locus-tag	class	description
HB663_RS00010	COG0592	DNA-directed DNA polymerase activity
HB663_RS00020	COG0187	DNA topoisomerase II activity
HB663_RS00030	COG0586	Pfam SNARE associated Golgi protein
HB663_RS00035	COG0488	(ABC) transporter
HB663_RS00060	COG0596	Alpha beta hydrolase
HB663_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HB663_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HB663_RS00115	COG0733	neurotransmitter:sodium symporter activity
HB663_RS00150	COG0583	DNA-binding transcription factor activity
HB663_RS00155	COG2233	PERMEase
HB663_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS00205	COG2814	Major facilitator Superfamily
HB663_RS00210	COG0656	L-ascorbic acid biosynthetic process
HB663_RS00215	COG0583	DNA-binding transcription factor activity
HB663_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB663_RS00235	COG1064	alcohol dehydrogenase
HB663_RS00240	COG2818	Glycosylase
HB663_RS00255	COG1194	a g-specific adenine glycosylase
HB663_RS00275	COG2983	Belongs to the UPF0260 family
HB663_RS00280	COG2133	pyrroloquinoline quinone binding
HB663_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HB663_RS00290	COG2116	formate transmembrane transporter activity
HB663_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB663_RS00315	COG1335	isochorismatase
HB663_RS00320	COG0385	Bile acid
HB663_RS00325	COG0534	Mate efflux family protein
HB663_RS00330	COG1683	Conserved Protein
HB663_RS00350	COG0625	glutathione transferase activity
HB663_RS00360	COG1113	amino acid transport
HB663_RS00370	COG0523	cobalamin synthesis protein
HB663_RS00380	COG2188	Transcriptional regulator
HB663_RS00410	COG0010	Belongs to the arginase family
HB663_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB663_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HB663_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HB663_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HB663_RS00535	COG0436	Aminotransferase
HB663_RS00540	COG2733	membrane
HB663_RS00555	COG2918	glutathione biosynthetic process
HB663_RS00625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB663_RS00640	COG3501	Rhs element vgr protein
HB663_RS00700	COG3150	esterase
HB663_RS00710	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS00715	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HB663_RS00725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB663_RS00740	COG2233	PERMEase
HB663_RS00745	COG2351	hydroxyisourate hydrolase activity
HB663_RS00780	COG3706	GGDEF domain
HB663_RS00795	COG1393	Belongs to the ArsC family
HB663_RS00800	COG0708	Exodeoxyribonuclease III
HB663_RS00825	COG0189	ligase activity
HB663_RS00845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HB663_RS00855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HB663_RS00870	COG4942	peptidase
HB663_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB663_RS00890	COG2119	membrane
HB663_RS00895	COG4774	siderophore transport
HB663_RS00900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB663_RS00900	COG0426	domain, Protein
HB663_RS00925	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HB663_RS00945	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS00950	COG1519	Transferase
HB663_RS00955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB663_RS00960	COG0668	transmembrane transport
HB663_RS00970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB663_RS00975	COG1335	isochorismatase
HB663_RS00980	COG1522	sequence-specific DNA binding
HB663_RS01005	COG0784	Response regulator, receiver
HB663_RS01005	COG2198	Histidine kinase
HB663_RS01005	COG2205	protein histidine kinase activity
HB663_RS01010	COG3162	membrane
HB663_RS01015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB663_RS01025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB663_RS01035	COG3706	GGDEF domain
HB663_RS01040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HB663_RS01045	COG1309	transcriptional regulator
HB663_RS01065	COG0351	phosphomethylpyrimidine kinase
HB663_RS01065	COG0352	thiamine-phosphate diphosphorylase activity
HB663_RS01065	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB663_RS01075	COG2814	Major facilitator Superfamily
HB663_RS01090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB663_RS01100	COG1113	amino acid transport
HB663_RS01110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB663_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS01125	COG1335	isochorismatase
HB663_RS01155	COG2814	Major facilitator Superfamily
HB663_RS01160	COG0583	DNA-binding transcription factor activity
HB663_RS01210	COG0667	Aldo Keto reductase
HB663_RS01230	COG1129	ABC transporter
HB663_RS01240	COG2207	Transcriptional regulator
HB663_RS01295	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HB663_RS01310	COG2329	Antibiotic biosynthesis monooxygenase
HB663_RS01325	COG1132	(ABC) transporter
HB663_RS01345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HB663_RS01375	COG0427	acetyl-CoA hydrolase
HB663_RS01390	COG0745	RESPONSE REGULATOR receiver
HB663_RS01400	COG0659	secondary active sulfate transmembrane transporter activity
HB663_RS01405	COG4221	oxidoreductase activity
HB663_RS01415	COG0488	(ABC) transporter
HB663_RS01480	COG0833	amino acid
HB663_RS01525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HB663_RS01530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HB663_RS01545	COG2226	methyltransferase
HB663_RS01595	COG0067	glutamate synthase
HB663_RS01595	COG0070	glutamate synthase
HB663_RS01595	COG0069	glutamate synthase activity
HB663_RS01600	COG0493	'glutamate synthase
HB663_RS01610	COG1704	LemA family
HB663_RS01615	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HB663_RS01635	COG3307	-O-antigen
HB663_RS01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB663_RS01670	COG0194	GDP metabolic process
HB663_RS01720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HB663_RS01740	COG5380	lipid catabolic process
HB663_RS01745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HB663_RS01770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HB663_RS01775	COG0277	FAD linked oxidase domain protein
HB663_RS01785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HB663_RS01790	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB663_RS01805	COG1289	transmembrane transporter activity
HB663_RS01815	COG0628	permease
HB663_RS01820	COG1192	Involved in chromosome partitioning
HB663_RS01850	COG0833	amino acid
HB663_RS01855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB663_RS01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB663_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS01910	COG0583	DNA-binding transcription factor activity
HB663_RS01965	COG0517	IMP dehydrogenase activity
HB663_RS01970	COG1983	PspC domain protein
HB663_RS01980	COG1960	acyl-CoA dehydrogenase activity
HB663_RS01995	COG0408	coproporphyrinogen oxidase activity
HB663_RS02015	COG0513	Belongs to the DEAD box helicase family
HB663_RS02025	COG1127	ABC transporter
HB663_RS02030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HB663_RS02040	COG2854	intermembrane phospholipid transfer
HB663_RS02050	COG0598	Magnesium transport protein CorA
HB663_RS02060	COG0494	nUDIX hydrolase
HB663_RS02065	COG1040	competence protein
HB663_RS02070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HB663_RS02090	COG1946	Acyl-CoA thioesterase
HB663_RS02095	COG1301	dicarboxylic acid transport
HB663_RS02110	COG1959	2 iron, 2 sulfur cluster binding
HB663_RS02115	COG1017	nitric oxide dioxygenase activity
HB663_RS02115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB663_RS02120	COG0433	COG0433 Predicted ATPase
HB663_RS02125	COG0626	cystathionine gamma-synthase activity
HB663_RS02280	COG1960	acyl-CoA dehydrogenase activity
HB663_RS02285	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HB663_RS02315	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HB663_RS02320	COG0339	signal peptide processing
HB663_RS02325	COG0557	exoribonuclease II activity
HB663_RS02370	COG0179	Fumarylacetoacetate (FAA) hydrolase
HB663_RS02375	COG2169	Transcriptional regulator
HB663_RS02385	COG1295	ribonuclease BN
HB663_RS02420	COG1702	phosphate starvation-inducible protein PhoH
HB663_RS02430	COG0739	heme binding
HB663_RS02430	COG0741	lytic transglycosylase activity
HB663_RS02430	COG1196	nuclear chromosome segregation
HB663_RS02450	COG3328	transposase activity
HB663_RS02465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HB663_RS02470	COG1183	phosphatidylcholine synthase activity
HB663_RS02520	COG1960	acyl-CoA dehydrogenase activity
HB663_RS02540	COG2969	positive regulation of protein catabolic process
HB663_RS02550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HB663_RS02560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HB663_RS02565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HB663_RS02570	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HB663_RS02590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HB663_RS02600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB663_RS02605	COG1408	metallophosphoesterase
HB663_RS02615	COG2199	diguanylate cyclase activity
HB663_RS02680	COG1607	acyl-coa hydrolase
HB663_RS02700	COG3328	transposase activity
HB663_RS02735	COG2205	protein histidine kinase activity
HB663_RS02750	COG2132	Multicopper oxidase
HB663_RS02775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB663_RS02810	COG3328	transposase activity
HB663_RS02830	COG0582	viral genome integration into host DNA
HB663_RS02855	COG2350	Protein conserved in bacteria
HB663_RS02865	COG0613	PHP domain protein
HB663_RS02870	COG3781	membrane
HB663_RS02880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HB663_RS02885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HB663_RS02895	COG1862	Preprotein translocase
HB663_RS02930	COG2205	protein histidine kinase activity
HB663_RS02935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HB663_RS02955	COG0726	polysaccharide deacetylase
HB663_RS02960	COG0463	Glycosyl transferase, family 2
HB663_RS02965	COG0438	transferase activity, transferring glycosyl groups
HB663_RS02980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB663_RS03030	COG1960	acyl-CoA dehydrogenase activity
HB663_RS03035	COG1960	acyl-CoA dehydrogenase activity
HB663_RS03045	COG2205	protein histidine kinase activity
HB663_RS03050	COG0745	RESPONSE REGULATOR receiver
HB663_RS03055	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HB663_RS03070	COG0584	glycerophosphoryl diester phosphodiesterase
HB663_RS03075	COG2096	Adenosyltransferase
HB663_RS03080	COG4206	TonB-dependent receptor
HB663_RS03125	COG0285	dihydrofolate synthase activity
HB663_RS03145	COG0450	alkyl hydroperoxide reductase
HB663_RS03160	COG0477	Major facilitator Superfamily
HB663_RS03165	COG1272	protein, Hemolysin III
HB663_RS03205	COG0183	Belongs to the thiolase family
HB663_RS03210	COG2207	Transcriptional regulator
HB663_RS03230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB663_RS03250	COG0183	Belongs to the thiolase family
HB663_RS03260	COG2885	chlorophyll binding
HB663_RS03260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HB663_RS03270	COG1690	Belongs to the RtcB family
HB663_RS03275	COG0833	amino acid
HB663_RS03285	COG2233	PERMEase
HB663_RS03315	COG2094	Belongs to the DNA glycosylase MPG family
HB663_RS03320	COG4772	TonB-dependent receptor
HB663_RS03325	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS03330	COG0679	Auxin Efflux Carrier
HB663_RS03340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB663_RS03345	COG0354	folic acid binding
HB663_RS03355	COG3189	MarR family transcriptional regulator
HB663_RS03360	COG2824	Alkylphosphonate utilization operon protein PhnA
HB663_RS03365	COG3422	double-strand break repair
HB663_RS03405	COG0840	transmembrane signaling receptor activity
HB663_RS03425	COG5510	response to toxic substance
HB663_RS03435	COG2832	Protein of unknown function (DUF454)
HB663_RS03440	COG1376	ErfK ybiS ycfS ynhG family protein
HB663_RS03480	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HB663_RS03490	COG1289	transmembrane transporter activity
HB663_RS03495	COG2814	Major facilitator Superfamily
HB663_RS03515	COG1115	amino acid carrier protein
HB663_RS03520	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB663_RS03525	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB663_RS03530	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HB663_RS03535	COG3590	peptidase
HB663_RS03560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB663_RS03570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HB663_RS03575	COG1077	Cell shape determining protein MreB Mrl
HB663_RS03580	COG1792	Involved in formation and maintenance of cell shape
HB663_RS03585	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HB663_RS03590	COG0424	maF-like protein
HB663_RS03595	COG1530	ribonuclease E activity
HB663_RS03605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB663_RS03615	COG0560	Phosphoserine phosphatase
HB663_RS03625	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB663_RS03650	COG2207	Transcriptional regulator
HB663_RS03690	COG1113	amino acid transport
HB663_RS03695	COG2828	Protein conserved in bacteria
HB663_RS03700	COG0142	geranyltranstransferase activity
HB663_RS03705	COG2315	Protein conserved in bacteria
HB663_RS03720	COG1752	Esterase of the alpha-beta hydrolase superfamily
HB663_RS03740	COG2194	sulfuric ester hydrolase activity
HB663_RS03745	COG0745	RESPONSE REGULATOR receiver
HB663_RS03750	COG0642	Histidine kinase
HB663_RS03760	COG0004	ammonium transporteR
HB663_RS03765	COG0583	DNA-binding transcription factor activity
HB663_RS03780	COG3328	transposase activity
HB663_RS03785	COG2226	methyltransferase
HB663_RS03790	COG0525	valine-tRNA ligase activity
HB663_RS03800	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS03810	COG0393	Putative heavy-metal-binding
HB663_RS03815	COG0393	Putative heavy-metal-binding
HB663_RS03820	COG1538	Outer membrane efflux protein
HB663_RS03830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS03835	COG0671	phosphoesterase, PA-phosphatase related
HB663_RS03865	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HB663_RS03880	COG1648	precorrin-2 dehydrogenase activity
HB663_RS03880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HB663_RS03885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HB663_RS03900	COG0531	amino acid
HB663_RS03915	COG0321	lipoyl(octanoyl) transferase activity
HB663_RS03920	COG2921	Belongs to the UPF0250 family
HB663_RS03955	COG2009	succinate dehydrogenase
HB663_RS03960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HB663_RS03965	COG1053	succinate dehydrogenase
HB663_RS03970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HB663_RS03995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB663_RS04015	COG2354	Protein conserved in bacteria
HB663_RS04020	COG2321	neutral zinc metallopeptidase
HB663_RS04050	COG2843	Capsule synthesis protein
HB663_RS04065	COG0589	response to stress
HB663_RS04075	COG0251	oxidation-reduction process
HB663_RS04080	COG1309	transcriptional regulator
HB663_RS04095	COG0505	Belongs to the CarA family
HB663_RS04120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB663_RS04125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HB663_RS04175	COG0477	Major facilitator Superfamily
HB663_RS04180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HB663_RS04195	COG1597	lipid kinase activity
HB663_RS04200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB663_RS04225	COG0584	glycerophosphoryl diester phosphodiesterase
HB663_RS04245	COG0741	lytic transglycosylase activity
HB663_RS04265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HB663_RS04280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB663_RS04295	COG0778	Nitroreductase
HB663_RS04310	COG1929	Belongs to the glycerate kinase type-1 family
HB663_RS04315	COG0243	molybdopterin cofactor binding
HB663_RS04320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HB663_RS04325	COG3339	Conserved Protein
HB663_RS04335	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HB663_RS04350	COG1115	amino acid carrier protein
HB663_RS04355	COG1113	amino acid transport
HB663_RS04365	COG0019	diaminopimelate decarboxylase activity
HB663_RS04375	COG2267	carboxylic ester hydrolase activity
HB663_RS04380	COG1280	lysine exporter protein (LysE YggA)
HB663_RS04385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB663_RS04415	COG0463	Glycosyl transferase, family 2
HB663_RS04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS04470	COG4591	ABC-type transport system involved in lipoprotein release permease component
HB663_RS04475	COG1136	(ABC) transporter
HB663_RS04480	COG0658	competence protein
HB663_RS04480	COG2333	competence protein COMEC
HB663_RS04490	COG0616	signal peptide processing
HB663_RS04490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HB663_RS04495	COG0596	Alpha beta hydrolase
HB663_RS04500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HB663_RS04510	COG0628	permease
HB663_RS04545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB663_RS04565	COG0823	Involved in the tonB-independent uptake of proteins
HB663_RS04585	COG0824	Thioesterase
HB663_RS04590	COG1473	amidohydrolase
HB663_RS04610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HB663_RS04610	COG0047	phosphoribosylformylglycinamidine synthase activity
HB663_RS04615	COG2814	Major facilitator Superfamily
HB663_RS04625	COG1024	Enoyl-CoA hydratase
HB663_RS04630	COG1051	belongs to the nudix hydrolase family
HB663_RS04630	COG1056	cytidyltransferase-related domain
HB663_RS04640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HB663_RS04655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HB663_RS04670	COG4625	pathogenesis
HB663_RS04675	COG0583	DNA-binding transcription factor activity
HB663_RS04680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HB663_RS04685	COG4208	sulfate ABC transporter
HB663_RS04690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HB663_RS04700	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HB663_RS04705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HB663_RS04710	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HB663_RS04730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB663_RS04745	COG0681	Belongs to the peptidase S26 family
HB663_RS04760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HB663_RS04770	COG1381	Involved in DNA repair and RecF pathway recombination
HB663_RS04775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HB663_RS04785	COG4221	oxidoreductase activity
HB663_RS04815	COG0443	Heat shock 70 kDa protein
HB663_RS04825	COG0436	Aminotransferase
HB663_RS04845	COG0556	nucleotide-excision repair
HB663_RS04900	COG2070	2-Nitropropane dioxygenase
HB663_RS04930	COG1215	transferase activity, transferring glycosyl groups
HB663_RS04945	COG0415	Belongs to the DNA photolyase family
HB663_RS04955	COG1252	NADH dehydrogenase
HB663_RS04960	COG1686	Belongs to the peptidase S11 family
HB663_RS04975	COG1187	pseudouridine synthase activity
HB663_RS05000	COG0477	Major facilitator Superfamily
HB663_RS05005	COG0583	DNA-binding transcription factor activity
HB663_RS05020	COG0612	Peptidase, M16
HB663_RS05045	COG0352	thiamine-phosphate diphosphorylase activity
HB663_RS05080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB663_RS05095	COG1309	transcriptional regulator
HB663_RS05105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HB663_RS05110	COG0076	glutamate decarboxylase activity
HB663_RS05120	COG1522	sequence-specific DNA binding
HB663_RS05125	COG3961	Belongs to the TPP enzyme family
HB663_RS05130	COG1113	amino acid transport
HB663_RS05135	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HB663_RS05140	COG0573	inorganic phosphate transmembrane transporter activity
HB663_RS05150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HB663_RS05155	COG0616	signal peptide processing
HB663_RS05190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HB663_RS05195	COG1686	Belongs to the peptidase S11 family
HB663_RS05220	COG0583	DNA-binding transcription factor activity
HB663_RS05225	COG1067	ATP-dependent peptidase activity
HB663_RS05250	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HB663_RS05270	COG1966	Carbon starvation protein
HB663_RS05275	COG2879	small protein
HB663_RS05290	COG1741	Belongs to the pirin family
HB663_RS05300	COG2964	Protein conserved in bacteria
HB663_RS05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB663_RS05325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HB663_RS05330	COG4605	iron ion homeostasis
HB663_RS05335	COG4604	ABC transporter, ATP-binding protein
HB663_RS05340	COG4607	ABC-type enterochelin transport system periplasmic component
HB663_RS05345	COG4774	siderophore transport
HB663_RS05355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HB663_RS05360	COG1021	2,3-dihydroxybenzoate-AMP ligase
HB663_RS05365	COG1535	isochorismatase
HB663_RS05365	COG3433	isochorismatase activity
HB663_RS05380	COG1132	(ABC) transporter
HB663_RS05385	COG5265	(ABC) transporter
HB663_RS05390	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HB663_RS05400	COG1169	isochorismate synthase
HB663_RS05415	COG3739	integral membrane protein
HB663_RS05445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HB663_RS05480	COG0512	Glutamine amidotransferase of anthranilate synthase
HB663_RS05490	COG3104	oligopeptide transport
HB663_RS05495	COG0174	glutamine synthetase
HB663_RS05505	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HB663_RS05540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HB663_RS05545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HB663_RS05550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HB663_RS05570	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HB663_RS05575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HB663_RS05580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HB663_RS05595	COG1960	acyl-CoA dehydrogenase activity
HB663_RS05600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB663_RS05605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB663_RS05615	COG2223	nitrite transmembrane transporter activity
HB663_RS05625	COG0024	Methionine aminopeptidase
HB663_RS05630	COG0052	Belongs to the universal ribosomal protein uS2 family
HB663_RS05645	COG2207	Transcriptional regulator
HB663_RS05670	COG2951	lytic endotransglycosylase activity
HB663_RS05675	COG0772	Belongs to the SEDS family
HB663_RS05690	COG0842	Transport permease protein
HB663_RS05695	COG1131	(ABC) transporter
HB663_RS05700	COG0582	viral genome integration into host DNA
HB663_RS05725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB663_RS05770	COG1484	DNA-dependent DNA replication
HB663_RS05990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS06005	COG4215	(ABC) transporter
HB663_RS06010	COG4160	amino acid transport
HB663_RS06015	COG4598	ABC transporter
HB663_RS06025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB663_RS06035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB663_RS06040	COG0384	phenazine biosynthesis protein PhzF
HB663_RS06050	COG1720	tRNA m6t6A37 methyltransferase activity
HB663_RS06070	COG0745	RESPONSE REGULATOR receiver
HB663_RS06075	COG0642	Histidine kinase
HB663_RS06085	COG0494	nUDIX hydrolase
HB663_RS06095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HB663_RS06100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HB663_RS06105	COG3139	Protein of unknown function (DUF1315)
HB663_RS06110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HB663_RS06115	COG1301	dicarboxylic acid transport
HB663_RS06120	COG1960	acyl-CoA dehydrogenase activity
HB663_RS06135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HB663_RS06145	COG2195	Cleaves the N-terminal amino acid of tripeptides
HB663_RS06170	COG1234	tRNA 3'-trailer cleavage
HB663_RS06175	COG4650	regulator
HB663_RS06205	COG2363	Small membrane protein
HB663_RS06225	COG0513	Belongs to the DEAD box helicase family
HB663_RS06235	COG0778	Nitroreductase
HB663_RS06265	COG1286	toxin biosynthetic process
HB663_RS06290	COG4783	chaperone-mediated protein folding
HB663_RS06295	COG1610	YqeY-like protein
HB663_RS06395	COG3111	PFAM Bacterial OB fold (BOF) protein
HB663_RS06420	COG3243	poly(R)-hydroxyalkanoic acid synthase
HB663_RS06425	COG0786	glutamate:sodium symporter activity
HB663_RS06435	COG2186	Transcriptional regulator
HB663_RS06455	COG2995	paraquat-inducible protein a
HB663_RS06460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HB663_RS06460	COG3008	intermembrane lipid transfer
HB663_RS06470	COG2351	hydroxyisourate hydrolase activity
HB663_RS06510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB663_RS06520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HB663_RS06525	COG0642	Histidine kinase
HB663_RS06530	COG0745	RESPONSE REGULATOR receiver
HB663_RS06550	COG1794	racemase activity, acting on amino acids and derivatives
HB663_RS06580	COG1301	dicarboxylic acid transport
HB663_RS06590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB663_RS06595	COG2011	ABC-type metal ion transport system permease component
HB663_RS06600	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB663_RS06605	COG1464	Belongs to the NlpA lipoprotein family
HB663_RS06610	COG0151	Belongs to the GarS family
HB663_RS06615	COG0138	bifunctional purine biosynthesis protein purh
HB663_RS06620	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HB663_RS06650	COG2308	Evidence 4 Homologs of previously reported genes of
HB663_RS06660	COG1305	Transglutaminase-like
HB663_RS06670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HB663_RS06675	COG0305	Participates in initiation and elongation during chromosome replication
HB663_RS06700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HB663_RS06710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HB663_RS06715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HB663_RS06740	COG0726	polysaccharide deacetylase
HB663_RS06740	COG1649	PFAM Uncharacterised BCR, COG1649
HB663_RS06745	COG1215	transferase activity, transferring glycosyl groups
HB663_RS06750	COG3658	cytochrome
HB663_RS06760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB663_RS06775	COG0583	DNA-binding transcription factor activity
HB663_RS06805	COG1960	acyl-CoA dehydrogenase activity
HB663_RS06810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB663_RS06815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB663_RS06840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HB663_RS06845	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HB663_RS06850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HB663_RS06855	COG2205	protein histidine kinase activity
HB663_RS06860	COG0745	RESPONSE REGULATOR receiver
HB663_RS06865	COG0174	glutamine synthetase
HB663_RS06885	COG0729	surface antigen
HB663_RS06915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB663_RS06920	COG2814	Major facilitator Superfamily
HB663_RS06935	COG0583	DNA-binding transcription factor activity
HB663_RS06950	COG1187	pseudouridine synthase activity
HB663_RS06970	COG0802	atpase or kinase
HB663_RS06975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HB663_RS06985	COG1923	regulation of RNA biosynthetic process
HB663_RS06990	COG0697	spore germination
HB663_RS07005	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB663_RS07015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB663_RS07020	COG0519	Catalyzes the synthesis of GMP from XMP
HB663_RS07020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB663_RS07025	COG4302	ethanolamine ammonia-lyase activity
HB663_RS07030	COG4303	Ethanolamine ammonia lyase large subunit
HB663_RS07035	COG0531	amino acid
HB663_RS07055	COG1454	alcohol dehydrogenase
HB663_RS07060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB663_RS07085	COG0308	aminopeptidase N
HB663_RS07125	COG1605	Chorismate mutase
HB663_RS07140	COG1309	transcriptional regulator
HB663_RS07150	COG0668	transmembrane transport
HB663_RS07180	COG4773	Receptor
HB663_RS07200	COG0488	(ABC) transporter
HB663_RS07205	COG0589	response to stress
HB663_RS07230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HB663_RS07240	COG3135	benzoate transporter
HB663_RS07245	COG1522	sequence-specific DNA binding
HB663_RS07255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HB663_RS07260	COG0583	DNA-binding transcription factor activity
HB663_RS07270	COG0183	Belongs to the thiolase family
HB663_RS07280	COG2030	dehydratase
HB663_RS07310	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HB663_RS07320	COG0824	Thioesterase
HB663_RS07325	COG1454	alcohol dehydrogenase
HB663_RS07335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HB663_RS07365	COG0069	glutamate synthase activity
HB663_RS07480	COG3328	transposase activity
HB663_RS07520	COG5410	chromosome segregation
HB663_RS07630	COG0739	heme binding
HB663_RS07670	COG3179	chitinase
HB663_RS07680	COG1063	alcohol dehydrogenase
HB663_RS07685	COG3293	Transposase
HB663_RS07715	COG2814	Major facilitator Superfamily
HB663_RS07730	COG0511	ligase activity, forming carbon-carbon bonds
HB663_RS07750	COG1116	anion transmembrane transporter activity
HB663_RS07750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB663_RS07755	COG0745	RESPONSE REGULATOR receiver
HB663_RS07765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB663_RS07765	COG2146	nitrite reductase [NAD(P)H] activity
HB663_RS07770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB663_RS07775	COG0243	molybdopterin cofactor binding
HB663_RS07785	COG0243	molybdopterin cofactor binding
HB663_RS07790	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HB663_RS07805	COG0315	cyclic pyranopterin monophosphate synthase activity
HB663_RS07805	COG0521	Mo-molybdopterin cofactor biosynthetic process
HB663_RS07810	COG0303	'Molybdopterin
HB663_RS07820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB663_RS07825	COG0697	spore germination
HB663_RS07845	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HB663_RS07850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB663_RS07910	COG2204	response regulator
HB663_RS07915	COG3852	Histidine kinase
HB663_RS07940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HB663_RS07945	COG0575	Belongs to the CDS family
HB663_RS07960	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB663_RS07980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB663_RS07995	COG2137	regulation of response to DNA damage stimulus
HB663_RS08005	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HB663_RS08010	COG1011	Hydrolase
HB663_RS08035	COG1522	sequence-specific DNA binding
HB663_RS08045	COG1113	amino acid transport
HB663_RS08060	COG0659	secondary active sulfate transmembrane transporter activity
HB663_RS08065	COG2135	peptidase activity
HB663_RS08080	COG5001	Diguanylate cyclase
HB663_RS08080	COG3300	MHYT domain
HB663_RS08095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB663_RS08095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HB663_RS08095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HB663_RS08100	COG1105	Belongs to the carbohydrate kinase PfkB family
HB663_RS08105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB663_RS08105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HB663_RS08140	COG0024	Methionine aminopeptidase
HB663_RS08145	COG0583	DNA-binding transcription factor activity
HB663_RS08155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HB663_RS08160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HB663_RS08165	COG0516	GMP reductase activity
HB663_RS08165	COG0517	IMP dehydrogenase activity
HB663_RS08195	COG0552	protein localization to endoplasmic reticulum
HB663_RS08220	COG4890	Cyd operon protein YbgT
HB663_RS08225	COG1294	oxidase, subunit
HB663_RS08240	COG1585	Membrane protein implicated in regulation of membrane protease activity
HB663_RS08250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HB663_RS08255	COG4774	siderophore transport
HB663_RS08270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HB663_RS08275	COG0569	domain protein
HB663_RS08280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HB663_RS08310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HB663_RS08315	COG0542	response to heat
HB663_RS08340	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB663_RS08340	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS08385	COG2323	membrane
HB663_RS08390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HB663_RS08400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB663_RS08405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB663_RS08410	COG0183	Belongs to the thiolase family
HB663_RS08415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HB663_RS08420	COG0596	Alpha beta hydrolase
HB663_RS08425	COG2271	Major facilitator Superfamily
HB663_RS08430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HB663_RS08435	COG3485	protocatechuate 3,4-dioxygenase
HB663_RS08440	COG3485	protocatechuate 3,4-dioxygenase
HB663_RS08445	COG0710	3-dehydroquinate dehydratase activity
HB663_RS08450	COG3420	alginic acid biosynthetic process
HB663_RS08455	COG3659	wide pore channel activity
HB663_RS08460	COG4993	Dehydrogenase
HB663_RS08470	COG2391	methyltransferase activity
HB663_RS08485	COG1414	Transcriptional regulator
HB663_RS08490	COG0583	DNA-binding transcription factor activity
HB663_RS08495	COG1960	acyl-CoA dehydrogenase activity
HB663_RS08520	COG2814	Major facilitator Superfamily
HB663_RS08530	COG0154	amidase activity
HB663_RS08550	COG4638	Rieske (2fe-2S)
HB663_RS08560	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS08570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB663_RS08580	COG3733	amine oxidase
HB663_RS08590	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS08600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB663_RS08605	COG0183	Belongs to the thiolase family
HB663_RS08610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB663_RS08615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB663_RS08625	COG4829	muconolactone delta-isomerase
HB663_RS08630	COG4948	Mandelate Racemase Muconate Lactonizing
HB663_RS08635	COG0583	DNA-binding transcription factor activity
HB663_RS08645	COG2186	Transcriptional regulator
HB663_RS08665	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS08680	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB663_RS08720	COG1309	transcriptional regulator
HB663_RS08725	COG0583	DNA-binding transcription factor activity
HB663_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS08735	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS08740	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS08750	COG1960	acyl-CoA dehydrogenase activity
HB663_RS08760	COG0318	PFAM AMP-dependent synthetase and ligase
HB663_RS08805	COG2188	Transcriptional regulator
HB663_RS08820	COG1566	PFAM secretion protein HlyD family protein
HB663_RS08850	COG1120	ATPase activity
HB663_RS08870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB663_RS08920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HB663_RS08965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS08970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB663_RS08975	COG1538	Outer membrane efflux protein
HB663_RS08990	COG2072	flavoprotein involved in K transport
HB663_RS09060	COG3539	Fimbrial protein
HB663_RS09085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB663_RS09095	COG0753	catalase activity
HB663_RS09125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HB663_RS09190	COG1535	isochorismatase
HB663_RS09190	COG3433	isochorismatase activity
HB663_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS09200	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HB663_RS09205	COG4149	molybdate abc transporter
HB663_RS09210	COG0725	ABC transporter, periplasmic molybdate-binding protein
HB663_RS09220	COG4638	Rieske (2fe-2S)
HB663_RS09225	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB663_RS09230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB663_RS09230	COG0543	2 iron, 2 sulfur cluster binding
HB663_RS09245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB663_RS09255	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS09265	COG3328	transposase activity
HB663_RS09275	COG2207	Transcriptional regulator
HB663_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS09285	COG2610	gluconate transmembrane transporter activity
HB663_RS09295	COG0583	DNA-binding transcription factor activity
HB663_RS09310	COG2031	fatty acid transporter
HB663_RS09315	COG0183	Belongs to the thiolase family
HB663_RS09320	COG0583	DNA-binding transcription factor activity
HB663_RS09325	COG0583	DNA-binding transcription factor activity
HB663_RS09340	COG1027	Aspartate ammonia-lyase
HB663_RS09350	COG0477	Major facilitator Superfamily
HB663_RS09370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB663_RS09375	COG4521	taurine ABC transporter
HB663_RS09390	COG2188	Transcriptional regulator
HB663_RS09400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HB663_RS09405	COG1733	regulation of RNA biosynthetic process
HB663_RS09410	COG2207	Transcriptional regulator
HB663_RS09410	COG3708	Transcriptional regulator
HB663_RS09425	COG0730	response to heat
HB663_RS09435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB663_RS09435	COG3453	Protein conserved in bacteria
HB663_RS09445	COG3781	membrane
HB663_RS09450	COG1063	alcohol dehydrogenase
HB663_RS09460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HB663_RS09465	COG0508	dehydrogenase complex catalyzes the overall conversion of
HB663_RS09470	COG0022	dehydrogenase e1 component
HB663_RS09475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HB663_RS09480	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HB663_RS09495	COG3706	GGDEF domain
HB663_RS09510	COG0133	tryptophan synthase activity
HB663_RS09520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HB663_RS09555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HB663_RS09580	COG2226	methyltransferase
HB663_RS09610	COG0537	adenosine 5'-monophosphoramidase activity
HB663_RS09635	COG0842	Transport permease protein
HB663_RS09640	COG0842	Transport permease protein
HB663_RS09645	COG1131	(ABC) transporter
HB663_RS09660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HB663_RS09665	COG4773	Receptor
HB663_RS09685	COG0730	response to heat
HB663_RS09690	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HB663_RS09705	COG0406	alpha-ribazole phosphatase activity
HB663_RS09710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HB663_RS09755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB663_RS09765	COG4264	IucA IucC family
HB663_RS09770	COG4264	IucA IucC family
HB663_RS09775	COG2814	Major facilitator Superfamily
HB663_RS09790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HB663_RS09805	COG1960	acyl-CoA dehydrogenase activity
HB663_RS09810	COG1960	acyl-CoA dehydrogenase activity
HB663_RS09815	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HB663_RS09820	COG2207	Transcriptional regulator
HB663_RS09825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB663_RS09830	COG0776	regulation of translation
HB663_RS09855	COG0822	iron-sulfur transferase activity
HB663_RS09860	COG0316	Belongs to the HesB IscA family
HB663_RS09890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HB663_RS09895	COG3328	transposase activity
HB663_RS09915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HB663_RS09920	COG0702	epimerase
HB663_RS09960	COG0601	transmembrane transport
HB663_RS09965	COG0339	signal peptide processing
HB663_RS09970	COG4166	transmembrane transport
HB663_RS10015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HB663_RS10020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HB663_RS10050	COG0776	regulation of translation
HB663_RS10115	COG0084	hydrolase, TatD family'
HB663_RS10135	COG1663	tetraacyldisaccharide 4'-kinase activity
HB663_RS10140	COG1132	(ABC) transporter
HB663_RS10150	COG0811	peptide transport
HB663_RS10155	COG1475	DNA binding
HB663_RS10160	COG1192	Involved in chromosome partitioning
HB663_RS10170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB663_RS10185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HB663_RS10190	COG0191	fructose-bisphosphate aldolase activity
HB663_RS10210	COG0424	maF-like protein
HB663_RS10215	COG2850	peptidyl-arginine hydroxylation
HB663_RS10225	COG0640	Transcriptional regulator
HB663_RS10235	COG3619	membrane
HB663_RS10240	COG3122	Protein conserved in bacteria
HB663_RS10245	COG1132	(ABC) transporter
HB663_RS10265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HB663_RS10270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HB663_RS10280	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB663_RS10280	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HB663_RS10280	COG0506	proline dehydrogenase activity
HB663_RS10285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HB663_RS10300	COG3698	Phosphodiester glycosidase
HB663_RS10310	COG2353	YceI-like domain
HB663_RS10320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HB663_RS10365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HB663_RS10365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HB663_RS10390	COG3539	Fimbrial protein
HB663_RS10395	COG3121	Chaperone
HB663_RS10420	COG0697	spore germination
HB663_RS10430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HB663_RS10440	COG0583	DNA-binding transcription factor activity
HB663_RS10460	COG1309	transcriptional regulator
HB663_RS10475	COG1522	sequence-specific DNA binding
HB663_RS10485	COG1126	abc transporter atp-binding protein
HB663_RS10490	COG0765	amino acid transport
HB663_RS10495	COG0765	amino acid transport
HB663_RS10525	COG1464	Belongs to the NlpA lipoprotein family
HB663_RS10535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HB663_RS10540	COG2011	ABC-type metal ion transport system permease component
HB663_RS10545	COG0012	GTP binding
HB663_RS10570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HB663_RS10610	COG0386	Belongs to the glutathione peroxidase family
HB663_RS10620	COG0436	Aminotransferase
HB663_RS10660	COG3634	alkyl hydroperoxide reductase activity
HB663_RS10675	COG0583	DNA-binding transcription factor activity
HB663_RS10680	COG0798	PFAM Bile acid sodium symporter
HB663_RS10685	COG0640	Transcriptional regulator
HB663_RS10700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HB663_RS10710	COG0583	DNA-binding transcription factor activity
HB663_RS10720	COG1953	Uracil, thiamine, allantoin
HB663_RS10730	COG2175	clavaminate synthase activity
HB663_RS10735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB663_RS10740	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HB663_RS10745	COG4521	taurine ABC transporter
HB663_RS10755	COG0477	Major facilitator Superfamily
HB663_RS10775	COG1271	oxidase subunit
HB663_RS10780	COG1294	oxidase, subunit
HB663_RS10790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB663_RS10810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HB663_RS10830	COG3052	prosthetic group binding
HB663_RS10835	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HB663_RS10860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HB663_RS10865	COG1346	cytolysis
HB663_RS10875	COG0583	DNA-binding transcription factor activity
HB663_RS10880	COG0625	glutathione transferase activity
HB663_RS10885	COG0625	glutathione transferase activity
HB663_RS10890	COG0583	DNA-binding transcription factor activity
HB663_RS10895	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS10905	COG1045	serine acetyltransferase
HB663_RS10910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HB663_RS10915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HB663_RS10920	COG1280	lysine exporter protein (LysE YggA)
HB663_RS10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB663_RS10935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB663_RS10940	COG1126	abc transporter atp-binding protein
HB663_RS10945	COG0765	amino acid transport
HB663_RS10950	COG0765	amino acid transport
HB663_RS10970	COG2205	protein histidine kinase activity
HB663_RS10970	COG0784	Response regulator, receiver
HB663_RS10990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB663_RS11010	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS11060	COG0583	DNA-binding transcription factor activity
HB663_RS11080	COG0318	PFAM AMP-dependent synthetase and ligase
HB663_RS11085	COG1309	transcriptional regulator
HB663_RS11090	COG1960	acyl-CoA dehydrogenase activity
HB663_RS11095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HB663_RS11100	COG1024	Enoyl-CoA hydratase
HB663_RS11105	COG4770	biotin carboxylase activity
HB663_RS11115	COG0583	DNA-binding transcription factor activity
HB663_RS11130	COG1960	acyl-CoA dehydrogenase activity
HB663_RS11140	COG2814	Major facilitator Superfamily
HB663_RS11150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HB663_RS11155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HB663_RS11160	COG2814	Major facilitator Superfamily
HB663_RS11165	COG1960	acyl-CoA dehydrogenase activity
HB663_RS11170	COG1024	Enoyl-CoA hydratase
HB663_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS11180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB663_RS11185	COG0183	Belongs to the thiolase family
HB663_RS11195	COG2814	Major facilitator Superfamily
HB663_RS11205	COG1024	Enoyl-CoA hydratase
HB663_RS11220	COG1960	acyl-CoA dehydrogenase activity
HB663_RS11225	COG2814	Major facilitator Superfamily
HB663_RS11230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HB663_RS11235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HB663_RS11250	COG3842	ATPase activity
HB663_RS11255	COG1840	ABC-type Fe3 transport system, periplasmic component
HB663_RS11270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB663_RS11275	COG1414	Transcriptional regulator
HB663_RS11285	COG0583	DNA-binding transcription factor activity
HB663_RS11290	COG3038	cytochrome b561
HB663_RS11295	COG0753	catalase activity
HB663_RS11310	COG2050	protein possibly involved in aromatic compounds catabolism
HB663_RS11320	COG3327	negative regulation of DNA-templated transcription, initiation
HB663_RS11325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HB663_RS11330	COG0183	Belongs to the thiolase family
HB663_RS11335	COG1250	3-hydroxyacyl-CoA dehydrogenase
HB663_RS11340	COG1024	Enoyl-CoA hydratase
HB663_RS11345	COG1024	Enoyl-CoA hydratase
HB663_RS11350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB663_RS11355	COG2151	metal-sulfur cluster biosynthetic enzyme
HB663_RS11360	COG3396	Phenylacetate-CoA oxygenase
HB663_RS11365	COG3460	Phenylacetate-CoA oxygenase
HB663_RS11370	COG3396	Phenylacetate-CoA oxygenase
HB663_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS11375	COG2030	dehydratase
HB663_RS11380	COG1760	l-serine dehydratase
HB663_RS11385	COG0531	amino acid
HB663_RS11390	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS11435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB663_RS11445	COG0789	Transcriptional regulator
HB663_RS11460	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HB663_RS11475	COG2807	transmembrane transport
HB663_RS11480	COG0590	tRNA wobble adenosine to inosine editing
HB663_RS11520	COG1116	anion transmembrane transporter activity
HB663_RS11525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HB663_RS11535	COG0864	Transcriptional regulator
HB663_RS11550	COG1733	regulation of RNA biosynthetic process
HB663_RS11555	COG2249	NAD(P)H dehydrogenase (quinone) activity
HB663_RS11560	COG0439	Biotin carboxylase
HB663_RS11575	COG1063	alcohol dehydrogenase
HB663_RS11585	COG1309	transcriptional regulator
HB663_RS11590	COG3328	transposase activity
HB663_RS11605	COG0038	chloride channel
HB663_RS11610	COG4770	biotin carboxylase activity
HB663_RS11630	COG1914	H( )-stimulated, divalent metal cation uptake system
HB663_RS11635	COG0583	DNA-binding transcription factor activity
HB663_RS11680	COG2814	Major facilitator Superfamily
HB663_RS11690	COG1560	Kdo2-lipid A biosynthetic process
HB663_RS11700	COG5006	permease, DMT superfamily
HB663_RS11705	COG1522	sequence-specific DNA binding
HB663_RS11720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HB663_RS11730	COG4122	O-methyltransferase activity
HB663_RS11770	COG1137	ATPase activity
HB663_RS11775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HB663_RS11785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HB663_RS11835	COG2814	Major facilitator Superfamily
HB663_RS11870	COG1278	Cold shock
HB663_RS11875	COG1280	lysine exporter protein (LysE YggA)
HB663_RS11905	COG1570	exodeoxyribonuclease VII activity
HB663_RS11955	COG0583	DNA-binding transcription factor activity
HB663_RS11960	COG4638	Rieske (2fe-2S)
HB663_RS11965	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HB663_RS11970	COG0633	Ferredoxin
HB663_RS11970	COG0543	2 iron, 2 sulfur cluster binding
HB663_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS11980	COG3135	benzoate transporter
HB663_RS11985	COG2814	Major facilitator Superfamily
HB663_RS12000	COG1643	Atp-dependent helicase
HB663_RS12005	COG0450	alkyl hydroperoxide reductase
HB663_RS12015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HB663_RS12025	COG3634	alkyl hydroperoxide reductase activity
HB663_RS12045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HB663_RS12065	COG0625	glutathione transferase activity
HB663_RS12075	COG2885	chlorophyll binding
HB663_RS12110	COG0542	response to heat
HB663_RS12125	COG3328	transposase activity
HB663_RS12135	COG1765	OsmC-like protein
HB663_RS12145	COG0667	Aldo Keto reductase
HB663_RS12160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HB663_RS12170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HB663_RS12180	COG0582	viral genome integration into host DNA
HB663_RS12205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB663_RS12285	COG0592	DNA-directed DNA polymerase activity
HB663_RS12325	COG2026	Addiction module toxin, RelE StbE family
HB663_RS12475	COG3755	Protein conserved in bacteria
HB663_RS12520	COG1484	DNA-dependent DNA replication
HB663_RS12615	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB663_RS12655	COG0527	aspartate kinase activity
HB663_RS12665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HB663_RS12675	COG3038	cytochrome b561
HB663_RS12680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HB663_RS12685	COG2252	PERMEase
HB663_RS12695	COG2072	flavoprotein involved in K transport
HB663_RS12710	COG1741	Belongs to the pirin family
HB663_RS12715	COG1309	transcriptional regulator
HB663_RS12725	COG0300	oxidoreductase activity
HB663_RS12730	COG2072	flavoprotein involved in K transport
HB663_RS12735	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HB663_RS12780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB663_RS12795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HB663_RS12810	COG2814	Major facilitator Superfamily
HB663_RS12815	COG1024	Enoyl-CoA hydratase
HB663_RS12820	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS12830	COG1960	acyl-CoA dehydrogenase activity
HB663_RS12855	COG2186	Transcriptional regulator
HB663_RS12860	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS12870	COG4948	Mandelate Racemase Muconate Lactonizing
HB663_RS12875	COG2271	Major facilitator Superfamily
HB663_RS12885	COG2721	sulfolactate sulfo-lyase activity
HB663_RS12890	COG0697	spore germination
HB663_RS12920	COG1113	amino acid transport
HB663_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS12960	COG0531	amino acid
HB663_RS12970	COG1113	amino acid transport
HB663_RS13005	COG3501	Rhs element vgr protein
HB663_RS13020	COG4269	membrane
HB663_RS13040	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB663_RS13040	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB663_RS13065	COG0514	ATP-dependent DNA helicase (RecQ)
HB663_RS13185	COG2161	toxin-antitoxin pair type II binding
HB663_RS13200	COG0582	viral genome integration into host DNA
HB663_RS13210	COG0446	pyridine nucleotide-disulphide oxidoreductase
HB663_RS13210	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS13220	COG5001	Diguanylate cyclase
HB663_RS13220	COG4251	negative regulation of phosphorylation
HB663_RS13220	COG3706	GGDEF domain
HB663_RS13220	COG2203	Gaf domain
HB663_RS13230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB663_RS13250	COG4172	Belongs to the ABC transporter superfamily
HB663_RS13255	COG4239	(ABC) transporter, permease
HB663_RS13260	COG4174	ABC transporter (Permease)
HB663_RS13270	COG1388	LysM domain
HB663_RS13270	COG0741	lytic transglycosylase activity
HB663_RS13275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HB663_RS13315	COG0583	DNA-binding transcription factor activity
HB663_RS13320	COG1279	arginine transmembrane transporter activity
HB663_RS13340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB663_RS13345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB663_RS13350	COG0006	proline dipeptidase activity
HB663_RS13380	COG3328	transposase activity
HB663_RS13385	COG2194	sulfuric ester hydrolase activity
HB663_RS13480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HB663_RS13500	COG3384	dioxygenase
HB663_RS13510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HB663_RS13515	COG2878	Part of a membrane complex involved in electron transport
HB663_RS13520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HB663_RS13545	COG0768	penicillin binding
HB663_RS13550	COG0742	ribosomal rna small subunit methyltransferase
HB663_RS13565	COG0830	nickel cation binding
HB663_RS13575	COG0804	urea catabolic process
HB663_RS13615	COG1253	flavin adenine dinucleotide binding
HB663_RS13620	COG2851	Citrate transporter
HB663_RS13670	COG1773	rubredoxin
HB663_RS13675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HB663_RS13685	COG0583	DNA-binding transcription factor activity
HB663_RS13720	COG3328	transposase activity
HB663_RS13730	COG4181	ATPase activity
HB663_RS13775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HB663_RS13795	COG0306	phosphate transporter
HB663_RS13820	COG2223	nitrite transmembrane transporter activity
HB663_RS13825	COG2207	Transcriptional regulator
HB663_RS13830	COG2066	Belongs to the glutaminase family
HB663_RS13835	COG0242	peptide deformylase activity
HB663_RS13840	COG0477	Major facilitator Superfamily
HB663_RS13850	COG0028	Belongs to the TPP enzyme family
HB663_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS13870	COG2267	carboxylic ester hydrolase activity
HB663_RS13880	COG2271	Major facilitator Superfamily
HB663_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS13915	COG1414	Transcriptional regulator
HB663_RS13930	COG1024	Enoyl-CoA hydratase
HB663_RS13940	COG1215	transferase activity, transferring glycosyl groups
HB663_RS13945	COG1649	PFAM Uncharacterised BCR, COG1649
HB663_RS13945	COG0726	polysaccharide deacetylase
HB663_RS13955	COG4681	YaeQ
HB663_RS13965	COG3328	transposase activity
HB663_RS13970	COG0523	cobalamin synthesis protein
HB663_RS13980	COG1607	acyl-coa hydrolase
HB663_RS13990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB663_RS13995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HB663_RS14000	COG1309	transcriptional regulator
HB663_RS14025	COG2040	homocysteine
HB663_RS14030	COG0531	amino acid
HB663_RS14085	COG1595	DNA-templated transcription, initiation
HB663_RS14095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HB663_RS14100	COG0477	Major facilitator Superfamily
HB663_RS14120	COG0367	asparagine synthase
HB663_RS14135	COG0582	viral genome integration into host DNA
HB663_RS14150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB663_RS14180	COG3179	chitinase
HB663_RS14225	COG0739	heme binding
HB663_RS14325	COG5410	chromosome segregation
HB663_RS14415	COG4197	protein conserved in bacteria, prophage-related
HB663_RS14420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HB663_RS14485	COG0405	Gamma-glutamyltransferase
HB663_RS14490	COG2814	Major facilitator Superfamily
HB663_RS14500	COG2050	protein possibly involved in aromatic compounds catabolism
HB663_RS14515	COG1090	epimerase
HB663_RS14535	COG0420	3'-5' exonuclease activity
HB663_RS14560	COG0735	belongs to the Fur family
HB663_RS14565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HB663_RS14585	COG0121	glutamine amidotransferase
HB663_RS14600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB663_RS14610	COG0210	DNA helicase
HB663_RS14615	COG2885	chlorophyll binding
HB663_RS14620	COG0204	Acyl-transferase
HB663_RS14635	COG2894	cell division
HB663_RS14650	COG1280	lysine exporter protein (LysE YggA)
HB663_RS14655	COG1674	ftsk spoiiie
HB663_RS14655	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HB663_RS14660	COG0492	ferredoxin-NADP+ reductase activity
HB663_RS14665	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HB663_RS14675	COG0456	acetyltransferase
HB663_RS14735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB663_RS14735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HB663_RS14755	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS14775	COG0473	3-isopropylmalate dehydrogenase activity
HB663_RS14780	COG0583	DNA-binding transcription factor activity
HB663_RS14800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HB663_RS14825	COG0564	pseudouridine synthase activity
HB663_RS14835	COG0358	DNA primase activity
HB663_RS14850	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HB663_RS14880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HB663_RS14910	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HB663_RS14920	COG0351	phosphomethylpyrimidine kinase
HB663_RS14920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HB663_RS14920	COG0352	thiamine-phosphate diphosphorylase activity
HB663_RS14925	COG1652	LysM domain
HB663_RS14950	COG1399	metal-binding, possibly nucleic acid-binding protein
HB663_RS14955	COG3101	peptidyl-lysine hydroxylation
HB663_RS14960	COG0009	L-threonylcarbamoyladenylate synthase
HB663_RS14965	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HB663_RS14970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HB663_RS14985	COG4106	trans-aconitate 2-methyltransferase activity
HB663_RS15000	COG2226	methyltransferase
HB663_RS15000	COG0596	Alpha beta hydrolase
HB663_RS15000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB663_RS15005	COG1877	trehalose-phosphatase activity
HB663_RS15010	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HB663_RS15015	COG2223	nitrite transmembrane transporter activity
HB663_RS15035	COG1196	nuclear chromosome segregation
HB663_RS15045	COG0730	response to heat
HB663_RS15060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HB663_RS15070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB663_RS15120	COG0489	protein tyrosine kinase activity
HB663_RS15130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB663_RS15130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB663_RS15160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HB663_RS15165	COG2081	HI0933 family
HB663_RS15175	COG0668	transmembrane transport
HB663_RS15195	COG0583	DNA-binding transcription factor activity
HB663_RS15215	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HB663_RS15220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB663_RS15250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HB663_RS15285	COG2205	protein histidine kinase activity
HB663_RS15290	COG0745	RESPONSE REGULATOR receiver
HB663_RS15310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HB663_RS15325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HB663_RS15340	COG0583	DNA-binding transcription factor activity
HB663_RS15370	COG0583	DNA-binding transcription factor activity
HB663_RS15385	COG0583	DNA-binding transcription factor activity
HB663_RS15390	COG1053	succinate dehydrogenase
HB663_RS15400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HB663_RS15405	COG2814	Major facilitator Superfamily
HB663_RS15410	COG1960	acyl-CoA dehydrogenase activity
HB663_RS15415	COG0583	DNA-binding transcription factor activity
HB663_RS15420	COG1063	alcohol dehydrogenase
HB663_RS15450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HB663_RS15455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HB663_RS15460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB663_RS15475	COG3667	copper resistance
HB663_RS15480	COG2132	Multicopper oxidase
HB663_RS15490	COG0561	phosphatase activity
HB663_RS15495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HB663_RS15505	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB663_RS15520	COG1214	PFAM Peptidase M22, glycoprotease
HB663_RS15545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HB663_RS15555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HB663_RS15560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HB663_RS15565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HB663_RS15630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HB663_RS15640	COG1846	Transcriptional regulator
HB663_RS15645	COG1764	response to oxidative stress
HB663_RS15685	COG0037	tRNA processing
HB663_RS15695	COG0248	Ppx GppA phosphatase
HB663_RS15725	COG0072	phenylalanine-tRNA ligase activity
HB663_RS15775	COG1238	metal cluster binding
HB663_RS15780	COG0625	glutathione transferase activity
HB663_RS15795	COG0318	PFAM AMP-dependent synthetase and ligase
HB663_RS15800	COG3028	Belongs to the UPF0307 family
HB663_RS15805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HB663_RS15825	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HB663_RS15830	COG0617	tRNA 3'-terminal CCA addition
HB663_RS15835	COG1555	photosystem II stabilization
HB663_RS15840	COG3956	TIGRFAM MazG family protein
HB663_RS15850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HB663_RS15870	COG0784	Response regulator, receiver
HB663_RS15870	COG2205	protein histidine kinase activity
HB663_RS15870	COG5002	protein histidine kinase activity
HB663_RS15875	COG1024	Enoyl-CoA hydratase
HB663_RS15880	COG2084	Dehydrogenase
HB663_RS15885	COG3622	Belongs to the hyi family
HB663_RS15915	COG0697	spore germination
HB663_RS15925	COG2814	Major facilitator Superfamily
HB663_RS15930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HB663_RS15940	COG0583	DNA-binding transcription factor activity
HB663_RS15950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HB663_RS15960	COG0084	hydrolase, TatD family'
HB663_RS15975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HB663_RS16000	COG2130	NADP-dependent
HB663_RS16005	COG1309	transcriptional regulator
HB663_RS16015	COG1902	pentaerythritol trinitrate reductase activity
HB663_RS16025	COG1979	alcohol dehydrogenase
HB663_RS16040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HB663_RS16055	COG3321	synthase
HB663_RS16055	COG0604	alcohol dehydrogenase
HB663_RS16060	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HB663_RS16065	COG0583	DNA-binding transcription factor activity
HB663_RS16070	COG4221	oxidoreductase activity
HB663_RS16100	COG0440	acetolactate synthase activity
HB663_RS16105	COG0028	Belongs to the TPP enzyme family
HB663_RS16130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HB663_RS16135	COG0577	efflux transmembrane transporter activity
HB663_RS16135	COG1136	(ABC) transporter
HB663_RS16140	COG1538	Outer membrane efflux protein
HB663_RS16155	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HB663_RS16160	COG1162	GTPase activity
HB663_RS16170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HB663_RS16210	COG1426	Protein conserved in bacteria
HB663_RS16245	COG0793	Belongs to the peptidase S41A family
HB663_RS16260	COG2267	carboxylic ester hydrolase activity
HB663_RS16270	COG1012	belongs to the aldehyde dehydrogenase family
HB663_RS16275	COG3265	gluconokinase activity
HB663_RS16285	COG0800	Aldolase
HB663_RS16295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HB663_RS16300	COG0280	phosphate acetyltransferase
HB663_RS16300	COG0857	belongs to the CobB CobQ family
HB663_RS16305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HB663_RS16305	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HB663_RS16325	COG0740	serine-type endopeptidase activity
HB663_RS16335	COG4774	siderophore transport
HB663_RS16345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HB663_RS16355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HB663_RS16355	COG2813	Specifically methylates the guanine in position
HB663_RS16460	COG0788	formyltetrahydrofolate deformylase activity
HB663_RS16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB663_RS16485	COG4651	solute:proton antiporter activity
HB663_RS16510	COG0724	RNA recognition motif
HB663_RS16515	COG0210	DNA helicase
HB663_RS16540	COG1733	regulation of RNA biosynthetic process
HB663_RS16550	COG2900	Belongs to the SlyX family
HB663_RS16560	COG1280	lysine exporter protein (LysE YggA)
HB663_RS16565	COG1560	Kdo2-lipid A biosynthetic process
HB663_RS16575	COG1301	dicarboxylic acid transport
HB663_RS16630	COG0473	3-isopropylmalate dehydrogenase activity
HB663_RS16695	COG0583	DNA-binding transcription factor activity
HB663_RS16700	COG3328	transposase activity
HB663_RS16710	COG0625	glutathione transferase activity
HB663_RS16715	COG2378	regulation of single-species biofilm formation
HB663_RS16720	COG0546	phosphoglycolate phosphatase activity
HB663_RS16735	COG1530	ribonuclease E activity
HB663_RS16740	COG0318	PFAM AMP-dependent synthetase and ligase
HB663_RS16755	COG0583	DNA-binding transcription factor activity
HB663_RS16760	COG4221	oxidoreductase activity
HB663_RS16765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HB663_RS16775	COG0534	Mate efflux family protein
HB663_RS16790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HB663_RS16830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HB663_RS16835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HB663_RS16850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HB663_RS16860	COG0644	oxidoreductase
HB663_RS16860	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HB663_RS16870	COG0425	Belongs to the sulfur carrier protein TusA family
HB663_RS16875	COG4535	Mg2 and Co2 transporter CorC
HB663_RS16885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HB663_RS16905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HB663_RS16910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HB663_RS16910	COG0475	glutathione-regulated potassium exporter activity
HB663_RS16925	COG0484	heat shock protein binding
HB663_RS16930	COG0789	Transcriptional regulator
HB663_RS16935	COG0598	Magnesium transport protein CorA
HB663_RS16955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HB663_RS16960	COG1074	ATP-dependent DNA helicase activity
HB663_RS16965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HB663_RS16985	COG2226	methyltransferase
HB663_RS17000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HB663_RS17005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HB663_RS17020	COG2111	Na H antiporter
HB663_RS17020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HB663_RS17025	COG1006	Multisubunit Na H antiporter MnhC subunit
HB663_RS17030	COG0651	ATP synthesis coupled electron transport
HB663_RS17040	COG2212	antiporter activity
HB663_RS17060	COG0195	Participates in both transcription termination and antitermination
HB663_RS17110	COG0237	dephospho-CoA kinase activity
HB663_RS17120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HB663_RS17135	COG0497	DNA recombination
HB663_RS17145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HB663_RS17175	COG2169	Transcriptional regulator
HB663_RS17175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HB663_RS17180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HB663_RS17240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HB663_RS17255	COG0326	Molecular chaperone. Has ATPase activity
HB663_RS17270	COG2056	Na+-H+ antiporter family
HB663_RS17275	COG0596	Alpha beta hydrolase
HB663_RS17370	COG0546	phosphoglycolate phosphatase activity
HB663_RS17375	COG1716	ATPase activity
HB663_RS17420	COG0181	hydroxymethylbilane synthase activity
HB663_RS17430	COG3275	phosphorelay sensor kinase activity
HB663_RS17450	COG1538	Outer membrane efflux protein
HB663_RS17455	COG0697	spore germination
HB663_RS17480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HB663_RS17485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HB663_RS17490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HB663_RS17495	COG0772	Belongs to the SEDS family
HB663_RS17520	COG4974	Belongs to the 'phage' integrase family
HB663_RS17525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB663_RS17535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HB663_RS17545	COG2197	response regulator
HB663_RS17560	COG0793	Belongs to the peptidase S41A family
HB663_RS17565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HB663_RS17570	COG0795	lipopolysaccharide-transporting ATPase activity
HB663_RS17610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB663_RS17610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HB663_RS17620	COG0004	ammonium transporteR
HB663_RS17625	COG0347	Belongs to the P(II) protein family
HB663_RS17635	COG0606	chelatase, subunit chli
HB663_RS17655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HB663_RS17670	COG0318	PFAM AMP-dependent synthetase and ligase
HB663_RS17680	COG0477	Major facilitator Superfamily
HB663_RS17685	COG2860	membrane
HB663_RS17690	COG3012	SEC-C Motif Domain Protein
HB663_RS17695	COG1253	flavin adenine dinucleotide binding
HB663_RS17705	COG2814	Major facilitator Superfamily
HB663_RS17715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB663_RS17750	COG0655	NAD(P)H dehydrogenase (quinone) activity
HB663_RS17760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HB663_RS17800	COG1309	transcriptional regulator
HB663_RS17835	COG0758	DNA mediated transformation
HB663_RS17845	COG0697	spore germination
HB663_RS17850	COG1309	transcriptional regulator
HB663_RS17865	COG0386	Belongs to the glutathione peroxidase family
HB663_RS17935	COG1121	(ABC) transporter
HB663_RS17940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HB663_RS17945	COG1280	lysine exporter protein (LysE YggA)
HB663_RS17950	COG2837	iron assimilation
HB663_RS17960	COG0281	malic enzyme
HB663_RS18005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HB663_RS18005	COG0519	Catalyzes the synthesis of GMP from XMP
HB663_RS18010	COG4399	Belongs to the UPF0754 family
HB663_RS18015	COG2259	Doxx family
HB663_RS18020	COG0586	Pfam SNARE associated Golgi protein
HB663_RS18035	COG1192	Involved in chromosome partitioning
HB663_RS18045	COG0271	Belongs to the BolA IbaG family
HB663_RS18065	COG1024	Enoyl-CoA hydratase
HB663_RS18070	COG1024	Enoyl-CoA hydratase
HB663_RS18075	COG1960	acyl-CoA dehydrogenase activity
HB663_RS18080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HB663_RS18100	COG1113	amino acid transport
HB663_RS18105	COG1113	amino acid transport
HB663_RS18110	COG0251	oxidation-reduction process
HB663_RS18150	COG0564	pseudouridine synthase activity
HB663_RS18220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HB663_RS18235	COG1802	Transcriptional regulator
HB663_RS18245	COG1448	Aminotransferase
HB663_RS18250	COG0277	FAD linked oxidase domain protein
HB663_RS18260	COG2186	Transcriptional regulator
HB663_RS18270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB663_RS18275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HB663_RS18290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HB663_RS18295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HB663_RS18300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HB663_RS18345	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS18350	COG1083	cytidylyl-transferase
HB663_RS18355	COG0673	inositol 2-dehydrogenase activity
HB663_RS18360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HB663_RS18365	COG1045	serine acetyltransferase
HB663_RS18370	COG2089	acid synthase
HB663_RS18375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HB663_RS18380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HB663_RS18390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HB663_RS18395	COG1596	polysaccharide export
HB663_RS18420	COG0728	peptidoglycan biosynthetic process
HB663_RS18425	COG3023	N-Acetylmuramoyl-L-alanine amidase
HB663_RS18485	COG0546	phosphoglycolate phosphatase activity
HB663_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
HB663_RS18510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB663_RS18515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HB663_RS18520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HB663_RS18525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HB663_RS18530	COG1116	anion transmembrane transporter activity
HB663_RS18535	COG1309	transcriptional regulator
HB663_RS18540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HB663_RS18550	COG0196	riboflavin kinase activity
HB663_RS18555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HB663_RS18565	COG1047	Peptidyl-prolyl cis-trans
HB663_RS18610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HB663_RS18665	COG2951	lytic endotransglycosylase activity
HB663_RS18670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HB663_RS18685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HB663_RS18695	COG3328	transposase activity
HB663_RS18705	COG0671	phosphoesterase, PA-phosphatase related
HB663_RS18710	COG0861	Integral membrane protein TerC family
HB663_RS18720	COG0754	glutathionylspermidine amidase activity
HB663_RS18730	COG0402	S-adenosylhomocysteine deaminase activity
HB663_RS18745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HB663_RS18750	COG1230	cation diffusion facilitator family transporter
HB663_RS18765	COG3328	transposase activity
HB663_RS18775	COG0706	membrane insertase activity
HB663_RS18810	COG3173	Aminoglycoside phosphotransferase
HB663_RS18830	COG0482	sulfurtransferase activity
HB663_RS18985	COG1192	Involved in chromosome partitioning
HB663_RS19010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB663_RS19030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HB663_RS19035	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HB663_RS19080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HB663_RS19160	COG4266	Belongs to the allantoicase family
HB663_RS19175	COG2233	PERMEase
HB663_RS19180	COG2351	hydroxyisourate hydrolase activity
HB663_RS19245	COG0789	Transcriptional regulator
HB663_RS19265	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HB663_RS19270	COG0659	secondary active sulfate transmembrane transporter activity
HB663_RS19335	COG1373	ATPase (AAA superfamily
HB663_RS19375	COG1309	transcriptional regulator
HB663_RS19405	COG0633	Ferredoxin
HB663_RS19410	COG2207	Transcriptional regulator
HB663_RS19565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HB663_RS19615	COG1192	Involved in chromosome partitioning
HB663_RS19625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HB663_RS19670	COG0739	heme binding
HB663_RS19895	COG0501	Belongs to the peptidase M48B family
HB663_RS19930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HB663_RS19980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HB663_RS20070	COG2826	transposase and inactivated derivatives, IS30 family
HB663_RS20110	COG4683	PFAM Phage derived protein Gp49-like (DUF891)