locus-tag	class	description
EA665_RS00010	COG0592	DNA-directed DNA polymerase activity
EA665_RS00020	COG0187	DNA topoisomerase II activity
EA665_RS00030	COG0586	Pfam SNARE associated Golgi protein
EA665_RS00035	COG0488	(ABC) transporter
EA665_RS00060	COG0596	Alpha beta hydrolase
EA665_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EA665_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EA665_RS00115	COG0733	neurotransmitter:sodium symporter activity
EA665_RS00150	COG0583	DNA-binding transcription factor activity
EA665_RS00155	COG2233	PERMEase
EA665_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS00205	COG2814	Major facilitator Superfamily
EA665_RS00210	COG0656	L-ascorbic acid biosynthetic process
EA665_RS00215	COG0583	DNA-binding transcription factor activity
EA665_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EA665_RS00235	COG1064	alcohol dehydrogenase
EA665_RS00240	COG2818	Glycosylase
EA665_RS00255	COG1194	a g-specific adenine glycosylase
EA665_RS00275	COG2983	Belongs to the UPF0260 family
EA665_RS00280	COG2133	pyrroloquinoline quinone binding
EA665_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EA665_RS00290	COG2116	formate transmembrane transporter activity
EA665_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EA665_RS00315	COG1335	isochorismatase
EA665_RS00320	COG0385	Bile acid
EA665_RS00330	COG1683	Conserved Protein
EA665_RS00350	COG0625	glutathione transferase activity
EA665_RS00360	COG1113	amino acid transport
EA665_RS00370	COG0523	cobalamin synthesis protein
EA665_RS00380	COG2188	Transcriptional regulator
EA665_RS00400	COG1126	abc transporter atp-binding protein
EA665_RS00470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EA665_RS00515	COG2963	transposase activity
EA665_RS00545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EA665_RS00610	COG0010	Belongs to the arginase family
EA665_RS00625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EA665_RS00630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EA665_RS00640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EA665_RS00645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EA665_RS00735	COG0534	Mate efflux family protein
EA665_RS00740	COG0436	Aminotransferase
EA665_RS00745	COG2733	membrane
EA665_RS00760	COG2918	glutathione biosynthetic process
EA665_RS00775	COG3179	chitinase
EA665_RS00790	COG3150	esterase
EA665_RS00800	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EA665_RS00810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA665_RS00820	COG2233	PERMEase
EA665_RS00825	COG2351	hydroxyisourate hydrolase activity
EA665_RS00860	COG3706	GGDEF domain
EA665_RS00875	COG1393	Belongs to the ArsC family
EA665_RS00880	COG0708	Exodeoxyribonuclease III
EA665_RS00905	COG0189	ligase activity
EA665_RS00925	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EA665_RS00935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EA665_RS00950	COG4942	peptidase
EA665_RS00960	COG0508	dehydrogenase complex catalyzes the overall conversion of
EA665_RS00970	COG2119	membrane
EA665_RS00975	COG4774	siderophore transport
EA665_RS00980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS00980	COG0426	domain, Protein
EA665_RS01005	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EA665_RS01030	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS01035	COG1519	Transferase
EA665_RS01040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EA665_RS01045	COG0668	transmembrane transport
EA665_RS01055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EA665_RS01060	COG1335	isochorismatase
EA665_RS01065	COG1522	sequence-specific DNA binding
EA665_RS01090	COG2205	protein histidine kinase activity
EA665_RS01090	COG2198	Histidine kinase
EA665_RS01090	COG0784	Response regulator, receiver
EA665_RS01095	COG3162	membrane
EA665_RS01100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EA665_RS01110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EA665_RS01130	COG1309	transcriptional regulator
EA665_RS01150	COG0352	thiamine-phosphate diphosphorylase activity
EA665_RS01150	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EA665_RS01150	COG0351	phosphomethylpyrimidine kinase
EA665_RS01160	COG2814	Major facilitator Superfamily
EA665_RS01175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EA665_RS01185	COG1113	amino acid transport
EA665_RS01195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EA665_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS01210	COG1335	isochorismatase
EA665_RS01240	COG2814	Major facilitator Superfamily
EA665_RS01245	COG0583	DNA-binding transcription factor activity
EA665_RS01265	COG0667	Aldo Keto reductase
EA665_RS01300	COG1733	regulation of RNA biosynthetic process
EA665_RS01310	COG2249	NAD(P)H dehydrogenase (quinone) activity
EA665_RS01370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EA665_RS01395	COG1132	(ABC) transporter
EA665_RS01415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EA665_RS01445	COG0427	acetyl-CoA hydrolase
EA665_RS01470	COG0659	secondary active sulfate transmembrane transporter activity
EA665_RS01475	COG4221	oxidoreductase activity
EA665_RS01485	COG0488	(ABC) transporter
EA665_RS01550	COG0833	amino acid
EA665_RS01595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EA665_RS01600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EA665_RS01615	COG2226	methyltransferase
EA665_RS01665	COG0067	glutamate synthase
EA665_RS01665	COG0069	glutamate synthase activity
EA665_RS01665	COG0070	glutamate synthase
EA665_RS01670	COG0493	'glutamate synthase
EA665_RS01680	COG1704	LemA family
EA665_RS01685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EA665_RS01705	COG3307	-O-antigen
EA665_RS01725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EA665_RS01740	COG0194	GDP metabolic process
EA665_RS01790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EA665_RS01810	COG5380	lipid catabolic process
EA665_RS01815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EA665_RS01840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EA665_RS01845	COG0277	FAD linked oxidase domain protein
EA665_RS01860	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EA665_RS01865	COG2249	NAD(P)H dehydrogenase (quinone) activity
EA665_RS01880	COG1289	transmembrane transporter activity
EA665_RS01890	COG0628	permease
EA665_RS01895	COG1192	Involved in chromosome partitioning
EA665_RS01925	COG0833	amino acid
EA665_RS01935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EA665_RS01940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EA665_RS01950	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS01990	COG0583	DNA-binding transcription factor activity
EA665_RS02040	COG0517	IMP dehydrogenase activity
EA665_RS02045	COG1983	PspC domain protein
EA665_RS02055	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02070	COG0408	coproporphyrinogen oxidase activity
EA665_RS02090	COG0513	Belongs to the DEAD box helicase family
EA665_RS02100	COG1127	ABC transporter
EA665_RS02105	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EA665_RS02115	COG2854	intermembrane phospholipid transfer
EA665_RS02125	COG0598	Magnesium transport protein CorA
EA665_RS02135	COG0494	nUDIX hydrolase
EA665_RS02140	COG1040	competence protein
EA665_RS02145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EA665_RS02165	COG1946	Acyl-CoA thioesterase
EA665_RS02170	COG1301	dicarboxylic acid transport
EA665_RS02185	COG1959	2 iron, 2 sulfur cluster binding
EA665_RS02190	COG1017	nitric oxide dioxygenase activity
EA665_RS02190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EA665_RS02200	COG0433	COG0433 Predicted ATPase
EA665_RS02205	COG0626	cystathionine gamma-synthase activity
EA665_RS02360	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02365	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EA665_RS02395	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EA665_RS02400	COG0339	signal peptide processing
EA665_RS02405	COG0557	exoribonuclease II activity
EA665_RS02450	COG0179	Fumarylacetoacetate (FAA) hydrolase
EA665_RS02455	COG2169	Transcriptional regulator
EA665_RS02460	COG0697	spore germination
EA665_RS02465	COG1295	ribonuclease BN
EA665_RS02500	COG1702	phosphate starvation-inducible protein PhoH
EA665_RS02510	COG0741	lytic transglycosylase activity
EA665_RS02510	COG1196	nuclear chromosome segregation
EA665_RS02510	COG0739	heme binding
EA665_RS02540	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EA665_RS02545	COG1183	phosphatidylcholine synthase activity
EA665_RS02590	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02595	COG1309	transcriptional regulator
EA665_RS02610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EA665_RS02615	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02635	COG2969	positive regulation of protein catabolic process
EA665_RS02645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EA665_RS02655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EA665_RS02660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EA665_RS02665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EA665_RS02685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EA665_RS02695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EA665_RS02700	COG1408	metallophosphoesterase
EA665_RS02710	COG2199	diguanylate cyclase activity
EA665_RS02770	COG1607	acyl-coa hydrolase
EA665_RS02800	COG2350	Protein conserved in bacteria
EA665_RS02810	COG0613	PHP domain protein
EA665_RS02815	COG3781	membrane
EA665_RS02825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EA665_RS02830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EA665_RS02840	COG1862	Preprotein translocase
EA665_RS02870	COG2205	protein histidine kinase activity
EA665_RS02875	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EA665_RS02895	COG0726	polysaccharide deacetylase
EA665_RS02900	COG0463	Glycosyl transferase, family 2
EA665_RS02905	COG0438	transferase activity, transferring glycosyl groups
EA665_RS02970	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02975	COG1960	acyl-CoA dehydrogenase activity
EA665_RS02985	COG2205	protein histidine kinase activity
EA665_RS02990	COG0745	RESPONSE REGULATOR receiver
EA665_RS02995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EA665_RS03015	COG2096	Adenosyltransferase
EA665_RS03065	COG0285	dihydrofolate synthase activity
EA665_RS03085	COG0450	alkyl hydroperoxide reductase
EA665_RS03100	COG0477	Major facilitator Superfamily
EA665_RS03105	COG1272	protein, Hemolysin III
EA665_RS03135	COG0183	Belongs to the thiolase family
EA665_RS03140	COG2207	Transcriptional regulator
EA665_RS03160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EA665_RS03180	COG0183	Belongs to the thiolase family
EA665_RS03190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EA665_RS03190	COG2885	chlorophyll binding
EA665_RS03200	COG1690	Belongs to the RtcB family
EA665_RS03205	COG0833	amino acid
EA665_RS03215	COG2233	PERMEase
EA665_RS03220	COG1217	gtp-binding protein TYPA
EA665_RS03245	COG2094	Belongs to the DNA glycosylase MPG family
EA665_RS03250	COG4772	TonB-dependent receptor
EA665_RS03255	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS03270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EA665_RS03275	COG0354	folic acid binding
EA665_RS03285	COG3189	MarR family transcriptional regulator
EA665_RS03290	COG2824	Alkylphosphonate utilization operon protein PhnA
EA665_RS03295	COG3422	double-strand break repair
EA665_RS03335	COG0840	transmembrane signaling receptor activity
EA665_RS03355	COG5510	response to toxic substance
EA665_RS03365	COG2832	Protein of unknown function (DUF454)
EA665_RS03370	COG1376	ErfK ybiS ycfS ynhG family protein
EA665_RS03410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EA665_RS03420	COG1289	transmembrane transporter activity
EA665_RS03425	COG2814	Major facilitator Superfamily
EA665_RS03445	COG1115	amino acid carrier protein
EA665_RS03450	COG1752	Esterase of the alpha-beta hydrolase superfamily
EA665_RS03455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EA665_RS03460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EA665_RS03485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EA665_RS03495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EA665_RS03500	COG1077	Cell shape determining protein MreB Mrl
EA665_RS03505	COG1792	Involved in formation and maintenance of cell shape
EA665_RS03510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EA665_RS03515	COG0424	maF-like protein
EA665_RS03520	COG1530	ribonuclease E activity
EA665_RS03530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EA665_RS03540	COG0560	Phosphoserine phosphatase
EA665_RS03550	COG2249	NAD(P)H dehydrogenase (quinone) activity
EA665_RS03575	COG2207	Transcriptional regulator
EA665_RS03625	COG1113	amino acid transport
EA665_RS03630	COG2828	Protein conserved in bacteria
EA665_RS03635	COG0142	geranyltranstransferase activity
EA665_RS03640	COG2315	Protein conserved in bacteria
EA665_RS03655	COG1752	Esterase of the alpha-beta hydrolase superfamily
EA665_RS03670	COG2963	transposase activity
EA665_RS03680	COG4372	Transposase
EA665_RS03705	COG2963	transposase activity
EA665_RS03715	COG0745	RESPONSE REGULATOR receiver
EA665_RS03720	COG0642	Histidine kinase
EA665_RS03730	COG0004	ammonium transporteR
EA665_RS03740	COG0583	DNA-binding transcription factor activity
EA665_RS03755	COG2226	methyltransferase
EA665_RS03760	COG0525	valine-tRNA ligase activity
EA665_RS03770	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS03780	COG0393	Putative heavy-metal-binding
EA665_RS03785	COG0393	Putative heavy-metal-binding
EA665_RS03790	COG1538	Outer membrane efflux protein
EA665_RS03800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS03805	COG0671	phosphoesterase, PA-phosphatase related
EA665_RS03835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EA665_RS03850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EA665_RS03850	COG1648	precorrin-2 dehydrogenase activity
EA665_RS03855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EA665_RS03860	COG1733	regulation of RNA biosynthetic process
EA665_RS03870	COG0531	amino acid
EA665_RS03885	COG0321	lipoyl(octanoyl) transferase activity
EA665_RS03890	COG2921	Belongs to the UPF0250 family
EA665_RS03930	COG2009	succinate dehydrogenase
EA665_RS03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EA665_RS03940	COG1053	succinate dehydrogenase
EA665_RS03945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EA665_RS03970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EA665_RS03990	COG2354	Protein conserved in bacteria
EA665_RS03995	COG2321	neutral zinc metallopeptidase
EA665_RS04015	COG2843	Capsule synthesis protein
EA665_RS04030	COG0589	response to stress
EA665_RS04050	COG0505	Belongs to the CarA family
EA665_RS04075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EA665_RS04080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EA665_RS04130	COG0477	Major facilitator Superfamily
EA665_RS04135	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EA665_RS04150	COG1597	lipid kinase activity
EA665_RS04155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EA665_RS04180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EA665_RS04185	COG0584	glycerophosphoryl diester phosphodiesterase
EA665_RS04205	COG0741	lytic transglycosylase activity
EA665_RS04230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EA665_RS04255	COG3811	Belongs to the UPF0386 family
EA665_RS04280	COG0778	Nitroreductase
EA665_RS04295	COG1929	Belongs to the glycerate kinase type-1 family
EA665_RS04300	COG0243	molybdopterin cofactor binding
EA665_RS04305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EA665_RS04310	COG3339	Conserved Protein
EA665_RS04320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EA665_RS04335	COG1113	amino acid transport
EA665_RS04345	COG0019	diaminopimelate decarboxylase activity
EA665_RS04355	COG1280	lysine exporter protein (LysE YggA)
EA665_RS04360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EA665_RS04390	COG0463	Glycosyl transferase, family 2
EA665_RS04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS04440	COG4591	ABC-type transport system involved in lipoprotein release permease component
EA665_RS04445	COG1136	(ABC) transporter
EA665_RS04450	COG0658	competence protein
EA665_RS04450	COG2333	competence protein COMEC
EA665_RS04460	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EA665_RS04460	COG0616	signal peptide processing
EA665_RS04465	COG0596	Alpha beta hydrolase
EA665_RS04470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EA665_RS04480	COG0628	permease
EA665_RS04500	COG4372	Transposase
EA665_RS04510	COG2963	transposase activity
EA665_RS04520	COG4372	Transposase
EA665_RS04530	COG2963	transposase activity
EA665_RS04555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EA665_RS04575	COG0823	Involved in the tonB-independent uptake of proteins
EA665_RS04595	COG0824	Thioesterase
EA665_RS04600	COG1473	amidohydrolase
EA665_RS04620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EA665_RS04620	COG0047	phosphoribosylformylglycinamidine synthase activity
EA665_RS04625	COG2814	Major facilitator Superfamily
EA665_RS04635	COG1024	Enoyl-CoA hydratase
EA665_RS04640	COG1056	cytidyltransferase-related domain
EA665_RS04640	COG1051	belongs to the nudix hydrolase family
EA665_RS04650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EA665_RS04665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EA665_RS04680	COG4625	pathogenesis
EA665_RS04685	COG0583	DNA-binding transcription factor activity
EA665_RS04690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EA665_RS04695	COG4208	sulfate ABC transporter
EA665_RS04700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EA665_RS04710	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EA665_RS04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EA665_RS04720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EA665_RS04740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EA665_RS04755	COG0681	Belongs to the peptidase S26 family
EA665_RS04770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EA665_RS04780	COG1381	Involved in DNA repair and RecF pathway recombination
EA665_RS04785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EA665_RS04795	COG4221	oxidoreductase activity
EA665_RS04825	COG0443	Heat shock 70 kDa protein
EA665_RS04835	COG0436	Aminotransferase
EA665_RS04855	COG0556	nucleotide-excision repair
EA665_RS04910	COG2070	2-Nitropropane dioxygenase
EA665_RS04940	COG1215	transferase activity, transferring glycosyl groups
EA665_RS04955	COG0415	Belongs to the DNA photolyase family
EA665_RS04965	COG1252	NADH dehydrogenase
EA665_RS04970	COG1686	Belongs to the peptidase S11 family
EA665_RS04985	COG1187	pseudouridine synthase activity
EA665_RS05010	COG0477	Major facilitator Superfamily
EA665_RS05015	COG0583	DNA-binding transcription factor activity
EA665_RS05020	COG1823	symporter activity
EA665_RS05030	COG0612	Peptidase, M16
EA665_RS05055	COG4372	Transposase
EA665_RS05065	COG2963	transposase activity
EA665_RS05075	COG0352	thiamine-phosphate diphosphorylase activity
EA665_RS05110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EA665_RS05120	COG2249	NAD(P)H dehydrogenase (quinone) activity
EA665_RS05135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EA665_RS05140	COG0076	glutamate decarboxylase activity
EA665_RS05150	COG1522	sequence-specific DNA binding
EA665_RS05155	COG3961	Belongs to the TPP enzyme family
EA665_RS05160	COG1113	amino acid transport
EA665_RS05165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EA665_RS05170	COG0573	inorganic phosphate transmembrane transporter activity
EA665_RS05180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EA665_RS05185	COG0616	signal peptide processing
EA665_RS05220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EA665_RS05225	COG1686	Belongs to the peptidase S11 family
EA665_RS05250	COG0583	DNA-binding transcription factor activity
EA665_RS05255	COG1067	ATP-dependent peptidase activity
EA665_RS05280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EA665_RS05300	COG1966	Carbon starvation protein
EA665_RS05305	COG2879	small protein
EA665_RS05350	COG1335	isochorismatase
EA665_RS05355	COG0583	DNA-binding transcription factor activity
EA665_RS05370	COG0596	Alpha beta hydrolase
EA665_RS05380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EA665_RS05390	COG0583	DNA-binding transcription factor activity
EA665_RS05395	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS05400	COG0006	proline dipeptidase activity
EA665_RS05405	COG0477	Major facilitator Superfamily
EA665_RS05420	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS05425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EA665_RS05430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EA665_RS05430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EA665_RS05465	COG2814	Major facilitator Superfamily
EA665_RS05470	COG4948	Mandelate Racemase Muconate Lactonizing
EA665_RS05480	COG2963	transposase activity
EA665_RS05490	COG4372	Transposase
EA665_RS05500	COG1309	transcriptional regulator
EA665_RS05515	COG1741	Belongs to the pirin family
EA665_RS05525	COG2964	Protein conserved in bacteria
EA665_RS05540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EA665_RS05545	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EA665_RS05550	COG4605	iron ion homeostasis
EA665_RS05555	COG4604	ABC transporter, ATP-binding protein
EA665_RS05560	COG4607	ABC-type enterochelin transport system periplasmic component
EA665_RS05565	COG4774	siderophore transport
EA665_RS05575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EA665_RS05580	COG1021	2,3-dihydroxybenzoate-AMP ligase
EA665_RS05585	COG3433	isochorismatase activity
EA665_RS05585	COG1535	isochorismatase
EA665_RS05600	COG1132	(ABC) transporter
EA665_RS05605	COG1132	(ABC) transporter
EA665_RS05610	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EA665_RS05615	COG2977	Belongs to the P-Pant transferase superfamily
EA665_RS05635	COG3739	integral membrane protein
EA665_RS05660	COG0302	gtp cyclohydrolase
EA665_RS05670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EA665_RS05700	COG0308	aminopeptidase N
EA665_RS05705	COG0512	Glutamine amidotransferase of anthranilate synthase
EA665_RS05860	COG3617	BRO family, N-terminal domain
EA665_RS06085	COG2194	sulfuric ester hydrolase activity
EA665_RS06115	COG0006	proline dipeptidase activity
EA665_RS06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA665_RS06125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA665_RS06145	COG1279	arginine transmembrane transporter activity
EA665_RS06150	COG0583	DNA-binding transcription factor activity
EA665_RS06190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EA665_RS06195	COG1388	LysM domain
EA665_RS06195	COG0741	lytic transglycosylase activity
EA665_RS06195	COG1388	LysM domain
EA665_RS06195	COG0741	lytic transglycosylase activity
EA665_RS06205	COG4174	ABC transporter (Permease)
EA665_RS06210	COG4239	(ABC) transporter, permease
EA665_RS06215	COG4172	Belongs to the ABC transporter superfamily
EA665_RS06235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EA665_RS06245	COG5001	Diguanylate cyclase
EA665_RS06245	COG4251	negative regulation of phosphorylation
EA665_RS06245	COG2203	Gaf domain
EA665_RS06245	COG3706	GGDEF domain
EA665_RS06255	COG0446	pyridine nucleotide-disulphide oxidoreductase
EA665_RS06255	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS06270	COG4269	membrane
EA665_RS06310	COG1113	amino acid transport
EA665_RS06320	COG0531	amino acid
EA665_RS06340	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS06360	COG1113	amino acid transport
EA665_RS06375	COG0697	spore germination
EA665_RS06380	COG2721	sulfolactate sulfo-lyase activity
EA665_RS06385	COG2271	Major facilitator Superfamily
EA665_RS06390	COG4948	Mandelate Racemase Muconate Lactonizing
EA665_RS06400	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS06405	COG2186	Transcriptional regulator
EA665_RS06430	COG1960	acyl-CoA dehydrogenase activity
EA665_RS06440	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS06445	COG1024	Enoyl-CoA hydratase
EA665_RS06450	COG2814	Major facilitator Superfamily
EA665_RS06465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EA665_RS06480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EA665_RS06525	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EA665_RS06530	COG2072	flavoprotein involved in K transport
EA665_RS06535	COG0300	oxidoreductase activity
EA665_RS06545	COG1309	transcriptional regulator
EA665_RS06550	COG1741	Belongs to the pirin family
EA665_RS06565	COG2072	flavoprotein involved in K transport
EA665_RS06575	COG2252	PERMEase
EA665_RS06580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EA665_RS06585	COG3038	cytochrome b561
EA665_RS06595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EA665_RS06605	COG0527	aspartate kinase activity
EA665_RS06660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EA665_RS06665	COG4197	protein conserved in bacteria, prophage-related
EA665_RS06815	COG0582	viral genome integration into host DNA
EA665_RS06825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EA665_RS06840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EA665_RS06855	COG0667	Aldo Keto reductase
EA665_RS06865	COG1765	OsmC-like protein
EA665_RS06880	COG0542	response to heat
EA665_RS06915	COG2885	chlorophyll binding
EA665_RS06925	COG0625	glutathione transferase activity
EA665_RS06930	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EA665_RS06950	COG3634	alkyl hydroperoxide reductase activity
EA665_RS06960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EA665_RS06970	COG0450	alkyl hydroperoxide reductase
EA665_RS06975	COG1643	Atp-dependent helicase
EA665_RS06990	COG2814	Major facilitator Superfamily
EA665_RS06995	COG3135	benzoate transporter
EA665_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS07005	COG0633	Ferredoxin
EA665_RS07005	COG0543	2 iron, 2 sulfur cluster binding
EA665_RS07010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EA665_RS07015	COG4638	Rieske (2fe-2S)
EA665_RS07020	COG0583	DNA-binding transcription factor activity
EA665_RS07075	COG1570	exodeoxyribonuclease VII activity
EA665_RS07110	COG1280	lysine exporter protein (LysE YggA)
EA665_RS07115	COG1278	Cold shock
EA665_RS07155	COG2814	Major facilitator Superfamily
EA665_RS07200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EA665_RS07210	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EA665_RS07215	COG1137	ATPase activity
EA665_RS07220	COG1538	Outer membrane efflux protein
EA665_RS07230	COG2963	transposase activity
EA665_RS07240	COG4372	Transposase
EA665_RS07270	COG4122	O-methyltransferase activity
EA665_RS07280	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EA665_RS07295	COG1522	sequence-specific DNA binding
EA665_RS07310	COG1560	Kdo2-lipid A biosynthetic process
EA665_RS07325	COG2814	Major facilitator Superfamily
EA665_RS07345	COG1250	3-hydroxyacyl-CoA dehydrogenase
EA665_RS07380	COG0583	DNA-binding transcription factor activity
EA665_RS07385	COG1914	H( )-stimulated, divalent metal cation uptake system
EA665_RS07405	COG4770	biotin carboxylase activity
EA665_RS07410	COG0038	chloride channel
EA665_RS07415	COG2831	hemolysin activation secretion protein
EA665_RS07420	COG3210	domain, Protein
EA665_RS07450	COG1063	alcohol dehydrogenase
EA665_RS07465	COG0439	Biotin carboxylase
EA665_RS07470	COG2249	NAD(P)H dehydrogenase (quinone) activity
EA665_RS07475	COG1733	regulation of RNA biosynthetic process
EA665_RS07490	COG0864	Transcriptional regulator
EA665_RS07500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EA665_RS07505	COG1116	anion transmembrane transporter activity
EA665_RS07625	COG0590	tRNA wobble adenosine to inosine editing
EA665_RS07630	COG2807	transmembrane transport
EA665_RS07645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EA665_RS07655	COG0789	Transcriptional regulator
EA665_RS07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EA665_RS07690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EA665_RS07715	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS07720	COG0531	amino acid
EA665_RS07725	COG1760	l-serine dehydratase
EA665_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS07730	COG2030	dehydratase
EA665_RS07735	COG3396	Phenylacetate-CoA oxygenase
EA665_RS07740	COG3460	Phenylacetate-CoA oxygenase
EA665_RS07745	COG3396	Phenylacetate-CoA oxygenase
EA665_RS07750	COG2151	metal-sulfur cluster biosynthetic enzyme
EA665_RS07755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EA665_RS07760	COG1024	Enoyl-CoA hydratase
EA665_RS07765	COG1024	Enoyl-CoA hydratase
EA665_RS07770	COG1250	3-hydroxyacyl-CoA dehydrogenase
EA665_RS07775	COG0183	Belongs to the thiolase family
EA665_RS07780	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EA665_RS07785	COG3327	negative regulation of DNA-templated transcription, initiation
EA665_RS07795	COG2050	protein possibly involved in aromatic compounds catabolism
EA665_RS07830	COG0753	catalase activity
EA665_RS07835	COG3038	cytochrome b561
EA665_RS07855	COG2267	carboxylic ester hydrolase activity
EA665_RS07860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS07865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EA665_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS07880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EA665_RS07890	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS07895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EA665_RS07900	COG0583	DNA-binding transcription factor activity
EA665_RS07910	COG1414	Transcriptional regulator
EA665_RS07915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA665_RS07925	COG1840	ABC-type Fe3 transport system, periplasmic component
EA665_RS07930	COG3842	ATPase activity
EA665_RS07945	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EA665_RS07950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EA665_RS07955	COG2814	Major facilitator Superfamily
EA665_RS07960	COG1960	acyl-CoA dehydrogenase activity
EA665_RS07965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EA665_RS07975	COG1024	Enoyl-CoA hydratase
EA665_RS07985	COG2814	Major facilitator Superfamily
EA665_RS07995	COG0183	Belongs to the thiolase family
EA665_RS08000	COG1250	3-hydroxyacyl-CoA dehydrogenase
EA665_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS08010	COG1024	Enoyl-CoA hydratase
EA665_RS08015	COG1960	acyl-CoA dehydrogenase activity
EA665_RS08020	COG2814	Major facilitator Superfamily
EA665_RS08025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EA665_RS08030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EA665_RS08040	COG2814	Major facilitator Superfamily
EA665_RS08050	COG1960	acyl-CoA dehydrogenase activity
EA665_RS08065	COG0583	DNA-binding transcription factor activity
EA665_RS08075	COG4770	biotin carboxylase activity
EA665_RS08080	COG1024	Enoyl-CoA hydratase
EA665_RS08085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EA665_RS08090	COG1960	acyl-CoA dehydrogenase activity
EA665_RS08095	COG1309	transcriptional regulator
EA665_RS08100	COG0318	PFAM AMP-dependent synthetase and ligase
EA665_RS08120	COG0583	DNA-binding transcription factor activity
EA665_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS08185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EA665_RS08205	COG0784	Response regulator, receiver
EA665_RS08205	COG2205	protein histidine kinase activity
EA665_RS08225	COG0765	amino acid transport
EA665_RS08230	COG0765	amino acid transport
EA665_RS08235	COG1126	abc transporter atp-binding protein
EA665_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EA665_RS08245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EA665_RS08260	COG1280	lysine exporter protein (LysE YggA)
EA665_RS08265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EA665_RS08270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EA665_RS08275	COG1045	serine acetyltransferase
EA665_RS08290	COG0583	DNA-binding transcription factor activity
EA665_RS08295	COG0625	glutathione transferase activity
EA665_RS08300	COG0625	glutathione transferase activity
EA665_RS08305	COG0583	DNA-binding transcription factor activity
EA665_RS08315	COG1346	cytolysis
EA665_RS08335	COG2814	Major facilitator Superfamily
EA665_RS08345	COG0583	DNA-binding transcription factor activity
EA665_RS08355	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EA665_RS08360	COG3052	prosthetic group binding
EA665_RS08380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EA665_RS08400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EA665_RS08410	COG1294	oxidase, subunit
EA665_RS08415	COG1271	oxidase subunit
EA665_RS08440	COG0477	Major facilitator Superfamily
EA665_RS08460	COG4521	taurine ABC transporter
EA665_RS08465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EA665_RS08470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EA665_RS08475	COG2175	clavaminate synthase activity
EA665_RS08485	COG1953	Uracil, thiamine, allantoin
EA665_RS08495	COG0583	DNA-binding transcription factor activity
EA665_RS08505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EA665_RS08520	COG0640	Transcriptional regulator
EA665_RS08525	COG0798	PFAM Bile acid sodium symporter
EA665_RS08530	COG0583	DNA-binding transcription factor activity
EA665_RS08545	COG3634	alkyl hydroperoxide reductase activity
EA665_RS08585	COG0436	Aminotransferase
EA665_RS08595	COG0386	Belongs to the glutathione peroxidase family
EA665_RS08635	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EA665_RS08660	COG0012	GTP binding
EA665_RS08665	COG2011	ABC-type metal ion transport system permease component
EA665_RS08670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EA665_RS08680	COG1464	Belongs to the NlpA lipoprotein family
EA665_RS08710	COG0765	amino acid transport
EA665_RS08715	COG0765	amino acid transport
EA665_RS08720	COG1126	abc transporter atp-binding protein
EA665_RS08730	COG1522	sequence-specific DNA binding
EA665_RS08745	COG1309	transcriptional regulator
EA665_RS08765	COG0583	DNA-binding transcription factor activity
EA665_RS08775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EA665_RS08785	COG0697	spore germination
EA665_RS08815	COG3121	Chaperone
EA665_RS08820	COG3539	Fimbrial protein
EA665_RS08845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EA665_RS08845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EA665_RS08895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EA665_RS08905	COG2353	YceI-like domain
EA665_RS08915	COG3698	Phosphodiester glycosidase
EA665_RS08930	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EA665_RS08935	COG0506	proline dehydrogenase activity
EA665_RS08935	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EA665_RS08935	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EA665_RS08945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EA665_RS08950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EA665_RS08970	COG1132	(ABC) transporter
EA665_RS08975	COG3122	Protein conserved in bacteria
EA665_RS08980	COG3619	membrane
EA665_RS08990	COG0640	Transcriptional regulator
EA665_RS09000	COG2850	peptidyl-arginine hydroxylation
EA665_RS09005	COG0424	maF-like protein
EA665_RS09025	COG0191	fructose-bisphosphate aldolase activity
EA665_RS09030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EA665_RS09045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EA665_RS09055	COG1192	Involved in chromosome partitioning
EA665_RS09060	COG1475	DNA binding
EA665_RS09065	COG0811	peptide transport
EA665_RS09075	COG1132	(ABC) transporter
EA665_RS09080	COG1663	tetraacyldisaccharide 4'-kinase activity
EA665_RS09100	COG0084	hydrolase, TatD family'
EA665_RS09165	COG0776	regulation of translation
EA665_RS09195	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EA665_RS09200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EA665_RS09250	COG0339	signal peptide processing
EA665_RS09260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EA665_RS09295	COG0702	epimerase
EA665_RS09300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EA665_RS09320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EA665_RS09350	COG0316	Belongs to the HesB IscA family
EA665_RS09355	COG0822	iron-sulfur transferase activity
EA665_RS09380	COG0776	regulation of translation
EA665_RS09385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EA665_RS09390	COG2207	Transcriptional regulator
EA665_RS09395	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EA665_RS09400	COG1960	acyl-CoA dehydrogenase activity
EA665_RS09405	COG1960	acyl-CoA dehydrogenase activity
EA665_RS09420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EA665_RS09440	COG4264	IucA IucC family
EA665_RS09445	COG4264	IucA IucC family
EA665_RS09455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EA665_RS09485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EA665_RS09500	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EA665_RS09520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EA665_RS09525	COG0730	response to heat
EA665_RS09545	COG4773	Receptor
EA665_RS09550	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EA665_RS09565	COG1131	(ABC) transporter
EA665_RS09570	COG0842	Transport permease protein
EA665_RS09575	COG0842	Transport permease protein
EA665_RS09595	COG2963	transposase activity
EA665_RS09605	COG4372	Transposase
EA665_RS09645	COG2226	methyltransferase
EA665_RS09670	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EA665_RS09705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EA665_RS09715	COG0133	tryptophan synthase activity
EA665_RS09730	COG2963	transposase activity
EA665_RS09740	COG4372	Transposase
EA665_RS09745	COG3706	GGDEF domain
EA665_RS09760	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EA665_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EA665_RS09770	COG0022	dehydrogenase e1 component
EA665_RS09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
EA665_RS09780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EA665_RS09790	COG1063	alcohol dehydrogenase
EA665_RS09795	COG3781	membrane
EA665_RS09805	COG3453	Protein conserved in bacteria
EA665_RS09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EA665_RS09815	COG0730	response to heat
EA665_RS09830	COG3708	Transcriptional regulator
EA665_RS09830	COG2207	Transcriptional regulator
EA665_RS09835	COG1733	regulation of RNA biosynthetic process
EA665_RS09840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EA665_RS09850	COG2188	Transcriptional regulator
EA665_RS09865	COG4521	taurine ABC transporter
EA665_RS09890	COG0477	Major facilitator Superfamily
EA665_RS09900	COG1027	Aspartate ammonia-lyase
EA665_RS09915	COG0583	DNA-binding transcription factor activity
EA665_RS09920	COG0583	DNA-binding transcription factor activity
EA665_RS09925	COG0183	Belongs to the thiolase family
EA665_RS09930	COG2031	fatty acid transporter
EA665_RS09945	COG0583	DNA-binding transcription factor activity
EA665_RS09965	COG1309	transcriptional regulator
EA665_RS09975	COG2610	gluconate transmembrane transporter activity
EA665_RS09980	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS09985	COG2207	Transcriptional regulator
EA665_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS10010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS10025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EA665_RS10025	COG0543	2 iron, 2 sulfur cluster binding
EA665_RS10030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EA665_RS10035	COG4638	Rieske (2fe-2S)
EA665_RS10045	COG0725	ABC transporter, periplasmic molybdate-binding protein
EA665_RS10050	COG4149	molybdate abc transporter
EA665_RS10055	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EA665_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS10065	COG1535	isochorismatase
EA665_RS10065	COG3433	isochorismatase activity
EA665_RS10135	COG2963	transposase activity
EA665_RS10145	COG4372	Transposase
EA665_RS10165	COG0753	catalase activity
EA665_RS10175	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EA665_RS10230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EA665_RS10235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS10240	COG0745	RESPONSE REGULATOR receiver
EA665_RS10250	COG2963	transposase activity
EA665_RS10260	COG4372	Transposase
EA665_RS10275	COG2207	Transcriptional regulator
EA665_RS10290	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS10295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EA665_RS10300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EA665_RS10305	COG2851	Citrate transporter
EA665_RS10310	COG1414	Transcriptional regulator
EA665_RS10320	COG0583	DNA-binding transcription factor activity
EA665_RS10330	COG0477	Major facilitator Superfamily
EA665_RS10360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EA665_RS10400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EA665_RS10450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EA665_RS10470	COG1120	ATPase activity
EA665_RS10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EA665_RS10485	COG1064	alcohol dehydrogenase
EA665_RS10500	COG2207	Transcriptional regulator
EA665_RS10505	COG2084	Dehydrogenase
EA665_RS10515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EA665_RS10520	COG0583	DNA-binding transcription factor activity
EA665_RS10530	COG0129	dihydroxy-acid dehydratase activity
EA665_RS10535	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS10550	COG1566	PFAM secretion protein HlyD family protein
EA665_RS10575	COG0583	DNA-binding transcription factor activity
EA665_RS10590	COG2188	Transcriptional regulator
EA665_RS10625	COG4191	Histidine kinase
EA665_RS10645	COG1473	amidohydrolase
EA665_RS10655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EA665_RS10655	COG0475	glutathione-regulated potassium exporter activity
EA665_RS10665	COG0583	DNA-binding transcription factor activity
EA665_RS10670	COG1335	isochorismatase
EA665_RS10680	COG1309	transcriptional regulator
EA665_RS10720	COG0446	pyridine nucleotide-disulphide oxidoreductase
EA665_RS10720	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS10735	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS10755	COG2186	Transcriptional regulator
EA665_RS10765	COG0583	DNA-binding transcription factor activity
EA665_RS10770	COG4948	Mandelate Racemase Muconate Lactonizing
EA665_RS10775	COG4829	muconolactone delta-isomerase
EA665_RS10785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EA665_RS10790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EA665_RS10795	COG0183	Belongs to the thiolase family
EA665_RS10800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EA665_RS10810	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS10820	COG3733	amine oxidase
EA665_RS10830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS10840	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS10850	COG4638	Rieske (2fe-2S)
EA665_RS10870	COG0154	amidase activity
EA665_RS10880	COG2814	Major facilitator Superfamily
EA665_RS10905	COG1960	acyl-CoA dehydrogenase activity
EA665_RS10910	COG0583	DNA-binding transcription factor activity
EA665_RS10915	COG1414	Transcriptional regulator
EA665_RS10930	COG2391	methyltransferase activity
EA665_RS10940	COG4993	Dehydrogenase
EA665_RS10945	COG3659	wide pore channel activity
EA665_RS10950	COG3420	alginic acid biosynthetic process
EA665_RS10955	COG0710	3-dehydroquinate dehydratase activity
EA665_RS10960	COG3485	protocatechuate 3,4-dioxygenase
EA665_RS10965	COG3485	protocatechuate 3,4-dioxygenase
EA665_RS10970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EA665_RS10975	COG2271	Major facilitator Superfamily
EA665_RS10980	COG0596	Alpha beta hydrolase
EA665_RS10985	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EA665_RS10990	COG0183	Belongs to the thiolase family
EA665_RS10995	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EA665_RS11000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EA665_RS11010	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EA665_RS11015	COG2323	membrane
EA665_RS11060	COG1902	pentaerythritol trinitrate reductase activity
EA665_RS11060	COG0446	pyridine nucleotide-disulphide oxidoreductase
EA665_RS11085	COG0542	response to heat
EA665_RS11090	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EA665_RS11120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EA665_RS11125	COG0569	domain protein
EA665_RS11130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EA665_RS11145	COG4774	siderophore transport
EA665_RS11150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EA665_RS11160	COG1585	Membrane protein implicated in regulation of membrane protease activity
EA665_RS11165	COG2963	transposase activity
EA665_RS11175	COG4372	Transposase
EA665_RS11190	COG1294	oxidase, subunit
EA665_RS11195	COG4890	Cyd operon protein YbgT
EA665_RS11205	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EA665_RS11215	COG0552	protein localization to endoplasmic reticulum
EA665_RS11240	COG0516	GMP reductase activity
EA665_RS11240	COG0517	IMP dehydrogenase activity
EA665_RS11245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EA665_RS11250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EA665_RS11260	COG0583	DNA-binding transcription factor activity
EA665_RS11265	COG0024	Methionine aminopeptidase
EA665_RS11295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EA665_RS11295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EA665_RS11300	COG1105	Belongs to the carbohydrate kinase PfkB family
EA665_RS11305	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EA665_RS11305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EA665_RS11305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EA665_RS11320	COG5001	Diguanylate cyclase
EA665_RS11320	COG3300	MHYT domain
EA665_RS11330	COG4372	Transposase
EA665_RS11340	COG2963	transposase activity
EA665_RS11355	COG2135	peptidase activity
EA665_RS11360	COG0659	secondary active sulfate transmembrane transporter activity
EA665_RS11375	COG1113	amino acid transport
EA665_RS11385	COG1522	sequence-specific DNA binding
EA665_RS11410	COG1011	Hydrolase
EA665_RS11415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EA665_RS11425	COG2137	regulation of response to DNA damage stimulus
EA665_RS11440	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EA665_RS11475	COG0575	Belongs to the CDS family
EA665_RS11480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EA665_RS11505	COG3852	Histidine kinase
EA665_RS11510	COG2204	response regulator
EA665_RS11585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EA665_RS11590	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EA665_RS11610	COG0697	spore germination
EA665_RS11615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EA665_RS11625	COG0303	'Molybdopterin
EA665_RS11630	COG0521	Mo-molybdopterin cofactor biosynthetic process
EA665_RS11630	COG0315	cyclic pyranopterin monophosphate synthase activity
EA665_RS11645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EA665_RS11650	COG0243	molybdopterin cofactor binding
EA665_RS11660	COG0243	molybdopterin cofactor binding
EA665_RS11665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EA665_RS11670	COG2146	nitrite reductase [NAD(P)H] activity
EA665_RS11670	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EA665_RS11680	COG0745	RESPONSE REGULATOR receiver
EA665_RS11685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EA665_RS11685	COG1116	anion transmembrane transporter activity
EA665_RS11700	COG0511	ligase activity, forming carbon-carbon bonds
EA665_RS11715	COG2814	Major facilitator Superfamily
EA665_RS11805	COG2963	transposase activity
EA665_RS11815	COG4372	Transposase
EA665_RS11850	COG0592	DNA-directed DNA polymerase activity
EA665_RS11895	COG2026	Addiction module toxin, RelE StbE family
EA665_RS12050	COG2963	transposase activity
EA665_RS12060	COG4372	Transposase
EA665_RS12105	COG1484	DNA-dependent DNA replication
EA665_RS12200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EA665_RS12250	COG0069	glutamate synthase activity
EA665_RS12270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EA665_RS12280	COG1454	alcohol dehydrogenase
EA665_RS12285	COG0824	Thioesterase
EA665_RS12295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EA665_RS12310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EA665_RS12315	COG2030	dehydratase
EA665_RS12325	COG0183	Belongs to the thiolase family
EA665_RS12335	COG0583	DNA-binding transcription factor activity
EA665_RS12340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EA665_RS12350	COG4372	Transposase
EA665_RS12360	COG2963	transposase activity
EA665_RS12370	COG1522	sequence-specific DNA binding
EA665_RS12375	COG3135	benzoate transporter
EA665_RS12385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EA665_RS12400	COG0589	response to stress
EA665_RS12405	COG0488	(ABC) transporter
EA665_RS12425	COG4773	Receptor
EA665_RS12455	COG0668	transmembrane transport
EA665_RS12465	COG1309	transcriptional regulator
EA665_RS12490	COG1605	Chorismate mutase
EA665_RS12530	COG0308	aminopeptidase N
EA665_RS12550	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EA665_RS12560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EA665_RS12565	COG1454	alcohol dehydrogenase
EA665_RS12585	COG0531	amino acid
EA665_RS12590	COG4303	Ethanolamine ammonia lyase large subunit
EA665_RS12595	COG4302	ethanolamine ammonia-lyase activity
EA665_RS12600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EA665_RS12600	COG0519	Catalyzes the synthesis of GMP from XMP
EA665_RS12605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EA665_RS12615	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EA665_RS12630	COG0697	spore germination
EA665_RS12635	COG1923	regulation of RNA biosynthetic process
EA665_RS12645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EA665_RS12650	COG0802	atpase or kinase
EA665_RS12670	COG1187	pseudouridine synthase activity
EA665_RS12685	COG0583	DNA-binding transcription factor activity
EA665_RS12700	COG2814	Major facilitator Superfamily
EA665_RS12705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EA665_RS12735	COG0729	surface antigen
EA665_RS12755	COG0174	glutamine synthetase
EA665_RS12760	COG0745	RESPONSE REGULATOR receiver
EA665_RS12765	COG2205	protein histidine kinase activity
EA665_RS12775	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EA665_RS12780	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EA665_RS12790	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EA665_RS12805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS12810	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EA665_RS12815	COG1960	acyl-CoA dehydrogenase activity
EA665_RS12845	COG0583	DNA-binding transcription factor activity
EA665_RS12865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EA665_RS12875	COG3658	cytochrome
EA665_RS12880	COG1215	transferase activity, transferring glycosyl groups
EA665_RS12885	COG1649	PFAM Uncharacterised BCR, COG1649
EA665_RS12885	COG0726	polysaccharide deacetylase
EA665_RS12910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EA665_RS12915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EA665_RS12925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EA665_RS12950	COG0305	Participates in initiation and elongation during chromosome replication
EA665_RS12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EA665_RS12965	COG1305	Transglutaminase-like
EA665_RS12975	COG2308	Evidence 4 Homologs of previously reported genes of
EA665_RS13005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EA665_RS13010	COG0138	bifunctional purine biosynthesis protein purh
EA665_RS13015	COG0151	Belongs to the GarS family
EA665_RS13020	COG1464	Belongs to the NlpA lipoprotein family
EA665_RS13025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EA665_RS13030	COG2011	ABC-type metal ion transport system permease component
EA665_RS13035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EA665_RS13045	COG1301	dicarboxylic acid transport
EA665_RS13080	COG1794	racemase activity, acting on amino acids and derivatives
EA665_RS13090	COG3008	intermembrane lipid transfer
EA665_RS13090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EA665_RS13095	COG2995	paraquat-inducible protein a
EA665_RS13125	COG1051	belongs to the nudix hydrolase family
EA665_RS13130	COG0477	Major facilitator Superfamily
EA665_RS13180	COG2186	Transcriptional regulator
EA665_RS13190	COG0786	glutamate:sodium symporter activity
EA665_RS13195	COG3243	poly(R)-hydroxyalkanoic acid synthase
EA665_RS13220	COG3111	PFAM Bacterial OB fold (BOF) protein
EA665_RS13320	COG2831	hemolysin activation secretion protein
EA665_RS13345	COG0515	serine threonine protein kinase
EA665_RS13345	COG2815	serine threonine protein kinase
EA665_RS13375	COG1610	YqeY-like protein
EA665_RS13380	COG4783	chaperone-mediated protein folding
EA665_RS13405	COG1286	toxin biosynthetic process
EA665_RS13435	COG0778	Nitroreductase
EA665_RS13445	COG0513	Belongs to the DEAD box helicase family
EA665_RS13465	COG2363	Small membrane protein
EA665_RS13495	COG1234	tRNA 3'-trailer cleavage
EA665_RS13500	COG2195	Cleaves the N-terminal amino acid of tripeptides
EA665_RS13510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EA665_RS13520	COG2819	hydrolase of the alpha beta superfamily
EA665_RS13525	COG1960	acyl-CoA dehydrogenase activity
EA665_RS13530	COG1301	dicarboxylic acid transport
EA665_RS13540	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EA665_RS13545	COG3139	Protein of unknown function (DUF1315)
EA665_RS13550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EA665_RS13555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EA665_RS13565	COG0494	nUDIX hydrolase
EA665_RS13575	COG0642	Histidine kinase
EA665_RS13590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EA665_RS13600	COG1720	tRNA m6t6A37 methyltransferase activity
EA665_RS13610	COG0384	phenazine biosynthesis protein PhzF
EA665_RS13615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EA665_RS13620	COG0826	peptidase U32
EA665_RS13625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EA665_RS13635	COG4598	ABC transporter
EA665_RS13640	COG4160	amino acid transport
EA665_RS13645	COG4215	(ABC) transporter
EA665_RS13660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS13705	COG1131	(ABC) transporter
EA665_RS13710	COG0842	Transport permease protein
EA665_RS13725	COG0772	Belongs to the SEDS family
EA665_RS13730	COG2951	lytic endotransglycosylase activity
EA665_RS13755	COG2207	Transcriptional regulator
EA665_RS13770	COG0052	Belongs to the universal ribosomal protein uS2 family
EA665_RS13775	COG0024	Methionine aminopeptidase
EA665_RS13785	COG2223	nitrite transmembrane transporter activity
EA665_RS13795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EA665_RS13800	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EA665_RS13805	COG1960	acyl-CoA dehydrogenase activity
EA665_RS13820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EA665_RS13825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EA665_RS13830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EA665_RS13850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EA665_RS13855	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EA665_RS13860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EA665_RS13895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EA665_RS13905	COG0174	glutamine synthetase
EA665_RS13920	COG0582	viral genome integration into host DNA
EA665_RS14295	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EA665_RS14320	COG3384	dioxygenase
EA665_RS14330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EA665_RS14335	COG2878	Part of a membrane complex involved in electron transport
EA665_RS14340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EA665_RS14365	COG0768	penicillin binding
EA665_RS14370	COG0742	ribosomal rna small subunit methyltransferase
EA665_RS14385	COG0830	nickel cation binding
EA665_RS14395	COG0804	urea catabolic process
EA665_RS14435	COG1253	flavin adenine dinucleotide binding
EA665_RS14445	COG2851	Citrate transporter
EA665_RS14495	COG1773	rubredoxin
EA665_RS14500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EA665_RS14510	COG0583	DNA-binding transcription factor activity
EA665_RS14540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EA665_RS14545	COG4181	ATPase activity
EA665_RS14590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EA665_RS14610	COG0306	phosphate transporter
EA665_RS14620	COG3958	Transketolase
EA665_RS14625	COG3959	Transketolase, thiamine diphosphate binding domain
EA665_RS14630	COG2271	Major facilitator Superfamily
EA665_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS14640	COG0583	DNA-binding transcription factor activity
EA665_RS14660	COG2223	nitrite transmembrane transporter activity
EA665_RS14665	COG2207	Transcriptional regulator
EA665_RS14670	COG2066	Belongs to the glutaminase family
EA665_RS14675	COG0242	peptide deformylase activity
EA665_RS14680	COG0477	Major facilitator Superfamily
EA665_RS14690	COG0028	Belongs to the TPP enzyme family
EA665_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS14710	COG2267	carboxylic ester hydrolase activity
EA665_RS14720	COG2271	Major facilitator Superfamily
EA665_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS14755	COG1414	Transcriptional regulator
EA665_RS14770	COG1024	Enoyl-CoA hydratase
EA665_RS14780	COG1215	transferase activity, transferring glycosyl groups
EA665_RS14785	COG0726	polysaccharide deacetylase
EA665_RS14785	COG1649	PFAM Uncharacterised BCR, COG1649
EA665_RS14795	COG4681	YaeQ
EA665_RS14805	COG0523	cobalamin synthesis protein
EA665_RS14815	COG1607	acyl-coa hydrolase
EA665_RS14825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EA665_RS14830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EA665_RS14835	COG1309	transcriptional regulator
EA665_RS14860	COG2040	homocysteine
EA665_RS14865	COG0531	amino acid
EA665_RS14915	COG0477	Major facilitator Superfamily
EA665_RS14950	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EA665_RS14965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EA665_RS14970	COG2963	transposase activity
EA665_RS14980	COG4372	Transposase
EA665_RS15025	COG0629	single-stranded DNA binding
EA665_RS15070	COG0582	viral genome integration into host DNA
EA665_RS15080	COG0405	Gamma-glutamyltransferase
EA665_RS15085	COG2814	Major facilitator Superfamily
EA665_RS15095	COG2050	protein possibly involved in aromatic compounds catabolism
EA665_RS15110	COG1090	epimerase
EA665_RS15130	COG0420	3'-5' exonuclease activity
EA665_RS15155	COG0735	belongs to the Fur family
EA665_RS15160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EA665_RS15185	COG0121	glutamine amidotransferase
EA665_RS15200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EA665_RS15210	COG0210	DNA helicase
EA665_RS15215	COG2885	chlorophyll binding
EA665_RS15220	COG0204	Acyl-transferase
EA665_RS15235	COG2894	cell division
EA665_RS15250	COG1280	lysine exporter protein (LysE YggA)
EA665_RS15255	COG1674	ftsk spoiiie
EA665_RS15255	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EA665_RS15260	COG0492	ferredoxin-NADP+ reductase activity
EA665_RS15265	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EA665_RS15275	COG0456	acetyltransferase
EA665_RS15320	COG1981	membrane
EA665_RS15335	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EA665_RS15335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EA665_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS15365	COG0657	acetylesterase activity
EA665_RS15375	COG0473	3-isopropylmalate dehydrogenase activity
EA665_RS15380	COG0583	DNA-binding transcription factor activity
EA665_RS15400	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EA665_RS15425	COG0564	pseudouridine synthase activity
EA665_RS15435	COG0358	DNA primase activity
EA665_RS15450	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EA665_RS15480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EA665_RS15510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EA665_RS15520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EA665_RS15520	COG0352	thiamine-phosphate diphosphorylase activity
EA665_RS15520	COG0351	phosphomethylpyrimidine kinase
EA665_RS15525	COG1652	LysM domain
EA665_RS15550	COG1399	metal-binding, possibly nucleic acid-binding protein
EA665_RS15555	COG3101	peptidyl-lysine hydroxylation
EA665_RS15560	COG0009	L-threonylcarbamoyladenylate synthase
EA665_RS15565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EA665_RS15570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EA665_RS15585	COG4106	trans-aconitate 2-methyltransferase activity
EA665_RS15600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EA665_RS15600	COG0596	Alpha beta hydrolase
EA665_RS15600	COG2226	methyltransferase
EA665_RS15605	COG1877	trehalose-phosphatase activity
EA665_RS15610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EA665_RS15615	COG2223	nitrite transmembrane transporter activity
EA665_RS15635	COG1196	nuclear chromosome segregation
EA665_RS15645	COG0730	response to heat
EA665_RS15660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EA665_RS15670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EA665_RS15730	COG0489	protein tyrosine kinase activity
EA665_RS15740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EA665_RS15740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EA665_RS15770	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EA665_RS15775	COG2081	HI0933 family
EA665_RS15785	COG0668	transmembrane transport
EA665_RS15805	COG0583	DNA-binding transcription factor activity
EA665_RS15830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EA665_RS15835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EA665_RS15865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EA665_RS15890	COG3706	GGDEF domain
EA665_RS15905	COG0745	RESPONSE REGULATOR receiver
EA665_RS15925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EA665_RS15980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EA665_RS15995	COG0583	DNA-binding transcription factor activity
EA665_RS16005	COG0583	DNA-binding transcription factor activity
EA665_RS16025	COG0583	DNA-binding transcription factor activity
EA665_RS16030	COG1053	succinate dehydrogenase
EA665_RS16045	COG1309	transcriptional regulator
EA665_RS16050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EA665_RS16055	COG2814	Major facilitator Superfamily
EA665_RS16060	COG1960	acyl-CoA dehydrogenase activity
EA665_RS16065	COG0583	DNA-binding transcription factor activity
EA665_RS16070	COG1063	alcohol dehydrogenase
EA665_RS16105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EA665_RS16110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EA665_RS16115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EA665_RS16135	COG2132	Multicopper oxidase
EA665_RS16145	COG0561	phosphatase activity
EA665_RS16150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EA665_RS16175	COG1214	PFAM Peptidase M22, glycoprotease
EA665_RS16205	COG4372	Transposase
EA665_RS16215	COG2963	transposase activity
EA665_RS16245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EA665_RS16255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EA665_RS16260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EA665_RS16265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EA665_RS16325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EA665_RS16335	COG1846	Transcriptional regulator
EA665_RS16340	COG1764	response to oxidative stress
EA665_RS16380	COG0037	tRNA processing
EA665_RS16390	COG0248	Ppx GppA phosphatase
EA665_RS16420	COG0072	phenylalanine-tRNA ligase activity
EA665_RS16460	COG1238	metal cluster binding
EA665_RS16465	COG0625	glutathione transferase activity
EA665_RS16485	COG0318	PFAM AMP-dependent synthetase and ligase
EA665_RS16490	COG3028	Belongs to the UPF0307 family
EA665_RS16495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EA665_RS16515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EA665_RS16520	COG0617	tRNA 3'-terminal CCA addition
EA665_RS16525	COG1555	photosystem II stabilization
EA665_RS16530	COG3956	TIGRFAM MazG family protein
EA665_RS16540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EA665_RS16560	COG0784	Response regulator, receiver
EA665_RS16560	COG2205	protein histidine kinase activity
EA665_RS16560	COG5002	protein histidine kinase activity
EA665_RS16565	COG1024	Enoyl-CoA hydratase
EA665_RS16570	COG2084	Dehydrogenase
EA665_RS16575	COG3622	Belongs to the hyi family
EA665_RS16605	COG0697	spore germination
EA665_RS16615	COG2814	Major facilitator Superfamily
EA665_RS16620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EA665_RS16630	COG0583	DNA-binding transcription factor activity
EA665_RS16640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EA665_RS16650	COG0084	hydrolase, TatD family'
EA665_RS16665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EA665_RS16700	COG0440	acetolactate synthase activity
EA665_RS16705	COG0028	Belongs to the TPP enzyme family
EA665_RS16735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EA665_RS16740	COG0577	efflux transmembrane transporter activity
EA665_RS16740	COG1136	(ABC) transporter
EA665_RS16745	COG1538	Outer membrane efflux protein
EA665_RS16760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EA665_RS16765	COG1162	GTPase activity
EA665_RS16775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EA665_RS16815	COG1426	Protein conserved in bacteria
EA665_RS16850	COG0793	Belongs to the peptidase S41A family
EA665_RS16865	COG2267	carboxylic ester hydrolase activity
EA665_RS16875	COG1012	belongs to the aldehyde dehydrogenase family
EA665_RS16880	COG3265	gluconokinase activity
EA665_RS16890	COG0800	Aldolase
EA665_RS16900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EA665_RS16905	COG0280	phosphate acetyltransferase
EA665_RS16905	COG0857	belongs to the CobB CobQ family
EA665_RS16910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EA665_RS16910	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EA665_RS16930	COG0740	serine-type endopeptidase activity
EA665_RS16940	COG4774	siderophore transport
EA665_RS16950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EA665_RS16960	COG2813	Specifically methylates the guanine in position
EA665_RS16960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EA665_RS17060	COG0788	formyltetrahydrofolate deformylase activity
EA665_RS17085	COG4651	solute:proton antiporter activity
EA665_RS17085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EA665_RS17105	COG0724	RNA recognition motif
EA665_RS17110	COG0210	DNA helicase
EA665_RS17135	COG1733	regulation of RNA biosynthetic process
EA665_RS17145	COG2900	Belongs to the SlyX family
EA665_RS17150	COG0488	(ABC) transporter
EA665_RS17155	COG1280	lysine exporter protein (LysE YggA)
EA665_RS17160	COG1560	Kdo2-lipid A biosynthetic process
EA665_RS17170	COG1301	dicarboxylic acid transport
EA665_RS17225	COG0473	3-isopropylmalate dehydrogenase activity
EA665_RS17290	COG0583	DNA-binding transcription factor activity
EA665_RS17300	COG0625	glutathione transferase activity
EA665_RS17305	COG2378	regulation of single-species biofilm formation
EA665_RS17310	COG0546	phosphoglycolate phosphatase activity
EA665_RS17325	COG1530	ribonuclease E activity
EA665_RS17330	COG0318	PFAM AMP-dependent synthetase and ligase
EA665_RS17345	COG0583	DNA-binding transcription factor activity
EA665_RS17350	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS17355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EA665_RS17365	COG0534	Mate efflux family protein
EA665_RS17380	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EA665_RS17390	COG4372	Transposase
EA665_RS17400	COG2963	transposase activity
EA665_RS17425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EA665_RS17425	COG0493	'glutamate synthase
EA665_RS17435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EA665_RS17440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EA665_RS17455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EA665_RS17465	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EA665_RS17465	COG0644	oxidoreductase
EA665_RS17475	COG0425	Belongs to the sulfur carrier protein TusA family
EA665_RS17480	COG4535	Mg2 and Co2 transporter CorC
EA665_RS17490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EA665_RS17510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EA665_RS17515	COG0475	glutathione-regulated potassium exporter activity
EA665_RS17515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EA665_RS17530	COG0484	heat shock protein binding
EA665_RS17535	COG0789	Transcriptional regulator
EA665_RS17540	COG0598	Magnesium transport protein CorA
EA665_RS17555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EA665_RS17560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EA665_RS17565	COG1074	ATP-dependent DNA helicase activity
EA665_RS17570	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EA665_RS17590	COG2226	methyltransferase
EA665_RS17605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EA665_RS17610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EA665_RS17625	COG2111	Na H antiporter
EA665_RS17625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EA665_RS17630	COG1006	Multisubunit Na H antiporter MnhC subunit
EA665_RS17635	COG0651	ATP synthesis coupled electron transport
EA665_RS17640	COG1863	multisubunit Na H antiporter MnhE subunit
EA665_RS17645	COG2212	antiporter activity
EA665_RS17650	COG1320	monovalent cation:proton antiporter activity
EA665_RS17665	COG0195	Participates in both transcription termination and antitermination
EA665_RS17715	COG0237	dephospho-CoA kinase activity
EA665_RS17725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EA665_RS17740	COG0497	DNA recombination
EA665_RS17750	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EA665_RS17780	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EA665_RS17780	COG2169	Transcriptional regulator
EA665_RS17785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EA665_RS17835	COG0789	Transcriptional regulator
EA665_RS17845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EA665_RS17860	COG0326	Molecular chaperone. Has ATPase activity
EA665_RS17875	COG2056	Na+-H+ antiporter family
EA665_RS17975	COG0546	phosphoglycolate phosphatase activity
EA665_RS17980	COG1716	ATPase activity
EA665_RS18025	COG0181	hydroxymethylbilane synthase activity
EA665_RS18035	COG3275	phosphorelay sensor kinase activity
EA665_RS18055	COG1538	Outer membrane efflux protein
EA665_RS18060	COG0697	spore germination
EA665_RS18085	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EA665_RS18090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EA665_RS18095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EA665_RS18100	COG0772	Belongs to the SEDS family
EA665_RS18125	COG4974	Belongs to the 'phage' integrase family
EA665_RS18130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EA665_RS18140	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EA665_RS18150	COG2197	response regulator
EA665_RS18165	COG0793	Belongs to the peptidase S41A family
EA665_RS18170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EA665_RS18175	COG0795	lipopolysaccharide-transporting ATPase activity
EA665_RS18215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EA665_RS18215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EA665_RS18225	COG0004	ammonium transporteR
EA665_RS18230	COG0347	Belongs to the P(II) protein family
EA665_RS18240	COG0606	chelatase, subunit chli
EA665_RS18310	COG2132	Multicopper oxidase
EA665_RS18325	COG2205	protein histidine kinase activity
EA665_RS18330	COG2217	Heavy metal translocating P-type atpase
EA665_RS18375	COG0606	chelatase, subunit chli
EA665_RS18380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EA665_RS18385	COG0235	Class ii aldolase
EA665_RS18390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EA665_RS18405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EA665_RS18420	COG0318	PFAM AMP-dependent synthetase and ligase
EA665_RS18430	COG0477	Major facilitator Superfamily
EA665_RS18435	COG2860	membrane
EA665_RS18440	COG3012	SEC-C Motif Domain Protein
EA665_RS18445	COG1253	flavin adenine dinucleotide binding
EA665_RS18455	COG0477	Major facilitator Superfamily
EA665_RS18465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EA665_RS18500	COG0655	NAD(P)H dehydrogenase (quinone) activity
EA665_RS18510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EA665_RS18545	COG1309	transcriptional regulator
EA665_RS18580	COG0758	DNA mediated transformation
EA665_RS18590	COG0697	spore germination
EA665_RS18595	COG1309	transcriptional regulator
EA665_RS18610	COG0386	Belongs to the glutathione peroxidase family
EA665_RS18680	COG1121	(ABC) transporter
EA665_RS18685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EA665_RS18690	COG1280	lysine exporter protein (LysE YggA)
EA665_RS18695	COG2837	iron assimilation
EA665_RS18705	COG0281	malic enzyme
EA665_RS18750	COG0519	Catalyzes the synthesis of GMP from XMP
EA665_RS18750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EA665_RS18755	COG4399	Belongs to the UPF0754 family
EA665_RS18760	COG2259	Doxx family
EA665_RS18765	COG0586	Pfam SNARE associated Golgi protein
EA665_RS18780	COG1192	Involved in chromosome partitioning
EA665_RS18790	COG0271	Belongs to the BolA IbaG family
EA665_RS18810	COG4372	Transposase
EA665_RS18820	COG2963	transposase activity
EA665_RS18850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EA665_RS18850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EA665_RS18850	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EA665_RS18850	COG3321	synthase
EA665_RS18855	COG1960	acyl-CoA dehydrogenase activity
EA665_RS18865	COG2197	response regulator
EA665_RS18875	COG3916	Acyl-homoserine-lactone synthase
EA665_RS18880	COG0477	Major facilitator Superfamily
EA665_RS18885	COG1024	Enoyl-CoA hydratase
EA665_RS18890	COG1024	Enoyl-CoA hydratase
EA665_RS18895	COG1960	acyl-CoA dehydrogenase activity
EA665_RS18900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EA665_RS18920	COG1113	amino acid transport
EA665_RS18925	COG1113	amino acid transport
EA665_RS18930	COG0251	oxidation-reduction process
EA665_RS18970	COG0564	pseudouridine synthase activity
EA665_RS19040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EA665_RS19055	COG1802	Transcriptional regulator
EA665_RS19065	COG1448	Aminotransferase
EA665_RS19070	COG0277	FAD linked oxidase domain protein
EA665_RS19080	COG2186	Transcriptional regulator
EA665_RS19090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EA665_RS19095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EA665_RS19110	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EA665_RS19115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EA665_RS19120	COG1216	Glycosyl transferase, family 2
EA665_RS19140	COG0438	transferase activity, transferring glycosyl groups
EA665_RS19170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EA665_RS19200	COG0728	peptidoglycan biosynthetic process
EA665_RS19205	COG3023	N-Acetylmuramoyl-L-alanine amidase
EA665_RS19260	COG0546	phosphoglycolate phosphatase activity
EA665_RS19265	COG1028	Short-chain dehydrogenase reductase Sdr
EA665_RS19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EA665_RS19290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EA665_RS19295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EA665_RS19300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EA665_RS19305	COG1116	anion transmembrane transporter activity
EA665_RS19310	COG1309	transcriptional regulator
EA665_RS19315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EA665_RS19325	COG0196	riboflavin kinase activity
EA665_RS19330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EA665_RS19340	COG1047	Peptidyl-prolyl cis-trans
EA665_RS19380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EA665_RS19385	COG0657	acetylesterase activity
EA665_RS19435	COG2951	lytic endotransglycosylase activity
EA665_RS19440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EA665_RS19460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EA665_RS19470	COG0671	phosphoesterase, PA-phosphatase related
EA665_RS19475	COG0861	Integral membrane protein TerC family
EA665_RS19485	COG0754	glutathionylspermidine amidase activity
EA665_RS19495	COG0402	S-adenosylhomocysteine deaminase activity
EA665_RS19510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EA665_RS19515	COG1230	cation diffusion facilitator family transporter
EA665_RS19530	COG0706	membrane insertase activity
EA665_RS19655	COG2161	toxin-antitoxin pair type II binding
EA665_RS19775	COG4974	Belongs to the 'phage' integrase family
EA665_RS19790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII