789	Transcriptional regulator
LO004_RS12620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LO004_RS12635	COG2807	transmembrane transport
LO004_RS12640	COG0590	tRNA wobble adenosine to inosine editing
LO004_RS12760	COG1116	anion transmembrane transporter activity
LO004_RS12765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LO004_RS12775	COG0864	Transcriptional regulator
LO004_RS12785	COG1733	regulation of RNA biosynthetic process
LO004_RS12790	COG2249	NAD(P)H dehydrogenase (quinone) activity
LO004_RS12795	COG0439	Biotin carboxylase
LO004_RS12810	COG1063	alcohol dehydrogenase
LO004_RS12820	COG1309	transcriptional regulator
LO004_RS12835	COG3210	domain, Protein
LO004_RS12840	COG2831	hemolysin activation secretion protein
LO004_RS12845	COG0038	chloride channel
LO004_RS12850	COG4770	biotin carboxylase activity
LO004_RS12870	COG1914	H( )-stimulated, divalent metal cation uptake system
LO004_RS12875	COG0583	DNA-binding transcription factor activity
LO004_RS12935	COG1250	3-hydroxyacyl-CoA dehydrogenase
LO004_RS12960	COG2814	Major facilitator Superfamily
LO004_RS12975	COG1560	Kdo2-lipid A biosynthetic process
LO004_RS12985	COG5006	permease, DMT superfamily
LO004_RS12990	COG1522	sequence-specific DNA binding
LO004_RS13005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LO004_RS13015	COG4122	O-methyltransferase activity
LO004_RS13045	COG1538	Outer membrane efflux protein
LO004_RS13050	COG1137	ATPase activity
LO004_RS13055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LO004_RS13065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LO004_RS13070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LO004_RS13070	COG0517	IMP dehydrogenase activity
LO004_RS13205	COG3728	DNA packaging
LO004_RS13205	COG5484	DNA packaging
LO004_RS13340	COG2814	Major facilitator Superfamily
LO004_RS13375	COG1278	Cold shock
LO004_RS13380	COG1280	lysine exporter protein (LysE YggA)
LO004_RS13410	COG1570	exodeoxyribonuclease VII activity
LO004_RS13460	COG0583	DNA-binding transcription factor activity
LO004_RS13470	COG4638	Rieske (2fe-2S)
LO004_RS13475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
LO004_RS13480	COG0543	2 iron, 2 sulfur cluster binding
LO004_RS13480	COG0633	Ferredoxin
LO004_RS13485	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS13490	COG3135	benzoate transporter
LO004_RS13495	COG2814	Major facilitator Superfamily
LO004_RS13510	COG1643	Atp-dependent helicase
LO004_RS13515	COG0450	alkyl hydroperoxide reductase
LO004_RS13525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LO004_RS13535	COG3634	alkyl hydroperoxide reductase activity
LO004_RS13610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LO004_RS13615	COG0625	glutathione transferase activity
LO004_RS13625	COG2885	chlorophyll binding
LO004_RS13660	COG0542	response to heat
LO004_RS13675	COG1765	OsmC-like protein
LO004_RS13690	COG0667	Aldo Keto reductase
LO004_RS13705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LO004_RS13720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LO004_RS13730	COG0582	viral genome integration into host DNA
LO004_RS13800	COG0739	heme binding
LO004_RS13800	COG1196	nuclear chromosome segregation
LO004_RS13800	COG0741	lytic transglycosylase activity
LO004_RS13840	COG1598	PFAM Uncharacterised protein family UPF0150
LO004_RS14120	COG0527	aspartate kinase activity
LO004_RS14130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LO004_RS14140	COG3038	cytochrome b561
LO004_RS14145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LO004_RS14150	COG2252	PERMEase
LO004_RS14160	COG2072	flavoprotein involved in K transport
LO004_RS14175	COG1741	Belongs to the pirin family
LO004_RS14180	COG1309	transcriptional regulator
LO004_RS14190	COG0300	oxidoreductase activity
LO004_RS14195	COG2072	flavoprotein involved in K transport
LO004_RS14200	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LO004_RS14245	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LO004_RS14260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LO004_RS14275	COG2814	Major facilitator Superfamily
LO004_RS14280	COG1024	Enoyl-CoA hydratase
LO004_RS14285	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS14295	COG1960	acyl-CoA dehydrogenase activity
LO004_RS14320	COG2186	Transcriptional regulator
LO004_RS14325	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS14335	COG4948	Mandelate Racemase Muconate Lactonizing
LO004_RS14340	COG2271	Major facilitator Superfamily
LO004_RS14345	COG2721	sulfolactate sulfo-lyase activity
LO004_RS14350	COG0697	spore germination
LO004_RS14385	COG1113	amino acid transport
LO004_RS14405	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS14425	COG0531	amino acid
LO004_RS14435	COG1113	amino acid transport
LO004_RS14495	COG3209	COG3209 Rhs family protein
LO004_RS14530	COG1902	pentaerythritol trinitrate reductase activity
LO004_RS14530	COG0446	pyridine nucleotide-disulphide oxidoreductase
LO004_RS14560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LO004_RS14580	COG4172	Belongs to the ABC transporter superfamily
LO004_RS14585	COG4239	(ABC) transporter, permease
LO004_RS14590	COG4174	ABC transporter (Permease)
LO004_RS14600	COG1388	LysM domain
LO004_RS14600	COG0741	lytic transglycosylase activity
LO004_RS14600	COG1388	LysM domain
LO004_RS14600	COG0741	lytic transglycosylase activity
LO004_RS14605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LO004_RS14645	COG0583	DNA-binding transcription factor activity
LO004_RS14650	COG1279	arginine transmembrane transporter activity
LO004_RS14670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LO004_RS14675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LO004_RS14680	COG0006	proline dipeptidase activity
LO004_RS14720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LO004_RS14740	COG3384	dioxygenase
LO004_RS14750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LO004_RS14755	COG2878	Part of a membrane complex involved in electron transport
LO004_RS14760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LO004_RS14785	COG0768	penicillin binding
LO004_RS14790	COG0742	ribosomal rna small subunit methyltransferase
LO004_RS14805	COG0830	nickel cation binding
LO004_RS14815	COG0804	urea catabolic process
LO004_RS14855	COG1253	flavin adenine dinucleotide binding
LO004_RS14860	COG2851	Citrate transporter
LO004_RS14910	COG1773	rubredoxin
LO004_RS14915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LO004_RS14925	COG0583	DNA-binding transcription factor activity
LO004_RS14955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LO004_RS14960	COG4181	ATPase activity
LO004_RS15005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LO004_RS15025	COG0306	phosphate transporter
LO004_RS15035	COG3958	Transketolase
LO004_RS15040	COG3959	Transketolase, thiamine diphosphate binding domain
LO004_RS15045	COG2271	Major facilitator Superfamily
LO004_RS15050	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS15055	COG0583	DNA-binding transcription factor activity
LO004_RS15070	COG2223	nitrite transmembrane transporter activity
LO004_RS15075	COG2207	Transcriptional regulator
LO004_RS15080	COG2066	Belongs to the glutaminase family
LO004_RS15085	COG0242	peptide deformylase activity
LO004_RS15090	COG0477	Major facilitator Superfamily
LO004_RS15100	COG0028	Belongs to the TPP enzyme family
LO004_RS15115	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS15120	COG2267	carboxylic ester hydrolase activity
LO004_RS15130	COG2271	Major facilitator Superfamily
LO004_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
LO004_RS15165	COG1414	Transcriptional regulator
LO004_RS15180	COG1024	Enoyl-CoA hydratase
LO004_RS15190	COG1215	transferase activity, transferring glycosyl groups
LO004_RS15195	COG1649	PFAM Uncharacterised BCR, COG1649
LO004_RS15195	COG0726	polysaccharide deacetylase
LO004_RS15205	COG4681	YaeQ
LO004_RS15215	COG0523	cobalamin synthesis protein
LO004_RS15225	COG1607	acyl-coa hydrolase
LO004_RS15235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LO004_RS15240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LO004_RS15245	COG1309	transcriptional regulator
LO004_RS15270	COG2040	homocysteine
LO004_RS15275	COG0531	amino acid
LO004_RS15300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LO004_RS15305	COG0477	Major facilitator Superfamily
LO004_RS15335	COG1401	restriction endodeoxyribonuclease activity
LO004_RS15355	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LO004_RS15365	COG0405	Gamma-glutamyltransferase
LO004_RS15370	COG2814	Major facilitator Superfamily
LO004_RS15380	COG2050	protein possibly involved in aromatic compounds catabolism
LO004_RS15395	COG1090	epimerase
LO004_RS15415	COG0420	3'-5' exonuclease activity
LO004_RS15440	COG0735	belongs to the Fur family
LO004_RS15445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LO004_RS15465	COG0121	glutamine amidotransferase
LO004_RS15480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LO004_RS15490	COG0210	DNA helicase
LO004_RS15495	COG2885	chlorophyll binding
LO004_RS15500	COG0204	Acyl-transferase
LO004_RS15515	COG2894	cell division
LO004_RS15530	COG1280	lysine exporter protein (LysE YggA)
LO004_RS15535	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LO004_RS15535	COG1674	ftsk spoiiie
LO004_RS15540	COG0492	ferredoxin-NADP+ reductase activity
LO004_RS15545	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LO004_RS15555	COG0456	acetyltransferase
LO004_RS15600	COG1981	membrane
LO004_RS15615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LO004_RS15615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LO004_RS15635	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS15645	COG0657	acetylesterase activity
LO004_RS15655	COG0473	3-isopropylmalate dehydrogenase activity
LO004_RS15660	COG0583	DNA-binding transcription factor activity
LO004_RS15680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LO004_RS15705	COG0564	pseudouridine synthase activity
LO004_RS15715	COG0358	DNA primase activity
LO004_RS15730	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LO004_RS15760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LO004_RS15790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LO004_RS15800	COG0352	thiamine-phosphate diphosphorylase activity
LO004_RS15800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LO004_RS15800	COG0351	phosphomethylpyrimidine kinase
LO004_RS15805	COG1652	LysM domain
LO004_RS15830	COG1399	metal-binding, possibly nucleic acid-binding protein
LO004_RS15835	COG3101	peptidyl-lysine hydroxylation
LO004_RS15840	COG0009	L-threonylcarbamoyladenylate synthase
LO004_RS15845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LO004_RS15850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LO004_RS15865	COG4106	trans-aconitate 2-methyltransferase activity
LO004_RS15880	COG0596	Alpha beta hydrolase
LO004_RS15880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LO004_RS15880	COG2226	methyltransferase
LO004_RS15885	COG1877	trehalose-phosphatase activity
LO004_RS15890	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LO004_RS15895	COG2223	nitrite transmembrane transporter activity
LO004_RS15915	COG1196	nuclear chromosome segregation
LO004_RS15925	COG0730	response to heat
LO004_RS15940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LO004_RS15950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LO004_RS16000	COG0489	protein tyrosine kinase activity
LO004_RS16010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LO004_RS16010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LO004_RS16040	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LO004_RS16045	COG2081	HI0933 family
LO004_RS16055	COG0668	transmembrane transport
LO004_RS16075	COG0583	DNA-binding transcription factor activity
LO004_RS16095	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LO004_RS16100	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LO004_RS16130	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LO004_RS16170	COG0745	RESPONSE REGULATOR receiver
LO004_RS16190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LO004_RS16205	COG0384	phenazine biosynthesis protein PhzF
LO004_RS16235	COG1309	transcriptional regulator
LO004_RS16240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LO004_RS16255	COG0583	DNA-binding transcription factor activity
LO004_RS16285	COG0583	DNA-binding transcription factor activity
LO004_RS16300	COG0583	DNA-binding transcription factor activity
LO004_RS16305	COG1053	succinate dehydrogenase
LO004_RS16315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LO004_RS16320	COG2814	Major facilitator Superfamily
LO004_RS16325	COG1960	acyl-CoA dehydrogenase activity
LO004_RS16330	COG0583	DNA-binding transcription factor activity
LO004_RS16335	COG1063	alcohol dehydrogenase
LO004_RS16365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LO004_RS16370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LO004_RS16375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LO004_RS16395	COG2132	Multicopper oxidase
LO004_RS16405	COG0561	phosphatase activity
LO004_RS16410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LO004_RS16420	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LO004_RS16435	COG1214	PFAM Peptidase M22, glycoprotease
LO004_RS16485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LO004_RS16495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LO004_RS16500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LO004_RS16505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LO004_RS16565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LO004_RS16575	COG1846	Transcriptional regulator
LO004_RS16580	COG1764	response to oxidative stress
LO004_RS16620	COG0037	tRNA processing
LO004_RS16630	COG0248	Ppx GppA phosphatase
LO004_RS16660	COG0072	phenylalanine-tRNA ligase activity
LO004_RS16705	COG1238	metal cluster binding
LO004_RS16710	COG0625	glutathione transferase activity
LO004_RS16725	COG0318	PFAM AMP-dependent synthetase and ligase
LO004_RS16730	COG3028	Belongs to the UPF0307 family
LO004_RS16735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LO004_RS16755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LO004_RS16760	COG0617	tRNA 3'-terminal CCA addition
LO004_RS16765	COG1555	photosystem II stabilization
LO004_RS16770	COG3956	TIGRFAM MazG family protein
LO004_RS16780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LO004_RS16800	COG5002	protein histidine kinase activity
LO004_RS16800	COG2205	protein histidine kinase activity
LO004_RS16800	COG0784	Response regulator, receiver
LO004_RS16805	COG1024	Enoyl-CoA hydratase
LO004_RS16810	COG2084	Dehydrogenase
LO004_RS16815	COG3622	Belongs to the hyi family
LO004_RS16845	COG0697	spore germination
LO004_RS16855	COG2814	Major facilitator Superfamily
LO004_RS16880	COG2072	flavoprotein involved in K transport
LO004_RS16885	COG0492	ferredoxin-NADP+ reductase activity
LO004_RS16890	COG0431	NADPH-dependent FMN reductase
LO004_RS16895	COG0798	PFAM Bile acid sodium symporter
LO004_RS16905	COG0640	Transcriptional regulator
LO004_RS16940	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LO004_RS16965	COG2132	Multicopper oxidase
LO004_RS16980	COG2205	protein histidine kinase activity
LO004_RS17065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LO004_RS17075	COG0583	DNA-binding transcription factor activity
LO004_RS17085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LO004_RS17095	COG0084	hydrolase, TatD family'
LO004_RS17110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LO004_RS17140	COG0440	acetolactate synthase activity
LO004_RS17145	COG0028	Belongs to the TPP enzyme family
LO004_RS17170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LO004_RS17175	COG1136	(ABC) transporter
LO004_RS17175	COG0577	efflux transmembrane transporter activity
LO004_RS17180	COG1538	Outer membrane efflux protein
LO004_RS17195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LO004_RS17200	COG1162	GTPase activity
LO004_RS17210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LO004_RS17250	COG1426	Protein conserved in bacteria
LO004_RS17285	COG0793	Belongs to the peptidase S41A family
LO004_RS17300	COG2267	carboxylic ester hydrolase activity
LO004_RS17310	COG1012	belongs to the aldehyde dehydrogenase family
LO004_RS17315	COG3265	gluconokinase activity
LO004_RS17325	COG0800	Aldolase
LO004_RS17335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LO004_RS17340	COG0857	belongs to the CobB CobQ family
LO004_RS17340	COG0280	phosphate acetyltransferase
LO004_RS17345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LO004_RS17345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LO004_RS17365	COG0740	serine-type endopeptidase activity
LO004_RS17375	COG4774	siderophore transport
LO004_RS17385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LO004_RS17395	COG2813	Specifically methylates the guanine in position
LO004_RS17395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LO004_RS17540	COG0788	formyltetrahydrofolate deformylase activity
LO004_RS17565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LO004_RS17565	COG4651	solute:proton antiporter activity
LO004_RS17585	COG0724	RNA recognition motif
LO004_RS17590	COG0210	DNA helicase
LO004_RS17615	COG1733	regulation of RNA biosynthetic process
LO004_RS17625	COG2900	Belongs to the SlyX family
LO004_RS17630	COG0488	(ABC) transporter
LO004_RS17635	COG1280	lysine exporter protein (LysE YggA)
LO004_RS17640	COG1560	Kdo2-lipid A biosynthetic process
LO004_RS17650	COG1301	dicarboxylic acid transport
LO004_RS17705	COG0473	3-isopropylmalate dehydrogenase activity
LO004_RS17760	COG0583	DNA-binding transcription factor activity
LO004_RS17770	COG0625	glutathione transferase activity
LO004_RS17775	COG2378	regulation of single-species biofilm formation
LO004_RS17780	COG0546	phosphoglycolate phosphatase activity
LO004_RS17790	COG1530	ribonuclease E activity
LO004_RS17795	COG0318	PFAM AMP-dependent synthetase and ligase
LO004_RS17805	COG0583	DNA-binding transcription factor activity
LO004_RS17810	COG4221	oxidoreductase activity
LO004_RS17815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LO004_RS17825	COG0534	Mate efflux family protein
LO004_RS17840	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LO004_RS17865	COG0493	'glutamate synthase
LO004_RS17865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LO004_RS17875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LO004_RS17880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LO004_RS17895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LO004_RS17905	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
LO004_RS17905	COG0644	oxidoreductase
LO004_RS17915	COG0425	Belongs to the sulfur carrier protein TusA family
LO004_RS17920	COG4535	Mg2 and Co2 transporter CorC
LO004_RS17930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LO004_RS17950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LO004_RS17955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LO004_RS17955	COG0475	glutathione-regulated potassium exporter activity
LO004_RS17970	COG0484	heat shock protein binding
LO004_RS17975	COG0789	Transcriptional regulator
LO004_RS17980	COG0598	Magnesium transport protein CorA
LO004_RS17995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LO004_RS18000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LO004_RS18005	COG1074	ATP-dependent DNA helicase activity
LO004_RS18010	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LO004_RS18030	COG2226	methyltransferase
LO004_RS18050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LO004_RS18065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LO004_RS18065	COG2111	Na H antiporter
LO004_RS18070	COG1006	Multisubunit Na H antiporter MnhC subunit
LO004_RS18075	COG0651	ATP synthesis coupled electron transport
LO004_RS18080	COG1863	multisubunit Na H antiporter MnhE subunit
LO004_RS18085	COG2212	antiporter activity
LO004_RS18090	COG1320	monovalent cation:proton antiporter activity
LO004_RS18105	COG0195	Participates in both transcription termination and antitermination
LO004_RS18155	COG0237	dephospho-CoA kinase activity
LO004_RS18165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LO004_RS18180	COG0497	DNA recombination
LO004_RS18190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LO004_RS18220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LO004_RS18220	COG2169	Transcriptional regulator
LO004_RS18225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LO004_RS18285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LO004_RS18295	COG3293	Transposase
LO004_RS18305	COG0326	Molecular chaperone. Has ATPase activity
LO004_RS18320	COG2056	Na+-H+ antiporter family
LO004_RS18325	COG0596	Alpha beta hydrolase
LO004_RS18420	COG0546	phosphoglycolate phosphatase activity
LO004_RS18425	COG1716	ATPase activity
LO004_RS18470	COG0181	hydroxymethylbilane synthase activity
LO004_RS18480	COG3275	phosphorelay sensor kinase activity
LO004_RS18500	COG1538	Outer membrane efflux protein
LO004_RS18505	COG0697	spore germination
LO004_RS18530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LO004_RS18535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LO004_RS18540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LO004_RS18545	COG0772	Belongs to the SEDS family
LO004_RS18570	COG4974	Belongs to the 'phage' integrase family
LO004_RS18575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LO004_RS18585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LO004_RS18595	COG2197	response regulator
LO004_RS18610	COG0793	Belongs to the peptidase S41A family
LO004_RS18615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LO004_RS18620	COG0795	lipopolysaccharide-transporting ATPase activity
LO004_RS18660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LO004_RS18660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LO004_RS18670	COG0004	ammonium transporteR
LO004_RS18675	COG0347	Belongs to the P(II) protein family
LO004_RS18685	COG0606	chelatase, subunit chli
LO004_RS18700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LO004_RS18720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LO004_RS18735	COG0318	PFAM AMP-dependent synthetase and ligase
LO004_RS18745	COG0477	Major facilitator Superfamily
LO004_RS18750	COG2860	membrane
LO004_RS18760	COG1253	flavin adenine dinucleotide binding
LO004_RS18770	COG0477	Major facilitator Superfamily
LO004_RS18780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LO004_RS18820	COG0655	NAD(P)H dehydrogenase (quinone) activity
LO004_RS18830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LO004_RS18865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LO004_RS18870	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LO004_RS18875	COG0596	Alpha beta hydrolase
LO004_RS18900	COG0488	(ABC) transporter
LO004_RS18905	COG0586	Pfam SNARE associated Golgi protein
LO004_RS18915	COG0187	DNA topoisomerase II activity
LO004_RS18925	COG0592	DNA-directed DNA polymerase activity
LO004_RS19025	COG0501	Belongs to the peptidase M48B family
LO004_RS19085	COG0589	response to stress
LO004_RS19090	COG0659	secondary active sulfate transmembrane transporter activity
LO004_RS19120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LO004_RS19200	COG0798	PFAM Bile acid sodium symporter
LO004_RS19235	COG4691	Plasmid stability protein
LO004_RS19295	COG0640	Transcriptional regulator
LO004_RS19320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LO004_RS19390	COG1525	nuclease
LO004_RS19510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LO004_RS19560	COG1192	Involved in chromosome partitioning
LO004_RS19575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LO004_RS19605	COG0739	heme binding
LO004_RS19860	COG0358	DNA primase activity
LO004_RS19920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LO004_RS19965	COG0587	DNA-directed DNA polymerase activity
LO004_RS19980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LO004_RS19980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LO004_RS20030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LO004_RS20030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LO004_RS20035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LO004_RS20080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LO004_RS20180	COG0789	Transcriptional regulator
LO004_RS20265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LO004_RS20285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LO004_RS20295	COG0783	Belongs to the Dps family