locus-tag	class	description
HWQ22_RS00010	COG0592	DNA-directed DNA polymerase activity
HWQ22_RS00020	COG0187	DNA topoisomerase II activity
HWQ22_RS00030	COG0586	Pfam SNARE associated Golgi protein
HWQ22_RS00035	COG0488	(ABC) transporter
HWQ22_RS00060	COG0596	Alpha beta hydrolase
HWQ22_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HWQ22_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWQ22_RS00110	COG0733	neurotransmitter:sodium symporter activity
HWQ22_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWQ22_RS00145	COG0583	DNA-binding transcription factor activity
HWQ22_RS00150	COG2233	PERMEase
HWQ22_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS00200	COG2814	Major facilitator Superfamily
HWQ22_RS00205	COG0656	L-ascorbic acid biosynthetic process
HWQ22_RS00210	COG0583	DNA-binding transcription factor activity
HWQ22_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_RS00230	COG1064	alcohol dehydrogenase
HWQ22_RS00235	COG2818	Glycosylase
HWQ22_RS00250	COG1194	a g-specific adenine glycosylase
HWQ22_RS00270	COG2983	Belongs to the UPF0260 family
HWQ22_RS00275	COG2133	pyrroloquinoline quinone binding
HWQ22_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWQ22_RS00285	COG2116	formate transmembrane transporter activity
HWQ22_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_RS00310	COG1335	isochorismatase
HWQ22_RS00315	COG0385	Bile acid
HWQ22_RS00320	COG0534	Mate efflux family protein
HWQ22_RS00325	COG1683	Conserved Protein
HWQ22_RS00345	COG0625	glutathione transferase activity
HWQ22_RS00355	COG1113	amino acid transport
HWQ22_RS00365	COG0523	cobalamin synthesis protein
HWQ22_RS00375	COG2188	Transcriptional regulator
HWQ22_RS00405	COG0010	Belongs to the arginase family
HWQ22_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWQ22_RS00440	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HWQ22_RS00445	COG0732	type I restriction modification DNA specificity domain
HWQ22_RS00475	COG4584	PFAM Integrase catalytic
HWQ22_RS00535	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_RS00540	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HWQ22_RS00550	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_RS00600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWQ22_RS00610	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWQ22_RS00615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWQ22_RS00715	COG0534	Mate efflux family protein
HWQ22_RS00720	COG0436	Aminotransferase
HWQ22_RS00725	COG2733	membrane
HWQ22_RS00740	COG2918	glutathione biosynthetic process
HWQ22_RS00750	COG3501	Rhs element vgr protein
HWQ22_RS00755	COG0791	NLP P60 protein
HWQ22_RS00755	COG1388	LysM domain
HWQ22_RS00770	COG3150	esterase
HWQ22_RS00780	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS00785	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HWQ22_RS00795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_RS00805	COG2233	PERMEase
HWQ22_RS00810	COG2351	hydroxyisourate hydrolase activity
HWQ22_RS00845	COG3706	GGDEF domain
HWQ22_RS00860	COG1393	Belongs to the ArsC family
HWQ22_RS00865	COG0708	Exodeoxyribonuclease III
HWQ22_RS00885	COG0189	ligase activity
HWQ22_RS00905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWQ22_RS00915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWQ22_RS00930	COG4942	peptidase
HWQ22_RS00940	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWQ22_RS00950	COG2119	membrane
HWQ22_RS00955	COG4774	siderophore transport
HWQ22_RS00960	COG0426	domain, Protein
HWQ22_RS00960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_RS00985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWQ22_RS01005	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_RS01010	COG1519	Transferase
HWQ22_RS01015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWQ22_RS01020	COG0668	transmembrane transport
HWQ22_RS01030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_RS01035	COG1335	isochorismatase
HWQ22_RS01040	COG1522	sequence-specific DNA binding
HWQ22_RS01045	COG3328	transposase activity
HWQ22_RS01070	COG2205	protein histidine kinase activity
HWQ22_RS01070	COG2198	Histidine kinase
HWQ22_RS01070	COG0784	Response regulator, receiver
HWQ22_RS01075	COG3162	membrane
HWQ22_RS01080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ22_RS01090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_RS01100	COG3706	GGDEF domain
HWQ22_RS01110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWQ22_RS01115	COG1309	transcriptional regulator
HWQ22_RS01135	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_RS01135	COG0351	phosphomethylpyrimidine kinase
HWQ22_RS01135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWQ22_RS01145	COG2814	Major facilitator Superfamily
HWQ22_RS01160	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWQ22_RS01170	COG1113	amino acid transport
HWQ22_RS01180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWQ22_RS01185	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS01195	COG1335	isochorismatase
HWQ22_RS01225	COG2814	Major facilitator Superfamily
HWQ22_RS01230	COG0583	DNA-binding transcription factor activity
HWQ22_RS01250	COG0667	Aldo Keto reductase
HWQ22_RS01280	COG1733	regulation of RNA biosynthetic process
HWQ22_RS01285	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_RS01360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWQ22_RS01375	COG2329	Antibiotic biosynthesis monooxygenase
HWQ22_RS01405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWQ22_RS01435	COG0427	acetyl-CoA hydrolase
HWQ22_RS01450	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS01460	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_RS01465	COG4221	oxidoreductase activity
HWQ22_RS01470	COG2873	o-acetylhomoserine
HWQ22_RS01475	COG0488	(ABC) transporter
HWQ22_RS01560	COG0833	amino acid
HWQ22_RS01605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWQ22_RS01610	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWQ22_RS01625	COG2226	methyltransferase
HWQ22_RS01675	COG0070	glutamate synthase
HWQ22_RS01675	COG0069	glutamate synthase activity
HWQ22_RS01675	COG0067	glutamate synthase
HWQ22_RS01680	COG0493	'glutamate synthase
HWQ22_RS01690	COG1704	LemA family
HWQ22_RS01695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWQ22_RS01715	COG3307	-O-antigen
HWQ22_RS01735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ22_RS01750	COG0194	GDP metabolic process
HWQ22_RS01800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWQ22_RS01820	COG5380	lipid catabolic process
HWQ22_RS01825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWQ22_RS01850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWQ22_RS01855	COG0277	FAD linked oxidase domain protein
HWQ22_RS01865	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWQ22_RS01870	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_RS01885	COG1289	transmembrane transporter activity
HWQ22_RS01895	COG0628	permease
HWQ22_RS01900	COG1192	Involved in chromosome partitioning
HWQ22_RS01930	COG0833	amino acid
HWQ22_RS01935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWQ22_RS01940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWQ22_RS01950	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS01990	COG0583	DNA-binding transcription factor activity
HWQ22_RS02035	COG0517	IMP dehydrogenase activity
HWQ22_RS02040	COG1983	PspC domain protein
HWQ22_RS02050	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS02065	COG0408	coproporphyrinogen oxidase activity
HWQ22_RS02085	COG0513	Belongs to the DEAD box helicase family
HWQ22_RS02095	COG1127	ABC transporter
HWQ22_RS02100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWQ22_RS02110	COG2854	intermembrane phospholipid transfer
HWQ22_RS02120	COG0598	Magnesium transport protein CorA
HWQ22_RS02130	COG0494	nUDIX hydrolase
HWQ22_RS02135	COG1040	competence protein
HWQ22_RS02140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWQ22_RS02160	COG1946	Acyl-CoA thioesterase
HWQ22_RS02165	COG1301	dicarboxylic acid transport
HWQ22_RS02180	COG1959	2 iron, 2 sulfur cluster binding
HWQ22_RS02185	COG1017	nitric oxide dioxygenase activity
HWQ22_RS02185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_RS02190	COG0433	COG0433 Predicted ATPase
HWQ22_RS02195	COG0626	cystathionine gamma-synthase activity
HWQ22_RS02350	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS02355	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HWQ22_RS02385	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HWQ22_RS02390	COG0339	signal peptide processing
HWQ22_RS02395	COG0557	exoribonuclease II activity
HWQ22_RS02440	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWQ22_RS02445	COG2169	Transcriptional regulator
HWQ22_RS02450	COG0697	spore germination
HWQ22_RS02455	COG1295	ribonuclease BN
HWQ22_RS02490	COG1702	phosphate starvation-inducible protein PhoH
HWQ22_RS02500	COG1196	nuclear chromosome segregation
HWQ22_RS02500	COG0739	heme binding
HWQ22_RS02500	COG0741	lytic transglycosylase activity
HWQ22_RS02530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWQ22_RS02535	COG1183	phosphatidylcholine synthase activity
HWQ22_RS02580	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS02585	COG1309	transcriptional regulator
HWQ22_RS02600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ22_RS02605	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS02625	COG2969	positive regulation of protein catabolic process
HWQ22_RS02635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWQ22_RS02650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWQ22_RS02655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWQ22_RS02675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWQ22_RS02685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ22_RS02690	COG1408	metallophosphoesterase
HWQ22_RS02720	COG1061	Type III restriction enzyme res subunit
HWQ22_RS02795	COG1607	acyl-coa hydrolase
HWQ22_RS02825	COG2350	Protein conserved in bacteria
HWQ22_RS02835	COG0613	PHP domain protein
HWQ22_RS02840	COG3781	membrane
HWQ22_RS02850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWQ22_RS02855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWQ22_RS02865	COG1862	Preprotein translocase
HWQ22_RS02895	COG2205	protein histidine kinase activity
HWQ22_RS02900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HWQ22_RS02920	COG0726	polysaccharide deacetylase
HWQ22_RS02925	COG0463	Glycosyl transferase, family 2
HWQ22_RS02930	COG0438	transferase activity, transferring glycosyl groups
HWQ22_RS02995	COG0625	glutathione transferase activity
HWQ22_RS03000	COG0583	DNA-binding transcription factor activity
HWQ22_RS03005	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS03010	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS03020	COG2205	protein histidine kinase activity
HWQ22_RS03025	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS03030	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HWQ22_RS03050	COG2096	Adenosyltransferase
HWQ22_RS03100	COG0285	dihydrofolate synthase activity
HWQ22_RS03120	COG0450	alkyl hydroperoxide reductase
HWQ22_RS03135	COG0477	Major facilitator Superfamily
HWQ22_RS03140	COG1272	protein, Hemolysin III
HWQ22_RS03170	COG0183	Belongs to the thiolase family
HWQ22_RS03175	COG2207	Transcriptional regulator
HWQ22_RS03195	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_RS03215	COG0183	Belongs to the thiolase family
HWQ22_RS03225	COG2885	chlorophyll binding
HWQ22_RS03225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HWQ22_RS03235	COG1690	Belongs to the RtcB family
HWQ22_RS03240	COG0833	amino acid
HWQ22_RS03250	COG2233	PERMEase
HWQ22_RS03280	COG2094	Belongs to the DNA glycosylase MPG family
HWQ22_RS03285	COG4772	TonB-dependent receptor
HWQ22_RS03300	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_RS03305	COG0679	Auxin Efflux Carrier
HWQ22_RS03315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_RS03320	COG0354	folic acid binding
HWQ22_RS03330	COG3189	MarR family transcriptional regulator
HWQ22_RS03335	COG2824	Alkylphosphonate utilization operon protein PhnA
HWQ22_RS03340	COG3422	double-strand break repair
HWQ22_RS03380	COG0840	transmembrane signaling receptor activity
HWQ22_RS03400	COG5510	response to toxic substance
HWQ22_RS03410	COG2832	Protein of unknown function (DUF454)
HWQ22_RS03415	COG1376	ErfK ybiS ycfS ynhG family protein
HWQ22_RS03455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWQ22_RS03465	COG1289	transmembrane transporter activity
HWQ22_RS03470	COG2814	Major facilitator Superfamily
HWQ22_RS03490	COG1115	amino acid carrier protein
HWQ22_RS03495	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWQ22_RS03500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ22_RS03505	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HWQ22_RS03545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWQ22_RS03555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWQ22_RS03560	COG1077	Cell shape determining protein MreB Mrl
HWQ22_RS03565	COG1792	Involved in formation and maintenance of cell shape
HWQ22_RS03570	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWQ22_RS03575	COG0424	maF-like protein
HWQ22_RS03580	COG1530	ribonuclease E activity
HWQ22_RS03590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_RS03600	COG0560	Phosphoserine phosphatase
HWQ22_RS03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_RS03635	COG2207	Transcriptional regulator
HWQ22_RS03655	COG1113	amino acid transport
HWQ22_RS03660	COG2828	Protein conserved in bacteria
HWQ22_RS03665	COG0142	geranyltranstransferase activity
HWQ22_RS03670	COG2315	Protein conserved in bacteria
HWQ22_RS03685	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWQ22_RS03705	COG2194	sulfuric ester hydrolase activity
HWQ22_RS03710	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS03715	COG0642	Histidine kinase
HWQ22_RS03725	COG0004	ammonium transporteR
HWQ22_RS03730	COG0583	DNA-binding transcription factor activity
HWQ22_RS03750	COG0525	valine-tRNA ligase activity
HWQ22_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS03770	COG0393	Putative heavy-metal-binding
HWQ22_RS03775	COG0393	Putative heavy-metal-binding
HWQ22_RS03780	COG1538	Outer membrane efflux protein
HWQ22_RS03790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS03795	COG0671	phosphoesterase, PA-phosphatase related
HWQ22_RS03825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWQ22_RS03840	COG1648	precorrin-2 dehydrogenase activity
HWQ22_RS03840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWQ22_RS03845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWQ22_RS03850	COG1733	regulation of RNA biosynthetic process
HWQ22_RS03860	COG0531	amino acid
HWQ22_RS03875	COG0321	lipoyl(octanoyl) transferase activity
HWQ22_RS03880	COG2921	Belongs to the UPF0250 family
HWQ22_RS03925	COG2009	succinate dehydrogenase
HWQ22_RS03930	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HWQ22_RS03935	COG1053	succinate dehydrogenase
HWQ22_RS03940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWQ22_RS03965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_RS03985	COG2354	Protein conserved in bacteria
HWQ22_RS03990	COG2321	neutral zinc metallopeptidase
HWQ22_RS04045	COG2843	Capsule synthesis protein
HWQ22_RS04060	COG0589	response to stress
HWQ22_RS04080	COG0505	Belongs to the CarA family
HWQ22_RS04105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWQ22_RS04110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWQ22_RS04160	COG0477	Major facilitator Superfamily
HWQ22_RS04165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWQ22_RS04180	COG1597	lipid kinase activity
HWQ22_RS04185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWQ22_RS04195	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_RS04225	COG0584	glycerophosphoryl diester phosphodiesterase
HWQ22_RS04245	COG0741	lytic transglycosylase activity
HWQ22_RS04265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWQ22_RS04280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_RS04305	COG0778	Nitroreductase
HWQ22_RS04320	COG1929	Belongs to the glycerate kinase type-1 family
HWQ22_RS04325	COG0243	molybdopterin cofactor binding
HWQ22_RS04330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWQ22_RS04335	COG3339	Conserved Protein
HWQ22_RS04345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HWQ22_RS04360	COG1113	amino acid transport
HWQ22_RS04370	COG0019	diaminopimelate decarboxylase activity
HWQ22_RS04380	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS04385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HWQ22_RS04415	COG0463	Glycosyl transferase, family 2
HWQ22_RS04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS04470	COG4591	ABC-type transport system involved in lipoprotein release permease component
HWQ22_RS04475	COG1136	(ABC) transporter
HWQ22_RS04480	COG0658	competence protein
HWQ22_RS04480	COG2333	competence protein COMEC
HWQ22_RS04490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWQ22_RS04490	COG0616	signal peptide processing
HWQ22_RS04495	COG0596	Alpha beta hydrolase
HWQ22_RS04500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWQ22_RS04510	COG0628	permease
HWQ22_RS04545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWQ22_RS04565	COG0823	Involved in the tonB-independent uptake of proteins
HWQ22_RS04585	COG0824	Thioesterase
HWQ22_RS04590	COG1473	amidohydrolase
HWQ22_RS04610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWQ22_RS04610	COG0047	phosphoribosylformylglycinamidine synthase activity
HWQ22_RS04615	COG2814	Major facilitator Superfamily
HWQ22_RS04625	COG1024	Enoyl-CoA hydratase
HWQ22_RS04630	COG1056	cytidyltransferase-related domain
HWQ22_RS04630	COG1051	belongs to the nudix hydrolase family
HWQ22_RS04640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWQ22_RS04655	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWQ22_RS04670	COG4625	pathogenesis
HWQ22_RS04680	COG0583	DNA-binding transcription factor activity
HWQ22_RS04685	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HWQ22_RS04690	COG4208	sulfate ABC transporter
HWQ22_RS04695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HWQ22_RS04705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWQ22_RS04710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWQ22_RS04715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWQ22_RS04735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ22_RS04750	COG0681	Belongs to the peptidase S26 family
HWQ22_RS04765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWQ22_RS04775	COG1381	Involved in DNA repair and RecF pathway recombination
HWQ22_RS04780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HWQ22_RS04790	COG4221	oxidoreductase activity
HWQ22_RS04820	COG0436	Aminotransferase
HWQ22_RS04840	COG0556	nucleotide-excision repair
HWQ22_RS04895	COG2070	2-Nitropropane dioxygenase
HWQ22_RS04925	COG1215	transferase activity, transferring glycosyl groups
HWQ22_RS04940	COG0415	Belongs to the DNA photolyase family
HWQ22_RS04950	COG1252	NADH dehydrogenase
HWQ22_RS04955	COG1686	Belongs to the peptidase S11 family
HWQ22_RS04970	COG1187	pseudouridine synthase activity
HWQ22_RS04995	COG0477	Major facilitator Superfamily
HWQ22_RS05000	COG0583	DNA-binding transcription factor activity
HWQ22_RS05015	COG0612	Peptidase, M16
HWQ22_RS05040	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_RS05075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_RS05090	COG1309	transcriptional regulator
HWQ22_RS05100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWQ22_RS05105	COG0076	glutamate decarboxylase activity
HWQ22_RS05115	COG1522	sequence-specific DNA binding
HWQ22_RS05120	COG3961	Belongs to the TPP enzyme family
HWQ22_RS05125	COG1113	amino acid transport
HWQ22_RS05130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWQ22_RS05135	COG0573	inorganic phosphate transmembrane transporter activity
HWQ22_RS05145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWQ22_RS05150	COG0616	signal peptide processing
HWQ22_RS05160	COG3328	transposase activity
HWQ22_RS05190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWQ22_RS05195	COG1686	Belongs to the peptidase S11 family
HWQ22_RS05220	COG0583	DNA-binding transcription factor activity
HWQ22_RS05225	COG1067	ATP-dependent peptidase activity
HWQ22_RS05270	COG1966	Carbon starvation protein
HWQ22_RS05275	COG2879	small protein
HWQ22_RS05305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWQ22_RS05305	COG2508	Transcriptional regulator
HWQ22_RS05325	COG1113	amino acid transport
HWQ22_RS05335	COG0583	DNA-binding transcription factor activity
HWQ22_RS05340	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_RS05345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_RS05355	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS05360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_RS05365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_RS05365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWQ22_RS05400	COG2814	Major facilitator Superfamily
HWQ22_RS05405	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ22_RS05415	COG1309	transcriptional regulator
HWQ22_RS05435	COG1741	Belongs to the pirin family
HWQ22_RS05445	COG2964	Protein conserved in bacteria
HWQ22_RS05460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_RS05465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWQ22_RS05470	COG4605	iron ion homeostasis
HWQ22_RS05475	COG4604	ABC transporter, ATP-binding protein
HWQ22_RS05480	COG4607	ABC-type enterochelin transport system periplasmic component
HWQ22_RS05485	COG4774	siderophore transport
HWQ22_RS05495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWQ22_RS05500	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWQ22_RS05505	COG1535	isochorismatase
HWQ22_RS05505	COG3433	isochorismatase activity
HWQ22_RS05520	COG1132	(ABC) transporter
HWQ22_RS05530	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HWQ22_RS05540	COG1169	isochorismate synthase
HWQ22_RS05555	COG3739	integral membrane protein
HWQ22_RS05590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWQ22_RS05620	COG0308	aminopeptidase N
HWQ22_RS05625	COG0512	Glutamine amidotransferase of anthranilate synthase
HWQ22_RS05635	COG3104	oligopeptide transport
HWQ22_RS05640	COG0174	glutamine synthetase
HWQ22_RS05650	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWQ22_RS05685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWQ22_RS05690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWQ22_RS05695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWQ22_RS05715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWQ22_RS05720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWQ22_RS05725	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWQ22_RS05740	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS05745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWQ22_RS05750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_RS05760	COG2223	nitrite transmembrane transporter activity
HWQ22_RS05770	COG0024	Methionine aminopeptidase
HWQ22_RS05775	COG0052	Belongs to the universal ribosomal protein uS2 family
HWQ22_RS05790	COG2207	Transcriptional regulator
HWQ22_RS05815	COG2951	lytic endotransglycosylase activity
HWQ22_RS05820	COG0772	Belongs to the SEDS family
HWQ22_RS05835	COG0842	Transport permease protein
HWQ22_RS05840	COG1131	(ABC) transporter
HWQ22_RS05885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS05900	COG4215	(ABC) transporter
HWQ22_RS05905	COG4160	amino acid transport
HWQ22_RS05910	COG4598	ABC transporter
HWQ22_RS05920	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ22_RS05930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_RS05945	COG1720	tRNA m6t6A37 methyltransferase activity
HWQ22_RS05965	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS05970	COG0642	Histidine kinase
HWQ22_RS05980	COG0494	nUDIX hydrolase
HWQ22_RS05990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWQ22_RS05995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWQ22_RS06000	COG3139	Protein of unknown function (DUF1315)
HWQ22_RS06005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWQ22_RS06010	COG1301	dicarboxylic acid transport
HWQ22_RS06015	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS06020	COG2819	hydrolase of the alpha beta superfamily
HWQ22_RS06030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWQ22_RS06040	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWQ22_RS06045	COG1234	tRNA 3'-trailer cleavage
HWQ22_RS06075	COG2363	Small membrane protein
HWQ22_RS06095	COG0513	Belongs to the DEAD box helicase family
HWQ22_RS06105	COG0778	Nitroreductase
HWQ22_RS06135	COG1286	toxin biosynthetic process
HWQ22_RS06160	COG4783	chaperone-mediated protein folding
HWQ22_RS06165	COG1610	YqeY-like protein
HWQ22_RS06265	COG3111	PFAM Bacterial OB fold (BOF) protein
HWQ22_RS06290	COG3243	poly(R)-hydroxyalkanoic acid synthase
HWQ22_RS06295	COG0786	glutamate:sodium symporter activity
HWQ22_RS06305	COG2186	Transcriptional regulator
HWQ22_RS06320	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_RS06360	COG0477	Major facilitator Superfamily
HWQ22_RS06385	COG2985	domain, Protein
HWQ22_RS06395	COG2995	paraquat-inducible protein a
HWQ22_RS06400	COG3008	intermembrane lipid transfer
HWQ22_RS06400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWQ22_RS06410	COG1794	racemase activity, acting on amino acids and derivatives
HWQ22_RS06485	COG0482	sulfurtransferase activity
HWQ22_RS06505	COG3173	Aminoglycoside phosphotransferase
HWQ22_RS06515	COG2433	Pfam Transposase IS66
HWQ22_RS06555	COG1301	dicarboxylic acid transport
HWQ22_RS06565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_RS06570	COG2011	ABC-type metal ion transport system permease component
HWQ22_RS06575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWQ22_RS06580	COG1464	Belongs to the NlpA lipoprotein family
HWQ22_RS06585	COG0151	Belongs to the GarS family
HWQ22_RS06590	COG0138	bifunctional purine biosynthesis protein purh
HWQ22_RS06595	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HWQ22_RS06625	COG2308	Evidence 4 Homologs of previously reported genes of
HWQ22_RS06635	COG1305	Transglutaminase-like
HWQ22_RS06645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWQ22_RS06650	COG0305	Participates in initiation and elongation during chromosome replication
HWQ22_RS06675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWQ22_RS06685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWQ22_RS06690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWQ22_RS06715	COG1649	PFAM Uncharacterised BCR, COG1649
HWQ22_RS06715	COG0726	polysaccharide deacetylase
HWQ22_RS06720	COG1215	transferase activity, transferring glycosyl groups
HWQ22_RS06725	COG3658	cytochrome
HWQ22_RS06735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_RS06750	COG0583	DNA-binding transcription factor activity
HWQ22_RS06770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_RS06775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_RS06790	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS06795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_RS06800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_RS06825	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HWQ22_RS06830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HWQ22_RS06840	COG2205	protein histidine kinase activity
HWQ22_RS06845	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS06850	COG0174	glutamine synthetase
HWQ22_RS06870	COG0729	surface antigen
HWQ22_RS06895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ22_RS06900	COG2814	Major facilitator Superfamily
HWQ22_RS06915	COG0583	DNA-binding transcription factor activity
HWQ22_RS06930	COG1187	pseudouridine synthase activity
HWQ22_RS06950	COG0802	atpase or kinase
HWQ22_RS06955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWQ22_RS06965	COG1923	regulation of RNA biosynthetic process
HWQ22_RS06970	COG0697	spore germination
HWQ22_RS06985	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_RS06995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWQ22_RS07000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWQ22_RS07000	COG0519	Catalyzes the synthesis of GMP from XMP
HWQ22_RS07005	COG4302	ethanolamine ammonia-lyase activity
HWQ22_RS07010	COG4303	Ethanolamine ammonia lyase large subunit
HWQ22_RS07015	COG0531	amino acid
HWQ22_RS07035	COG1454	alcohol dehydrogenase
HWQ22_RS07040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWQ22_RS07050	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HWQ22_RS07070	COG0308	aminopeptidase N
HWQ22_RS07100	COG1605	Chorismate mutase
HWQ22_RS07115	COG1309	transcriptional regulator
HWQ22_RS07125	COG0668	transmembrane transport
HWQ22_RS07165	COG4773	Receptor
HWQ22_RS07185	COG0488	(ABC) transporter
HWQ22_RS07190	COG0589	response to stress
HWQ22_RS07215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWQ22_RS07225	COG3135	benzoate transporter
HWQ22_RS07230	COG1522	sequence-specific DNA binding
HWQ22_RS07240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWQ22_RS07245	COG0583	DNA-binding transcription factor activity
HWQ22_RS07255	COG0183	Belongs to the thiolase family
HWQ22_RS07265	COG2030	dehydratase
HWQ22_RS07285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWQ22_RS07295	COG0824	Thioesterase
HWQ22_RS07300	COG1454	alcohol dehydrogenase
HWQ22_RS07310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWQ22_RS07330	COG0069	glutamate synthase activity
HWQ22_RS07350	COG2814	Major facilitator Superfamily
HWQ22_RS07365	COG0511	ligase activity, forming carbon-carbon bonds
HWQ22_RS07385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_RS07385	COG1116	anion transmembrane transporter activity
HWQ22_RS07390	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS07400	COG2146	nitrite reductase [NAD(P)H] activity
HWQ22_RS07400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_RS07405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_RS07410	COG0243	molybdopterin cofactor binding
HWQ22_RS07420	COG0243	molybdopterin cofactor binding
HWQ22_RS07425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWQ22_RS07440	COG0315	cyclic pyranopterin monophosphate synthase activity
HWQ22_RS07440	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWQ22_RS07445	COG0303	'Molybdopterin
HWQ22_RS07455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_RS07460	COG0697	spore germination
HWQ22_RS07480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HWQ22_RS07485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWQ22_RS07540	COG2204	response regulator
HWQ22_RS07545	COG3852	Histidine kinase
HWQ22_RS07565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWQ22_RS07570	COG0575	Belongs to the CDS family
HWQ22_RS07605	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_RS07620	COG2137	regulation of response to DNA damage stimulus
HWQ22_RS07630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWQ22_RS07635	COG1011	Hydrolase
HWQ22_RS07660	COG1522	sequence-specific DNA binding
HWQ22_RS07670	COG1113	amino acid transport
HWQ22_RS07685	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_RS07690	COG2135	peptidase activity
HWQ22_RS07705	COG5001	Diguanylate cyclase
HWQ22_RS07705	COG3300	MHYT domain
HWQ22_RS07725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ22_RS07725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HWQ22_RS07725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWQ22_RS07730	COG1105	Belongs to the carbohydrate kinase PfkB family
HWQ22_RS07735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWQ22_RS07735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWQ22_RS07765	COG0024	Methionine aminopeptidase
HWQ22_RS07770	COG0583	DNA-binding transcription factor activity
HWQ22_RS07780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWQ22_RS07785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWQ22_RS07790	COG0516	GMP reductase activity
HWQ22_RS07790	COG0517	IMP dehydrogenase activity
HWQ22_RS07815	COG0552	protein localization to endoplasmic reticulum
HWQ22_RS07825	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HWQ22_RS07840	COG4890	Cyd operon protein YbgT
HWQ22_RS07845	COG1294	oxidase, subunit
HWQ22_RS07865	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWQ22_RS07875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWQ22_RS07880	COG4774	siderophore transport
HWQ22_RS07895	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWQ22_RS07900	COG0569	domain protein
HWQ22_RS07905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWQ22_RS07935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HWQ22_RS07940	COG0542	response to heat
HWQ22_RS07965	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_RS07965	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_RS08010	COG2323	membrane
HWQ22_RS08015	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWQ22_RS08025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_RS08030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_RS08035	COG0183	Belongs to the thiolase family
HWQ22_RS08040	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWQ22_RS08045	COG0596	Alpha beta hydrolase
HWQ22_RS08050	COG2271	Major facilitator Superfamily
HWQ22_RS08055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ22_RS08060	COG3485	protocatechuate 3,4-dioxygenase
HWQ22_RS08065	COG3485	protocatechuate 3,4-dioxygenase
HWQ22_RS08070	COG0710	3-dehydroquinate dehydratase activity
HWQ22_RS08075	COG3420	alginic acid biosynthetic process
HWQ22_RS08080	COG3659	wide pore channel activity
HWQ22_RS08085	COG4993	Dehydrogenase
HWQ22_RS08095	COG2391	methyltransferase activity
HWQ22_RS08110	COG1414	Transcriptional regulator
HWQ22_RS08115	COG0583	DNA-binding transcription factor activity
HWQ22_RS08120	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS08145	COG2814	Major facilitator Superfamily
HWQ22_RS08155	COG0154	amidase activity
HWQ22_RS08175	COG4638	Rieske (2fe-2S)
HWQ22_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS08195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_RS08205	COG3733	amine oxidase
HWQ22_RS08215	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS08225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_RS08230	COG0183	Belongs to the thiolase family
HWQ22_RS08235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_RS08240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_RS08250	COG4829	muconolactone delta-isomerase
HWQ22_RS08255	COG4948	Mandelate Racemase Muconate Lactonizing
HWQ22_RS08260	COG0583	DNA-binding transcription factor activity
HWQ22_RS08270	COG2186	Transcriptional regulator
HWQ22_RS08290	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS08310	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS08320	COG3829	transcription factor binding
HWQ22_RS08330	COG3162	membrane
HWQ22_RS08345	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS08360	COG0753	catalase activity
HWQ22_RS08380	COG1846	Transcriptional regulator
HWQ22_RS08385	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_RS08385	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_RS08395	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWQ22_RS08425	COG1309	transcriptional regulator
HWQ22_RS08435	COG1335	isochorismatase
HWQ22_RS08440	COG0583	DNA-binding transcription factor activity
HWQ22_RS08450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_RS08450	COG0475	glutathione-regulated potassium exporter activity
HWQ22_RS08460	COG1473	amidohydrolase
HWQ22_RS08470	COG2831	hemolysin activation secretion protein
HWQ22_RS08475	COG3210	domain, Protein
HWQ22_RS08505	COG2188	Transcriptional regulator
HWQ22_RS08520	COG0583	DNA-binding transcription factor activity
HWQ22_RS08550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWQ22_RS08570	COG1566	PFAM secretion protein HlyD family protein
HWQ22_RS08585	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS08590	COG0129	dihydroxy-acid dehydratase activity
HWQ22_RS08600	COG0583	DNA-binding transcription factor activity
HWQ22_RS08605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWQ22_RS08615	COG2084	Dehydrogenase
HWQ22_RS08620	COG2207	Transcriptional regulator
HWQ22_RS08635	COG1064	alcohol dehydrogenase
HWQ22_RS08650	COG1120	ATPase activity
HWQ22_RS08670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWQ22_RS08785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HWQ22_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS08850	COG2207	Transcriptional regulator
HWQ22_RS08860	COG2205	protein histidine kinase activity
HWQ22_RS08865	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS08875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ22_RS08880	COG1538	Outer membrane efflux protein
HWQ22_RS08890	COG2072	flavoprotein involved in K transport
HWQ22_RS08910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_RS08930	COG3539	Fimbrial protein
HWQ22_RS08960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWQ22_RS08970	COG0753	catalase activity
HWQ22_RS08985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWQ22_RS09050	COG1535	isochorismatase
HWQ22_RS09050	COG3433	isochorismatase activity
HWQ22_RS09055	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS09060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HWQ22_RS09065	COG4149	molybdate abc transporter
HWQ22_RS09070	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWQ22_RS09080	COG4638	Rieske (2fe-2S)
HWQ22_RS09085	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ22_RS09090	COG0543	2 iron, 2 sulfur cluster binding
HWQ22_RS09090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS09130	COG2207	Transcriptional regulator
HWQ22_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS09145	COG2610	gluconate transmembrane transporter activity
HWQ22_RS09155	COG0583	DNA-binding transcription factor activity
HWQ22_RS09170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_RS09175	COG2031	fatty acid transporter
HWQ22_RS09180	COG0183	Belongs to the thiolase family
HWQ22_RS09185	COG0583	DNA-binding transcription factor activity
HWQ22_RS09190	COG0583	DNA-binding transcription factor activity
HWQ22_RS09205	COG1027	Aspartate ammonia-lyase
HWQ22_RS09215	COG0477	Major facilitator Superfamily
HWQ22_RS09235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_RS09240	COG4521	taurine ABC transporter
HWQ22_RS09255	COG2188	Transcriptional regulator
HWQ22_RS09265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWQ22_RS09270	COG1733	regulation of RNA biosynthetic process
HWQ22_RS09275	COG3708	Transcriptional regulator
HWQ22_RS09275	COG2207	Transcriptional regulator
HWQ22_RS09290	COG0730	response to heat
HWQ22_RS09300	COG3453	Protein conserved in bacteria
HWQ22_RS09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_RS09310	COG3781	membrane
HWQ22_RS09315	COG1063	alcohol dehydrogenase
HWQ22_RS09325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWQ22_RS09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWQ22_RS09335	COG0022	dehydrogenase e1 component
HWQ22_RS09340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWQ22_RS09345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWQ22_RS09360	COG3706	GGDEF domain
HWQ22_RS09375	COG0133	tryptophan synthase activity
HWQ22_RS09385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWQ22_RS09420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWQ22_RS09445	COG2226	methyltransferase
HWQ22_RS09500	COG0842	Transport permease protein
HWQ22_RS09505	COG0842	Transport permease protein
HWQ22_RS09510	COG1131	(ABC) transporter
HWQ22_RS09525	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWQ22_RS09530	COG4773	Receptor
HWQ22_RS09550	COG0730	response to heat
HWQ22_RS09555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWQ22_RS09575	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWQ22_RS09590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWQ22_RS09630	COG4264	IucA IucC family
HWQ22_RS09635	COG4264	IucA IucC family
HWQ22_RS09655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWQ22_RS09670	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS09675	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS09680	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWQ22_RS09685	COG2207	Transcriptional regulator
HWQ22_RS09690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ22_RS09695	COG0776	regulation of translation
HWQ22_RS09720	COG0822	iron-sulfur transferase activity
HWQ22_RS09725	COG0316	Belongs to the HesB IscA family
HWQ22_RS09755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWQ22_RS09775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWQ22_RS09780	COG0702	epimerase
HWQ22_RS09815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWQ22_RS09825	COG0339	signal peptide processing
HWQ22_RS09875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HWQ22_RS09880	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWQ22_RS09910	COG0776	regulation of translation
HWQ22_RS09975	COG0084	hydrolase, TatD family'
HWQ22_RS09995	COG1663	tetraacyldisaccharide 4'-kinase activity
HWQ22_RS10000	COG1132	(ABC) transporter
HWQ22_RS10010	COG0811	peptide transport
HWQ22_RS10015	COG1475	DNA binding
HWQ22_RS10020	COG1192	Involved in chromosome partitioning
HWQ22_RS10030	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWQ22_RS10045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWQ22_RS10050	COG0191	fructose-bisphosphate aldolase activity
HWQ22_RS10070	COG0424	maF-like protein
HWQ22_RS10075	COG2850	peptidyl-arginine hydroxylation
HWQ22_RS10085	COG0640	Transcriptional regulator
HWQ22_RS10100	COG3619	membrane
HWQ22_RS10105	COG3122	Protein conserved in bacteria
HWQ22_RS10110	COG1132	(ABC) transporter
HWQ22_RS10130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWQ22_RS10135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWQ22_RS10145	COG0506	proline dehydrogenase activity
HWQ22_RS10145	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWQ22_RS10145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWQ22_RS10150	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWQ22_RS10165	COG3698	Phosphodiester glycosidase
HWQ22_RS10175	COG2353	YceI-like domain
HWQ22_RS10185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWQ22_RS10230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWQ22_RS10230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HWQ22_RS10255	COG3539	Fimbrial protein
HWQ22_RS10260	COG3121	Chaperone
HWQ22_RS10285	COG0697	spore germination
HWQ22_RS10295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ22_RS10305	COG0583	DNA-binding transcription factor activity
HWQ22_RS10325	COG1309	transcriptional regulator
HWQ22_RS10340	COG1522	sequence-specific DNA binding
HWQ22_RS10350	COG1126	abc transporter atp-binding protein
HWQ22_RS10355	COG0765	amino acid transport
HWQ22_RS10360	COG0765	amino acid transport
HWQ22_RS10390	COG1464	Belongs to the NlpA lipoprotein family
HWQ22_RS10400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWQ22_RS10405	COG2011	ABC-type metal ion transport system permease component
HWQ22_RS10410	COG0012	GTP binding
HWQ22_RS10435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWQ22_RS10475	COG0386	Belongs to the glutathione peroxidase family
HWQ22_RS10485	COG0436	Aminotransferase
HWQ22_RS10525	COG3634	alkyl hydroperoxide reductase activity
HWQ22_RS10540	COG0583	DNA-binding transcription factor activity
HWQ22_RS10545	COG0798	PFAM Bile acid sodium symporter
HWQ22_RS10550	COG0640	Transcriptional regulator
HWQ22_RS10565	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWQ22_RS10575	COG0583	DNA-binding transcription factor activity
HWQ22_RS10585	COG1953	Uracil, thiamine, allantoin
HWQ22_RS10595	COG2175	clavaminate synthase activity
HWQ22_RS10600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_RS10605	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HWQ22_RS10610	COG4521	taurine ABC transporter
HWQ22_RS10625	COG0477	Major facilitator Superfamily
HWQ22_RS10645	COG1271	oxidase subunit
HWQ22_RS10650	COG1294	oxidase, subunit
HWQ22_RS10660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_RS10680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWQ22_RS10700	COG3052	prosthetic group binding
HWQ22_RS10705	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HWQ22_RS10715	COG2814	Major facilitator Superfamily
HWQ22_RS10735	COG1346	cytolysis
HWQ22_RS10745	COG0583	DNA-binding transcription factor activity
HWQ22_RS10750	COG0625	glutathione transferase activity
HWQ22_RS10755	COG0625	glutathione transferase activity
HWQ22_RS10760	COG0583	DNA-binding transcription factor activity
HWQ22_RS10775	COG1045	serine acetyltransferase
HWQ22_RS10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWQ22_RS10785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWQ22_RS10795	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_RS10815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_RS10820	COG1126	abc transporter atp-binding protein
HWQ22_RS10825	COG0765	amino acid transport
HWQ22_RS10830	COG0765	amino acid transport
HWQ22_RS10850	COG2205	protein histidine kinase activity
HWQ22_RS10850	COG0784	Response regulator, receiver
HWQ22_RS10870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWQ22_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS10940	COG0583	DNA-binding transcription factor activity
HWQ22_RS10960	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_RS10965	COG1309	transcriptional regulator
HWQ22_RS10970	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS10975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWQ22_RS10980	COG1024	Enoyl-CoA hydratase
HWQ22_RS10985	COG4770	biotin carboxylase activity
HWQ22_RS10995	COG0583	DNA-binding transcription factor activity
HWQ22_RS11010	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS11020	COG2814	Major facilitator Superfamily
HWQ22_RS11030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWQ22_RS11035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWQ22_RS11040	COG2814	Major facilitator Superfamily
HWQ22_RS11045	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS11050	COG1024	Enoyl-CoA hydratase
HWQ22_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS11060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_RS11065	COG0183	Belongs to the thiolase family
HWQ22_RS11075	COG2814	Major facilitator Superfamily
HWQ22_RS11085	COG1024	Enoyl-CoA hydratase
HWQ22_RS11100	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS11105	COG2814	Major facilitator Superfamily
HWQ22_RS11110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWQ22_RS11115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWQ22_RS11130	COG3842	ATPase activity
HWQ22_RS11135	COG1840	ABC-type Fe3 transport system, periplasmic component
HWQ22_RS11145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_RS11150	COG1414	Transcriptional regulator
HWQ22_RS11160	COG0583	DNA-binding transcription factor activity
HWQ22_RS11165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWQ22_RS11170	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS11180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWQ22_RS11190	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS11195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_RS11200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_RS11205	COG2267	carboxylic ester hydrolase activity
HWQ22_RS11225	COG3038	cytochrome b561
HWQ22_RS11230	COG0753	catalase activity
HWQ22_RS11265	COG2050	protein possibly involved in aromatic compounds catabolism
HWQ22_RS11275	COG3327	negative regulation of DNA-templated transcription, initiation
HWQ22_RS11280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HWQ22_RS11285	COG0183	Belongs to the thiolase family
HWQ22_RS11290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_RS11295	COG1024	Enoyl-CoA hydratase
HWQ22_RS11300	COG1024	Enoyl-CoA hydratase
HWQ22_RS11305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWQ22_RS11310	COG2151	metal-sulfur cluster biosynthetic enzyme
HWQ22_RS11315	COG3396	Phenylacetate-CoA oxygenase
HWQ22_RS11320	COG3460	Phenylacetate-CoA oxygenase
HWQ22_RS11325	COG3396	Phenylacetate-CoA oxygenase
HWQ22_RS11330	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS11330	COG2030	dehydratase
HWQ22_RS11335	COG1760	l-serine dehydratase
HWQ22_RS11340	COG0531	amino acid
HWQ22_RS11345	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS11360	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_RS11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWQ22_RS11390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_RS11400	COG0789	Transcriptional regulator
HWQ22_RS11415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWQ22_RS11430	COG2807	transmembrane transport
HWQ22_RS11435	COG0590	tRNA wobble adenosine to inosine editing
HWQ22_RS11550	COG1116	anion transmembrane transporter activity
HWQ22_RS11555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWQ22_RS11565	COG0864	Transcriptional regulator
HWQ22_RS11585	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWQ22_RS11590	COG0439	Biotin carboxylase
HWQ22_RS11605	COG1063	alcohol dehydrogenase
HWQ22_RS11615	COG1309	transcriptional regulator
HWQ22_RS11635	COG0038	chloride channel
HWQ22_RS11640	COG4770	biotin carboxylase activity
HWQ22_RS11660	COG1914	H( )-stimulated, divalent metal cation uptake system
HWQ22_RS11665	COG0583	DNA-binding transcription factor activity
HWQ22_RS11680	COG3209	COG3209 Rhs family protein
HWQ22_RS11685	COG3501	Rhs element vgr protein
HWQ22_RS11715	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWQ22_RS11735	COG2814	Major facilitator Superfamily
HWQ22_RS11745	COG1560	Kdo2-lipid A biosynthetic process
HWQ22_RS11755	COG5006	permease, DMT superfamily
HWQ22_RS11760	COG1522	sequence-specific DNA binding
HWQ22_RS11775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWQ22_RS11785	COG4122	O-methyltransferase activity
HWQ22_RS11815	COG1538	Outer membrane efflux protein
HWQ22_RS11820	COG1137	ATPase activity
HWQ22_RS11825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HWQ22_RS11835	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HWQ22_RS11840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWQ22_RS11840	COG0517	IMP dehydrogenase activity
HWQ22_RS11875	COG2814	Major facilitator Superfamily
HWQ22_RS11910	COG1278	Cold shock
HWQ22_RS11915	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS11945	COG1570	exodeoxyribonuclease VII activity
HWQ22_RS11995	COG0583	DNA-binding transcription factor activity
HWQ22_RS12000	COG4638	Rieske (2fe-2S)
HWQ22_RS12005	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HWQ22_RS12010	COG0543	2 iron, 2 sulfur cluster binding
HWQ22_RS12010	COG0633	Ferredoxin
HWQ22_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS12020	COG3135	benzoate transporter
HWQ22_RS12025	COG2814	Major facilitator Superfamily
HWQ22_RS12040	COG1643	Atp-dependent helicase
HWQ22_RS12045	COG0450	alkyl hydroperoxide reductase
HWQ22_RS12055	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWQ22_RS12065	COG3634	alkyl hydroperoxide reductase activity
HWQ22_RS12085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWQ22_RS12090	COG0625	glutathione transferase activity
HWQ22_RS12100	COG2885	chlorophyll binding
HWQ22_RS12135	COG0542	response to heat
HWQ22_RS12150	COG1765	OsmC-like protein
HWQ22_RS12165	COG0667	Aldo Keto reductase
HWQ22_RS12180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWQ22_RS12190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWQ22_RS12200	COG0527	aspartate kinase activity
HWQ22_RS12210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWQ22_RS12220	COG3038	cytochrome b561
HWQ22_RS12225	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWQ22_RS12230	COG2252	PERMEase
HWQ22_RS12240	COG2072	flavoprotein involved in K transport
HWQ22_RS12255	COG1741	Belongs to the pirin family
HWQ22_RS12260	COG1309	transcriptional regulator
HWQ22_RS12285	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWQ22_RS12325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_RS12325	COG1902	pentaerythritol trinitrate reductase activity
HWQ22_RS12335	COG2203	Gaf domain
HWQ22_RS12335	COG4251	negative regulation of phosphorylation
HWQ22_RS12335	COG5001	Diguanylate cyclase
HWQ22_RS12335	COG3706	GGDEF domain
HWQ22_RS12345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ22_RS12365	COG4172	Belongs to the ABC transporter superfamily
HWQ22_RS12370	COG4239	(ABC) transporter, permease
HWQ22_RS12375	COG4174	ABC transporter (Permease)
HWQ22_RS12385	COG0741	lytic transglycosylase activity
HWQ22_RS12385	COG1388	LysM domain
HWQ22_RS12385	COG0741	lytic transglycosylase activity
HWQ22_RS12385	COG1388	LysM domain
HWQ22_RS12390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWQ22_RS12430	COG0583	DNA-binding transcription factor activity
HWQ22_RS12435	COG1279	arginine transmembrane transporter activity
HWQ22_RS12455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_RS12460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWQ22_RS12465	COG0006	proline dipeptidase activity
HWQ22_RS12500	COG2194	sulfuric ester hydrolase activity
HWQ22_RS12545	COG0739	heme binding
HWQ22_RS12870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWQ22_RS12895	COG3384	dioxygenase
HWQ22_RS12905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWQ22_RS12910	COG2878	Part of a membrane complex involved in electron transport
HWQ22_RS12915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWQ22_RS12940	COG0768	penicillin binding
HWQ22_RS12945	COG0742	ribosomal rna small subunit methyltransferase
HWQ22_RS12960	COG0830	nickel cation binding
HWQ22_RS12970	COG0804	urea catabolic process
HWQ22_RS13010	COG1253	flavin adenine dinucleotide binding
HWQ22_RS13015	COG2851	Citrate transporter
HWQ22_RS13070	COG1773	rubredoxin
HWQ22_RS13075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWQ22_RS13085	COG0583	DNA-binding transcription factor activity
HWQ22_RS13110	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HWQ22_RS13115	COG4181	ATPase activity
HWQ22_RS13160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWQ22_RS13180	COG0306	phosphate transporter
HWQ22_RS13190	COG3958	Transketolase
HWQ22_RS13195	COG3959	Transketolase, thiamine diphosphate binding domain
HWQ22_RS13200	COG2271	Major facilitator Superfamily
HWQ22_RS13205	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS13210	COG0583	DNA-binding transcription factor activity
HWQ22_RS13225	COG2223	nitrite transmembrane transporter activity
HWQ22_RS13230	COG2207	Transcriptional regulator
HWQ22_RS13235	COG2066	Belongs to the glutaminase family
HWQ22_RS13240	COG0242	peptide deformylase activity
HWQ22_RS13245	COG0477	Major facilitator Superfamily
HWQ22_RS13255	COG0028	Belongs to the TPP enzyme family
HWQ22_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS13275	COG2267	carboxylic ester hydrolase activity
HWQ22_RS13285	COG2271	Major facilitator Superfamily
HWQ22_RS13290	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWQ22_RS13300	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS13320	COG1414	Transcriptional regulator
HWQ22_RS13335	COG1024	Enoyl-CoA hydratase
HWQ22_RS13345	COG1215	transferase activity, transferring glycosyl groups
HWQ22_RS13350	COG0726	polysaccharide deacetylase
HWQ22_RS13350	COG1649	PFAM Uncharacterised BCR, COG1649
HWQ22_RS13360	COG4681	YaeQ
HWQ22_RS13370	COG0523	cobalamin synthesis protein
HWQ22_RS13380	COG1607	acyl-coa hydrolase
HWQ22_RS13390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_RS13395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWQ22_RS13400	COG1309	transcriptional regulator
HWQ22_RS13425	COG2040	homocysteine
HWQ22_RS13430	COG0531	amino acid
HWQ22_RS13485	COG1595	DNA-templated transcription, initiation
HWQ22_RS13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_RS13500	COG0477	Major facilitator Superfamily
HWQ22_RS13520	COG0084	hydrolase, TatD family'
HWQ22_RS13555	COG0629	single-stranded DNA binding
HWQ22_RS13610	COG0582	viral genome integration into host DNA
HWQ22_RS13625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWQ22_RS13750	COG3566	protein conserved in bacteria
HWQ22_RS13765	COG3567	Phage-associated protein, HI1409 family
HWQ22_RS13770	COG5410	chromosome segregation
HWQ22_RS13850	COG4197	protein conserved in bacteria, prophage-related
HWQ22_RS13855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWQ22_RS13920	COG0405	Gamma-glutamyltransferase
HWQ22_RS13925	COG2814	Major facilitator Superfamily
HWQ22_RS13935	COG2050	protein possibly involved in aromatic compounds catabolism
HWQ22_RS13950	COG1090	epimerase
HWQ22_RS13970	COG0420	3'-5' exonuclease activity
HWQ22_RS13995	COG0735	belongs to the Fur family
HWQ22_RS14000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWQ22_RS14020	COG0121	glutamine amidotransferase
HWQ22_RS14035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWQ22_RS14045	COG0210	DNA helicase
HWQ22_RS14050	COG2885	chlorophyll binding
HWQ22_RS14055	COG0204	Acyl-transferase
HWQ22_RS14070	COG2894	cell division
HWQ22_RS14095	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS14100	COG1674	ftsk spoiiie
HWQ22_RS14100	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWQ22_RS14105	COG0492	ferredoxin-NADP+ reductase activity
HWQ22_RS14110	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HWQ22_RS14120	COG0456	acetyltransferase
HWQ22_RS14180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWQ22_RS14180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWQ22_RS14200	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS14220	COG0473	3-isopropylmalate dehydrogenase activity
HWQ22_RS14225	COG0583	DNA-binding transcription factor activity
HWQ22_RS14245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWQ22_RS14270	COG0564	pseudouridine synthase activity
HWQ22_RS14280	COG0358	DNA primase activity
HWQ22_RS14295	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HWQ22_RS14325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWQ22_RS14355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWQ22_RS14365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWQ22_RS14365	COG0352	thiamine-phosphate diphosphorylase activity
HWQ22_RS14365	COG0351	phosphomethylpyrimidine kinase
HWQ22_RS14370	COG1652	LysM domain
HWQ22_RS14395	COG1399	metal-binding, possibly nucleic acid-binding protein
HWQ22_RS14400	COG3101	peptidyl-lysine hydroxylation
HWQ22_RS14405	COG0009	L-threonylcarbamoyladenylate synthase
HWQ22_RS14410	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWQ22_RS14415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWQ22_RS14430	COG4106	trans-aconitate 2-methyltransferase activity
HWQ22_RS14445	COG2226	methyltransferase
HWQ22_RS14445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_RS14445	COG0596	Alpha beta hydrolase
HWQ22_RS14450	COG1877	trehalose-phosphatase activity
HWQ22_RS14455	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HWQ22_RS14460	COG2223	nitrite transmembrane transporter activity
HWQ22_RS14480	COG1196	nuclear chromosome segregation
HWQ22_RS14490	COG0730	response to heat
HWQ22_RS14505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWQ22_RS14515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWQ22_RS14565	COG0489	protein tyrosine kinase activity
HWQ22_RS14575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_RS14575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_RS14605	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWQ22_RS14610	COG2081	HI0933 family
HWQ22_RS14620	COG0668	transmembrane transport
HWQ22_RS14640	COG0583	DNA-binding transcription factor activity
HWQ22_RS14660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWQ22_RS14665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWQ22_RS14695	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWQ22_RS14730	COG2205	protein histidine kinase activity
HWQ22_RS14735	COG0745	RESPONSE REGULATOR receiver
HWQ22_RS14755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWQ22_RS14765	COG2205	protein histidine kinase activity
HWQ22_RS14835	COG4993	Dehydrogenase
HWQ22_RS14860	COG0384	phenazine biosynthesis protein PhzF
HWQ22_RS14875	COG2826	transposase and inactivated derivatives, IS30 family
HWQ22_RS14890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWQ22_RS14905	COG0583	DNA-binding transcription factor activity
HWQ22_RS14925	COG1473	amidohydrolase
HWQ22_RS14935	COG0583	DNA-binding transcription factor activity
HWQ22_RS14950	COG0583	DNA-binding transcription factor activity
HWQ22_RS14955	COG1053	succinate dehydrogenase
HWQ22_RS14965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWQ22_RS14970	COG2814	Major facilitator Superfamily
HWQ22_RS14975	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS14980	COG0583	DNA-binding transcription factor activity
HWQ22_RS14985	COG1063	alcohol dehydrogenase
HWQ22_RS15015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWQ22_RS15020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWQ22_RS15025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ22_RS15040	COG3667	copper resistance
HWQ22_RS15045	COG2132	Multicopper oxidase
HWQ22_RS15055	COG0561	phosphatase activity
HWQ22_RS15060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWQ22_RS15085	COG1214	PFAM Peptidase M22, glycoprotease
HWQ22_RS15140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWQ22_RS15150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWQ22_RS15155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWQ22_RS15160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWQ22_RS15220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWQ22_RS15230	COG1846	Transcriptional regulator
HWQ22_RS15235	COG1764	response to oxidative stress
HWQ22_RS15285	COG0037	tRNA processing
HWQ22_RS15295	COG0248	Ppx GppA phosphatase
HWQ22_RS15325	COG0072	phenylalanine-tRNA ligase activity
HWQ22_RS15365	COG1238	metal cluster binding
HWQ22_RS15370	COG0625	glutathione transferase activity
HWQ22_RS15385	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_RS15390	COG3028	Belongs to the UPF0307 family
HWQ22_RS15395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWQ22_RS15415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWQ22_RS15420	COG0617	tRNA 3'-terminal CCA addition
HWQ22_RS15425	COG1555	photosystem II stabilization
HWQ22_RS15430	COG3956	TIGRFAM MazG family protein
HWQ22_RS15440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWQ22_RS15460	COG2205	protein histidine kinase activity
HWQ22_RS15460	COG0784	Response regulator, receiver
HWQ22_RS15460	COG5002	protein histidine kinase activity
HWQ22_RS15465	COG1024	Enoyl-CoA hydratase
HWQ22_RS15470	COG2084	Dehydrogenase
HWQ22_RS15475	COG3622	Belongs to the hyi family
HWQ22_RS15505	COG0697	spore germination
HWQ22_RS15515	COG2814	Major facilitator Superfamily
HWQ22_RS15520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWQ22_RS15530	COG0583	DNA-binding transcription factor activity
HWQ22_RS15540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWQ22_RS15550	COG0084	hydrolase, TatD family'
HWQ22_RS15565	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HWQ22_RS15595	COG0440	acetolactate synthase activity
HWQ22_RS15600	COG0028	Belongs to the TPP enzyme family
HWQ22_RS15630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWQ22_RS15635	COG0577	efflux transmembrane transporter activity
HWQ22_RS15635	COG1136	(ABC) transporter
HWQ22_RS15640	COG1538	Outer membrane efflux protein
HWQ22_RS15655	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HWQ22_RS15660	COG1162	GTPase activity
HWQ22_RS15670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWQ22_RS15710	COG1426	Protein conserved in bacteria
HWQ22_RS15745	COG0793	Belongs to the peptidase S41A family
HWQ22_RS15770	COG1012	belongs to the aldehyde dehydrogenase family
HWQ22_RS15775	COG3265	gluconokinase activity
HWQ22_RS15785	COG0800	Aldolase
HWQ22_RS15795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWQ22_RS15800	COG0280	phosphate acetyltransferase
HWQ22_RS15800	COG0857	belongs to the CobB CobQ family
HWQ22_RS15805	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HWQ22_RS15805	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HWQ22_RS15825	COG0740	serine-type endopeptidase activity
HWQ22_RS15835	COG4774	siderophore transport
HWQ22_RS15845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWQ22_RS15855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWQ22_RS15855	COG2813	Specifically methylates the guanine in position
HWQ22_RS15955	COG0788	formyltetrahydrofolate deformylase activity
HWQ22_RS15980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_RS15980	COG4651	solute:proton antiporter activity
HWQ22_RS16000	COG0724	RNA recognition motif
HWQ22_RS16005	COG0210	DNA helicase
HWQ22_RS16030	COG1733	regulation of RNA biosynthetic process
HWQ22_RS16040	COG2900	Belongs to the SlyX family
HWQ22_RS16050	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS16055	COG1560	Kdo2-lipid A biosynthetic process
HWQ22_RS16065	COG1301	dicarboxylic acid transport
HWQ22_RS16090	COG0252	asparaginase activity
HWQ22_RS16120	COG0473	3-isopropylmalate dehydrogenase activity
HWQ22_RS16175	COG0583	DNA-binding transcription factor activity
HWQ22_RS16185	COG0625	glutathione transferase activity
HWQ22_RS16190	COG2378	regulation of single-species biofilm formation
HWQ22_RS16195	COG0546	phosphoglycolate phosphatase activity
HWQ22_RS16205	COG1530	ribonuclease E activity
HWQ22_RS16210	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_RS16225	COG0583	DNA-binding transcription factor activity
HWQ22_RS16230	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS16235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWQ22_RS16245	COG0534	Mate efflux family protein
HWQ22_RS16260	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWQ22_RS16300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HWQ22_RS16305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWQ22_RS16320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWQ22_RS16330	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HWQ22_RS16330	COG0644	oxidoreductase
HWQ22_RS16340	COG0425	Belongs to the sulfur carrier protein TusA family
HWQ22_RS16345	COG4535	Mg2 and Co2 transporter CorC
HWQ22_RS16355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWQ22_RS16375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWQ22_RS16380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWQ22_RS16380	COG0475	glutathione-regulated potassium exporter activity
HWQ22_RS16395	COG0484	heat shock protein binding
HWQ22_RS16400	COG0789	Transcriptional regulator
HWQ22_RS16405	COG0598	Magnesium transport protein CorA
HWQ22_RS16425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWQ22_RS16430	COG1074	ATP-dependent DNA helicase activity
HWQ22_RS16435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HWQ22_RS16455	COG2226	methyltransferase
HWQ22_RS16465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWQ22_RS16480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWQ22_RS16495	COG2111	Na H antiporter
HWQ22_RS16495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWQ22_RS16500	COG1006	Multisubunit Na H antiporter MnhC subunit
HWQ22_RS16505	COG0651	ATP synthesis coupled electron transport
HWQ22_RS16515	COG2212	antiporter activity
HWQ22_RS16535	COG0195	Participates in both transcription termination and antitermination
HWQ22_RS16585	COG0237	dephospho-CoA kinase activity
HWQ22_RS16595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWQ22_RS16610	COG0497	DNA recombination
HWQ22_RS16620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWQ22_RS16650	COG2169	Transcriptional regulator
HWQ22_RS16650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWQ22_RS16655	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWQ22_RS16710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWQ22_RS16725	COG0326	Molecular chaperone. Has ATPase activity
HWQ22_RS16740	COG2056	Na+-H+ antiporter family
HWQ22_RS16840	COG0546	phosphoglycolate phosphatase activity
HWQ22_RS16845	COG1716	ATPase activity
HWQ22_RS16890	COG0181	hydroxymethylbilane synthase activity
HWQ22_RS16900	COG3275	phosphorelay sensor kinase activity
HWQ22_RS16925	COG0697	spore germination
HWQ22_RS16950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWQ22_RS16955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWQ22_RS16960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWQ22_RS16965	COG0772	Belongs to the SEDS family
HWQ22_RS16990	COG4974	Belongs to the 'phage' integrase family
HWQ22_RS16995	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_RS17005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWQ22_RS17015	COG2197	response regulator
HWQ22_RS17030	COG0793	Belongs to the peptidase S41A family
HWQ22_RS17035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HWQ22_RS17040	COG0795	lipopolysaccharide-transporting ATPase activity
HWQ22_RS17080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ22_RS17080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWQ22_RS17090	COG0004	ammonium transporteR
HWQ22_RS17095	COG0347	Belongs to the P(II) protein family
HWQ22_RS17105	COG0606	chelatase, subunit chli
HWQ22_RS17115	COG0659	secondary active sulfate transmembrane transporter activity
HWQ22_RS17120	COG0589	response to stress
HWQ22_RS17160	COG0606	chelatase, subunit chli
HWQ22_RS17165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWQ22_RS17175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWQ22_RS17190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWQ22_RS17205	COG0318	PFAM AMP-dependent synthetase and ligase
HWQ22_RS17215	COG0477	Major facilitator Superfamily
HWQ22_RS17220	COG2860	membrane
HWQ22_RS17230	COG1253	flavin adenine dinucleotide binding
HWQ22_RS17240	COG0477	Major facilitator Superfamily
HWQ22_RS17250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWQ22_RS17285	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWQ22_RS17295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWQ22_RS17330	COG1309	transcriptional regulator
HWQ22_RS17365	COG0758	DNA mediated transformation
HWQ22_RS17375	COG0697	spore germination
HWQ22_RS17380	COG1309	transcriptional regulator
HWQ22_RS17395	COG0386	Belongs to the glutathione peroxidase family
HWQ22_RS17460	COG1121	(ABC) transporter
HWQ22_RS17465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWQ22_RS17470	COG1280	lysine exporter protein (LysE YggA)
HWQ22_RS17475	COG2837	iron assimilation
HWQ22_RS17480	COG0281	malic enzyme
HWQ22_RS17525	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWQ22_RS17525	COG0519	Catalyzes the synthesis of GMP from XMP
HWQ22_RS17530	COG4399	Belongs to the UPF0754 family
HWQ22_RS17535	COG2259	Doxx family
HWQ22_RS17540	COG0586	Pfam SNARE associated Golgi protein
HWQ22_RS17555	COG1192	Involved in chromosome partitioning
HWQ22_RS17565	COG0271	Belongs to the BolA IbaG family
HWQ22_RS17605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWQ22_RS17605	COG3321	synthase
HWQ22_RS17605	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWQ22_RS17605	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWQ22_RS17610	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS17620	COG2197	response regulator
HWQ22_RS17630	COG3916	Acyl-homoserine-lactone synthase
HWQ22_RS17635	COG0477	Major facilitator Superfamily
HWQ22_RS17640	COG1024	Enoyl-CoA hydratase
HWQ22_RS17645	COG1024	Enoyl-CoA hydratase
HWQ22_RS17650	COG1960	acyl-CoA dehydrogenase activity
HWQ22_RS17655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWQ22_RS17675	COG1113	amino acid transport
HWQ22_RS17680	COG1113	amino acid transport
HWQ22_RS17685	COG0251	oxidation-reduction process
HWQ22_RS17725	COG0564	pseudouridine synthase activity
HWQ22_RS17770	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWQ22_RS17785	COG1802	Transcriptional regulator
HWQ22_RS17795	COG1448	Aminotransferase
HWQ22_RS17800	COG0277	FAD linked oxidase domain protein
HWQ22_RS17810	COG2186	Transcriptional regulator
HWQ22_RS17820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWQ22_RS17830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWQ22_RS17845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWQ22_RS17850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWQ22_RS17855	COG1216	Glycosyl transferase, family 2
HWQ22_RS17870	COG1215	transferase activity, transferring glycosyl groups
HWQ22_RS17870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWQ22_RS17875	COG1216	Glycosyl transferase, family 2
HWQ22_RS17875	COG1442	glycosyl transferase family 8
HWQ22_RS17885	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HWQ22_RS17890	COG1596	polysaccharide export
HWQ22_RS17915	COG0728	peptidoglycan biosynthetic process
HWQ22_RS17920	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWQ22_RS17975	COG0546	phosphoglycolate phosphatase activity
HWQ22_RS17980	COG1028	Short-chain dehydrogenase reductase Sdr
HWQ22_RS18000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_RS18005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWQ22_RS18010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWQ22_RS18015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWQ22_RS18020	COG1116	anion transmembrane transporter activity
HWQ22_RS18025	COG1309	transcriptional regulator
HWQ22_RS18030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWQ22_RS18040	COG0196	riboflavin kinase activity
HWQ22_RS18045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWQ22_RS18055	COG1047	Peptidyl-prolyl cis-trans
HWQ22_RS18095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWQ22_RS18150	COG2951	lytic endotransglycosylase activity
HWQ22_RS18155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWQ22_RS18170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWQ22_RS18180	COG0671	phosphoesterase, PA-phosphatase related
HWQ22_RS18185	COG0861	Integral membrane protein TerC family
HWQ22_RS18195	COG0754	glutathionylspermidine amidase activity
HWQ22_RS18205	COG0402	S-adenosylhomocysteine deaminase activity
HWQ22_RS18220	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWQ22_RS18225	COG1230	cation diffusion facilitator family transporter
HWQ22_RS18240	COG0706	membrane insertase activity