locus-tag	class	description
DLE02_RS00005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DLE02_RS00010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DLE02_RS00015	COG0596	Alpha beta hydrolase
DLE02_RS00040	COG0488	(ABC) transporter
DLE02_RS00045	COG0586	Pfam SNARE associated Golgi protein
DLE02_RS00055	COG0187	DNA topoisomerase II activity
DLE02_RS00065	COG0592	DNA-directed DNA polymerase activity
DLE02_RS00090	COG0706	membrane insertase activity
DLE02_RS00105	COG1230	cation diffusion facilitator family transporter
DLE02_RS00110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLE02_RS00125	COG0402	S-adenosylhomocysteine deaminase activity
DLE02_RS00135	COG0754	glutathionylspermidine amidase activity
DLE02_RS00150	COG0861	Integral membrane protein TerC family
DLE02_RS00155	COG0671	phosphoesterase, PA-phosphatase related
DLE02_RS00165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DLE02_RS00180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DLE02_RS00185	COG2951	lytic endotransglycosylase activity
DLE02_RS00215	COG0583	DNA-binding transcription factor activity
DLE02_RS00235	COG0657	acetylesterase activity
DLE02_RS00240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DLE02_RS00280	COG1047	Peptidyl-prolyl cis-trans
DLE02_RS00290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DLE02_RS00295	COG0196	riboflavin kinase activity
DLE02_RS00305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DLE02_RS00310	COG1309	transcriptional regulator
DLE02_RS00315	COG1116	anion transmembrane transporter activity
DLE02_RS00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLE02_RS00325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLE02_RS00330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLE02_RS00335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLE02_RS00355	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS00360	COG0546	phosphoglycolate phosphatase activity
DLE02_RS00420	COG3023	N-Acetylmuramoyl-L-alanine amidase
DLE02_RS00425	COG0728	peptidoglycan biosynthetic process
DLE02_RS00450	COG1596	polysaccharide export
DLE02_RS00455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DLE02_RS00485	COG0438	transferase activity, transferring glycosyl groups
DLE02_RS00510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DLE02_RS00515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DLE02_RS00530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DLE02_RS00535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE02_RS00545	COG2186	Transcriptional regulator
DLE02_RS00555	COG0277	FAD linked oxidase domain protein
DLE02_RS00560	COG1448	Aminotransferase
DLE02_RS00565	COG1802	Transcriptional regulator
DLE02_RS00580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DLE02_RS00665	COG0564	pseudouridine synthase activity
DLE02_RS00705	COG0251	oxidation-reduction process
DLE02_RS00710	COG1113	amino acid transport
DLE02_RS00715	COG1113	amino acid transport
DLE02_RS00735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE02_RS00740	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS00745	COG1024	Enoyl-CoA hydratase
DLE02_RS00750	COG1024	Enoyl-CoA hydratase
DLE02_RS00755	COG0477	Major facilitator Superfamily
DLE02_RS00760	COG3916	Acyl-homoserine-lactone synthase
DLE02_RS00770	COG2197	response regulator
DLE02_RS00780	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS00785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLE02_RS00785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DLE02_RS00785	COG3321	synthase
DLE02_RS00785	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DLE02_RS00825	COG0271	Belongs to the BolA IbaG family
DLE02_RS00835	COG1192	Involved in chromosome partitioning
DLE02_RS00850	COG0586	Pfam SNARE associated Golgi protein
DLE02_RS00855	COG2259	Doxx family
DLE02_RS00860	COG4399	Belongs to the UPF0754 family
DLE02_RS00865	COG0519	Catalyzes the synthesis of GMP from XMP
DLE02_RS00865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE02_RS00910	COG0281	malic enzyme
DLE02_RS00915	COG2837	iron assimilation
DLE02_RS00920	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS00925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DLE02_RS00930	COG1121	(ABC) transporter
DLE02_RS01000	COG0386	Belongs to the glutathione peroxidase family
DLE02_RS01015	COG1309	transcriptional regulator
DLE02_RS01020	COG0697	spore germination
DLE02_RS01030	COG0758	DNA mediated transformation
DLE02_RS01100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DLE02_RS01110	COG0655	NAD(P)H dehydrogenase (quinone) activity
DLE02_RS01150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DLE02_RS01160	COG2814	Major facilitator Superfamily
DLE02_RS01170	COG1253	flavin adenine dinucleotide binding
DLE02_RS01175	COG3012	SEC-C Motif Domain Protein
DLE02_RS01180	COG2860	membrane
DLE02_RS01185	COG0477	Major facilitator Superfamily
DLE02_RS01195	COG0318	PFAM AMP-dependent synthetase and ligase
DLE02_RS01210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DLE02_RS01225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE02_RS01270	COG2072	flavoprotein involved in K transport
DLE02_RS01275	COG0492	ferredoxin-NADP+ reductase activity
DLE02_RS01280	COG0431	NADPH-dependent FMN reductase
DLE02_RS01285	COG0798	PFAM Bile acid sodium symporter
DLE02_RS01295	COG0640	Transcriptional regulator
DLE02_RS01310	COG0789	Transcriptional regulator
DLE02_RS01335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DLE02_RS01420	COG0789	Transcriptional regulator
DLE02_RS01440	COG0697	spore germination
DLE02_RS01580	COG0789	Transcriptional regulator
DLE02_RS01605	COG0659	secondary active sulfate transmembrane transporter activity
DLE02_RS01625	COG0347	Belongs to the P(II) protein family
DLE02_RS01630	COG0004	ammonium transporteR
DLE02_RS01640	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLE02_RS01640	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DLE02_RS01680	COG0795	lipopolysaccharide-transporting ATPase activity
DLE02_RS01685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DLE02_RS01690	COG0793	Belongs to the peptidase S41A family
DLE02_RS01705	COG2197	response regulator
DLE02_RS01715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DLE02_RS01725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLE02_RS01730	COG4974	Belongs to the 'phage' integrase family
DLE02_RS01755	COG0772	Belongs to the SEDS family
DLE02_RS01760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLE02_RS01765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DLE02_RS01770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLE02_RS01795	COG0697	spore germination
DLE02_RS01800	COG1538	Outer membrane efflux protein
DLE02_RS01820	COG3275	phosphorelay sensor kinase activity
DLE02_RS01830	COG0181	hydroxymethylbilane synthase activity
DLE02_RS01875	COG1716	ATPase activity
DLE02_RS01880	COG0546	phosphoglycolate phosphatase activity
DLE02_RS01975	COG0596	Alpha beta hydrolase
DLE02_RS01980	COG2056	Na+-H+ antiporter family
DLE02_RS01995	COG0326	Molecular chaperone. Has ATPase activity
DLE02_RS02010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DLE02_RS02075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DLE02_RS02080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLE02_RS02080	COG2169	Transcriptional regulator
DLE02_RS02110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DLE02_RS02120	COG0497	DNA recombination
DLE02_RS02135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLE02_RS02145	COG0237	dephospho-CoA kinase activity
DLE02_RS02195	COG0195	Participates in both transcription termination and antitermination
DLE02_RS02210	COG1320	monovalent cation:proton antiporter activity
DLE02_RS02215	COG2212	antiporter activity
DLE02_RS02220	COG1863	multisubunit Na H antiporter MnhE subunit
DLE02_RS02225	COG0651	ATP synthesis coupled electron transport
DLE02_RS02230	COG1006	Multisubunit Na H antiporter MnhC subunit
DLE02_RS02235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DLE02_RS02235	COG2111	Na H antiporter
DLE02_RS02250	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DLE02_RS02255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLE02_RS02270	COG2226	methyltransferase
DLE02_RS02290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DLE02_RS02295	COG1074	ATP-dependent DNA helicase activity
DLE02_RS02300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DLE02_RS02305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLE02_RS02320	COG0598	Magnesium transport protein CorA
DLE02_RS02325	COG0789	Transcriptional regulator
DLE02_RS02330	COG0484	heat shock protein binding
DLE02_RS02340	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DLE02_RS02345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLE02_RS02345	COG0475	glutathione-regulated potassium exporter activity
DLE02_RS02350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DLE02_RS02370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE02_RS02380	COG4535	Mg2 and Co2 transporter CorC
DLE02_RS02385	COG0425	Belongs to the sulfur carrier protein TusA family
DLE02_RS02390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
DLE02_RS02390	COG0644	oxidoreductase
DLE02_RS02400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLE02_RS02415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE02_RS02420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DLE02_RS02460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DLE02_RS02475	COG0534	Mate efflux family protein
DLE02_RS02485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DLE02_RS02490	COG4221	oxidoreductase activity
DLE02_RS02495	COG0583	DNA-binding transcription factor activity
DLE02_RS02510	COG0318	PFAM AMP-dependent synthetase and ligase
DLE02_RS02515	COG1530	ribonuclease E activity
DLE02_RS02525	COG0546	phosphoglycolate phosphatase activity
DLE02_RS02530	COG2378	regulation of single-species biofilm formation
DLE02_RS02535	COG0625	glutathione transferase activity
DLE02_RS02545	COG0583	DNA-binding transcription factor activity
DLE02_RS02610	COG0473	3-isopropylmalate dehydrogenase activity
DLE02_RS02665	COG1301	dicarboxylic acid transport
DLE02_RS02675	COG1560	Kdo2-lipid A biosynthetic process
DLE02_RS02680	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS02685	COG0488	(ABC) transporter
DLE02_RS02690	COG2900	Belongs to the SlyX family
DLE02_RS02700	COG1733	regulation of RNA biosynthetic process
DLE02_RS02725	COG0210	DNA helicase
DLE02_RS02730	COG0724	RNA recognition motif
DLE02_RS02750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLE02_RS02750	COG4651	solute:proton antiporter activity
DLE02_RS02775	COG0788	formyltetrahydrofolate deformylase activity
DLE02_RS02875	COG2813	Specifically methylates the guanine in position
DLE02_RS02875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLE02_RS02885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DLE02_RS02895	COG4774	siderophore transport
DLE02_RS02905	COG0740	serine-type endopeptidase activity
DLE02_RS02925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DLE02_RS02925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DLE02_RS02930	COG0857	belongs to the CobB CobQ family
DLE02_RS02930	COG0280	phosphate acetyltransferase
DLE02_RS02935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DLE02_RS02945	COG0800	Aldolase
DLE02_RS02955	COG3265	gluconokinase activity
DLE02_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS02970	COG2267	carboxylic ester hydrolase activity
DLE02_RS02985	COG0793	Belongs to the peptidase S41A family
DLE02_RS03020	COG1426	Protein conserved in bacteria
DLE02_RS03065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DLE02_RS03075	COG0318	PFAM AMP-dependent synthetase and ligase
DLE02_RS03090	COG2986	histidine ammonia-lyase
DLE02_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS03135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DLE02_RS03155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DLE02_RS03165	COG1162	GTPase activity
DLE02_RS03170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DLE02_RS03185	COG1538	Outer membrane efflux protein
DLE02_RS03190	COG0577	efflux transmembrane transporter activity
DLE02_RS03190	COG1136	(ABC) transporter
DLE02_RS03195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS03220	COG0028	Belongs to the TPP enzyme family
DLE02_RS03225	COG0440	acetolactate synthase activity
DLE02_RS03255	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DLE02_RS03270	COG0084	hydrolase, TatD family'
DLE02_RS03285	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DLE02_RS03295	COG0583	DNA-binding transcription factor activity
DLE02_RS03305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DLE02_RS03310	COG2814	Major facilitator Superfamily
DLE02_RS03320	COG0697	spore germination
DLE02_RS03350	COG3622	Belongs to the hyi family
DLE02_RS03355	COG2084	Dehydrogenase
DLE02_RS03360	COG1024	Enoyl-CoA hydratase
DLE02_RS03365	COG2205	protein histidine kinase activity
DLE02_RS03365	COG0784	Response regulator, receiver
DLE02_RS03365	COG5002	protein histidine kinase activity
DLE02_RS03385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLE02_RS03395	COG3956	TIGRFAM MazG family protein
DLE02_RS03400	COG1555	photosystem II stabilization
DLE02_RS03405	COG0617	tRNA 3'-terminal CCA addition
DLE02_RS03410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DLE02_RS03430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLE02_RS03435	COG3028	Belongs to the UPF0307 family
DLE02_RS03440	COG0318	PFAM AMP-dependent synthetase and ligase
DLE02_RS03455	COG0625	glutathione transferase activity
DLE02_RS03460	COG1238	metal cluster binding
DLE02_RS03505	COG0072	phenylalanine-tRNA ligase activity
DLE02_RS03535	COG0248	Ppx GppA phosphatase
DLE02_RS03545	COG0037	tRNA processing
DLE02_RS03585	COG1764	response to oxidative stress
DLE02_RS03590	COG1846	Transcriptional regulator
DLE02_RS03600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLE02_RS03660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DLE02_RS03665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DLE02_RS03670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DLE02_RS03680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DLE02_RS03730	COG1214	PFAM Peptidase M22, glycoprotease
DLE02_RS03755	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DLE02_RS03760	COG0561	phosphatase activity
DLE02_RS03770	COG2132	Multicopper oxidase
DLE02_RS03775	COG3667	copper resistance
DLE02_RS03790	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DLE02_RS03795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DLE02_RS03800	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DLE02_RS03830	COG1063	alcohol dehydrogenase
DLE02_RS03835	COG0583	DNA-binding transcription factor activity
DLE02_RS03840	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS03845	COG2814	Major facilitator Superfamily
DLE02_RS03850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DLE02_RS03860	COG1053	succinate dehydrogenase
DLE02_RS03865	COG0583	DNA-binding transcription factor activity
DLE02_RS03880	COG0583	DNA-binding transcription factor activity
DLE02_RS03910	COG0583	DNA-binding transcription factor activity
DLE02_RS03925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLE02_RS03950	COG0384	phenazine biosynthesis protein PhzF
DLE02_RS03975	COG4993	Dehydrogenase
DLE02_RS04045	COG2205	protein histidine kinase activity
DLE02_RS04055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLE02_RS04075	COG0745	RESPONSE REGULATOR receiver
DLE02_RS04115	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DLE02_RS04145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DLE02_RS04150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DLE02_RS04170	COG0583	DNA-binding transcription factor activity
DLE02_RS04190	COG0668	transmembrane transport
DLE02_RS04200	COG2081	HI0933 family
DLE02_RS04205	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DLE02_RS04235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE02_RS04235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DLE02_RS04245	COG0489	protein tyrosine kinase activity
DLE02_RS04295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DLE02_RS04305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DLE02_RS04320	COG0730	response to heat
DLE02_RS04330	COG1196	nuclear chromosome segregation
DLE02_RS04350	COG2223	nitrite transmembrane transporter activity
DLE02_RS04355	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DLE02_RS04360	COG1877	trehalose-phosphatase activity
DLE02_RS04365	COG0596	Alpha beta hydrolase
DLE02_RS04365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLE02_RS04365	COG2226	methyltransferase
DLE02_RS04380	COG4106	trans-aconitate 2-methyltransferase activity
DLE02_RS04395	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DLE02_RS04400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DLE02_RS04405	COG0009	L-threonylcarbamoyladenylate synthase
DLE02_RS04410	COG3101	peptidyl-lysine hydroxylation
DLE02_RS04415	COG1399	metal-binding, possibly nucleic acid-binding protein
DLE02_RS04440	COG1652	LysM domain
DLE02_RS04445	COG0352	thiamine-phosphate diphosphorylase activity
DLE02_RS04445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DLE02_RS04445	COG0351	phosphomethylpyrimidine kinase
DLE02_RS04455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DLE02_RS04485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLE02_RS04515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DLE02_RS04530	COG0358	DNA primase activity
DLE02_RS04540	COG0564	pseudouridine synthase activity
DLE02_RS04565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DLE02_RS04585	COG0583	DNA-binding transcription factor activity
DLE02_RS04590	COG0473	3-isopropylmalate dehydrogenase activity
DLE02_RS04600	COG0657	acetylesterase activity
DLE02_RS04610	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS04630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DLE02_RS04630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DLE02_RS04645	COG1981	membrane
DLE02_RS04690	COG0456	acetyltransferase
DLE02_RS04700	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DLE02_RS04705	COG0492	ferredoxin-NADP+ reductase activity
DLE02_RS04710	COG1674	ftsk spoiiie
DLE02_RS04710	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DLE02_RS04715	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS04735	COG2894	cell division
DLE02_RS04750	COG0204	Acyl-transferase
DLE02_RS04755	COG2885	chlorophyll binding
DLE02_RS04760	COG0210	DNA helicase
DLE02_RS04770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DLE02_RS04785	COG0121	glutamine amidotransferase
DLE02_RS04805	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DLE02_RS04810	COG0735	belongs to the Fur family
DLE02_RS04835	COG0420	3'-5' exonuclease activity
DLE02_RS04855	COG1090	epimerase
DLE02_RS04870	COG2050	protein possibly involved in aromatic compounds catabolism
DLE02_RS04880	COG2814	Major facilitator Superfamily
DLE02_RS04885	COG0405	Gamma-glutamyltransferase
DLE02_RS04895	COG0582	viral genome integration into host DNA
DLE02_RS04950	COG0629	single-stranded DNA binding
DLE02_RS04980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DLE02_RS05010	COG0477	Major facilitator Superfamily
DLE02_RS05015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE02_RS05025	COG1595	DNA-templated transcription, initiation
DLE02_RS05080	COG0531	amino acid
DLE02_RS05085	COG2040	homocysteine
DLE02_RS05110	COG1309	transcriptional regulator
DLE02_RS05115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLE02_RS05120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLE02_RS05130	COG1607	acyl-coa hydrolase
DLE02_RS05140	COG0523	cobalamin synthesis protein
DLE02_RS05150	COG4681	YaeQ
DLE02_RS05160	COG1649	PFAM Uncharacterised BCR, COG1649
DLE02_RS05160	COG0726	polysaccharide deacetylase
DLE02_RS05165	COG1215	transferase activity, transferring glycosyl groups
DLE02_RS05175	COG1024	Enoyl-CoA hydratase
DLE02_RS05190	COG1414	Transcriptional regulator
DLE02_RS05210	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS05220	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLE02_RS05225	COG2271	Major facilitator Superfamily
DLE02_RS05235	COG2267	carboxylic ester hydrolase activity
DLE02_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS05255	COG0028	Belongs to the TPP enzyme family
DLE02_RS05265	COG0477	Major facilitator Superfamily
DLE02_RS05270	COG0242	peptide deformylase activity
DLE02_RS05275	COG2066	Belongs to the glutaminase family
DLE02_RS05280	COG2207	Transcriptional regulator
DLE02_RS05285	COG2223	nitrite transmembrane transporter activity
DLE02_RS05300	COG0583	DNA-binding transcription factor activity
DLE02_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS05310	COG2271	Major facilitator Superfamily
DLE02_RS05315	COG3959	Transketolase, thiamine diphosphate binding domain
DLE02_RS05320	COG3958	Transketolase
DLE02_RS05330	COG0306	phosphate transporter
DLE02_RS05350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLE02_RS05395	COG4181	ATPase activity
DLE02_RS05400	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DLE02_RS05425	COG0583	DNA-binding transcription factor activity
DLE02_RS05435	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLE02_RS05440	COG1773	rubredoxin
DLE02_RS05490	COG2851	Citrate transporter
DLE02_RS05495	COG1253	flavin adenine dinucleotide binding
DLE02_RS05535	COG0804	urea catabolic process
DLE02_RS05545	COG0830	nickel cation binding
DLE02_RS05560	COG0742	ribosomal rna small subunit methyltransferase
DLE02_RS05565	COG0768	penicillin binding
DLE02_RS05590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DLE02_RS05595	COG2878	Part of a membrane complex involved in electron transport
DLE02_RS05600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLE02_RS05610	COG3384	dioxygenase
DLE02_RS05635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DLE02_RS05845	COG5410	chromosome segregation
DLE02_RS05940	COG0739	heme binding
DLE02_RS05940	COG1196	nuclear chromosome segregation
DLE02_RS05940	COG0741	lytic transglycosylase activity
DLE02_RS05980	COG0582	viral genome integration into host DNA
DLE02_RS05995	COG0174	glutamine synthetase
DLE02_RS06005	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DLE02_RS06040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DLE02_RS06045	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DLE02_RS06050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLE02_RS06070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLE02_RS06075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DLE02_RS06080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DLE02_RS06095	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS06100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLE02_RS06105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLE02_RS06115	COG2223	nitrite transmembrane transporter activity
DLE02_RS06125	COG0024	Methionine aminopeptidase
DLE02_RS06130	COG0052	Belongs to the universal ribosomal protein uS2 family
DLE02_RS06145	COG2207	Transcriptional regulator
DLE02_RS06170	COG2951	lytic endotransglycosylase activity
DLE02_RS06175	COG0772	Belongs to the SEDS family
DLE02_RS06190	COG0842	Transport permease protein
DLE02_RS06195	COG1131	(ABC) transporter
DLE02_RS06240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS06255	COG4215	(ABC) transporter
DLE02_RS06260	COG4160	amino acid transport
DLE02_RS06265	COG4598	ABC transporter
DLE02_RS06275	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DLE02_RS06280	COG0826	peptidase U32
DLE02_RS06285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE02_RS06300	COG1720	tRNA m6t6A37 methyltransferase activity
DLE02_RS06310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DLE02_RS06325	COG0642	Histidine kinase
DLE02_RS06335	COG0494	nUDIX hydrolase
DLE02_RS06345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DLE02_RS06350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DLE02_RS06355	COG3139	Protein of unknown function (DUF1315)
DLE02_RS06360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DLE02_RS06365	COG1301	dicarboxylic acid transport
DLE02_RS06370	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS06375	COG2819	hydrolase of the alpha beta superfamily
DLE02_RS06385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DLE02_RS06395	COG2195	Cleaves the N-terminal amino acid of tripeptides
DLE02_RS06400	COG1234	tRNA 3'-trailer cleavage
DLE02_RS06430	COG2363	Small membrane protein
DLE02_RS06455	COG0513	Belongs to the DEAD box helicase family
DLE02_RS06465	COG0778	Nitroreductase
DLE02_RS06495	COG1286	toxin biosynthetic process
DLE02_RS06520	COG4783	chaperone-mediated protein folding
DLE02_RS06525	COG1610	YqeY-like protein
DLE02_RS06625	COG3111	PFAM Bacterial OB fold (BOF) protein
DLE02_RS06650	COG3243	poly(R)-hydroxyalkanoic acid synthase
DLE02_RS06655	COG0786	glutamate:sodium symporter activity
DLE02_RS06665	COG2186	Transcriptional regulator
DLE02_RS06715	COG0477	Major facilitator Superfamily
DLE02_RS06745	COG2985	domain, Protein
DLE02_RS06755	COG2995	paraquat-inducible protein a
DLE02_RS06760	COG3008	intermembrane lipid transfer
DLE02_RS06760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DLE02_RS06770	COG1794	racemase activity, acting on amino acids and derivatives
DLE02_RS06800	COG1301	dicarboxylic acid transport
DLE02_RS06810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE02_RS06815	COG2011	ABC-type metal ion transport system permease component
DLE02_RS06820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLE02_RS06825	COG1464	Belongs to the NlpA lipoprotein family
DLE02_RS06830	COG0151	Belongs to the GarS family
DLE02_RS06835	COG0138	bifunctional purine biosynthesis protein purh
DLE02_RS06840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DLE02_RS06870	COG2308	Evidence 4 Homologs of previously reported genes of
DLE02_RS06880	COG1305	Transglutaminase-like
DLE02_RS06890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DLE02_RS06895	COG0305	Participates in initiation and elongation during chromosome replication
DLE02_RS06920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DLE02_RS06930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DLE02_RS06935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DLE02_RS06960	COG0726	polysaccharide deacetylase
DLE02_RS06960	COG1649	PFAM Uncharacterised BCR, COG1649
DLE02_RS06965	COG1215	transferase activity, transferring glycosyl groups
DLE02_RS06970	COG3658	cytochrome
DLE02_RS06980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLE02_RS06995	COG0583	DNA-binding transcription factor activity
DLE02_RS07015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLE02_RS07020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLE02_RS07035	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS07040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE02_RS07045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLE02_RS07070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DLE02_RS07075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DLE02_RS07085	COG2205	protein histidine kinase activity
DLE02_RS07090	COG0745	RESPONSE REGULATOR receiver
DLE02_RS07095	COG0174	glutamine synthetase
DLE02_RS07115	COG0729	surface antigen
DLE02_RS07140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLE02_RS07145	COG2814	Major facilitator Superfamily
DLE02_RS07160	COG0583	DNA-binding transcription factor activity
DLE02_RS07175	COG1187	pseudouridine synthase activity
DLE02_RS07195	COG0802	atpase or kinase
DLE02_RS07200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DLE02_RS07210	COG1923	regulation of RNA biosynthetic process
DLE02_RS07215	COG0697	spore germination
DLE02_RS07230	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLE02_RS07240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DLE02_RS07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DLE02_RS07245	COG0519	Catalyzes the synthesis of GMP from XMP
DLE02_RS07250	COG4302	ethanolamine ammonia-lyase activity
DLE02_RS07255	COG4303	Ethanolamine ammonia lyase large subunit
DLE02_RS07260	COG0531	amino acid
DLE02_RS07280	COG1454	alcohol dehydrogenase
DLE02_RS07285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DLE02_RS07295	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
DLE02_RS07315	COG0308	aminopeptidase N
DLE02_RS07325	COG4221	oxidoreductase activity
DLE02_RS07335	COG1605	Chorismate mutase
DLE02_RS07355	COG1309	transcriptional regulator
DLE02_RS07365	COG0668	transmembrane transport
DLE02_RS07395	COG4773	Receptor
DLE02_RS07435	COG0300	oxidoreductase activity
DLE02_RS07445	COG1309	transcriptional regulator
DLE02_RS07450	COG1741	Belongs to the pirin family
DLE02_RS07465	COG2072	flavoprotein involved in K transport
DLE02_RS07475	COG2252	PERMEase
DLE02_RS07480	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DLE02_RS07485	COG3038	cytochrome b561
DLE02_RS07495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DLE02_RS07505	COG0527	aspartate kinase activity
DLE02_RS07515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DLE02_RS07525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DLE02_RS07540	COG0667	Aldo Keto reductase
DLE02_RS07555	COG1765	OsmC-like protein
DLE02_RS07570	COG0542	response to heat
DLE02_RS07605	COG2885	chlorophyll binding
DLE02_RS07615	COG0625	glutathione transferase activity
DLE02_RS07620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DLE02_RS07640	COG3634	alkyl hydroperoxide reductase activity
DLE02_RS07650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DLE02_RS07660	COG0450	alkyl hydroperoxide reductase
DLE02_RS07665	COG1643	Atp-dependent helicase
DLE02_RS07680	COG2814	Major facilitator Superfamily
DLE02_RS07685	COG3135	benzoate transporter
DLE02_RS07690	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS07695	COG0633	Ferredoxin
DLE02_RS07695	COG0543	2 iron, 2 sulfur cluster binding
DLE02_RS07700	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DLE02_RS07705	COG4638	Rieske (2fe-2S)
DLE02_RS07715	COG0583	DNA-binding transcription factor activity
DLE02_RS07765	COG1570	exodeoxyribonuclease VII activity
DLE02_RS07795	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS07800	COG1278	Cold shock
DLE02_RS07835	COG2814	Major facilitator Superfamily
DLE02_RS07870	COG0517	IMP dehydrogenase activity
DLE02_RS07870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DLE02_RS07875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DLE02_RS07885	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DLE02_RS07890	COG1137	ATPase activity
DLE02_RS07895	COG1538	Outer membrane efflux protein
DLE02_RS07925	COG4122	O-methyltransferase activity
DLE02_RS07935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DLE02_RS07950	COG1522	sequence-specific DNA binding
DLE02_RS07955	COG5006	permease, DMT superfamily
DLE02_RS07965	COG1560	Kdo2-lipid A biosynthetic process
DLE02_RS07980	COG2814	Major facilitator Superfamily
DLE02_RS08000	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLE02_RS08050	COG0583	DNA-binding transcription factor activity
DLE02_RS08055	COG1914	H( )-stimulated, divalent metal cation uptake system
DLE02_RS08075	COG4770	biotin carboxylase activity
DLE02_RS08080	COG0038	chloride channel
DLE02_RS08100	COG1309	transcriptional regulator
DLE02_RS08110	COG1063	alcohol dehydrogenase
DLE02_RS08125	COG0439	Biotin carboxylase
DLE02_RS08130	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLE02_RS08150	COG0864	Transcriptional regulator
DLE02_RS08160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLE02_RS08165	COG1116	anion transmembrane transporter activity
DLE02_RS08285	COG0590	tRNA wobble adenosine to inosine editing
DLE02_RS08290	COG2807	transmembrane transport
DLE02_RS08305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DLE02_RS08315	COG0789	Transcriptional regulator
DLE02_RS08325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE02_RS08345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLE02_RS08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLE02_RS08370	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS08375	COG0531	amino acid
DLE02_RS08380	COG1760	l-serine dehydratase
DLE02_RS08385	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS08385	COG2030	dehydratase
DLE02_RS08390	COG3396	Phenylacetate-CoA oxygenase
DLE02_RS08395	COG3460	Phenylacetate-CoA oxygenase
DLE02_RS08400	COG3396	Phenylacetate-CoA oxygenase
DLE02_RS08405	COG2151	metal-sulfur cluster biosynthetic enzyme
DLE02_RS08410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE02_RS08415	COG1024	Enoyl-CoA hydratase
DLE02_RS08420	COG1024	Enoyl-CoA hydratase
DLE02_RS08425	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLE02_RS08430	COG0183	Belongs to the thiolase family
DLE02_RS08435	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
DLE02_RS08440	COG3327	negative regulation of DNA-templated transcription, initiation
DLE02_RS08450	COG2050	protein possibly involved in aromatic compounds catabolism
DLE02_RS08485	COG0753	catalase activity
DLE02_RS08490	COG3038	cytochrome b561
DLE02_RS08510	COG2267	carboxylic ester hydrolase activity
DLE02_RS08515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLE02_RS08520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DLE02_RS08525	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS08535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DLE02_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS08550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLE02_RS08555	COG0583	DNA-binding transcription factor activity
DLE02_RS08565	COG1414	Transcriptional regulator
DLE02_RS08570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLE02_RS08580	COG1840	ABC-type Fe3 transport system, periplasmic component
DLE02_RS08585	COG3842	ATPase activity
DLE02_RS08600	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DLE02_RS08605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLE02_RS08610	COG2814	Major facilitator Superfamily
DLE02_RS08615	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS08630	COG1024	Enoyl-CoA hydratase
DLE02_RS08640	COG2814	Major facilitator Superfamily
DLE02_RS08650	COG0183	Belongs to the thiolase family
DLE02_RS08655	COG1250	3-hydroxyacyl-CoA dehydrogenase
DLE02_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS08665	COG1024	Enoyl-CoA hydratase
DLE02_RS08670	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS08675	COG2814	Major facilitator Superfamily
DLE02_RS08680	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLE02_RS08685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLE02_RS08695	COG2814	Major facilitator Superfamily
DLE02_RS08705	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS08720	COG0583	DNA-binding transcription factor activity
DLE02_RS08730	COG4770	biotin carboxylase activity
DLE02_RS08735	COG1024	Enoyl-CoA hydratase
DLE02_RS08740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLE02_RS08745	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS08750	COG1309	transcriptional regulator
DLE02_RS08755	COG0318	PFAM AMP-dependent synthetase and ligase
DLE02_RS08775	COG0583	DNA-binding transcription factor activity
DLE02_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS08845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DLE02_RS08865	COG0784	Response regulator, receiver
DLE02_RS08865	COG2205	protein histidine kinase activity
DLE02_RS08885	COG0765	amino acid transport
DLE02_RS08890	COG0765	amino acid transport
DLE02_RS08895	COG1126	abc transporter atp-binding protein
DLE02_RS08900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLE02_RS08905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DLE02_RS08920	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS08930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DLE02_RS08935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DLE02_RS08940	COG1045	serine acetyltransferase
DLE02_RS08955	COG0583	DNA-binding transcription factor activity
DLE02_RS08960	COG0625	glutathione transferase activity
DLE02_RS08965	COG0625	glutathione transferase activity
DLE02_RS08970	COG0583	DNA-binding transcription factor activity
DLE02_RS08980	COG1346	cytolysis
DLE02_RS09000	COG2814	Major facilitator Superfamily
DLE02_RS09010	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DLE02_RS09015	COG3052	prosthetic group binding
DLE02_RS09035	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DLE02_RS09055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE02_RS09065	COG1294	oxidase, subunit
DLE02_RS09070	COG1271	oxidase subunit
DLE02_RS09090	COG0477	Major facilitator Superfamily
DLE02_RS09100	COG4521	taurine ABC transporter
DLE02_RS09105	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DLE02_RS09110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLE02_RS09115	COG2175	clavaminate synthase activity
DLE02_RS09125	COG1953	Uracil, thiamine, allantoin
DLE02_RS09135	COG0583	DNA-binding transcription factor activity
DLE02_RS09145	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DLE02_RS09160	COG0640	Transcriptional regulator
DLE02_RS09165	COG0798	PFAM Bile acid sodium symporter
DLE02_RS09170	COG0583	DNA-binding transcription factor activity
DLE02_RS09185	COG3634	alkyl hydroperoxide reductase activity
DLE02_RS09225	COG0436	Aminotransferase
DLE02_RS09235	COG0386	Belongs to the glutathione peroxidase family
DLE02_RS09275	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DLE02_RS09300	COG0012	GTP binding
DLE02_RS09305	COG2011	ABC-type metal ion transport system permease component
DLE02_RS09310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLE02_RS09320	COG1464	Belongs to the NlpA lipoprotein family
DLE02_RS09350	COG0765	amino acid transport
DLE02_RS09355	COG0765	amino acid transport
DLE02_RS09360	COG1126	abc transporter atp-binding protein
DLE02_RS09370	COG1522	sequence-specific DNA binding
DLE02_RS09385	COG1309	transcriptional regulator
DLE02_RS09405	COG0583	DNA-binding transcription factor activity
DLE02_RS09415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DLE02_RS09425	COG0697	spore germination
DLE02_RS09450	COG3121	Chaperone
DLE02_RS09455	COG3539	Fimbrial protein
DLE02_RS09480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DLE02_RS09480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DLE02_RS09525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DLE02_RS09535	COG2353	YceI-like domain
DLE02_RS09545	COG3698	Phosphodiester glycosidase
DLE02_RS09560	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DLE02_RS09565	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLE02_RS09565	COG0506	proline dehydrogenase activity
DLE02_RS09565	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DLE02_RS09575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLE02_RS09580	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DLE02_RS09600	COG1132	(ABC) transporter
DLE02_RS09605	COG3122	Protein conserved in bacteria
DLE02_RS09610	COG3619	membrane
DLE02_RS09620	COG0640	Transcriptional regulator
DLE02_RS09630	COG2850	peptidyl-arginine hydroxylation
DLE02_RS09635	COG0424	maF-like protein
DLE02_RS09655	COG0191	fructose-bisphosphate aldolase activity
DLE02_RS09660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DLE02_RS09675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DLE02_RS09685	COG1192	Involved in chromosome partitioning
DLE02_RS09690	COG1475	DNA binding
DLE02_RS09695	COG0811	peptide transport
DLE02_RS09705	COG1132	(ABC) transporter
DLE02_RS09710	COG1663	tetraacyldisaccharide 4'-kinase activity
DLE02_RS09730	COG0084	hydrolase, TatD family'
DLE02_RS09795	COG0776	regulation of translation
DLE02_RS09825	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DLE02_RS09830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DLE02_RS09880	COG0339	signal peptide processing
DLE02_RS09890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DLE02_RS09925	COG0702	epimerase
DLE02_RS09930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLE02_RS09950	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DLE02_RS09980	COG0316	Belongs to the HesB IscA family
DLE02_RS09985	COG0822	iron-sulfur transferase activity
DLE02_RS10010	COG0776	regulation of translation
DLE02_RS10015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DLE02_RS10020	COG2207	Transcriptional regulator
DLE02_RS10025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DLE02_RS10030	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS10035	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS10050	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DLE02_RS10070	COG4264	IucA IucC family
DLE02_RS10075	COG4264	IucA IucC family
DLE02_RS10115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DLE02_RS10130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DLE02_RS10150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DLE02_RS10155	COG0730	response to heat
DLE02_RS10175	COG4773	Receptor
DLE02_RS10180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLE02_RS10195	COG1131	(ABC) transporter
DLE02_RS10200	COG0842	Transport permease protein
DLE02_RS10205	COG0842	Transport permease protein
DLE02_RS10260	COG2226	methyltransferase
DLE02_RS10285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DLE02_RS10320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DLE02_RS10330	COG0133	tryptophan synthase activity
DLE02_RS10345	COG3706	GGDEF domain
DLE02_RS10360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DLE02_RS10365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DLE02_RS10370	COG0022	dehydrogenase e1 component
DLE02_RS10375	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE02_RS10380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLE02_RS10390	COG1063	alcohol dehydrogenase
DLE02_RS10395	COG3781	membrane
DLE02_RS10405	COG3453	Protein conserved in bacteria
DLE02_RS10405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE02_RS10420	COG0730	response to heat
DLE02_RS10435	COG3708	Transcriptional regulator
DLE02_RS10435	COG2207	Transcriptional regulator
DLE02_RS10440	COG1733	regulation of RNA biosynthetic process
DLE02_RS10445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DLE02_RS10455	COG2188	Transcriptional regulator
DLE02_RS10470	COG4521	taurine ABC transporter
DLE02_RS10475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DLE02_RS10495	COG0477	Major facilitator Superfamily
DLE02_RS10505	COG1027	Aspartate ammonia-lyase
DLE02_RS10520	COG0583	DNA-binding transcription factor activity
DLE02_RS10525	COG0583	DNA-binding transcription factor activity
DLE02_RS10530	COG0183	Belongs to the thiolase family
DLE02_RS10535	COG2031	fatty acid transporter
DLE02_RS10540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLE02_RS10550	COG0583	DNA-binding transcription factor activity
DLE02_RS10560	COG2610	gluconate transmembrane transporter activity
DLE02_RS10565	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS10570	COG2207	Transcriptional regulator
DLE02_RS10585	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS10610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE02_RS10610	COG0543	2 iron, 2 sulfur cluster binding
DLE02_RS10615	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DLE02_RS10620	COG4638	Rieske (2fe-2S)
DLE02_RS10630	COG0725	ABC transporter, periplasmic molybdate-binding protein
DLE02_RS10635	COG4149	molybdate abc transporter
DLE02_RS10640	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DLE02_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS10650	COG1535	isochorismatase
DLE02_RS10650	COG3433	isochorismatase activity
DLE02_RS10710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DLE02_RS10725	COG0753	catalase activity
DLE02_RS10735	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DLE02_RS10760	COG3539	Fimbrial protein
DLE02_RS10780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLE02_RS10800	COG2072	flavoprotein involved in K transport
DLE02_RS10810	COG1538	Outer membrane efflux protein
DLE02_RS10815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DLE02_RS10820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS10825	COG0745	RESPONSE REGULATOR receiver
DLE02_RS10830	COG2205	protein histidine kinase activity
DLE02_RS10840	COG2207	Transcriptional regulator
DLE02_RS10855	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS10905	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DLE02_RS11030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DLE02_RS11050	COG1120	ATPase activity
DLE02_RS11055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLE02_RS11065	COG1064	alcohol dehydrogenase
DLE02_RS11080	COG2207	Transcriptional regulator
DLE02_RS11085	COG2084	Dehydrogenase
DLE02_RS11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DLE02_RS11100	COG0583	DNA-binding transcription factor activity
DLE02_RS11110	COG0129	dihydroxy-acid dehydratase activity
DLE02_RS11115	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS11130	COG1566	PFAM secretion protein HlyD family protein
DLE02_RS11165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DLE02_RS11195	COG0583	DNA-binding transcription factor activity
DLE02_RS11210	COG2188	Transcriptional regulator
DLE02_RS11240	COG3210	domain, Protein
DLE02_RS11245	COG2831	hemolysin activation secretion protein
DLE02_RS11255	COG1473	amidohydrolase
DLE02_RS11265	COG0475	glutathione-regulated potassium exporter activity
DLE02_RS11265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DLE02_RS11275	COG0583	DNA-binding transcription factor activity
DLE02_RS11280	COG1335	isochorismatase
DLE02_RS11290	COG1309	transcriptional regulator
DLE02_RS11320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DLE02_RS11330	COG1902	pentaerythritol trinitrate reductase activity
DLE02_RS11330	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLE02_RS11335	COG1846	Transcriptional regulator
DLE02_RS11355	COG0753	catalase activity
DLE02_RS11370	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS11385	COG3162	membrane
DLE02_RS11395	COG3829	transcription factor binding
DLE02_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS11405	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS11425	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS11445	COG2186	Transcriptional regulator
DLE02_RS11455	COG0583	DNA-binding transcription factor activity
DLE02_RS11460	COG4948	Mandelate Racemase Muconate Lactonizing
DLE02_RS11465	COG4829	muconolactone delta-isomerase
DLE02_RS11475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLE02_RS11480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLE02_RS11485	COG0183	Belongs to the thiolase family
DLE02_RS11490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DLE02_RS11500	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS11510	COG3733	amine oxidase
DLE02_RS11520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLE02_RS11530	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS11540	COG4638	Rieske (2fe-2S)
DLE02_RS11560	COG0154	amidase activity
DLE02_RS11570	COG2814	Major facilitator Superfamily
DLE02_RS11595	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS11600	COG0583	DNA-binding transcription factor activity
DLE02_RS11605	COG1414	Transcriptional regulator
DLE02_RS11620	COG2391	methyltransferase activity
DLE02_RS11630	COG4993	Dehydrogenase
DLE02_RS11635	COG3659	wide pore channel activity
DLE02_RS11640	COG3420	alginic acid biosynthetic process
DLE02_RS11645	COG0710	3-dehydroquinate dehydratase activity
DLE02_RS11650	COG3485	protocatechuate 3,4-dioxygenase
DLE02_RS11655	COG3485	protocatechuate 3,4-dioxygenase
DLE02_RS11660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DLE02_RS11665	COG2271	Major facilitator Superfamily
DLE02_RS11670	COG0596	Alpha beta hydrolase
DLE02_RS11675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DLE02_RS11680	COG0183	Belongs to the thiolase family
DLE02_RS11685	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DLE02_RS11690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DLE02_RS11700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DLE02_RS11705	COG2323	membrane
DLE02_RS11750	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLE02_RS11750	COG1902	pentaerythritol trinitrate reductase activity
DLE02_RS11775	COG0542	response to heat
DLE02_RS11780	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DLE02_RS11810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLE02_RS11815	COG0569	domain protein
DLE02_RS11820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DLE02_RS11835	COG4774	siderophore transport
DLE02_RS11840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DLE02_RS11850	COG1585	Membrane protein implicated in regulation of membrane protease activity
DLE02_RS11865	COG1294	oxidase, subunit
DLE02_RS11870	COG4890	Cyd operon protein YbgT
DLE02_RS11885	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DLE02_RS11895	COG0552	protein localization to endoplasmic reticulum
DLE02_RS11920	COG0517	IMP dehydrogenase activity
DLE02_RS11920	COG0516	GMP reductase activity
DLE02_RS11925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLE02_RS11930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DLE02_RS11940	COG0583	DNA-binding transcription factor activity
DLE02_RS11945	COG0024	Methionine aminopeptidase
DLE02_RS11975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DLE02_RS11975	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DLE02_RS11980	COG1105	Belongs to the carbohydrate kinase PfkB family
DLE02_RS11985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLE02_RS11985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DLE02_RS11985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DLE02_RS12005	COG3300	MHYT domain
DLE02_RS12005	COG5001	Diguanylate cyclase
DLE02_RS12020	COG2135	peptidase activity
DLE02_RS12025	COG0659	secondary active sulfate transmembrane transporter activity
DLE02_RS12055	COG1522	sequence-specific DNA binding
DLE02_RS12080	COG1011	Hydrolase
DLE02_RS12085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DLE02_RS12095	COG2137	regulation of response to DNA damage stimulus
DLE02_RS12110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DLE02_RS12145	COG0575	Belongs to the CDS family
DLE02_RS12150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DLE02_RS12170	COG3852	Histidine kinase
DLE02_RS12175	COG2204	response regulator
DLE02_RS12230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DLE02_RS12235	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DLE02_RS12255	COG0697	spore germination
DLE02_RS12260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE02_RS12270	COG0303	'Molybdopterin
DLE02_RS12275	COG0315	cyclic pyranopterin monophosphate synthase activity
DLE02_RS12275	COG0521	Mo-molybdopterin cofactor biosynthetic process
DLE02_RS12290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DLE02_RS12295	COG0243	molybdopterin cofactor binding
DLE02_RS12305	COG0243	molybdopterin cofactor binding
DLE02_RS12310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLE02_RS12315	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLE02_RS12315	COG2146	nitrite reductase [NAD(P)H] activity
DLE02_RS12325	COG0745	RESPONSE REGULATOR receiver
DLE02_RS12330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DLE02_RS12330	COG1116	anion transmembrane transporter activity
DLE02_RS12350	COG0511	ligase activity, forming carbon-carbon bonds
DLE02_RS12365	COG2814	Major facilitator Superfamily
DLE02_RS12470	COG0592	DNA-directed DNA polymerase activity
DLE02_RS12510	COG2026	Addiction module toxin, RelE StbE family
DLE02_RS12700	COG2826	transposase and inactivated derivatives, IS30 family
DLE02_RS12715	COG1484	DNA-dependent DNA replication
DLE02_RS12800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLE02_RS12860	COG0069	glutamate synthase activity
DLE02_RS12880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DLE02_RS12890	COG1454	alcohol dehydrogenase
DLE02_RS12895	COG0824	Thioesterase
DLE02_RS12910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DLE02_RS12925	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DLE02_RS12930	COG2030	dehydratase
DLE02_RS12940	COG0183	Belongs to the thiolase family
DLE02_RS12950	COG0583	DNA-binding transcription factor activity
DLE02_RS12955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DLE02_RS12965	COG1522	sequence-specific DNA binding
DLE02_RS12970	COG3135	benzoate transporter
DLE02_RS12980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DLE02_RS13005	COG0589	response to stress
DLE02_RS13010	COG0488	(ABC) transporter
DLE02_RS13070	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DLE02_RS13075	COG0583	DNA-binding transcription factor activity
DLE02_RS13090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DLE02_RS13135	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DLE02_RS13150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE02_RS13165	COG2814	Major facilitator Superfamily
DLE02_RS13170	COG1024	Enoyl-CoA hydratase
DLE02_RS13175	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS13185	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS13210	COG2186	Transcriptional regulator
DLE02_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS13225	COG4948	Mandelate Racemase Muconate Lactonizing
DLE02_RS13230	COG2271	Major facilitator Superfamily
DLE02_RS13235	COG2721	sulfolactate sulfo-lyase activity
DLE02_RS13240	COG0697	spore germination
DLE02_RS13255	COG1113	amino acid transport
DLE02_RS13275	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS13295	COG0531	amino acid
DLE02_RS13305	COG1113	amino acid transport
DLE02_RS13345	COG3209	COG3209 Rhs family protein
DLE02_RS13375	COG4269	membrane
DLE02_RS13390	COG1902	pentaerythritol trinitrate reductase activity
DLE02_RS13390	COG0446	pyridine nucleotide-disulphide oxidoreductase
DLE02_RS13400	COG2203	Gaf domain
DLE02_RS13400	COG3706	GGDEF domain
DLE02_RS13400	COG4251	negative regulation of phosphorylation
DLE02_RS13400	COG5001	Diguanylate cyclase
DLE02_RS13410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLE02_RS13430	COG4172	Belongs to the ABC transporter superfamily
DLE02_RS13435	COG4239	(ABC) transporter, permease
DLE02_RS13440	COG4174	ABC transporter (Permease)
DLE02_RS13450	COG1388	LysM domain
DLE02_RS13450	COG0741	lytic transglycosylase activity
DLE02_RS13450	COG1388	LysM domain
DLE02_RS13450	COG0741	lytic transglycosylase activity
DLE02_RS13455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLE02_RS13495	COG0583	DNA-binding transcription factor activity
DLE02_RS13500	COG1279	arginine transmembrane transporter activity
DLE02_RS13520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLE02_RS13525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLE02_RS13530	COG0006	proline dipeptidase activity
DLE02_RS13570	COG2194	sulfuric ester hydrolase activity
DLE02_RS13615	COG0739	heme binding
DLE02_RS13755	COG5410	chromosome segregation
DLE02_RS13910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DLE02_RS13950	COG0512	Glutamine amidotransferase of anthranilate synthase
DLE02_RS13955	COG0308	aminopeptidase N
DLE02_RS13985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DLE02_RS13995	COG0302	gtp cyclohydrolase
DLE02_RS14000	COG2826	transposase and inactivated derivatives, IS30 family
DLE02_RS14020	COG3739	integral membrane protein
DLE02_RS14035	COG1169	isochorismate synthase
DLE02_RS14045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DLE02_RS14050	COG1132	(ABC) transporter
DLE02_RS14055	COG1132	(ABC) transporter
DLE02_RS14070	COG1535	isochorismatase
DLE02_RS14070	COG3433	isochorismatase activity
DLE02_RS14080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLE02_RS14090	COG4774	siderophore transport
DLE02_RS14095	COG4607	ABC-type enterochelin transport system periplasmic component
DLE02_RS14100	COG4604	ABC transporter, ATP-binding protein
DLE02_RS14105	COG4605	iron ion homeostasis
DLE02_RS14110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DLE02_RS14120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLE02_RS14135	COG2964	Protein conserved in bacteria
DLE02_RS14145	COG1741	Belongs to the pirin family
DLE02_RS14165	COG1309	transcriptional regulator
DLE02_RS14175	COG4948	Mandelate Racemase Muconate Lactonizing
DLE02_RS14180	COG2814	Major facilitator Superfamily
DLE02_RS14215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DLE02_RS14215	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
DLE02_RS14220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLE02_RS14230	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS14240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLE02_RS14245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLE02_RS14250	COG0583	DNA-binding transcription factor activity
DLE02_RS14255	COG1113	amino acid transport
DLE02_RS14275	COG2508	Transcriptional regulator
DLE02_RS14275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DLE02_RS14310	COG2879	small protein
DLE02_RS14315	COG1966	Carbon starvation protein
DLE02_RS14360	COG1067	ATP-dependent peptidase activity
DLE02_RS14365	COG0583	DNA-binding transcription factor activity
DLE02_RS14390	COG1686	Belongs to the peptidase S11 family
DLE02_RS14395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DLE02_RS14430	COG0616	signal peptide processing
DLE02_RS14435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DLE02_RS14445	COG0573	inorganic phosphate transmembrane transporter activity
DLE02_RS14450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DLE02_RS14455	COG1113	amino acid transport
DLE02_RS14460	COG3961	Belongs to the TPP enzyme family
DLE02_RS14465	COG1522	sequence-specific DNA binding
DLE02_RS14475	COG0076	glutamate decarboxylase activity
DLE02_RS14480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLE02_RS14490	COG1309	transcriptional regulator
DLE02_RS14505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE02_RS14540	COG0352	thiamine-phosphate diphosphorylase activity
DLE02_RS14565	COG0612	Peptidase, M16
DLE02_RS14575	COG1823	symporter activity
DLE02_RS14580	COG0583	DNA-binding transcription factor activity
DLE02_RS14585	COG0477	Major facilitator Superfamily
DLE02_RS14610	COG1187	pseudouridine synthase activity
DLE02_RS14625	COG1686	Belongs to the peptidase S11 family
DLE02_RS14630	COG1252	NADH dehydrogenase
DLE02_RS14640	COG0415	Belongs to the DNA photolyase family
DLE02_RS14655	COG1215	transferase activity, transferring glycosyl groups
DLE02_RS14685	COG2070	2-Nitropropane dioxygenase
DLE02_RS14875	COG5410	chromosome segregation
DLE02_RS15075	COG0556	nucleotide-excision repair
DLE02_RS15095	COG0436	Aminotransferase
DLE02_RS15125	COG4221	oxidoreductase activity
DLE02_RS15135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DLE02_RS15140	COG1381	Involved in DNA repair and RecF pathway recombination
DLE02_RS15150	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DLE02_RS15165	COG0681	Belongs to the peptidase S26 family
DLE02_RS15180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DLE02_RS15200	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DLE02_RS15205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DLE02_RS15210	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DLE02_RS15220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DLE02_RS15225	COG4208	sulfate ABC transporter
DLE02_RS15230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DLE02_RS15235	COG0583	DNA-binding transcription factor activity
DLE02_RS15240	COG4625	pathogenesis
DLE02_RS15255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DLE02_RS15270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DLE02_RS15280	COG1051	belongs to the nudix hydrolase family
DLE02_RS15280	COG1056	cytidyltransferase-related domain
DLE02_RS15285	COG1024	Enoyl-CoA hydratase
DLE02_RS15300	COG2814	Major facilitator Superfamily
DLE02_RS15305	COG0047	phosphoribosylformylglycinamidine synthase activity
DLE02_RS15305	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DLE02_RS15325	COG1473	amidohydrolase
DLE02_RS15330	COG0824	Thioesterase
DLE02_RS15350	COG0823	Involved in the tonB-independent uptake of proteins
DLE02_RS15370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DLE02_RS15405	COG0628	permease
DLE02_RS15415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DLE02_RS15420	COG0596	Alpha beta hydrolase
DLE02_RS15425	COG0616	signal peptide processing
DLE02_RS15425	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DLE02_RS15435	COG2333	competence protein COMEC
DLE02_RS15435	COG0658	competence protein
DLE02_RS15440	COG1136	(ABC) transporter
DLE02_RS15445	COG4591	ABC-type transport system involved in lipoprotein release permease component
DLE02_RS15475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS15495	COG0463	Glycosyl transferase, family 2
DLE02_RS15525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DLE02_RS15530	COG1280	lysine exporter protein (LysE YggA)
DLE02_RS15540	COG0019	diaminopimelate decarboxylase activity
DLE02_RS15550	COG1113	amino acid transport
DLE02_RS15565	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
DLE02_RS15575	COG3339	Conserved Protein
DLE02_RS15580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DLE02_RS15585	COG0243	molybdopterin cofactor binding
DLE02_RS15590	COG1929	Belongs to the glycerate kinase type-1 family
DLE02_RS15605	COG0778	Nitroreductase
DLE02_RS15635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLE02_RS15650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DLE02_RS15670	COG0741	lytic transglycosylase activity
DLE02_RS15690	COG0584	glycerophosphoryl diester phosphodiesterase
DLE02_RS15695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DLE02_RS15720	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DLE02_RS15725	COG1597	lipid kinase activity
DLE02_RS15740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DLE02_RS15745	COG0477	Major facilitator Superfamily
DLE02_RS15795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DLE02_RS15800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DLE02_RS15825	COG0505	Belongs to the CarA family
DLE02_RS15845	COG0589	response to stress
DLE02_RS15860	COG2843	Capsule synthesis protein
DLE02_RS15880	COG2321	neutral zinc metallopeptidase
DLE02_RS15885	COG2354	Protein conserved in bacteria
DLE02_RS15905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DLE02_RS15930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DLE02_RS15935	COG1053	succinate dehydrogenase
DLE02_RS15940	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DLE02_RS15945	COG2009	succinate dehydrogenase
DLE02_RS15985	COG2921	Belongs to the UPF0250 family
DLE02_RS15990	COG0321	lipoyl(octanoyl) transferase activity
DLE02_RS16005	COG0531	amino acid
DLE02_RS16015	COG1733	regulation of RNA biosynthetic process
DLE02_RS16020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DLE02_RS16025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DLE02_RS16025	COG1648	precorrin-2 dehydrogenase activity
DLE02_RS16040	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DLE02_RS16070	COG0671	phosphoesterase, PA-phosphatase related
DLE02_RS16075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS16085	COG1538	Outer membrane efflux protein
DLE02_RS16090	COG0393	Putative heavy-metal-binding
DLE02_RS16095	COG0393	Putative heavy-metal-binding
DLE02_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
DLE02_RS16115	COG0525	valine-tRNA ligase activity
DLE02_RS16135	COG0583	DNA-binding transcription factor activity
DLE02_RS16140	COG0004	ammonium transporteR
DLE02_RS16150	COG0642	Histidine kinase
DLE02_RS16155	COG0745	RESPONSE REGULATOR receiver
DLE02_RS16160	COG2194	sulfuric ester hydrolase activity
DLE02_RS16180	COG1752	Esterase of the alpha-beta hydrolase superfamily
DLE02_RS16195	COG2315	Protein conserved in bacteria
DLE02_RS16200	COG0142	geranyltranstransferase activity
DLE02_RS16205	COG2828	Protein conserved in bacteria
DLE02_RS16210	COG1113	amino acid transport
DLE02_RS16230	COG2207	Transcriptional regulator
DLE02_RS16255	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLE02_RS16265	COG0560	Phosphoserine phosphatase
DLE02_RS16275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DLE02_RS16285	COG1530	ribonuclease E activity
DLE02_RS16290	COG0424	maF-like protein
DLE02_RS16295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DLE02_RS16300	COG1792	Involved in formation and maintenance of cell shape
DLE02_RS16305	COG1077	Cell shape determining protein MreB Mrl
DLE02_RS16310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE02_RS16320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DLE02_RS16350	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DLE02_RS16355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DLE02_RS16360	COG1752	Esterase of the alpha-beta hydrolase superfamily
DLE02_RS16365	COG1115	amino acid carrier protein
DLE02_RS16385	COG2814	Major facilitator Superfamily
DLE02_RS16390	COG1289	transmembrane transporter activity
DLE02_RS16400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DLE02_RS16440	COG1376	ErfK ybiS ycfS ynhG family protein
DLE02_RS16445	COG2832	Protein of unknown function (DUF454)
DLE02_RS16455	COG5510	response to toxic substance
DLE02_RS16475	COG0840	transmembrane signaling receptor activity
DLE02_RS16515	COG3422	double-strand break repair
DLE02_RS16520	COG2824	Alkylphosphonate utilization operon protein PhnA
DLE02_RS16525	COG3189	MarR family transcriptional regulator
DLE02_RS16535	COG0354	folic acid binding
DLE02_RS16540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DLE02_RS16550	COG0679	Auxin Efflux Carrier
DLE02_RS16555	COG1902	pentaerythritol trinitrate reductase activity
DLE02_RS16560	COG4772	TonB-dependent receptor
DLE02_RS16565	COG2094	Belongs to the DNA glycosylase MPG family
DLE02_RS16590	COG1217	gtp-binding protein TYPA
DLE02_RS16595	COG2233	PERMEase
DLE02_RS16605	COG0833	amino acid
DLE02_RS16610	COG1690	Belongs to the RtcB family
DLE02_RS16620	COG2885	chlorophyll binding
DLE02_RS16620	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DLE02_RS16630	COG0183	Belongs to the thiolase family
DLE02_RS16650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DLE02_RS16670	COG2207	Transcriptional regulator
DLE02_RS16675	COG0183	Belongs to the thiolase family
DLE02_RS16705	COG1272	protein, Hemolysin III
DLE02_RS16710	COG0477	Major facilitator Superfamily
DLE02_RS16725	COG0450	alkyl hydroperoxide reductase
DLE02_RS16745	COG0285	dihydrofolate synthase activity
DLE02_RS16795	COG2096	Adenosyltransferase
DLE02_RS16815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DLE02_RS16820	COG0745	RESPONSE REGULATOR receiver
DLE02_RS16825	COG2205	protein histidine kinase activity
DLE02_RS16835	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS16840	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS16885	COG0438	transferase activity, transferring glycosyl groups
DLE02_RS16890	COG1215	transferase activity, transferring glycosyl groups
DLE02_RS16895	COG0438	transferase activity, transferring glycosyl groups
DLE02_RS16915	COG0438	transferase activity, transferring glycosyl groups
DLE02_RS16920	COG0726	polysaccharide deacetylase
DLE02_RS16935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DLE02_RS16940	COG2205	protein histidine kinase activity
DLE02_RS16990	COG1862	Preprotein translocase
DLE02_RS17000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DLE02_RS17005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DLE02_RS17015	COG3781	membrane
DLE02_RS17020	COG0613	PHP domain protein
DLE02_RS17030	COG2350	Protein conserved in bacteria
DLE02_RS17060	COG1607	acyl-coa hydrolase
DLE02_RS17120	COG2199	diguanylate cyclase activity
DLE02_RS17130	COG1408	metallophosphoesterase
DLE02_RS17135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DLE02_RS17145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DLE02_RS17165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DLE02_RS17170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DLE02_RS17185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DLE02_RS17195	COG2969	positive regulation of protein catabolic process
DLE02_RS17215	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS17220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DLE02_RS17235	COG1309	transcriptional regulator
DLE02_RS17240	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS17285	COG1183	phosphatidylcholine synthase activity
DLE02_RS17290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DLE02_RS17320	COG0739	heme binding
DLE02_RS17320	COG0741	lytic transglycosylase activity
DLE02_RS17320	COG1196	nuclear chromosome segregation
DLE02_RS17330	COG1702	phosphate starvation-inducible protein PhoH
DLE02_RS17365	COG1295	ribonuclease BN
DLE02_RS17370	COG0697	spore germination
DLE02_RS17375	COG2169	Transcriptional regulator
DLE02_RS17380	COG0179	Fumarylacetoacetate (FAA) hydrolase
DLE02_RS17425	COG0557	exoribonuclease II activity
DLE02_RS17430	COG0339	signal peptide processing
DLE02_RS17435	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
DLE02_RS17465	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DLE02_RS17470	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS17625	COG0626	cystathionine gamma-synthase activity
DLE02_RS17630	COG0433	COG0433 Predicted ATPase
DLE02_RS17635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DLE02_RS17635	COG1017	nitric oxide dioxygenase activity
DLE02_RS17640	COG1959	2 iron, 2 sulfur cluster binding
DLE02_RS17655	COG1301	dicarboxylic acid transport
DLE02_RS17660	COG1946	Acyl-CoA thioesterase
DLE02_RS17680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DLE02_RS17685	COG1040	competence protein
DLE02_RS17690	COG0494	nUDIX hydrolase
DLE02_RS17700	COG0598	Magnesium transport protein CorA
DLE02_RS17710	COG2854	intermembrane phospholipid transfer
DLE02_RS17720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DLE02_RS17725	COG1127	ABC transporter
DLE02_RS17735	COG0513	Belongs to the DEAD box helicase family
DLE02_RS17755	COG0408	coproporphyrinogen oxidase activity
DLE02_RS17770	COG1960	acyl-CoA dehydrogenase activity
DLE02_RS17780	COG1983	PspC domain protein
DLE02_RS17785	COG0517	IMP dehydrogenase activity
DLE02_RS17830	COG0583	DNA-binding transcription factor activity
DLE02_RS17870	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS17880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DLE02_RS17885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DLE02_RS17890	COG0833	amino acid
DLE02_RS17920	COG1192	Involved in chromosome partitioning
DLE02_RS17925	COG0628	permease
DLE02_RS17935	COG1289	transmembrane transporter activity
DLE02_RS17950	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLE02_RS17955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DLE02_RS17965	COG0277	FAD linked oxidase domain protein
DLE02_RS17970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DLE02_RS17995	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DLE02_RS18000	COG5380	lipid catabolic process
DLE02_RS18020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DLE02_RS18070	COG0194	GDP metabolic process
DLE02_RS18085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DLE02_RS18105	COG3307	-O-antigen
DLE02_RS18120	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DLE02_RS18125	COG1704	LemA family
DLE02_RS18135	COG0493	'glutamate synthase
DLE02_RS18140	COG0069	glutamate synthase activity
DLE02_RS18140	COG0070	glutamate synthase
DLE02_RS18140	COG0067	glutamate synthase
DLE02_RS18190	COG2226	methyltransferase
DLE02_RS18205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DLE02_RS18210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DLE02_RS18255	COG0833	amino acid
DLE02_RS18320	COG0488	(ABC) transporter
DLE02_RS18325	COG2873	o-acetylhomoserine
DLE02_RS18330	COG4221	oxidoreductase activity
DLE02_RS18335	COG0659	secondary active sulfate transmembrane transporter activity
DLE02_RS18360	COG0427	acetyl-CoA hydrolase
DLE02_RS18390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DLE02_RS18430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DLE02_RS18485	COG2207	Transcriptional regulator
DLE02_RS18490	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DLE02_RS18505	COG2249	NAD(P)H dehydrogenase (quinone) activity
DLE02_RS18510	COG1733	regulation of RNA biosynthetic process
DLE02_RS18525	COG1733	regulation of RNA biosynthetic process
DLE02_RS18545	COG0667	Aldo Keto reductase
DLE02_RS18570	COG0583	DNA-binding transcription factor activity
DLE02_RS18575	COG2814	Major facilitator Superfamily
DLE02_RS18605	COG1335	isochorismatase
DLE02_RS18615	COG1012	belongs to the aldehyde dehydrogenase family
DLE02_RS18620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DLE02_RS18630	COG1113	amino acid transport
DLE02_RS18640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DLE02_RS18655	COG2814	Major facilitator Superfamily
DLE02_RS18665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DLE02_RS18665	COG0352	thiamine-phosphate diphosphorylase activity
DLE02_RS18665	COG0351	phosphomethylpyrimidine kinase
DLE02_RS18685	COG1309	transcriptional regulator
DLE02_RS18690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DLE02_RS18705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DLE02_RS18715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DLE02_RS18720	COG3162	membrane
DLE02_RS18725	COG2198	Histidine kinase
DLE02_RS18725	COG2205	protein histidine kinase activity
DLE02_RS18725	COG0784	Response regulator, receiver
DLE02_RS18750	COG1522	sequence-specific DNA binding
DLE02_RS18755	COG1335	isochorismatase
DLE02_RS18760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DLE02_RS18770	COG0668	transmembrane transport
DLE02_RS18775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DLE02_RS18780	COG1519	Transferase
DLE02_RS18785	COG1902	pentaerythritol trinitrate reductase activity
DLE02_RS18805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DLE02_RS18830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DLE02_RS18830	COG0426	domain, Protein
DLE02_RS18835	COG4774	siderophore transport
DLE02_RS18840	COG2119	membrane
DLE02_RS18850	COG0508	dehydrogenase complex catalyzes the overall conversion of
DLE02_RS18860	COG4942	peptidase
DLE02_RS18875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DLE02_RS18885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DLE02_RS18905	COG0189	ligase activity
DLE02_RS18925	COG0708	Exodeoxyribonuclease III
DLE02_RS18930	COG1393	Belongs to the ArsC family
DLE02_RS18985	COG2233	PERMEase
DLE02_RS18995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DLE02_RS19005	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DLE02_RS19015	COG3150	esterase
DLE02_RS19040	COG3179	chitinase
DLE02_RS19055	COG2918	glutathione biosynthetic process
DLE02_RS19070	COG2733	membrane
DLE02_RS19075	COG0436	Aminotransferase
DLE02_RS19080	COG0534	Mate efflux family protein
DLE02_RS19140	COG0753	catalase activity
DLE02_RS19185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DLE02_RS19190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DLE02_RS19200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DLE02_RS19205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DLE02_RS19210	COG0546	phosphoglycolate phosphatase activity
DLE02_RS19220	COG0010	Belongs to the arginase family
DLE02_RS19250	COG2188	Transcriptional regulator
DLE02_RS19260	COG0523	cobalamin synthesis protein
DLE02_RS19270	COG1113	amino acid transport
DLE02_RS19280	COG0625	glutathione transferase activity
DLE02_RS19300	COG1683	Conserved Protein
DLE02_RS19305	COG0534	Mate efflux family protein
DLE02_RS19310	COG0385	Bile acid
DLE02_RS19315	COG1335	isochorismatase
DLE02_RS19320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DLE02_RS19340	COG2116	formate transmembrane transporter activity
DLE02_RS19345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DLE02_RS19350	COG2133	pyrroloquinoline quinone binding
DLE02_RS19355	COG2983	Belongs to the UPF0260 family
DLE02_RS19375	COG1194	a g-specific adenine glycosylase
DLE02_RS19390	COG2818	Glycosylase
DLE02_RS19395	COG1064	alcohol dehydrogenase
DLE02_RS19400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DLE02_RS19415	COG0583	DNA-binding transcription factor activity
DLE02_RS19420	COG0656	L-ascorbic acid biosynthetic process
DLE02_RS19425	COG2814	Major facilitator Superfamily
DLE02_RS19460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DLE02_RS19475	COG2233	PERMEase
DLE02_RS19515	COG0733	neurotransmitter:sodium symporter activity
DLE02_RS19575	COG0358	DNA primase activity
DLE02_RS19615	COG0194	GDP metabolic process
DLE02_RS19640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DLE02_RS19695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DLE02_RS19740	COG0419	ATPase involved in DNA repair
DLE02_RS19765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLE02_RS19765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DLE02_RS19770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DLE02_RS19795	COG0756	dUTP diphosphatase activity
DLE02_RS20010	COG1475	DNA binding
DLE02_RS20015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DLE02_RS20125	COG0791	NLP P60 protein