locus-tag	class	description
HB365_RS00010	COG0592	DNA-directed DNA polymerase activity
HB365_RS00020	COG0187	DNA topoisomerase II activity
HB365_RS00030	COG0586	Pfam SNARE associated Golgi protein
HB365_RS00035	COG0488	(ABC) transporter
HB365_RS00060	COG0596	Alpha beta hydrolase
HB365_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB365_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB365_RS00110	COG0733	neurotransmitter:sodium symporter activity
HB365_RS00150	COG2233	PERMEase
HB365_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS00200	COG2814	Major facilitator Superfamily
HB365_RS00205	COG0656	L-ascorbic acid biosynthetic process
HB365_RS00210	COG0583	DNA-binding transcription factor activity
HB365_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB365_RS00230	COG1064	alcohol dehydrogenase
HB365_RS00235	COG2818	Glycosylase
HB365_RS00250	COG1194	a g-specific adenine glycosylase
HB365_RS00270	COG2983	Belongs to the UPF0260 family
HB365_RS00275	COG2133	pyrroloquinoline quinone binding
HB365_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB365_RS00285	COG2116	formate transmembrane transporter activity
HB365_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB365_RS00310	COG1335	isochorismatase
HB365_RS00315	COG0385	Bile acid
HB365_RS00320	COG0534	Mate efflux family protein
HB365_RS00325	COG1683	Conserved Protein
HB365_RS00345	COG0625	glutathione transferase activity
HB365_RS00355	COG1113	amino acid transport
HB365_RS00365	COG0523	cobalamin synthesis protein
HB365_RS00375	COG2188	Transcriptional regulator
HB365_RS00405	COG0010	Belongs to the arginase family
HB365_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB365_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB365_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB365_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB365_RS00540	COG0534	Mate efflux family protein
HB365_RS00545	COG0436	Aminotransferase
HB365_RS00550	COG2733	membrane
HB365_RS00565	COG2918	glutathione biosynthetic process
HB365_RS00575	COG3501	Rhs element vgr protein
HB365_RS00580	COG1388	LysM domain
HB365_RS00580	COG0791	NLP P60 protein
HB365_RS00595	COG3150	esterase
HB365_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB365_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB365_RS00630	COG2233	PERMEase
HB365_RS00635	COG2351	hydroxyisourate hydrolase activity
HB365_RS00670	COG3706	GGDEF domain
HB365_RS00685	COG1393	Belongs to the ArsC family
HB365_RS00690	COG0708	Exodeoxyribonuclease III
HB365_RS00710	COG0189	ligase activity
HB365_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB365_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB365_RS00755	COG4942	peptidase
HB365_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB365_RS00775	COG2119	membrane
HB365_RS00780	COG4774	siderophore transport
HB365_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB365_RS00785	COG0426	domain, Protein
HB365_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB365_RS00830	COG1902	pentaerythritol trinitrate reductase activity
HB365_RS00835	COG1519	Transferase
HB365_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB365_RS00845	COG0668	transmembrane transport
HB365_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB365_RS00860	COG1335	isochorismatase
HB365_RS00865	COG1522	sequence-specific DNA binding
HB365_RS00870	COG3328	transposase activity
HB365_RS00895	COG0784	Response regulator, receiver
HB365_RS00895	COG2198	Histidine kinase
HB365_RS00895	COG2205	protein histidine kinase activity
HB365_RS00900	COG3162	membrane
HB365_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB365_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB365_RS00925	COG3706	GGDEF domain
HB365_RS00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB365_RS00940	COG1309	transcriptional regulator
HB365_RS00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB365_RS00960	COG0352	thiamine-phosphate diphosphorylase activity
HB365_RS00960	COG0351	phosphomethylpyrimidine kinase
HB365_RS00970	COG2814	Major facilitator Superfamily
HB365_RS00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB365_RS00995	COG1113	amino acid transport
HB365_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB365_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS01020	COG1335	isochorismatase
HB365_RS01050	COG2814	Major facilitator Superfamily
HB365_RS01055	COG0583	DNA-binding transcription factor activity
HB365_RS01075	COG0667	Aldo Keto reductase
HB365_RS01105	COG1733	regulation of RNA biosynthetic process
HB365_RS01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB365_RS01175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB365_RS01190	COG2329	Antibiotic biosynthesis monooxygenase
HB365_RS01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB365_RS01250	COG0427	acetyl-CoA hydrolase
HB365_RS01265	COG0745	RESPONSE REGULATOR receiver
HB365_RS01275	COG0659	secondary active sulfate transmembrane transporter activity
HB365_RS01280	COG4221	oxidoreductase activity
HB365_RS01285	COG2873	o-acetylhomoserine
HB365_RS01290	COG0488	(ABC) transporter
HB365_RS01370	COG0833	amino acid
HB365_RS01415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB365_RS01420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB365_RS01435	COG2226	methyltransferase
HB365_RS01485	COG0067	glutamate synthase
HB365_RS01485	COG0070	glutamate synthase
HB365_RS01485	COG0069	glutamate synthase activity
HB365_RS01490	COG0493	'glutamate synthase
HB365_RS01500	COG1704	LemA family
HB365_RS01505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB365_RS01525	COG3307	-O-antigen
HB365_RS01545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB365_RS01560	COG0194	GDP metabolic process
HB365_RS01610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB365_RS01630	COG5380	lipid catabolic process
HB365_RS01635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB365_RS01660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB365_RS01665	COG0277	FAD linked oxidase domain protein
HB365_RS01685	COG1061	Type III restriction enzyme res subunit
HB365_RS01705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB365_RS01710	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB365_RS01725	COG1289	transmembrane transporter activity
HB365_RS01735	COG0628	permease
HB365_RS01740	COG1192	Involved in chromosome partitioning
HB365_RS01770	COG0833	amino acid
HB365_RS01775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB365_RS01780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB365_RS01790	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS01830	COG0583	DNA-binding transcription factor activity
HB365_RS01875	COG0517	IMP dehydrogenase activity
HB365_RS01880	COG1983	PspC domain protein
HB365_RS01890	COG1960	acyl-CoA dehydrogenase activity
HB365_RS01905	COG0408	coproporphyrinogen oxidase activity
HB365_RS01925	COG0513	Belongs to the DEAD box helicase family
HB365_RS01935	COG1127	ABC transporter
HB365_RS01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB365_RS01950	COG2854	intermembrane phospholipid transfer
HB365_RS01960	COG0598	Magnesium transport protein CorA
HB365_RS01970	COG0494	nUDIX hydrolase
HB365_RS01975	COG1040	competence protein
HB365_RS01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB365_RS02000	COG1946	Acyl-CoA thioesterase
HB365_RS02005	COG1301	dicarboxylic acid transport
HB365_RS02020	COG1959	2 iron, 2 sulfur cluster binding
HB365_RS02025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB365_RS02025	COG1017	nitric oxide dioxygenase activity
HB365_RS02030	COG0433	COG0433 Predicted ATPase
HB365_RS02035	COG0626	cystathionine gamma-synthase activity
HB365_RS02190	COG1960	acyl-CoA dehydrogenase activity
HB365_RS02195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB365_RS02225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB365_RS02230	COG0339	signal peptide processing
HB365_RS02235	COG0557	exoribonuclease II activity
HB365_RS02280	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB365_RS02285	COG2169	Transcriptional regulator
HB365_RS02290	COG0697	spore germination
HB365_RS02295	COG1295	ribonuclease BN
HB365_RS02330	COG1702	phosphate starvation-inducible protein PhoH
HB365_RS02340	COG0739	heme binding
HB365_RS02340	COG1196	nuclear chromosome segregation
HB365_RS02340	COG0741	lytic transglycosylase activity
HB365_RS02370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB365_RS02375	COG1183	phosphatidylcholine synthase activity
HB365_RS02420	COG1960	acyl-CoA dehydrogenase activity
HB365_RS02425	COG1309	transcriptional regulator
HB365_RS02440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB365_RS02445	COG1960	acyl-CoA dehydrogenase activity
HB365_RS02465	COG2969	positive regulation of protein catabolic process
HB365_RS02475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB365_RS02490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB365_RS02495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB365_RS02515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB365_RS02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB365_RS02530	COG1408	metallophosphoesterase
HB365_RS02540	COG2199	diguanylate cyclase activity
HB365_RS02600	COG1607	acyl-coa hydrolase
HB365_RS02630	COG2350	Protein conserved in bacteria
HB365_RS02640	COG0613	PHP domain protein
HB365_RS02645	COG3781	membrane
HB365_RS02655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB365_RS02660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB365_RS02670	COG1862	Preprotein translocase
HB365_RS02700	COG2205	protein histidine kinase activity
HB365_RS02705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB365_RS02725	COG0726	polysaccharide deacetylase
HB365_RS02730	COG0463	Glycosyl transferase, family 2
HB365_RS02810	COG0625	glutathione transferase activity
HB365_RS02815	COG0583	DNA-binding transcription factor activity
HB365_RS02820	COG1960	acyl-CoA dehydrogenase activity
HB365_RS02825	COG1960	acyl-CoA dehydrogenase activity
HB365_RS02835	COG2205	protein histidine kinase activity
HB365_RS02840	COG0745	RESPONSE REGULATOR receiver
HB365_RS02845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB365_RS02865	COG2096	Adenosyltransferase
HB365_RS02915	COG0285	dihydrofolate synthase activity
HB365_RS02935	COG0450	alkyl hydroperoxide reductase
HB365_RS02950	COG0477	Major facilitator Superfamily
HB365_RS02955	COG1272	protein, Hemolysin III
HB365_RS02990	COG0183	Belongs to the thiolase family
HB365_RS02995	COG2207	Transcriptional regulator
HB365_RS03015	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB365_RS03035	COG0183	Belongs to the thiolase family
HB365_RS03045	COG2885	chlorophyll binding
HB365_RS03045	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB365_RS03055	COG1690	Belongs to the RtcB family
HB365_RS03060	COG0833	amino acid
HB365_RS03070	COG2233	PERMEase
HB365_RS03100	COG2094	Belongs to the DNA glycosylase MPG family
HB365_RS03105	COG4772	TonB-dependent receptor
HB365_RS03120	COG1902	pentaerythritol trinitrate reductase activity
HB365_RS03125	COG0679	Auxin Efflux Carrier
HB365_RS03135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB365_RS03140	COG0354	folic acid binding
HB365_RS03150	COG3189	MarR family transcriptional regulator
HB365_RS03155	COG2824	Alkylphosphonate utilization operon protein PhnA
HB365_RS03160	COG3422	double-strand break repair
HB365_RS03200	COG0840	transmembrane signaling receptor activity
HB365_RS03220	COG5510	response to toxic substance
HB365_RS03230	COG2832	Protein of unknown function (DUF454)
HB365_RS03235	COG1376	ErfK ybiS ycfS ynhG family protein
HB365_RS03275	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB365_RS03285	COG1289	transmembrane transporter activity
HB365_RS03290	COG2814	Major facilitator Superfamily
HB365_RS03310	COG1115	amino acid carrier protein
HB365_RS03315	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB365_RS03320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB365_RS03325	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB365_RS03365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB365_RS03375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB365_RS03380	COG1077	Cell shape determining protein MreB Mrl
HB365_RS03385	COG1792	Involved in formation and maintenance of cell shape
HB365_RS03390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB365_RS03395	COG0424	maF-like protein
HB365_RS03400	COG1530	ribonuclease E activity
HB365_RS03410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB365_RS03420	COG0560	Phosphoserine phosphatase
HB365_RS03430	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB365_RS03455	COG2207	Transcriptional regulator
HB365_RS03475	COG1113	amino acid transport
HB365_RS03480	COG2828	Protein conserved in bacteria
HB365_RS03485	COG0142	geranyltranstransferase activity
HB365_RS03490	COG2315	Protein conserved in bacteria
HB365_RS03505	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB365_RS03525	COG2194	sulfuric ester hydrolase activity
HB365_RS03530	COG0745	RESPONSE REGULATOR receiver
HB365_RS03535	COG0642	Histidine kinase
HB365_RS03545	COG0004	ammonium transporteR
HB365_RS03550	COG0583	DNA-binding transcription factor activity
HB365_RS03570	COG0525	valine-tRNA ligase activity
HB365_RS03580	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS03590	COG0393	Putative heavy-metal-binding
HB365_RS03595	COG0393	Putative heavy-metal-binding
HB365_RS03600	COG1538	Outer membrane efflux protein
HB365_RS03610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS03615	COG0671	phosphoesterase, PA-phosphatase related
HB365_RS03645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB365_RS03660	COG1648	precorrin-2 dehydrogenase activity
HB365_RS03660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB365_RS03665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB365_RS03670	COG1733	regulation of RNA biosynthetic process
HB365_RS03680	COG0531	amino acid
HB365_RS03695	COG0321	lipoyl(octanoyl) transferase activity
HB365_RS03700	COG2921	Belongs to the UPF0250 family
HB365_RS03740	COG2009	succinate dehydrogenase
HB365_RS03745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB365_RS03750	COG1053	succinate dehydrogenase
HB365_RS03755	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB365_RS03780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB365_RS03800	COG2354	Protein conserved in bacteria
HB365_RS03805	COG2321	neutral zinc metallopeptidase
HB365_RS03840	COG2843	Capsule synthesis protein
HB365_RS03855	COG0589	response to stress
HB365_RS03875	COG0505	Belongs to the CarA family
HB365_RS03900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB365_RS03905	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB365_RS03955	COG0477	Major facilitator Superfamily
HB365_RS03960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB365_RS03975	COG1597	lipid kinase activity
HB365_RS03980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB365_RS04010	COG0584	glycerophosphoryl diester phosphodiesterase
HB365_RS04030	COG0741	lytic transglycosylase activity
HB365_RS04050	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB365_RS04065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB365_RS04090	COG0778	Nitroreductase
HB365_RS04105	COG1929	Belongs to the glycerate kinase type-1 family
HB365_RS04110	COG0243	molybdopterin cofactor binding
HB365_RS04115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB365_RS04120	COG3339	Conserved Protein
HB365_RS04130	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB365_RS04145	COG1113	amino acid transport
HB365_RS04155	COG0019	diaminopimelate decarboxylase activity
HB365_RS04165	COG1280	lysine exporter protein (LysE YggA)
HB365_RS04170	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB365_RS04200	COG0463	Glycosyl transferase, family 2
HB365_RS04220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS04255	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB365_RS04260	COG1136	(ABC) transporter
HB365_RS04265	COG0658	competence protein
HB365_RS04265	COG2333	competence protein COMEC
HB365_RS04275	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB365_RS04275	COG0616	signal peptide processing
HB365_RS04280	COG0596	Alpha beta hydrolase
HB365_RS04285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB365_RS04295	COG0628	permease
HB365_RS04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB365_RS04350	COG0823	Involved in the tonB-independent uptake of proteins
HB365_RS04370	COG0824	Thioesterase
HB365_RS04375	COG1473	amidohydrolase
HB365_RS04395	COG0047	phosphoribosylformylglycinamidine synthase activity
HB365_RS04395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB365_RS04400	COG2814	Major facilitator Superfamily
HB365_RS04410	COG1024	Enoyl-CoA hydratase
HB365_RS04415	COG1051	belongs to the nudix hydrolase family
HB365_RS04415	COG1056	cytidyltransferase-related domain
HB365_RS04425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB365_RS04440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB365_RS04455	COG4625	pathogenesis
HB365_RS04460	COG0583	DNA-binding transcription factor activity
HB365_RS04465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB365_RS04470	COG4208	sulfate ABC transporter
HB365_RS04475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB365_RS04485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB365_RS04490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB365_RS04495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB365_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB365_RS04530	COG0681	Belongs to the peptidase S26 family
HB365_RS04545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB365_RS04555	COG1381	Involved in DNA repair and RecF pathway recombination
HB365_RS04560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB365_RS04570	COG4221	oxidoreductase activity
HB365_RS04600	COG0436	Aminotransferase
HB365_RS04620	COG0556	nucleotide-excision repair
HB365_RS04675	COG2070	2-Nitropropane dioxygenase
HB365_RS04705	COG1215	transferase activity, transferring glycosyl groups
HB365_RS04720	COG0415	Belongs to the DNA photolyase family
HB365_RS04730	COG1252	NADH dehydrogenase
HB365_RS04735	COG1686	Belongs to the peptidase S11 family
HB365_RS04750	COG1187	pseudouridine synthase activity
HB365_RS04775	COG0477	Major facilitator Superfamily
HB365_RS04780	COG0583	DNA-binding transcription factor activity
HB365_RS04795	COG0612	Peptidase, M16
HB365_RS04820	COG0352	thiamine-phosphate diphosphorylase activity
HB365_RS04855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB365_RS04870	COG1309	transcriptional regulator
HB365_RS04880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB365_RS04885	COG0076	glutamate decarboxylase activity
HB365_RS04895	COG1522	sequence-specific DNA binding
HB365_RS04900	COG3961	Belongs to the TPP enzyme family
HB365_RS04905	COG1113	amino acid transport
HB365_RS04910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB365_RS04915	COG0573	inorganic phosphate transmembrane transporter activity
HB365_RS04925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB365_RS04930	COG0616	signal peptide processing
HB365_RS04940	COG3328	transposase activity
HB365_RS04970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB365_RS04975	COG1686	Belongs to the peptidase S11 family
HB365_RS05000	COG0583	DNA-binding transcription factor activity
HB365_RS05005	COG1067	ATP-dependent peptidase activity
HB365_RS05050	COG1966	Carbon starvation protein
HB365_RS05055	COG2879	small protein
HB365_RS05095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HB365_RS05095	COG2508	Transcriptional regulator
HB365_RS05115	COG1113	amino acid transport
HB365_RS05120	COG0583	DNA-binding transcription factor activity
HB365_RS05125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB365_RS05130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB365_RS05140	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS05145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB365_RS05150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB365_RS05150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB365_RS05185	COG2814	Major facilitator Superfamily
HB365_RS05190	COG4948	Mandelate Racemase Muconate Lactonizing
HB365_RS05200	COG1309	transcriptional regulator
HB365_RS05220	COG1741	Belongs to the pirin family
HB365_RS05230	COG2964	Protein conserved in bacteria
HB365_RS05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB365_RS05250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB365_RS05255	COG4605	iron ion homeostasis
HB365_RS05260	COG4604	ABC transporter, ATP-binding protein
HB365_RS05265	COG4607	ABC-type enterochelin transport system periplasmic component
HB365_RS05270	COG4774	siderophore transport
HB365_RS05280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB365_RS05285	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB365_RS05290	COG1535	isochorismatase
HB365_RS05290	COG3433	isochorismatase activity
HB365_RS05305	COG1132	(ABC) transporter
HB365_RS05315	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB365_RS05325	COG1169	isochorismate synthase
HB365_RS05340	COG3739	integral membrane protein
HB365_RS05375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB365_RS05405	COG0308	aminopeptidase N
HB365_RS05410	COG0512	Glutamine amidotransferase of anthranilate synthase
HB365_RS05420	COG3104	oligopeptide transport
HB365_RS05425	COG0174	glutamine synthetase
HB365_RS05435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB365_RS05470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB365_RS05475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB365_RS05480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB365_RS05500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB365_RS05505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB365_RS05510	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB365_RS05525	COG1960	acyl-CoA dehydrogenase activity
HB365_RS05530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB365_RS05535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB365_RS05545	COG2223	nitrite transmembrane transporter activity
HB365_RS05555	COG0024	Methionine aminopeptidase
HB365_RS05560	COG0052	Belongs to the universal ribosomal protein uS2 family
HB365_RS05575	COG2207	Transcriptional regulator
HB365_RS05600	COG2951	lytic endotransglycosylase activity
HB365_RS05605	COG0772	Belongs to the SEDS family
HB365_RS05620	COG0842	Transport permease protein
HB365_RS05625	COG1131	(ABC) transporter
HB365_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS05685	COG4215	(ABC) transporter
HB365_RS05690	COG4160	amino acid transport
HB365_RS05695	COG4598	ABC transporter
HB365_RS05705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB365_RS05715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB365_RS05730	COG1720	tRNA m6t6A37 methyltransferase activity
HB365_RS05750	COG0745	RESPONSE REGULATOR receiver
HB365_RS05755	COG0642	Histidine kinase
HB365_RS05765	COG0494	nUDIX hydrolase
HB365_RS05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB365_RS05780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB365_RS05785	COG3139	Protein of unknown function (DUF1315)
HB365_RS05790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB365_RS05795	COG1301	dicarboxylic acid transport
HB365_RS05800	COG1960	acyl-CoA dehydrogenase activity
HB365_RS05805	COG2819	hydrolase of the alpha beta superfamily
HB365_RS05815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB365_RS05825	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB365_RS05830	COG1234	tRNA 3'-trailer cleavage
HB365_RS05860	COG2363	Small membrane protein
HB365_RS05880	COG0513	Belongs to the DEAD box helicase family
HB365_RS05890	COG0778	Nitroreductase
HB365_RS05920	COG1286	toxin biosynthetic process
HB365_RS05945	COG4783	chaperone-mediated protein folding
HB365_RS05950	COG1610	YqeY-like protein
HB365_RS06050	COG3111	PFAM Bacterial OB fold (BOF) protein
HB365_RS06075	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB365_RS06080	COG0786	glutamate:sodium symporter activity
HB365_RS06090	COG2186	Transcriptional regulator
HB365_RS06140	COG0477	Major facilitator Superfamily
HB365_RS06165	COG2985	domain, Protein
HB365_RS06175	COG2995	paraquat-inducible protein a
HB365_RS06180	COG3008	intermembrane lipid transfer
HB365_RS06180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB365_RS06200	COG0482	sulfurtransferase activity
HB365_RS06220	COG3173	Aminoglycoside phosphotransferase
HB365_RS06230	COG2433	Pfam Transposase IS66
HB365_RS06270	COG1301	dicarboxylic acid transport
HB365_RS06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB365_RS06285	COG2011	ABC-type metal ion transport system permease component
HB365_RS06290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB365_RS06295	COG1464	Belongs to the NlpA lipoprotein family
HB365_RS06300	COG0151	Belongs to the GarS family
HB365_RS06305	COG0138	bifunctional purine biosynthesis protein purh
HB365_RS06310	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB365_RS06340	COG2308	Evidence 4 Homologs of previously reported genes of
HB365_RS06350	COG1305	Transglutaminase-like
HB365_RS06360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB365_RS06365	COG0305	Participates in initiation and elongation during chromosome replication
HB365_RS06390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB365_RS06400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB365_RS06405	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB365_RS06430	COG0726	polysaccharide deacetylase
HB365_RS06430	COG1649	PFAM Uncharacterised BCR, COG1649
HB365_RS06435	COG1215	transferase activity, transferring glycosyl groups
HB365_RS06440	COG3658	cytochrome
HB365_RS06450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB365_RS06465	COG0583	DNA-binding transcription factor activity
HB365_RS06485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB365_RS06490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB365_RS06505	COG1960	acyl-CoA dehydrogenase activity
HB365_RS06510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB365_RS06515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB365_RS06540	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB365_RS06545	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB365_RS06555	COG2205	protein histidine kinase activity
HB365_RS06560	COG0745	RESPONSE REGULATOR receiver
HB365_RS06565	COG0174	glutamine synthetase
HB365_RS06585	COG0729	surface antigen
HB365_RS06610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB365_RS06615	COG2814	Major facilitator Superfamily
HB365_RS06630	COG0583	DNA-binding transcription factor activity
HB365_RS06645	COG1187	pseudouridine synthase activity
HB365_RS06665	COG0802	atpase or kinase
HB365_RS06670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB365_RS06680	COG1923	regulation of RNA biosynthetic process
HB365_RS06685	COG0697	spore germination
HB365_RS06700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB365_RS06710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB365_RS06715	COG0519	Catalyzes the synthesis of GMP from XMP
HB365_RS06715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB365_RS06720	COG4302	ethanolamine ammonia-lyase activity
HB365_RS06725	COG4303	Ethanolamine ammonia lyase large subunit
HB365_RS06730	COG0531	amino acid
HB365_RS06750	COG1454	alcohol dehydrogenase
HB365_RS06755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB365_RS06765	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HB365_RS06785	COG0308	aminopeptidase N
HB365_RS06815	COG1605	Chorismate mutase
HB365_RS06830	COG1309	transcriptional regulator
HB365_RS06840	COG0668	transmembrane transport
HB365_RS06875	COG4773	Receptor
HB365_RS06895	COG0488	(ABC) transporter
HB365_RS06900	COG0589	response to stress
HB365_RS06925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB365_RS06935	COG3135	benzoate transporter
HB365_RS06940	COG1522	sequence-specific DNA binding
HB365_RS06950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB365_RS06955	COG0583	DNA-binding transcription factor activity
HB365_RS06965	COG0183	Belongs to the thiolase family
HB365_RS06975	COG2030	dehydratase
HB365_RS06995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB365_RS07005	COG0824	Thioesterase
HB365_RS07010	COG1454	alcohol dehydrogenase
HB365_RS07020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB365_RS07040	COG0069	glutamate synthase activity
HB365_RS07205	COG5410	chromosome segregation
HB365_RS07330	COG0739	heme binding
HB365_RS07395	COG2814	Major facilitator Superfamily
HB365_RS07410	COG0511	ligase activity, forming carbon-carbon bonds
HB365_RS07430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB365_RS07430	COG1116	anion transmembrane transporter activity
HB365_RS07435	COG0745	RESPONSE REGULATOR receiver
HB365_RS07445	COG2146	nitrite reductase [NAD(P)H] activity
HB365_RS07445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB365_RS07450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB365_RS07455	COG0243	molybdopterin cofactor binding
HB365_RS07465	COG0243	molybdopterin cofactor binding
HB365_RS07470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB365_RS07485	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB365_RS07485	COG0315	cyclic pyranopterin monophosphate synthase activity
HB365_RS07490	COG0303	'Molybdopterin
HB365_RS07500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB365_RS07505	COG0697	spore germination
HB365_RS07525	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB365_RS07530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB365_RS07585	COG2204	response regulator
HB365_RS07590	COG3852	Histidine kinase
HB365_RS07610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB365_RS07615	COG0575	Belongs to the CDS family
HB365_RS07650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB365_RS07665	COG2137	regulation of response to DNA damage stimulus
HB365_RS07675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB365_RS07680	COG1011	Hydrolase
HB365_RS07705	COG1522	sequence-specific DNA binding
HB365_RS07715	COG1113	amino acid transport
HB365_RS07730	COG0659	secondary active sulfate transmembrane transporter activity
HB365_RS07735	COG2135	peptidase activity
HB365_RS07750	COG5001	Diguanylate cyclase
HB365_RS07750	COG3300	MHYT domain
HB365_RS07770	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB365_RS07770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB365_RS07770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB365_RS07775	COG1105	Belongs to the carbohydrate kinase PfkB family
HB365_RS07780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB365_RS07780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB365_RS07810	COG0024	Methionine aminopeptidase
HB365_RS07815	COG0583	DNA-binding transcription factor activity
HB365_RS07825	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB365_RS07830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB365_RS07835	COG0517	IMP dehydrogenase activity
HB365_RS07835	COG0516	GMP reductase activity
HB365_RS07860	COG0552	protein localization to endoplasmic reticulum
HB365_RS07870	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB365_RS07885	COG4890	Cyd operon protein YbgT
HB365_RS07890	COG1294	oxidase, subunit
HB365_RS07905	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB365_RS07915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB365_RS07920	COG4774	siderophore transport
HB365_RS07935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB365_RS07940	COG0569	domain protein
HB365_RS07945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB365_RS07975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB365_RS07980	COG0542	response to heat
HB365_RS08005	COG1902	pentaerythritol trinitrate reductase activity
HB365_RS08005	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB365_RS08050	COG2323	membrane
HB365_RS08055	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB365_RS08065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB365_RS08070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB365_RS08075	COG0183	Belongs to the thiolase family
HB365_RS08080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB365_RS08085	COG0596	Alpha beta hydrolase
HB365_RS08090	COG2271	Major facilitator Superfamily
HB365_RS08095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB365_RS08100	COG3485	protocatechuate 3,4-dioxygenase
HB365_RS08105	COG3485	protocatechuate 3,4-dioxygenase
HB365_RS08110	COG0710	3-dehydroquinate dehydratase activity
HB365_RS08115	COG3420	alginic acid biosynthetic process
HB365_RS08120	COG3659	wide pore channel activity
HB365_RS08125	COG4993	Dehydrogenase
HB365_RS08135	COG2391	methyltransferase activity
HB365_RS08150	COG1414	Transcriptional regulator
HB365_RS08155	COG0583	DNA-binding transcription factor activity
HB365_RS08160	COG1960	acyl-CoA dehydrogenase activity
HB365_RS08185	COG2814	Major facilitator Superfamily
HB365_RS08195	COG0154	amidase activity
HB365_RS08215	COG4638	Rieske (2fe-2S)
HB365_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS08235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB365_RS08245	COG3733	amine oxidase
HB365_RS08255	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS08265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB365_RS08270	COG0183	Belongs to the thiolase family
HB365_RS08275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB365_RS08280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB365_RS08290	COG4829	muconolactone delta-isomerase
HB365_RS08295	COG4948	Mandelate Racemase Muconate Lactonizing
HB365_RS08300	COG0583	DNA-binding transcription factor activity
HB365_RS08310	COG2186	Transcriptional regulator
HB365_RS08330	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS08350	COG1960	acyl-CoA dehydrogenase activity
HB365_RS08355	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS08360	COG3829	transcription factor binding
HB365_RS08370	COG3162	membrane
HB365_RS08385	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS08400	COG0753	catalase activity
HB365_RS08420	COG1846	Transcriptional regulator
HB365_RS08425	COG1902	pentaerythritol trinitrate reductase activity
HB365_RS08425	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB365_RS08435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB365_RS08465	COG1309	transcriptional regulator
HB365_RS08475	COG1335	isochorismatase
HB365_RS08480	COG0583	DNA-binding transcription factor activity
HB365_RS08490	COG0475	glutathione-regulated potassium exporter activity
HB365_RS08490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB365_RS08500	COG1473	amidohydrolase
HB365_RS08510	COG2831	hemolysin activation secretion protein
HB365_RS08515	COG3210	domain, Protein
HB365_RS08545	COG2188	Transcriptional regulator
HB365_RS08560	COG0583	DNA-binding transcription factor activity
HB365_RS08590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB365_RS08610	COG1566	PFAM secretion protein HlyD family protein
HB365_RS08625	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS08630	COG0129	dihydroxy-acid dehydratase activity
HB365_RS08640	COG0583	DNA-binding transcription factor activity
HB365_RS08645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB365_RS08655	COG2084	Dehydrogenase
HB365_RS08660	COG2207	Transcriptional regulator
HB365_RS08675	COG1064	alcohol dehydrogenase
HB365_RS08690	COG1120	ATPase activity
HB365_RS08710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB365_RS08825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB365_RS08875	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS08890	COG2207	Transcriptional regulator
HB365_RS08900	COG2205	protein histidine kinase activity
HB365_RS08905	COG0745	RESPONSE REGULATOR receiver
HB365_RS08910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS08915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB365_RS08920	COG1538	Outer membrane efflux protein
HB365_RS08930	COG2072	flavoprotein involved in K transport
HB365_RS08950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB365_RS08970	COG3539	Fimbrial protein
HB365_RS09000	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB365_RS09010	COG0753	catalase activity
HB365_RS09025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB365_RS09090	COG3433	isochorismatase activity
HB365_RS09090	COG1535	isochorismatase
HB365_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS09100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB365_RS09105	COG4149	molybdate abc transporter
HB365_RS09110	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB365_RS09120	COG4638	Rieske (2fe-2S)
HB365_RS09125	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB365_RS09130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB365_RS09130	COG0543	2 iron, 2 sulfur cluster binding
HB365_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS09170	COG2207	Transcriptional regulator
HB365_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS09185	COG2610	gluconate transmembrane transporter activity
HB365_RS09195	COG0583	DNA-binding transcription factor activity
HB365_RS09205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB365_RS09210	COG2031	fatty acid transporter
HB365_RS09215	COG0183	Belongs to the thiolase family
HB365_RS09220	COG0583	DNA-binding transcription factor activity
HB365_RS09225	COG0583	DNA-binding transcription factor activity
HB365_RS09240	COG1027	Aspartate ammonia-lyase
HB365_RS09250	COG0477	Major facilitator Superfamily
HB365_RS09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB365_RS09275	COG4521	taurine ABC transporter
HB365_RS09290	COG2188	Transcriptional regulator
HB365_RS09300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB365_RS09305	COG1733	regulation of RNA biosynthetic process
HB365_RS09310	COG3708	Transcriptional regulator
HB365_RS09310	COG2207	Transcriptional regulator
HB365_RS09325	COG0730	response to heat
HB365_RS09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB365_RS09335	COG3453	Protein conserved in bacteria
HB365_RS09345	COG3781	membrane
HB365_RS09350	COG1063	alcohol dehydrogenase
HB365_RS09360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB365_RS09365	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB365_RS09370	COG0022	dehydrogenase e1 component
HB365_RS09375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB365_RS09380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB365_RS09395	COG3706	GGDEF domain
HB365_RS09410	COG0133	tryptophan synthase activity
HB365_RS09420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB365_RS09455	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB365_RS09480	COG2226	methyltransferase
HB365_RS09535	COG0842	Transport permease protein
HB365_RS09545	COG0842	Transport permease protein
HB365_RS09550	COG1131	(ABC) transporter
HB365_RS09565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB365_RS09570	COG4773	Receptor
HB365_RS09590	COG0730	response to heat
HB365_RS09595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB365_RS09615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB365_RS09670	COG4264	IucA IucC family
HB365_RS09675	COG4264	IucA IucC family
HB365_RS09695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB365_RS09710	COG1960	acyl-CoA dehydrogenase activity
HB365_RS09715	COG1960	acyl-CoA dehydrogenase activity
HB365_RS09720	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB365_RS09725	COG2207	Transcriptional regulator
HB365_RS09730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB365_RS09735	COG0776	regulation of translation
HB365_RS09760	COG0822	iron-sulfur transferase activity
HB365_RS09765	COG0316	Belongs to the HesB IscA family
HB365_RS09795	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB365_RS09815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB365_RS09820	COG0702	epimerase
HB365_RS09855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB365_RS09865	COG0339	signal peptide processing
HB365_RS09915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB365_RS09920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB365_RS09950	COG0776	regulation of translation
HB365_RS10015	COG0084	hydrolase, TatD family'
HB365_RS10035	COG1663	tetraacyldisaccharide 4'-kinase activity
HB365_RS10040	COG1132	(ABC) transporter
HB365_RS10050	COG0811	peptide transport
HB365_RS10055	COG1475	DNA binding
HB365_RS10060	COG1192	Involved in chromosome partitioning
HB365_RS10070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB365_RS10085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB365_RS10090	COG0191	fructose-bisphosphate aldolase activity
HB365_RS10110	COG0424	maF-like protein
HB365_RS10115	COG2850	peptidyl-arginine hydroxylation
HB365_RS10125	COG0640	Transcriptional regulator
HB365_RS10140	COG3619	membrane
HB365_RS10145	COG3122	Protein conserved in bacteria
HB365_RS10150	COG1132	(ABC) transporter
HB365_RS10170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB365_RS10175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB365_RS10185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB365_RS10185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB365_RS10185	COG0506	proline dehydrogenase activity
HB365_RS10190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB365_RS10205	COG3698	Phosphodiester glycosidase
HB365_RS10215	COG2353	YceI-like domain
HB365_RS10225	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB365_RS10270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB365_RS10270	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB365_RS10295	COG3539	Fimbrial protein
HB365_RS10300	COG3121	Chaperone
HB365_RS10325	COG0697	spore germination
HB365_RS10335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB365_RS10345	COG0583	DNA-binding transcription factor activity
HB365_RS10365	COG1309	transcriptional regulator
HB365_RS10380	COG1522	sequence-specific DNA binding
HB365_RS10390	COG1126	abc transporter atp-binding protein
HB365_RS10395	COG0765	amino acid transport
HB365_RS10400	COG0765	amino acid transport
HB365_RS10430	COG1464	Belongs to the NlpA lipoprotein family
HB365_RS10440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB365_RS10445	COG2011	ABC-type metal ion transport system permease component
HB365_RS10450	COG0012	GTP binding
HB365_RS10475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB365_RS10515	COG0386	Belongs to the glutathione peroxidase family
HB365_RS10525	COG0436	Aminotransferase
HB365_RS10565	COG3634	alkyl hydroperoxide reductase activity
HB365_RS10580	COG0583	DNA-binding transcription factor activity
HB365_RS10585	COG0798	PFAM Bile acid sodium symporter
HB365_RS10590	COG0640	Transcriptional regulator
HB365_RS10605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB365_RS10615	COG0583	DNA-binding transcription factor activity
HB365_RS10625	COG1953	Uracil, thiamine, allantoin
HB365_RS10635	COG2175	clavaminate synthase activity
HB365_RS10640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB365_RS10645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB365_RS10650	COG4521	taurine ABC transporter
HB365_RS10660	COG0477	Major facilitator Superfamily
HB365_RS10680	COG1271	oxidase subunit
HB365_RS10685	COG1294	oxidase, subunit
HB365_RS10695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB365_RS10715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB365_RS10735	COG3052	prosthetic group binding
HB365_RS10740	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB365_RS10750	COG2814	Major facilitator Superfamily
HB365_RS10770	COG1346	cytolysis
HB365_RS10780	COG0583	DNA-binding transcription factor activity
HB365_RS10785	COG0625	glutathione transferase activity
HB365_RS10790	COG0625	glutathione transferase activity
HB365_RS10795	COG0583	DNA-binding transcription factor activity
HB365_RS10810	COG1045	serine acetyltransferase
HB365_RS10815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB365_RS10820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB365_RS10830	COG1280	lysine exporter protein (LysE YggA)
HB365_RS10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB365_RS10850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB365_RS10855	COG1126	abc transporter atp-binding protein
HB365_RS10860	COG0765	amino acid transport
HB365_RS10865	COG0765	amino acid transport
HB365_RS10885	COG0784	Response regulator, receiver
HB365_RS10885	COG2205	protein histidine kinase activity
HB365_RS10905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB365_RS10925	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS10975	COG0583	DNA-binding transcription factor activity
HB365_RS10995	COG0318	PFAM AMP-dependent synthetase and ligase
HB365_RS11000	COG1309	transcriptional regulator
HB365_RS11005	COG1960	acyl-CoA dehydrogenase activity
HB365_RS11010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB365_RS11015	COG1024	Enoyl-CoA hydratase
HB365_RS11020	COG4770	biotin carboxylase activity
HB365_RS11030	COG0583	DNA-binding transcription factor activity
HB365_RS11045	COG1960	acyl-CoA dehydrogenase activity
HB365_RS11055	COG2814	Major facilitator Superfamily
HB365_RS11065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB365_RS11070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB365_RS11075	COG2814	Major facilitator Superfamily
HB365_RS11080	COG1960	acyl-CoA dehydrogenase activity
HB365_RS11085	COG1024	Enoyl-CoA hydratase
HB365_RS11090	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS11095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB365_RS11100	COG0183	Belongs to the thiolase family
HB365_RS11110	COG2814	Major facilitator Superfamily
HB365_RS11120	COG1024	Enoyl-CoA hydratase
HB365_RS11135	COG1960	acyl-CoA dehydrogenase activity
HB365_RS11140	COG2814	Major facilitator Superfamily
HB365_RS11145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB365_RS11150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB365_RS11165	COG3842	ATPase activity
HB365_RS11170	COG1840	ABC-type Fe3 transport system, periplasmic component
HB365_RS11180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB365_RS11185	COG1414	Transcriptional regulator
HB365_RS11195	COG0583	DNA-binding transcription factor activity
HB365_RS11200	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB365_RS11205	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS11215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB365_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS11230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB365_RS11235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB365_RS11240	COG2267	carboxylic ester hydrolase activity
HB365_RS11260	COG3038	cytochrome b561
HB365_RS11265	COG0753	catalase activity
HB365_RS11300	COG2050	protein possibly involved in aromatic compounds catabolism
HB365_RS11310	COG3327	negative regulation of DNA-templated transcription, initiation
HB365_RS11315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB365_RS11320	COG0183	Belongs to the thiolase family
HB365_RS11325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB365_RS11330	COG1024	Enoyl-CoA hydratase
HB365_RS11335	COG1024	Enoyl-CoA hydratase
HB365_RS11340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB365_RS11345	COG2151	metal-sulfur cluster biosynthetic enzyme
HB365_RS11350	COG3396	Phenylacetate-CoA oxygenase
HB365_RS11355	COG3460	Phenylacetate-CoA oxygenase
HB365_RS11360	COG3396	Phenylacetate-CoA oxygenase
HB365_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS11365	COG2030	dehydratase
HB365_RS11370	COG1760	l-serine dehydratase
HB365_RS11375	COG0531	amino acid
HB365_RS11380	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS11395	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB365_RS11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB365_RS11425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB365_RS11435	COG0789	Transcriptional regulator
HB365_RS11450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB365_RS11465	COG2807	transmembrane transport
HB365_RS11470	COG0590	tRNA wobble adenosine to inosine editing
HB365_RS11585	COG1116	anion transmembrane transporter activity
HB365_RS11590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB365_RS11600	COG0864	Transcriptional regulator
HB365_RS11620	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB365_RS11625	COG0439	Biotin carboxylase
HB365_RS11640	COG1063	alcohol dehydrogenase
HB365_RS11650	COG1309	transcriptional regulator
HB365_RS11670	COG0038	chloride channel
HB365_RS11675	COG4770	biotin carboxylase activity
HB365_RS11695	COG1914	H( )-stimulated, divalent metal cation uptake system
HB365_RS11700	COG0583	DNA-binding transcription factor activity
HB365_RS11715	COG3209	COG3209 Rhs family protein
HB365_RS11720	COG3501	Rhs element vgr protein
HB365_RS11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB365_RS11770	COG2814	Major facilitator Superfamily
HB365_RS11780	COG1560	Kdo2-lipid A biosynthetic process
HB365_RS11790	COG5006	permease, DMT superfamily
HB365_RS11795	COG1522	sequence-specific DNA binding
HB365_RS11810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB365_RS11820	COG4122	O-methyltransferase activity
HB365_RS11850	COG1538	Outer membrane efflux protein
HB365_RS11860	COG1137	ATPase activity
HB365_RS11865	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB365_RS11875	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB365_RS11880	COG0517	IMP dehydrogenase activity
HB365_RS11880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB365_RS11920	COG2814	Major facilitator Superfamily
HB365_RS11955	COG1278	Cold shock
HB365_RS11960	COG1280	lysine exporter protein (LysE YggA)
HB365_RS11995	COG1570	exodeoxyribonuclease VII activity
HB365_RS12045	COG0583	DNA-binding transcription factor activity
HB365_RS12050	COG4638	Rieske (2fe-2S)
HB365_RS12055	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB365_RS12060	COG0543	2 iron, 2 sulfur cluster binding
HB365_RS12060	COG0633	Ferredoxin
HB365_RS12065	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS12070	COG3135	benzoate transporter
HB365_RS12075	COG2814	Major facilitator Superfamily
HB365_RS12090	COG1643	Atp-dependent helicase
HB365_RS12095	COG0450	alkyl hydroperoxide reductase
HB365_RS12105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB365_RS12115	COG3634	alkyl hydroperoxide reductase activity
HB365_RS12135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB365_RS12140	COG0625	glutathione transferase activity
HB365_RS12150	COG2885	chlorophyll binding
HB365_RS12185	COG0542	response to heat
HB365_RS12200	COG1765	OsmC-like protein
HB365_RS12215	COG0667	Aldo Keto reductase
HB365_RS12230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB365_RS12240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB365_RS12250	COG0527	aspartate kinase activity
HB365_RS12260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB365_RS12270	COG3038	cytochrome b561
HB365_RS12275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB365_RS12280	COG2252	PERMEase
HB365_RS12290	COG2072	flavoprotein involved in K transport
HB365_RS12305	COG1741	Belongs to the pirin family
HB365_RS12310	COG1309	transcriptional regulator
HB365_RS12335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HB365_RS12375	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB365_RS12375	COG1902	pentaerythritol trinitrate reductase activity
HB365_RS12385	COG4251	negative regulation of phosphorylation
HB365_RS12385	COG3706	GGDEF domain
HB365_RS12385	COG2203	Gaf domain
HB365_RS12385	COG5001	Diguanylate cyclase
HB365_RS12395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB365_RS12415	COG4172	Belongs to the ABC transporter superfamily
HB365_RS12420	COG4239	(ABC) transporter, permease
HB365_RS12425	COG4174	ABC transporter (Permease)
HB365_RS12435	COG1388	LysM domain
HB365_RS12435	COG0741	lytic transglycosylase activity
HB365_RS12435	COG1388	LysM domain
HB365_RS12435	COG0741	lytic transglycosylase activity
HB365_RS12440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB365_RS12480	COG0583	DNA-binding transcription factor activity
HB365_RS12485	COG1279	arginine transmembrane transporter activity
HB365_RS12505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB365_RS12510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB365_RS12515	COG0006	proline dipeptidase activity
HB365_RS12550	COG2194	sulfuric ester hydrolase activity
HB365_RS12595	COG0739	heme binding
HB365_RS12920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB365_RS12945	COG3384	dioxygenase
HB365_RS12955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB365_RS12960	COG2878	Part of a membrane complex involved in electron transport
HB365_RS12965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB365_RS12990	COG0768	penicillin binding
HB365_RS12995	COG0742	ribosomal rna small subunit methyltransferase
HB365_RS13010	COG0830	nickel cation binding
HB365_RS13020	COG0804	urea catabolic process
HB365_RS13060	COG1253	flavin adenine dinucleotide binding
HB365_RS13065	COG2851	Citrate transporter
HB365_RS13120	COG1773	rubredoxin
HB365_RS13125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB365_RS13135	COG0583	DNA-binding transcription factor activity
HB365_RS13160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB365_RS13165	COG4181	ATPase activity
HB365_RS13210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB365_RS13230	COG0306	phosphate transporter
HB365_RS13240	COG3958	Transketolase
HB365_RS13245	COG3959	Transketolase, thiamine diphosphate binding domain
HB365_RS13250	COG2271	Major facilitator Superfamily
HB365_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS13260	COG0583	DNA-binding transcription factor activity
HB365_RS13275	COG2223	nitrite transmembrane transporter activity
HB365_RS13280	COG2207	Transcriptional regulator
HB365_RS13285	COG2066	Belongs to the glutaminase family
HB365_RS13290	COG0242	peptide deformylase activity
HB365_RS13295	COG0477	Major facilitator Superfamily
HB365_RS13305	COG0028	Belongs to the TPP enzyme family
HB365_RS13320	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS13325	COG2267	carboxylic ester hydrolase activity
HB365_RS13335	COG2271	Major facilitator Superfamily
HB365_RS13340	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB365_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS13370	COG1414	Transcriptional regulator
HB365_RS13385	COG1024	Enoyl-CoA hydratase
HB365_RS13395	COG1215	transferase activity, transferring glycosyl groups
HB365_RS13400	COG1649	PFAM Uncharacterised BCR, COG1649
HB365_RS13400	COG0726	polysaccharide deacetylase
HB365_RS13410	COG4681	YaeQ
HB365_RS13420	COG0523	cobalamin synthesis protein
HB365_RS13430	COG1607	acyl-coa hydrolase
HB365_RS13440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB365_RS13445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB365_RS13450	COG1309	transcriptional regulator
HB365_RS13475	COG2040	homocysteine
HB365_RS13480	COG0531	amino acid
HB365_RS13535	COG1595	DNA-templated transcription, initiation
HB365_RS13545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB365_RS13550	COG0477	Major facilitator Superfamily
HB365_RS13570	COG0084	hydrolase, TatD family'
HB365_RS13605	COG0629	single-stranded DNA binding
HB365_RS13660	COG0582	viral genome integration into host DNA
HB365_RS13755	COG0592	DNA-directed DNA polymerase activity
HB365_RS13795	COG2026	Addiction module toxin, RelE StbE family
HB365_RS13990	COG1484	DNA-dependent DNA replication
HB365_RS14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB365_RS14150	COG0405	Gamma-glutamyltransferase
HB365_RS14155	COG2814	Major facilitator Superfamily
HB365_RS14165	COG2050	protein possibly involved in aromatic compounds catabolism
HB365_RS14180	COG1090	epimerase
HB365_RS14200	COG0420	3'-5' exonuclease activity
HB365_RS14225	COG0735	belongs to the Fur family
HB365_RS14230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB365_RS14250	COG0121	glutamine amidotransferase
HB365_RS14265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB365_RS14275	COG0210	DNA helicase
HB365_RS14280	COG2885	chlorophyll binding
HB365_RS14285	COG0204	Acyl-transferase
HB365_RS14300	COG2894	cell division
HB365_RS14325	COG1280	lysine exporter protein (LysE YggA)
HB365_RS14330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB365_RS14330	COG1674	ftsk spoiiie
HB365_RS14335	COG0492	ferredoxin-NADP+ reductase activity
HB365_RS14340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB365_RS14350	COG0456	acetyltransferase
HB365_RS14410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB365_RS14410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB365_RS14430	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS14450	COG0473	3-isopropylmalate dehydrogenase activity
HB365_RS14455	COG0583	DNA-binding transcription factor activity
HB365_RS14475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB365_RS14500	COG0564	pseudouridine synthase activity
HB365_RS14510	COG0358	DNA primase activity
HB365_RS14525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB365_RS14555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB365_RS14585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB365_RS14595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB365_RS14595	COG0351	phosphomethylpyrimidine kinase
HB365_RS14595	COG0352	thiamine-phosphate diphosphorylase activity
HB365_RS14600	COG1652	LysM domain
HB365_RS14625	COG1399	metal-binding, possibly nucleic acid-binding protein
HB365_RS14630	COG3101	peptidyl-lysine hydroxylation
HB365_RS14635	COG0009	L-threonylcarbamoyladenylate synthase
HB365_RS14640	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB365_RS14645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB365_RS14660	COG4106	trans-aconitate 2-methyltransferase activity
HB365_RS14675	COG0596	Alpha beta hydrolase
HB365_RS14675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB365_RS14675	COG2226	methyltransferase
HB365_RS14680	COG1877	trehalose-phosphatase activity
HB365_RS14685	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB365_RS14690	COG2223	nitrite transmembrane transporter activity
HB365_RS14710	COG1196	nuclear chromosome segregation
HB365_RS14720	COG0730	response to heat
HB365_RS14735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB365_RS14745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB365_RS14795	COG0489	protein tyrosine kinase activity
HB365_RS14805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB365_RS14805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB365_RS14835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB365_RS14840	COG2081	HI0933 family
HB365_RS14850	COG0668	transmembrane transport
HB365_RS14870	COG0583	DNA-binding transcription factor activity
HB365_RS14890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB365_RS14895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB365_RS14925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB365_RS14960	COG2205	protein histidine kinase activity
HB365_RS14965	COG0745	RESPONSE REGULATOR receiver
HB365_RS14985	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB365_RS14995	COG2205	protein histidine kinase activity
HB365_RS15065	COG4993	Dehydrogenase
HB365_RS15085	COG0384	phenazine biosynthesis protein PhzF
HB365_RS15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB365_RS15120	COG0583	DNA-binding transcription factor activity
HB365_RS15140	COG1473	amidohydrolase
HB365_RS15150	COG0583	DNA-binding transcription factor activity
HB365_RS15165	COG0583	DNA-binding transcription factor activity
HB365_RS15170	COG1053	succinate dehydrogenase
HB365_RS15180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB365_RS15185	COG2814	Major facilitator Superfamily
HB365_RS15190	COG1960	acyl-CoA dehydrogenase activity
HB365_RS15195	COG0583	DNA-binding transcription factor activity
HB365_RS15200	COG1063	alcohol dehydrogenase
HB365_RS15230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB365_RS15235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB365_RS15240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB365_RS15255	COG3667	copper resistance
HB365_RS15260	COG2132	Multicopper oxidase
HB365_RS15270	COG0561	phosphatase activity
HB365_RS15275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB365_RS15300	COG1214	PFAM Peptidase M22, glycoprotease
HB365_RS15355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB365_RS15365	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB365_RS15370	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB365_RS15375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB365_RS15435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB365_RS15445	COG1846	Transcriptional regulator
HB365_RS15450	COG1764	response to oxidative stress
HB365_RS15500	COG0037	tRNA processing
HB365_RS15510	COG0248	Ppx GppA phosphatase
HB365_RS15540	COG0072	phenylalanine-tRNA ligase activity
HB365_RS15580	COG1238	metal cluster binding
HB365_RS15585	COG0625	glutathione transferase activity
HB365_RS15600	COG0318	PFAM AMP-dependent synthetase and ligase
HB365_RS15605	COG3028	Belongs to the UPF0307 family
HB365_RS15610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB365_RS15630	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB365_RS15635	COG0617	tRNA 3'-terminal CCA addition
HB365_RS15640	COG1555	photosystem II stabilization
HB365_RS15645	COG3956	TIGRFAM MazG family protein
HB365_RS15655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB365_RS15675	COG5002	protein histidine kinase activity
HB365_RS15675	COG2205	protein histidine kinase activity
HB365_RS15675	COG0784	Response regulator, receiver
HB365_RS15680	COG1024	Enoyl-CoA hydratase
HB365_RS15685	COG2084	Dehydrogenase
HB365_RS15690	COG3622	Belongs to the hyi family
HB365_RS15720	COG0697	spore germination
HB365_RS15730	COG2814	Major facilitator Superfamily
HB365_RS15735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB365_RS15745	COG0583	DNA-binding transcription factor activity
HB365_RS15755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB365_RS15770	COG0084	hydrolase, TatD family'
HB365_RS15785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB365_RS15815	COG0440	acetolactate synthase activity
HB365_RS15820	COG0028	Belongs to the TPP enzyme family
HB365_RS15845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB365_RS15850	COG1136	(ABC) transporter
HB365_RS15850	COG0577	efflux transmembrane transporter activity
HB365_RS15855	COG1538	Outer membrane efflux protein
HB365_RS15870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB365_RS15875	COG1162	GTPase activity
HB365_RS15885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB365_RS15905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB365_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS15950	COG2986	histidine ammonia-lyase
HB365_RS15965	COG0318	PFAM AMP-dependent synthetase and ligase
HB365_RS15975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB365_RS16020	COG1426	Protein conserved in bacteria
HB365_RS16055	COG0793	Belongs to the peptidase S41A family
HB365_RS16070	COG2267	carboxylic ester hydrolase activity
HB365_RS16080	COG1012	belongs to the aldehyde dehydrogenase family
HB365_RS16085	COG3265	gluconokinase activity
HB365_RS16095	COG0800	Aldolase
HB365_RS16110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB365_RS16115	COG0857	belongs to the CobB CobQ family
HB365_RS16115	COG0280	phosphate acetyltransferase
HB365_RS16120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB365_RS16120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB365_RS16140	COG0740	serine-type endopeptidase activity
HB365_RS16150	COG4774	siderophore transport
HB365_RS16160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB365_RS16170	COG2813	Specifically methylates the guanine in position
HB365_RS16170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB365_RS16270	COG0788	formyltetrahydrofolate deformylase activity
HB365_RS16295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB365_RS16295	COG4651	solute:proton antiporter activity
HB365_RS16315	COG0724	RNA recognition motif
HB365_RS16320	COG0210	DNA helicase
HB365_RS16345	COG1733	regulation of RNA biosynthetic process
HB365_RS16355	COG2900	Belongs to the SlyX family
HB365_RS16365	COG1280	lysine exporter protein (LysE YggA)
HB365_RS16370	COG1560	Kdo2-lipid A biosynthetic process
HB365_RS16380	COG1301	dicarboxylic acid transport
HB365_RS16435	COG0473	3-isopropylmalate dehydrogenase activity
HB365_RS16500	COG0583	DNA-binding transcription factor activity
HB365_RS16510	COG0625	glutathione transferase activity
HB365_RS16515	COG2378	regulation of single-species biofilm formation
HB365_RS16520	COG0546	phosphoglycolate phosphatase activity
HB365_RS16535	COG1530	ribonuclease E activity
HB365_RS16540	COG0318	PFAM AMP-dependent synthetase and ligase
HB365_RS16555	COG0583	DNA-binding transcription factor activity
HB365_RS16560	COG4221	oxidoreductase activity
HB365_RS16565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB365_RS16575	COG0534	Mate efflux family protein
HB365_RS16590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB365_RS16630	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB365_RS16635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB365_RS16650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB365_RS16660	COG0644	oxidoreductase
HB365_RS16660	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB365_RS16665	COG0425	Belongs to the sulfur carrier protein TusA family
HB365_RS16670	COG4535	Mg2 and Co2 transporter CorC
HB365_RS16680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB365_RS16700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB365_RS16705	COG0475	glutathione-regulated potassium exporter activity
HB365_RS16705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB365_RS16710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HB365_RS16720	COG0484	heat shock protein binding
HB365_RS16725	COG0789	Transcriptional regulator
HB365_RS16730	COG0598	Magnesium transport protein CorA
HB365_RS16750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB365_RS16755	COG1074	ATP-dependent DNA helicase activity
HB365_RS16760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB365_RS16780	COG2226	methyltransferase
HB365_RS16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB365_RS16800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB365_RS16815	COG2111	Na H antiporter
HB365_RS16815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB365_RS16820	COG1006	Multisubunit Na H antiporter MnhC subunit
HB365_RS16825	COG0651	ATP synthesis coupled electron transport
HB365_RS16835	COG2212	antiporter activity
HB365_RS16855	COG0195	Participates in both transcription termination and antitermination
HB365_RS16905	COG0237	dephospho-CoA kinase activity
HB365_RS16915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB365_RS16930	COG0497	DNA recombination
HB365_RS16940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB365_RS16970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB365_RS16970	COG2169	Transcriptional regulator
HB365_RS16975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB365_RS17040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB365_RS17055	COG0326	Molecular chaperone. Has ATPase activity
HB365_RS17070	COG2056	Na+-H+ antiporter family
HB365_RS17075	COG0596	Alpha beta hydrolase
HB365_RS17170	COG0546	phosphoglycolate phosphatase activity
HB365_RS17175	COG1716	ATPase activity
HB365_RS17220	COG0181	hydroxymethylbilane synthase activity
HB365_RS17230	COG3275	phosphorelay sensor kinase activity
HB365_RS17250	COG1538	Outer membrane efflux protein
HB365_RS17255	COG0697	spore germination
HB365_RS17280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB365_RS17285	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB365_RS17290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB365_RS17295	COG0772	Belongs to the SEDS family
HB365_RS17320	COG4974	Belongs to the 'phage' integrase family
HB365_RS17325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB365_RS17335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB365_RS17345	COG2197	response regulator
HB365_RS17360	COG0793	Belongs to the peptidase S41A family
HB365_RS17365	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB365_RS17370	COG0795	lipopolysaccharide-transporting ATPase activity
HB365_RS17410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB365_RS17410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB365_RS17420	COG0004	ammonium transporteR
HB365_RS17425	COG0347	Belongs to the P(II) protein family
HB365_RS17435	COG0606	chelatase, subunit chli
HB365_RS17510	COG1061	Type III restriction enzyme res subunit
HB365_RS17525	COG0659	secondary active sulfate transmembrane transporter activity
HB365_RS17530	COG0589	response to stress
HB365_RS17560	COG0606	chelatase, subunit chli
HB365_RS17575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB365_RS17590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB365_RS17605	COG0318	PFAM AMP-dependent synthetase and ligase
HB365_RS17615	COG0477	Major facilitator Superfamily
HB365_RS17620	COG2860	membrane
HB365_RS17630	COG1253	flavin adenine dinucleotide binding
HB365_RS17650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB365_RS17685	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB365_RS17695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB365_RS17730	COG1309	transcriptional regulator
HB365_RS17765	COG0758	DNA mediated transformation
HB365_RS17775	COG0697	spore germination
HB365_RS17780	COG1309	transcriptional regulator
HB365_RS17795	COG0386	Belongs to the glutathione peroxidase family
HB365_RS17860	COG1121	(ABC) transporter
HB365_RS17865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB365_RS17870	COG1280	lysine exporter protein (LysE YggA)
HB365_RS17875	COG2837	iron assimilation
HB365_RS17885	COG0281	malic enzyme
HB365_RS17930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB365_RS17930	COG0519	Catalyzes the synthesis of GMP from XMP
HB365_RS17935	COG4399	Belongs to the UPF0754 family
HB365_RS17940	COG2259	Doxx family
HB365_RS17945	COG0586	Pfam SNARE associated Golgi protein
HB365_RS17960	COG1192	Involved in chromosome partitioning
HB365_RS17970	COG0271	Belongs to the BolA IbaG family
HB365_RS17990	COG2267	carboxylic ester hydrolase activity
HB365_RS18010	COG3321	synthase
HB365_RS18010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB365_RS18010	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HB365_RS18010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB365_RS18015	COG1960	acyl-CoA dehydrogenase activity
HB365_RS18025	COG2197	response regulator
HB365_RS18035	COG3916	Acyl-homoserine-lactone synthase
HB365_RS18040	COG0477	Major facilitator Superfamily
HB365_RS18045	COG1024	Enoyl-CoA hydratase
HB365_RS18050	COG1024	Enoyl-CoA hydratase
HB365_RS18055	COG1960	acyl-CoA dehydrogenase activity
HB365_RS18060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB365_RS18080	COG1113	amino acid transport
HB365_RS18085	COG1113	amino acid transport
HB365_RS18090	COG0251	oxidation-reduction process
HB365_RS18130	COG0564	pseudouridine synthase activity
HB365_RS18200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB365_RS18215	COG1802	Transcriptional regulator
HB365_RS18225	COG1448	Aminotransferase
HB365_RS18230	COG0277	FAD linked oxidase domain protein
HB365_RS18240	COG2186	Transcriptional regulator
HB365_RS18250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB365_RS18255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB365_RS18270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB365_RS18275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB365_RS18300	COG2244	polysaccharide biosynthetic process
HB365_RS18305	COG2089	acid synthase
HB365_RS18320	COG1083	cytidylyl-transferase
HB365_RS18325	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB365_RS18330	COG1086	Polysaccharide biosynthesis protein
HB365_RS18335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB365_RS18340	COG1596	polysaccharide export
HB365_RS18365	COG0728	peptidoglycan biosynthetic process
HB365_RS18370	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB365_RS18425	COG0546	phosphoglycolate phosphatase activity
HB365_RS18430	COG1028	Short-chain dehydrogenase reductase Sdr
HB365_RS18450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB365_RS18455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB365_RS18460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB365_RS18465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB365_RS18470	COG1116	anion transmembrane transporter activity
HB365_RS18475	COG1309	transcriptional regulator
HB365_RS18480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB365_RS18490	COG0196	riboflavin kinase activity
HB365_RS18495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB365_RS18505	COG1047	Peptidyl-prolyl cis-trans
HB365_RS18545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB365_RS18600	COG2951	lytic endotransglycosylase activity
HB365_RS18605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB365_RS18620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB365_RS18630	COG0671	phosphoesterase, PA-phosphatase related
HB365_RS18635	COG0861	Integral membrane protein TerC family
HB365_RS18645	COG0754	glutathionylspermidine amidase activity
HB365_RS18655	COG0402	S-adenosylhomocysteine deaminase activity
HB365_RS18670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB365_RS18675	COG1230	cation diffusion facilitator family transporter
HB365_RS18690	COG0706	membrane insertase activity