locus-tag	class	description
HB368_RS00010	COG0592	DNA-directed DNA polymerase activity
HB368_RS00020	COG0187	DNA topoisomerase II activity
HB368_RS00030	COG0586	Pfam SNARE associated Golgi protein
HB368_RS00035	COG0488	(ABC) transporter
HB368_RS00060	COG0596	Alpha beta hydrolase
HB368_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB368_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB368_RS00115	COG0733	neurotransmitter:sodium symporter activity
HB368_RS00150	COG0583	DNA-binding transcription factor activity
HB368_RS00155	COG2233	PERMEase
HB368_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS00205	COG2814	Major facilitator Superfamily
HB368_RS00210	COG0656	L-ascorbic acid biosynthetic process
HB368_RS00215	COG0583	DNA-binding transcription factor activity
HB368_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS00235	COG1064	alcohol dehydrogenase
HB368_RS00240	COG2818	Glycosylase
HB368_RS00255	COG1194	a g-specific adenine glycosylase
HB368_RS00275	COG2983	Belongs to the UPF0260 family
HB368_RS00280	COG2133	pyrroloquinoline quinone binding
HB368_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB368_RS00290	COG2116	formate transmembrane transporter activity
HB368_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB368_RS00315	COG1335	isochorismatase
HB368_RS00320	COG0385	Bile acid
HB368_RS00325	COG0534	Mate efflux family protein
HB368_RS00330	COG1683	Conserved Protein
HB368_RS00350	COG0625	glutathione transferase activity
HB368_RS00360	COG1113	amino acid transport
HB368_RS00370	COG0523	cobalamin synthesis protein
HB368_RS00380	COG2188	Transcriptional regulator
HB368_RS00410	COG0010	Belongs to the arginase family
HB368_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB368_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB368_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB368_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB368_RS00535	COG0436	Aminotransferase
HB368_RS00540	COG2733	membrane
HB368_RS00555	COG2918	glutathione biosynthetic process
HB368_RS00625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB368_RS00640	COG3501	Rhs element vgr protein
HB368_RS00700	COG3150	esterase
HB368_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS00715	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB368_RS00725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB368_RS00740	COG2233	PERMEase
HB368_RS00745	COG2351	hydroxyisourate hydrolase activity
HB368_RS00780	COG3706	GGDEF domain
HB368_RS00795	COG1393	Belongs to the ArsC family
HB368_RS00800	COG0708	Exodeoxyribonuclease III
HB368_RS00825	COG0189	ligase activity
HB368_RS00845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB368_RS00855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB368_RS00870	COG4942	peptidase
HB368_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB368_RS00890	COG2119	membrane
HB368_RS00895	COG4774	siderophore transport
HB368_RS00900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB368_RS00900	COG0426	domain, Protein
HB368_RS00925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB368_RS00945	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS00950	COG1519	Transferase
HB368_RS00955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB368_RS00960	COG0668	transmembrane transport
HB368_RS00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB368_RS00975	COG1335	isochorismatase
HB368_RS00980	COG1522	sequence-specific DNA binding
HB368_RS01005	COG0784	Response regulator, receiver
HB368_RS01005	COG2198	Histidine kinase
HB368_RS01005	COG2205	protein histidine kinase activity
HB368_RS01010	COG3162	membrane
HB368_RS01015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB368_RS01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB368_RS01035	COG3706	GGDEF domain
HB368_RS01040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB368_RS01045	COG1309	transcriptional regulator
HB368_RS01065	COG0352	thiamine-phosphate diphosphorylase activity
HB368_RS01065	COG0351	phosphomethylpyrimidine kinase
HB368_RS01065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB368_RS01075	COG2814	Major facilitator Superfamily
HB368_RS01090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB368_RS01100	COG1113	amino acid transport
HB368_RS01110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB368_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS01125	COG1335	isochorismatase
HB368_RS01155	COG2814	Major facilitator Superfamily
HB368_RS01160	COG0583	DNA-binding transcription factor activity
HB368_RS01215	COG0667	Aldo Keto reductase
HB368_RS01235	COG1129	ABC transporter
HB368_RS01245	COG2207	Transcriptional regulator
HB368_RS01300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB368_RS01315	COG2329	Antibiotic biosynthesis monooxygenase
HB368_RS01330	COG1132	(ABC) transporter
HB368_RS01350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB368_RS01380	COG0427	acetyl-CoA hydrolase
HB368_RS01395	COG0745	RESPONSE REGULATOR receiver
HB368_RS01405	COG0659	secondary active sulfate transmembrane transporter activity
HB368_RS01410	COG4221	oxidoreductase activity
HB368_RS01420	COG0488	(ABC) transporter
HB368_RS01485	COG0833	amino acid
HB368_RS01530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB368_RS01535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB368_RS01550	COG2226	methyltransferase
HB368_RS01600	COG0069	glutamate synthase activity
HB368_RS01600	COG0070	glutamate synthase
HB368_RS01600	COG0067	glutamate synthase
HB368_RS01605	COG0493	'glutamate synthase
HB368_RS01615	COG1704	LemA family
HB368_RS01620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB368_RS01640	COG3307	-O-antigen
HB368_RS01660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB368_RS01675	COG0194	GDP metabolic process
HB368_RS01725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB368_RS01745	COG5380	lipid catabolic process
HB368_RS01750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB368_RS01775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB368_RS01780	COG0277	FAD linked oxidase domain protein
HB368_RS01790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB368_RS01795	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB368_RS01810	COG1289	transmembrane transporter activity
HB368_RS01820	COG0628	permease
HB368_RS01825	COG1192	Involved in chromosome partitioning
HB368_RS01855	COG0833	amino acid
HB368_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB368_RS01865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB368_RS01875	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS01915	COG0583	DNA-binding transcription factor activity
HB368_RS01975	COG0517	IMP dehydrogenase activity
HB368_RS01980	COG1983	PspC domain protein
HB368_RS01990	COG1960	acyl-CoA dehydrogenase activity
HB368_RS02005	COG0408	coproporphyrinogen oxidase activity
HB368_RS02025	COG0513	Belongs to the DEAD box helicase family
HB368_RS02035	COG1127	ABC transporter
HB368_RS02040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB368_RS02050	COG2854	intermembrane phospholipid transfer
HB368_RS02060	COG0598	Magnesium transport protein CorA
HB368_RS02070	COG0494	nUDIX hydrolase
HB368_RS02075	COG1040	competence protein
HB368_RS02080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB368_RS02100	COG1946	Acyl-CoA thioesterase
HB368_RS02105	COG1301	dicarboxylic acid transport
HB368_RS02120	COG1959	2 iron, 2 sulfur cluster binding
HB368_RS02125	COG1017	nitric oxide dioxygenase activity
HB368_RS02125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB368_RS02130	COG0433	COG0433 Predicted ATPase
HB368_RS02135	COG0626	cystathionine gamma-synthase activity
HB368_RS02290	COG1960	acyl-CoA dehydrogenase activity
HB368_RS02295	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB368_RS02325	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB368_RS02330	COG0339	signal peptide processing
HB368_RS02335	COG0557	exoribonuclease II activity
HB368_RS02380	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB368_RS02385	COG2169	Transcriptional regulator
HB368_RS02390	COG0697	spore germination
HB368_RS02395	COG1295	ribonuclease BN
HB368_RS02430	COG1702	phosphate starvation-inducible protein PhoH
HB368_RS02440	COG0739	heme binding
HB368_RS02440	COG1196	nuclear chromosome segregation
HB368_RS02440	COG0741	lytic transglycosylase activity
HB368_RS02470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB368_RS02475	COG1183	phosphatidylcholine synthase activity
HB368_RS02520	COG1960	acyl-CoA dehydrogenase activity
HB368_RS02540	COG2969	positive regulation of protein catabolic process
HB368_RS02550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB368_RS02560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB368_RS02565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB368_RS02570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB368_RS02590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB368_RS02600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB368_RS02605	COG1408	metallophosphoesterase
HB368_RS02615	COG2199	diguanylate cyclase activity
HB368_RS02675	COG1607	acyl-coa hydrolase
HB368_RS02705	COG2350	Protein conserved in bacteria
HB368_RS02715	COG0613	PHP domain protein
HB368_RS02720	COG3781	membrane
HB368_RS02730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB368_RS02735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB368_RS02745	COG1862	Preprotein translocase
HB368_RS02780	COG2205	protein histidine kinase activity
HB368_RS02785	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB368_RS02805	COG0726	polysaccharide deacetylase
HB368_RS02810	COG0463	Glycosyl transferase, family 2
HB368_RS02815	COG0438	transferase activity, transferring glycosyl groups
HB368_RS02830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB368_RS02840	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS02850	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS02895	COG1960	acyl-CoA dehydrogenase activity
HB368_RS02900	COG1960	acyl-CoA dehydrogenase activity
HB368_RS02910	COG2205	protein histidine kinase activity
HB368_RS02915	COG0745	RESPONSE REGULATOR receiver
HB368_RS02920	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB368_RS02935	COG0584	glycerophosphoryl diester phosphodiesterase
HB368_RS02940	COG2096	Adenosyltransferase
HB368_RS02945	COG4206	TonB-dependent receptor
HB368_RS02990	COG0285	dihydrofolate synthase activity
HB368_RS03010	COG0450	alkyl hydroperoxide reductase
HB368_RS03025	COG0477	Major facilitator Superfamily
HB368_RS03030	COG1272	protein, Hemolysin III
HB368_RS03060	COG0183	Belongs to the thiolase family
HB368_RS03065	COG2207	Transcriptional regulator
HB368_RS03085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB368_RS03105	COG0183	Belongs to the thiolase family
HB368_RS03115	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB368_RS03115	COG2885	chlorophyll binding
HB368_RS03125	COG1690	Belongs to the RtcB family
HB368_RS03130	COG0833	amino acid
HB368_RS03140	COG2233	PERMEase
HB368_RS03170	COG2094	Belongs to the DNA glycosylase MPG family
HB368_RS03175	COG4772	TonB-dependent receptor
HB368_RS03180	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS03195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB368_RS03200	COG0354	folic acid binding
HB368_RS03210	COG3189	MarR family transcriptional regulator
HB368_RS03215	COG2824	Alkylphosphonate utilization operon protein PhnA
HB368_RS03220	COG3422	double-strand break repair
HB368_RS03235	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS03270	COG0840	transmembrane signaling receptor activity
HB368_RS03290	COG5510	response to toxic substance
HB368_RS03300	COG2832	Protein of unknown function (DUF454)
HB368_RS03305	COG1376	ErfK ybiS ycfS ynhG family protein
HB368_RS03345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB368_RS03355	COG1289	transmembrane transporter activity
HB368_RS03360	COG2814	Major facilitator Superfamily
HB368_RS03380	COG1115	amino acid carrier protein
HB368_RS03385	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB368_RS03390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB368_RS03395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB368_RS03400	COG3590	peptidase
HB368_RS03425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB368_RS03435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB368_RS03440	COG1077	Cell shape determining protein MreB Mrl
HB368_RS03445	COG1792	Involved in formation and maintenance of cell shape
HB368_RS03450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB368_RS03455	COG0424	maF-like protein
HB368_RS03460	COG1530	ribonuclease E activity
HB368_RS03470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB368_RS03480	COG0560	Phosphoserine phosphatase
HB368_RS03490	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB368_RS03515	COG2207	Transcriptional regulator
HB368_RS03560	COG1113	amino acid transport
HB368_RS03565	COG2828	Protein conserved in bacteria
HB368_RS03570	COG0142	geranyltranstransferase activity
HB368_RS03575	COG2315	Protein conserved in bacteria
HB368_RS03590	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB368_RS03610	COG2194	sulfuric ester hydrolase activity
HB368_RS03615	COG0745	RESPONSE REGULATOR receiver
HB368_RS03620	COG0642	Histidine kinase
HB368_RS03630	COG0004	ammonium transporteR
HB368_RS03635	COG0583	DNA-binding transcription factor activity
HB368_RS03650	COG2226	methyltransferase
HB368_RS03655	COG0525	valine-tRNA ligase activity
HB368_RS03665	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS03675	COG0393	Putative heavy-metal-binding
HB368_RS03680	COG0393	Putative heavy-metal-binding
HB368_RS03685	COG1538	Outer membrane efflux protein
HB368_RS03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS03700	COG0671	phosphoesterase, PA-phosphatase related
HB368_RS03730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB368_RS03745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB368_RS03745	COG1648	precorrin-2 dehydrogenase activity
HB368_RS03750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB368_RS03765	COG0531	amino acid
HB368_RS03780	COG0321	lipoyl(octanoyl) transferase activity
HB368_RS03785	COG2921	Belongs to the UPF0250 family
HB368_RS03820	COG2009	succinate dehydrogenase
HB368_RS03825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB368_RS03830	COG1053	succinate dehydrogenase
HB368_RS03835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB368_RS03860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB368_RS03880	COG2354	Protein conserved in bacteria
HB368_RS03885	COG2321	neutral zinc metallopeptidase
HB368_RS03905	COG2843	Capsule synthesis protein
HB368_RS03920	COG0589	response to stress
HB368_RS03930	COG0251	oxidation-reduction process
HB368_RS03935	COG1309	transcriptional regulator
HB368_RS03950	COG0505	Belongs to the CarA family
HB368_RS03975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB368_RS03980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB368_RS04030	COG0477	Major facilitator Superfamily
HB368_RS04035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB368_RS04050	COG1597	lipid kinase activity
HB368_RS04055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB368_RS04080	COG0584	glycerophosphoryl diester phosphodiesterase
HB368_RS04100	COG0741	lytic transglycosylase activity
HB368_RS04120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB368_RS04130	COG0582	viral genome integration into host DNA
HB368_RS04155	COG2217	Heavy metal translocating P-type atpase
HB368_RS04160	COG2205	protein histidine kinase activity
HB368_RS04175	COG2132	Multicopper oxidase
HB368_RS04200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB368_RS04215	COG0778	Nitroreductase
HB368_RS04230	COG1929	Belongs to the glycerate kinase type-1 family
HB368_RS04235	COG0243	molybdopterin cofactor binding
HB368_RS04240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB368_RS04245	COG3339	Conserved Protein
HB368_RS04255	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB368_RS04275	COG1115	amino acid carrier protein
HB368_RS04280	COG1113	amino acid transport
HB368_RS04290	COG0019	diaminopimelate decarboxylase activity
HB368_RS04300	COG2267	carboxylic ester hydrolase activity
HB368_RS04305	COG1280	lysine exporter protein (LysE YggA)
HB368_RS04310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB368_RS04340	COG0463	Glycosyl transferase, family 2
HB368_RS04360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS04395	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB368_RS04400	COG1136	(ABC) transporter
HB368_RS04405	COG0658	competence protein
HB368_RS04405	COG2333	competence protein COMEC
HB368_RS04415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB368_RS04415	COG0616	signal peptide processing
HB368_RS04420	COG0596	Alpha beta hydrolase
HB368_RS04425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB368_RS04435	COG0628	permease
HB368_RS04470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB368_RS04490	COG0823	Involved in the tonB-independent uptake of proteins
HB368_RS04510	COG0824	Thioesterase
HB368_RS04515	COG1473	amidohydrolase
HB368_RS04535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB368_RS04535	COG0047	phosphoribosylformylglycinamidine synthase activity
HB368_RS04540	COG2814	Major facilitator Superfamily
HB368_RS04550	COG1024	Enoyl-CoA hydratase
HB368_RS04555	COG1056	cytidyltransferase-related domain
HB368_RS04555	COG1051	belongs to the nudix hydrolase family
HB368_RS04565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB368_RS04580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB368_RS04595	COG4625	pathogenesis
HB368_RS04600	COG0583	DNA-binding transcription factor activity
HB368_RS04605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB368_RS04610	COG4208	sulfate ABC transporter
HB368_RS04615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB368_RS04625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB368_RS04630	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB368_RS04635	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB368_RS04655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB368_RS04670	COG0681	Belongs to the peptidase S26 family
HB368_RS04685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB368_RS04695	COG1381	Involved in DNA repair and RecF pathway recombination
HB368_RS04700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB368_RS04710	COG4221	oxidoreductase activity
HB368_RS04740	COG0443	Heat shock 70 kDa protein
HB368_RS04750	COG0436	Aminotransferase
HB368_RS04770	COG0556	nucleotide-excision repair
HB368_RS04825	COG2070	2-Nitropropane dioxygenase
HB368_RS04855	COG1215	transferase activity, transferring glycosyl groups
HB368_RS04870	COG0415	Belongs to the DNA photolyase family
HB368_RS04880	COG1252	NADH dehydrogenase
HB368_RS04885	COG1686	Belongs to the peptidase S11 family
HB368_RS04900	COG1187	pseudouridine synthase activity
HB368_RS04925	COG0477	Major facilitator Superfamily
HB368_RS04930	COG0583	DNA-binding transcription factor activity
HB368_RS04945	COG0612	Peptidase, M16
HB368_RS04970	COG0352	thiamine-phosphate diphosphorylase activity
HB368_RS04985	COG0564	pseudouridine synthase activity
HB368_RS04990	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS05015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB368_RS05030	COG1309	transcriptional regulator
HB368_RS05040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB368_RS05045	COG0076	glutamate decarboxylase activity
HB368_RS05055	COG1522	sequence-specific DNA binding
HB368_RS05060	COG3961	Belongs to the TPP enzyme family
HB368_RS05065	COG1113	amino acid transport
HB368_RS05070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB368_RS05075	COG0573	inorganic phosphate transmembrane transporter activity
HB368_RS05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB368_RS05090	COG0616	signal peptide processing
HB368_RS05125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB368_RS05130	COG1686	Belongs to the peptidase S11 family
HB368_RS05155	COG0583	DNA-binding transcription factor activity
HB368_RS05160	COG1067	ATP-dependent peptidase activity
HB368_RS05185	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HB368_RS05205	COG1966	Carbon starvation protein
HB368_RS05210	COG2879	small protein
HB368_RS05235	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS05255	COG1741	Belongs to the pirin family
HB368_RS05265	COG2964	Protein conserved in bacteria
HB368_RS05280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB368_RS05285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB368_RS05290	COG4605	iron ion homeostasis
HB368_RS05295	COG4604	ABC transporter, ATP-binding protein
HB368_RS05300	COG4607	ABC-type enterochelin transport system periplasmic component
HB368_RS05305	COG4774	siderophore transport
HB368_RS05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB368_RS05320	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB368_RS05325	COG3433	isochorismatase activity
HB368_RS05325	COG1535	isochorismatase
HB368_RS05340	COG1132	(ABC) transporter
HB368_RS05345	COG5265	(ABC) transporter
HB368_RS05350	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB368_RS05370	COG1169	isochorismate synthase
HB368_RS05385	COG3739	integral membrane protein
HB368_RS05425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB368_RS05455	COG0308	aminopeptidase N
HB368_RS05460	COG0512	Glutamine amidotransferase of anthranilate synthase
HB368_RS05470	COG3104	oligopeptide transport
HB368_RS05475	COG0174	glutamine synthetase
HB368_RS05485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB368_RS05520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB368_RS05525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB368_RS05530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB368_RS05550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB368_RS05555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB368_RS05560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB368_RS05575	COG1960	acyl-CoA dehydrogenase activity
HB368_RS05580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB368_RS05585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB368_RS05595	COG2223	nitrite transmembrane transporter activity
HB368_RS05615	COG0024	Methionine aminopeptidase
HB368_RS05620	COG0052	Belongs to the universal ribosomal protein uS2 family
HB368_RS05635	COG2207	Transcriptional regulator
HB368_RS05645	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS05670	COG2951	lytic endotransglycosylase activity
HB368_RS05675	COG0772	Belongs to the SEDS family
HB368_RS05690	COG0842	Transport permease protein
HB368_RS05695	COG1131	(ABC) transporter
HB368_RS05700	COG0582	viral genome integration into host DNA
HB368_RS05705	COG3617	BRO family, N-terminal domain
HB368_RS05745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB368_RS05800	COG0305	Participates in initiation and elongation during chromosome replication
HB368_RS05915	COG5410	chromosome segregation
HB368_RS06025	COG3561	AntA/AntB antirepressor
HB368_RS06080	COG3179	chitinase
HB368_RS06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS06145	COG4215	(ABC) transporter
HB368_RS06150	COG4160	amino acid transport
HB368_RS06155	COG4598	ABC transporter
HB368_RS06165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB368_RS06175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS06180	COG0384	phenazine biosynthesis protein PhzF
HB368_RS06190	COG1720	tRNA m6t6A37 methyltransferase activity
HB368_RS06210	COG0745	RESPONSE REGULATOR receiver
HB368_RS06215	COG0642	Histidine kinase
HB368_RS06225	COG0494	nUDIX hydrolase
HB368_RS06235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB368_RS06240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB368_RS06245	COG3139	Protein of unknown function (DUF1315)
HB368_RS06250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB368_RS06255	COG1301	dicarboxylic acid transport
HB368_RS06260	COG1960	acyl-CoA dehydrogenase activity
HB368_RS06275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB368_RS06285	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB368_RS06305	COG1690	Belongs to the RtcB family
HB368_RS06310	COG1234	tRNA 3'-trailer cleavage
HB368_RS06315	COG4650	regulator
HB368_RS06345	COG2363	Small membrane protein
HB368_RS06365	COG0513	Belongs to the DEAD box helicase family
HB368_RS06375	COG0778	Nitroreductase
HB368_RS06510	COG1286	toxin biosynthetic process
HB368_RS06535	COG4783	chaperone-mediated protein folding
HB368_RS06540	COG1610	YqeY-like protein
HB368_RS06640	COG3111	PFAM Bacterial OB fold (BOF) protein
HB368_RS06665	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB368_RS06670	COG0786	glutamate:sodium symporter activity
HB368_RS06680	COG2186	Transcriptional regulator
HB368_RS06685	COG1051	belongs to the nudix hydrolase family
HB368_RS06715	COG2995	paraquat-inducible protein a
HB368_RS06720	COG3008	intermembrane lipid transfer
HB368_RS06720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB368_RS06730	COG2351	hydroxyisourate hydrolase activity
HB368_RS06770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB368_RS06780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB368_RS06785	COG0642	Histidine kinase
HB368_RS06790	COG0745	RESPONSE REGULATOR receiver
HB368_RS06810	COG1794	racemase activity, acting on amino acids and derivatives
HB368_RS06840	COG1301	dicarboxylic acid transport
HB368_RS06850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB368_RS06855	COG2011	ABC-type metal ion transport system permease component
HB368_RS06860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB368_RS06865	COG1464	Belongs to the NlpA lipoprotein family
HB368_RS06870	COG0151	Belongs to the GarS family
HB368_RS06875	COG0138	bifunctional purine biosynthesis protein purh
HB368_RS06880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB368_RS06910	COG2308	Evidence 4 Homologs of previously reported genes of
HB368_RS06920	COG1305	Transglutaminase-like
HB368_RS06930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB368_RS06935	COG0305	Participates in initiation and elongation during chromosome replication
HB368_RS06960	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB368_RS06970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB368_RS06975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB368_RS07000	COG0726	polysaccharide deacetylase
HB368_RS07000	COG1649	PFAM Uncharacterised BCR, COG1649
HB368_RS07005	COG1215	transferase activity, transferring glycosyl groups
HB368_RS07010	COG3658	cytochrome
HB368_RS07020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB368_RS07035	COG0583	DNA-binding transcription factor activity
HB368_RS07065	COG1960	acyl-CoA dehydrogenase activity
HB368_RS07070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB368_RS07075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB368_RS07100	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB368_RS07105	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB368_RS07110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB368_RS07115	COG2205	protein histidine kinase activity
HB368_RS07120	COG0745	RESPONSE REGULATOR receiver
HB368_RS07125	COG0174	glutamine synthetase
HB368_RS07145	COG0729	surface antigen
HB368_RS07270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB368_RS07275	COG2814	Major facilitator Superfamily
HB368_RS07290	COG0583	DNA-binding transcription factor activity
HB368_RS07305	COG1187	pseudouridine synthase activity
HB368_RS07325	COG0802	atpase or kinase
HB368_RS07330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB368_RS07340	COG1923	regulation of RNA biosynthetic process
HB368_RS07345	COG0697	spore germination
HB368_RS07360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB368_RS07370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB368_RS07375	COG0519	Catalyzes the synthesis of GMP from XMP
HB368_RS07375	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB368_RS07380	COG4302	ethanolamine ammonia-lyase activity
HB368_RS07385	COG4303	Ethanolamine ammonia lyase large subunit
HB368_RS07390	COG0531	amino acid
HB368_RS07410	COG1454	alcohol dehydrogenase
HB368_RS07415	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB368_RS07440	COG0308	aminopeptidase N
HB368_RS07480	COG1605	Chorismate mutase
HB368_RS07495	COG1309	transcriptional regulator
HB368_RS07505	COG0668	transmembrane transport
HB368_RS07535	COG3328	transposase activity
HB368_RS07545	COG4773	Receptor
HB368_RS07565	COG0488	(ABC) transporter
HB368_RS07570	COG0589	response to stress
HB368_RS07595	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB368_RS07605	COG3135	benzoate transporter
HB368_RS07610	COG1522	sequence-specific DNA binding
HB368_RS07620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB368_RS07625	COG0583	DNA-binding transcription factor activity
HB368_RS07635	COG0183	Belongs to the thiolase family
HB368_RS07645	COG2030	dehydratase
HB368_RS07675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB368_RS07685	COG0824	Thioesterase
HB368_RS07690	COG1454	alcohol dehydrogenase
HB368_RS07700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB368_RS07730	COG0069	glutamate synthase activity
HB368_RS07885	COG5410	chromosome segregation
HB368_RS07985	COG1598	PFAM Uncharacterised protein family UPF0150
HB368_RS08035	COG3179	chitinase
HB368_RS08045	COG1063	alcohol dehydrogenase
HB368_RS08050	COG3293	Transposase
HB368_RS08080	COG2814	Major facilitator Superfamily
HB368_RS08095	COG0511	ligase activity, forming carbon-carbon bonds
HB368_RS08115	COG1116	anion transmembrane transporter activity
HB368_RS08115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB368_RS08120	COG0745	RESPONSE REGULATOR receiver
HB368_RS08130	COG2146	nitrite reductase [NAD(P)H] activity
HB368_RS08130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB368_RS08135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB368_RS08140	COG0243	molybdopterin cofactor binding
HB368_RS08155	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB368_RS08170	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB368_RS08170	COG0315	cyclic pyranopterin monophosphate synthase activity
HB368_RS08175	COG0303	'Molybdopterin
HB368_RS08185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS08190	COG0697	spore germination
HB368_RS08210	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB368_RS08215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB368_RS08270	COG2204	response regulator
HB368_RS08275	COG3852	Histidine kinase
HB368_RS08300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB368_RS08305	COG0575	Belongs to the CDS family
HB368_RS08320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB368_RS08340	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB368_RS08355	COG2137	regulation of response to DNA damage stimulus
HB368_RS08365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB368_RS08370	COG1011	Hydrolase
HB368_RS08395	COG1522	sequence-specific DNA binding
HB368_RS08405	COG1113	amino acid transport
HB368_RS08420	COG0659	secondary active sulfate transmembrane transporter activity
HB368_RS08425	COG2135	peptidase activity
HB368_RS08440	COG5001	Diguanylate cyclase
HB368_RS08440	COG3300	MHYT domain
HB368_RS08455	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB368_RS08455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB368_RS08455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB368_RS08460	COG1105	Belongs to the carbohydrate kinase PfkB family
HB368_RS08465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB368_RS08465	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB368_RS08495	COG0024	Methionine aminopeptidase
HB368_RS08500	COG0583	DNA-binding transcription factor activity
HB368_RS08510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB368_RS08515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB368_RS08520	COG0516	GMP reductase activity
HB368_RS08520	COG0517	IMP dehydrogenase activity
HB368_RS08545	COG0552	protein localization to endoplasmic reticulum
HB368_RS08555	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HB368_RS08570	COG4890	Cyd operon protein YbgT
HB368_RS08575	COG1294	oxidase, subunit
HB368_RS08590	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS08595	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB368_RS08605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB368_RS08610	COG4774	siderophore transport
HB368_RS08625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB368_RS08630	COG0569	domain protein
HB368_RS08635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB368_RS08670	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB368_RS08675	COG0542	response to heat
HB368_RS08700	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS08700	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB368_RS08745	COG2323	membrane
HB368_RS08750	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB368_RS08760	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB368_RS08765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB368_RS08770	COG0183	Belongs to the thiolase family
HB368_RS08775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB368_RS08780	COG0596	Alpha beta hydrolase
HB368_RS08785	COG2271	Major facilitator Superfamily
HB368_RS08790	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB368_RS08795	COG3485	protocatechuate 3,4-dioxygenase
HB368_RS08800	COG3485	protocatechuate 3,4-dioxygenase
HB368_RS08805	COG0710	3-dehydroquinate dehydratase activity
HB368_RS08810	COG3420	alginic acid biosynthetic process
HB368_RS08815	COG3659	wide pore channel activity
HB368_RS08820	COG4993	Dehydrogenase
HB368_RS08830	COG2391	methyltransferase activity
HB368_RS08845	COG1414	Transcriptional regulator
HB368_RS08850	COG0583	DNA-binding transcription factor activity
HB368_RS08855	COG1960	acyl-CoA dehydrogenase activity
HB368_RS08880	COG2814	Major facilitator Superfamily
HB368_RS08890	COG0154	amidase activity
HB368_RS08910	COG4638	Rieske (2fe-2S)
HB368_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS08930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB368_RS08940	COG3733	amine oxidase
HB368_RS08950	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS08960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB368_RS08965	COG0183	Belongs to the thiolase family
HB368_RS08970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB368_RS08975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB368_RS08985	COG4829	muconolactone delta-isomerase
HB368_RS08990	COG4948	Mandelate Racemase Muconate Lactonizing
HB368_RS08995	COG0583	DNA-binding transcription factor activity
HB368_RS09005	COG2186	Transcriptional regulator
HB368_RS09025	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS09040	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS09040	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB368_RS09080	COG1309	transcriptional regulator
HB368_RS09085	COG0583	DNA-binding transcription factor activity
HB368_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09095	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09100	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09110	COG1960	acyl-CoA dehydrogenase activity
HB368_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
HB368_RS09165	COG2188	Transcriptional regulator
HB368_RS09180	COG0583	DNA-binding transcription factor activity
HB368_RS09205	COG1566	PFAM secretion protein HlyD family protein
HB368_RS09220	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS09225	COG0129	dihydroxy-acid dehydratase activity
HB368_RS09235	COG0583	DNA-binding transcription factor activity
HB368_RS09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HB368_RS09250	COG2084	Dehydrogenase
HB368_RS09270	COG1120	ATPase activity
HB368_RS09290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB368_RS09345	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB368_RS09360	COG0556	nucleotide-excision repair
HB368_RS09395	COG1073	alpha beta
HB368_RS09405	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09420	COG2207	Transcriptional regulator
HB368_RS09430	COG2205	protein histidine kinase activity
HB368_RS09435	COG0745	RESPONSE REGULATOR receiver
HB368_RS09440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS09445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB368_RS09450	COG1538	Outer membrane efflux protein
HB368_RS09460	COG2072	flavoprotein involved in K transport
HB368_RS09475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HB368_RS09495	COG3539	Fimbrial protein
HB368_RS09520	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB368_RS09530	COG0753	catalase activity
HB368_RS09545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB368_RS09610	COG3433	isochorismatase activity
HB368_RS09610	COG1535	isochorismatase
HB368_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB368_RS09625	COG4149	molybdate abc transporter
HB368_RS09630	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB368_RS09640	COG4638	Rieske (2fe-2S)
HB368_RS09645	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB368_RS09650	COG0543	2 iron, 2 sulfur cluster binding
HB368_RS09650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB368_RS09665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB368_RS09680	COG3328	transposase activity
HB368_RS09700	COG2207	Transcriptional regulator
HB368_RS09705	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS09710	COG2610	gluconate transmembrane transporter activity
HB368_RS09720	COG0583	DNA-binding transcription factor activity
HB368_RS09735	COG2031	fatty acid transporter
HB368_RS09740	COG0183	Belongs to the thiolase family
HB368_RS09745	COG0583	DNA-binding transcription factor activity
HB368_RS09750	COG0583	DNA-binding transcription factor activity
HB368_RS09765	COG1027	Aspartate ammonia-lyase
HB368_RS09775	COG0477	Major facilitator Superfamily
HB368_RS09795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB368_RS09800	COG4521	taurine ABC transporter
HB368_RS09815	COG2188	Transcriptional regulator
HB368_RS09825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB368_RS09830	COG1733	regulation of RNA biosynthetic process
HB368_RS09835	COG2207	Transcriptional regulator
HB368_RS09835	COG3708	Transcriptional regulator
HB368_RS09850	COG0730	response to heat
HB368_RS09860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB368_RS09860	COG3453	Protein conserved in bacteria
HB368_RS09870	COG3781	membrane
HB368_RS09875	COG1063	alcohol dehydrogenase
HB368_RS09885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB368_RS09890	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB368_RS09895	COG0022	dehydrogenase e1 component
HB368_RS09900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB368_RS09910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB368_RS09925	COG3706	GGDEF domain
HB368_RS09940	COG0133	tryptophan synthase activity
HB368_RS09950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB368_RS09985	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB368_RS10010	COG2226	methyltransferase
HB368_RS10035	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS10045	COG0537	adenosine 5'-monophosphoramidase activity
HB368_RS10070	COG0842	Transport permease protein
HB368_RS10075	COG0842	Transport permease protein
HB368_RS10080	COG1131	(ABC) transporter
HB368_RS10095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB368_RS10100	COG4773	Receptor
HB368_RS10120	COG0730	response to heat
HB368_RS10125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB368_RS10140	COG0406	alpha-ribazole phosphatase activity
HB368_RS10145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB368_RS10190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB368_RS10200	COG4264	IucA IucC family
HB368_RS10205	COG4264	IucA IucC family
HB368_RS10210	COG2814	Major facilitator Superfamily
HB368_RS10225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB368_RS10240	COG1960	acyl-CoA dehydrogenase activity
HB368_RS10245	COG1960	acyl-CoA dehydrogenase activity
HB368_RS10250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB368_RS10255	COG2207	Transcriptional regulator
HB368_RS10260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB368_RS10265	COG0776	regulation of translation
HB368_RS10290	COG0822	iron-sulfur transferase activity
HB368_RS10295	COG0316	Belongs to the HesB IscA family
HB368_RS10325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB368_RS10345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB368_RS10350	COG0702	epimerase
HB368_RS10390	COG0601	transmembrane transport
HB368_RS10395	COG0339	signal peptide processing
HB368_RS10400	COG4166	transmembrane transport
HB368_RS10445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB368_RS10450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB368_RS10480	COG0776	regulation of translation
HB368_RS10545	COG0084	hydrolase, TatD family'
HB368_RS10565	COG1663	tetraacyldisaccharide 4'-kinase activity
HB368_RS10570	COG1132	(ABC) transporter
HB368_RS10580	COG0811	peptide transport
HB368_RS10585	COG1475	DNA binding
HB368_RS10590	COG1192	Involved in chromosome partitioning
HB368_RS10600	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB368_RS10615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB368_RS10620	COG0191	fructose-bisphosphate aldolase activity
HB368_RS10640	COG0424	maF-like protein
HB368_RS10645	COG2850	peptidyl-arginine hydroxylation
HB368_RS10655	COG0640	Transcriptional regulator
HB368_RS10665	COG3619	membrane
HB368_RS10670	COG3122	Protein conserved in bacteria
HB368_RS10675	COG3328	transposase activity
HB368_RS10680	COG1132	(ABC) transporter
HB368_RS10695	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS10710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB368_RS10715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB368_RS10725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB368_RS10725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB368_RS10725	COG0506	proline dehydrogenase activity
HB368_RS10730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB368_RS10745	COG3698	Phosphodiester glycosidase
HB368_RS10755	COG2353	YceI-like domain
HB368_RS10765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB368_RS10810	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB368_RS10810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB368_RS10835	COG3539	Fimbrial protein
HB368_RS10840	COG3121	Chaperone
HB368_RS10865	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB368_RS10875	COG0583	DNA-binding transcription factor activity
HB368_RS10880	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS10900	COG1309	transcriptional regulator
HB368_RS10915	COG1522	sequence-specific DNA binding
HB368_RS10925	COG1126	abc transporter atp-binding protein
HB368_RS10930	COG0765	amino acid transport
HB368_RS10935	COG0765	amino acid transport
HB368_RS10965	COG1464	Belongs to the NlpA lipoprotein family
HB368_RS10975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB368_RS10980	COG2011	ABC-type metal ion transport system permease component
HB368_RS10985	COG0012	GTP binding
HB368_RS11005	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS11015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB368_RS11055	COG0386	Belongs to the glutathione peroxidase family
HB368_RS11065	COG0436	Aminotransferase
HB368_RS11070	COG1301	dicarboxylic acid transport
HB368_RS11105	COG3634	alkyl hydroperoxide reductase activity
HB368_RS11120	COG0583	DNA-binding transcription factor activity
HB368_RS11125	COG0798	PFAM Bile acid sodium symporter
HB368_RS11130	COG0640	Transcriptional regulator
HB368_RS11165	COG0583	DNA-binding transcription factor activity
HB368_RS11175	COG1953	Uracil, thiamine, allantoin
HB368_RS11185	COG2175	clavaminate synthase activity
HB368_RS11190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB368_RS11195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB368_RS11200	COG4521	taurine ABC transporter
HB368_RS11210	COG0477	Major facilitator Superfamily
HB368_RS11230	COG1271	oxidase subunit
HB368_RS11235	COG1294	oxidase, subunit
HB368_RS11245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS11265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB368_RS11285	COG3052	prosthetic group binding
HB368_RS11290	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB368_RS11300	COG2814	Major facilitator Superfamily
HB368_RS11315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS11320	COG1346	cytolysis
HB368_RS11330	COG0583	DNA-binding transcription factor activity
HB368_RS11335	COG0625	glutathione transferase activity
HB368_RS11340	COG0625	glutathione transferase activity
HB368_RS11345	COG0583	DNA-binding transcription factor activity
HB368_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS11360	COG1045	serine acetyltransferase
HB368_RS11365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB368_RS11370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB368_RS11375	COG1280	lysine exporter protein (LysE YggA)
HB368_RS11385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB368_RS11390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB368_RS11395	COG1126	abc transporter atp-binding protein
HB368_RS11400	COG0765	amino acid transport
HB368_RS11405	COG0765	amino acid transport
HB368_RS11425	COG2205	protein histidine kinase activity
HB368_RS11425	COG0784	Response regulator, receiver
HB368_RS11445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB368_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS11515	COG0583	DNA-binding transcription factor activity
HB368_RS11535	COG0318	PFAM AMP-dependent synthetase and ligase
HB368_RS11540	COG1309	transcriptional regulator
HB368_RS11545	COG1960	acyl-CoA dehydrogenase activity
HB368_RS11550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB368_RS11555	COG1024	Enoyl-CoA hydratase
HB368_RS11560	COG4770	biotin carboxylase activity
HB368_RS11570	COG0583	DNA-binding transcription factor activity
HB368_RS11585	COG1960	acyl-CoA dehydrogenase activity
HB368_RS11595	COG2814	Major facilitator Superfamily
HB368_RS11605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB368_RS11610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB368_RS11615	COG2814	Major facilitator Superfamily
HB368_RS11620	COG1960	acyl-CoA dehydrogenase activity
HB368_RS11625	COG1024	Enoyl-CoA hydratase
HB368_RS11630	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS11635	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB368_RS11640	COG0183	Belongs to the thiolase family
HB368_RS11650	COG2814	Major facilitator Superfamily
HB368_RS11660	COG1024	Enoyl-CoA hydratase
HB368_RS11675	COG1960	acyl-CoA dehydrogenase activity
HB368_RS11680	COG2814	Major facilitator Superfamily
HB368_RS11685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB368_RS11690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB368_RS11705	COG3842	ATPase activity
HB368_RS11710	COG1840	ABC-type Fe3 transport system, periplasmic component
HB368_RS11725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB368_RS11730	COG1414	Transcriptional regulator
HB368_RS11740	COG0583	DNA-binding transcription factor activity
HB368_RS11745	COG3038	cytochrome b561
HB368_RS11750	COG0753	catalase activity
HB368_RS11785	COG0406	alpha-ribazole phosphatase activity
HB368_RS11790	COG3328	transposase activity
HB368_RS11805	COG2050	protein possibly involved in aromatic compounds catabolism
HB368_RS11815	COG3327	negative regulation of DNA-templated transcription, initiation
HB368_RS11820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB368_RS11825	COG0183	Belongs to the thiolase family
HB368_RS11830	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB368_RS11835	COG1024	Enoyl-CoA hydratase
HB368_RS11840	COG1024	Enoyl-CoA hydratase
HB368_RS11845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB368_RS11850	COG2151	metal-sulfur cluster biosynthetic enzyme
HB368_RS11855	COG3396	Phenylacetate-CoA oxygenase
HB368_RS11860	COG3460	Phenylacetate-CoA oxygenase
HB368_RS11865	COG3396	Phenylacetate-CoA oxygenase
HB368_RS11870	COG2030	dehydratase
HB368_RS11870	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS11875	COG1760	l-serine dehydratase
HB368_RS11880	COG0531	amino acid
HB368_RS11885	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS11930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB368_RS11940	COG0789	Transcriptional regulator
HB368_RS11950	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB368_RS11965	COG2807	transmembrane transport
HB368_RS11970	COG0590	tRNA wobble adenosine to inosine editing
HB368_RS12095	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS12145	COG1116	anion transmembrane transporter activity
HB368_RS12150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB368_RS12160	COG0864	Transcriptional regulator
HB368_RS12175	COG1733	regulation of RNA biosynthetic process
HB368_RS12180	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB368_RS12185	COG0439	Biotin carboxylase
HB368_RS12200	COG1063	alcohol dehydrogenase
HB368_RS12210	COG1309	transcriptional regulator
HB368_RS12215	COG3328	transposase activity
HB368_RS12230	COG0038	chloride channel
HB368_RS12235	COG4770	biotin carboxylase activity
HB368_RS12255	COG1914	H( )-stimulated, divalent metal cation uptake system
HB368_RS12260	COG0583	DNA-binding transcription factor activity
HB368_RS12275	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS12300	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB368_RS12320	COG2814	Major facilitator Superfamily
HB368_RS12330	COG1560	Kdo2-lipid A biosynthetic process
HB368_RS12340	COG5006	permease, DMT superfamily
HB368_RS12345	COG1522	sequence-specific DNA binding
HB368_RS12360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB368_RS12370	COG4122	O-methyltransferase activity
HB368_RS12400	COG1538	Outer membrane efflux protein
HB368_RS12410	COG1137	ATPase activity
HB368_RS12415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB368_RS12425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB368_RS12450	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS12480	COG2814	Major facilitator Superfamily
HB368_RS12515	COG1278	Cold shock
HB368_RS12520	COG1280	lysine exporter protein (LysE YggA)
HB368_RS12560	COG1570	exodeoxyribonuclease VII activity
HB368_RS12610	COG0583	DNA-binding transcription factor activity
HB368_RS12615	COG4638	Rieske (2fe-2S)
HB368_RS12620	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB368_RS12625	COG0633	Ferredoxin
HB368_RS12625	COG0543	2 iron, 2 sulfur cluster binding
HB368_RS12630	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS12635	COG3135	benzoate transporter
HB368_RS12640	COG2814	Major facilitator Superfamily
HB368_RS12655	COG1643	Atp-dependent helicase
HB368_RS12660	COG0450	alkyl hydroperoxide reductase
HB368_RS12670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB368_RS12680	COG3634	alkyl hydroperoxide reductase activity
HB368_RS12700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB368_RS12720	COG0625	glutathione transferase activity
HB368_RS12730	COG2885	chlorophyll binding
HB368_RS12765	COG0542	response to heat
HB368_RS12780	COG3328	transposase activity
HB368_RS12790	COG1765	OsmC-like protein
HB368_RS12800	COG0667	Aldo Keto reductase
HB368_RS12815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB368_RS12825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB368_RS12840	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS12865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB368_RS12930	COG0592	DNA-directed DNA polymerase activity
HB368_RS13115	COG3755	Protein conserved in bacteria
HB368_RS13160	COG1484	DNA-dependent DNA replication
HB368_RS13255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB368_RS13295	COG0527	aspartate kinase activity
HB368_RS13305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB368_RS13315	COG3038	cytochrome b561
HB368_RS13320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB368_RS13325	COG2252	PERMEase
HB368_RS13335	COG2072	flavoprotein involved in K transport
HB368_RS13350	COG1741	Belongs to the pirin family
HB368_RS13355	COG1309	transcriptional regulator
HB368_RS13365	COG0300	oxidoreductase activity
HB368_RS13370	COG2072	flavoprotein involved in K transport
HB368_RS13375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB368_RS13435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB368_RS13450	COG2814	Major facilitator Superfamily
HB368_RS13455	COG1024	Enoyl-CoA hydratase
HB368_RS13460	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS13470	COG1960	acyl-CoA dehydrogenase activity
HB368_RS13495	COG2186	Transcriptional regulator
HB368_RS13500	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS13510	COG4948	Mandelate Racemase Muconate Lactonizing
HB368_RS13515	COG2271	Major facilitator Superfamily
HB368_RS13520	COG2721	sulfolactate sulfo-lyase activity
HB368_RS13525	COG0697	spore germination
HB368_RS13550	COG1113	amino acid transport
HB368_RS13570	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS13600	COG1113	amino acid transport
HB368_RS13630	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS13655	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB368_RS13655	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB368_RS13680	COG0514	ATP-dependent DNA helicase (RecQ)
HB368_RS13785	COG2161	toxin-antitoxin pair type II binding
HB368_RS13795	COG3328	transposase activity
HB368_RS13805	COG0582	viral genome integration into host DNA
HB368_RS13815	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS13815	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB368_RS13825	COG2203	Gaf domain
HB368_RS13825	COG3706	GGDEF domain
HB368_RS13825	COG4251	negative regulation of phosphorylation
HB368_RS13825	COG5001	Diguanylate cyclase
HB368_RS13835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB368_RS13855	COG4172	Belongs to the ABC transporter superfamily
HB368_RS13860	COG4239	(ABC) transporter, permease
HB368_RS13865	COG4174	ABC transporter (Permease)
HB368_RS13875	COG1388	LysM domain
HB368_RS13875	COG0741	lytic transglycosylase activity
HB368_RS13880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB368_RS13920	COG0583	DNA-binding transcription factor activity
HB368_RS13925	COG1279	arginine transmembrane transporter activity
HB368_RS13945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB368_RS13950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB368_RS13955	COG0006	proline dipeptidase activity
HB368_RS13985	COG2194	sulfuric ester hydrolase activity
HB368_RS14105	COG3620	sequence-specific DNA binding
HB368_RS14160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB368_RS14180	COG3384	dioxygenase
HB368_RS14190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB368_RS14195	COG2878	Part of a membrane complex involved in electron transport
HB368_RS14200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB368_RS14225	COG0768	penicillin binding
HB368_RS14230	COG0742	ribosomal rna small subunit methyltransferase
HB368_RS14245	COG0830	nickel cation binding
HB368_RS14255	COG0804	urea catabolic process
HB368_RS14295	COG1253	flavin adenine dinucleotide binding
HB368_RS14300	COG2851	Citrate transporter
HB368_RS14350	COG1773	rubredoxin
HB368_RS14355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB368_RS14365	COG0583	DNA-binding transcription factor activity
HB368_RS14395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HB368_RS14400	COG4181	ATPase activity
HB368_RS14445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB368_RS14465	COG0306	phosphate transporter
HB368_RS14500	COG2223	nitrite transmembrane transporter activity
HB368_RS14505	COG2207	Transcriptional regulator
HB368_RS14510	COG2066	Belongs to the glutaminase family
HB368_RS14515	COG0242	peptide deformylase activity
HB368_RS14520	COG0477	Major facilitator Superfamily
HB368_RS14530	COG0028	Belongs to the TPP enzyme family
HB368_RS14545	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS14550	COG2267	carboxylic ester hydrolase activity
HB368_RS14560	COG2271	Major facilitator Superfamily
HB368_RS14575	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS14595	COG1414	Transcriptional regulator
HB368_RS14610	COG1024	Enoyl-CoA hydratase
HB368_RS14620	COG1215	transferase activity, transferring glycosyl groups
HB368_RS14625	COG1649	PFAM Uncharacterised BCR, COG1649
HB368_RS14625	COG0726	polysaccharide deacetylase
HB368_RS14635	COG4681	YaeQ
HB368_RS14645	COG0523	cobalamin synthesis protein
HB368_RS14655	COG1607	acyl-coa hydrolase
HB368_RS14665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB368_RS14670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB368_RS14675	COG1309	transcriptional regulator
HB368_RS14700	COG2040	homocysteine
HB368_RS14705	COG0531	amino acid
HB368_RS14760	COG1595	DNA-templated transcription, initiation
HB368_RS14770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB368_RS14775	COG0477	Major facilitator Superfamily
HB368_RS14805	COG0405	Gamma-glutamyltransferase
HB368_RS14810	COG2814	Major facilitator Superfamily
HB368_RS14820	COG2050	protein possibly involved in aromatic compounds catabolism
HB368_RS14835	COG1090	epimerase
HB368_RS14855	COG0420	3'-5' exonuclease activity
HB368_RS14880	COG0735	belongs to the Fur family
HB368_RS14885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB368_RS14905	COG0121	glutamine amidotransferase
HB368_RS14920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB368_RS14930	COG0210	DNA helicase
HB368_RS14935	COG2885	chlorophyll binding
HB368_RS14940	COG0204	Acyl-transferase
HB368_RS14955	COG2894	cell division
HB368_RS14970	COG1280	lysine exporter protein (LysE YggA)
HB368_RS14975	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB368_RS14975	COG1674	ftsk spoiiie
HB368_RS14980	COG0492	ferredoxin-NADP+ reductase activity
HB368_RS14985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB368_RS14995	COG0456	acetyltransferase
HB368_RS15055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB368_RS15055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB368_RS15075	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS15100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB368_RS15110	COG0582	viral genome integration into host DNA
HB368_RS15170	COG1598	PFAM Uncharacterised protein family UPF0150
HB368_RS15265	COG5410	chromosome segregation
HB368_RS15285	COG2357	RelA SpoT domain protein
HB368_RS15365	COG0305	Participates in initiation and elongation during chromosome replication
HB368_RS15425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB368_RS15490	COG0564	pseudouridine synthase activity
HB368_RS15500	COG0358	DNA primase activity
HB368_RS15515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB368_RS15545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB368_RS15575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB368_RS15585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB368_RS15585	COG0352	thiamine-phosphate diphosphorylase activity
HB368_RS15585	COG0351	phosphomethylpyrimidine kinase
HB368_RS15590	COG1652	LysM domain
HB368_RS15615	COG1399	metal-binding, possibly nucleic acid-binding protein
HB368_RS15620	COG3101	peptidyl-lysine hydroxylation
HB368_RS15625	COG0009	L-threonylcarbamoyladenylate synthase
HB368_RS15630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB368_RS15635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB368_RS15650	COG4106	trans-aconitate 2-methyltransferase activity
HB368_RS15665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB368_RS15665	COG2226	methyltransferase
HB368_RS15665	COG0596	Alpha beta hydrolase
HB368_RS15670	COG1877	trehalose-phosphatase activity
HB368_RS15675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB368_RS15680	COG2223	nitrite transmembrane transporter activity
HB368_RS15700	COG1196	nuclear chromosome segregation
HB368_RS15710	COG0730	response to heat
HB368_RS15725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB368_RS15735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB368_RS15785	COG0489	protein tyrosine kinase activity
HB368_RS15795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB368_RS15795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB368_RS15825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB368_RS15830	COG2081	HI0933 family
HB368_RS15840	COG0668	transmembrane transport
HB368_RS15860	COG0583	DNA-binding transcription factor activity
HB368_RS15880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB368_RS15885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB368_RS15915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB368_RS15950	COG2205	protein histidine kinase activity
HB368_RS15955	COG0745	RESPONSE REGULATOR receiver
HB368_RS15975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB368_RS15990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB368_RS16005	COG0583	DNA-binding transcription factor activity
HB368_RS16035	COG0583	DNA-binding transcription factor activity
HB368_RS16050	COG0583	DNA-binding transcription factor activity
HB368_RS16055	COG1053	succinate dehydrogenase
HB368_RS16065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB368_RS16070	COG2814	Major facilitator Superfamily
HB368_RS16075	COG1960	acyl-CoA dehydrogenase activity
HB368_RS16080	COG0583	DNA-binding transcription factor activity
HB368_RS16085	COG1063	alcohol dehydrogenase
HB368_RS16115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB368_RS16120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB368_RS16125	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB368_RS16140	COG3667	copper resistance
HB368_RS16145	COG2132	Multicopper oxidase
HB368_RS16155	COG0561	phosphatase activity
HB368_RS16160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB368_RS16170	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB368_RS16185	COG1214	PFAM Peptidase M22, glycoprotease
HB368_RS16210	COG3328	transposase activity
HB368_RS16220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB368_RS16230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB368_RS16235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB368_RS16240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB368_RS16300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB368_RS16310	COG1846	Transcriptional regulator
HB368_RS16315	COG1764	response to oxidative stress
HB368_RS16355	COG0037	tRNA processing
HB368_RS16365	COG0248	Ppx GppA phosphatase
HB368_RS16395	COG0072	phenylalanine-tRNA ligase activity
HB368_RS16435	COG1238	metal cluster binding
HB368_RS16440	COG0625	glutathione transferase activity
HB368_RS16455	COG0318	PFAM AMP-dependent synthetase and ligase
HB368_RS16460	COG3028	Belongs to the UPF0307 family
HB368_RS16465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB368_RS16485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB368_RS16490	COG0617	tRNA 3'-terminal CCA addition
HB368_RS16495	COG1555	photosystem II stabilization
HB368_RS16500	COG3956	TIGRFAM MazG family protein
HB368_RS16510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB368_RS16530	COG0784	Response regulator, receiver
HB368_RS16530	COG5002	protein histidine kinase activity
HB368_RS16530	COG2205	protein histidine kinase activity
HB368_RS16535	COG1024	Enoyl-CoA hydratase
HB368_RS16540	COG2084	Dehydrogenase
HB368_RS16545	COG3622	Belongs to the hyi family
HB368_RS16575	COG0697	spore germination
HB368_RS16585	COG2814	Major facilitator Superfamily
HB368_RS16590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB368_RS16600	COG0583	DNA-binding transcription factor activity
HB368_RS16610	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB368_RS16620	COG0084	hydrolase, TatD family'
HB368_RS16635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB368_RS16660	COG2130	NADP-dependent
HB368_RS16665	COG1309	transcriptional regulator
HB368_RS16675	COG1902	pentaerythritol trinitrate reductase activity
HB368_RS16685	COG1979	alcohol dehydrogenase
HB368_RS16700	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB368_RS16715	COG3321	synthase
HB368_RS16715	COG0604	alcohol dehydrogenase
HB368_RS16720	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB368_RS16725	COG0583	DNA-binding transcription factor activity
HB368_RS16730	COG4221	oxidoreductase activity
HB368_RS16770	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS16795	COG0440	acetolactate synthase activity
HB368_RS16800	COG0028	Belongs to the TPP enzyme family
HB368_RS16825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB368_RS16830	COG0577	efflux transmembrane transporter activity
HB368_RS16830	COG1136	(ABC) transporter
HB368_RS16835	COG1538	Outer membrane efflux protein
HB368_RS16850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB368_RS16855	COG1162	GTPase activity
HB368_RS16865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB368_RS16905	COG1426	Protein conserved in bacteria
HB368_RS16940	COG0793	Belongs to the peptidase S41A family
HB368_RS16955	COG2267	carboxylic ester hydrolase activity
HB368_RS16965	COG1012	belongs to the aldehyde dehydrogenase family
HB368_RS16970	COG3265	gluconokinase activity
HB368_RS16980	COG0800	Aldolase
HB368_RS16990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB368_RS16995	COG0857	belongs to the CobB CobQ family
HB368_RS16995	COG0280	phosphate acetyltransferase
HB368_RS17000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB368_RS17000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB368_RS17020	COG0740	serine-type endopeptidase activity
HB368_RS17030	COG4774	siderophore transport
HB368_RS17040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB368_RS17050	COG2813	Specifically methylates the guanine in position
HB368_RS17050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB368_RS17155	COG0788	formyltetrahydrofolate deformylase activity
HB368_RS17180	COG4651	solute:proton antiporter activity
HB368_RS17180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB368_RS17205	COG0724	RNA recognition motif
HB368_RS17210	COG0210	DNA helicase
HB368_RS17235	COG1733	regulation of RNA biosynthetic process
HB368_RS17245	COG2900	Belongs to the SlyX family
HB368_RS17255	COG1280	lysine exporter protein (LysE YggA)
HB368_RS17260	COG1560	Kdo2-lipid A biosynthetic process
HB368_RS17270	COG1301	dicarboxylic acid transport
HB368_RS17325	COG0473	3-isopropylmalate dehydrogenase activity
HB368_RS17390	COG0583	DNA-binding transcription factor activity
HB368_RS17400	COG0625	glutathione transferase activity
HB368_RS17405	COG2378	regulation of single-species biofilm formation
HB368_RS17410	COG0546	phosphoglycolate phosphatase activity
HB368_RS17425	COG1530	ribonuclease E activity
HB368_RS17430	COG0318	PFAM AMP-dependent synthetase and ligase
HB368_RS17445	COG0583	DNA-binding transcription factor activity
HB368_RS17450	COG4221	oxidoreductase activity
HB368_RS17455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB368_RS17465	COG0534	Mate efflux family protein
HB368_RS17480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB368_RS17520	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB368_RS17525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB368_RS17540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB368_RS17550	COG0644	oxidoreductase
HB368_RS17550	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB368_RS17560	COG0425	Belongs to the sulfur carrier protein TusA family
HB368_RS17565	COG4535	Mg2 and Co2 transporter CorC
HB368_RS17575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB368_RS17595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB368_RS17600	COG0475	glutathione-regulated potassium exporter activity
HB368_RS17600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB368_RS17615	COG0484	heat shock protein binding
HB368_RS17620	COG0789	Transcriptional regulator
HB368_RS17625	COG0598	Magnesium transport protein CorA
HB368_RS17645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB368_RS17650	COG1074	ATP-dependent DNA helicase activity
HB368_RS17655	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB368_RS17675	COG2226	methyltransferase
HB368_RS17690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB368_RS17695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB368_RS17710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB368_RS17710	COG2111	Na H antiporter
HB368_RS17715	COG1006	Multisubunit Na H antiporter MnhC subunit
HB368_RS17720	COG0651	ATP synthesis coupled electron transport
HB368_RS17730	COG2212	antiporter activity
HB368_RS17750	COG0195	Participates in both transcription termination and antitermination
HB368_RS17800	COG0237	dephospho-CoA kinase activity
HB368_RS17810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB368_RS17825	COG0497	DNA recombination
HB368_RS17835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB368_RS17865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB368_RS17865	COG2169	Transcriptional regulator
HB368_RS17870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB368_RS17930	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB368_RS17945	COG0326	Molecular chaperone. Has ATPase activity
HB368_RS17960	COG2056	Na+-H+ antiporter family
HB368_RS17965	COG0596	Alpha beta hydrolase
HB368_RS17980	COG3328	transposase activity
HB368_RS18065	COG0546	phosphoglycolate phosphatase activity
HB368_RS18070	COG1716	ATPase activity
HB368_RS18115	COG0181	hydroxymethylbilane synthase activity
HB368_RS18125	COG3275	phosphorelay sensor kinase activity
HB368_RS18145	COG1538	Outer membrane efflux protein
HB368_RS18150	COG0697	spore germination
HB368_RS18175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB368_RS18180	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB368_RS18185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB368_RS18190	COG0772	Belongs to the SEDS family
HB368_RS18215	COG4974	Belongs to the 'phage' integrase family
HB368_RS18220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB368_RS18230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB368_RS18240	COG2197	response regulator
HB368_RS18255	COG0793	Belongs to the peptidase S41A family
HB368_RS18260	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB368_RS18265	COG0795	lipopolysaccharide-transporting ATPase activity
HB368_RS18305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB368_RS18305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB368_RS18315	COG0004	ammonium transporteR
HB368_RS18320	COG0347	Belongs to the P(II) protein family
HB368_RS18330	COG0606	chelatase, subunit chli
HB368_RS18355	COG1061	Type III restriction enzyme res subunit
HB368_RS18370	COG0659	secondary active sulfate transmembrane transporter activity
HB368_RS18375	COG0589	response to stress
HB368_RS18415	COG0606	chelatase, subunit chli
HB368_RS18420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB368_RS18425	COG0235	Class ii aldolase
HB368_RS18430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB368_RS18455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB368_RS18470	COG0318	PFAM AMP-dependent synthetase and ligase
HB368_RS18480	COG0477	Major facilitator Superfamily
HB368_RS18485	COG2860	membrane
HB368_RS18490	COG3012	SEC-C Motif Domain Protein
HB368_RS18495	COG1253	flavin adenine dinucleotide binding
HB368_RS18505	COG2814	Major facilitator Superfamily
HB368_RS18515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB368_RS18550	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB368_RS18560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB368_RS18595	COG1309	transcriptional regulator
HB368_RS18630	COG0758	DNA mediated transformation
HB368_RS18640	COG0697	spore germination
HB368_RS18645	COG1309	transcriptional regulator
HB368_RS18660	COG0386	Belongs to the glutathione peroxidase family
HB368_RS18730	COG1121	(ABC) transporter
HB368_RS18735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB368_RS18740	COG1280	lysine exporter protein (LysE YggA)
HB368_RS18745	COG2837	iron assimilation
HB368_RS18755	COG0281	malic enzyme
HB368_RS18800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB368_RS18800	COG0519	Catalyzes the synthesis of GMP from XMP
HB368_RS18805	COG4399	Belongs to the UPF0754 family
HB368_RS18810	COG2259	Doxx family
HB368_RS18815	COG0586	Pfam SNARE associated Golgi protein
HB368_RS18830	COG1192	Involved in chromosome partitioning
HB368_RS18840	COG0271	Belongs to the BolA IbaG family
HB368_RS18860	COG1024	Enoyl-CoA hydratase
HB368_RS18865	COG1024	Enoyl-CoA hydratase
HB368_RS18870	COG1960	acyl-CoA dehydrogenase activity
HB368_RS18875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB368_RS18895	COG1113	amino acid transport
HB368_RS18900	COG1113	amino acid transport
HB368_RS18905	COG0251	oxidation-reduction process
HB368_RS18945	COG0564	pseudouridine synthase activity
HB368_RS18980	COG1051	belongs to the nudix hydrolase family
HB368_RS19000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB368_RS19015	COG1802	Transcriptional regulator
HB368_RS19025	COG1448	Aminotransferase
HB368_RS19030	COG0277	FAD linked oxidase domain protein
HB368_RS19040	COG2186	Transcriptional regulator
HB368_RS19050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB368_RS19055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB368_RS19070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB368_RS19075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB368_RS19080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB368_RS19135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB368_RS19140	COG1596	polysaccharide export
HB368_RS19165	COG0728	peptidoglycan biosynthetic process
HB368_RS19170	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB368_RS19230	COG0546	phosphoglycolate phosphatase activity
HB368_RS19235	COG1028	Short-chain dehydrogenase reductase Sdr
HB368_RS19255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB368_RS19260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB368_RS19265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB368_RS19270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB368_RS19275	COG1116	anion transmembrane transporter activity
HB368_RS19280	COG1309	transcriptional regulator
HB368_RS19285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB368_RS19295	COG0196	riboflavin kinase activity
HB368_RS19300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB368_RS19310	COG1047	Peptidyl-prolyl cis-trans
HB368_RS19350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB368_RS19405	COG2951	lytic endotransglycosylase activity
HB368_RS19410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB368_RS19425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB368_RS19435	COG3328	transposase activity
HB368_RS19445	COG0671	phosphoesterase, PA-phosphatase related
HB368_RS19450	COG0861	Integral membrane protein TerC family
HB368_RS19460	COG0754	glutathionylspermidine amidase activity
HB368_RS19470	COG0402	S-adenosylhomocysteine deaminase activity
HB368_RS19485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB368_RS19490	COG1230	cation diffusion facilitator family transporter
HB368_RS19505	COG0706	membrane insertase activity
HB368_RS19540	COG3173	Aminoglycoside phosphotransferase
HB368_RS19560	COG0482	sulfurtransferase activity
HB368_RS19685	COG1192	Involved in chromosome partitioning
HB368_RS19710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB368_RS19730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB368_RS19735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB368_RS19780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB368_RS19830	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS19855	COG1324	tolerance protein
HB368_RS19860	COG0673	inositol 2-dehydrogenase activity
HB368_RS19880	COG2826	transposase and inactivated derivatives, IS30 family
HB368_RS19920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB368_RS19970	COG1192	Involved in chromosome partitioning
HB368_RS19980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB368_RS20025	COG0739	heme binding
HB368_RS20250	COG0501	Belongs to the peptidase M48B family
HB368_RS20285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB368_RS20335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB368_RS20450	COG2832	Protein of unknown function (DUF454)
HB368_RS20510	COG3077	Addiction module antitoxin, RelB DinJ family
HB368_RS20565	COG4683	PFAM Phage derived protein Gp49-like (DUF891)