locus-tag	class	description
H5029_RS00010	COG0592	DNA-directed DNA polymerase activity
H5029_RS00020	COG0187	DNA topoisomerase II activity
H5029_RS00030	COG0586	Pfam SNARE associated Golgi protein
H5029_RS00035	COG0488	(ABC) transporter
H5029_RS00060	COG0596	Alpha beta hydrolase
H5029_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H5029_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H5029_RS00110	COG0733	neurotransmitter:sodium symporter activity
H5029_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H5029_RS00145	COG0583	DNA-binding transcription factor activity
H5029_RS00150	COG2233	PERMEase
H5029_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS00200	COG2814	Major facilitator Superfamily
H5029_RS00205	COG0656	L-ascorbic acid biosynthetic process
H5029_RS00210	COG0583	DNA-binding transcription factor activity
H5029_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_RS00230	COG1064	alcohol dehydrogenase
H5029_RS00235	COG2818	Glycosylase
H5029_RS00250	COG1194	a g-specific adenine glycosylase
H5029_RS00270	COG2983	Belongs to the UPF0260 family
H5029_RS00275	COG2133	pyrroloquinoline quinone binding
H5029_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5029_RS00285	COG2116	formate transmembrane transporter activity
H5029_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_RS00310	COG1335	isochorismatase
H5029_RS00315	COG0385	Bile acid
H5029_RS00320	COG0534	Mate efflux family protein
H5029_RS00325	COG1683	Conserved Protein
H5029_RS00345	COG0625	glutathione transferase activity
H5029_RS00355	COG1113	amino acid transport
H5029_RS00365	COG0523	cobalamin synthesis protein
H5029_RS00375	COG2188	Transcriptional regulator
H5029_RS00405	COG0010	Belongs to the arginase family
H5029_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5029_RS00440	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H5029_RS00445	COG0732	type I restriction modification DNA specificity domain
H5029_RS00475	COG4584	PFAM Integrase catalytic
H5029_RS00505	COG2826	transposase and inactivated derivatives, IS30 family
H5029_RS00525	COG0673	inositol 2-dehydrogenase activity
H5029_RS00530	COG1324	tolerance protein
H5029_RS00575	COG2826	transposase and inactivated derivatives, IS30 family
H5029_RS00580	COG2015	COG2015, Alkyl sulfatase and related hydrolases
H5029_RS00590	COG2826	transposase and inactivated derivatives, IS30 family
H5029_RS00640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5029_RS00650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H5029_RS00655	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5029_RS00755	COG0534	Mate efflux family protein
H5029_RS00760	COG0436	Aminotransferase
H5029_RS00765	COG2733	membrane
H5029_RS00780	COG2918	glutathione biosynthetic process
H5029_RS00795	COG1388	LysM domain
H5029_RS00795	COG0791	NLP P60 protein
H5029_RS00810	COG3150	esterase
H5029_RS00820	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS00825	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
H5029_RS00835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_RS00845	COG2233	PERMEase
H5029_RS00850	COG2351	hydroxyisourate hydrolase activity
H5029_RS00885	COG3706	GGDEF domain
H5029_RS00900	COG1393	Belongs to the ArsC family
H5029_RS00905	COG0708	Exodeoxyribonuclease III
H5029_RS00925	COG0189	ligase activity
H5029_RS00945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H5029_RS00955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5029_RS00970	COG4942	peptidase
H5029_RS00980	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5029_RS00990	COG2119	membrane
H5029_RS00995	COG4774	siderophore transport
H5029_RS01000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_RS01000	COG0426	domain, Protein
H5029_RS01025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H5029_RS01045	COG1902	pentaerythritol trinitrate reductase activity
H5029_RS01050	COG1519	Transferase
H5029_RS01055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5029_RS01060	COG0668	transmembrane transport
H5029_RS01070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_RS01075	COG1335	isochorismatase
H5029_RS01080	COG1522	sequence-specific DNA binding
H5029_RS01110	COG0784	Response regulator, receiver
H5029_RS01110	COG2198	Histidine kinase
H5029_RS01110	COG2205	protein histidine kinase activity
H5029_RS01115	COG3162	membrane
H5029_RS01120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5029_RS01130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_RS01150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5029_RS01155	COG1309	transcriptional regulator
H5029_RS01175	COG0351	phosphomethylpyrimidine kinase
H5029_RS01175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5029_RS01175	COG0352	thiamine-phosphate diphosphorylase activity
H5029_RS01185	COG2814	Major facilitator Superfamily
H5029_RS01200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5029_RS01210	COG1113	amino acid transport
H5029_RS01220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5029_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS01235	COG1335	isochorismatase
H5029_RS01265	COG2814	Major facilitator Superfamily
H5029_RS01270	COG0583	DNA-binding transcription factor activity
H5029_RS01290	COG0667	Aldo Keto reductase
H5029_RS01325	COG1733	regulation of RNA biosynthetic process
H5029_RS01330	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_RS01405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
H5029_RS01420	COG2329	Antibiotic biosynthesis monooxygenase
H5029_RS01450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H5029_RS01480	COG0427	acetyl-CoA hydrolase
H5029_RS01505	COG0659	secondary active sulfate transmembrane transporter activity
H5029_RS01510	COG4221	oxidoreductase activity
H5029_RS01515	COG2873	o-acetylhomoserine
H5029_RS01520	COG0488	(ABC) transporter
H5029_RS01605	COG0833	amino acid
H5029_RS01650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5029_RS01655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H5029_RS01670	COG2226	methyltransferase
H5029_RS01720	COG0067	glutamate synthase
H5029_RS01720	COG0070	glutamate synthase
H5029_RS01720	COG0069	glutamate synthase activity
H5029_RS01725	COG0493	'glutamate synthase
H5029_RS01735	COG1704	LemA family
H5029_RS01740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H5029_RS01760	COG3307	-O-antigen
H5029_RS01780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5029_RS01795	COG0194	GDP metabolic process
H5029_RS01845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H5029_RS01865	COG5380	lipid catabolic process
H5029_RS01870	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H5029_RS01895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5029_RS01900	COG0277	FAD linked oxidase domain protein
H5029_RS01910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
H5029_RS01915	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_RS01930	COG1289	transmembrane transporter activity
H5029_RS01940	COG0628	permease
H5029_RS01945	COG1192	Involved in chromosome partitioning
H5029_RS01975	COG0833	amino acid
H5029_RS01980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5029_RS01985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5029_RS01995	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS02035	COG0583	DNA-binding transcription factor activity
H5029_RS02080	COG0517	IMP dehydrogenase activity
H5029_RS02085	COG1983	PspC domain protein
H5029_RS02095	COG1960	acyl-CoA dehydrogenase activity
H5029_RS02110	COG0408	coproporphyrinogen oxidase activity
H5029_RS02130	COG0513	Belongs to the DEAD box helicase family
H5029_RS02140	COG1127	ABC transporter
H5029_RS02145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5029_RS02155	COG2854	intermembrane phospholipid transfer
H5029_RS02165	COG0598	Magnesium transport protein CorA
H5029_RS02175	COG0494	nUDIX hydrolase
H5029_RS02180	COG1040	competence protein
H5029_RS02185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5029_RS02205	COG1946	Acyl-CoA thioesterase
H5029_RS02210	COG1301	dicarboxylic acid transport
H5029_RS02225	COG1959	2 iron, 2 sulfur cluster binding
H5029_RS02230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_RS02230	COG1017	nitric oxide dioxygenase activity
H5029_RS02235	COG0433	COG0433 Predicted ATPase
H5029_RS02240	COG0626	cystathionine gamma-synthase activity
H5029_RS02395	COG1960	acyl-CoA dehydrogenase activity
H5029_RS02400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H5029_RS02430	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
H5029_RS02435	COG0339	signal peptide processing
H5029_RS02440	COG0557	exoribonuclease II activity
H5029_RS02485	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5029_RS02490	COG2169	Transcriptional regulator
H5029_RS02495	COG0697	spore germination
H5029_RS02500	COG1295	ribonuclease BN
H5029_RS02535	COG1702	phosphate starvation-inducible protein PhoH
H5029_RS02545	COG0739	heme binding
H5029_RS02545	COG0741	lytic transglycosylase activity
H5029_RS02545	COG1196	nuclear chromosome segregation
H5029_RS02575	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H5029_RS02580	COG1183	phosphatidylcholine synthase activity
H5029_RS02625	COG1960	acyl-CoA dehydrogenase activity
H5029_RS02630	COG1309	transcriptional regulator
H5029_RS02645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5029_RS02650	COG1960	acyl-CoA dehydrogenase activity
H5029_RS02670	COG2969	positive regulation of protein catabolic process
H5029_RS02680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5029_RS02695	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H5029_RS02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H5029_RS02720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H5029_RS02730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5029_RS02735	COG1408	metallophosphoesterase
H5029_RS02840	COG1607	acyl-coa hydrolase
H5029_RS02870	COG2350	Protein conserved in bacteria
H5029_RS02880	COG0613	PHP domain protein
H5029_RS02885	COG3781	membrane
H5029_RS02895	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H5029_RS02900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5029_RS02910	COG1862	Preprotein translocase
H5029_RS02940	COG2205	protein histidine kinase activity
H5029_RS02945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H5029_RS02965	COG0726	polysaccharide deacetylase
H5029_RS02970	COG0463	Glycosyl transferase, family 2
H5029_RS02975	COG0438	transferase activity, transferring glycosyl groups
H5029_RS03040	COG0625	glutathione transferase activity
H5029_RS03045	COG0583	DNA-binding transcription factor activity
H5029_RS03050	COG1960	acyl-CoA dehydrogenase activity
H5029_RS03055	COG1960	acyl-CoA dehydrogenase activity
H5029_RS03065	COG2205	protein histidine kinase activity
H5029_RS03070	COG0745	RESPONSE REGULATOR receiver
H5029_RS03075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H5029_RS03095	COG2096	Adenosyltransferase
H5029_RS03145	COG0285	dihydrofolate synthase activity
H5029_RS03165	COG0450	alkyl hydroperoxide reductase
H5029_RS03180	COG0477	Major facilitator Superfamily
H5029_RS03185	COG1272	protein, Hemolysin III
H5029_RS03215	COG0183	Belongs to the thiolase family
H5029_RS03220	COG2207	Transcriptional regulator
H5029_RS03240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_RS03260	COG0183	Belongs to the thiolase family
H5029_RS03270	COG2885	chlorophyll binding
H5029_RS03270	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H5029_RS03280	COG1690	Belongs to the RtcB family
H5029_RS03285	COG0833	amino acid
H5029_RS03295	COG2233	PERMEase
H5029_RS03300	COG1217	gtp-binding protein TYPA
H5029_RS03325	COG2094	Belongs to the DNA glycosylase MPG family
H5029_RS03330	COG4772	TonB-dependent receptor
H5029_RS03345	COG1902	pentaerythritol trinitrate reductase activity
H5029_RS03350	COG0679	Auxin Efflux Carrier
H5029_RS03360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_RS03365	COG0354	folic acid binding
H5029_RS03375	COG3189	MarR family transcriptional regulator
H5029_RS03380	COG2824	Alkylphosphonate utilization operon protein PhnA
H5029_RS03385	COG3422	double-strand break repair
H5029_RS03425	COG0840	transmembrane signaling receptor activity
H5029_RS03445	COG5510	response to toxic substance
H5029_RS03455	COG2832	Protein of unknown function (DUF454)
H5029_RS03460	COG1376	ErfK ybiS ycfS ynhG family protein
H5029_RS03500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H5029_RS03510	COG1289	transmembrane transporter activity
H5029_RS03515	COG2814	Major facilitator Superfamily
H5029_RS03535	COG1115	amino acid carrier protein
H5029_RS03540	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5029_RS03545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5029_RS03550	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H5029_RS03590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5029_RS03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5029_RS03605	COG1077	Cell shape determining protein MreB Mrl
H5029_RS03610	COG1792	Involved in formation and maintenance of cell shape
H5029_RS03615	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H5029_RS03620	COG0424	maF-like protein
H5029_RS03625	COG1530	ribonuclease E activity
H5029_RS03635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_RS03645	COG0560	Phosphoserine phosphatase
H5029_RS03655	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_RS03680	COG2207	Transcriptional regulator
H5029_RS03700	COG1113	amino acid transport
H5029_RS03705	COG2828	Protein conserved in bacteria
H5029_RS03710	COG0142	geranyltranstransferase activity
H5029_RS03715	COG2315	Protein conserved in bacteria
H5029_RS03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
H5029_RS03750	COG2194	sulfuric ester hydrolase activity
H5029_RS03755	COG0745	RESPONSE REGULATOR receiver
H5029_RS03760	COG0642	Histidine kinase
H5029_RS03770	COG0004	ammonium transporteR
H5029_RS03775	COG0583	DNA-binding transcription factor activity
H5029_RS03795	COG0525	valine-tRNA ligase activity
H5029_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS03815	COG0393	Putative heavy-metal-binding
H5029_RS03820	COG0393	Putative heavy-metal-binding
H5029_RS03825	COG1538	Outer membrane efflux protein
H5029_RS03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS03840	COG0671	phosphoesterase, PA-phosphatase related
H5029_RS03870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5029_RS03885	COG1648	precorrin-2 dehydrogenase activity
H5029_RS03885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H5029_RS03890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5029_RS03895	COG1733	regulation of RNA biosynthetic process
H5029_RS03905	COG0531	amino acid
H5029_RS03920	COG0321	lipoyl(octanoyl) transferase activity
H5029_RS03925	COG2921	Belongs to the UPF0250 family
H5029_RS03970	COG2009	succinate dehydrogenase
H5029_RS03975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H5029_RS03980	COG1053	succinate dehydrogenase
H5029_RS03985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5029_RS04010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_RS04030	COG2354	Protein conserved in bacteria
H5029_RS04035	COG2321	neutral zinc metallopeptidase
H5029_RS04075	COG2843	Capsule synthesis protein
H5029_RS04090	COG0589	response to stress
H5029_RS04110	COG0505	Belongs to the CarA family
H5029_RS04135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5029_RS04140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5029_RS04190	COG0477	Major facilitator Superfamily
H5029_RS04195	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H5029_RS04210	COG1597	lipid kinase activity
H5029_RS04215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5029_RS04225	COG2826	transposase and inactivated derivatives, IS30 family
H5029_RS04255	COG0584	glycerophosphoryl diester phosphodiesterase
H5029_RS04275	COG0741	lytic transglycosylase activity
H5029_RS04295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H5029_RS04310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_RS04335	COG0778	Nitroreductase
H5029_RS04350	COG1929	Belongs to the glycerate kinase type-1 family
H5029_RS04355	COG0243	molybdopterin cofactor binding
H5029_RS04360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5029_RS04365	COG3339	Conserved Protein
H5029_RS04375	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H5029_RS04390	COG1113	amino acid transport
H5029_RS04400	COG0019	diaminopimelate decarboxylase activity
H5029_RS04410	COG1280	lysine exporter protein (LysE YggA)
H5029_RS04415	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H5029_RS04445	COG0463	Glycosyl transferase, family 2
H5029_RS04465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS04500	COG4591	ABC-type transport system involved in lipoprotein release permease component
H5029_RS04505	COG1136	(ABC) transporter
H5029_RS04510	COG0658	competence protein
H5029_RS04510	COG2333	competence protein COMEC
H5029_RS04520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5029_RS04520	COG0616	signal peptide processing
H5029_RS04525	COG0596	Alpha beta hydrolase
H5029_RS04530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5029_RS04540	COG0628	permease
H5029_RS04575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5029_RS04595	COG0823	Involved in the tonB-independent uptake of proteins
H5029_RS04615	COG0824	Thioesterase
H5029_RS04620	COG1473	amidohydrolase
H5029_RS04640	COG0047	phosphoribosylformylglycinamidine synthase activity
H5029_RS04640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5029_RS04645	COG2814	Major facilitator Superfamily
H5029_RS04655	COG1024	Enoyl-CoA hydratase
H5029_RS04660	COG1051	belongs to the nudix hydrolase family
H5029_RS04660	COG1056	cytidyltransferase-related domain
H5029_RS04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5029_RS04685	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5029_RS04700	COG4625	pathogenesis
H5029_RS04710	COG0583	DNA-binding transcription factor activity
H5029_RS04715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H5029_RS04720	COG4208	sulfate ABC transporter
H5029_RS04725	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H5029_RS04735	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H5029_RS04740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H5029_RS04745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H5029_RS04765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5029_RS04780	COG0681	Belongs to the peptidase S26 family
H5029_RS04795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5029_RS04805	COG1381	Involved in DNA repair and RecF pathway recombination
H5029_RS04810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H5029_RS04820	COG4221	oxidoreductase activity
H5029_RS04850	COG0436	Aminotransferase
H5029_RS04870	COG0556	nucleotide-excision repair
H5029_RS04925	COG2070	2-Nitropropane dioxygenase
H5029_RS04955	COG1215	transferase activity, transferring glycosyl groups
H5029_RS04970	COG0415	Belongs to the DNA photolyase family
H5029_RS04980	COG1252	NADH dehydrogenase
H5029_RS04985	COG1686	Belongs to the peptidase S11 family
H5029_RS05000	COG1187	pseudouridine synthase activity
H5029_RS05025	COG0477	Major facilitator Superfamily
H5029_RS05030	COG0583	DNA-binding transcription factor activity
H5029_RS05035	COG1823	symporter activity
H5029_RS05045	COG0612	Peptidase, M16
H5029_RS05070	COG0352	thiamine-phosphate diphosphorylase activity
H5029_RS05105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_RS05120	COG1309	transcriptional regulator
H5029_RS05130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H5029_RS05135	COG0076	glutamate decarboxylase activity
H5029_RS05145	COG1522	sequence-specific DNA binding
H5029_RS05150	COG3961	Belongs to the TPP enzyme family
H5029_RS05155	COG1113	amino acid transport
H5029_RS05160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5029_RS05165	COG0573	inorganic phosphate transmembrane transporter activity
H5029_RS05175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H5029_RS05180	COG0616	signal peptide processing
H5029_RS05190	COG3328	transposase activity
H5029_RS05220	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H5029_RS05225	COG1686	Belongs to the peptidase S11 family
H5029_RS05250	COG0583	DNA-binding transcription factor activity
H5029_RS05255	COG1067	ATP-dependent peptidase activity
H5029_RS05300	COG1966	Carbon starvation protein
H5029_RS05305	COG2879	small protein
H5029_RS05335	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H5029_RS05335	COG2508	Transcriptional regulator
H5029_RS05355	COG1113	amino acid transport
H5029_RS05365	COG0583	DNA-binding transcription factor activity
H5029_RS05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_RS05375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_RS05385	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS05390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_RS05395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5029_RS05395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_RS05430	COG2814	Major facilitator Superfamily
H5029_RS05435	COG4948	Mandelate Racemase Muconate Lactonizing
H5029_RS05445	COG1309	transcriptional regulator
H5029_RS05465	COG1741	Belongs to the pirin family
H5029_RS05475	COG2964	Protein conserved in bacteria
H5029_RS05490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_RS05495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5029_RS05500	COG4605	iron ion homeostasis
H5029_RS05505	COG4604	ABC transporter, ATP-binding protein
H5029_RS05510	COG4607	ABC-type enterochelin transport system periplasmic component
H5029_RS05515	COG4774	siderophore transport
H5029_RS05525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H5029_RS05530	COG1021	2,3-dihydroxybenzoate-AMP ligase
H5029_RS05535	COG1535	isochorismatase
H5029_RS05535	COG3433	isochorismatase activity
H5029_RS05550	COG1132	(ABC) transporter
H5029_RS05555	COG1132	(ABC) transporter
H5029_RS05560	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
H5029_RS05570	COG1169	isochorismate synthase
H5029_RS05585	COG3739	integral membrane protein
H5029_RS05610	COG0302	gtp cyclohydrolase
H5029_RS05620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H5029_RS05650	COG0308	aminopeptidase N
H5029_RS05655	COG0512	Glutamine amidotransferase of anthranilate synthase
H5029_RS05670	COG0174	glutamine synthetase
H5029_RS05680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H5029_RS05715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5029_RS05720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5029_RS05725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5029_RS05745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5029_RS05750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H5029_RS05755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H5029_RS05770	COG1960	acyl-CoA dehydrogenase activity
H5029_RS05775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5029_RS05780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_RS05790	COG2223	nitrite transmembrane transporter activity
H5029_RS05800	COG0024	Methionine aminopeptidase
H5029_RS05805	COG0052	Belongs to the universal ribosomal protein uS2 family
H5029_RS05820	COG2207	Transcriptional regulator
H5029_RS05845	COG2951	lytic endotransglycosylase activity
H5029_RS05850	COG0772	Belongs to the SEDS family
H5029_RS05865	COG0842	Transport permease protein
H5029_RS05870	COG1131	(ABC) transporter
H5029_RS05915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS05930	COG4215	(ABC) transporter
H5029_RS05935	COG4160	amino acid transport
H5029_RS05940	COG4598	ABC transporter
H5029_RS05950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_RS05955	COG0826	peptidase U32
H5029_RS05960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_RS05975	COG1720	tRNA m6t6A37 methyltransferase activity
H5029_RS05985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5029_RS06000	COG0642	Histidine kinase
H5029_RS06010	COG0494	nUDIX hydrolase
H5029_RS06020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H5029_RS06025	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5029_RS06030	COG3139	Protein of unknown function (DUF1315)
H5029_RS06035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5029_RS06040	COG1301	dicarboxylic acid transport
H5029_RS06045	COG1960	acyl-CoA dehydrogenase activity
H5029_RS06050	COG2819	hydrolase of the alpha beta superfamily
H5029_RS06060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5029_RS06070	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5029_RS06075	COG1234	tRNA 3'-trailer cleavage
H5029_RS06105	COG2363	Small membrane protein
H5029_RS06125	COG0513	Belongs to the DEAD box helicase family
H5029_RS06135	COG0778	Nitroreductase
H5029_RS06165	COG1286	toxin biosynthetic process
H5029_RS06190	COG4783	chaperone-mediated protein folding
H5029_RS06195	COG1610	YqeY-like protein
H5029_RS06295	COG3111	PFAM Bacterial OB fold (BOF) protein
H5029_RS06320	COG3243	poly(R)-hydroxyalkanoic acid synthase
H5029_RS06325	COG0786	glutamate:sodium symporter activity
H5029_RS06335	COG2186	Transcriptional regulator
H5029_RS06385	COG0477	Major facilitator Superfamily
H5029_RS06410	COG2985	domain, Protein
H5029_RS06420	COG2995	paraquat-inducible protein a
H5029_RS06425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5029_RS06425	COG3008	intermembrane lipid transfer
H5029_RS06435	COG1794	racemase activity, acting on amino acids and derivatives
H5029_RS06525	COG0482	sulfurtransferase activity
H5029_RS06540	COG0488	(ABC) transporter
H5029_RS06545	COG3173	Aminoglycoside phosphotransferase
H5029_RS06555	COG2433	Pfam Transposase IS66
H5029_RS06595	COG1301	dicarboxylic acid transport
H5029_RS06605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_RS06610	COG2011	ABC-type metal ion transport system permease component
H5029_RS06615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5029_RS06620	COG1464	Belongs to the NlpA lipoprotein family
H5029_RS06625	COG0151	Belongs to the GarS family
H5029_RS06630	COG0138	bifunctional purine biosynthesis protein purh
H5029_RS06635	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H5029_RS06665	COG2308	Evidence 4 Homologs of previously reported genes of
H5029_RS06675	COG1305	Transglutaminase-like
H5029_RS06685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5029_RS06690	COG0305	Participates in initiation and elongation during chromosome replication
H5029_RS06715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H5029_RS06725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H5029_RS06730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H5029_RS06755	COG0726	polysaccharide deacetylase
H5029_RS06755	COG1649	PFAM Uncharacterised BCR, COG1649
H5029_RS06760	COG1215	transferase activity, transferring glycosyl groups
H5029_RS06765	COG3658	cytochrome
H5029_RS06775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_RS06790	COG0583	DNA-binding transcription factor activity
H5029_RS06810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_RS06815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_RS06830	COG1960	acyl-CoA dehydrogenase activity
H5029_RS06835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_RS06840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_RS06865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H5029_RS06870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5029_RS06880	COG2205	protein histidine kinase activity
H5029_RS06885	COG0745	RESPONSE REGULATOR receiver
H5029_RS06890	COG0174	glutamine synthetase
H5029_RS06910	COG0729	surface antigen
H5029_RS06935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5029_RS06940	COG2814	Major facilitator Superfamily
H5029_RS06955	COG0583	DNA-binding transcription factor activity
H5029_RS06970	COG1187	pseudouridine synthase activity
H5029_RS06990	COG0802	atpase or kinase
H5029_RS06995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H5029_RS07005	COG1923	regulation of RNA biosynthetic process
H5029_RS07010	COG0697	spore germination
H5029_RS07025	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_RS07035	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5029_RS07040	COG0519	Catalyzes the synthesis of GMP from XMP
H5029_RS07040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5029_RS07045	COG4302	ethanolamine ammonia-lyase activity
H5029_RS07050	COG4303	Ethanolamine ammonia lyase large subunit
H5029_RS07055	COG0531	amino acid
H5029_RS07075	COG1454	alcohol dehydrogenase
H5029_RS07080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5029_RS07090	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
H5029_RS07110	COG0308	aminopeptidase N
H5029_RS07140	COG1605	Chorismate mutase
H5029_RS07155	COG1309	transcriptional regulator
H5029_RS07165	COG0668	transmembrane transport
H5029_RS07205	COG4773	Receptor
H5029_RS07225	COG0488	(ABC) transporter
H5029_RS07230	COG0589	response to stress
H5029_RS07255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H5029_RS07265	COG3135	benzoate transporter
H5029_RS07270	COG1522	sequence-specific DNA binding
H5029_RS07280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H5029_RS07285	COG0583	DNA-binding transcription factor activity
H5029_RS07295	COG0183	Belongs to the thiolase family
H5029_RS07305	COG2030	dehydratase
H5029_RS07310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5029_RS07325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5029_RS07335	COG0824	Thioesterase
H5029_RS07340	COG1454	alcohol dehydrogenase
H5029_RS07350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5029_RS07370	COG0069	glutamate synthase activity
H5029_RS07390	COG2814	Major facilitator Superfamily
H5029_RS07405	COG0511	ligase activity, forming carbon-carbon bonds
H5029_RS07425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_RS07425	COG1116	anion transmembrane transporter activity
H5029_RS07430	COG0745	RESPONSE REGULATOR receiver
H5029_RS07440	COG2146	nitrite reductase [NAD(P)H] activity
H5029_RS07440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_RS07445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_RS07450	COG0243	molybdopterin cofactor binding
H5029_RS07460	COG0243	molybdopterin cofactor binding
H5029_RS07465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5029_RS07480	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5029_RS07480	COG0315	cyclic pyranopterin monophosphate synthase activity
H5029_RS07485	COG0303	'Molybdopterin
H5029_RS07495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_RS07500	COG0697	spore germination
H5029_RS07520	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
H5029_RS07525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5029_RS07580	COG2204	response regulator
H5029_RS07585	COG3852	Histidine kinase
H5029_RS07605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H5029_RS07610	COG0575	Belongs to the CDS family
H5029_RS07645	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_RS07660	COG2137	regulation of response to DNA damage stimulus
H5029_RS07670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5029_RS07675	COG1011	Hydrolase
H5029_RS07700	COG1522	sequence-specific DNA binding
H5029_RS07710	COG1113	amino acid transport
H5029_RS07725	COG0659	secondary active sulfate transmembrane transporter activity
H5029_RS07730	COG2135	peptidase activity
H5029_RS07745	COG5001	Diguanylate cyclase
H5029_RS07745	COG3300	MHYT domain
H5029_RS07765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5029_RS07765	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
H5029_RS07765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H5029_RS07770	COG1105	Belongs to the carbohydrate kinase PfkB family
H5029_RS07775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H5029_RS07775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5029_RS07805	COG0024	Methionine aminopeptidase
H5029_RS07810	COG0583	DNA-binding transcription factor activity
H5029_RS07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H5029_RS07825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5029_RS07830	COG0517	IMP dehydrogenase activity
H5029_RS07830	COG0516	GMP reductase activity
H5029_RS07855	COG0552	protein localization to endoplasmic reticulum
H5029_RS07865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
H5029_RS07880	COG4890	Cyd operon protein YbgT
H5029_RS07885	COG1294	oxidase, subunit
H5029_RS07900	COG1585	Membrane protein implicated in regulation of membrane protease activity
H5029_RS07910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H5029_RS07915	COG4774	siderophore transport
H5029_RS07930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5029_RS07935	COG0569	domain protein
H5029_RS07940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5029_RS07970	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5029_RS07975	COG0542	response to heat
H5029_RS08000	COG1902	pentaerythritol trinitrate reductase activity
H5029_RS08000	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_RS08045	COG2323	membrane
H5029_RS08050	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H5029_RS08060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_RS08065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_RS08070	COG0183	Belongs to the thiolase family
H5029_RS08075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5029_RS08080	COG0596	Alpha beta hydrolase
H5029_RS08085	COG2271	Major facilitator Superfamily
H5029_RS08090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5029_RS08095	COG3485	protocatechuate 3,4-dioxygenase
H5029_RS08100	COG3485	protocatechuate 3,4-dioxygenase
H5029_RS08105	COG0710	3-dehydroquinate dehydratase activity
H5029_RS08110	COG3420	alginic acid biosynthetic process
H5029_RS08115	COG3659	wide pore channel activity
H5029_RS08120	COG4993	Dehydrogenase
H5029_RS08130	COG2391	methyltransferase activity
H5029_RS08145	COG1414	Transcriptional regulator
H5029_RS08150	COG0583	DNA-binding transcription factor activity
H5029_RS08155	COG1960	acyl-CoA dehydrogenase activity
H5029_RS08180	COG2814	Major facilitator Superfamily
H5029_RS08190	COG0154	amidase activity
H5029_RS08210	COG4638	Rieske (2fe-2S)
H5029_RS08220	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS08230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_RS08240	COG3733	amine oxidase
H5029_RS08250	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_RS08265	COG0183	Belongs to the thiolase family
H5029_RS08270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_RS08275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_RS08285	COG4829	muconolactone delta-isomerase
H5029_RS08290	COG4948	Mandelate Racemase Muconate Lactonizing
H5029_RS08295	COG0583	DNA-binding transcription factor activity
H5029_RS08305	COG2186	Transcriptional regulator
H5029_RS08325	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS08345	COG1960	acyl-CoA dehydrogenase activity
H5029_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS08355	COG3829	transcription factor binding
H5029_RS08365	COG3162	membrane
H5029_RS08380	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS08395	COG0753	catalase activity
H5029_RS08415	COG1846	Transcriptional regulator
H5029_RS08420	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_RS08420	COG1902	pentaerythritol trinitrate reductase activity
H5029_RS08430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H5029_RS08460	COG1309	transcriptional regulator
H5029_RS08470	COG1335	isochorismatase
H5029_RS08475	COG0583	DNA-binding transcription factor activity
H5029_RS08485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_RS08485	COG0475	glutathione-regulated potassium exporter activity
H5029_RS08495	COG1473	amidohydrolase
H5029_RS08505	COG2831	hemolysin activation secretion protein
H5029_RS08510	COG3210	domain, Protein
H5029_RS08540	COG2188	Transcriptional regulator
H5029_RS08555	COG0583	DNA-binding transcription factor activity
H5029_RS08585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5029_RS08605	COG1566	PFAM secretion protein HlyD family protein
H5029_RS08620	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS08625	COG0129	dihydroxy-acid dehydratase activity
H5029_RS08635	COG0583	DNA-binding transcription factor activity
H5029_RS08640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5029_RS08650	COG2084	Dehydrogenase
H5029_RS08655	COG2207	Transcriptional regulator
H5029_RS08670	COG1064	alcohol dehydrogenase
H5029_RS08680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5029_RS08685	COG1120	ATPase activity
H5029_RS08705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5029_RS08820	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H5029_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS08885	COG2207	Transcriptional regulator
H5029_RS08895	COG2205	protein histidine kinase activity
H5029_RS08900	COG0745	RESPONSE REGULATOR receiver
H5029_RS08905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS08910	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5029_RS08915	COG1538	Outer membrane efflux protein
H5029_RS08925	COG2072	flavoprotein involved in K transport
H5029_RS08945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_RS08965	COG3539	Fimbrial protein
H5029_RS08995	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H5029_RS09005	COG0753	catalase activity
H5029_RS09020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H5029_RS09080	COG3433	isochorismatase activity
H5029_RS09080	COG1535	isochorismatase
H5029_RS09085	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS09090	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H5029_RS09095	COG4149	molybdate abc transporter
H5029_RS09100	COG0725	ABC transporter, periplasmic molybdate-binding protein
H5029_RS09110	COG4638	Rieske (2fe-2S)
H5029_RS09115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5029_RS09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_RS09120	COG0543	2 iron, 2 sulfur cluster binding
H5029_RS09145	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS09160	COG2207	Transcriptional regulator
H5029_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS09175	COG2610	gluconate transmembrane transporter activity
H5029_RS09185	COG0583	DNA-binding transcription factor activity
H5029_RS09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_RS09205	COG2031	fatty acid transporter
H5029_RS09210	COG0183	Belongs to the thiolase family
H5029_RS09215	COG0583	DNA-binding transcription factor activity
H5029_RS09220	COG0583	DNA-binding transcription factor activity
H5029_RS09235	COG1027	Aspartate ammonia-lyase
H5029_RS09245	COG0477	Major facilitator Superfamily
H5029_RS09265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_RS09270	COG4521	taurine ABC transporter
H5029_RS09285	COG2188	Transcriptional regulator
H5029_RS09295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H5029_RS09300	COG1733	regulation of RNA biosynthetic process
H5029_RS09305	COG3708	Transcriptional regulator
H5029_RS09305	COG2207	Transcriptional regulator
H5029_RS09320	COG0730	response to heat
H5029_RS09330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_RS09330	COG3453	Protein conserved in bacteria
H5029_RS09340	COG3781	membrane
H5029_RS09345	COG1063	alcohol dehydrogenase
H5029_RS09355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H5029_RS09360	COG0508	dehydrogenase complex catalyzes the overall conversion of
H5029_RS09365	COG0022	dehydrogenase e1 component
H5029_RS09370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H5029_RS09375	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H5029_RS09390	COG3706	GGDEF domain
H5029_RS09405	COG0133	tryptophan synthase activity
H5029_RS09415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5029_RS09450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5029_RS09475	COG2226	methyltransferase
H5029_RS09530	COG0842	Transport permease protein
H5029_RS09535	COG0842	Transport permease protein
H5029_RS09540	COG1131	(ABC) transporter
H5029_RS09555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5029_RS09560	COG4773	Receptor
H5029_RS09580	COG0730	response to heat
H5029_RS09585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H5029_RS09605	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
H5029_RS09620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5029_RS09660	COG4264	IucA IucC family
H5029_RS09665	COG4264	IucA IucC family
H5029_RS09685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H5029_RS09700	COG1960	acyl-CoA dehydrogenase activity
H5029_RS09705	COG1960	acyl-CoA dehydrogenase activity
H5029_RS09710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H5029_RS09715	COG2207	Transcriptional regulator
H5029_RS09720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5029_RS09725	COG0776	regulation of translation
H5029_RS09750	COG0822	iron-sulfur transferase activity
H5029_RS09755	COG0316	Belongs to the HesB IscA family
H5029_RS09785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H5029_RS09805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H5029_RS09810	COG0702	epimerase
H5029_RS09845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5029_RS09855	COG0339	signal peptide processing
H5029_RS09905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H5029_RS09910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H5029_RS09940	COG0776	regulation of translation
H5029_RS10005	COG0084	hydrolase, TatD family'
H5029_RS10025	COG1663	tetraacyldisaccharide 4'-kinase activity
H5029_RS10030	COG1132	(ABC) transporter
H5029_RS10040	COG0811	peptide transport
H5029_RS10045	COG1475	DNA binding
H5029_RS10050	COG1192	Involved in chromosome partitioning
H5029_RS10060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5029_RS10075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5029_RS10080	COG0191	fructose-bisphosphate aldolase activity
H5029_RS10100	COG0424	maF-like protein
H5029_RS10105	COG2850	peptidyl-arginine hydroxylation
H5029_RS10115	COG0640	Transcriptional regulator
H5029_RS10130	COG3619	membrane
H5029_RS10135	COG3122	Protein conserved in bacteria
H5029_RS10140	COG1132	(ABC) transporter
H5029_RS10160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H5029_RS10165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5029_RS10175	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5029_RS10175	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H5029_RS10175	COG0506	proline dehydrogenase activity
H5029_RS10180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H5029_RS10195	COG3698	Phosphodiester glycosidase
H5029_RS10205	COG2353	YceI-like domain
H5029_RS10215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5029_RS10260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5029_RS10260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5029_RS10285	COG3539	Fimbrial protein
H5029_RS10290	COG3121	Chaperone
H5029_RS10315	COG0697	spore germination
H5029_RS10325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5029_RS10335	COG0583	DNA-binding transcription factor activity
H5029_RS10355	COG1309	transcriptional regulator
H5029_RS10370	COG1522	sequence-specific DNA binding
H5029_RS10380	COG1126	abc transporter atp-binding protein
H5029_RS10385	COG0765	amino acid transport
H5029_RS10390	COG0765	amino acid transport
H5029_RS10420	COG1464	Belongs to the NlpA lipoprotein family
H5029_RS10430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5029_RS10435	COG2011	ABC-type metal ion transport system permease component
H5029_RS10440	COG0012	GTP binding
H5029_RS10465	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H5029_RS10505	COG0386	Belongs to the glutathione peroxidase family
H5029_RS10515	COG0436	Aminotransferase
H5029_RS10555	COG3634	alkyl hydroperoxide reductase activity
H5029_RS10570	COG0583	DNA-binding transcription factor activity
H5029_RS10575	COG0798	PFAM Bile acid sodium symporter
H5029_RS10580	COG0640	Transcriptional regulator
H5029_RS10595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H5029_RS10605	COG0583	DNA-binding transcription factor activity
H5029_RS10615	COG1953	Uracil, thiamine, allantoin
H5029_RS10625	COG2175	clavaminate synthase activity
H5029_RS10630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_RS10635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H5029_RS10640	COG4521	taurine ABC transporter
H5029_RS10655	COG0477	Major facilitator Superfamily
H5029_RS10675	COG1271	oxidase subunit
H5029_RS10680	COG1294	oxidase, subunit
H5029_RS10690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_RS10710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5029_RS10730	COG3052	prosthetic group binding
H5029_RS10735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H5029_RS10745	COG2814	Major facilitator Superfamily
H5029_RS10765	COG1346	cytolysis
H5029_RS10775	COG0583	DNA-binding transcription factor activity
H5029_RS10780	COG0625	glutathione transferase activity
H5029_RS10785	COG0625	glutathione transferase activity
H5029_RS10790	COG0583	DNA-binding transcription factor activity
H5029_RS10805	COG1045	serine acetyltransferase
H5029_RS10810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H5029_RS10815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5029_RS10825	COG1280	lysine exporter protein (LysE YggA)
H5029_RS10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_RS10845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_RS10850	COG1126	abc transporter atp-binding protein
H5029_RS10855	COG0765	amino acid transport
H5029_RS10860	COG0765	amino acid transport
H5029_RS10880	COG2205	protein histidine kinase activity
H5029_RS10880	COG0784	Response regulator, receiver
H5029_RS10900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS10970	COG0583	DNA-binding transcription factor activity
H5029_RS10990	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_RS10995	COG1309	transcriptional regulator
H5029_RS11000	COG1960	acyl-CoA dehydrogenase activity
H5029_RS11005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H5029_RS11010	COG1024	Enoyl-CoA hydratase
H5029_RS11015	COG4770	biotin carboxylase activity
H5029_RS11025	COG0583	DNA-binding transcription factor activity
H5029_RS11040	COG1960	acyl-CoA dehydrogenase activity
H5029_RS11050	COG2814	Major facilitator Superfamily
H5029_RS11060	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H5029_RS11065	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H5029_RS11070	COG2814	Major facilitator Superfamily
H5029_RS11075	COG1960	acyl-CoA dehydrogenase activity
H5029_RS11080	COG1024	Enoyl-CoA hydratase
H5029_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS11090	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_RS11095	COG0183	Belongs to the thiolase family
H5029_RS11105	COG2814	Major facilitator Superfamily
H5029_RS11115	COG1024	Enoyl-CoA hydratase
H5029_RS11130	COG1960	acyl-CoA dehydrogenase activity
H5029_RS11135	COG2814	Major facilitator Superfamily
H5029_RS11140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5029_RS11145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H5029_RS11160	COG3842	ATPase activity
H5029_RS11165	COG1840	ABC-type Fe3 transport system, periplasmic component
H5029_RS11175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_RS11180	COG1414	Transcriptional regulator
H5029_RS11190	COG0583	DNA-binding transcription factor activity
H5029_RS11195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H5029_RS11200	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS11210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
H5029_RS11220	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS11225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_RS11230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_RS11235	COG2267	carboxylic ester hydrolase activity
H5029_RS11255	COG3038	cytochrome b561
H5029_RS11260	COG0753	catalase activity
H5029_RS11295	COG2050	protein possibly involved in aromatic compounds catabolism
H5029_RS11305	COG3327	negative regulation of DNA-templated transcription, initiation
H5029_RS11310	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
H5029_RS11315	COG0183	Belongs to the thiolase family
H5029_RS11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_RS11325	COG1024	Enoyl-CoA hydratase
H5029_RS11330	COG1024	Enoyl-CoA hydratase
H5029_RS11335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H5029_RS11340	COG2151	metal-sulfur cluster biosynthetic enzyme
H5029_RS11345	COG3396	Phenylacetate-CoA oxygenase
H5029_RS11350	COG3460	Phenylacetate-CoA oxygenase
H5029_RS11355	COG3396	Phenylacetate-CoA oxygenase
H5029_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS11360	COG2030	dehydratase
H5029_RS11365	COG1760	l-serine dehydratase
H5029_RS11370	COG0531	amino acid
H5029_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS11390	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_RS11400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5029_RS11420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_RS11430	COG0789	Transcriptional regulator
H5029_RS11445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5029_RS11460	COG2807	transmembrane transport
H5029_RS11465	COG0590	tRNA wobble adenosine to inosine editing
H5029_RS11580	COG1116	anion transmembrane transporter activity
H5029_RS11585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5029_RS11595	COG0864	Transcriptional regulator
H5029_RS11615	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5029_RS11620	COG0439	Biotin carboxylase
H5029_RS11635	COG1063	alcohol dehydrogenase
H5029_RS11645	COG1309	transcriptional regulator
H5029_RS11690	COG1914	H( )-stimulated, divalent metal cation uptake system
H5029_RS11695	COG0583	DNA-binding transcription factor activity
H5029_RS11745	COG1250	3-hydroxyacyl-CoA dehydrogenase
H5029_RS11775	COG1560	Kdo2-lipid A biosynthetic process
H5029_RS11790	COG5006	permease, DMT superfamily
H5029_RS11795	COG1522	sequence-specific DNA binding
H5029_RS11810	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H5029_RS11820	COG4122	O-methyltransferase activity
H5029_RS11850	COG1538	Outer membrane efflux protein
H5029_RS11855	COG1137	ATPase activity
H5029_RS11860	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
H5029_RS11870	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H5029_RS11875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5029_RS11875	COG0517	IMP dehydrogenase activity
H5029_RS11910	COG2814	Major facilitator Superfamily
H5029_RS11945	COG1278	Cold shock
H5029_RS11950	COG1280	lysine exporter protein (LysE YggA)
H5029_RS11980	COG1570	exodeoxyribonuclease VII activity
H5029_RS12030	COG0583	DNA-binding transcription factor activity
H5029_RS12035	COG4638	Rieske (2fe-2S)
H5029_RS12040	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
H5029_RS12045	COG0633	Ferredoxin
H5029_RS12045	COG0543	2 iron, 2 sulfur cluster binding
H5029_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS12055	COG3135	benzoate transporter
H5029_RS12060	COG2814	Major facilitator Superfamily
H5029_RS12075	COG1643	Atp-dependent helicase
H5029_RS12080	COG0450	alkyl hydroperoxide reductase
H5029_RS12090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5029_RS12100	COG3634	alkyl hydroperoxide reductase activity
H5029_RS12120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5029_RS12125	COG0625	glutathione transferase activity
H5029_RS12135	COG2885	chlorophyll binding
H5029_RS12170	COG0542	response to heat
H5029_RS12185	COG1765	OsmC-like protein
H5029_RS12205	COG0667	Aldo Keto reductase
H5029_RS12220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H5029_RS12230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H5029_RS12240	COG0527	aspartate kinase activity
H5029_RS12250	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5029_RS12260	COG3038	cytochrome b561
H5029_RS12265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H5029_RS12270	COG2252	PERMEase
H5029_RS12280	COG2072	flavoprotein involved in K transport
H5029_RS12295	COG1741	Belongs to the pirin family
H5029_RS12300	COG1309	transcriptional regulator
H5029_RS12325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H5029_RS12365	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_RS12365	COG1902	pentaerythritol trinitrate reductase activity
H5029_RS12375	COG2203	Gaf domain
H5029_RS12375	COG3706	GGDEF domain
H5029_RS12375	COG5001	Diguanylate cyclase
H5029_RS12375	COG4251	negative regulation of phosphorylation
H5029_RS12385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5029_RS12405	COG4172	Belongs to the ABC transporter superfamily
H5029_RS12410	COG4239	(ABC) transporter, permease
H5029_RS12415	COG4174	ABC transporter (Permease)
H5029_RS12425	COG1388	LysM domain
H5029_RS12425	COG0741	lytic transglycosylase activity
H5029_RS12425	COG1388	LysM domain
H5029_RS12425	COG0741	lytic transglycosylase activity
H5029_RS12430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H5029_RS12470	COG0583	DNA-binding transcription factor activity
H5029_RS12475	COG1279	arginine transmembrane transporter activity
H5029_RS12495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_RS12500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H5029_RS12505	COG0006	proline dipeptidase activity
H5029_RS12545	COG2194	sulfuric ester hydrolase activity
H5029_RS12590	COG0739	heme binding
H5029_RS12915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H5029_RS12940	COG3384	dioxygenase
H5029_RS12950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H5029_RS12955	COG2878	Part of a membrane complex involved in electron transport
H5029_RS12960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5029_RS12985	COG0768	penicillin binding
H5029_RS12990	COG0742	ribosomal rna small subunit methyltransferase
H5029_RS13005	COG0830	nickel cation binding
H5029_RS13050	COG1253	flavin adenine dinucleotide binding
H5029_RS13055	COG2851	Citrate transporter
H5029_RS13110	COG1773	rubredoxin
H5029_RS13115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H5029_RS13125	COG0583	DNA-binding transcription factor activity
H5029_RS13150	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H5029_RS13155	COG4181	ATPase activity
H5029_RS13200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H5029_RS13220	COG0306	phosphate transporter
H5029_RS13230	COG3958	Transketolase
H5029_RS13235	COG3959	Transketolase, thiamine diphosphate binding domain
H5029_RS13240	COG2271	Major facilitator Superfamily
H5029_RS13245	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS13250	COG0583	DNA-binding transcription factor activity
H5029_RS13265	COG2223	nitrite transmembrane transporter activity
H5029_RS13270	COG2207	Transcriptional regulator
H5029_RS13275	COG2066	Belongs to the glutaminase family
H5029_RS13280	COG0242	peptide deformylase activity
H5029_RS13285	COG0477	Major facilitator Superfamily
H5029_RS13295	COG0028	Belongs to the TPP enzyme family
H5029_RS13310	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS13315	COG2267	carboxylic ester hydrolase activity
H5029_RS13325	COG2271	Major facilitator Superfamily
H5029_RS13330	COG0446	pyridine nucleotide-disulphide oxidoreductase
H5029_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS13360	COG1414	Transcriptional regulator
H5029_RS13375	COG1024	Enoyl-CoA hydratase
H5029_RS13385	COG1215	transferase activity, transferring glycosyl groups
H5029_RS13390	COG1649	PFAM Uncharacterised BCR, COG1649
H5029_RS13390	COG0726	polysaccharide deacetylase
H5029_RS13400	COG4681	YaeQ
H5029_RS13410	COG0523	cobalamin synthesis protein
H5029_RS13420	COG1607	acyl-coa hydrolase
H5029_RS13430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_RS13435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H5029_RS13440	COG1309	transcriptional regulator
H5029_RS13465	COG2040	homocysteine
H5029_RS13470	COG0531	amino acid
H5029_RS13525	COG1595	DNA-templated transcription, initiation
H5029_RS13535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_RS13540	COG0477	Major facilitator Superfamily
H5029_RS13560	COG0084	hydrolase, TatD family'
H5029_RS13595	COG0629	single-stranded DNA binding
H5029_RS13650	COG0582	viral genome integration into host DNA
H5029_RS13665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_RS13790	COG3566	protein conserved in bacteria
H5029_RS13805	COG3567	Phage-associated protein, HI1409 family
H5029_RS13810	COG5410	chromosome segregation
H5029_RS13895	COG4197	protein conserved in bacteria, prophage-related
H5029_RS13900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H5029_RS13965	COG0405	Gamma-glutamyltransferase
H5029_RS13970	COG2814	Major facilitator Superfamily
H5029_RS13980	COG2050	protein possibly involved in aromatic compounds catabolism
H5029_RS13995	COG1090	epimerase
H5029_RS14015	COG0420	3'-5' exonuclease activity
H5029_RS14040	COG0735	belongs to the Fur family
H5029_RS14045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5029_RS14065	COG0121	glutamine amidotransferase
H5029_RS14080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5029_RS14090	COG0210	DNA helicase
H5029_RS14095	COG2885	chlorophyll binding
H5029_RS14100	COG0204	Acyl-transferase
H5029_RS14115	COG2894	cell division
H5029_RS14135	COG1280	lysine exporter protein (LysE YggA)
H5029_RS14140	COG1674	ftsk spoiiie
H5029_RS14140	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5029_RS14145	COG0492	ferredoxin-NADP+ reductase activity
H5029_RS14150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5029_RS14160	COG0456	acetyltransferase
H5029_RS14205	COG1981	membrane
H5029_RS14220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5029_RS14220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5029_RS14240	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS14250	COG0657	acetylesterase activity
H5029_RS14260	COG0473	3-isopropylmalate dehydrogenase activity
H5029_RS14265	COG0583	DNA-binding transcription factor activity
H5029_RS14285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_RS14310	COG0564	pseudouridine synthase activity
H5029_RS14320	COG0358	DNA primase activity
H5029_RS14335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
H5029_RS14365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5029_RS14395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5029_RS14405	COG0351	phosphomethylpyrimidine kinase
H5029_RS14405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5029_RS14405	COG0352	thiamine-phosphate diphosphorylase activity
H5029_RS14410	COG1652	LysM domain
H5029_RS14435	COG1399	metal-binding, possibly nucleic acid-binding protein
H5029_RS14440	COG3101	peptidyl-lysine hydroxylation
H5029_RS14445	COG0009	L-threonylcarbamoyladenylate synthase
H5029_RS14450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H5029_RS14455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H5029_RS14470	COG4106	trans-aconitate 2-methyltransferase activity
H5029_RS14485	COG0596	Alpha beta hydrolase
H5029_RS14485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_RS14485	COG2226	methyltransferase
H5029_RS14490	COG1877	trehalose-phosphatase activity
H5029_RS14495	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H5029_RS14500	COG2223	nitrite transmembrane transporter activity
H5029_RS14520	COG1196	nuclear chromosome segregation
H5029_RS14530	COG0730	response to heat
H5029_RS14545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5029_RS14555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5029_RS14605	COG0489	protein tyrosine kinase activity
H5029_RS14615	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_RS14615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_RS14645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
H5029_RS14650	COG2081	HI0933 family
H5029_RS14660	COG0668	transmembrane transport
H5029_RS14680	COG0583	DNA-binding transcription factor activity
H5029_RS14700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5029_RS14705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5029_RS14735	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H5029_RS14775	COG0745	RESPONSE REGULATOR receiver
H5029_RS14795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5029_RS14805	COG2205	protein histidine kinase activity
H5029_RS14875	COG4993	Dehydrogenase
H5029_RS14900	COG0384	phenazine biosynthesis protein PhzF
H5029_RS14920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H5029_RS14935	COG0583	DNA-binding transcription factor activity
H5029_RS14965	COG0583	DNA-binding transcription factor activity
H5029_RS14980	COG0583	DNA-binding transcription factor activity
H5029_RS14985	COG1053	succinate dehydrogenase
H5029_RS14995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H5029_RS15000	COG2814	Major facilitator Superfamily
H5029_RS15005	COG1960	acyl-CoA dehydrogenase activity
H5029_RS15010	COG0583	DNA-binding transcription factor activity
H5029_RS15015	COG1063	alcohol dehydrogenase
H5029_RS15045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H5029_RS15050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H5029_RS15055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5029_RS15070	COG3667	copper resistance
H5029_RS15075	COG2132	Multicopper oxidase
H5029_RS15085	COG0561	phosphatase activity
H5029_RS15090	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5029_RS15115	COG1214	PFAM Peptidase M22, glycoprotease
H5029_RS15170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5029_RS15180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H5029_RS15185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H5029_RS15190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H5029_RS15250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H5029_RS15260	COG1846	Transcriptional regulator
H5029_RS15265	COG1764	response to oxidative stress
H5029_RS15315	COG0037	tRNA processing
H5029_RS15325	COG0248	Ppx GppA phosphatase
H5029_RS15355	COG0072	phenylalanine-tRNA ligase activity
H5029_RS15395	COG1238	metal cluster binding
H5029_RS15400	COG0625	glutathione transferase activity
H5029_RS15415	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_RS15420	COG3028	Belongs to the UPF0307 family
H5029_RS15425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H5029_RS15445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H5029_RS15450	COG0617	tRNA 3'-terminal CCA addition
H5029_RS15455	COG1555	photosystem II stabilization
H5029_RS15460	COG3956	TIGRFAM MazG family protein
H5029_RS15470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5029_RS15490	COG0784	Response regulator, receiver
H5029_RS15490	COG2205	protein histidine kinase activity
H5029_RS15490	COG5002	protein histidine kinase activity
H5029_RS15495	COG1024	Enoyl-CoA hydratase
H5029_RS15500	COG2084	Dehydrogenase
H5029_RS15505	COG3622	Belongs to the hyi family
H5029_RS15535	COG0697	spore germination
H5029_RS15545	COG2814	Major facilitator Superfamily
H5029_RS15550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5029_RS15560	COG0583	DNA-binding transcription factor activity
H5029_RS15570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H5029_RS15580	COG0084	hydrolase, TatD family'
H5029_RS15595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H5029_RS15625	COG0440	acetolactate synthase activity
H5029_RS15630	COG0028	Belongs to the TPP enzyme family
H5029_RS15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5029_RS15665	COG0577	efflux transmembrane transporter activity
H5029_RS15665	COG1136	(ABC) transporter
H5029_RS15670	COG1538	Outer membrane efflux protein
H5029_RS15685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H5029_RS15690	COG1162	GTPase activity
H5029_RS15700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H5029_RS15740	COG1426	Protein conserved in bacteria
H5029_RS15775	COG0793	Belongs to the peptidase S41A family
H5029_RS15800	COG1012	belongs to the aldehyde dehydrogenase family
H5029_RS15805	COG3265	gluconokinase activity
H5029_RS15815	COG0800	Aldolase
H5029_RS15825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H5029_RS15830	COG0280	phosphate acetyltransferase
H5029_RS15830	COG0857	belongs to the CobB CobQ family
H5029_RS15835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
H5029_RS15835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
H5029_RS15855	COG0740	serine-type endopeptidase activity
H5029_RS15865	COG4774	siderophore transport
H5029_RS15875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5029_RS15885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H5029_RS15885	COG2813	Specifically methylates the guanine in position
H5029_RS15985	COG0788	formyltetrahydrofolate deformylase activity
H5029_RS16010	COG4651	solute:proton antiporter activity
H5029_RS16010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_RS16030	COG0724	RNA recognition motif
H5029_RS16035	COG0210	DNA helicase
H5029_RS16060	COG1733	regulation of RNA biosynthetic process
H5029_RS16070	COG2900	Belongs to the SlyX family
H5029_RS16075	COG0488	(ABC) transporter
H5029_RS16080	COG1280	lysine exporter protein (LysE YggA)
H5029_RS16085	COG1560	Kdo2-lipid A biosynthetic process
H5029_RS16095	COG1301	dicarboxylic acid transport
H5029_RS16120	COG0252	asparaginase activity
H5029_RS16150	COG0473	3-isopropylmalate dehydrogenase activity
H5029_RS16205	COG0583	DNA-binding transcription factor activity
H5029_RS16215	COG0625	glutathione transferase activity
H5029_RS16220	COG2378	regulation of single-species biofilm formation
H5029_RS16225	COG0546	phosphoglycolate phosphatase activity
H5029_RS16235	COG1530	ribonuclease E activity
H5029_RS16240	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_RS16255	COG0583	DNA-binding transcription factor activity
H5029_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS16265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5029_RS16275	COG0534	Mate efflux family protein
H5029_RS16290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5029_RS16320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5029_RS16320	COG0493	'glutamate synthase
H5029_RS16330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
H5029_RS16335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H5029_RS16350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5029_RS16360	COG0644	oxidoreductase
H5029_RS16360	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
H5029_RS16370	COG0425	Belongs to the sulfur carrier protein TusA family
H5029_RS16375	COG4535	Mg2 and Co2 transporter CorC
H5029_RS16385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5029_RS16405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5029_RS16410	COG0475	glutathione-regulated potassium exporter activity
H5029_RS16410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5029_RS16425	COG0484	heat shock protein binding
H5029_RS16430	COG0789	Transcriptional regulator
H5029_RS16435	COG0598	Magnesium transport protein CorA
H5029_RS16450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H5029_RS16455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5029_RS16460	COG1074	ATP-dependent DNA helicase activity
H5029_RS16465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H5029_RS16485	COG2226	methyltransferase
H5029_RS16495	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H5029_RS16510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5029_RS16525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5029_RS16525	COG2111	Na H antiporter
H5029_RS16530	COG1006	Multisubunit Na H antiporter MnhC subunit
H5029_RS16535	COG0651	ATP synthesis coupled electron transport
H5029_RS16540	COG1863	multisubunit Na H antiporter MnhE subunit
H5029_RS16545	COG2212	antiporter activity
H5029_RS16550	COG1320	monovalent cation:proton antiporter activity
H5029_RS16565	COG0195	Participates in both transcription termination and antitermination
H5029_RS16615	COG0237	dephospho-CoA kinase activity
H5029_RS16625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5029_RS16640	COG0497	DNA recombination
H5029_RS16650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H5029_RS16680	COG2169	Transcriptional regulator
H5029_RS16680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5029_RS16685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H5029_RS16740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H5029_RS16755	COG0326	Molecular chaperone. Has ATPase activity
H5029_RS16770	COG2056	Na+-H+ antiporter family
H5029_RS16870	COG0546	phosphoglycolate phosphatase activity
H5029_RS16875	COG1716	ATPase activity
H5029_RS16920	COG0181	hydroxymethylbilane synthase activity
H5029_RS16930	COG3275	phosphorelay sensor kinase activity
H5029_RS16955	COG0697	spore germination
H5029_RS16980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H5029_RS16985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5029_RS16990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5029_RS16995	COG0772	Belongs to the SEDS family
H5029_RS17020	COG4974	Belongs to the 'phage' integrase family
H5029_RS17025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_RS17035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5029_RS17045	COG2197	response regulator
H5029_RS17060	COG0793	Belongs to the peptidase S41A family
H5029_RS17065	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H5029_RS17070	COG0795	lipopolysaccharide-transporting ATPase activity
H5029_RS17110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5029_RS17110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5029_RS17120	COG0004	ammonium transporteR
H5029_RS17125	COG0347	Belongs to the P(II) protein family
H5029_RS17135	COG0606	chelatase, subunit chli
H5029_RS17145	COG0659	secondary active sulfate transmembrane transporter activity
H5029_RS17150	COG0589	response to stress
H5029_RS17190	COG0606	chelatase, subunit chli
H5029_RS17195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H5029_RS17205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H5029_RS17220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5029_RS17235	COG0318	PFAM AMP-dependent synthetase and ligase
H5029_RS17245	COG0477	Major facilitator Superfamily
H5029_RS17250	COG2860	membrane
H5029_RS17260	COG1253	flavin adenine dinucleotide binding
H5029_RS17270	COG0477	Major facilitator Superfamily
H5029_RS17280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H5029_RS17315	COG0655	NAD(P)H dehydrogenase (quinone) activity
H5029_RS17325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5029_RS17360	COG1309	transcriptional regulator
H5029_RS17395	COG0758	DNA mediated transformation
H5029_RS17405	COG0697	spore germination
H5029_RS17410	COG1309	transcriptional regulator
H5029_RS17425	COG0386	Belongs to the glutathione peroxidase family
H5029_RS17490	COG1121	(ABC) transporter
H5029_RS17495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5029_RS17500	COG1280	lysine exporter protein (LysE YggA)
H5029_RS17505	COG2837	iron assimilation
H5029_RS17510	COG0281	malic enzyme
H5029_RS17555	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5029_RS17555	COG0519	Catalyzes the synthesis of GMP from XMP
H5029_RS17560	COG4399	Belongs to the UPF0754 family
H5029_RS17565	COG2259	Doxx family
H5029_RS17570	COG0586	Pfam SNARE associated Golgi protein
H5029_RS17585	COG1192	Involved in chromosome partitioning
H5029_RS17595	COG0271	Belongs to the BolA IbaG family
H5029_RS17635	COG3321	synthase
H5029_RS17635	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
H5029_RS17635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5029_RS17635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H5029_RS17640	COG1960	acyl-CoA dehydrogenase activity
H5029_RS17650	COG2197	response regulator
H5029_RS17660	COG3916	Acyl-homoserine-lactone synthase
H5029_RS17665	COG0477	Major facilitator Superfamily
H5029_RS17670	COG1024	Enoyl-CoA hydratase
H5029_RS17675	COG1024	Enoyl-CoA hydratase
H5029_RS17680	COG1960	acyl-CoA dehydrogenase activity
H5029_RS17685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5029_RS17705	COG1113	amino acid transport
H5029_RS17710	COG1113	amino acid transport
H5029_RS17715	COG0251	oxidation-reduction process
H5029_RS17755	COG0564	pseudouridine synthase activity
H5029_RS17800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H5029_RS17815	COG1802	Transcriptional regulator
H5029_RS17825	COG1448	Aminotransferase
H5029_RS17830	COG0277	FAD linked oxidase domain protein
H5029_RS17840	COG2186	Transcriptional regulator
H5029_RS17850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5029_RS17860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5029_RS17875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H5029_RS17880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5029_RS17885	COG1216	Glycosyl transferase, family 2
H5029_RS17900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H5029_RS17900	COG1215	transferase activity, transferring glycosyl groups
H5029_RS17905	COG1442	glycosyl transferase family 8
H5029_RS17905	COG1216	Glycosyl transferase, family 2
H5029_RS17915	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H5029_RS17920	COG1596	polysaccharide export
H5029_RS17945	COG0728	peptidoglycan biosynthetic process
H5029_RS17950	COG3023	N-Acetylmuramoyl-L-alanine amidase
H5029_RS18005	COG0546	phosphoglycolate phosphatase activity
H5029_RS18010	COG1028	Short-chain dehydrogenase reductase Sdr
H5029_RS18030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_RS18035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H5029_RS18040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H5029_RS18045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H5029_RS18050	COG1116	anion transmembrane transporter activity
H5029_RS18055	COG1309	transcriptional regulator
H5029_RS18060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5029_RS18070	COG0196	riboflavin kinase activity
H5029_RS18075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H5029_RS18085	COG1047	Peptidyl-prolyl cis-trans
H5029_RS18125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5029_RS18130	COG0657	acetylesterase activity
H5029_RS18180	COG2951	lytic endotransglycosylase activity
H5029_RS18185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H5029_RS18200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H5029_RS18210	COG0671	phosphoesterase, PA-phosphatase related
H5029_RS18215	COG0861	Integral membrane protein TerC family
H5029_RS18225	COG0754	glutathionylspermidine amidase activity
H5029_RS18235	COG0402	S-adenosylhomocysteine deaminase activity
H5029_RS18250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H5029_RS18255	COG1230	cation diffusion facilitator family transporter
H5029_RS18270	COG0706	membrane insertase activity