locus-tag	class	description
HB367_RS00020	COG0582	viral genome integration into host DNA
HB367_RS00030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB367_RS00055	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS00075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB367_RS00075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB367_RS00135	COG0456	acetyltransferase
HB367_RS00145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB367_RS00150	COG0492	ferredoxin-NADP+ reductase activity
HB367_RS00155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB367_RS00155	COG1674	ftsk spoiiie
HB367_RS00160	COG1280	lysine exporter protein (LysE YggA)
HB367_RS00175	COG2894	cell division
HB367_RS00190	COG0204	Acyl-transferase
HB367_RS00195	COG2885	chlorophyll binding
HB367_RS00200	COG0210	DNA helicase
HB367_RS00210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_RS00225	COG0121	glutamine amidotransferase
HB367_RS00245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB367_RS00250	COG0735	belongs to the Fur family
HB367_RS00275	COG0420	3'-5' exonuclease activity
HB367_RS00295	COG1090	epimerase
HB367_RS00310	COG2050	protein possibly involved in aromatic compounds catabolism
HB367_RS00320	COG2814	Major facilitator Superfamily
HB367_RS00325	COG0405	Gamma-glutamyltransferase
HB367_RS00355	COG0477	Major facilitator Superfamily
HB367_RS00360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_RS00370	COG1595	DNA-templated transcription, initiation
HB367_RS00425	COG0531	amino acid
HB367_RS00430	COG2040	homocysteine
HB367_RS00455	COG1309	transcriptional regulator
HB367_RS00460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_RS00465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_RS00475	COG1607	acyl-coa hydrolase
HB367_RS00485	COG0523	cobalamin synthesis protein
HB367_RS00495	COG4681	YaeQ
HB367_RS00505	COG1649	PFAM Uncharacterised BCR, COG1649
HB367_RS00505	COG0726	polysaccharide deacetylase
HB367_RS00510	COG1215	transferase activity, transferring glycosyl groups
HB367_RS00520	COG1024	Enoyl-CoA hydratase
HB367_RS00535	COG1414	Transcriptional regulator
HB367_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS00570	COG2271	Major facilitator Superfamily
HB367_RS00580	COG2267	carboxylic ester hydrolase activity
HB367_RS00585	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS00600	COG0028	Belongs to the TPP enzyme family
HB367_RS00610	COG0477	Major facilitator Superfamily
HB367_RS00615	COG0242	peptide deformylase activity
HB367_RS00620	COG2066	Belongs to the glutaminase family
HB367_RS00625	COG2207	Transcriptional regulator
HB367_RS00630	COG2223	nitrite transmembrane transporter activity
HB367_RS00665	COG0306	phosphate transporter
HB367_RS00685	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB367_RS00730	COG4181	ATPase activity
HB367_RS00735	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB367_RS00765	COG0583	DNA-binding transcription factor activity
HB367_RS00775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_RS00780	COG1773	rubredoxin
HB367_RS00830	COG2851	Citrate transporter
HB367_RS00835	COG1253	flavin adenine dinucleotide binding
HB367_RS00875	COG0804	urea catabolic process
HB367_RS00885	COG0830	nickel cation binding
HB367_RS00900	COG0742	ribosomal rna small subunit methyltransferase
HB367_RS00905	COG0768	penicillin binding
HB367_RS00930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB367_RS00935	COG2878	Part of a membrane complex involved in electron transport
HB367_RS00940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB367_RS00950	COG3384	dioxygenase
HB367_RS00970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB367_RS01025	COG3620	sequence-specific DNA binding
HB367_RS01145	COG2194	sulfuric ester hydrolase activity
HB367_RS01175	COG0006	proline dipeptidase activity
HB367_RS01180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_RS01185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_RS01205	COG1279	arginine transmembrane transporter activity
HB367_RS01210	COG0583	DNA-binding transcription factor activity
HB367_RS01250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_RS01255	COG1388	LysM domain
HB367_RS01255	COG0741	lytic transglycosylase activity
HB367_RS01265	COG4174	ABC transporter (Permease)
HB367_RS01270	COG4239	(ABC) transporter, permease
HB367_RS01275	COG4172	Belongs to the ABC transporter superfamily
HB367_RS01295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_RS01305	COG5001	Diguanylate cyclase
HB367_RS01305	COG2203	Gaf domain
HB367_RS01305	COG4251	negative regulation of phosphorylation
HB367_RS01305	COG3706	GGDEF domain
HB367_RS01315	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_RS01315	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS01325	COG0582	viral genome integration into host DNA
HB367_RS01335	COG3328	transposase activity
HB367_RS01345	COG2161	toxin-antitoxin pair type II binding
HB367_RS01450	COG0514	ATP-dependent DNA helicase (RecQ)
HB367_RS01475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB367_RS01475	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB367_RS01500	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS01530	COG1113	amino acid transport
HB367_RS01560	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS01580	COG1113	amino acid transport
HB367_RS01605	COG0697	spore germination
HB367_RS01610	COG2721	sulfolactate sulfo-lyase activity
HB367_RS01615	COG2271	Major facilitator Superfamily
HB367_RS01620	COG4948	Mandelate Racemase Muconate Lactonizing
HB367_RS01630	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS01635	COG2186	Transcriptional regulator
HB367_RS01660	COG1960	acyl-CoA dehydrogenase activity
HB367_RS01670	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS01675	COG1024	Enoyl-CoA hydratase
HB367_RS01680	COG2814	Major facilitator Superfamily
HB367_RS01695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_RS01755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB367_RS01760	COG2072	flavoprotein involved in K transport
HB367_RS01765	COG0300	oxidoreductase activity
HB367_RS01775	COG1309	transcriptional regulator
HB367_RS01780	COG1741	Belongs to the pirin family
HB367_RS01795	COG2072	flavoprotein involved in K transport
HB367_RS01805	COG2252	PERMEase
HB367_RS01810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB367_RS01815	COG3038	cytochrome b561
HB367_RS01825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB367_RS01835	COG0527	aspartate kinase activity
HB367_RS01875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_RS01970	COG1484	DNA-dependent DNA replication
HB367_RS02015	COG3755	Protein conserved in bacteria
HB367_RS02200	COG0592	DNA-directed DNA polymerase activity
HB367_RS02265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_RS02290	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS02305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB367_RS02315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB367_RS02330	COG0667	Aldo Keto reductase
HB367_RS02340	COG1765	OsmC-like protein
HB367_RS02350	COG3328	transposase activity
HB367_RS02365	COG0542	response to heat
HB367_RS02400	COG2885	chlorophyll binding
HB367_RS02410	COG0625	glutathione transferase activity
HB367_RS02430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB367_RS02450	COG3634	alkyl hydroperoxide reductase activity
HB367_RS02460	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB367_RS02470	COG0450	alkyl hydroperoxide reductase
HB367_RS02475	COG1643	Atp-dependent helicase
HB367_RS02490	COG2814	Major facilitator Superfamily
HB367_RS02495	COG3135	benzoate transporter
HB367_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS02505	COG0543	2 iron, 2 sulfur cluster binding
HB367_RS02505	COG0633	Ferredoxin
HB367_RS02510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB367_RS02515	COG4638	Rieske (2fe-2S)
HB367_RS02520	COG0583	DNA-binding transcription factor activity
HB367_RS02570	COG1570	exodeoxyribonuclease VII activity
HB367_RS02610	COG1280	lysine exporter protein (LysE YggA)
HB367_RS02615	COG1278	Cold shock
HB367_RS02650	COG2814	Major facilitator Superfamily
HB367_RS02680	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS02705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB367_RS02715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB367_RS02720	COG1137	ATPase activity
HB367_RS02730	COG1538	Outer membrane efflux protein
HB367_RS02760	COG4122	O-methyltransferase activity
HB367_RS02770	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB367_RS02785	COG1522	sequence-specific DNA binding
HB367_RS02790	COG5006	permease, DMT superfamily
HB367_RS02800	COG1560	Kdo2-lipid A biosynthetic process
HB367_RS02810	COG2814	Major facilitator Superfamily
HB367_RS02830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_RS02855	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS02870	COG0583	DNA-binding transcription factor activity
HB367_RS02875	COG1914	H( )-stimulated, divalent metal cation uptake system
HB367_RS02895	COG4770	biotin carboxylase activity
HB367_RS02900	COG0038	chloride channel
HB367_RS02915	COG3328	transposase activity
HB367_RS02920	COG1309	transcriptional regulator
HB367_RS02930	COG1063	alcohol dehydrogenase
HB367_RS02945	COG0439	Biotin carboxylase
HB367_RS02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_RS02955	COG1733	regulation of RNA biosynthetic process
HB367_RS02970	COG0864	Transcriptional regulator
HB367_RS02980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_RS02985	COG1116	anion transmembrane transporter activity
HB367_RS03035	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS03110	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS03170	COG0590	tRNA wobble adenosine to inosine editing
HB367_RS03175	COG2807	transmembrane transport
HB367_RS03190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB367_RS03200	COG0789	Transcriptional regulator
HB367_RS03210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS03260	COG0531	amino acid
HB367_RS03265	COG1760	l-serine dehydratase
HB367_RS03270	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS03270	COG2030	dehydratase
HB367_RS03275	COG3396	Phenylacetate-CoA oxygenase
HB367_RS03280	COG3460	Phenylacetate-CoA oxygenase
HB367_RS03285	COG3396	Phenylacetate-CoA oxygenase
HB367_RS03290	COG2151	metal-sulfur cluster biosynthetic enzyme
HB367_RS03295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_RS03300	COG1024	Enoyl-CoA hydratase
HB367_RS03305	COG1024	Enoyl-CoA hydratase
HB367_RS03310	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_RS03315	COG0183	Belongs to the thiolase family
HB367_RS03320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB367_RS03325	COG3327	negative regulation of DNA-templated transcription, initiation
HB367_RS03335	COG2050	protein possibly involved in aromatic compounds catabolism
HB367_RS03350	COG3328	transposase activity
HB367_RS03355	COG0406	alpha-ribazole phosphatase activity
HB367_RS03390	COG0753	catalase activity
HB367_RS03395	COG3038	cytochrome b561
HB367_RS03400	COG0583	DNA-binding transcription factor activity
HB367_RS03410	COG1414	Transcriptional regulator
HB367_RS03415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_RS03430	COG1840	ABC-type Fe3 transport system, periplasmic component
HB367_RS03435	COG3842	ATPase activity
HB367_RS03450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB367_RS03455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB367_RS03460	COG2814	Major facilitator Superfamily
HB367_RS03465	COG1960	acyl-CoA dehydrogenase activity
HB367_RS03480	COG1024	Enoyl-CoA hydratase
HB367_RS03490	COG2814	Major facilitator Superfamily
HB367_RS03500	COG0183	Belongs to the thiolase family
HB367_RS03505	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB367_RS03510	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS03515	COG1024	Enoyl-CoA hydratase
HB367_RS03520	COG1960	acyl-CoA dehydrogenase activity
HB367_RS03525	COG2814	Major facilitator Superfamily
HB367_RS03530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_RS03535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_RS03545	COG2814	Major facilitator Superfamily
HB367_RS03555	COG1960	acyl-CoA dehydrogenase activity
HB367_RS03570	COG0583	DNA-binding transcription factor activity
HB367_RS03580	COG4770	biotin carboxylase activity
HB367_RS03585	COG1024	Enoyl-CoA hydratase
HB367_RS03590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB367_RS03595	COG1960	acyl-CoA dehydrogenase activity
HB367_RS03600	COG1309	transcriptional regulator
HB367_RS03605	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_RS03625	COG0583	DNA-binding transcription factor activity
HB367_RS03675	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS03695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB367_RS03715	COG2205	protein histidine kinase activity
HB367_RS03715	COG0784	Response regulator, receiver
HB367_RS03735	COG0765	amino acid transport
HB367_RS03740	COG0765	amino acid transport
HB367_RS03745	COG1126	abc transporter atp-binding protein
HB367_RS03750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_RS03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB367_RS03765	COG1280	lysine exporter protein (LysE YggA)
HB367_RS03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB367_RS03775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB367_RS03780	COG1045	serine acetyltransferase
HB367_RS03790	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS03795	COG0583	DNA-binding transcription factor activity
HB367_RS03800	COG0625	glutathione transferase activity
HB367_RS03805	COG0625	glutathione transferase activity
HB367_RS03810	COG0583	DNA-binding transcription factor activity
HB367_RS03820	COG1346	cytolysis
HB367_RS03825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS03840	COG2814	Major facilitator Superfamily
HB367_RS03850	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB367_RS03855	COG3052	prosthetic group binding
HB367_RS03875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB367_RS03895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS03905	COG1294	oxidase, subunit
HB367_RS03910	COG1271	oxidase subunit
HB367_RS03930	COG0477	Major facilitator Superfamily
HB367_RS03940	COG4521	taurine ABC transporter
HB367_RS03945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB367_RS03950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_RS03955	COG2175	clavaminate synthase activity
HB367_RS03965	COG1953	Uracil, thiamine, allantoin
HB367_RS03975	COG0583	DNA-binding transcription factor activity
HB367_RS04010	COG0640	Transcriptional regulator
HB367_RS04015	COG0798	PFAM Bile acid sodium symporter
HB367_RS04020	COG0583	DNA-binding transcription factor activity
HB367_RS04035	COG3634	alkyl hydroperoxide reductase activity
HB367_RS04070	COG1301	dicarboxylic acid transport
HB367_RS04075	COG0436	Aminotransferase
HB367_RS04085	COG0386	Belongs to the glutathione peroxidase family
HB367_RS04125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB367_RS04150	COG0012	GTP binding
HB367_RS04155	COG2011	ABC-type metal ion transport system permease component
HB367_RS04160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB367_RS04170	COG1464	Belongs to the NlpA lipoprotein family
HB367_RS04200	COG0765	amino acid transport
HB367_RS04205	COG0765	amino acid transport
HB367_RS04210	COG1126	abc transporter atp-binding protein
HB367_RS04220	COG1522	sequence-specific DNA binding
HB367_RS04235	COG1309	transcriptional regulator
HB367_RS04255	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS04260	COG0583	DNA-binding transcription factor activity
HB367_RS04270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB367_RS04295	COG3121	Chaperone
HB367_RS04300	COG3539	Fimbrial protein
HB367_RS04325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB367_RS04325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB367_RS04370	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB367_RS04380	COG2353	YceI-like domain
HB367_RS04390	COG3698	Phosphodiester glycosidase
HB367_RS04405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB367_RS04410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB367_RS04410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB367_RS04410	COG0506	proline dehydrogenase activity
HB367_RS04420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB367_RS04425	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB367_RS04440	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS04455	COG1132	(ABC) transporter
HB367_RS04460	COG3328	transposase activity
HB367_RS04465	COG3122	Protein conserved in bacteria
HB367_RS04470	COG3619	membrane
HB367_RS04480	COG0640	Transcriptional regulator
HB367_RS04490	COG2850	peptidyl-arginine hydroxylation
HB367_RS04495	COG0424	maF-like protein
HB367_RS04515	COG0191	fructose-bisphosphate aldolase activity
HB367_RS04520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB367_RS04535	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB367_RS04545	COG1192	Involved in chromosome partitioning
HB367_RS04550	COG1475	DNA binding
HB367_RS04555	COG0811	peptide transport
HB367_RS04565	COG1132	(ABC) transporter
HB367_RS04570	COG1663	tetraacyldisaccharide 4'-kinase activity
HB367_RS04590	COG0084	hydrolase, TatD family'
HB367_RS04655	COG0776	regulation of translation
HB367_RS04685	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB367_RS04690	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB367_RS04735	COG4166	transmembrane transport
HB367_RS04740	COG0339	signal peptide processing
HB367_RS04745	COG0601	transmembrane transport
HB367_RS04785	COG0702	epimerase
HB367_RS04790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB367_RS04810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB367_RS04840	COG0316	Belongs to the HesB IscA family
HB367_RS04845	COG0822	iron-sulfur transferase activity
HB367_RS04870	COG0776	regulation of translation
HB367_RS04875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB367_RS04880	COG2207	Transcriptional regulator
HB367_RS04885	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB367_RS04890	COG1960	acyl-CoA dehydrogenase activity
HB367_RS04895	COG1960	acyl-CoA dehydrogenase activity
HB367_RS04910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB367_RS04925	COG2814	Major facilitator Superfamily
HB367_RS04930	COG4264	IucA IucC family
HB367_RS04935	COG4264	IucA IucC family
HB367_RS04945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB367_RS04990	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB367_RS04995	COG0406	alpha-ribazole phosphatase activity
HB367_RS05010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB367_RS05015	COG0730	response to heat
HB367_RS05035	COG4773	Receptor
HB367_RS05040	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_RS05055	COG1131	(ABC) transporter
HB367_RS05060	COG0842	Transport permease protein
HB367_RS05065	COG0842	Transport permease protein
HB367_RS05090	COG0537	adenosine 5'-monophosphoramidase activity
HB367_RS05100	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS05125	COG2226	methyltransferase
HB367_RS05150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB367_RS05185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB367_RS05195	COG0133	tryptophan synthase activity
HB367_RS05210	COG3706	GGDEF domain
HB367_RS05225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB367_RS05230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB367_RS05235	COG0022	dehydrogenase e1 component
HB367_RS05240	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB367_RS05245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_RS05255	COG1063	alcohol dehydrogenase
HB367_RS05260	COG3781	membrane
HB367_RS05270	COG3453	Protein conserved in bacteria
HB367_RS05270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_RS05280	COG0730	response to heat
HB367_RS05295	COG2207	Transcriptional regulator
HB367_RS05295	COG3708	Transcriptional regulator
HB367_RS05300	COG1733	regulation of RNA biosynthetic process
HB367_RS05305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB367_RS05315	COG2188	Transcriptional regulator
HB367_RS05330	COG4521	taurine ABC transporter
HB367_RS05335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_RS05355	COG0477	Major facilitator Superfamily
HB367_RS05365	COG1027	Aspartate ammonia-lyase
HB367_RS05380	COG0583	DNA-binding transcription factor activity
HB367_RS05385	COG0583	DNA-binding transcription factor activity
HB367_RS05390	COG0183	Belongs to the thiolase family
HB367_RS05395	COG2031	fatty acid transporter
HB367_RS05410	COG0583	DNA-binding transcription factor activity
HB367_RS05420	COG2610	gluconate transmembrane transporter activity
HB367_RS05425	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS05430	COG2207	Transcriptional regulator
HB367_RS05450	COG3328	transposase activity
HB367_RS05465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_RS05480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_RS05480	COG0543	2 iron, 2 sulfur cluster binding
HB367_RS05485	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB367_RS05490	COG4638	Rieske (2fe-2S)
HB367_RS05500	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB367_RS05505	COG4149	molybdate abc transporter
HB367_RS05510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB367_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS05520	COG1535	isochorismatase
HB367_RS05520	COG3433	isochorismatase activity
HB367_RS05585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB367_RS05600	COG0753	catalase activity
HB367_RS05610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB367_RS05635	COG3539	Fimbrial protein
HB367_RS05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB367_RS05670	COG2072	flavoprotein involved in K transport
HB367_RS05680	COG1538	Outer membrane efflux protein
HB367_RS05685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB367_RS05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS05695	COG0745	RESPONSE REGULATOR receiver
HB367_RS05700	COG2205	protein histidine kinase activity
HB367_RS05710	COG2207	Transcriptional regulator
HB367_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS05735	COG1073	alpha beta
HB367_RS05770	COG0556	nucleotide-excision repair
HB367_RS05785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB367_RS05840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB367_RS05860	COG1120	ATPase activity
HB367_RS05880	COG2084	Dehydrogenase
HB367_RS05890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB367_RS05895	COG0583	DNA-binding transcription factor activity
HB367_RS05905	COG0129	dihydroxy-acid dehydratase activity
HB367_RS05910	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS05925	COG1566	PFAM secretion protein HlyD family protein
HB367_RS05950	COG0583	DNA-binding transcription factor activity
HB367_RS05965	COG2188	Transcriptional regulator
HB367_RS06010	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_RS06020	COG1960	acyl-CoA dehydrogenase activity
HB367_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS06045	COG0583	DNA-binding transcription factor activity
HB367_RS06050	COG1309	transcriptional regulator
HB367_RS06090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_RS06090	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS06105	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS06125	COG2186	Transcriptional regulator
HB367_RS06135	COG0583	DNA-binding transcription factor activity
HB367_RS06140	COG4948	Mandelate Racemase Muconate Lactonizing
HB367_RS06145	COG4829	muconolactone delta-isomerase
HB367_RS06155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_RS06160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_RS06165	COG0183	Belongs to the thiolase family
HB367_RS06170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_RS06180	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS06190	COG3733	amine oxidase
HB367_RS06200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS06220	COG4638	Rieske (2fe-2S)
HB367_RS06240	COG0154	amidase activity
HB367_RS06250	COG2814	Major facilitator Superfamily
HB367_RS06275	COG1960	acyl-CoA dehydrogenase activity
HB367_RS06280	COG0583	DNA-binding transcription factor activity
HB367_RS06285	COG1414	Transcriptional regulator
HB367_RS06300	COG2391	methyltransferase activity
HB367_RS06310	COG4993	Dehydrogenase
HB367_RS06315	COG3659	wide pore channel activity
HB367_RS06320	COG3420	alginic acid biosynthetic process
HB367_RS06325	COG0710	3-dehydroquinate dehydratase activity
HB367_RS06330	COG3485	protocatechuate 3,4-dioxygenase
HB367_RS06335	COG3485	protocatechuate 3,4-dioxygenase
HB367_RS06340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB367_RS06345	COG2271	Major facilitator Superfamily
HB367_RS06350	COG0596	Alpha beta hydrolase
HB367_RS06355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB367_RS06360	COG0183	Belongs to the thiolase family
HB367_RS06365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB367_RS06370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB367_RS06380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB367_RS06385	COG2323	membrane
HB367_RS06430	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB367_RS06430	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS06455	COG0542	response to heat
HB367_RS06460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB367_RS06495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB367_RS06500	COG0569	domain protein
HB367_RS06505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB367_RS06520	COG4774	siderophore transport
HB367_RS06525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB367_RS06535	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB367_RS06540	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS06555	COG1294	oxidase, subunit
HB367_RS06560	COG4890	Cyd operon protein YbgT
HB367_RS06575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB367_RS06585	COG0552	protein localization to endoplasmic reticulum
HB367_RS06610	COG0517	IMP dehydrogenase activity
HB367_RS06610	COG0516	GMP reductase activity
HB367_RS06615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB367_RS06620	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB367_RS06630	COG0583	DNA-binding transcription factor activity
HB367_RS06635	COG0024	Methionine aminopeptidase
HB367_RS06665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB367_RS06665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB367_RS06670	COG1105	Belongs to the carbohydrate kinase PfkB family
HB367_RS06675	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB367_RS06675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB367_RS06675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB367_RS06690	COG5001	Diguanylate cyclase
HB367_RS06690	COG3300	MHYT domain
HB367_RS06705	COG2135	peptidase activity
HB367_RS06710	COG0659	secondary active sulfate transmembrane transporter activity
HB367_RS06725	COG1113	amino acid transport
HB367_RS06735	COG1522	sequence-specific DNA binding
HB367_RS06760	COG1011	Hydrolase
HB367_RS06765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB367_RS06775	COG2137	regulation of response to DNA damage stimulus
HB367_RS06790	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_RS06810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB367_RS06825	COG0575	Belongs to the CDS family
HB367_RS06830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB367_RS06855	COG3852	Histidine kinase
HB367_RS06860	COG2204	response regulator
HB367_RS06915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB367_RS06920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB367_RS06940	COG0697	spore germination
HB367_RS06945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS06955	COG0303	'Molybdopterin
HB367_RS06960	COG0315	cyclic pyranopterin monophosphate synthase activity
HB367_RS06960	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB367_RS06975	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB367_RS06990	COG0243	molybdopterin cofactor binding
HB367_RS06995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_RS07000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_RS07000	COG2146	nitrite reductase [NAD(P)H] activity
HB367_RS07010	COG0745	RESPONSE REGULATOR receiver
HB367_RS07015	COG1116	anion transmembrane transporter activity
HB367_RS07015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_RS07035	COG0511	ligase activity, forming carbon-carbon bonds
HB367_RS07050	COG2814	Major facilitator Superfamily
HB367_RS07080	COG3293	Transposase
HB367_RS07085	COG1063	alcohol dehydrogenase
HB367_RS07095	COG3179	chitinase
HB367_RS07145	COG1598	PFAM Uncharacterised protein family UPF0150
HB367_RS07245	COG5410	chromosome segregation
HB367_RS07400	COG0069	glutamate synthase activity
HB367_RS07430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB367_RS07440	COG1454	alcohol dehydrogenase
HB367_RS07445	COG0824	Thioesterase
HB367_RS07455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB367_RS07485	COG2030	dehydratase
HB367_RS07495	COG0183	Belongs to the thiolase family
HB367_RS07505	COG0583	DNA-binding transcription factor activity
HB367_RS07510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB367_RS07520	COG1522	sequence-specific DNA binding
HB367_RS07525	COG3135	benzoate transporter
HB367_RS07535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB367_RS07560	COG0589	response to stress
HB367_RS07565	COG0488	(ABC) transporter
HB367_RS07585	COG4773	Receptor
HB367_RS07595	COG3328	transposase activity
HB367_RS07625	COG0668	transmembrane transport
HB367_RS07635	COG1309	transcriptional regulator
HB367_RS07650	COG1605	Chorismate mutase
HB367_RS07690	COG0308	aminopeptidase N
HB367_RS07715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB367_RS07720	COG1454	alcohol dehydrogenase
HB367_RS07740	COG0531	amino acid
HB367_RS07745	COG4303	Ethanolamine ammonia lyase large subunit
HB367_RS07750	COG4302	ethanolamine ammonia-lyase activity
HB367_RS07755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB367_RS07755	COG0519	Catalyzes the synthesis of GMP from XMP
HB367_RS07760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB367_RS07770	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB367_RS07785	COG0697	spore germination
HB367_RS07790	COG1923	regulation of RNA biosynthetic process
HB367_RS07800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB367_RS07805	COG0802	atpase or kinase
HB367_RS07825	COG1187	pseudouridine synthase activity
HB367_RS07840	COG0583	DNA-binding transcription factor activity
HB367_RS07855	COG2814	Major facilitator Superfamily
HB367_RS07860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB367_RS07985	COG0729	surface antigen
HB367_RS08005	COG0174	glutamine synthetase
HB367_RS08010	COG0745	RESPONSE REGULATOR receiver
HB367_RS08015	COG2205	protein histidine kinase activity
HB367_RS08020	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB367_RS08025	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB367_RS08030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB367_RS08055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_RS08060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_RS08065	COG1960	acyl-CoA dehydrogenase activity
HB367_RS08095	COG0583	DNA-binding transcription factor activity
HB367_RS08110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB367_RS08120	COG3658	cytochrome
HB367_RS08125	COG1215	transferase activity, transferring glycosyl groups
HB367_RS08130	COG0726	polysaccharide deacetylase
HB367_RS08130	COG1649	PFAM Uncharacterised BCR, COG1649
HB367_RS08155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB367_RS08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB367_RS08170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB367_RS08195	COG0305	Participates in initiation and elongation during chromosome replication
HB367_RS08200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB367_RS08210	COG1305	Transglutaminase-like
HB367_RS08220	COG2308	Evidence 4 Homologs of previously reported genes of
HB367_RS08250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB367_RS08255	COG0138	bifunctional purine biosynthesis protein purh
HB367_RS08260	COG0151	Belongs to the GarS family
HB367_RS08265	COG1464	Belongs to the NlpA lipoprotein family
HB367_RS08270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB367_RS08275	COG2011	ABC-type metal ion transport system permease component
HB367_RS08280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_RS08290	COG1301	dicarboxylic acid transport
HB367_RS08320	COG1794	racemase activity, acting on amino acids and derivatives
HB367_RS08340	COG0745	RESPONSE REGULATOR receiver
HB367_RS08345	COG0642	Histidine kinase
HB367_RS08350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB367_RS08360	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB367_RS08400	COG2351	hydroxyisourate hydrolase activity
HB367_RS08410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB367_RS08410	COG3008	intermembrane lipid transfer
HB367_RS08415	COG2995	paraquat-inducible protein a
HB367_RS08445	COG1051	belongs to the nudix hydrolase family
HB367_RS08450	COG2186	Transcriptional regulator
HB367_RS08460	COG0786	glutamate:sodium symporter activity
HB367_RS08465	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB367_RS08490	COG3111	PFAM Bacterial OB fold (BOF) protein
HB367_RS08590	COG1610	YqeY-like protein
HB367_RS08595	COG4783	chaperone-mediated protein folding
HB367_RS08620	COG1286	toxin biosynthetic process
HB367_RS08755	COG0778	Nitroreductase
HB367_RS08765	COG0513	Belongs to the DEAD box helicase family
HB367_RS08785	COG2363	Small membrane protein
HB367_RS08815	COG4650	regulator
HB367_RS08820	COG1234	tRNA 3'-trailer cleavage
HB367_RS08825	COG1690	Belongs to the RtcB family
HB367_RS08845	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB367_RS08855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB367_RS08870	COG1960	acyl-CoA dehydrogenase activity
HB367_RS08875	COG1301	dicarboxylic acid transport
HB367_RS08880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB367_RS08885	COG3139	Protein of unknown function (DUF1315)
HB367_RS08890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB367_RS08895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB367_RS08905	COG0494	nUDIX hydrolase
HB367_RS08915	COG0642	Histidine kinase
HB367_RS08920	COG0745	RESPONSE REGULATOR receiver
HB367_RS08940	COG1720	tRNA m6t6A37 methyltransferase activity
HB367_RS08950	COG0384	phenazine biosynthesis protein PhzF
HB367_RS08955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS08965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB367_RS08975	COG4598	ABC transporter
HB367_RS08980	COG4160	amino acid transport
HB367_RS08985	COG4215	(ABC) transporter
HB367_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS09050	COG3179	chitinase
HB367_RS09100	COG1598	PFAM Uncharacterised protein family UPF0150
HB367_RS09195	COG5410	chromosome segregation
HB367_RS09215	COG2357	RelA SpoT domain protein
HB367_RS09295	COG0305	Participates in initiation and elongation during chromosome replication
HB367_RS09355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_RS09420	COG0564	pseudouridine synthase activity
HB367_RS09430	COG0358	DNA primase activity
HB367_RS09445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB367_RS09475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB367_RS09505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB367_RS09515	COG0351	phosphomethylpyrimidine kinase
HB367_RS09515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB367_RS09515	COG0352	thiamine-phosphate diphosphorylase activity
HB367_RS09520	COG1652	LysM domain
HB367_RS09545	COG1399	metal-binding, possibly nucleic acid-binding protein
HB367_RS09550	COG3101	peptidyl-lysine hydroxylation
HB367_RS09555	COG0009	L-threonylcarbamoyladenylate synthase
HB367_RS09560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB367_RS09565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB367_RS09580	COG4106	trans-aconitate 2-methyltransferase activity
HB367_RS09595	COG0596	Alpha beta hydrolase
HB367_RS09595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_RS09595	COG2226	methyltransferase
HB367_RS09600	COG1877	trehalose-phosphatase activity
HB367_RS09605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB367_RS09610	COG2223	nitrite transmembrane transporter activity
HB367_RS09630	COG1196	nuclear chromosome segregation
HB367_RS09640	COG0730	response to heat
HB367_RS09655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB367_RS09665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB367_RS09715	COG0489	protein tyrosine kinase activity
HB367_RS09725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_RS09725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_RS09755	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB367_RS09760	COG2081	HI0933 family
HB367_RS09770	COG0668	transmembrane transport
HB367_RS09790	COG0583	DNA-binding transcription factor activity
HB367_RS09810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB367_RS09815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB367_RS09845	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB367_RS09880	COG2205	protein histidine kinase activity
HB367_RS09885	COG0745	RESPONSE REGULATOR receiver
HB367_RS09905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB367_RS09920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_RS09935	COG0583	DNA-binding transcription factor activity
HB367_RS09965	COG0583	DNA-binding transcription factor activity
HB367_RS09980	COG0583	DNA-binding transcription factor activity
HB367_RS09985	COG1053	succinate dehydrogenase
HB367_RS09995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB367_RS10000	COG2814	Major facilitator Superfamily
HB367_RS10005	COG1960	acyl-CoA dehydrogenase activity
HB367_RS10010	COG0583	DNA-binding transcription factor activity
HB367_RS10015	COG1063	alcohol dehydrogenase
HB367_RS10045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB367_RS10050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB367_RS10055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB367_RS10070	COG3667	copper resistance
HB367_RS10075	COG2132	Multicopper oxidase
HB367_RS10085	COG0561	phosphatase activity
HB367_RS10090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB367_RS10100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB367_RS10115	COG1214	PFAM Peptidase M22, glycoprotease
HB367_RS10140	COG3328	transposase activity
HB367_RS10150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB367_RS10160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB367_RS10165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB367_RS10170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB367_RS10230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB367_RS10240	COG1846	Transcriptional regulator
HB367_RS10245	COG1764	response to oxidative stress
HB367_RS10285	COG0037	tRNA processing
HB367_RS10295	COG0248	Ppx GppA phosphatase
HB367_RS10325	COG0072	phenylalanine-tRNA ligase activity
HB367_RS10365	COG1238	metal cluster binding
HB367_RS10370	COG0625	glutathione transferase activity
HB367_RS10385	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_RS10390	COG3028	Belongs to the UPF0307 family
HB367_RS10395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB367_RS10415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB367_RS10420	COG0617	tRNA 3'-terminal CCA addition
HB367_RS10425	COG1555	photosystem II stabilization
HB367_RS10430	COG3956	TIGRFAM MazG family protein
HB367_RS10440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB367_RS10460	COG2205	protein histidine kinase activity
HB367_RS10460	COG0784	Response regulator, receiver
HB367_RS10460	COG5002	protein histidine kinase activity
HB367_RS10465	COG1024	Enoyl-CoA hydratase
HB367_RS10470	COG2084	Dehydrogenase
HB367_RS10475	COG3622	Belongs to the hyi family
HB367_RS10505	COG0697	spore germination
HB367_RS10515	COG2814	Major facilitator Superfamily
HB367_RS10520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB367_RS10530	COG0583	DNA-binding transcription factor activity
HB367_RS10540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB367_RS10550	COG0084	hydrolase, TatD family'
HB367_RS10565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB367_RS10590	COG2130	NADP-dependent
HB367_RS10595	COG1309	transcriptional regulator
HB367_RS10605	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS10615	COG1979	alcohol dehydrogenase
HB367_RS10630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB367_RS10645	COG0604	alcohol dehydrogenase
HB367_RS10645	COG3321	synthase
HB367_RS10650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB367_RS10655	COG0583	DNA-binding transcription factor activity
HB367_RS10660	COG4221	oxidoreductase activity
HB367_RS10700	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS10725	COG0440	acetolactate synthase activity
HB367_RS10730	COG0028	Belongs to the TPP enzyme family
HB367_RS10755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS10760	COG1136	(ABC) transporter
HB367_RS10760	COG0577	efflux transmembrane transporter activity
HB367_RS10765	COG1538	Outer membrane efflux protein
HB367_RS10780	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB367_RS10785	COG1162	GTPase activity
HB367_RS10795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB367_RS10835	COG1426	Protein conserved in bacteria
HB367_RS10870	COG0793	Belongs to the peptidase S41A family
HB367_RS10885	COG2267	carboxylic ester hydrolase activity
HB367_RS10895	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS10900	COG3265	gluconokinase activity
HB367_RS10910	COG0800	Aldolase
HB367_RS10920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB367_RS10925	COG0280	phosphate acetyltransferase
HB367_RS10925	COG0857	belongs to the CobB CobQ family
HB367_RS10930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB367_RS10930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB367_RS10950	COG0740	serine-type endopeptidase activity
HB367_RS10960	COG4774	siderophore transport
HB367_RS10970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB367_RS10980	COG2813	Specifically methylates the guanine in position
HB367_RS10980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB367_RS11085	COG0788	formyltetrahydrofolate deformylase activity
HB367_RS11110	COG4651	solute:proton antiporter activity
HB367_RS11110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB367_RS11135	COG0724	RNA recognition motif
HB367_RS11140	COG0210	DNA helicase
HB367_RS11165	COG1733	regulation of RNA biosynthetic process
HB367_RS11175	COG2900	Belongs to the SlyX family
HB367_RS11185	COG1280	lysine exporter protein (LysE YggA)
HB367_RS11190	COG1560	Kdo2-lipid A biosynthetic process
HB367_RS11200	COG1301	dicarboxylic acid transport
HB367_RS11255	COG0473	3-isopropylmalate dehydrogenase activity
HB367_RS11320	COG0583	DNA-binding transcription factor activity
HB367_RS11330	COG0625	glutathione transferase activity
HB367_RS11335	COG2378	regulation of single-species biofilm formation
HB367_RS11340	COG0546	phosphoglycolate phosphatase activity
HB367_RS11355	COG1530	ribonuclease E activity
HB367_RS11360	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_RS11375	COG0583	DNA-binding transcription factor activity
HB367_RS11380	COG4221	oxidoreductase activity
HB367_RS11385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB367_RS11410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB367_RS11450	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB367_RS11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB367_RS11470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB367_RS11480	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB367_RS11480	COG0644	oxidoreductase
HB367_RS11490	COG0425	Belongs to the sulfur carrier protein TusA family
HB367_RS11495	COG4535	Mg2 and Co2 transporter CorC
HB367_RS11505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB367_RS11525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB367_RS11530	COG0475	glutathione-regulated potassium exporter activity
HB367_RS11530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB367_RS11545	COG0484	heat shock protein binding
HB367_RS11550	COG0789	Transcriptional regulator
HB367_RS11555	COG0598	Magnesium transport protein CorA
HB367_RS11575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB367_RS11580	COG1074	ATP-dependent DNA helicase activity
HB367_RS11585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB367_RS11605	COG2226	methyltransferase
HB367_RS11620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_RS11625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB367_RS11640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB367_RS11640	COG2111	Na H antiporter
HB367_RS11645	COG1006	Multisubunit Na H antiporter MnhC subunit
HB367_RS11650	COG0651	ATP synthesis coupled electron transport
HB367_RS11660	COG2212	antiporter activity
HB367_RS11680	COG0195	Participates in both transcription termination and antitermination
HB367_RS11730	COG0237	dephospho-CoA kinase activity
HB367_RS11740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB367_RS11755	COG0497	DNA recombination
HB367_RS11765	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB367_RS11795	COG2169	Transcriptional regulator
HB367_RS11795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB367_RS11800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB367_RS11860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB367_RS11875	COG0326	Molecular chaperone. Has ATPase activity
HB367_RS11890	COG2056	Na+-H+ antiporter family
HB367_RS11895	COG0596	Alpha beta hydrolase
HB367_RS11910	COG3328	transposase activity
HB367_RS11995	COG0546	phosphoglycolate phosphatase activity
HB367_RS12000	COG1716	ATPase activity
HB367_RS12045	COG0181	hydroxymethylbilane synthase activity
HB367_RS12055	COG3275	phosphorelay sensor kinase activity
HB367_RS12075	COG1538	Outer membrane efflux protein
HB367_RS12080	COG0697	spore germination
HB367_RS12105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB367_RS12110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB367_RS12115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB367_RS12120	COG0772	Belongs to the SEDS family
HB367_RS12145	COG4974	Belongs to the 'phage' integrase family
HB367_RS12150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_RS12160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB367_RS12170	COG2197	response regulator
HB367_RS12185	COG0793	Belongs to the peptidase S41A family
HB367_RS12190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB367_RS12195	COG0795	lipopolysaccharide-transporting ATPase activity
HB367_RS12235	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB367_RS12235	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB367_RS12245	COG0004	ammonium transporteR
HB367_RS12250	COG0347	Belongs to the P(II) protein family
HB367_RS12260	COG0606	chelatase, subunit chli
HB367_RS12285	COG1061	Type III restriction enzyme res subunit
HB367_RS12300	COG0659	secondary active sulfate transmembrane transporter activity
HB367_RS12305	COG0589	response to stress
HB367_RS12345	COG0606	chelatase, subunit chli
HB367_RS12350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS12355	COG0235	Class ii aldolase
HB367_RS12360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_RS12390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB367_RS12405	COG0318	PFAM AMP-dependent synthetase and ligase
HB367_RS12415	COG0477	Major facilitator Superfamily
HB367_RS12420	COG2860	membrane
HB367_RS12425	COG3012	SEC-C Motif Domain Protein
HB367_RS12430	COG1253	flavin adenine dinucleotide binding
HB367_RS12440	COG2814	Major facilitator Superfamily
HB367_RS12450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_RS12485	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB367_RS12495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB367_RS12530	COG1309	transcriptional regulator
HB367_RS12565	COG0758	DNA mediated transformation
HB367_RS12575	COG0697	spore germination
HB367_RS12580	COG1309	transcriptional regulator
HB367_RS12595	COG0386	Belongs to the glutathione peroxidase family
HB367_RS12665	COG1121	(ABC) transporter
HB367_RS12670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB367_RS12675	COG1280	lysine exporter protein (LysE YggA)
HB367_RS12680	COG2837	iron assimilation
HB367_RS12690	COG0281	malic enzyme
HB367_RS12735	COG0519	Catalyzes the synthesis of GMP from XMP
HB367_RS12735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB367_RS12740	COG4399	Belongs to the UPF0754 family
HB367_RS12745	COG2259	Doxx family
HB367_RS12750	COG0586	Pfam SNARE associated Golgi protein
HB367_RS12765	COG1192	Involved in chromosome partitioning
HB367_RS12775	COG0271	Belongs to the BolA IbaG family
HB367_RS12795	COG1024	Enoyl-CoA hydratase
HB367_RS12800	COG1024	Enoyl-CoA hydratase
HB367_RS12805	COG1960	acyl-CoA dehydrogenase activity
HB367_RS12810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_RS12830	COG1113	amino acid transport
HB367_RS12835	COG1113	amino acid transport
HB367_RS12840	COG0251	oxidation-reduction process
HB367_RS12880	COG0564	pseudouridine synthase activity
HB367_RS12915	COG1051	belongs to the nudix hydrolase family
HB367_RS12935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB367_RS12950	COG1802	Transcriptional regulator
HB367_RS12960	COG1448	Aminotransferase
HB367_RS12965	COG0277	FAD linked oxidase domain protein
HB367_RS12975	COG2186	Transcriptional regulator
HB367_RS12985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_RS12990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB367_RS13005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB367_RS13010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB367_RS13015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB367_RS13070	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB367_RS13075	COG1596	polysaccharide export
HB367_RS13100	COG0728	peptidoglycan biosynthetic process
HB367_RS13105	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB367_RS13165	COG0546	phosphoglycolate phosphatase activity
HB367_RS13170	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS13190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_RS13195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB367_RS13200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB367_RS13205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB367_RS13210	COG1116	anion transmembrane transporter activity
HB367_RS13215	COG1309	transcriptional regulator
HB367_RS13220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB367_RS13230	COG0196	riboflavin kinase activity
HB367_RS13235	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB367_RS13245	COG1047	Peptidyl-prolyl cis-trans
HB367_RS13285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB367_RS13340	COG2951	lytic endotransglycosylase activity
HB367_RS13345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB367_RS13360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB367_RS13370	COG3328	transposase activity
HB367_RS13380	COG0671	phosphoesterase, PA-phosphatase related
HB367_RS13385	COG0861	Integral membrane protein TerC family
HB367_RS13395	COG0754	glutathionylspermidine amidase activity
HB367_RS13405	COG0402	S-adenosylhomocysteine deaminase activity
HB367_RS13420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_RS13425	COG1230	cation diffusion facilitator family transporter
HB367_RS13440	COG0706	membrane insertase activity
HB367_RS13465	COG0592	DNA-directed DNA polymerase activity
HB367_RS13475	COG0187	DNA topoisomerase II activity
HB367_RS13485	COG0586	Pfam SNARE associated Golgi protein
HB367_RS13490	COG0488	(ABC) transporter
HB367_RS13515	COG0596	Alpha beta hydrolase
HB367_RS13520	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB367_RS13525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB367_RS13565	COG0733	neurotransmitter:sodium symporter activity
HB367_RS13600	COG0583	DNA-binding transcription factor activity
HB367_RS13605	COG2233	PERMEase
HB367_RS13620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS13655	COG2814	Major facilitator Superfamily
HB367_RS13660	COG0656	L-ascorbic acid biosynthetic process
HB367_RS13665	COG0583	DNA-binding transcription factor activity
HB367_RS13680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB367_RS13685	COG1064	alcohol dehydrogenase
HB367_RS13690	COG2818	Glycosylase
HB367_RS13705	COG1194	a g-specific adenine glycosylase
HB367_RS13725	COG2983	Belongs to the UPF0260 family
HB367_RS13730	COG2133	pyrroloquinoline quinone binding
HB367_RS13735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB367_RS13740	COG2116	formate transmembrane transporter activity
HB367_RS13760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB367_RS13765	COG1335	isochorismatase
HB367_RS13770	COG0385	Bile acid
HB367_RS13775	COG0534	Mate efflux family protein
HB367_RS13780	COG1683	Conserved Protein
HB367_RS13800	COG0625	glutathione transferase activity
HB367_RS13810	COG1113	amino acid transport
HB367_RS13820	COG0523	cobalamin synthesis protein
HB367_RS13830	COG2188	Transcriptional regulator
HB367_RS13860	COG0010	Belongs to the arginase family
HB367_RS13875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB367_RS13880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB367_RS13890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB367_RS13895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB367_RS13985	COG0436	Aminotransferase
HB367_RS13990	COG2733	membrane
HB367_RS14005	COG2918	glutathione biosynthetic process
HB367_RS14075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_RS14090	COG3501	Rhs element vgr protein
HB367_RS14150	COG3150	esterase
HB367_RS14160	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS14165	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB367_RS14175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB367_RS14190	COG2233	PERMEase
HB367_RS14195	COG2351	hydroxyisourate hydrolase activity
HB367_RS14230	COG3706	GGDEF domain
HB367_RS14245	COG1393	Belongs to the ArsC family
HB367_RS14250	COG0708	Exodeoxyribonuclease III
HB367_RS14275	COG0189	ligase activity
HB367_RS14295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB367_RS14305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB367_RS14320	COG4942	peptidase
HB367_RS14330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB367_RS14340	COG2119	membrane
HB367_RS14345	COG4774	siderophore transport
HB367_RS14350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB367_RS14350	COG0426	domain, Protein
HB367_RS14375	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB367_RS14395	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS14400	COG1519	Transferase
HB367_RS14405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB367_RS14410	COG0668	transmembrane transport
HB367_RS14420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB367_RS14425	COG1335	isochorismatase
HB367_RS14430	COG1522	sequence-specific DNA binding
HB367_RS14455	COG2198	Histidine kinase
HB367_RS14455	COG2205	protein histidine kinase activity
HB367_RS14455	COG0784	Response regulator, receiver
HB367_RS14460	COG3162	membrane
HB367_RS14465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB367_RS14475	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB367_RS14485	COG3706	GGDEF domain
HB367_RS14490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB367_RS14495	COG1309	transcriptional regulator
HB367_RS14515	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB367_RS14515	COG0351	phosphomethylpyrimidine kinase
HB367_RS14515	COG0352	thiamine-phosphate diphosphorylase activity
HB367_RS14525	COG2814	Major facilitator Superfamily
HB367_RS14540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB367_RS14550	COG1113	amino acid transport
HB367_RS14560	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB367_RS14565	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS14575	COG1335	isochorismatase
HB367_RS14605	COG2814	Major facilitator Superfamily
HB367_RS14610	COG0583	DNA-binding transcription factor activity
HB367_RS14665	COG0667	Aldo Keto reductase
HB367_RS14685	COG1129	ABC transporter
HB367_RS14695	COG2207	Transcriptional regulator
HB367_RS14750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB367_RS14765	COG2329	Antibiotic biosynthesis monooxygenase
HB367_RS14780	COG1132	(ABC) transporter
HB367_RS14800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB367_RS14830	COG0427	acetyl-CoA hydrolase
HB367_RS14845	COG0745	RESPONSE REGULATOR receiver
HB367_RS14855	COG0659	secondary active sulfate transmembrane transporter activity
HB367_RS14860	COG4221	oxidoreductase activity
HB367_RS14870	COG0488	(ABC) transporter
HB367_RS14935	COG0833	amino acid
HB367_RS14980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB367_RS14985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB367_RS15000	COG2226	methyltransferase
HB367_RS15050	COG0067	glutamate synthase
HB367_RS15050	COG0069	glutamate synthase activity
HB367_RS15050	COG0070	glutamate synthase
HB367_RS15055	COG0493	'glutamate synthase
HB367_RS15065	COG1704	LemA family
HB367_RS15070	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB367_RS15090	COG3307	-O-antigen
HB367_RS15110	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB367_RS15125	COG0194	GDP metabolic process
HB367_RS15175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB367_RS15195	COG5380	lipid catabolic process
HB367_RS15200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB367_RS15225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB367_RS15230	COG0277	FAD linked oxidase domain protein
HB367_RS15240	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB367_RS15245	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_RS15260	COG1289	transmembrane transporter activity
HB367_RS15270	COG0628	permease
HB367_RS15275	COG1192	Involved in chromosome partitioning
HB367_RS15305	COG0833	amino acid
HB367_RS15310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB367_RS15315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB367_RS15325	COG1012	belongs to the aldehyde dehydrogenase family
HB367_RS15365	COG0583	DNA-binding transcription factor activity
HB367_RS15425	COG0517	IMP dehydrogenase activity
HB367_RS15430	COG1983	PspC domain protein
HB367_RS15440	COG1960	acyl-CoA dehydrogenase activity
HB367_RS15455	COG0408	coproporphyrinogen oxidase activity
HB367_RS15475	COG0513	Belongs to the DEAD box helicase family
HB367_RS15485	COG1127	ABC transporter
HB367_RS15490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB367_RS15500	COG2854	intermembrane phospholipid transfer
HB367_RS15510	COG0598	Magnesium transport protein CorA
HB367_RS15520	COG0494	nUDIX hydrolase
HB367_RS15525	COG1040	competence protein
HB367_RS15530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB367_RS15550	COG1946	Acyl-CoA thioesterase
HB367_RS15555	COG1301	dicarboxylic acid transport
HB367_RS15570	COG1959	2 iron, 2 sulfur cluster binding
HB367_RS15575	COG1017	nitric oxide dioxygenase activity
HB367_RS15575	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_RS15580	COG0433	COG0433 Predicted ATPase
HB367_RS15585	COG0626	cystathionine gamma-synthase activity
HB367_RS15740	COG1960	acyl-CoA dehydrogenase activity
HB367_RS15745	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB367_RS15775	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB367_RS15780	COG0339	signal peptide processing
HB367_RS15785	COG0557	exoribonuclease II activity
HB367_RS15830	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB367_RS15835	COG2169	Transcriptional regulator
HB367_RS15840	COG0697	spore germination
HB367_RS15845	COG1295	ribonuclease BN
HB367_RS15880	COG1702	phosphate starvation-inducible protein PhoH
HB367_RS15890	COG1196	nuclear chromosome segregation
HB367_RS15890	COG0741	lytic transglycosylase activity
HB367_RS15890	COG0739	heme binding
HB367_RS15920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB367_RS15925	COG1183	phosphatidylcholine synthase activity
HB367_RS15970	COG1960	acyl-CoA dehydrogenase activity
HB367_RS15990	COG2969	positive regulation of protein catabolic process
HB367_RS16000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB367_RS16010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB367_RS16015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB367_RS16020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB367_RS16040	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB367_RS16050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB367_RS16055	COG1408	metallophosphoesterase
HB367_RS16065	COG2199	diguanylate cyclase activity
HB367_RS16125	COG1607	acyl-coa hydrolase
HB367_RS16155	COG2350	Protein conserved in bacteria
HB367_RS16165	COG0613	PHP domain protein
HB367_RS16170	COG3781	membrane
HB367_RS16180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB367_RS16185	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB367_RS16195	COG1862	Preprotein translocase
HB367_RS16230	COG2205	protein histidine kinase activity
HB367_RS16235	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB367_RS16255	COG0726	polysaccharide deacetylase
HB367_RS16260	COG0463	Glycosyl transferase, family 2
HB367_RS16265	COG0438	transferase activity, transferring glycosyl groups
HB367_RS16280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB367_RS16290	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS16300	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS16345	COG1960	acyl-CoA dehydrogenase activity
HB367_RS16350	COG1960	acyl-CoA dehydrogenase activity
HB367_RS16360	COG2205	protein histidine kinase activity
HB367_RS16365	COG0745	RESPONSE REGULATOR receiver
HB367_RS16370	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB367_RS16385	COG0584	glycerophosphoryl diester phosphodiesterase
HB367_RS16390	COG2096	Adenosyltransferase
HB367_RS16395	COG4206	TonB-dependent receptor
HB367_RS16440	COG0285	dihydrofolate synthase activity
HB367_RS16460	COG0450	alkyl hydroperoxide reductase
HB367_RS16475	COG0477	Major facilitator Superfamily
HB367_RS16480	COG1272	protein, Hemolysin III
HB367_RS16510	COG0183	Belongs to the thiolase family
HB367_RS16515	COG2207	Transcriptional regulator
HB367_RS16535	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB367_RS16555	COG0183	Belongs to the thiolase family
HB367_RS16565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB367_RS16565	COG2885	chlorophyll binding
HB367_RS16575	COG1690	Belongs to the RtcB family
HB367_RS16580	COG0833	amino acid
HB367_RS16590	COG2233	PERMEase
HB367_RS16620	COG2094	Belongs to the DNA glycosylase MPG family
HB367_RS16625	COG4772	TonB-dependent receptor
HB367_RS16630	COG1902	pentaerythritol trinitrate reductase activity
HB367_RS16635	COG0679	Auxin Efflux Carrier
HB367_RS16645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB367_RS16650	COG0354	folic acid binding
HB367_RS16660	COG3189	MarR family transcriptional regulator
HB367_RS16665	COG2824	Alkylphosphonate utilization operon protein PhnA
HB367_RS16670	COG3422	double-strand break repair
HB367_RS16710	COG0840	transmembrane signaling receptor activity
HB367_RS16730	COG5510	response to toxic substance
HB367_RS16740	COG2832	Protein of unknown function (DUF454)
HB367_RS16745	COG1376	ErfK ybiS ycfS ynhG family protein
HB367_RS16785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB367_RS16795	COG1289	transmembrane transporter activity
HB367_RS16800	COG2814	Major facilitator Superfamily
HB367_RS16820	COG1115	amino acid carrier protein
HB367_RS16825	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB367_RS16830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB367_RS16835	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB367_RS16840	COG3590	peptidase
HB367_RS16865	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB367_RS16875	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB367_RS16880	COG1077	Cell shape determining protein MreB Mrl
HB367_RS16885	COG1792	Involved in formation and maintenance of cell shape
HB367_RS16890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB367_RS16895	COG0424	maF-like protein
HB367_RS16900	COG1530	ribonuclease E activity
HB367_RS16910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_RS16920	COG0560	Phosphoserine phosphatase
HB367_RS16930	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB367_RS16955	COG2207	Transcriptional regulator
HB367_RS17000	COG1113	amino acid transport
HB367_RS17005	COG2828	Protein conserved in bacteria
HB367_RS17010	COG0142	geranyltranstransferase activity
HB367_RS17015	COG2315	Protein conserved in bacteria
HB367_RS17030	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB367_RS17050	COG2194	sulfuric ester hydrolase activity
HB367_RS17055	COG0745	RESPONSE REGULATOR receiver
HB367_RS17060	COG0642	Histidine kinase
HB367_RS17070	COG0004	ammonium transporteR
HB367_RS17075	COG0583	DNA-binding transcription factor activity
HB367_RS17090	COG2226	methyltransferase
HB367_RS17095	COG0525	valine-tRNA ligase activity
HB367_RS17105	COG1028	Short-chain dehydrogenase reductase Sdr
HB367_RS17115	COG0393	Putative heavy-metal-binding
HB367_RS17120	COG0393	Putative heavy-metal-binding
HB367_RS17125	COG1538	Outer membrane efflux protein
HB367_RS17135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS17140	COG0671	phosphoesterase, PA-phosphatase related
HB367_RS17170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB367_RS17185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB367_RS17185	COG1648	precorrin-2 dehydrogenase activity
HB367_RS17190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB367_RS17205	COG0531	amino acid
HB367_RS17220	COG0321	lipoyl(octanoyl) transferase activity
HB367_RS17225	COG2921	Belongs to the UPF0250 family
HB367_RS17260	COG2009	succinate dehydrogenase
HB367_RS17265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB367_RS17270	COG1053	succinate dehydrogenase
HB367_RS17275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB367_RS17300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_RS17320	COG2354	Protein conserved in bacteria
HB367_RS17325	COG2321	neutral zinc metallopeptidase
HB367_RS17345	COG2843	Capsule synthesis protein
HB367_RS17360	COG0589	response to stress
HB367_RS17370	COG0251	oxidation-reduction process
HB367_RS17375	COG1309	transcriptional regulator
HB367_RS17390	COG0505	Belongs to the CarA family
HB367_RS17415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB367_RS17420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB367_RS17470	COG0477	Major facilitator Superfamily
HB367_RS17475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB367_RS17490	COG1597	lipid kinase activity
HB367_RS17495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB367_RS17520	COG0584	glycerophosphoryl diester phosphodiesterase
HB367_RS17540	COG0741	lytic transglycosylase activity
HB367_RS17560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB367_RS17570	COG0582	viral genome integration into host DNA
HB367_RS17595	COG2217	Heavy metal translocating P-type atpase
HB367_RS17600	COG2205	protein histidine kinase activity
HB367_RS17615	COG2132	Multicopper oxidase
HB367_RS17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_RS17655	COG0778	Nitroreductase
HB367_RS17670	COG1929	Belongs to the glycerate kinase type-1 family
HB367_RS17675	COG0243	molybdopterin cofactor binding
HB367_RS17680	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB367_RS17685	COG3339	Conserved Protein
HB367_RS17695	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB367_RS17715	COG1115	amino acid carrier protein
HB367_RS17720	COG1113	amino acid transport
HB367_RS17730	COG0019	diaminopimelate decarboxylase activity
HB367_RS17740	COG2267	carboxylic ester hydrolase activity
HB367_RS17745	COG1280	lysine exporter protein (LysE YggA)
HB367_RS17750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB367_RS17780	COG0463	Glycosyl transferase, family 2
HB367_RS17800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB367_RS17835	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB367_RS17840	COG1136	(ABC) transporter
HB367_RS17845	COG0658	competence protein
HB367_RS17845	COG2333	competence protein COMEC
HB367_RS17855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB367_RS17855	COG0616	signal peptide processing
HB367_RS17860	COG0596	Alpha beta hydrolase
HB367_RS17865	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB367_RS17875	COG0628	permease
HB367_RS17910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB367_RS17930	COG0823	Involved in the tonB-independent uptake of proteins
HB367_RS17950	COG0824	Thioesterase
HB367_RS17955	COG1473	amidohydrolase
HB367_RS17975	COG0047	phosphoribosylformylglycinamidine synthase activity
HB367_RS17975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB367_RS17980	COG2814	Major facilitator Superfamily
HB367_RS17990	COG1024	Enoyl-CoA hydratase
HB367_RS17995	COG1051	belongs to the nudix hydrolase family
HB367_RS17995	COG1056	cytidyltransferase-related domain
HB367_RS18005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB367_RS18020	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB367_RS18035	COG4625	pathogenesis
HB367_RS18040	COG0583	DNA-binding transcription factor activity
HB367_RS18045	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB367_RS18050	COG4208	sulfate ABC transporter
HB367_RS18055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB367_RS18065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB367_RS18070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB367_RS18075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB367_RS18095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB367_RS18110	COG0681	Belongs to the peptidase S26 family
HB367_RS18125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB367_RS18135	COG1381	Involved in DNA repair and RecF pathway recombination
HB367_RS18140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB367_RS18150	COG4221	oxidoreductase activity
HB367_RS18180	COG0443	Heat shock 70 kDa protein
HB367_RS18190	COG0436	Aminotransferase
HB367_RS18210	COG0556	nucleotide-excision repair
HB367_RS18265	COG2070	2-Nitropropane dioxygenase
HB367_RS18295	COG1215	transferase activity, transferring glycosyl groups
HB367_RS18310	COG0415	Belongs to the DNA photolyase family
HB367_RS18320	COG1252	NADH dehydrogenase
HB367_RS18325	COG1686	Belongs to the peptidase S11 family
HB367_RS18340	COG1187	pseudouridine synthase activity
HB367_RS18365	COG0477	Major facilitator Superfamily
HB367_RS18370	COG0583	DNA-binding transcription factor activity
HB367_RS18385	COG0612	Peptidase, M16
HB367_RS18410	COG0352	thiamine-phosphate diphosphorylase activity
HB367_RS18425	COG0564	pseudouridine synthase activity
HB367_RS18430	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS18455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB367_RS18470	COG1309	transcriptional regulator
HB367_RS18480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB367_RS18485	COG0076	glutamate decarboxylase activity
HB367_RS18495	COG1522	sequence-specific DNA binding
HB367_RS18500	COG3961	Belongs to the TPP enzyme family
HB367_RS18505	COG1113	amino acid transport
HB367_RS18510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB367_RS18515	COG0573	inorganic phosphate transmembrane transporter activity
HB367_RS18525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB367_RS18530	COG0616	signal peptide processing
HB367_RS18565	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB367_RS18570	COG1686	Belongs to the peptidase S11 family
HB367_RS18595	COG0583	DNA-binding transcription factor activity
HB367_RS18600	COG1067	ATP-dependent peptidase activity
HB367_RS18625	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HB367_RS18645	COG1966	Carbon starvation protein
HB367_RS18650	COG2879	small protein
HB367_RS18675	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS18695	COG1741	Belongs to the pirin family
HB367_RS18705	COG2964	Protein conserved in bacteria
HB367_RS18720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_RS18725	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB367_RS18730	COG4605	iron ion homeostasis
HB367_RS18735	COG4604	ABC transporter, ATP-binding protein
HB367_RS18740	COG4607	ABC-type enterochelin transport system periplasmic component
HB367_RS18745	COG4774	siderophore transport
HB367_RS18755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB367_RS18760	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB367_RS18765	COG1535	isochorismatase
HB367_RS18765	COG3433	isochorismatase activity
HB367_RS18780	COG1132	(ABC) transporter
HB367_RS18785	COG5265	(ABC) transporter
HB367_RS18790	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB367_RS18810	COG1169	isochorismate synthase
HB367_RS18825	COG3739	integral membrane protein
HB367_RS18855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB367_RS18885	COG0308	aminopeptidase N
HB367_RS18890	COG0512	Glutamine amidotransferase of anthranilate synthase
HB367_RS18900	COG3104	oligopeptide transport
HB367_RS18905	COG0174	glutamine synthetase
HB367_RS18915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB367_RS18950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB367_RS18955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB367_RS18960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB367_RS18980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB367_RS18985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB367_RS18990	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB367_RS19005	COG1960	acyl-CoA dehydrogenase activity
HB367_RS19010	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB367_RS19015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB367_RS19025	COG2223	nitrite transmembrane transporter activity
HB367_RS19035	COG0024	Methionine aminopeptidase
HB367_RS19040	COG0052	Belongs to the universal ribosomal protein uS2 family
HB367_RS19055	COG2207	Transcriptional regulator
HB367_RS19065	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS19090	COG2951	lytic endotransglycosylase activity
HB367_RS19095	COG0772	Belongs to the SEDS family
HB367_RS19110	COG0842	Transport permease protein
HB367_RS19115	COG1131	(ABC) transporter
HB367_RS19135	COG3173	Aminoglycoside phosphotransferase
HB367_RS19155	COG0482	sulfurtransferase activity
HB367_RS19280	COG1192	Involved in chromosome partitioning
HB367_RS19305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_RS19325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB367_RS19330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB367_RS19375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB367_RS19430	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS19455	COG1324	tolerance protein
HB367_RS19460	COG0673	inositol 2-dehydrogenase activity
HB367_RS19480	COG2826	transposase and inactivated derivatives, IS30 family
HB367_RS19520	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB367_RS19570	COG1192	Involved in chromosome partitioning
HB367_RS19580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB367_RS19625	COG0739	heme binding
HB367_RS19850	COG0501	Belongs to the peptidase M48B family
HB367_RS19885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB367_RS19935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB367_RS20005	COG3561	AntA/AntB antirepressor
HB367_RS20060	COG3179	chitinase
HB367_RS20070	COG0582	viral genome integration into host DNA
HB367_RS20075	COG3617	BRO family, N-terminal domain
HB367_RS20115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB367_RS20170	COG0305	Participates in initiation and elongation during chromosome replication
HB367_RS20285	COG5410	chromosome segregation
HB367_RS20440	COG2832	Protein of unknown function (DUF454)
HB367_RS20500	COG4683	PFAM Phage derived protein Gp49-like (DUF891)