locus-tag class description HWQ22_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HWQ22_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HWQ22_RS00030 ENOG4105DQR SNARE associated Golgi HWQ22_RS00035 ENOG4105C5H ABC transporter HWQ22_RS00040 ENOG4108821 RND type efflux pump HWQ22_RS00045 ENOG4108821 RND type efflux pump HWQ22_RS00050 ENOG4108821 RND type efflux pump HWQ22_RS00060 ENOG4105D74 hydrolase HWQ22_RS00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HWQ22_RS00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HWQ22_RS00110 ENOG4105C8J )-transporter HWQ22_RS00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HWQ22_RS00145 ENOG4108W5M transcriptional regulator HWQ22_RS00150 ENOG4105C2W permease HWQ22_RS00160 ENOG4108IG5 Transcriptional regulator HWQ22_RS00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HWQ22_RS00200 ENOG4105F27 Major Facilitator HWQ22_RS00205 ENOG4105CV8 reductase HWQ22_RS00210 ENOG4105HEI LysR family (Transcriptional regulator HWQ22_RS00230 ENOG4105DQ4 alcohol dehydrogenase HWQ22_RS00235 ENOG4108R3E Dna-3-methyladenine glycosylase i HWQ22_RS00250 ENOG4105CEN a g-specific adenine glycosylase HWQ22_RS00270 ENOG4108ZZ3 UPF0260 protein HWQ22_RS00280 ENOG4105D1H recombination factor protein RarA HWQ22_RS00285 ENOG4105S64 Formate nitrite transporter HWQ22_RS00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HWQ22_RS00310 ENOG4108RWI nicotinamidase HWQ22_RS00315 ENOG4105C09 Bile acid HWQ22_RS00320 ENOG4107QI1 Mate efflux family protein HWQ22_RS00325 ENOG4105EWC Purine nucleoside phosphorylase HWQ22_RS00345 ENOG4108RXX maleylacetoacetate isomerase HWQ22_RS00355 ENOG4105C85 amino acid HWQ22_RS00365 ENOG4105CKI cobalamin synthesis protein HWQ22_RS00375 ENOG4105CZE histidine utilization repressor HWQ22_RS00380 ENOG41090B9 response to stress HWQ22_RS00395 ENOG4105C85 amino acid HWQ22_RS00405 ENOG41088SP formiminoglutamate hydrolase HWQ22_RS00420 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HWQ22_RS00440 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HWQ22_RS00445 ENOG41082EK Restriction modification system DNA (Specificity HWQ22_RS00475 ENOG4105D70 Integrase catalytic subunit HWQ22_RS00535 ENOG4105F9F transposase HWQ22_RS00540 ENOG4105EUZ Beta-lactamase domain protein HWQ22_RS00550 ENOG4105F9F transposase HWQ22_RS00600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HWQ22_RS00610 ENOG4108ZAI phosphatidylglycerophosphatase a HWQ22_RS00615 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HWQ22_RS00630 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HWQ22_RS00665 ENOG4105KHC sulfurtransferase HWQ22_RS00695 ENOG4105BZU Histidine kinase HWQ22_RS00700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HWQ22_RS00715 ENOG4107QJQ Mate efflux family protein HWQ22_RS00720 ENOG4105CHM Aminotransferase HWQ22_RS00725 ENOG4106BRA Membrane HWQ22_RS00740 ENOG4105D9M gamma-glutamylcysteine synthetase HWQ22_RS00750 ENOG4105CS6 Rhs element vgr protein HWQ22_RS00755 ENOG4105K4H Nlp p60 protein HWQ22_RS00770 ENOG4105IPS esterase HWQ22_RS00775 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HWQ22_RS00780 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HWQ22_RS00785 ENOG4108Z2U ureidoglycolate hydrolase HWQ22_RS00795 ENOG41061H0 Monooxygenase HWQ22_RS00810 ENOG41084YZ Hydrolase HWQ22_RS00840 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HWQ22_RS00845 ENOG4105BZU Histidine kinase HWQ22_RS00860 ENOG4105KUZ arsenate reductase HWQ22_RS00865 ENOG4105CGK Exodeoxyribonuclease III HWQ22_RS00885 ENOG4105D7Z glutathione synthase HWQ22_RS00905 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HWQ22_RS00910 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HWQ22_RS00915 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HWQ22_RS00930 ENOG41063SB peptidase HWQ22_RS00935 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HWQ22_RS00940 ENOG4107QSN dihydrolipoamide acetyltransferase HWQ22_RS00955 ENOG4105E0K tonB-dependent siderophore receptor HWQ22_RS00970 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HWQ22_RS00985 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HWQ22_RS01005 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HWQ22_RS01010 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HWQ22_RS01020 ENOG4105D64 Mechanosensitive ion channel HWQ22_RS01030 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HWQ22_RS01035 ENOG4108W2Y isochorismatase HWQ22_RS01045 ENOG4105D5G Transposase HWQ22_RS01050 ENOG4105FBW Monooxygenase HWQ22_RS01055 ENOG4108UZX fmn reductase HWQ22_RS01070 ENOG4105BZU Histidine kinase HWQ22_RS01075 ENOG41062QD Membrane HWQ22_RS01080 ENOG4107QN1 sodium solute HWQ22_RS01090 ENOG4105C94 Transporter HWQ22_RS01100 ENOG4105BZU Histidine kinase HWQ22_RS01110 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HWQ22_RS01115 ENOG4108WUH Transcriptional regulator, TetR family HWQ22_RS01120 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HWQ22_RS01130 ENOG4105RA2 Membrane HWQ22_RS01135 ENOG4105DWF phosphomethylpyrimidine kinase HWQ22_RS01145 ENOG4107RDB Major Facilitator HWQ22_RS01150 ENOG4108UUM single-stranded DNA-binding protein HWQ22_RS01160 ENOG4108UMN azlc family HWQ22_RS01170 ENOG4105C85 amino acid HWQ22_RS01180 ENOG4108JPW Aminotransferase HWQ22_RS01185 ENOG4105C26 Dehydrogenase HWQ22_RS01195 ENOG4105CHJ isochorismatase hydrolase HWQ22_RS01200 ENOG4105EUB pirin domain protein HWQ22_RS01225 ENOG4105D94 Major Facilitator Superfamily HWQ22_RS01230 ENOG4106NZI LysR family Transcriptional regulator HWQ22_RS01250 ENOG4105CPC Aldo Keto reductase HWQ22_RS01255 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HWQ22_RS01280 ENOG4105KVH Transcriptional regulator HWQ22_RS01285 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HWQ22_RS01360 ENOG4105CUV Homoserine Kinase HWQ22_RS01375 ENOG41061CK Antibiotic biosynthesis monooxygenase HWQ22_RS01405 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HWQ22_RS01430 ENOG4108R6G acetyltransferase HWQ22_RS01435 ENOG4105CYC Transferase HWQ22_RS01445 ENOG4105E0F Histidine kinase HWQ22_RS01460 ENOG4105CHH sulfate transporter HWQ22_RS01465 ENOG4105PDP Short chain dehydrogenase HWQ22_RS01475 ENOG4105C5H ABC transporter HWQ22_RS01560 ENOG4108IQI permease HWQ22_RS01585 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HWQ22_RS01600 ENOG4105CJN penicillin-binding protein HWQ22_RS01605 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HWQ22_RS01610 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HWQ22_RS01625 ENOG4105DHI Methyltransferase HWQ22_RS01630 ENOG4108JQC penicillin-binding protein 1A HWQ22_RS01655 ENOG4105E4G Type IV pilus HWQ22_RS01675 ENOG4105CBC glutamate synthase HWQ22_RS01680 ENOG4105BZ8 glutamate synthase HWQ22_RS01690 ENOG4108V0P LemA family HWQ22_RS01695 ENOG4105HA9 of methanol dehydrogenase type HWQ22_RS01715 ENOG4108YSG O-Antigen polymerase HWQ22_RS01720 ENOG4108UQY Iron-storage protein HWQ22_RS01730 ENOG4105KME endoribonuclease L-psp HWQ22_RS01735 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HWQ22_RS01750 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HWQ22_RS01800 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HWQ22_RS01815 ENOG4107IFA Lipase (EC 3.1.1.3) HWQ22_RS01820 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HWQ22_RS01825 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HWQ22_RS01850 ENOG4108JQ1 Dehydrogenase HWQ22_RS01855 ENOG4105CQB FAD linked oxidase domain protein HWQ22_RS01865 ENOG4105VRH Antibiotic biosynthesis monooxygenase HWQ22_RS01870 ENOG4105NF4 modulator of drug activity HWQ22_RS01880 ENOG4107QF7 multi-drug HWQ22_RS01885 ENOG4105EM2 membrane HWQ22_RS01890 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HWQ22_RS01895 ENOG4105IPI Membrane HWQ22_RS01900 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HWQ22_RS01930 ENOG4108IQI permease HWQ22_RS01935 ENOG4105D82 Glutamate dehydrogenase HWQ22_RS01940 ENOG4105C8Y Acetylornithine aminotransferase HWQ22_RS01950 ENOG4105C26 Dehydrogenase HWQ22_RS02035 ENOG4105W87 Cbs domain HWQ22_RS02040 ENOG41067S9 phage shock protein C, PspC HWQ22_RS02050 ENOG4105CSU acyl-Coa dehydrogenase HWQ22_RS02065 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HWQ22_RS02080 ENOG4105ECY inositol monophosphatase HWQ22_RS02085 ENOG4105C1J atp-dependent rna helicase HWQ22_RS02095 ENOG4105DHJ ABC, transporter HWQ22_RS02100 ENOG4105CY3 ABC transporter, permease HWQ22_RS02110 ENOG4105E3I toluene tolerance HWQ22_RS02120 ENOG4105D7N magnesium and cobalt transport protein CorA HWQ22_RS02125 ENOG4108URH decarboxylase HWQ22_RS02135 ENOG4105MJ2 Competence protein HWQ22_RS02140 ENOG4105CB5 ATP-dependent DNA helicase recG HWQ22_RS02160 ENOG4105C29 acyl-CoA thioesterase HWQ22_RS02165 ENOG4105CK2 sodium dicarboxylate symporter HWQ22_RS02180 ENOG4105KPV Transcriptional regulator HWQ22_RS02190 ENOG4105D7A ATP-binding protein HWQ22_RS02200 ENOG41089BK Glutamine amido-transferase HWQ22_RS02310 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HWQ22_RS02350 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS02385 ENOG4105VKU nucleicacid-binding protein HWQ22_RS02390 ENOG4105DGW oligopeptidase A HWQ22_RS02395 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HWQ22_RS02440 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HWQ22_RS02445 ENOG4108K2B transcriptional regulator HWQ22_RS02455 ENOG4107S2Z UPF0761 membrane protein HWQ22_RS02460 ENOG4105CS1 NAD(P)H quinone oxidoreductase HWQ22_RS02490 ENOG4105C9A Phoh family HWQ22_RS02500 ENOG4105E4C Lytic transglycosylase catalytic HWQ22_RS02530 ENOG4105D6S protein involved in catabolism of external DNA HWQ22_RS02535 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HWQ22_RS02580 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS02585 ENOG4108RZE Tetr family transcriptional regulator HWQ22_RS02600 ENOG4107QX3 carboxylase HWQ22_RS02605 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS02625 ENOG4105KB2 stringent starvation protein b HWQ22_RS02630 ENOG4107MKT Stringent starvation protein a HWQ22_RS02635 ENOG4108UJD 30S ribosomal protein S9 HWQ22_RS02645 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HWQ22_RS02650 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HWQ22_RS02655 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HWQ22_RS02675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HWQ22_RS02685 ENOG4107RZC phospholipase d HWQ22_RS02695 ENOG4105UYK outer membrane protein a HWQ22_RS02710 ENOG4108HWY Beta-lactamase HWQ22_RS02720 ENOG4105F6A helicase HWQ22_RS02770 ENOG4107QN2 dihydrolipoyl dehydrogenase HWQ22_RS02785 ENOG4107U2T alpha beta HWQ22_RS02795 ENOG4105NAU thioesterase Superfamily protein HWQ22_RS02825 ENOG4105K9H YciI-like protein HWQ22_RS02835 ENOG4105DB7 PHP domain protein HWQ22_RS02840 ENOG4105FFC UPF0187 protein HWQ22_RS02850 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HWQ22_RS02855 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HWQ22_RS02860 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HWQ22_RS02865 ENOG4105VIE preprotein translocase, subunit YajC HWQ22_RS02895 ENOG4105BZU Histidine kinase HWQ22_RS02900 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HWQ22_RS02905 ENOG4105CM2 brancheD-chain amino acid aminotransferase HWQ22_RS02920 ENOG4107BJW polysaccharide deacetylase HWQ22_RS02930 ENOG4108PQP glycosyl transferase group 1 HWQ22_RS02970 ENOG4105UGU tonB-dependent Receptor HWQ22_RS02990 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HWQ22_RS02995 ENOG4108K3A Glutathione S-transferase HWQ22_RS03000 ENOG4108R4R Iron-regulated virulence regulatory protein HWQ22_RS03005 ENOG4105CSU acyl-Coa dehydrogenase HWQ22_RS03010 ENOG4105CSU acyl-Coa dehydrogenase HWQ22_RS03020 ENOG4105EB3 Histidine kinase HWQ22_RS03025 ENOG4105E3W Two component transcriptional regulator (Winged helix family HWQ22_RS03030 ENOG4105CNG UPF0061 protein HWQ22_RS03050 ENOG4108WBT adenosyltransferase HWQ22_RS03100 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HWQ22_RS03120 ENOG4105D3R alkyl hydroperoxide reductase HWQ22_RS03135 ENOG4105CSH Transporter HWQ22_RS03140 ENOG4108UT2 hemolysin iii HWQ22_RS03170 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS03175 ENOG4108R6W Transcriptional regulator, ARAC family HWQ22_RS03185 ENOG4105TW1 Carbohydrate-selective porin OprB HWQ22_RS03190 ENOG4105DZG Dehydrogenase HWQ22_RS03195 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HWQ22_RS03205 ENOG410814C multidrug resistance protein HWQ22_RS03215 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS03225 ENOG4108WHA ompa motb domain protein HWQ22_RS03235 ENOG4105E0Y RtcB Protein HWQ22_RS03240 ENOG4108IQI permease HWQ22_RS03250 ENOG4105C2W permease HWQ22_RS03255 ENOG4105CI3 gtp-binding protein typa HWQ22_RS03270 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HWQ22_RS03280 ENOG4108VX5 3-methyladenine DNA glycosylase HWQ22_RS03285 ENOG4105CHB tonB-dependent Receptor HWQ22_RS03300 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HWQ22_RS03305 ENOG4108N2Y auxin Efflux HWQ22_RS03315 ENOG4105T95 Thiol disulfide interChange protein HWQ22_RS03320 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HWQ22_RS03330 ENOG4105K78 MarR family Transcriptional regulator HWQ22_RS03335 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HWQ22_RS03340 ENOG4105KWI UPF0339 protein HWQ22_RS03365 ENOG4108UNF response regulator HWQ22_RS03370 ENOG4105M3Z response regulator HWQ22_RS03375 ENOG4108ZGA chew protein HWQ22_RS03380 ENOG4105C8Q Methyl-accepting chemotaxis HWQ22_RS03385 ENOG4105CBS Chea signal transduction histidine kinase HWQ22_RS03400 ENOG4107PEH Entericidin EcnA/B family HWQ22_RS03410 ENOG4105WD1 Membrane HWQ22_RS03415 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HWQ22_RS03465 ENOG4105EM2 membrane HWQ22_RS03470 ENOG4105C2C drug resistance transporter, Bcr CflA HWQ22_RS03490 ENOG4105BZG amino acid carrier protein HWQ22_RS03495 ENOG4105D78 K07001 NTE family protein HWQ22_RS03500 ENOG4105C7B Threonine dehydratase HWQ22_RS03545 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HWQ22_RS03555 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HWQ22_RS03565 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HWQ22_RS03570 ENOG4105VQ7 Rod shape-determining protein MreD HWQ22_RS03575 ENOG4108Z03 MAF-like protein HWQ22_RS03580 ENOG4105C03 ribonuclease HWQ22_RS03590 ENOG4105D8T Acyltransferase HWQ22_RS03600 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HWQ22_RS03610 ENOG4108X0B nad(p)h dehydrogenase (quinone) HWQ22_RS03635 ENOG4105CF7 AraC family transcriptional regulator HWQ22_RS03655 ENOG4105C85 amino acid HWQ22_RS03660 ENOG4105C7F AcnD-accessory protein PrpF HWQ22_RS03665 ENOG4105CTB Polyprenyl synthetase HWQ22_RS03670 ENOG4105MSB protein, conserved in bacteria HWQ22_RS03685 ENOG4105D78 K07001 NTE family protein HWQ22_RS03705 ENOG4105DIJ Phosphoethanolamine transferase HWQ22_RS03710 ENOG4105XJC Two component transcriptional regulator (Winged helix family HWQ22_RS03715 ENOG4105DHQ Histidine kinase HWQ22_RS03730 ENOG4108M0I Transcriptional regulator HWQ22_RS03750 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HWQ22_RS03770 ENOG4105K8R UPF0145 protein HWQ22_RS03775 ENOG4105K8R UPF0145 protein HWQ22_RS03780 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HWQ22_RS03785 ENOG4105BZS acriflavin resistance protein HWQ22_RS03790 ENOG4105C1P efflux transporter, rnd family, mfp subunit HWQ22_RS03795 ENOG410841Q phosphoesterase PA-phosphatase related protein HWQ22_RS03825 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HWQ22_RS03840 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HWQ22_RS03845 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HWQ22_RS03850 ENOG4105KVH Transcriptional regulator HWQ22_RS03860 ENOG4105CUB amino acid HWQ22_RS03875 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HWQ22_RS03880 ENOG41084BA UPF0250 protein HWQ22_RS03885 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HWQ22_RS03925 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HWQ22_RS03930 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HWQ22_RS03940 ENOG4105E33 succinate dehydrogenase HWQ22_RS03955 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HWQ22_RS03960 ENOG4105C7S Dehydrogenase HWQ22_RS03965 ENOG4107QN2 dihydrolipoyl dehydrogenase HWQ22_RS03975 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HWQ22_RS03985 ENOG4105CKW Inner membrane protein yedI HWQ22_RS03990 ENOG4105CGZ zinc metallopeptidase HWQ22_RS03995 ENOG4105EEQ Na H antiporter HWQ22_RS04045 ENOG4105PNM synthesis protein HWQ22_RS04060 ENOG41080TK Universal stress protein HWQ22_RS04075 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HWQ22_RS04080 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HWQ22_RS04095 ENOG4105HBR Rna-binding protein HWQ22_RS04105 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HWQ22_RS04110 ENOG4105EEI dihydropteroate synthase HWQ22_RS04160 ENOG4105CSH Transporter HWQ22_RS04165 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HWQ22_RS04170 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HWQ22_RS04185 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HWQ22_RS04195 ENOG4105F9F transposase HWQ22_RS04215 ENOG41080IJ Diacylglycerol kinase HWQ22_RS04225 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HWQ22_RS04230 ENOG4105BZS acriflavin resistance protein HWQ22_RS04245 ENOG4105E4C Lytic transglycosylase catalytic HWQ22_RS04265 ENOG4108RRZ Transcription elongation factor GreB HWQ22_RS04280 ENOG4105CEY Amp-dependent synthetase and ligase HWQ22_RS04320 ENOG4105BZW Glycerate kinase HWQ22_RS04325 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HWQ22_RS04330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HWQ22_RS04345 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HWQ22_RS04355 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HWQ22_RS04360 ENOG4105C85 amino acid HWQ22_RS04370 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HWQ22_RS04380 ENOG4105N14 lysine exporter protein LysE YggA HWQ22_RS04385 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HWQ22_RS04390 ENOG4105BZJ Electron transfer flavoprotein HWQ22_RS04395 ENOG4105C10 Electron transfer flavoprotein HWQ22_RS04400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HWQ22_RS04435 ENOG4107KET secretion protein, HlyD family HWQ22_RS04470 ENOG4105D60 lipoprotein releasing system transmembrane protein HWQ22_RS04475 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HWQ22_RS04480 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HWQ22_RS04490 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HWQ22_RS04495 ENOG4107R6F Alpha Beta Hydrolase Fold protein HWQ22_RS04500 ENOG4108V3E phosphoribosylglycinamide formyltransferase HWQ22_RS04510 ENOG4105C02 permease HWQ22_RS04560 ENOG4105KCK Peptidoglycan-associated lipoprotein HWQ22_RS04565 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HWQ22_RS04575 ENOG4105M8F Biopolymer transport protein exbD tolR HWQ22_RS04580 ENOG4105E02 MotA TolQ exbB proton channel HWQ22_RS04585 ENOG4107YD3 Thioesterase HWQ22_RS04590 ENOG4105CH2 amidohydrolase HWQ22_RS04610 ENOG4108ETH Formylglycinamide ribotide synthetase HWQ22_RS04615 ENOG4105C2C drug resistance transporter, Bcr CflA HWQ22_RS04625 ENOG4108UKI Enoyl-CoA hydratase HWQ22_RS04640 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HWQ22_RS04655 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HWQ22_RS04660 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HWQ22_RS04680 ENOG4107R11 Transcriptional regulator HWQ22_RS04685 ENOG4108IJ6 ABC transporter HWQ22_RS04695 ENOG4108I5D sulfate abc transporter HWQ22_RS04705 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HWQ22_RS04710 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HWQ22_RS04715 ENOG4105HHA aminodeoxychorismate lyase HWQ22_RS04730 ENOG4108IYU L-aspartate oxidase HWQ22_RS04735 ENOG4105C0H protease HWQ22_RS04750 ENOG4105C3F Signal peptidase i HWQ22_RS04765 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HWQ22_RS04775 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HWQ22_RS04780 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HWQ22_RS04785 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HWQ22_RS04790 ENOG4105EMU Dehydrogenase HWQ22_RS04830 ENOG4105BZU Histidine kinase HWQ22_RS04840 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HWQ22_RS04850 ENOG4105DTR rard protein HWQ22_RS04885 ENOG4107QS8 (LipO)protein HWQ22_RS04890 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HWQ22_RS04895 ENOG4105EA8 2-Nitropropane dioxygenase HWQ22_RS04925 ENOG4107R8N Glycosyl transferase, family 2 HWQ22_RS04940 ENOG4105CVP deoxyribo-dipyrimidine photolyase HWQ22_RS04945 ENOG4108YZY peptidylprolyl cis-trans isomerase HWQ22_RS04950 ENOG4105CEP NADH dehydrogenase HWQ22_RS04955 ENOG4105DZ1 carboxypeptidase HWQ22_RS04965 ENOG4105E9K Isocitrate dehydrogenase HWQ22_RS04970 ENOG4108R99 pseudouridine synthase HWQ22_RS04995 ENOG4105CBP Major Facilitator HWQ22_RS05000 ENOG4105EGI Transcriptional regulator HWQ22_RS05005 ENOG4108ETY sodium dicarboxylate symporter HWQ22_RS05010 ENOG4105JAB phenazine biosynthesis protein, phzf family HWQ22_RS05040 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HWQ22_RS05055 ENOG4105D3G Pseudouridine synthase HWQ22_RS05060 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HWQ22_RS05075 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HWQ22_RS05100 ENOG4108JPW Aminotransferase HWQ22_RS05105 ENOG4105DY8 decarboxylase HWQ22_RS05115 ENOG4105F7P transcriptional regulator AsnC family HWQ22_RS05120 ENOG4107RA9 decarboxylase HWQ22_RS05125 ENOG4105C85 amino acid HWQ22_RS05130 ENOG4105CVA phosphate HWQ22_RS05135 ENOG4105C8U phosphate abc transporter HWQ22_RS05145 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HWQ22_RS05150 ENOG4105ERU peptidase HWQ22_RS05160 ENOG4105D5G Transposase HWQ22_RS05170 ENOG4107QTF adenylosuccinate lyase HWQ22_RS05190 ENOG4108Z0R Transferase HWQ22_RS05195 ENOG4105DZ1 carboxypeptidase HWQ22_RS05215 ENOG4108K5P (LipO)protein HWQ22_RS05220 ENOG4105EJC lysr family transcriptional regulator HWQ22_RS05225 ENOG4105DAN ATP-dependent protease HWQ22_RS05240 ENOG4105DHU Bile acid HWQ22_RS05260 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HWQ22_RS05270 ENOG4105D22 carbon starvation protein HWQ22_RS05275 ENOG4105VCD cytoplasmic protein HWQ22_RS05305 ENOG4108K8K Transcriptional regulator HWQ22_RS05320 ENOG4105C26 Dehydrogenase HWQ22_RS05325 ENOG4105C85 amino acid HWQ22_RS05335 ENOG4105ETT transcriptional Regulator, LysR family HWQ22_RS05340 ENOG4105C94 Transporter HWQ22_RS05345 ENOG4105C94 Transporter HWQ22_RS05360 ENOG4107QZF nitrite reductase NADPH large subunit HWQ22_RS05365 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HWQ22_RS05395 ENOG41060M8 Pfam:PhdYeFM HWQ22_RS05400 ENOG4107QNK )-transporter HWQ22_RS05405 ENOG4107WEA mandelate racemase muconate lactonizing HWQ22_RS05415 ENOG4105J7D transcriptional regulator HWQ22_RS05435 ENOG4105C2I pirin domain protein HWQ22_RS05445 ENOG4105WWK YheO domain protein HWQ22_RS05460 ENOG4105CEY Amp-dependent synthetase and ligase HWQ22_RS05475 ENOG4108IPW abc transporter atp-binding protein HWQ22_RS05495 ENOG4105C0W non-ribosomal peptide synthetase HWQ22_RS05500 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HWQ22_RS05505 ENOG4105WQI isochorismatase HWQ22_RS05520 ENOG4105BZ1 (ABC) transporter HWQ22_RS05540 ENOG4105E4F Isochorismate synthase HWQ22_RS05555 ENOG4105NX3 Membrane HWQ22_RS05580 ENOG4105EUJ GTP cyclohydrolase i HWQ22_RS05590 ENOG4105C7W Xanthine dehydrogenase HWQ22_RS05620 ENOG4105CD8 aminopeptidase N HWQ22_RS05625 ENOG4105DDQ anthranilate synthase HWQ22_RS05635 ENOG4105DUX Transporter HWQ22_RS05650 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HWQ22_RS05685 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HWQ22_RS05690 ENOG4107QNR UPF0135 protein HWQ22_RS05695 ENOG4105C0H protease HWQ22_RS05705 ENOG4105C6K Malic enzyme HWQ22_RS05710 ENOG4105BZU Histidine kinase HWQ22_RS05715 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HWQ22_RS05720 ENOG4105SYT Methylenetetrahydrofolate reductase HWQ22_RS05725 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HWQ22_RS05740 ENOG4107QPN acyl-Coa dehydrogenase HWQ22_RS05745 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HWQ22_RS05750 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HWQ22_RS05760 ENOG4107RNU major facilitator superfamily MFS_1 HWQ22_RS05770 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HWQ22_RS05775 ENOG4105CE9 30S ribosomal protein S2 HWQ22_RS05815 ENOG4105CVE Lytic murein transglycosylase HWQ22_RS05820 ENOG4105CNI cell division protein FtsW HWQ22_RS05835 ENOG4105E3A (ABC) transporter HWQ22_RS05840 ENOG4105DA5 (ABC) transporter HWQ22_RS05875 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HWQ22_RS05885 ENOG4105ENT Efflux transporter rnd family, mfp subunit HWQ22_RS05895 ENOG4105E89 ABC transporter HWQ22_RS05900 ENOG4105DSP amino acid AbC transporter HWQ22_RS05905 ENOG4106YG3 ABC transporter HWQ22_RS05910 ENOG4108JEH abc transporter atp-binding protein HWQ22_RS05920 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HWQ22_RS05925 ENOG4105CFP Peptidase U32 HWQ22_RS05930 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HWQ22_RS05935 ENOG4105JAB phenazine biosynthesis protein, phzf family HWQ22_RS05940 ENOG4105DP0 ferredoxin-NADP reductase HWQ22_RS05945 ENOG4108R96 Methyltransferase, YaeB family HWQ22_RS05955 ENOG4107QHF type ii secretion system protein e HWQ22_RS05965 ENOG4105XJC Two component transcriptional regulator (Winged helix family HWQ22_RS05970 ENOG4105DHQ Histidine kinase HWQ22_RS05980 ENOG4105M6F mutator MutT protein HWQ22_RS05990 ENOG4105BZ4 penicillin-binding protein HWQ22_RS05995 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HWQ22_RS06000 ENOG4105VUT cytoplasmic protein HWQ22_RS06005 ENOG4107QYG anthranilate phosphoribosyltransferase HWQ22_RS06010 ENOG4105CK2 sodium dicarboxylate symporter HWQ22_RS06015 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS06020 ENOG4105NIV Esterase HWQ22_RS06025 ENOG4105CQC Prephenate dehydratase HWQ22_RS06030 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HWQ22_RS06040 ENOG4105CIN aminoacyl-histidine dipeptidase HWQ22_RS06045 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HWQ22_RS06075 ENOG4105M08 Membrane HWQ22_RS06080 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HWQ22_RS06090 ENOG4105VEQ Cold shock protein HWQ22_RS06095 ENOG4105C1J atp-dependent rna helicase HWQ22_RS06105 ENOG41069NU Nitroreductase HWQ22_RS06140 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HWQ22_RS06155 ENOG4105C5I Dehydrogenase HWQ22_RS06160 ENOG4105ERG peptidase m48, ste24p HWQ22_RS06165 ENOG4105KTH gatB Yqey HWQ22_RS06195 ENOG4105D9P serine threonine protein kinase HWQ22_RS06220 ENOG4105EVZ LysR family transcriptional regulator HWQ22_RS06225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HWQ22_RS06230 ENOG4105C26 Dehydrogenase HWQ22_RS06265 ENOG4105H4F exported protein HWQ22_RS06295 ENOG4105D6U Sodium Glutamate Symporter HWQ22_RS06305 ENOG4105JXH GntR family transcriptional regulator HWQ22_RS06320 ENOG4105F9F transposase HWQ22_RS06360 ENOG4105CSH Transporter HWQ22_RS06380 ENOG4105CEB Aspartate aminotransferase HWQ22_RS06395 ENOG4105F1S paraquat-inducible protein a HWQ22_RS06400 ENOG4105DY2 Paraquat-inducible protein b HWQ22_RS06415 ENOG4108BUD transposase HWQ22_RS06435 ENOG4108BUD transposase HWQ22_RS06485 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HWQ22_RS06540 ENOG4108BUD transposase HWQ22_RS06555 ENOG4105CK2 sodium dicarboxylate symporter HWQ22_RS06565 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HWQ22_RS06570 ENOG4108UMI ABC transporter, permease HWQ22_RS06575 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HWQ22_RS06585 ENOG4105C12 Phosphoribosylglycinamide synthetase HWQ22_RS06590 ENOG4105DC1 bifunctional purine biosynthesis protein purh HWQ22_RS06595 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HWQ22_RS06645 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HWQ22_RS06650 ENOG4105CDU Replicative dna helicase HWQ22_RS06675 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HWQ22_RS06680 ENOG4105CCU oxidase (Subunit III) HWQ22_RS06685 ENOG4105BZ9 Cytochrome C oxidase, subunit I HWQ22_RS06690 ENOG4105E2S oxidase) subunit II HWQ22_RS06715 ENOG4107BJW polysaccharide deacetylase HWQ22_RS06720 ENOG4105CND Glycosyl transferase, family 2 HWQ22_RS06735 ENOG4105DEN Luciferase family HWQ22_RS06750 ENOG4105CC0 LysR family Transcriptional regulator HWQ22_RS06765 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HWQ22_RS06770 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HWQ22_RS06775 ENOG4105GVF (ABC) transporter HWQ22_RS06790 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS06800 ENOG4108MEJ flavin reductase domain protein HWQ22_RS06805 ENOG4105D06 uba thif-type nad fad binding protein HWQ22_RS06825 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HWQ22_RS06830 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HWQ22_RS06840 ENOG4105C08 Histidine kinase HWQ22_RS06845 ENOG4105EEX Two component transcriptional regulator (Winged helix family HWQ22_RS06850 ENOG4105CFQ glutamine synthetase HWQ22_RS06865 ENOG4107S74 Lysophospholipid transporter LplT HWQ22_RS06870 ENOG4105CFU surface antigen HWQ22_RS06885 ENOG4107QIJ Aconitate hydratase 2 HWQ22_RS06895 ENOG4105EYW Ion transport protein HWQ22_RS06900 ENOG4105F27 Major Facilitator HWQ22_RS06915 ENOG4105DZ2 Transcriptional regulator HWQ22_RS06950 ENOG4105K8N protein family UPF0079, ATPase HWQ22_RS06955 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HWQ22_RS06965 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HWQ22_RS06970 ENOG4108TZV Membrane HWQ22_RS06975 ENOG4108RCM Nitroreductase HWQ22_RS06985 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HWQ22_RS06995 ENOG4105CX6 glutaminyL-tRNA synthetase HWQ22_RS07000 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HWQ22_RS07005 ENOG4107FQ9 ethanolamine ammonia-lyase HWQ22_RS07010 ENOG4105CPD ethanolamine ammonia-lyase HWQ22_RS07015 ENOG4107R55 ethanolamine transporter HWQ22_RS07025 ENOG4107RR1 TRANSCRIPTIONal HWQ22_RS07035 ENOG4105C0A alcohol dehydrogenase HWQ22_RS07040 ENOG4107QUV Domain protein HWQ22_RS07050 ENOG4105F4I Transcriptional regulator HWQ22_RS07070 ENOG4105CD8 aminopeptidase N HWQ22_RS07100 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HWQ22_RS07105 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS07115 ENOG4105R8C Transcriptional regulator HWQ22_RS07125 ENOG4105CUY Mechanosensitive ion channel HWQ22_RS07165 ENOG4105CNM Receptor HWQ22_RS07185 ENOG4105C5H ABC transporter HWQ22_RS07190 ENOG41081QV Universal stress protein HWQ22_RS07215 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HWQ22_RS07225 ENOG4105DKK Benzoate HWQ22_RS07230 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS07235 ENOG4108NIW Leucine export protein LeuE HWQ22_RS07245 ENOG4105C5Q Transcriptional regulator HWQ22_RS07255 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS07260 ENOG4105CHR reductase HWQ22_RS07285 ENOG4107QMP dna polymerase iii subunits gamma and tau HWQ22_RS07290 ENOG4105HSS phospholipase C HWQ22_RS07300 ENOG4105C0A alcohol dehydrogenase HWQ22_RS07330 ENOG4105CBC glutamate synthase HWQ22_RS07350 ENOG4105D8G Major Facilitator superfamily HWQ22_RS07360 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HWQ22_RS07365 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HWQ22_RS07390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HWQ22_RS07400 ENOG4107QZF nitrite reductase NADPH large subunit HWQ22_RS07405 ENOG4108IFG nitrite reductase, (NAD(P)H) HWQ22_RS07425 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HWQ22_RS07440 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HWQ22_RS07445 ENOG4105CVM Molybdenum cofactor synthesis domain protein HWQ22_RS07455 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HWQ22_RS07460 ENOG4105T38 integral membrane protein HWQ22_RS07480 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HWQ22_RS07485 ENOG4105CMR udp-glucose 4-epimerase HWQ22_RS07540 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HWQ22_RS07545 ENOG4105CUX Signal transduction histidine kinase HWQ22_RS07565 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HWQ22_RS07570 ENOG4105KNE Phosphatidate cytidylyltransferase HWQ22_RS07580 ENOG4105DZP Membrane-associated zinc metalloprotease HWQ22_RS07605 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HWQ22_RS07620 ENOG4105Y3E Modulates RecA activity (By similarity) HWQ22_RS07630 ENOG4105VEJ Heat shock protein HWQ22_RS07635 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HWQ22_RS07660 ENOG4105F7P transcriptional regulator AsnC family HWQ22_RS07670 ENOG4105C85 amino acid HWQ22_RS07685 ENOG4105CHH sulfate transporter HWQ22_RS07690 ENOG4108RAV Conserved protein HWQ22_RS07695 ENOG4105D8V Glucose sorbosone dehydrogenase HWQ22_RS07705 ENOG4105BZU Histidine kinase HWQ22_RS07725 ENOG4105DM4 PTS System HWQ22_RS07730 ENOG4105DE4 1-phosphofructokinase HWQ22_RS07735 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HWQ22_RS07760 ENOG4105CWM branched-chain amino acid transport system II carrier protein HWQ22_RS07765 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HWQ22_RS07770 ENOG4105CC0 LysR family Transcriptional regulator HWQ22_RS07780 ENOG4105M2J Glutaredoxin HWQ22_RS07785 ENOG4105C8Y Acetylornithine aminotransferase HWQ22_RS07790 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HWQ22_RS07815 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HWQ22_RS07825 ENOG41068P6 UPF0319 protein HWQ22_RS07845 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HWQ22_RS07850 ENOG4105C4M (Ubiquinol oxidase) subunit I HWQ22_RS07865 ENOG4105PV3 Inner membrane protein yqiJ HWQ22_RS07880 ENOG4105E0K tonB-dependent siderophore receptor HWQ22_RS07890 ENOG4105HDD phospholipase HWQ22_RS07895 ENOG4105CZN Potassium uptake protein HWQ22_RS07905 ENOG4105C7B Threonine dehydratase HWQ22_RS07935 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HWQ22_RS07940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HWQ22_RS07950 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HWQ22_RS07965 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HWQ22_RS08010 ENOG4107VMU Membrane HWQ22_RS08015 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HWQ22_RS08025 ENOG4107QP7 CoA-transferase subunit A HWQ22_RS08030 ENOG4107QNJ CoA-transferase subunit B HWQ22_RS08035 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS08040 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HWQ22_RS08045 ENOG4105F2Z 3-oxoadipate enol-lactonase HWQ22_RS08050 ENOG4105D2S major facilitator superfamily HWQ22_RS08055 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HWQ22_RS08060 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HWQ22_RS08065 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HWQ22_RS08070 ENOG4105FF2 Type I DHQase HWQ22_RS08075 ENOG4106JPM 3-dehydroshikimate dehydratase HWQ22_RS08080 ENOG4105TW1 Carbohydrate-selective porin OprB HWQ22_RS08085 ENOG4105DZG Dehydrogenase HWQ22_RS08095 ENOG4105MD1 YeeE YedE family protein HWQ22_RS08110 ENOG4107HP6 Transcriptional regulator HWQ22_RS08115 ENOG4108PTX LysR family Transcriptional regulator HWQ22_RS08120 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS08145 ENOG4105DNH Major Facilitator HWQ22_RS08155 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HWQ22_RS08175 ENOG4105FUY alpha subunit HWQ22_RS08185 ENOG4105CHR reductase HWQ22_RS08205 ENOG4105F11 amine oxidase HWQ22_RS08215 ENOG4105C26 Dehydrogenase HWQ22_RS08225 ENOG4105F2Z 3-oxoadipate enol-lactonase HWQ22_RS08230 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS08235 ENOG4107QNJ CoA-transferase subunit B HWQ22_RS08240 ENOG4107QP7 CoA-transferase subunit A HWQ22_RS08250 ENOG4105NN7 muconolactone delta-isomerase HWQ22_RS08255 ENOG4105DTQ mandelate racemase muconate lactonizing HWQ22_RS08260 ENOG4108KB2 LysR family Transcriptional regulator HWQ22_RS08270 ENOG4107EJG GntR family transcriptional regulator HWQ22_RS08290 ENOG4105CZJ Aldehyde dehydrogenase HWQ22_RS08310 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS08315 ENOG4105CHR reductase HWQ22_RS08320 ENOG4108JU7 Transcriptional regulator HWQ22_RS08330 ENOG41062QD Membrane HWQ22_RS08345 ENOG4107RGH Aldehyde dehydrogenase HWQ22_RS08360 ENOG4105CH6 catalase HWQ22_RS08380 ENOG4105K56 Transcriptional regulator HWQ22_RS08385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HWQ22_RS08395 ENOG4105NAE bifunctional deaminase-reductase domain protein HWQ22_RS08425 ENOG4107Z3H Transcriptional regulator, TetR family HWQ22_RS08435 ENOG4105CHJ isochorismatase hydrolase HWQ22_RS08440 ENOG4105EJC lysr family transcriptional regulator HWQ22_RS08445 ENOG4105D8V Glucose sorbosone dehydrogenase HWQ22_RS08450 ENOG4105CKD glutathione-regulated potassium-efflux system protein HWQ22_RS08460 ENOG4105CH2 amidohydrolase HWQ22_RS08470 ENOG4105D5K Hemolysin activator protein HWQ22_RS08475 ENOG4105CKT filamentous hemagglutinin HWQ22_RS08520 ENOG4106P55 Transcriptional regulator HWQ22_RS08550 ENOG4105JSC dimethylmenaquinone methyltransferase HWQ22_RS08570 ENOG4105CW7 secretion protein, HlyD family HWQ22_RS08585 ENOG4105CZJ Aldehyde dehydrogenase HWQ22_RS08600 ENOG4105DDW LysR family Transcriptional regulator HWQ22_RS08605 ENOG4105EXW epimerase dehydratase HWQ22_RS08615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HWQ22_RS08620 ENOG4105CF7 AraC family transcriptional regulator HWQ22_RS08635 ENOG4105DQ4 alcohol dehydrogenase HWQ22_RS08645 ENOG4105EHG Permease protein HWQ22_RS08650 ENOG4105E0A ABC, transporter HWQ22_RS08670 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HWQ22_RS08745 ENOG4108UAJ Transcriptional regulator HWQ22_RS08785 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HWQ22_RS08835 ENOG4108BAS reductase HWQ22_RS08850 ENOG4108R6W Transcriptional regulator, ARAC family HWQ22_RS08855 ENOG4108821 RND type efflux pump HWQ22_RS08860 ENOG4105E0F Histidine kinase HWQ22_RS08865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HWQ22_RS08870 ENOG4105C1P efflux transporter, rnd family, mfp subunit HWQ22_RS08875 ENOG4105BZS acriflavin resistance protein HWQ22_RS08880 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HWQ22_RS08890 ENOG4105CT3 Monooxygenase HWQ22_RS08910 ENOG4105CJP fad dependent oxidoreductase HWQ22_RS08930 ENOG4105X0I Fimbrial HWQ22_RS08985 ENOG4107RZC phospholipase d HWQ22_RS09005 ENOG4108IGT Dipeptidase HWQ22_RS09040 ENOG4107T31 5'-nucleotidase HWQ22_RS09050 ENOG4105WQI isochorismatase HWQ22_RS09055 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HWQ22_RS09060 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HWQ22_RS09065 ENOG4105E0C molybdate abc transporter HWQ22_RS09070 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HWQ22_RS09075 ENOG4105F4R Transcriptional regulator mode HWQ22_RS09080 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HWQ22_RS09085 ENOG4108YS2 small subunit HWQ22_RS09090 ENOG4105F57 Anthranilate dioxygenase reductase HWQ22_RS09115 ENOG4105CHR reductase HWQ22_RS09130 ENOG4105CF7 AraC family transcriptional regulator HWQ22_RS09140 ENOG4105DTD Dehydrogenase HWQ22_RS09145 ENOG4105CY2 Citrate transporter HWQ22_RS09155 ENOG4108M0I Transcriptional regulator HWQ22_RS09170 ENOG4107QNJ CoA-transferase subunit B HWQ22_RS09175 ENOG4105CRW Short chain fatty acid transporter HWQ22_RS09180 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS09190 ENOG4107YNJ LysR family Transcriptional regulator HWQ22_RS09205 ENOG4108IJ0 Aspartate ammonia-lyase HWQ22_RS09215 ENOG4105CSH Transporter HWQ22_RS09235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HWQ22_RS09240 ENOG4106FTQ Taurine ABC transporter, periplasmic HWQ22_RS09265 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HWQ22_RS09270 ENOG4105KVH Transcriptional regulator HWQ22_RS09275 ENOG4105UEI Transcriptional Regulator AraC Family HWQ22_RS09290 ENOG4108VCT Sulfite exporter TauE/SafE HWQ22_RS09300 ENOG4107QPB Beta-lactamase domain protein HWQ22_RS09310 ENOG4105FFC UPF0187 protein HWQ22_RS09320 ENOG4105CHR reductase HWQ22_RS09335 ENOG4105CPP Dehydrogenase, E1 component HWQ22_RS09340 ENOG4107R0V Pyruvate dehydrogenase HWQ22_RS09345 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HWQ22_RS09360 ENOG4105BZU Histidine kinase HWQ22_RS09370 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HWQ22_RS09375 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HWQ22_RS09420 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HWQ22_RS09435 ENOG4105C28 cystathionine HWQ22_RS09445 ENOG4105F2W methyltransferase HWQ22_RS09475 ENOG4105K59 histidine triad (HIT) protein HWQ22_RS09500 ENOG4107QWP ABC-2 type transporter HWQ22_RS09505 ENOG4107QWP ABC-2 type transporter HWQ22_RS09510 ENOG4105CJ1 ABC, transporter HWQ22_RS09525 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HWQ22_RS09530 ENOG4105CNM Receptor HWQ22_RS09550 ENOG4107TSN permease HWQ22_RS09555 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HWQ22_RS09575 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HWQ22_RS09580 ENOG4108YZT Adenosylcobinamide kinase HWQ22_RS09590 ENOG4107VXZ Hydrolase HWQ22_RS09630 ENOG4105DJU Siderophore biosynthesis protein HWQ22_RS09635 ENOG4105DUU IucA IucC family protein HWQ22_RS09655 ENOG4108Z66 YbaK ebsC protein HWQ22_RS09670 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS09675 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS09680 ENOG4105EEF Alkane 1-monooxygenase HWQ22_RS09685 ENOG4105E7U AraC family transcriptional regulator HWQ22_RS09690 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HWQ22_RS09695 ENOG4105K70 DNA-binding protein HWQ22_RS09710 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HWQ22_RS09720 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HWQ22_RS09725 ENOG4108Z4V iron-sulfur cluster assembly HWQ22_RS09740 ENOG4108ZIT Ferredoxin, 2FE-2S HWQ22_RS09745 ENOG4105F8J Adenylate Guanylate cyclase HWQ22_RS09755 ENOG4108JA2 transcriptioN-repair coupling factor HWQ22_RS09775 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HWQ22_RS09780 ENOG4105K4T epimerase HWQ22_RS09795 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HWQ22_RS09815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HWQ22_RS09825 ENOG4105DGW oligopeptidase A HWQ22_RS09865 ENOG4105SG9 biopolymer transport protein, ExbD HWQ22_RS09875 ENOG4107QP3 malate synthase g HWQ22_RS09880 ENOG4105D6Z AFG1 family ATPase HWQ22_RS09890 ENOG4107RN6 Monooxygenase HWQ22_RS09910 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HWQ22_RS09915 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HWQ22_RS09930 ENOG4108Z6B deaminase HWQ22_RS09950 ENOG4108RTD type II secretion system protein K HWQ22_RS09975 ENOG4105F8V Hydrolase, tatD family HWQ22_RS09985 ENOG4107QRG dna polymerase iii HWQ22_RS09995 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HWQ22_RS10000 ENOG4105BZ1 (ABC) transporter HWQ22_RS10015 ENOG4105FA0 parb-like partition protein HWQ22_RS10020 ENOG4107QJE Chromosome Partitioning Protein HWQ22_RS10030 ENOG4108S0S Nucleotidyl transferase HWQ22_RS10035 ENOG4105EHM Aminoglycoside phosphotransferase HWQ22_RS10040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HWQ22_RS10045 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HWQ22_RS10050 ENOG4105D2N Aldolase HWQ22_RS10070 ENOG4108UHJ MAF-like protein HWQ22_RS10075 ENOG4105EZE Cupin 4 family protein HWQ22_RS10085 ENOG41080HT Transcriptional regulator, arsr family HWQ22_RS10100 ENOG4105XPP Protein of unknown function (DUF1275) HWQ22_RS10105 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HWQ22_RS10110 ENOG4105BZ1 (ABC) transporter HWQ22_RS10120 ENOG4108ZX5 transcriptional regulator HWQ22_RS10130 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HWQ22_RS10135 ENOG4105CK7 Sodium proline symporter HWQ22_RS10140 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS10145 ENOG4105C26 Dehydrogenase HWQ22_RS10150 ENOG4105YGK Pfam:UPF0157 HWQ22_RS10165 ENOG4108T58 Mg2 transport protein CorA HWQ22_RS10175 ENOG4108YYC ycei family HWQ22_RS10185 ENOG4105CV1 Transketolase (EC 2.2.1.1) HWQ22_RS10210 ENOG4108HWY Beta-lactamase HWQ22_RS10230 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HWQ22_RS10235 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HWQ22_RS10255 ENOG4105X0I Fimbrial HWQ22_RS10260 ENOG4105GQR Chaperone HWQ22_RS10285 ENOG4108IPJ Membrane HWQ22_RS10295 ENOG4105ETS cytosine purines uracil thiamine allantoin HWQ22_RS10305 ENOG4105CC0 LysR family Transcriptional regulator HWQ22_RS10325 ENOG41067SE Tetr family transcriptional regulator HWQ22_RS10340 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS10350 ENOG4105CDA abc transporter atp-binding protein HWQ22_RS10355 ENOG4105DRP amino acid AbC transporter HWQ22_RS10360 ENOG4105EAD ABC transporter HWQ22_RS10375 ENOG4107T8P acyl-Coa dehydrogenase HWQ22_RS10390 ENOG4105D01 (LipO)protein HWQ22_RS10395 ENOG4105D01 (LipO)protein HWQ22_RS10400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HWQ22_RS10405 ENOG4108UMI ABC transporter, permease HWQ22_RS10410 ENOG4105C3G gtp-binding protein HWQ22_RS10435 ENOG4108UMN azlc family HWQ22_RS10440 ENOG4105ZED uncharacterized protein ygaH HWQ22_RS10470 ENOG4105E7U AraC family transcriptional regulator HWQ22_RS10475 ENOG4108V06 Glutathione peroxidase HWQ22_RS10485 ENOG4105CHM Aminotransferase HWQ22_RS10500 ENOG4105C0B DNA polymerase III (alpha subunit) HWQ22_RS10525 ENOG4108JU3 Alkyl hydroperoxide reductase HWQ22_RS10540 ENOG4108KB2 LysR family Transcriptional regulator HWQ22_RS10545 ENOG4105D6J arsenicaL-resistance protein HWQ22_RS10550 ENOG41082YX Transcriptional regulator, arsr family HWQ22_RS10565 ENOG4105CPN adenine deaminase HWQ22_RS10575 ENOG4105CBN LysR family transcriptional regulator HWQ22_RS10585 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HWQ22_RS10600 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HWQ22_RS10605 ENOG4108IY8 ABC, transporter HWQ22_RS10610 ENOG4106FTQ Taurine ABC transporter, periplasmic HWQ22_RS10625 ENOG4105C54 Major Facilitator superfamily HWQ22_RS10645 ENOG4105C4M (Ubiquinol oxidase) subunit I HWQ22_RS10650 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HWQ22_RS10660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HWQ22_RS10665 ENOG4108K70 Transcriptional regulator HWQ22_RS10680 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HWQ22_RS10685 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HWQ22_RS10700 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HWQ22_RS10705 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HWQ22_RS10715 ENOG4105DXI Major Facilitator superfamily HWQ22_RS10735 ENOG41067MG lrgb family HWQ22_RS10740 ENOG4105VAW lrga family HWQ22_RS10745 ENOG4105CMU LysR family (Transcriptional regulator HWQ22_RS10750 ENOG4108SHQ Glutathione S-transferase HWQ22_RS10755 ENOG4105CYM Glutathione S-transferase HWQ22_RS10760 ENOG4105CBN LysR family transcriptional regulator HWQ22_RS10765 ENOG4105CHR reductase HWQ22_RS10775 ENOG4105D7W serine acetyltransferase HWQ22_RS10780 ENOG4105ESN nucleotide-binding protein HWQ22_RS10785 ENOG4105C9B Cysteine desulfurase HWQ22_RS10795 ENOG4105CCF Lysine exporter protein (Lyse ygga) HWQ22_RS10800 ENOG4105EXG Transcriptional regulator HWQ22_RS10810 ENOG4105CT1 (ABC) transporter HWQ22_RS10815 ENOG4107RP9 extracellular solute-binding protein, family 3 HWQ22_RS10820 ENOG4105CDA abc transporter atp-binding protein HWQ22_RS10825 ENOG4108HW4 amino acid AbC transporter HWQ22_RS10830 ENOG4105EAD ABC transporter HWQ22_RS10845 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HWQ22_RS10850 ENOG4105BZU Histidine kinase HWQ22_RS10860 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS10870 ENOG4105KT5 UmuD protein HWQ22_RS10890 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HWQ22_RS10940 ENOG4105HEI LysR family (Transcriptional regulator HWQ22_RS10960 ENOG4105CEY Amp-dependent synthetase and ligase HWQ22_RS10965 ENOG4105R8C Transcriptional regulator HWQ22_RS10970 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS10975 ENOG4107QX3 carboxylase HWQ22_RS10980 ENOG4105E39 Enoyl-CoA hydratase HWQ22_RS10995 ENOG4105CC0 LysR family Transcriptional regulator HWQ22_RS11010 ENOG4105CSU acyl-Coa dehydrogenase HWQ22_RS11030 ENOG4107QNJ CoA-transferase subunit B HWQ22_RS11035 ENOG4107QP7 CoA-transferase subunit A HWQ22_RS11040 ENOG4107RGD Major Facilitator superfamily HWQ22_RS11045 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS11050 ENOG4105E39 Enoyl-CoA hydratase HWQ22_RS11055 ENOG4105CHR reductase HWQ22_RS11060 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HWQ22_RS11065 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS11075 ENOG4105EQ0 Major Facilitator superfamily HWQ22_RS11080 ENOG4105EA8 2-Nitropropane dioxygenase HWQ22_RS11085 ENOG4108UKI Enoyl-CoA hydratase HWQ22_RS11100 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS11105 ENOG4107RGD Major Facilitator superfamily HWQ22_RS11110 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HWQ22_RS11115 ENOG4107STF Involved in phosphonate degradation (By similarity) HWQ22_RS11125 ENOG4107RCV ABC transporter, permease HWQ22_RS11130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HWQ22_RS11135 ENOG4105C4Y ABC transporter HWQ22_RS11145 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HWQ22_RS11150 ENOG4107HP6 Transcriptional regulator HWQ22_RS11160 ENOG4105HEI LysR family (Transcriptional regulator HWQ22_RS11165 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HWQ22_RS11170 ENOG4105C26 Dehydrogenase HWQ22_RS11180 ENOG4105ETS cytosine purines uracil thiamine allantoin HWQ22_RS11190 ENOG4105C26 Dehydrogenase HWQ22_RS11195 ENOG4108M8W Monooxygenase HWQ22_RS11200 ENOG4105MXW flavin reductase domain protein, FMN-binding HWQ22_RS11205 ENOG4108MXF Alpha Beta Hydrolase HWQ22_RS11225 ENOG4105CPW cytochrome b561 HWQ22_RS11230 ENOG4107VGR Catalase HWQ22_RS11265 ENOG4107YAU phenylacetic acid degradation protein HWQ22_RS11275 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HWQ22_RS11280 ENOG4105DZS Phenylacetate-CoA ligase HWQ22_RS11285 ENOG4105CHU acetyl-coa acetyltransferase HWQ22_RS11290 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HWQ22_RS11295 ENOG4108UKI Enoyl-CoA hydratase HWQ22_RS11300 ENOG4105E39 Enoyl-CoA hydratase HWQ22_RS11305 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HWQ22_RS11310 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HWQ22_RS11315 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HWQ22_RS11320 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HWQ22_RS11325 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HWQ22_RS11330 ENOG4105DXM phenylacetic acid degradation protein HWQ22_RS11335 ENOG4105EJQ L-serine dehydratase HWQ22_RS11340 ENOG4107QTZ amino acid HWQ22_RS11345 ENOG4105CZJ Aldehyde dehydrogenase HWQ22_RS11370 ENOG4105MWK D-amino acid dehydrogenase, small subunit HWQ22_RS11390 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HWQ22_RS11400 ENOG4108Z4X TRANSCRIPTIONal HWQ22_RS11415 ENOG4105WPN DNA integration recombination invertion protein HWQ22_RS11430 ENOG4105DJ2 Major Facilitator Superfamily HWQ22_RS11435 ENOG4107Y2X deaminase HWQ22_RS11445 ENOG4105EMY transcriptional regulator HWQ22_RS11475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HWQ22_RS11555 ENOG4108HW3 (ABC) transporter HWQ22_RS11565 ENOG4105MRR Transcriptional regulator (By similarity) HWQ22_RS11585 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HWQ22_RS11590 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HWQ22_RS11605 ENOG4105E2A Dehydrogenase HWQ22_RS11615 ENOG4105R8C Transcriptional regulator HWQ22_RS11635 ENOG4107R4J Chloride channel HWQ22_RS11640 ENOG4108JIK carboxylase HWQ22_RS11660 ENOG4105C5A transporter HWQ22_RS11665 ENOG4108WAV Transcriptional regulator HWQ22_RS11680 ENOG4105CNA YD repeat protein HWQ22_RS11715 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HWQ22_RS11735 ENOG4105D2S major facilitator superfamily HWQ22_RS11745 ENOG4105D1S lipid A biosynthesis HWQ22_RS11750 ENOG4105BZU Histidine kinase HWQ22_RS11755 ENOG4107AQZ Membrane HWQ22_RS11775 ENOG4108Z4U Ferredoxin HWQ22_RS11815 ENOG4105DFG type I secretion outer membrane protein HWQ22_RS11820 ENOG4108IUZ ABC transporter HWQ22_RS11825 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HWQ22_RS11840 ENOG4105C2X Arabinose 5-phosphate isomerase HWQ22_RS11900 ENOG4105II7 pyrroline-5-carboxylate reductase HWQ22_RS11910 ENOG4105VEQ Cold shock protein HWQ22_RS11915 ENOG410829K Lysine exporter protein (Lyse ygga) HWQ22_RS11945 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HWQ22_RS11995 ENOG4108KB2 LysR family Transcriptional regulator HWQ22_RS12000 ENOG4105FUY alpha subunit HWQ22_RS12005 ENOG4108UKV benzoate 1,2-dioxygenase HWQ22_RS12010 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HWQ22_RS12015 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HWQ22_RS12020 ENOG4105DKK Benzoate HWQ22_RS12025 ENOG4105D2S major facilitator superfamily HWQ22_RS12040 ENOG4105CQ7 ATP-dependent helicase HWQ22_RS12045 ENOG4105D3R alkyl hydroperoxide reductase HWQ22_RS12055 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HWQ22_RS12065 ENOG4108JU3 Alkyl hydroperoxide reductase HWQ22_RS12075 ENOG4108K3A Glutathione S-transferase HWQ22_RS12085 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HWQ22_RS12090 ENOG4108TGY Glutathione S-transferase HWQ22_RS12100 ENOG4108ZG0 Ompa motb domain protein HWQ22_RS12105 ENOG4105CD3 dihydroorotase HWQ22_RS12135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HWQ22_RS12150 ENOG4108UKZ OsmC family HWQ22_RS12155 ENOG4107RYR Transcriptional regulator, Crp Fnr family HWQ22_RS12165 ENOG4105CPC Aldo Keto reductase HWQ22_RS12180 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HWQ22_RS12190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HWQ22_RS12200 ENOG4105CFH Aspartokinase HWQ22_RS12210 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HWQ22_RS12220 ENOG4105CPW cytochrome b561 HWQ22_RS12225 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HWQ22_RS12230 ENOG4105C7N Xanthine uracil vitamin C permease HWQ22_RS12240 ENOG4105F95 Monooxygenase HWQ22_RS12265 ENOG4108BUD transposase HWQ22_RS12280 ENOG4108BUD transposase HWQ22_RS12285 ENOG4108C33 Resolvase HWQ22_RS12295 ENOG4108BUD transposase HWQ22_RS12310 ENOG4108BUD transposase HWQ22_RS12325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HWQ22_RS12345 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HWQ22_RS12365 ENOG4108JQ5 ABC transporter HWQ22_RS12370 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HWQ22_RS12375 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HWQ22_RS12385 ENOG4105E9H Lytic Murein transglycosylase HWQ22_RS12385 ENOG4105E9H Lytic Murein transglycosylase HWQ22_RS12390 ENOG4107RZZ dna polymerase iii epsilon subunit HWQ22_RS12400 ENOG4105E09 nadh pyrophosphatase HWQ22_RS12410 ENOG4105W4M Transport-associated protein HWQ22_RS12420 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HWQ22_RS12430 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HWQ22_RS12435 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HWQ22_RS12455 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HWQ22_RS12460 ENOG4105D0A hydroxylase HWQ22_RS12465 ENOG4107RAQ aminopeptidase HWQ22_RS12500 ENOG4105DIJ Phosphoethanolamine transferase HWQ22_RS12545 ENOG4105DR5 peptidase HWQ22_RS12870 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HWQ22_RS12895 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HWQ22_RS12905 ENOG4105D82 Glutamate dehydrogenase HWQ22_RS12910 ENOG4108R3D Electron transport complex HWQ22_RS12915 ENOG4105CSM endonuclease III HWQ22_RS12940 ENOG4105CJN penicillin-binding protein HWQ22_RS12945 ENOG4106H78 methyltransferase HWQ22_RS12960 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HWQ22_RS12970 ENOG4105CQM Urea amidohydrolase subunit alpha HWQ22_RS13000 ENOG4107RET Isocitrate lyase HWQ22_RS13010 ENOG4105C37 (CBS) domain HWQ22_RS13015 ENOG4105D4T Citrate transporter HWQ22_RS13030 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HWQ22_RS13050 ENOG4108MRJ HWQ22_RS13070 ENOG4105VCQ rubredoxin HWQ22_RS13075 ENOG4107QZF nitrite reductase NADPH large subunit HWQ22_RS13085 ENOG4105C5Q Transcriptional regulator HWQ22_RS13105 ENOG4107U91 Rhomboid family HWQ22_RS13110 ENOG4105CV6 ABC transporter, permease HWQ22_RS13115 ENOG4108I0Y (ABC) transporter HWQ22_RS13120 ENOG4108UJV acyl-CoA thioesterase i HWQ22_RS13140 ENOG4107RNH Outer membrane receptor FepA HWQ22_RS13155 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HWQ22_RS13160 ENOG4105E6M Sulphatase-modifying factor protein HWQ22_RS13180 ENOG4105CJ3 phosphate transporter HWQ22_RS13185 ENOG4105C3R Methionine synthase HWQ22_RS13200 ENOG4105CSP Major Facilitator Superfamily HWQ22_RS13210 ENOG4108PZW LysR family Transcriptional regulator HWQ22_RS13220 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HWQ22_RS13225 ENOG4105EU0 Major facilitator Superfamily HWQ22_RS13230 ENOG4108R6W Transcriptional regulator, ARAC family HWQ22_RS13235 ENOG4105CSV Glutaminase HWQ22_RS13240 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HWQ22_RS13245 ENOG4105CSH Transporter HWQ22_RS13255 ENOG4105C7K acetolactate synthase HWQ22_RS13270 ENOG4105CHR reductase HWQ22_RS13275 ENOG4108MXF Alpha Beta Hydrolase HWQ22_RS13285 ENOG4105DJB Major Facilitator Superfamily HWQ22_RS13290 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HWQ22_RS13300 ENOG4105CHR reductase HWQ22_RS13320 ENOG41069M3 Transcriptional regulator HWQ22_RS13335 ENOG4106YT9 Enoyl-CoA hydratase HWQ22_RS13345 ENOG4105CND Glycosyl transferase, family 2 HWQ22_RS13350 ENOG4107BJW polysaccharide deacetylase HWQ22_RS13360 ENOG4108VWS Yaeq family HWQ22_RS13370 ENOG4105CKI cobalamin synthesis protein HWQ22_RS13380 ENOG4108S4H thioesterase Superfamily protein HWQ22_RS13390 ENOG4105C94 Transporter HWQ22_RS13395 ENOG4105C94 Transporter HWQ22_RS13400 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HWQ22_RS13425 ENOG4107QK5 Homocysteine s-methyltransferase HWQ22_RS13430 ENOG4105D5Q Arginine ornithine antiporter HWQ22_RS13455 ENOG4108YNN Heme oxygenase HWQ22_RS13485 ENOG4108SF5 RNA Polymerase HWQ22_RS13495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HWQ22_RS13500 ENOG4105C54 Major Facilitator superfamily HWQ22_RS13520 ENOG4105F8V Hydrolase, tatD family HWQ22_RS13555 ENOG4108UUM single-stranded DNA-binding protein HWQ22_RS13610 ENOG4105DFP Integrase HWQ22_RS13625 ENOG4105KT5 UmuD protein HWQ22_RS13750 ENOG41090AG Bacteriophage protein HWQ22_RS13765 ENOG4107ZQ5 Phage-associated protein, HI1409 family HWQ22_RS13850 ENOG4105W7J DNA binding HWQ22_RS13855 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HWQ22_RS13920 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HWQ22_RS13925 ENOG4105C0R drug resistance transporter emrb qaca subfamily HWQ22_RS13930 ENOG4105CW7 secretion protein, HlyD family HWQ22_RS13935 ENOG4108VUY thioesterase Superfamily protein HWQ22_RS13940 ENOG4105D52 delta-aminolevulinic acid dehydratase HWQ22_RS13945 ENOG4105MWK D-amino acid dehydrogenase, small subunit HWQ22_RS13950 ENOG4105ECP epimerase HWQ22_RS13970 ENOG4107RH8 nuclease SbcCD subunit D HWQ22_RS13975 ENOG4105EYH Exonuclease HWQ22_RS13980 ENOG4105DFA alanine racemase domain protein HWQ22_RS13985 ENOG4105CZX twitching motility protein HWQ22_RS13990 ENOG4105CZX twitching motility protein HWQ22_RS13995 ENOG41090R7 Ferric uptake HWQ22_RS14020 ENOG4105E7A Glutamine amidotransferase HWQ22_RS14035 ENOG4107QKV phosphomannomutase HWQ22_RS14045 ENOG4105C4R Atp-dependent dna helicase HWQ22_RS14050 ENOG4108ZG0 Ompa motb domain protein HWQ22_RS14055 ENOG4106HNH Acyl-transferase HWQ22_RS14070 ENOG4107QMS site-determining protein HWQ22_RS14095 ENOG4105CCF Lysine exporter protein (Lyse ygga) HWQ22_RS14100 ENOG4105CNU cell division protein FtsK HWQ22_RS14105 ENOG4105C3M thioredoxin reductase HWQ22_RS14110 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HWQ22_RS14120 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HWQ22_RS14165 ENOG4108YXA Membrane HWQ22_RS14170 ENOG4105EUB pirin domain protein HWQ22_RS14180 ENOG4105C4K Nad synthetase HWQ22_RS14195 ENOG4105E3J oxidoreductase HWQ22_RS14200 ENOG4105C26 Dehydrogenase HWQ22_RS14205 ENOG4105DVW rieske (2Fe-2S) HWQ22_RS14215 ENOG4105C94 Transporter HWQ22_RS14220 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HWQ22_RS14225 ENOG4105EJC lysr family transcriptional regulator HWQ22_RS14245 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HWQ22_RS14265 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HWQ22_RS14270 ENOG4105C34 Pseudouridine synthase HWQ22_RS14275 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HWQ22_RS14280 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HWQ22_RS14295 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HWQ22_RS14325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HWQ22_RS14355 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HWQ22_RS14365 ENOG4105DWF phosphomethylpyrimidine kinase HWQ22_RS14370 ENOG4109066 lysm domain bon superfamily protein HWQ22_RS14380 ENOG4105CHR reductase HWQ22_RS14385 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HWQ22_RS14395 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HWQ22_RS14400 ENOG4108BPE -transporting atpase HWQ22_RS14405 ENOG4107RTD sua5 ycio yrdc ywlc family protein HWQ22_RS14410 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HWQ22_RS14415 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HWQ22_RS14420 ENOG4105FE9 pseudouridine synthase HWQ22_RS14430 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HWQ22_RS14435 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HWQ22_RS14445 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HWQ22_RS14450 ENOG4108K4C ec 3.1.3.12 HWQ22_RS14455 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HWQ22_RS14460 ENOG4106UW1 Major Facilitator superfamily HWQ22_RS14480 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HWQ22_RS14490 ENOG4105HF0 Membrane HWQ22_RS14505 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HWQ22_RS14515 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HWQ22_RS14565 ENOG4105D1F ATP-binding protein HWQ22_RS14575 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HWQ22_RS14605 ENOG4105K6H D-cysteine desulfhydrase HWQ22_RS14610 ENOG4105CBX hi0933 family HWQ22_RS14635 ENOG4105DP0 ferredoxin-NADP reductase HWQ22_RS14640 ENOG4105DUM transcriptional regulator, lysR family HWQ22_RS14660 ENOG4105C8S subunit m HWQ22_RS14665 ENOG4105D65 subunit l HWQ22_RS14675 ENOG4107UFS subunit j HWQ22_RS14690 ENOG4108IEH NADH dehydrogenase subunit g HWQ22_RS14695 ENOG4107QIZ NADH dehydrogenase HWQ22_RS14700 ENOG4105GKE subunit e HWQ22_RS14720 ENOG4105BZU Histidine kinase HWQ22_RS14730 ENOG4105E0F Histidine kinase HWQ22_RS14735 ENOG4107EXC regulatoR HWQ22_RS14745 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HWQ22_RS14755 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HWQ22_RS14765 ENOG4105EB3 Histidine kinase HWQ22_RS14835 ENOG4105DZG Dehydrogenase HWQ22_RS14860 ENOG4105JAB phenazine biosynthesis protein, phzf family HWQ22_RS14875 ENOG4105F9F transposase HWQ22_RS14890 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HWQ22_RS14905 ENOG4105ETT transcriptional Regulator, LysR family HWQ22_RS14925 ENOG4105CH2 amidohydrolase HWQ22_RS14935 ENOG4106P55 Transcriptional regulator HWQ22_RS14950 ENOG4106P55 Transcriptional regulator HWQ22_RS14955 ENOG4107EFR Flavocytochrome c HWQ22_RS14965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HWQ22_RS14970 ENOG4107RGD Major Facilitator superfamily HWQ22_RS14975 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS14980 ENOG4105ETT transcriptional Regulator, LysR family HWQ22_RS15015 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HWQ22_RS15020 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HWQ22_RS15025 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HWQ22_RS15040 ENOG4105VR0 copper resistance HWQ22_RS15045 ENOG4105E3B Multicopper oxidase HWQ22_RS15055 ENOG4108HCJ Hydrolase HWQ22_RS15060 ENOG4105DJV ribulose-phosphate 3-epimerase HWQ22_RS15085 ENOG41072GX Peptidase M22 Glycoprotease HWQ22_RS15090 ENOG4108Z0R Transferase HWQ22_RS15140 ENOG4105CRQ synthase (Component I) HWQ22_RS15150 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HWQ22_RS15155 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HWQ22_RS15160 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HWQ22_RS15230 ENOG4105K56 Transcriptional regulator HWQ22_RS15235 ENOG4108ZHJ Organic hydroperoxide resistance protein HWQ22_RS15240 ENOG4107QHF type ii secretion system protein e HWQ22_RS15270 ENOG4105C2M dna polymerase I HWQ22_RS15275 ENOG4108VIA integral membrane protein HWQ22_RS15280 ENOG4105II7 pyrroline-5-carboxylate reductase HWQ22_RS15285 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HWQ22_RS15295 ENOG4105C9X ppx gppa phosphatase HWQ22_RS15305 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HWQ22_RS15325 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HWQ22_RS15365 ENOG4105W39 Membrane HWQ22_RS15370 ENOG4105CYM Glutathione S-transferase HWQ22_RS15385 ENOG4105CEY Amp-dependent synthetase and ligase HWQ22_RS15390 ENOG4105N42 UPF0307 protein HWQ22_RS15395 ENOG41080Z8 PHOSPHOCARRIER protein HWQ22_RS15415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HWQ22_RS15420 ENOG4105DJ0 Poly(A) Polymerase HWQ22_RS15425 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HWQ22_RS15430 ENOG4105DXN mazG family HWQ22_RS15440 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HWQ22_RS15455 ENOG4105C6T cysteine synthase HWQ22_RS15460 ENOG4105BZU Histidine kinase HWQ22_RS15465 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HWQ22_RS15470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HWQ22_RS15475 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HWQ22_RS15490 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HWQ22_RS15495 ENOG4105W8H transhydrogenase (subunit alpha HWQ22_RS15500 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HWQ22_RS15505 ENOG4106UX7 integral membrane protein HWQ22_RS15520 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HWQ22_RS15530 ENOG4107RSM transcriptional regulator HWQ22_RS15540 ENOG4105CUZ uba thif-type nad fad binding protein HWQ22_RS15545 ENOG4107QM5 aconitate hydratase HWQ22_RS15550 ENOG4105F8V Hydrolase, tatD family HWQ22_RS15565 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HWQ22_RS15585 ENOG4105BZU Histidine kinase HWQ22_RS15595 ENOG4108ZP8 Acetolactate synthase small subunit HWQ22_RS15600 ENOG4105C7K acetolactate synthase HWQ22_RS15630 ENOG4105DJY efflux transporter, rnd family, mfp subunit HWQ22_RS15635 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HWQ22_RS15640 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HWQ22_RS15645 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HWQ22_RS15655 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HWQ22_RS15660 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HWQ22_RS15670 ENOG4105VW4 glutaredoxin 3 HWQ22_RS15690 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HWQ22_RS15710 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HWQ22_RS15730 ENOG4105WVQ Fe-S assembly protein IscX HWQ22_RS15745 ENOG4105CN1 protease HWQ22_RS15770 ENOG4105C26 Dehydrogenase HWQ22_RS15775 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HWQ22_RS15780 ENOG4105C6Z Gluconate HWQ22_RS15785 ENOG4108UHU Aldolase HWQ22_RS15790 ENOG4105C01 Dihydroxy-acid dehydratase HWQ22_RS15795 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HWQ22_RS15800 ENOG4108DNC Involved in acetate metabolism (By similarity) HWQ22_RS15805 ENOG4107GFK fumarate HWQ22_RS15825 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HWQ22_RS15835 ENOG4108ESX Receptor HWQ22_RS15845 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HWQ22_RS15855 ENOG4105DWV Homoserine O-trans-acetylase HWQ22_RS15955 ENOG4105CIY formyltetrahydrofolate deformylase HWQ22_RS15965 ENOG4107RGH Aldehyde dehydrogenase HWQ22_RS15980 ENOG4105CKD glutathione-regulated potassium-efflux system protein HWQ22_RS16000 ENOG4105VFU Rna-binding protein HWQ22_RS16005 ENOG4105C4R Atp-dependent dna helicase HWQ22_RS16020 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HWQ22_RS16030 ENOG4105KVH Transcriptional regulator HWQ22_RS16045 ENOG4105C5H ABC transporter HWQ22_RS16050 ENOG4105N14 lysine exporter protein LysE YggA HWQ22_RS16055 ENOG4105D1S lipid A biosynthesis HWQ22_RS16065 ENOG4105CK2 sodium dicarboxylate symporter HWQ22_RS16090 ENOG4105HDK L-asparaginase HWQ22_RS16120 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HWQ22_RS16145 ENOG4105DUM transcriptional regulator, lysR family HWQ22_RS16160 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HWQ22_RS16175 ENOG4108W5M transcriptional regulator HWQ22_RS16190 ENOG4105D29 Helix-turn-helix type 11 domain protein HWQ22_RS16195 ENOG4107XGZ Hydrolase HWQ22_RS16200 ENOG4105EI2 Pseudouridine synthase HWQ22_RS16205 ENOG4105C03 ribonuclease HWQ22_RS16210 ENOG4105J5T Amp-dependent synthetase and ligase HWQ22_RS16225 ENOG4105CBN LysR family transcriptional regulator HWQ22_RS16235 ENOG4105CSA Coproporphyrinogen iii oxidase HWQ22_RS16245 ENOG4107QI1 Mate efflux family protein HWQ22_RS16255 ENOG4107T8P acyl-Coa dehydrogenase HWQ22_RS16290 ENOG4105BZ8 glutamate synthase HWQ22_RS16300 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HWQ22_RS16305 ENOG4105C5X domain protein HWQ22_RS16320 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HWQ22_RS16330 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HWQ22_RS16340 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HWQ22_RS16345 ENOG4108JU5 Magnesium and cobalt efflux protein HWQ22_RS16350 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HWQ22_RS16355 ENOG4108Z7R Chaperone CsaA HWQ22_RS16365 ENOG4108VAU general secretion pathway protein G HWQ22_RS16370 ENOG4105D7Q type ii secretion system HWQ22_RS16375 ENOG4105C25 Primosomal protein n' HWQ22_RS16380 ENOG4105CKD glutathione-regulated potassium-efflux system protein HWQ22_RS16395 ENOG4105DVC DnaJ domain protein HWQ22_RS16400 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HWQ22_RS16405 ENOG4107QUT magnesium and cobalt transport protein CorA HWQ22_RS16425 ENOG4107QYX exodeoxyribonuclease v alpha HWQ22_RS16430 ENOG4107QKA exodeoxyribonuclease V beta HWQ22_RS16435 ENOG4105DSY exodeoxyribonuclease V, gamma HWQ22_RS16445 ENOG4105CSR polyphosphate kinase 2 HWQ22_RS16455 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HWQ22_RS16465 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HWQ22_RS16475 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HWQ22_RS16480 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HWQ22_RS16495 ENOG4105D65 subunit l HWQ22_RS16500 ENOG4108ZE9 Monovalent cation H antiporter subunit C HWQ22_RS16505 ENOG4107R4Z monovalent cation h antiporter subunit d HWQ22_RS16510 ENOG4105SC1 monovalent cation H antiporter subunit E HWQ22_RS16515 ENOG4105W4C monovalent cation H antiporter subunit F HWQ22_RS16520 ENOG4105KJM monovalent cation h antiporter subunit g HWQ22_RS16535 ENOG4105CHV Transcription elongation factor NusA HWQ22_RS16560 ENOG4107EJC Preprotein translocase subunit SecG HWQ22_RS16570 ENOG4107QHF type ii secretion system protein e HWQ22_RS16585 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HWQ22_RS16595 ENOG4105C2N RNA methyltransferase TrmH family group 3 HWQ22_RS16610 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HWQ22_RS16620 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HWQ22_RS16650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HWQ22_RS16655 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HWQ22_RS16710 ENOG4107ZXU DSBA oxidoreductase HWQ22_RS16725 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HWQ22_RS16740 ENOG4105D3Y Na H antiporter HWQ22_RS16795 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HWQ22_RS16800 ENOG4105PM1 preprotein translocase subunit SecE HWQ22_RS16840 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HWQ22_RS16845 ENOG4105TV9 FHA Domain-Containing protein HWQ22_RS16850 ENOG4105GVR general secretion pathway protein D HWQ22_RS16865 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HWQ22_RS16890 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HWQ22_RS16895 ENOG4108NEV two component transcriptional regulator, LytTR family HWQ22_RS16900 ENOG4108HRK Histidine kinase HWQ22_RS16915 ENOG4108UTW Plays a role in the regulation of phosphate uptake HWQ22_RS16925 ENOG4108RNG Permease of the drug metabolite transporter HWQ22_RS16950 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HWQ22_RS16960 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HWQ22_RS16965 ENOG4105CNI cell division protein FtsW HWQ22_RS16980 ENOG4105CE1 Ferrous iron transport protein b HWQ22_RS16990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HWQ22_RS16995 ENOG4105T95 Thiol disulfide interChange protein HWQ22_RS17000 ENOG4105D6E homoserine dehydrogenase HWQ22_RS17010 ENOG41061WM D-Alanyl-D-Alanine HWQ22_RS17020 ENOG4107TUY Histidine kinase HWQ22_RS17025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HWQ22_RS17030 ENOG4105CN1 protease HWQ22_RS17035 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HWQ22_RS17040 ENOG4108K5H permease YjgP YjgQ family protein HWQ22_RS17080 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HWQ22_RS17090 ENOG4105BZU Histidine kinase HWQ22_RS17105 ENOG4105C0P Mg chelatase subunit ChlI HWQ22_RS17115 ENOG4105CHH sulfate transporter HWQ22_RS17160 ENOG4105C0P Mg chelatase subunit ChlI HWQ22_RS17165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HWQ22_RS17175 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HWQ22_RS17185 ENOG4105EPF Outer membrane porin HWQ22_RS17190 ENOG4105F0N pyrophosphate phospho-hydrolase HWQ22_RS17205 ENOG4105CEY Amp-dependent synthetase and ligase HWQ22_RS17210 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HWQ22_RS17215 ENOG41079KZ Major Facilitator Superfamily HWQ22_RS17220 ENOG4105EN6 Membrane HWQ22_RS17230 ENOG4105EE5 Membrane protein terC HWQ22_RS17235 ENOG4108URH decarboxylase HWQ22_RS17240 ENOG4105C0R drug resistance transporter emrb qaca subfamily HWQ22_RS17250 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HWQ22_RS17265 ENOG4105CCT upf0313 protein HWQ22_RS17285 ENOG4105CS1 NAD(P)H quinone oxidoreductase HWQ22_RS17295 ENOG4105C6T cysteine synthase HWQ22_RS17330 ENOG4105Y7M Transcriptional regulator, TetR family HWQ22_RS17365 ENOG4105C79 DNA protecting protein DprA HWQ22_RS17380 ENOG4108IND Tetr family transcriptional regulator HWQ22_RS17385 ENOG4107RTG Major Facilitator superfamily HWQ22_RS17395 ENOG4108V06 Glutathione peroxidase HWQ22_RS17460 ENOG4105FDK ABC transporter HWQ22_RS17465 ENOG4105FAV ABC, transporter HWQ22_RS17470 ENOG410829K Lysine exporter protein (Lyse ygga) HWQ22_RS17475 ENOG4105EZR dyp-type peroxidase family protein HWQ22_RS17480 ENOG4107R1I NAD-dependent malic enzyme HWQ22_RS17505 ENOG4105EUB pirin domain protein HWQ22_RS17520 ENOG4106JUT Streptomycin 3''-adenylyltransferase HWQ22_RS17525 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HWQ22_RS17530 ENOG4106MP8 UPF0754 membrane protein HWQ22_RS17535 ENOG4108VBZ doxx family HWQ22_RS17540 ENOG4105DQR SNARE associated Golgi HWQ22_RS17555 ENOG4107QJE Chromosome Partitioning Protein HWQ22_RS17565 ENOG4107PSF BolA-like protein HWQ22_RS17610 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS17635 ENOG4105CSH Transporter HWQ22_RS17640 ENOG4105E39 Enoyl-CoA hydratase HWQ22_RS17645 ENOG4105E39 Enoyl-CoA hydratase HWQ22_RS17650 ENOG4105C1G acyl-Coa dehydrogenase HWQ22_RS17660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HWQ22_RS17665 ENOG4105C26 Dehydrogenase HWQ22_RS17675 ENOG4105C85 amino acid HWQ22_RS17680 ENOG4105C85 amino acid HWQ22_RS17685 ENOG4105M4H endoribonuclease L-psp HWQ22_RS17700 ENOG4105EW9 transcriptional regulator AsnC family HWQ22_RS17725 ENOG4105D3G Pseudouridine synthase HWQ22_RS17770 ENOG4108I0Z Aconitate hydratase HWQ22_RS17775 ENOG4105BZN citrate synthase HWQ22_RS17780 ENOG4105CR4 methylisocitrate lyase HWQ22_RS17785 ENOG4105DRR Transcriptional regulator, GntR family HWQ22_RS17795 ENOG4105CGF Aromatic amino acid aminotransferase HWQ22_RS17800 ENOG4105CXG d-lactate dehydrogenase HWQ22_RS17810 ENOG41073TP transcriptional regulator HWQ22_RS17815 ENOG4105DAA L-lactate HWQ22_RS17820 ENOG4107QKV phosphomannomutase HWQ22_RS17830 ENOG4105CMR udp-glucose 4-epimerase HWQ22_RS17840 ENOG4105C6Y Udp-glucose 6-dehydrogenase HWQ22_RS17845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HWQ22_RS17850 ENOG4105D3Q Sugar transferase HWQ22_RS17855 ENOG4108RYC glycosyltransferase HWQ22_RS17860 ENOG4105CG5 Glycosyl transferase (Group 1 HWQ22_RS17870 ENOG4107VDP teichoic acid biosynthesis HWQ22_RS17885 ENOG4107QQG Dehydrogenase HWQ22_RS17890 ENOG4105DAY polysaccharide export protein HWQ22_RS17900 ENOG4105D75 Capsular exopolysaccharide family HWQ22_RS17905 ENOG4108V1T peptidylprolyl cis-trans isomerase HWQ22_RS17910 ENOG4108V1T peptidylprolyl cis-trans isomerase HWQ22_RS17915 ENOG4105CJR Integral membrane protein (MviN HWQ22_RS17920 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HWQ22_RS17925 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HWQ22_RS17935 ENOG4105HSS phospholipase C HWQ22_RS17955 ENOG4105EJ2 Transcriptional regulator HWQ22_RS17960 ENOG41062JF Transcriptional regulator HWQ22_RS17965 ENOG4108Z33 Thiol disulfide Interchange Protein HWQ22_RS17975 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HWQ22_RS17980 ENOG4105UBK short-chain dehydrogenase reductase HWQ22_RS17995 ENOG4107QZM n-acetylglutamate synthase HWQ22_RS18000 ENOG4105GVF (ABC) transporter HWQ22_RS18005 ENOG4105GVF (ABC) transporter HWQ22_RS18010 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HWQ22_RS18015 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HWQ22_RS18020 ENOG4108VM9 ABC, transporter HWQ22_RS18025 ENOG4108R86 Transcriptional regulator HWQ22_RS18030 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HWQ22_RS18040 ENOG4105DTN riboflavin biosynthesis protein ribF HWQ22_RS18045 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HWQ22_RS18055 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HWQ22_RS18095 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HWQ22_RS18150 ENOG4105CVE Lytic murein transglycosylase HWQ22_RS18155 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HWQ22_RS18160 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HWQ22_RS18170 ENOG4105DFU Cell wall formation (By similarity) HWQ22_RS18180 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HWQ22_RS18185 ENOG4105DU1 integral membrane protein, terc HWQ22_RS18195 ENOG4106032 Glutathionylspermidine synthase HWQ22_RS18205 ENOG4107QUY Guanine deaminase HWQ22_RS18210 ENOG4108UGV hypoxanthine phosphoribosyltransferase HWQ22_RS18220 ENOG4105T95 Thiol disulfide interChange protein HWQ22_RS18225 ENOG4105PGM cation diffusion facilitator family transporter HWQ22_RS18240 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HWQ22_RS18290 ENOG4105UGU tonB-dependent Receptor