locus-tag	class	description
HB366_RS00010	COG0592	DNA-directed DNA polymerase activity
HB366_RS00020	COG0187	DNA topoisomerase II activity
HB366_RS00030	COG0586	Pfam SNARE associated Golgi protein
HB366_RS00035	COG0488	(ABC) transporter
HB366_RS00060	COG0596	Alpha beta hydrolase
HB366_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB366_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB366_RS00110	COG0733	neurotransmitter:sodium symporter activity
HB366_RS00150	COG2233	PERMEase
HB366_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS00200	COG2814	Major facilitator Superfamily
HB366_RS00205	COG0656	L-ascorbic acid biosynthetic process
HB366_RS00210	COG0583	DNA-binding transcription factor activity
HB366_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_RS00230	COG1064	alcohol dehydrogenase
HB366_RS00235	COG2818	Glycosylase
HB366_RS00250	COG1194	a g-specific adenine glycosylase
HB366_RS00270	COG2983	Belongs to the UPF0260 family
HB366_RS00275	COG2133	pyrroloquinoline quinone binding
HB366_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB366_RS00285	COG2116	formate transmembrane transporter activity
HB366_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_RS00310	COG1335	isochorismatase
HB366_RS00315	COG0385	Bile acid
HB366_RS00320	COG0534	Mate efflux family protein
HB366_RS00325	COG1683	Conserved Protein
HB366_RS00345	COG0625	glutathione transferase activity
HB366_RS00355	COG1113	amino acid transport
HB366_RS00365	COG0523	cobalamin synthesis protein
HB366_RS00375	COG2188	Transcriptional regulator
HB366_RS00405	COG0010	Belongs to the arginase family
HB366_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB366_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB366_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB366_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB366_RS00545	COG0534	Mate efflux family protein
HB366_RS00550	COG0436	Aminotransferase
HB366_RS00555	COG2733	membrane
HB366_RS00570	COG2918	glutathione biosynthetic process
HB366_RS00580	COG3501	Rhs element vgr protein
HB366_RS00585	COG0791	NLP P60 protein
HB366_RS00585	COG1388	LysM domain
HB366_RS00600	COG3150	esterase
HB366_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB366_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_RS00635	COG2233	PERMEase
HB366_RS00640	COG2351	hydroxyisourate hydrolase activity
HB366_RS00675	COG3706	GGDEF domain
HB366_RS00690	COG1393	Belongs to the ArsC family
HB366_RS00695	COG0708	Exodeoxyribonuclease III
HB366_RS00715	COG0189	ligase activity
HB366_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB366_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB366_RS00760	COG4942	peptidase
HB366_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB366_RS00780	COG2119	membrane
HB366_RS00785	COG4774	siderophore transport
HB366_RS00790	COG0426	domain, Protein
HB366_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB366_RS00835	COG1902	pentaerythritol trinitrate reductase activity
HB366_RS00840	COG1519	Transferase
HB366_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB366_RS00850	COG0668	transmembrane transport
HB366_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_RS00865	COG1335	isochorismatase
HB366_RS00870	COG1522	sequence-specific DNA binding
HB366_RS00875	COG3328	transposase activity
HB366_RS00900	COG2205	protein histidine kinase activity
HB366_RS00900	COG0784	Response regulator, receiver
HB366_RS00900	COG2198	Histidine kinase
HB366_RS00905	COG3162	membrane
HB366_RS00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB366_RS00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_RS00930	COG3706	GGDEF domain
HB366_RS00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB366_RS00945	COG1309	transcriptional regulator
HB366_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB366_RS00965	COG0351	phosphomethylpyrimidine kinase
HB366_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
HB366_RS00975	COG2814	Major facilitator Superfamily
HB366_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB366_RS01000	COG1113	amino acid transport
HB366_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB366_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS01025	COG1335	isochorismatase
HB366_RS01055	COG2814	Major facilitator Superfamily
HB366_RS01060	COG0583	DNA-binding transcription factor activity
HB366_RS01080	COG0667	Aldo Keto reductase
HB366_RS01110	COG1733	regulation of RNA biosynthetic process
HB366_RS01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_RS01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB366_RS01195	COG2329	Antibiotic biosynthesis monooxygenase
HB366_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB366_RS01255	COG0427	acetyl-CoA hydrolase
HB366_RS01270	COG0745	RESPONSE REGULATOR receiver
HB366_RS01280	COG0659	secondary active sulfate transmembrane transporter activity
HB366_RS01285	COG4221	oxidoreductase activity
HB366_RS01290	COG2873	o-acetylhomoserine
HB366_RS01295	COG0488	(ABC) transporter
HB366_RS01380	COG0833	amino acid
HB366_RS01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB366_RS01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB366_RS01445	COG2226	methyltransferase
HB366_RS01495	COG0070	glutamate synthase
HB366_RS01495	COG0069	glutamate synthase activity
HB366_RS01495	COG0067	glutamate synthase
HB366_RS01500	COG0493	'glutamate synthase
HB366_RS01510	COG1704	LemA family
HB366_RS01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB366_RS01535	COG3307	-O-antigen
HB366_RS01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB366_RS01570	COG0194	GDP metabolic process
HB366_RS01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB366_RS01640	COG5380	lipid catabolic process
HB366_RS01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB366_RS01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB366_RS01675	COG0277	FAD linked oxidase domain protein
HB366_RS01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB366_RS01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_RS01705	COG1289	transmembrane transporter activity
HB366_RS01715	COG0628	permease
HB366_RS01720	COG1192	Involved in chromosome partitioning
HB366_RS01750	COG0833	amino acid
HB366_RS01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB366_RS01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB366_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS01810	COG0583	DNA-binding transcription factor activity
HB366_RS01855	COG0517	IMP dehydrogenase activity
HB366_RS01860	COG1983	PspC domain protein
HB366_RS01870	COG1960	acyl-CoA dehydrogenase activity
HB366_RS01885	COG0408	coproporphyrinogen oxidase activity
HB366_RS01905	COG0513	Belongs to the DEAD box helicase family
HB366_RS01915	COG1127	ABC transporter
HB366_RS01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB366_RS01930	COG2854	intermembrane phospholipid transfer
HB366_RS01940	COG0598	Magnesium transport protein CorA
HB366_RS01950	COG0494	nUDIX hydrolase
HB366_RS01955	COG1040	competence protein
HB366_RS01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB366_RS01980	COG1946	Acyl-CoA thioesterase
HB366_RS01985	COG1301	dicarboxylic acid transport
HB366_RS02000	COG1959	2 iron, 2 sulfur cluster binding
HB366_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_RS02005	COG1017	nitric oxide dioxygenase activity
HB366_RS02010	COG0433	COG0433 Predicted ATPase
HB366_RS02015	COG0626	cystathionine gamma-synthase activity
HB366_RS02170	COG1960	acyl-CoA dehydrogenase activity
HB366_RS02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB366_RS02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB366_RS02210	COG0339	signal peptide processing
HB366_RS02215	COG0557	exoribonuclease II activity
HB366_RS02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB366_RS02265	COG2169	Transcriptional regulator
HB366_RS02270	COG0697	spore germination
HB366_RS02275	COG1295	ribonuclease BN
HB366_RS02310	COG1702	phosphate starvation-inducible protein PhoH
HB366_RS02320	COG0741	lytic transglycosylase activity
HB366_RS02320	COG0739	heme binding
HB366_RS02320	COG1196	nuclear chromosome segregation
HB366_RS02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB366_RS02355	COG1183	phosphatidylcholine synthase activity
HB366_RS02400	COG1960	acyl-CoA dehydrogenase activity
HB366_RS02405	COG1309	transcriptional regulator
HB366_RS02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB366_RS02425	COG1960	acyl-CoA dehydrogenase activity
HB366_RS02445	COG2969	positive regulation of protein catabolic process
HB366_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB366_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB366_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB366_RS02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB366_RS02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB366_RS02510	COG1408	metallophosphoesterase
HB366_RS02520	COG2199	diguanylate cyclase activity
HB366_RS02580	COG1607	acyl-coa hydrolase
HB366_RS02610	COG2350	Protein conserved in bacteria
HB366_RS02620	COG0613	PHP domain protein
HB366_RS02625	COG3781	membrane
HB366_RS02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB366_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB366_RS02650	COG1862	Preprotein translocase
HB366_RS02680	COG2205	protein histidine kinase activity
HB366_RS02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB366_RS02705	COG0726	polysaccharide deacetylase
HB366_RS02710	COG0463	Glycosyl transferase, family 2
HB366_RS02715	COG0438	transferase activity, transferring glycosyl groups
HB366_RS02780	COG0625	glutathione transferase activity
HB366_RS02785	COG0583	DNA-binding transcription factor activity
HB366_RS02790	COG1960	acyl-CoA dehydrogenase activity
HB366_RS02795	COG1960	acyl-CoA dehydrogenase activity
HB366_RS02805	COG2205	protein histidine kinase activity
HB366_RS02810	COG0745	RESPONSE REGULATOR receiver
HB366_RS02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB366_RS02835	COG2096	Adenosyltransferase
HB366_RS02885	COG0285	dihydrofolate synthase activity
HB366_RS02905	COG0450	alkyl hydroperoxide reductase
HB366_RS02920	COG0477	Major facilitator Superfamily
HB366_RS02925	COG1272	protein, Hemolysin III
HB366_RS02960	COG0183	Belongs to the thiolase family
HB366_RS02965	COG2207	Transcriptional regulator
HB366_RS02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_RS03005	COG0183	Belongs to the thiolase family
HB366_RS03015	COG2885	chlorophyll binding
HB366_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB366_RS03025	COG1690	Belongs to the RtcB family
HB366_RS03030	COG0833	amino acid
HB366_RS03040	COG2233	PERMEase
HB366_RS03070	COG2094	Belongs to the DNA glycosylase MPG family
HB366_RS03075	COG4772	TonB-dependent receptor
HB366_RS03090	COG1902	pentaerythritol trinitrate reductase activity
HB366_RS03095	COG0679	Auxin Efflux Carrier
HB366_RS03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_RS03110	COG0354	folic acid binding
HB366_RS03120	COG3189	MarR family transcriptional regulator
HB366_RS03125	COG2824	Alkylphosphonate utilization operon protein PhnA
HB366_RS03130	COG3422	double-strand break repair
HB366_RS03170	COG0840	transmembrane signaling receptor activity
HB366_RS03190	COG5510	response to toxic substance
HB366_RS03200	COG2832	Protein of unknown function (DUF454)
HB366_RS03205	COG1376	ErfK ybiS ycfS ynhG family protein
HB366_RS03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB366_RS03255	COG1289	transmembrane transporter activity
HB366_RS03260	COG2814	Major facilitator Superfamily
HB366_RS03280	COG1115	amino acid carrier protein
HB366_RS03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB366_RS03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB366_RS03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB366_RS03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB366_RS03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB366_RS03350	COG1077	Cell shape determining protein MreB Mrl
HB366_RS03355	COG1792	Involved in formation and maintenance of cell shape
HB366_RS03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB366_RS03365	COG0424	maF-like protein
HB366_RS03370	COG1530	ribonuclease E activity
HB366_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_RS03390	COG0560	Phosphoserine phosphatase
HB366_RS03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_RS03425	COG2207	Transcriptional regulator
HB366_RS03445	COG1113	amino acid transport
HB366_RS03450	COG2828	Protein conserved in bacteria
HB366_RS03455	COG0142	geranyltranstransferase activity
HB366_RS03460	COG2315	Protein conserved in bacteria
HB366_RS03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB366_RS03495	COG2194	sulfuric ester hydrolase activity
HB366_RS03500	COG0745	RESPONSE REGULATOR receiver
HB366_RS03505	COG0642	Histidine kinase
HB366_RS03515	COG0004	ammonium transporteR
HB366_RS03520	COG0583	DNA-binding transcription factor activity
HB366_RS03540	COG0525	valine-tRNA ligase activity
HB366_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS03560	COG0393	Putative heavy-metal-binding
HB366_RS03565	COG0393	Putative heavy-metal-binding
HB366_RS03570	COG1538	Outer membrane efflux protein
HB366_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS03585	COG0671	phosphoesterase, PA-phosphatase related
HB366_RS03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB366_RS03630	COG1648	precorrin-2 dehydrogenase activity
HB366_RS03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB366_RS03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB366_RS03640	COG1733	regulation of RNA biosynthetic process
HB366_RS03650	COG0531	amino acid
HB366_RS03665	COG0321	lipoyl(octanoyl) transferase activity
HB366_RS03670	COG2921	Belongs to the UPF0250 family
HB366_RS03710	COG2009	succinate dehydrogenase
HB366_RS03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB366_RS03720	COG1053	succinate dehydrogenase
HB366_RS03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB366_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_RS03770	COG2354	Protein conserved in bacteria
HB366_RS03775	COG2321	neutral zinc metallopeptidase
HB366_RS03815	COG2843	Capsule synthesis protein
HB366_RS03830	COG0589	response to stress
HB366_RS03850	COG0505	Belongs to the CarA family
HB366_RS03875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB366_RS03880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB366_RS03930	COG0477	Major facilitator Superfamily
HB366_RS03935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB366_RS03950	COG1597	lipid kinase activity
HB366_RS03955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB366_RS03985	COG0584	glycerophosphoryl diester phosphodiesterase
HB366_RS04005	COG0741	lytic transglycosylase activity
HB366_RS04025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB366_RS04040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_RS04065	COG0778	Nitroreductase
HB366_RS04080	COG1929	Belongs to the glycerate kinase type-1 family
HB366_RS04085	COG0243	molybdopterin cofactor binding
HB366_RS04090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB366_RS04095	COG3339	Conserved Protein
HB366_RS04105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB366_RS04120	COG1113	amino acid transport
HB366_RS04130	COG0019	diaminopimelate decarboxylase activity
HB366_RS04140	COG1280	lysine exporter protein (LysE YggA)
HB366_RS04145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB366_RS04175	COG0463	Glycosyl transferase, family 2
HB366_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS04230	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB366_RS04235	COG1136	(ABC) transporter
HB366_RS04240	COG0658	competence protein
HB366_RS04240	COG2333	competence protein COMEC
HB366_RS04250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB366_RS04250	COG0616	signal peptide processing
HB366_RS04255	COG0596	Alpha beta hydrolase
HB366_RS04260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB366_RS04270	COG0628	permease
HB366_RS04315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB366_RS04335	COG0823	Involved in the tonB-independent uptake of proteins
HB366_RS04355	COG0824	Thioesterase
HB366_RS04360	COG1473	amidohydrolase
HB366_RS04380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB366_RS04380	COG0047	phosphoribosylformylglycinamidine synthase activity
HB366_RS04385	COG2814	Major facilitator Superfamily
HB366_RS04395	COG1024	Enoyl-CoA hydratase
HB366_RS04400	COG1051	belongs to the nudix hydrolase family
HB366_RS04400	COG1056	cytidyltransferase-related domain
HB366_RS04410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB366_RS04425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB366_RS04440	COG4625	pathogenesis
HB366_RS04445	COG0583	DNA-binding transcription factor activity
HB366_RS04450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB366_RS04455	COG4208	sulfate ABC transporter
HB366_RS04460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB366_RS04470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB366_RS04475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB366_RS04480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB366_RS04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB366_RS04515	COG0681	Belongs to the peptidase S26 family
HB366_RS04530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB366_RS04540	COG1381	Involved in DNA repair and RecF pathway recombination
HB366_RS04545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB366_RS04555	COG4221	oxidoreductase activity
HB366_RS04585	COG0436	Aminotransferase
HB366_RS04605	COG0556	nucleotide-excision repair
HB366_RS04660	COG2070	2-Nitropropane dioxygenase
HB366_RS04690	COG1215	transferase activity, transferring glycosyl groups
HB366_RS04705	COG0415	Belongs to the DNA photolyase family
HB366_RS04715	COG1252	NADH dehydrogenase
HB366_RS04720	COG1686	Belongs to the peptidase S11 family
HB366_RS04735	COG1187	pseudouridine synthase activity
HB366_RS04760	COG0477	Major facilitator Superfamily
HB366_RS04765	COG0583	DNA-binding transcription factor activity
HB366_RS04780	COG0612	Peptidase, M16
HB366_RS04805	COG0352	thiamine-phosphate diphosphorylase activity
HB366_RS04840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_RS04855	COG1309	transcriptional regulator
HB366_RS04865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB366_RS04870	COG0076	glutamate decarboxylase activity
HB366_RS04880	COG1522	sequence-specific DNA binding
HB366_RS04885	COG3961	Belongs to the TPP enzyme family
HB366_RS04890	COG1113	amino acid transport
HB366_RS04895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB366_RS04900	COG0573	inorganic phosphate transmembrane transporter activity
HB366_RS04910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB366_RS04915	COG0616	signal peptide processing
HB366_RS04925	COG3328	transposase activity
HB366_RS04955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB366_RS04960	COG1686	Belongs to the peptidase S11 family
HB366_RS04985	COG0583	DNA-binding transcription factor activity
HB366_RS04990	COG1067	ATP-dependent peptidase activity
HB366_RS05035	COG1966	Carbon starvation protein
HB366_RS05040	COG2879	small protein
HB366_RS05075	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HB366_RS05075	COG2508	Transcriptional regulator
HB366_RS05095	COG1113	amino acid transport
HB366_RS05100	COG0583	DNA-binding transcription factor activity
HB366_RS05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_RS05110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_RS05120	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS05125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_RS05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_RS05130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HB366_RS05165	COG2814	Major facilitator Superfamily
HB366_RS05170	COG4948	Mandelate Racemase Muconate Lactonizing
HB366_RS05180	COG1309	transcriptional regulator
HB366_RS05200	COG1741	Belongs to the pirin family
HB366_RS05210	COG2964	Protein conserved in bacteria
HB366_RS05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_RS05230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB366_RS05235	COG4605	iron ion homeostasis
HB366_RS05240	COG4604	ABC transporter, ATP-binding protein
HB366_RS05245	COG4607	ABC-type enterochelin transport system periplasmic component
HB366_RS05250	COG4774	siderophore transport
HB366_RS05260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB366_RS05265	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB366_RS05270	COG3433	isochorismatase activity
HB366_RS05270	COG1535	isochorismatase
HB366_RS05285	COG1132	(ABC) transporter
HB366_RS05295	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB366_RS05305	COG1169	isochorismate synthase
HB366_RS05365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB366_RS05395	COG0308	aminopeptidase N
HB366_RS05400	COG0512	Glutamine amidotransferase of anthranilate synthase
HB366_RS05410	COG3104	oligopeptide transport
HB366_RS05415	COG0174	glutamine synthetase
HB366_RS05425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB366_RS05460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB366_RS05465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB366_RS05470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB366_RS05490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB366_RS05495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB366_RS05500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB366_RS05515	COG1960	acyl-CoA dehydrogenase activity
HB366_RS05520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB366_RS05525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_RS05535	COG2223	nitrite transmembrane transporter activity
HB366_RS05545	COG0024	Methionine aminopeptidase
HB366_RS05550	COG0052	Belongs to the universal ribosomal protein uS2 family
HB366_RS05565	COG2207	Transcriptional regulator
HB366_RS05590	COG2951	lytic endotransglycosylase activity
HB366_RS05595	COG0772	Belongs to the SEDS family
HB366_RS05620	COG0842	Transport permease protein
HB366_RS05625	COG1131	(ABC) transporter
HB366_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS05685	COG4215	(ABC) transporter
HB366_RS05690	COG4160	amino acid transport
HB366_RS05695	COG4598	ABC transporter
HB366_RS05705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB366_RS05715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_RS05730	COG1720	tRNA m6t6A37 methyltransferase activity
HB366_RS05750	COG0745	RESPONSE REGULATOR receiver
HB366_RS05755	COG0642	Histidine kinase
HB366_RS05765	COG0494	nUDIX hydrolase
HB366_RS05775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB366_RS05780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB366_RS05785	COG3139	Protein of unknown function (DUF1315)
HB366_RS05790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB366_RS05795	COG1301	dicarboxylic acid transport
HB366_RS05800	COG1960	acyl-CoA dehydrogenase activity
HB366_RS05805	COG2819	hydrolase of the alpha beta superfamily
HB366_RS05815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB366_RS05825	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB366_RS05830	COG1234	tRNA 3'-trailer cleavage
HB366_RS05860	COG2363	Small membrane protein
HB366_RS05880	COG0513	Belongs to the DEAD box helicase family
HB366_RS05890	COG0778	Nitroreductase
HB366_RS05920	COG1286	toxin biosynthetic process
HB366_RS05945	COG4783	chaperone-mediated protein folding
HB366_RS05950	COG1610	YqeY-like protein
HB366_RS06050	COG3111	PFAM Bacterial OB fold (BOF) protein
HB366_RS06075	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB366_RS06080	COG0786	glutamate:sodium symporter activity
HB366_RS06090	COG2186	Transcriptional regulator
HB366_RS06140	COG0477	Major facilitator Superfamily
HB366_RS06165	COG2985	domain, Protein
HB366_RS06175	COG2995	paraquat-inducible protein a
HB366_RS06180	COG3008	intermembrane lipid transfer
HB366_RS06180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB366_RS06200	COG0482	sulfurtransferase activity
HB366_RS06220	COG3173	Aminoglycoside phosphotransferase
HB366_RS06240	COG1301	dicarboxylic acid transport
HB366_RS06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_RS06255	COG2011	ABC-type metal ion transport system permease component
HB366_RS06260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB366_RS06265	COG1464	Belongs to the NlpA lipoprotein family
HB366_RS06270	COG0151	Belongs to the GarS family
HB366_RS06275	COG0138	bifunctional purine biosynthesis protein purh
HB366_RS06280	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB366_RS06310	COG2308	Evidence 4 Homologs of previously reported genes of
HB366_RS06320	COG1305	Transglutaminase-like
HB366_RS06330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB366_RS06335	COG0305	Participates in initiation and elongation during chromosome replication
HB366_RS06360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB366_RS06370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB366_RS06375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB366_RS06400	COG1649	PFAM Uncharacterised BCR, COG1649
HB366_RS06400	COG0726	polysaccharide deacetylase
HB366_RS06405	COG1215	transferase activity, transferring glycosyl groups
HB366_RS06410	COG3658	cytochrome
HB366_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_RS06435	COG0583	DNA-binding transcription factor activity
HB366_RS06455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_RS06460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_RS06475	COG1960	acyl-CoA dehydrogenase activity
HB366_RS06480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_RS06485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_RS06510	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB366_RS06515	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB366_RS06525	COG2205	protein histidine kinase activity
HB366_RS06530	COG0745	RESPONSE REGULATOR receiver
HB366_RS06535	COG0174	glutamine synthetase
HB366_RS06555	COG0729	surface antigen
HB366_RS06580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB366_RS06585	COG2814	Major facilitator Superfamily
HB366_RS06600	COG0583	DNA-binding transcription factor activity
HB366_RS06615	COG1187	pseudouridine synthase activity
HB366_RS06635	COG0802	atpase or kinase
HB366_RS06640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB366_RS06650	COG1923	regulation of RNA biosynthetic process
HB366_RS06655	COG0697	spore germination
HB366_RS06670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_RS06680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB366_RS06685	COG0519	Catalyzes the synthesis of GMP from XMP
HB366_RS06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB366_RS06690	COG4302	ethanolamine ammonia-lyase activity
HB366_RS06695	COG4303	Ethanolamine ammonia lyase large subunit
HB366_RS06700	COG0531	amino acid
HB366_RS06720	COG1454	alcohol dehydrogenase
HB366_RS06725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB366_RS06735	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HB366_RS06755	COG0308	aminopeptidase N
HB366_RS06785	COG1605	Chorismate mutase
HB366_RS06800	COG1309	transcriptional regulator
HB366_RS06810	COG0668	transmembrane transport
HB366_RS06845	COG4773	Receptor
HB366_RS06865	COG0488	(ABC) transporter
HB366_RS06870	COG0589	response to stress
HB366_RS06895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB366_RS06905	COG3135	benzoate transporter
HB366_RS06910	COG1522	sequence-specific DNA binding
HB366_RS06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB366_RS06925	COG0583	DNA-binding transcription factor activity
HB366_RS06935	COG0183	Belongs to the thiolase family
HB366_RS06945	COG2030	dehydratase
HB366_RS06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB366_RS06975	COG0824	Thioesterase
HB366_RS06980	COG1454	alcohol dehydrogenase
HB366_RS06990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB366_RS07010	COG0069	glutamate synthase activity
HB366_RS07175	COG5410	chromosome segregation
HB366_RS07295	COG0739	heme binding
HB366_RS07360	COG2814	Major facilitator Superfamily
HB366_RS07375	COG0511	ligase activity, forming carbon-carbon bonds
HB366_RS07395	COG1116	anion transmembrane transporter activity
HB366_RS07395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_RS07400	COG0745	RESPONSE REGULATOR receiver
HB366_RS07410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_RS07410	COG2146	nitrite reductase [NAD(P)H] activity
HB366_RS07415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_RS07420	COG0243	molybdopterin cofactor binding
HB366_RS07430	COG0243	molybdopterin cofactor binding
HB366_RS07435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB366_RS07450	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB366_RS07450	COG0315	cyclic pyranopterin monophosphate synthase activity
HB366_RS07455	COG0303	'Molybdopterin
HB366_RS07465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_RS07470	COG0697	spore germination
HB366_RS07490	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB366_RS07495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB366_RS07560	COG2204	response regulator
HB366_RS07565	COG3852	Histidine kinase
HB366_RS07585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB366_RS07590	COG0575	Belongs to the CDS family
HB366_RS07625	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_RS07640	COG2137	regulation of response to DNA damage stimulus
HB366_RS07650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB366_RS07655	COG1011	Hydrolase
HB366_RS07680	COG1522	sequence-specific DNA binding
HB366_RS07690	COG1113	amino acid transport
HB366_RS07705	COG0659	secondary active sulfate transmembrane transporter activity
HB366_RS07710	COG2135	peptidase activity
HB366_RS07725	COG5001	Diguanylate cyclase
HB366_RS07725	COG3300	MHYT domain
HB366_RS07745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB366_RS07745	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB366_RS07745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB366_RS07750	COG1105	Belongs to the carbohydrate kinase PfkB family
HB366_RS07755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB366_RS07755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB366_RS07785	COG0024	Methionine aminopeptidase
HB366_RS07790	COG0583	DNA-binding transcription factor activity
HB366_RS07800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB366_RS07805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB366_RS07810	COG0517	IMP dehydrogenase activity
HB366_RS07810	COG0516	GMP reductase activity
HB366_RS07835	COG0552	protein localization to endoplasmic reticulum
HB366_RS07845	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB366_RS07860	COG4890	Cyd operon protein YbgT
HB366_RS07865	COG1294	oxidase, subunit
HB366_RS07880	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB366_RS07890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB366_RS07895	COG4774	siderophore transport
HB366_RS07910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB366_RS07915	COG0569	domain protein
HB366_RS07920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB366_RS07950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB366_RS07955	COG0542	response to heat
HB366_RS07980	COG1902	pentaerythritol trinitrate reductase activity
HB366_RS07980	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_RS08025	COG2323	membrane
HB366_RS08030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB366_RS08040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_RS08045	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_RS08050	COG0183	Belongs to the thiolase family
HB366_RS08055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB366_RS08060	COG0596	Alpha beta hydrolase
HB366_RS08065	COG2271	Major facilitator Superfamily
HB366_RS08070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB366_RS08075	COG3485	protocatechuate 3,4-dioxygenase
HB366_RS08080	COG3485	protocatechuate 3,4-dioxygenase
HB366_RS08085	COG0710	3-dehydroquinate dehydratase activity
HB366_RS08090	COG3420	alginic acid biosynthetic process
HB366_RS08095	COG3659	wide pore channel activity
HB366_RS08100	COG4993	Dehydrogenase
HB366_RS08110	COG2391	methyltransferase activity
HB366_RS08125	COG1414	Transcriptional regulator
HB366_RS08130	COG0583	DNA-binding transcription factor activity
HB366_RS08135	COG1960	acyl-CoA dehydrogenase activity
HB366_RS08160	COG2814	Major facilitator Superfamily
HB366_RS08170	COG0154	amidase activity
HB366_RS08190	COG4638	Rieske (2fe-2S)
HB366_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS08210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_RS08220	COG3733	amine oxidase
HB366_RS08230	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS08240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_RS08245	COG0183	Belongs to the thiolase family
HB366_RS08250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_RS08255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_RS08265	COG4829	muconolactone delta-isomerase
HB366_RS08270	COG4948	Mandelate Racemase Muconate Lactonizing
HB366_RS08275	COG0583	DNA-binding transcription factor activity
HB366_RS08285	COG2186	Transcriptional regulator
HB366_RS08305	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS08325	COG1960	acyl-CoA dehydrogenase activity
HB366_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS08335	COG3829	transcription factor binding
HB366_RS08345	COG3162	membrane
HB366_RS08360	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS08375	COG0753	catalase activity
HB366_RS08395	COG1846	Transcriptional regulator
HB366_RS08400	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_RS08400	COG1902	pentaerythritol trinitrate reductase activity
HB366_RS08410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB366_RS08440	COG1309	transcriptional regulator
HB366_RS08450	COG1335	isochorismatase
HB366_RS08455	COG0583	DNA-binding transcription factor activity
HB366_RS08465	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_RS08465	COG0475	glutathione-regulated potassium exporter activity
HB366_RS08475	COG1473	amidohydrolase
HB366_RS08485	COG2831	hemolysin activation secretion protein
HB366_RS08490	COG3210	domain, Protein
HB366_RS08520	COG2188	Transcriptional regulator
HB366_RS08535	COG0583	DNA-binding transcription factor activity
HB366_RS08565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB366_RS08585	COG1566	PFAM secretion protein HlyD family protein
HB366_RS08600	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS08605	COG0129	dihydroxy-acid dehydratase activity
HB366_RS08615	COG0583	DNA-binding transcription factor activity
HB366_RS08620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB366_RS08630	COG2084	Dehydrogenase
HB366_RS08635	COG2207	Transcriptional regulator
HB366_RS08650	COG1064	alcohol dehydrogenase
HB366_RS08665	COG1120	ATPase activity
HB366_RS08685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB366_RS08800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB366_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS08865	COG2207	Transcriptional regulator
HB366_RS08875	COG2205	protein histidine kinase activity
HB366_RS08880	COG0745	RESPONSE REGULATOR receiver
HB366_RS08885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS08890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB366_RS08895	COG1538	Outer membrane efflux protein
HB366_RS08905	COG2072	flavoprotein involved in K transport
HB366_RS08925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_RS08945	COG3539	Fimbrial protein
HB366_RS08975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB366_RS08985	COG0753	catalase activity
HB366_RS09000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB366_RS09065	COG1535	isochorismatase
HB366_RS09065	COG3433	isochorismatase activity
HB366_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS09075	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB366_RS09080	COG4149	molybdate abc transporter
HB366_RS09085	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB366_RS09095	COG4638	Rieske (2fe-2S)
HB366_RS09100	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB366_RS09105	COG0543	2 iron, 2 sulfur cluster binding
HB366_RS09105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS09145	COG2207	Transcriptional regulator
HB366_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS09160	COG2610	gluconate transmembrane transporter activity
HB366_RS09170	COG0583	DNA-binding transcription factor activity
HB366_RS09180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_RS09185	COG2031	fatty acid transporter
HB366_RS09190	COG0183	Belongs to the thiolase family
HB366_RS09195	COG0583	DNA-binding transcription factor activity
HB366_RS09200	COG0583	DNA-binding transcription factor activity
HB366_RS09215	COG1027	Aspartate ammonia-lyase
HB366_RS09225	COG0477	Major facilitator Superfamily
HB366_RS09245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_RS09250	COG4521	taurine ABC transporter
HB366_RS09265	COG2188	Transcriptional regulator
HB366_RS09275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB366_RS09280	COG1733	regulation of RNA biosynthetic process
HB366_RS09285	COG3708	Transcriptional regulator
HB366_RS09285	COG2207	Transcriptional regulator
HB366_RS09300	COG0730	response to heat
HB366_RS09310	COG3453	Protein conserved in bacteria
HB366_RS09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_RS09320	COG3781	membrane
HB366_RS09325	COG1063	alcohol dehydrogenase
HB366_RS09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB366_RS09340	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB366_RS09345	COG0022	dehydrogenase e1 component
HB366_RS09350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB366_RS09355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB366_RS09370	COG3706	GGDEF domain
HB366_RS09385	COG0133	tryptophan synthase activity
HB366_RS09395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB366_RS09430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB366_RS09455	COG2226	methyltransferase
HB366_RS09510	COG0842	Transport permease protein
HB366_RS09515	COG0842	Transport permease protein
HB366_RS09520	COG1131	(ABC) transporter
HB366_RS09535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB366_RS09540	COG4773	Receptor
HB366_RS09560	COG0730	response to heat
HB366_RS09565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB366_RS09585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB366_RS09640	COG4264	IucA IucC family
HB366_RS09645	COG4264	IucA IucC family
HB366_RS09665	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB366_RS09680	COG1960	acyl-CoA dehydrogenase activity
HB366_RS09685	COG1960	acyl-CoA dehydrogenase activity
HB366_RS09690	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB366_RS09695	COG2207	Transcriptional regulator
HB366_RS09700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB366_RS09705	COG0776	regulation of translation
HB366_RS09730	COG0822	iron-sulfur transferase activity
HB366_RS09735	COG0316	Belongs to the HesB IscA family
HB366_RS09765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB366_RS09785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB366_RS09790	COG0702	epimerase
HB366_RS09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HB366_RS09835	COG0339	signal peptide processing
HB366_RS09885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB366_RS09890	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB366_RS09920	COG0776	regulation of translation
HB366_RS09985	COG0084	hydrolase, TatD family'
HB366_RS10005	COG1663	tetraacyldisaccharide 4'-kinase activity
HB366_RS10010	COG1132	(ABC) transporter
HB366_RS10020	COG0811	peptide transport
HB366_RS10025	COG1475	DNA binding
HB366_RS10030	COG1192	Involved in chromosome partitioning
HB366_RS10040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB366_RS10055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB366_RS10060	COG0191	fructose-bisphosphate aldolase activity
HB366_RS10080	COG0424	maF-like protein
HB366_RS10085	COG2850	peptidyl-arginine hydroxylation
HB366_RS10095	COG0640	Transcriptional regulator
HB366_RS10110	COG3619	membrane
HB366_RS10115	COG3122	Protein conserved in bacteria
HB366_RS10120	COG1132	(ABC) transporter
HB366_RS10140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB366_RS10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB366_RS10155	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB366_RS10155	COG0506	proline dehydrogenase activity
HB366_RS10155	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB366_RS10160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB366_RS10175	COG3698	Phosphodiester glycosidase
HB366_RS10185	COG2353	YceI-like domain
HB366_RS10195	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB366_RS10240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB366_RS10240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB366_RS10265	COG3539	Fimbrial protein
HB366_RS10270	COG3121	Chaperone
HB366_RS10295	COG0697	spore germination
HB366_RS10305	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB366_RS10315	COG0583	DNA-binding transcription factor activity
HB366_RS10335	COG1309	transcriptional regulator
HB366_RS10350	COG1522	sequence-specific DNA binding
HB366_RS10360	COG1126	abc transporter atp-binding protein
HB366_RS10365	COG0765	amino acid transport
HB366_RS10370	COG0765	amino acid transport
HB366_RS10400	COG1464	Belongs to the NlpA lipoprotein family
HB366_RS10410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB366_RS10415	COG2011	ABC-type metal ion transport system permease component
HB366_RS10420	COG0012	GTP binding
HB366_RS10445	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB366_RS10485	COG0386	Belongs to the glutathione peroxidase family
HB366_RS10495	COG0436	Aminotransferase
HB366_RS10535	COG3634	alkyl hydroperoxide reductase activity
HB366_RS10550	COG0583	DNA-binding transcription factor activity
HB366_RS10555	COG0798	PFAM Bile acid sodium symporter
HB366_RS10560	COG0640	Transcriptional regulator
HB366_RS10575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB366_RS10585	COG0583	DNA-binding transcription factor activity
HB366_RS10595	COG1953	Uracil, thiamine, allantoin
HB366_RS10605	COG2175	clavaminate synthase activity
HB366_RS10610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_RS10615	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB366_RS10620	COG4521	taurine ABC transporter
HB366_RS10630	COG0477	Major facilitator Superfamily
HB366_RS10650	COG1271	oxidase subunit
HB366_RS10655	COG1294	oxidase, subunit
HB366_RS10665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB366_RS10685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB366_RS10705	COG3052	prosthetic group binding
HB366_RS10710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB366_RS10720	COG2814	Major facilitator Superfamily
HB366_RS10740	COG1346	cytolysis
HB366_RS10750	COG0583	DNA-binding transcription factor activity
HB366_RS10755	COG0625	glutathione transferase activity
HB366_RS10760	COG0625	glutathione transferase activity
HB366_RS10765	COG0583	DNA-binding transcription factor activity
HB366_RS10780	COG1045	serine acetyltransferase
HB366_RS10785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB366_RS10790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB366_RS10800	COG1280	lysine exporter protein (LysE YggA)
HB366_RS10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_RS10820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_RS10825	COG1126	abc transporter atp-binding protein
HB366_RS10830	COG0765	amino acid transport
HB366_RS10835	COG0765	amino acid transport
HB366_RS10855	COG2205	protein histidine kinase activity
HB366_RS10855	COG0784	Response regulator, receiver
HB366_RS10875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB366_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS10945	COG0583	DNA-binding transcription factor activity
HB366_RS10965	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_RS10970	COG1309	transcriptional regulator
HB366_RS10975	COG1960	acyl-CoA dehydrogenase activity
HB366_RS10980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB366_RS10985	COG1024	Enoyl-CoA hydratase
HB366_RS10990	COG4770	biotin carboxylase activity
HB366_RS11000	COG0583	DNA-binding transcription factor activity
HB366_RS11015	COG1960	acyl-CoA dehydrogenase activity
HB366_RS11025	COG2814	Major facilitator Superfamily
HB366_RS11035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB366_RS11040	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB366_RS11045	COG2814	Major facilitator Superfamily
HB366_RS11050	COG1960	acyl-CoA dehydrogenase activity
HB366_RS11055	COG1024	Enoyl-CoA hydratase
HB366_RS11060	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS11065	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_RS11070	COG0183	Belongs to the thiolase family
HB366_RS11080	COG2814	Major facilitator Superfamily
HB366_RS11090	COG1024	Enoyl-CoA hydratase
HB366_RS11105	COG1960	acyl-CoA dehydrogenase activity
HB366_RS11110	COG2814	Major facilitator Superfamily
HB366_RS11115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB366_RS11120	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB366_RS11135	COG3842	ATPase activity
HB366_RS11140	COG1840	ABC-type Fe3 transport system, periplasmic component
HB366_RS11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_RS11155	COG1414	Transcriptional regulator
HB366_RS11165	COG0583	DNA-binding transcription factor activity
HB366_RS11170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB366_RS11175	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS11185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB366_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS11200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_RS11205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_RS11210	COG2267	carboxylic ester hydrolase activity
HB366_RS11230	COG3038	cytochrome b561
HB366_RS11235	COG0753	catalase activity
HB366_RS11270	COG2050	protein possibly involved in aromatic compounds catabolism
HB366_RS11280	COG3327	negative regulation of DNA-templated transcription, initiation
HB366_RS11285	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB366_RS11290	COG0183	Belongs to the thiolase family
HB366_RS11295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_RS11300	COG1024	Enoyl-CoA hydratase
HB366_RS11305	COG1024	Enoyl-CoA hydratase
HB366_RS11310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB366_RS11315	COG2151	metal-sulfur cluster biosynthetic enzyme
HB366_RS11320	COG3396	Phenylacetate-CoA oxygenase
HB366_RS11325	COG3460	Phenylacetate-CoA oxygenase
HB366_RS11330	COG3396	Phenylacetate-CoA oxygenase
HB366_RS11335	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS11335	COG2030	dehydratase
HB366_RS11340	COG1760	l-serine dehydratase
HB366_RS11345	COG0531	amino acid
HB366_RS11350	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS11365	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_RS11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB366_RS11395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_RS11405	COG0789	Transcriptional regulator
HB366_RS11420	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB366_RS11435	COG2807	transmembrane transport
HB366_RS11440	COG0590	tRNA wobble adenosine to inosine editing
HB366_RS11555	COG1116	anion transmembrane transporter activity
HB366_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB366_RS11570	COG0864	Transcriptional regulator
HB366_RS11590	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB366_RS11595	COG0439	Biotin carboxylase
HB366_RS11610	COG1063	alcohol dehydrogenase
HB366_RS11620	COG1309	transcriptional regulator
HB366_RS11640	COG0038	chloride channel
HB366_RS11645	COG4770	biotin carboxylase activity
HB366_RS11665	COG1914	H( )-stimulated, divalent metal cation uptake system
HB366_RS11670	COG0583	DNA-binding transcription factor activity
HB366_RS11685	COG3209	COG3209 Rhs family protein
HB366_RS11690	COG3501	Rhs element vgr protein
HB366_RS11720	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB366_RS11740	COG2814	Major facilitator Superfamily
HB366_RS11750	COG1560	Kdo2-lipid A biosynthetic process
HB366_RS11760	COG5006	permease, DMT superfamily
HB366_RS11765	COG1522	sequence-specific DNA binding
HB366_RS11780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB366_RS11790	COG4122	O-methyltransferase activity
HB366_RS11820	COG1538	Outer membrane efflux protein
HB366_RS11830	COG1137	ATPase activity
HB366_RS11835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB366_RS11845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB366_RS11850	COG0517	IMP dehydrogenase activity
HB366_RS11850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HB366_RS11980	COG3566	protein conserved in bacteria
HB366_RS12000	COG3567	Phage-associated protein, HI1409 family
HB366_RS12005	COG5410	chromosome segregation
HB366_RS12090	COG4197	protein conserved in bacteria, prophage-related
HB366_RS12095	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB366_RS12170	COG2814	Major facilitator Superfamily
HB366_RS12205	COG1278	Cold shock
HB366_RS12210	COG1280	lysine exporter protein (LysE YggA)
HB366_RS12245	COG1570	exodeoxyribonuclease VII activity
HB366_RS12295	COG0583	DNA-binding transcription factor activity
HB366_RS12300	COG4638	Rieske (2fe-2S)
HB366_RS12305	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB366_RS12310	COG0543	2 iron, 2 sulfur cluster binding
HB366_RS12310	COG0633	Ferredoxin
HB366_RS12315	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS12320	COG3135	benzoate transporter
HB366_RS12325	COG2814	Major facilitator Superfamily
HB366_RS12340	COG1643	Atp-dependent helicase
HB366_RS12345	COG0450	alkyl hydroperoxide reductase
HB366_RS12355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB366_RS12365	COG3634	alkyl hydroperoxide reductase activity
HB366_RS12385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB366_RS12390	COG0625	glutathione transferase activity
HB366_RS12400	COG2885	chlorophyll binding
HB366_RS12435	COG0542	response to heat
HB366_RS12450	COG1765	OsmC-like protein
HB366_RS12465	COG0667	Aldo Keto reductase
HB366_RS12480	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB366_RS12490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB366_RS12500	COG0527	aspartate kinase activity
HB366_RS12510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB366_RS12520	COG3038	cytochrome b561
HB366_RS12525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB366_RS12530	COG2252	PERMEase
HB366_RS12540	COG2072	flavoprotein involved in K transport
HB366_RS12555	COG1741	Belongs to the pirin family
HB366_RS12560	COG1309	transcriptional regulator
HB366_RS12580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_RS12580	COG1902	pentaerythritol trinitrate reductase activity
HB366_RS12590	COG5001	Diguanylate cyclase
HB366_RS12590	COG4251	negative regulation of phosphorylation
HB366_RS12590	COG3706	GGDEF domain
HB366_RS12590	COG2203	Gaf domain
HB366_RS12600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_RS12620	COG4172	Belongs to the ABC transporter superfamily
HB366_RS12625	COG4239	(ABC) transporter, permease
HB366_RS12630	COG4174	ABC transporter (Permease)
HB366_RS12640	COG1388	LysM domain
HB366_RS12640	COG0741	lytic transglycosylase activity
HB366_RS12640	COG0741	lytic transglycosylase activity
HB366_RS12640	COG1388	LysM domain
HB366_RS12645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_RS12685	COG0583	DNA-binding transcription factor activity
HB366_RS12690	COG1279	arginine transmembrane transporter activity
HB366_RS12710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_RS12715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_RS12720	COG0006	proline dipeptidase activity
HB366_RS12755	COG2194	sulfuric ester hydrolase activity
HB366_RS12800	COG0739	heme binding
HB366_RS13125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB366_RS13150	COG3384	dioxygenase
HB366_RS13160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB366_RS13165	COG2878	Part of a membrane complex involved in electron transport
HB366_RS13170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB366_RS13195	COG0768	penicillin binding
HB366_RS13200	COG0742	ribosomal rna small subunit methyltransferase
HB366_RS13215	COG0830	nickel cation binding
HB366_RS13225	COG0804	urea catabolic process
HB366_RS13265	COG1253	flavin adenine dinucleotide binding
HB366_RS13270	COG2851	Citrate transporter
HB366_RS13325	COG1773	rubredoxin
HB366_RS13330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB366_RS13340	COG0583	DNA-binding transcription factor activity
HB366_RS13365	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB366_RS13370	COG4181	ATPase activity
HB366_RS13415	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB366_RS13435	COG0306	phosphate transporter
HB366_RS13445	COG3958	Transketolase
HB366_RS13450	COG3959	Transketolase, thiamine diphosphate binding domain
HB366_RS13455	COG2271	Major facilitator Superfamily
HB366_RS13460	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS13465	COG0583	DNA-binding transcription factor activity
HB366_RS13480	COG2223	nitrite transmembrane transporter activity
HB366_RS13485	COG2207	Transcriptional regulator
HB366_RS13490	COG2066	Belongs to the glutaminase family
HB366_RS13495	COG0242	peptide deformylase activity
HB366_RS13500	COG0477	Major facilitator Superfamily
HB366_RS13510	COG0028	Belongs to the TPP enzyme family
HB366_RS13525	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS13530	COG2267	carboxylic ester hydrolase activity
HB366_RS13540	COG2271	Major facilitator Superfamily
HB366_RS13545	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB366_RS13555	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS13575	COG1414	Transcriptional regulator
HB366_RS13590	COG1024	Enoyl-CoA hydratase
HB366_RS13600	COG1215	transferase activity, transferring glycosyl groups
HB366_RS13605	COG0726	polysaccharide deacetylase
HB366_RS13605	COG1649	PFAM Uncharacterised BCR, COG1649
HB366_RS13615	COG4681	YaeQ
HB366_RS13625	COG0523	cobalamin synthesis protein
HB366_RS13635	COG1607	acyl-coa hydrolase
HB366_RS13645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_RS13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB366_RS13655	COG1309	transcriptional regulator
HB366_RS13680	COG2040	homocysteine
HB366_RS13685	COG0531	amino acid
HB366_RS13740	COG1595	DNA-templated transcription, initiation
HB366_RS13750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_RS13755	COG0477	Major facilitator Superfamily
HB366_RS13775	COG0084	hydrolase, TatD family'
HB366_RS13810	COG0629	single-stranded DNA binding
HB366_RS13865	COG0582	viral genome integration into host DNA
HB366_RS13960	COG0592	DNA-directed DNA polymerase activity
HB366_RS14000	COG2026	Addiction module toxin, RelE StbE family
HB366_RS14235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB366_RS14305	COG0405	Gamma-glutamyltransferase
HB366_RS14310	COG2814	Major facilitator Superfamily
HB366_RS14320	COG2050	protein possibly involved in aromatic compounds catabolism
HB366_RS14335	COG1090	epimerase
HB366_RS14355	COG0420	3'-5' exonuclease activity
HB366_RS14380	COG0735	belongs to the Fur family
HB366_RS14385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB366_RS14405	COG0121	glutamine amidotransferase
HB366_RS14420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_RS14430	COG0210	DNA helicase
HB366_RS14435	COG2885	chlorophyll binding
HB366_RS14440	COG0204	Acyl-transferase
HB366_RS14455	COG2894	cell division
HB366_RS14480	COG1280	lysine exporter protein (LysE YggA)
HB366_RS14485	COG1674	ftsk spoiiie
HB366_RS14485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB366_RS14490	COG0492	ferredoxin-NADP+ reductase activity
HB366_RS14495	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB366_RS14505	COG0456	acetyltransferase
HB366_RS14565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB366_RS14565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB366_RS14585	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS14605	COG0473	3-isopropylmalate dehydrogenase activity
HB366_RS14610	COG0583	DNA-binding transcription factor activity
HB366_RS14630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB366_RS14655	COG0564	pseudouridine synthase activity
HB366_RS14665	COG0358	DNA primase activity
HB366_RS14680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB366_RS14710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB366_RS14740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB366_RS14750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB366_RS14750	COG0352	thiamine-phosphate diphosphorylase activity
HB366_RS14750	COG0351	phosphomethylpyrimidine kinase
HB366_RS14755	COG1652	LysM domain
HB366_RS14780	COG1399	metal-binding, possibly nucleic acid-binding protein
HB366_RS14785	COG3101	peptidyl-lysine hydroxylation
HB366_RS14790	COG0009	L-threonylcarbamoyladenylate synthase
HB366_RS14795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB366_RS14800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB366_RS14815	COG4106	trans-aconitate 2-methyltransferase activity
HB366_RS14830	COG2226	methyltransferase
HB366_RS14830	COG0596	Alpha beta hydrolase
HB366_RS14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_RS14835	COG1877	trehalose-phosphatase activity
HB366_RS14840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB366_RS14845	COG2223	nitrite transmembrane transporter activity
HB366_RS14865	COG1196	nuclear chromosome segregation
HB366_RS14875	COG0730	response to heat
HB366_RS14890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB366_RS14900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB366_RS14950	COG0489	protein tyrosine kinase activity
HB366_RS14960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_RS14960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_RS14990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB366_RS14995	COG2081	HI0933 family
HB366_RS15005	COG0668	transmembrane transport
HB366_RS15025	COG0583	DNA-binding transcription factor activity
HB366_RS15045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB366_RS15050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB366_RS15080	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB366_RS15115	COG2205	protein histidine kinase activity
HB366_RS15120	COG0745	RESPONSE REGULATOR receiver
HB366_RS15140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB366_RS15150	COG2205	protein histidine kinase activity
HB366_RS15220	COG4993	Dehydrogenase
HB366_RS15240	COG0384	phenazine biosynthesis protein PhzF
HB366_RS15260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB366_RS15275	COG0583	DNA-binding transcription factor activity
HB366_RS15295	COG1473	amidohydrolase
HB366_RS15305	COG0583	DNA-binding transcription factor activity
HB366_RS15320	COG0583	DNA-binding transcription factor activity
HB366_RS15325	COG1053	succinate dehydrogenase
HB366_RS15335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB366_RS15340	COG2814	Major facilitator Superfamily
HB366_RS15345	COG1960	acyl-CoA dehydrogenase activity
HB366_RS15350	COG0583	DNA-binding transcription factor activity
HB366_RS15355	COG1063	alcohol dehydrogenase
HB366_RS15385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB366_RS15390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB366_RS15395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB366_RS15410	COG3667	copper resistance
HB366_RS15415	COG2132	Multicopper oxidase
HB366_RS15425	COG0561	phosphatase activity
HB366_RS15430	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB366_RS15455	COG1214	PFAM Peptidase M22, glycoprotease
HB366_RS15505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB366_RS15515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB366_RS15520	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB366_RS15525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB366_RS15585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB366_RS15595	COG1846	Transcriptional regulator
HB366_RS15600	COG1764	response to oxidative stress
HB366_RS15650	COG0037	tRNA processing
HB366_RS15660	COG0248	Ppx GppA phosphatase
HB366_RS15690	COG0072	phenylalanine-tRNA ligase activity
HB366_RS15730	COG1238	metal cluster binding
HB366_RS15735	COG0625	glutathione transferase activity
HB366_RS15750	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_RS15755	COG3028	Belongs to the UPF0307 family
HB366_RS15760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB366_RS15780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB366_RS15785	COG0617	tRNA 3'-terminal CCA addition
HB366_RS15790	COG1555	photosystem II stabilization
HB366_RS15795	COG3956	TIGRFAM MazG family protein
HB366_RS15805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB366_RS15825	COG5002	protein histidine kinase activity
HB366_RS15825	COG2205	protein histidine kinase activity
HB366_RS15825	COG0784	Response regulator, receiver
HB366_RS15830	COG1024	Enoyl-CoA hydratase
HB366_RS15835	COG2084	Dehydrogenase
HB366_RS15840	COG3622	Belongs to the hyi family
HB366_RS15870	COG0697	spore germination
HB366_RS15880	COG2814	Major facilitator Superfamily
HB366_RS15885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB366_RS15895	COG0583	DNA-binding transcription factor activity
HB366_RS15905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB366_RS15920	COG0084	hydrolase, TatD family'
HB366_RS15935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB366_RS15965	COG0440	acetolactate synthase activity
HB366_RS15970	COG0028	Belongs to the TPP enzyme family
HB366_RS15995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB366_RS16000	COG1136	(ABC) transporter
HB366_RS16000	COG0577	efflux transmembrane transporter activity
HB366_RS16005	COG1538	Outer membrane efflux protein
HB366_RS16020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB366_RS16025	COG1162	GTPase activity
HB366_RS16035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB366_RS16055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HB366_RS16060	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS16100	COG2986	histidine ammonia-lyase
HB366_RS16115	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_RS16125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB366_RS16170	COG1426	Protein conserved in bacteria
HB366_RS16205	COG0793	Belongs to the peptidase S41A family
HB366_RS16220	COG2267	carboxylic ester hydrolase activity
HB366_RS16230	COG1012	belongs to the aldehyde dehydrogenase family
HB366_RS16235	COG3265	gluconokinase activity
HB366_RS16245	COG0800	Aldolase
HB366_RS16260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB366_RS16265	COG0857	belongs to the CobB CobQ family
HB366_RS16265	COG0280	phosphate acetyltransferase
HB366_RS16270	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB366_RS16270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB366_RS16290	COG0740	serine-type endopeptidase activity
HB366_RS16310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB366_RS16320	COG2813	Specifically methylates the guanine in position
HB366_RS16320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB366_RS16420	COG0788	formyltetrahydrofolate deformylase activity
HB366_RS16445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_RS16445	COG4651	solute:proton antiporter activity
HB366_RS16465	COG0724	RNA recognition motif
HB366_RS16470	COG0210	DNA helicase
HB366_RS16495	COG1733	regulation of RNA biosynthetic process
HB366_RS16505	COG2900	Belongs to the SlyX family
HB366_RS16515	COG1280	lysine exporter protein (LysE YggA)
HB366_RS16520	COG1560	Kdo2-lipid A biosynthetic process
HB366_RS16530	COG1301	dicarboxylic acid transport
HB366_RS16585	COG0473	3-isopropylmalate dehydrogenase activity
HB366_RS16650	COG0583	DNA-binding transcription factor activity
HB366_RS16660	COG0625	glutathione transferase activity
HB366_RS16665	COG2378	regulation of single-species biofilm formation
HB366_RS16670	COG0546	phosphoglycolate phosphatase activity
HB366_RS16685	COG1530	ribonuclease E activity
HB366_RS16690	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_RS16705	COG0583	DNA-binding transcription factor activity
HB366_RS16710	COG4221	oxidoreductase activity
HB366_RS16715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB366_RS16725	COG0534	Mate efflux family protein
HB366_RS16740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB366_RS16780	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB366_RS16785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB366_RS16800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB366_RS16810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB366_RS16810	COG0644	oxidoreductase
HB366_RS16815	COG0425	Belongs to the sulfur carrier protein TusA family
HB366_RS16820	COG4535	Mg2 and Co2 transporter CorC
HB366_RS16830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB366_RS16850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB366_RS16855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB366_RS16855	COG0475	glutathione-regulated potassium exporter activity
HB366_RS16860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HB366_RS16870	COG0484	heat shock protein binding
HB366_RS16875	COG0789	Transcriptional regulator
HB366_RS16880	COG0598	Magnesium transport protein CorA
HB366_RS16900	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB366_RS16905	COG1074	ATP-dependent DNA helicase activity
HB366_RS16910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB366_RS16930	COG2226	methyltransferase
HB366_RS16945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB366_RS16950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB366_RS16965	COG2111	Na H antiporter
HB366_RS16965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB366_RS16970	COG1006	Multisubunit Na H antiporter MnhC subunit
HB366_RS16975	COG0651	ATP synthesis coupled electron transport
HB366_RS16985	COG2212	antiporter activity
HB366_RS17005	COG0195	Participates in both transcription termination and antitermination
HB366_RS17055	COG0237	dephospho-CoA kinase activity
HB366_RS17065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB366_RS17080	COG0497	DNA recombination
HB366_RS17090	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB366_RS17120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB366_RS17120	COG2169	Transcriptional regulator
HB366_RS17125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB366_RS17190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB366_RS17205	COG0326	Molecular chaperone. Has ATPase activity
HB366_RS17220	COG2056	Na+-H+ antiporter family
HB366_RS17225	COG0596	Alpha beta hydrolase
HB366_RS17320	COG0546	phosphoglycolate phosphatase activity
HB366_RS17325	COG1716	ATPase activity
HB366_RS17370	COG0181	hydroxymethylbilane synthase activity
HB366_RS17380	COG3275	phosphorelay sensor kinase activity
HB366_RS17400	COG1538	Outer membrane efflux protein
HB366_RS17405	COG0697	spore germination
HB366_RS17430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB366_RS17435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB366_RS17440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB366_RS17445	COG0772	Belongs to the SEDS family
HB366_RS17470	COG4974	Belongs to the 'phage' integrase family
HB366_RS17475	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_RS17485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB366_RS17495	COG2197	response regulator
HB366_RS17510	COG0793	Belongs to the peptidase S41A family
HB366_RS17515	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB366_RS17520	COG0795	lipopolysaccharide-transporting ATPase activity
HB366_RS17560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB366_RS17560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB366_RS17570	COG0004	ammonium transporteR
HB366_RS17575	COG0347	Belongs to the P(II) protein family
HB366_RS17585	COG0606	chelatase, subunit chli
HB366_RS17660	COG1061	Type III restriction enzyme res subunit
HB366_RS17675	COG0659	secondary active sulfate transmembrane transporter activity
HB366_RS17680	COG0589	response to stress
HB366_RS17725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_RS17770	COG1061	Type III restriction enzyme res subunit
HB366_RS17805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB366_RS17835	COG0659	secondary active sulfate transmembrane transporter activity
HB366_RS17840	COG0589	response to stress
HB366_RS17870	COG0606	chelatase, subunit chli
HB366_RS17885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB366_RS17900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB366_RS17915	COG0318	PFAM AMP-dependent synthetase and ligase
HB366_RS17925	COG0477	Major facilitator Superfamily
HB366_RS17930	COG2860	membrane
HB366_RS17940	COG1253	flavin adenine dinucleotide binding
HB366_RS17960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB366_RS17995	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB366_RS18005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB366_RS18040	COG1309	transcriptional regulator
HB366_RS18075	COG0758	DNA mediated transformation
HB366_RS18085	COG0697	spore germination
HB366_RS18090	COG1309	transcriptional regulator
HB366_RS18105	COG0386	Belongs to the glutathione peroxidase family
HB366_RS18170	COG1121	(ABC) transporter
HB366_RS18175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB366_RS18180	COG1280	lysine exporter protein (LysE YggA)
HB366_RS18185	COG2837	iron assimilation
HB366_RS18195	COG0281	malic enzyme
HB366_RS18240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB366_RS18240	COG0519	Catalyzes the synthesis of GMP from XMP
HB366_RS18245	COG4399	Belongs to the UPF0754 family
HB366_RS18250	COG2259	Doxx family
HB366_RS18255	COG0586	Pfam SNARE associated Golgi protein
HB366_RS18270	COG1192	Involved in chromosome partitioning
HB366_RS18280	COG0271	Belongs to the BolA IbaG family
HB366_RS18300	COG2267	carboxylic ester hydrolase activity
HB366_RS18320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HB366_RS18320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HB366_RS18320	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HB366_RS18320	COG3321	synthase
HB366_RS18325	COG1960	acyl-CoA dehydrogenase activity
HB366_RS18335	COG2197	response regulator
HB366_RS18345	COG3916	Acyl-homoserine-lactone synthase
HB366_RS18350	COG0477	Major facilitator Superfamily
HB366_RS18355	COG1024	Enoyl-CoA hydratase
HB366_RS18360	COG1024	Enoyl-CoA hydratase
HB366_RS18365	COG1960	acyl-CoA dehydrogenase activity
HB366_RS18370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB366_RS18390	COG1113	amino acid transport
HB366_RS18395	COG1113	amino acid transport
HB366_RS18400	COG0251	oxidation-reduction process
HB366_RS18440	COG0564	pseudouridine synthase activity
HB366_RS18500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB366_RS18515	COG1802	Transcriptional regulator
HB366_RS18525	COG1448	Aminotransferase
HB366_RS18530	COG0277	FAD linked oxidase domain protein
HB366_RS18540	COG2186	Transcriptional regulator
HB366_RS18550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB366_RS18555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB366_RS18570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB366_RS18575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB366_RS18600	COG0438	transferase activity, transferring glycosyl groups
HB366_RS18630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB366_RS18660	COG0728	peptidoglycan biosynthetic process
HB366_RS18665	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB366_RS18720	COG0546	phosphoglycolate phosphatase activity
HB366_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
HB366_RS18745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_RS18750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB366_RS18755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB366_RS18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB366_RS18765	COG1116	anion transmembrane transporter activity
HB366_RS18770	COG1309	transcriptional regulator
HB366_RS18775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB366_RS18785	COG0196	riboflavin kinase activity
HB366_RS18790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB366_RS18800	COG1047	Peptidyl-prolyl cis-trans
HB366_RS18840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB366_RS18895	COG2951	lytic endotransglycosylase activity
HB366_RS18900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB366_RS18915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB366_RS18925	COG0671	phosphoesterase, PA-phosphatase related
HB366_RS18930	COG0861	Integral membrane protein TerC family
HB366_RS18940	COG0754	glutathionylspermidine amidase activity
HB366_RS18950	COG0402	S-adenosylhomocysteine deaminase activity
HB366_RS18965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_RS18970	COG1230	cation diffusion facilitator family transporter
HB366_RS18985	COG0706	membrane insertase activity
HB366_RS19055	COG1525	nuclease
HB366_RS19115	COG1475	DNA binding
HB366_RS19130	COG3853	Toxic anion resistance protein (TelA)
HB366_RS19215	COG0484	heat shock protein binding
HB366_RS19280	COG2826	transposase and inactivated derivatives, IS30 family
HB366_RS19290	COG2826	transposase and inactivated derivatives, IS30 family
HB366_RS19315	COG0741	lytic transglycosylase activity
HB366_RS19350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB366_RS19430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII