locus-tag class description HBN41_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBN41_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBN41_RS00030 ENOG4105DQR SNARE associated Golgi HBN41_RS00035 ENOG4105C5H ABC transporter HBN41_RS00040 ENOG4108821 RND type efflux pump HBN41_RS00045 ENOG4108821 RND type efflux pump HBN41_RS00050 ENOG4108821 RND type efflux pump HBN41_RS00060 ENOG4105D74 hydrolase HBN41_RS00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HBN41_RS00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HBN41_RS00110 ENOG4105C8J )-transporter HBN41_RS00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HBN41_RS00150 ENOG4105C2W permease HBN41_RS00160 ENOG4108IG5 Transcriptional regulator HBN41_RS00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HBN41_RS00200 ENOG4105F27 Major Facilitator HBN41_RS00205 ENOG4105CV8 reductase HBN41_RS00210 ENOG4105HEI LysR family (Transcriptional regulator HBN41_RS00230 ENOG4105DQ4 alcohol dehydrogenase HBN41_RS00235 ENOG4108R3E Dna-3-methyladenine glycosylase i HBN41_RS00250 ENOG4105CEN a g-specific adenine glycosylase HBN41_RS00270 ENOG4108ZZ3 UPF0260 protein HBN41_RS00280 ENOG4105D1H recombination factor protein RarA HBN41_RS00285 ENOG4105S64 Formate nitrite transporter HBN41_RS00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBN41_RS00310 ENOG4108RWI nicotinamidase HBN41_RS00315 ENOG4105C09 Bile acid HBN41_RS00320 ENOG4107QI1 Mate efflux family protein HBN41_RS00325 ENOG4105EWC Purine nucleoside phosphorylase HBN41_RS00345 ENOG4108RXX maleylacetoacetate isomerase HBN41_RS00355 ENOG4105C85 amino acid HBN41_RS00365 ENOG4105CKI cobalamin synthesis protein HBN41_RS00375 ENOG4105CZE histidine utilization repressor HBN41_RS00380 ENOG41090B9 response to stress HBN41_RS00395 ENOG4105C85 amino acid HBN41_RS00405 ENOG41088SP formiminoglutamate hydrolase HBN41_RS00420 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HBN41_RS00425 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HBN41_RS00435 ENOG4108ZAI phosphatidylglycerophosphatase a HBN41_RS00440 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HBN41_RS00455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HBN41_RS00490 ENOG4105KHC sulfurtransferase HBN41_RS00525 ENOG4105BZU Histidine kinase HBN41_RS00530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBN41_RS00545 ENOG4107QJQ Mate efflux family protein HBN41_RS00550 ENOG4105CHM Aminotransferase HBN41_RS00555 ENOG4106BRA Membrane HBN41_RS00570 ENOG4105D9M gamma-glutamylcysteine synthetase HBN41_RS00580 ENOG4105CS6 Rhs element vgr protein HBN41_RS00585 ENOG4105K4H Nlp p60 protein HBN41_RS00600 ENOG4105IPS esterase HBN41_RS00605 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBN41_RS00610 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HBN41_RS00615 ENOG4108Z2U ureidoglycolate hydrolase HBN41_RS00625 ENOG41061H0 Monooxygenase HBN41_RS00640 ENOG41084YZ Hydrolase HBN41_RS00670 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HBN41_RS00675 ENOG4105BZU Histidine kinase HBN41_RS00690 ENOG4105KUZ arsenate reductase HBN41_RS00695 ENOG4105CGK Exodeoxyribonuclease III HBN41_RS00715 ENOG4105D7Z glutathione synthase HBN41_RS00735 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HBN41_RS00740 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HBN41_RS00745 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HBN41_RS00760 ENOG41063SB peptidase HBN41_RS00765 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HBN41_RS00770 ENOG4107QSN dihydrolipoamide acetyltransferase HBN41_RS00785 ENOG4105E0K tonB-dependent siderophore receptor HBN41_RS00800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HBN41_RS00815 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HBN41_RS00835 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HBN41_RS00840 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HBN41_RS00850 ENOG4105D64 Mechanosensitive ion channel HBN41_RS00860 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HBN41_RS00865 ENOG4108W2Y isochorismatase HBN41_RS00875 ENOG4105D5G Transposase HBN41_RS00880 ENOG4105FBW Monooxygenase HBN41_RS00885 ENOG4108UZX fmn reductase HBN41_RS00900 ENOG4105BZU Histidine kinase HBN41_RS00905 ENOG41062QD Membrane HBN41_RS00910 ENOG4107QN1 sodium solute HBN41_RS00920 ENOG4105C94 Transporter HBN41_RS00930 ENOG4105BZU Histidine kinase HBN41_RS00940 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HBN41_RS00945 ENOG4108WUH Transcriptional regulator, TetR family HBN41_RS00950 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HBN41_RS00960 ENOG4105RA2 Membrane HBN41_RS00965 ENOG4105DWF phosphomethylpyrimidine kinase HBN41_RS00975 ENOG4107RDB Major Facilitator HBN41_RS00980 ENOG4108UUM single-stranded DNA-binding protein HBN41_RS00990 ENOG4108UMN azlc family HBN41_RS01000 ENOG4105C85 amino acid HBN41_RS01010 ENOG4108JPW Aminotransferase HBN41_RS01015 ENOG4105C26 Dehydrogenase HBN41_RS01025 ENOG4105CHJ isochorismatase hydrolase HBN41_RS01030 ENOG4105EUB pirin domain protein HBN41_RS01040 ENOG4105CVN desaturase HBN41_RS01060 ENOG4105D94 Major Facilitator Superfamily HBN41_RS01065 ENOG4106NZI LysR family Transcriptional regulator HBN41_RS01085 ENOG4105CPC Aldo Keto reductase HBN41_RS01090 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HBN41_RS01115 ENOG4105KVH Transcriptional regulator HBN41_RS01120 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HBN41_RS01185 ENOG4105CUV Homoserine Kinase HBN41_RS01200 ENOG41061CK Antibiotic biosynthesis monooxygenase HBN41_RS01230 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HBN41_RS01255 ENOG4108R6G acetyltransferase HBN41_RS01260 ENOG4105CYC Transferase HBN41_RS01270 ENOG4105E0F Histidine kinase HBN41_RS01285 ENOG4105CHH sulfate transporter HBN41_RS01290 ENOG4105PDP Short chain dehydrogenase HBN41_RS01300 ENOG4105C5H ABC transporter HBN41_RS01385 ENOG4108IQI permease HBN41_RS01410 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HBN41_RS01425 ENOG4105CJN penicillin-binding protein HBN41_RS01430 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HBN41_RS01435 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HBN41_RS01450 ENOG4105DHI Methyltransferase HBN41_RS01455 ENOG4108JQC penicillin-binding protein 1A HBN41_RS01480 ENOG4105E4G Type IV pilus HBN41_RS01500 ENOG4105CBC glutamate synthase HBN41_RS01505 ENOG4105BZ8 glutamate synthase HBN41_RS01515 ENOG4108V0P LemA family HBN41_RS01520 ENOG4105HA9 of methanol dehydrogenase type HBN41_RS01540 ENOG4108YSG O-Antigen polymerase HBN41_RS01545 ENOG4108UQY Iron-storage protein HBN41_RS01555 ENOG4105KME endoribonuclease L-psp HBN41_RS01560 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HBN41_RS01575 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HBN41_RS01625 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HBN41_RS01640 ENOG4107IFA Lipase (EC 3.1.1.3) HBN41_RS01645 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HBN41_RS01650 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HBN41_RS01675 ENOG4108JQ1 Dehydrogenase HBN41_RS01680 ENOG4105CQB FAD linked oxidase domain protein HBN41_RS01690 ENOG4105VRH Antibiotic biosynthesis monooxygenase HBN41_RS01695 ENOG4105NF4 modulator of drug activity HBN41_RS01705 ENOG4107QF7 multi-drug HBN41_RS01710 ENOG4105EM2 membrane HBN41_RS01715 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBN41_RS01720 ENOG4105IPI Membrane HBN41_RS01725 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HBN41_RS01755 ENOG4108IQI permease HBN41_RS01760 ENOG4105D82 Glutamate dehydrogenase HBN41_RS01765 ENOG4105C8Y Acetylornithine aminotransferase HBN41_RS01775 ENOG4105C26 Dehydrogenase HBN41_RS01860 ENOG4105W87 Cbs domain HBN41_RS01865 ENOG41067S9 phage shock protein C, PspC HBN41_RS01875 ENOG4105CSU acyl-Coa dehydrogenase HBN41_RS01890 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HBN41_RS01905 ENOG4105ECY inositol monophosphatase HBN41_RS01910 ENOG4105C1J atp-dependent rna helicase HBN41_RS01920 ENOG4105DHJ ABC, transporter HBN41_RS01925 ENOG4105CY3 ABC transporter, permease HBN41_RS01935 ENOG4105E3I toluene tolerance HBN41_RS01945 ENOG4105D7N magnesium and cobalt transport protein CorA HBN41_RS01950 ENOG4108URH decarboxylase HBN41_RS01960 ENOG4105MJ2 Competence protein HBN41_RS01965 ENOG4105CB5 ATP-dependent DNA helicase recG HBN41_RS01985 ENOG4105C29 acyl-CoA thioesterase HBN41_RS01990 ENOG4105CK2 sodium dicarboxylate symporter HBN41_RS02005 ENOG4105KPV Transcriptional regulator HBN41_RS02015 ENOG4105D7A ATP-binding protein HBN41_RS02025 ENOG41089BK Glutamine amido-transferase HBN41_RS02135 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HBN41_RS02175 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS02210 ENOG4105VKU nucleicacid-binding protein HBN41_RS02215 ENOG4105DGW oligopeptidase A HBN41_RS02220 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HBN41_RS02265 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HBN41_RS02270 ENOG4108K2B transcriptional regulator HBN41_RS02280 ENOG4107S2Z UPF0761 membrane protein HBN41_RS02285 ENOG4105CS1 NAD(P)H quinone oxidoreductase HBN41_RS02320 ENOG4105C9A Phoh family HBN41_RS02330 ENOG4105E4C Lytic transglycosylase catalytic HBN41_RS02360 ENOG4105D6S protein involved in catabolism of external DNA HBN41_RS02365 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBN41_RS02410 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS02415 ENOG4108RZE Tetr family transcriptional regulator HBN41_RS02430 ENOG4107QX3 carboxylase HBN41_RS02435 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS02455 ENOG4105KB2 stringent starvation protein b HBN41_RS02460 ENOG4107MKT Stringent starvation protein a HBN41_RS02465 ENOG4108UJD 30S ribosomal protein S9 HBN41_RS02475 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HBN41_RS02480 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HBN41_RS02485 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HBN41_RS02505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HBN41_RS02515 ENOG4107RZC phospholipase d HBN41_RS02525 ENOG4105UYK outer membrane protein a HBN41_RS02530 ENOG4108KHX Diguanylate cyclase HBN41_RS02565 ENOG4107QN2 dihydrolipoyl dehydrogenase HBN41_RS02580 ENOG4107U2T alpha beta HBN41_RS02590 ENOG4105NAU thioesterase Superfamily protein HBN41_RS02620 ENOG4105K9H YciI-like protein HBN41_RS02630 ENOG4105DB7 PHP domain protein HBN41_RS02635 ENOG4105FFC UPF0187 protein HBN41_RS02645 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HBN41_RS02650 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HBN41_RS02655 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HBN41_RS02660 ENOG4105VIE preprotein translocase, subunit YajC HBN41_RS02690 ENOG4105BZU Histidine kinase HBN41_RS02695 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HBN41_RS02700 ENOG4105CM2 brancheD-chain amino acid aminotransferase HBN41_RS02715 ENOG4107BJW polysaccharide deacetylase HBN41_RS02725 ENOG4108PQP glycosyl transferase group 1 HBN41_RS02765 ENOG4105UGU tonB-dependent Receptor HBN41_RS02785 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HBN41_RS02790 ENOG4108K3A Glutathione S-transferase HBN41_RS02795 ENOG4108R4R Iron-regulated virulence regulatory protein HBN41_RS02800 ENOG4105CSU acyl-Coa dehydrogenase HBN41_RS02805 ENOG4105CSU acyl-Coa dehydrogenase HBN41_RS02815 ENOG4105EB3 Histidine kinase HBN41_RS02820 ENOG4105E3W Two component transcriptional regulator (Winged helix family HBN41_RS02825 ENOG4105CNG UPF0061 protein HBN41_RS02845 ENOG4108WBT adenosyltransferase HBN41_RS02895 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HBN41_RS02915 ENOG4105D3R alkyl hydroperoxide reductase HBN41_RS02930 ENOG4105CSH Transporter HBN41_RS02935 ENOG4108UT2 hemolysin iii HBN41_RS02970 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS02975 ENOG4108R6W Transcriptional regulator, ARAC family HBN41_RS02985 ENOG4105TW1 Carbohydrate-selective porin OprB HBN41_RS02990 ENOG4105DZG Dehydrogenase HBN41_RS02995 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HBN41_RS03005 ENOG410814C multidrug resistance protein HBN41_RS03015 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS03025 ENOG4108WHA ompa motb domain protein HBN41_RS03035 ENOG4105E0Y RtcB Protein HBN41_RS03040 ENOG4108IQI permease HBN41_RS03050 ENOG4105C2W permease HBN41_RS03055 ENOG4105CI3 gtp-binding protein typa HBN41_RS03070 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBN41_RS03080 ENOG4108VX5 3-methyladenine DNA glycosylase HBN41_RS03085 ENOG4105CHB tonB-dependent Receptor HBN41_RS03100 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HBN41_RS03105 ENOG4108N2Y auxin Efflux HBN41_RS03115 ENOG4105T95 Thiol disulfide interChange protein HBN41_RS03120 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HBN41_RS03130 ENOG4105K78 MarR family Transcriptional regulator HBN41_RS03135 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HBN41_RS03140 ENOG4105KWI UPF0339 protein HBN41_RS03165 ENOG4108UNF response regulator HBN41_RS03170 ENOG4105M3Z response regulator HBN41_RS03175 ENOG4108ZGA chew protein HBN41_RS03180 ENOG4105C8Q Methyl-accepting chemotaxis HBN41_RS03185 ENOG4105CBS Chea signal transduction histidine kinase HBN41_RS03200 ENOG4107PEH Entericidin EcnA/B family HBN41_RS03210 ENOG4105WD1 Membrane HBN41_RS03215 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HBN41_RS03265 ENOG4105EM2 membrane HBN41_RS03270 ENOG4105C2C drug resistance transporter, Bcr CflA HBN41_RS03290 ENOG4105BZG amino acid carrier protein HBN41_RS03295 ENOG4105D78 K07001 NTE family protein HBN41_RS03300 ENOG4105C7B Threonine dehydratase HBN41_RS03345 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HBN41_RS03355 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HBN41_RS03365 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HBN41_RS03370 ENOG4105VQ7 Rod shape-determining protein MreD HBN41_RS03375 ENOG4108Z03 MAF-like protein HBN41_RS03380 ENOG4105C03 ribonuclease HBN41_RS03390 ENOG4105D8T Acyltransferase HBN41_RS03400 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HBN41_RS03410 ENOG4108X0B nad(p)h dehydrogenase (quinone) HBN41_RS03435 ENOG4105CF7 AraC family transcriptional regulator HBN41_RS03455 ENOG4105C85 amino acid HBN41_RS03460 ENOG4105C7F AcnD-accessory protein PrpF HBN41_RS03465 ENOG4105CTB Polyprenyl synthetase HBN41_RS03470 ENOG4105MSB protein, conserved in bacteria HBN41_RS03485 ENOG4105D78 K07001 NTE family protein HBN41_RS03505 ENOG4105DIJ Phosphoethanolamine transferase HBN41_RS03510 ENOG4105XJC Two component transcriptional regulator (Winged helix family HBN41_RS03515 ENOG4105DHQ Histidine kinase HBN41_RS03530 ENOG4108M0I Transcriptional regulator HBN41_RS03550 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HBN41_RS03570 ENOG4105K8R UPF0145 protein HBN41_RS03575 ENOG4105K8R UPF0145 protein HBN41_RS03580 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HBN41_RS03585 ENOG4105BZS acriflavin resistance protein HBN41_RS03590 ENOG4105C1P efflux transporter, rnd family, mfp subunit HBN41_RS03595 ENOG410841Q phosphoesterase PA-phosphatase related protein HBN41_RS03625 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HBN41_RS03640 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HBN41_RS03645 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HBN41_RS03650 ENOG4105KVH Transcriptional regulator HBN41_RS03660 ENOG4105CUB amino acid HBN41_RS03675 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HBN41_RS03680 ENOG41084BA UPF0250 protein HBN41_RS03685 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBN41_RS03720 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HBN41_RS03725 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HBN41_RS03735 ENOG4105E33 succinate dehydrogenase HBN41_RS03750 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HBN41_RS03755 ENOG4105C7S Dehydrogenase HBN41_RS03760 ENOG4107QN2 dihydrolipoyl dehydrogenase HBN41_RS03770 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HBN41_RS03780 ENOG4105CKW Inner membrane protein yedI HBN41_RS03785 ENOG4105CGZ zinc metallopeptidase HBN41_RS03790 ENOG4105EEQ Na H antiporter HBN41_RS03820 ENOG4105PNM synthesis protein HBN41_RS03835 ENOG41080TK Universal stress protein HBN41_RS03850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HBN41_RS03855 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HBN41_RS03870 ENOG4105HBR Rna-binding protein HBN41_RS03880 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HBN41_RS03885 ENOG4105EEI dihydropteroate synthase HBN41_RS03935 ENOG4105CSH Transporter HBN41_RS03940 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HBN41_RS03945 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HBN41_RS03960 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HBN41_RS03980 ENOG41080IJ Diacylglycerol kinase HBN41_RS03990 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HBN41_RS03995 ENOG4105BZS acriflavin resistance protein HBN41_RS04010 ENOG4105E4C Lytic transglycosylase catalytic HBN41_RS04030 ENOG4108RRZ Transcription elongation factor GreB HBN41_RS04045 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS04085 ENOG4105BZW Glycerate kinase HBN41_RS04090 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HBN41_RS04095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HBN41_RS04110 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HBN41_RS04120 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HBN41_RS04125 ENOG4105C85 amino acid HBN41_RS04135 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HBN41_RS04145 ENOG4105N14 lysine exporter protein LysE YggA HBN41_RS04150 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBN41_RS04155 ENOG4105BZJ Electron transfer flavoprotein HBN41_RS04160 ENOG4105C10 Electron transfer flavoprotein HBN41_RS04165 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBN41_RS04200 ENOG4107KET secretion protein, HlyD family HBN41_RS04235 ENOG4105D60 lipoprotein releasing system transmembrane protein HBN41_RS04240 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HBN41_RS04245 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HBN41_RS04255 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HBN41_RS04260 ENOG4107R6F Alpha Beta Hydrolase Fold protein HBN41_RS04265 ENOG4108V3E phosphoribosylglycinamide formyltransferase HBN41_RS04275 ENOG4105C02 permease HBN41_RS04325 ENOG4105KCK Peptidoglycan-associated lipoprotein HBN41_RS04330 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HBN41_RS04340 ENOG4105M8F Biopolymer transport protein exbD tolR HBN41_RS04345 ENOG4105E02 MotA TolQ exbB proton channel HBN41_RS04350 ENOG4107YD3 Thioesterase HBN41_RS04355 ENOG4105CH2 amidohydrolase HBN41_RS04375 ENOG4108ETH Formylglycinamide ribotide synthetase HBN41_RS04380 ENOG4105C2C drug resistance transporter, Bcr CflA HBN41_RS04390 ENOG4108UKI Enoyl-CoA hydratase HBN41_RS04405 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBN41_RS04420 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HBN41_RS04425 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HBN41_RS04440 ENOG4107R11 Transcriptional regulator HBN41_RS04445 ENOG4108IJ6 ABC transporter HBN41_RS04455 ENOG4108I5D sulfate abc transporter HBN41_RS04465 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HBN41_RS04470 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HBN41_RS04475 ENOG4105HHA aminodeoxychorismate lyase HBN41_RS04490 ENOG4108IYU L-aspartate oxidase HBN41_RS04495 ENOG4105C0H protease HBN41_RS04510 ENOG4105C3F Signal peptidase i HBN41_RS04525 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HBN41_RS04535 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HBN41_RS04540 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HBN41_RS04545 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HBN41_RS04550 ENOG4105EMU Dehydrogenase HBN41_RS04590 ENOG4105BZU Histidine kinase HBN41_RS04600 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HBN41_RS04610 ENOG4105DTR rard protein HBN41_RS04645 ENOG4107QS8 (LipO)protein HBN41_RS04650 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HBN41_RS04655 ENOG4105EA8 2-Nitropropane dioxygenase HBN41_RS04685 ENOG4107R8N Glycosyl transferase, family 2 HBN41_RS04700 ENOG4105CVP deoxyribo-dipyrimidine photolyase HBN41_RS04705 ENOG4108YZY peptidylprolyl cis-trans isomerase HBN41_RS04710 ENOG4105CEP NADH dehydrogenase HBN41_RS04715 ENOG4105DZ1 carboxypeptidase HBN41_RS04725 ENOG4105E9K Isocitrate dehydrogenase HBN41_RS04730 ENOG4108R99 pseudouridine synthase HBN41_RS04755 ENOG4105CBP Major Facilitator HBN41_RS04760 ENOG4105EGI Transcriptional regulator HBN41_RS04765 ENOG4108ETY sodium dicarboxylate symporter HBN41_RS04770 ENOG4105JAB phenazine biosynthesis protein, phzf family HBN41_RS04800 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HBN41_RS04815 ENOG4105D3G Pseudouridine synthase HBN41_RS04820 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HBN41_RS04835 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HBN41_RS04860 ENOG4108JPW Aminotransferase HBN41_RS04865 ENOG4105DY8 decarboxylase HBN41_RS04875 ENOG4105F7P transcriptional regulator AsnC family HBN41_RS04880 ENOG4107RA9 decarboxylase HBN41_RS04885 ENOG4105C85 amino acid HBN41_RS04890 ENOG4105CVA phosphate HBN41_RS04895 ENOG4105C8U phosphate abc transporter HBN41_RS04905 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HBN41_RS04910 ENOG4105ERU peptidase HBN41_RS04920 ENOG4105D5G Transposase HBN41_RS04930 ENOG4107QTF adenylosuccinate lyase HBN41_RS04950 ENOG4108Z0R Transferase HBN41_RS04955 ENOG4105DZ1 carboxypeptidase HBN41_RS04975 ENOG4108K5P (LipO)protein HBN41_RS04980 ENOG4105EJC lysr family transcriptional regulator HBN41_RS04985 ENOG4105DAN ATP-dependent protease HBN41_RS05000 ENOG4105DHU Bile acid HBN41_RS05020 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HBN41_RS05030 ENOG4105D22 carbon starvation protein HBN41_RS05035 ENOG4105VCD cytoplasmic protein HBN41_RS05070 ENOG4108K8K Transcriptional regulator HBN41_RS05085 ENOG4105C26 Dehydrogenase HBN41_RS05090 ENOG4105C85 amino acid HBN41_RS05095 ENOG4105ETT transcriptional Regulator, LysR family HBN41_RS05100 ENOG4105C94 Transporter HBN41_RS05105 ENOG4105C94 Transporter HBN41_RS05120 ENOG4107QZF nitrite reductase NADPH large subunit HBN41_RS05125 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HBN41_RS05155 ENOG41060M8 Pfam:PhdYeFM HBN41_RS05160 ENOG4107QNK )-transporter HBN41_RS05165 ENOG4107WEA mandelate racemase muconate lactonizing HBN41_RS05175 ENOG4105J7D transcriptional regulator HBN41_RS05195 ENOG4105C2I pirin domain protein HBN41_RS05205 ENOG4105WWK YheO domain protein HBN41_RS05220 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS05235 ENOG4108IPW abc transporter atp-binding protein HBN41_RS05255 ENOG4105C0W non-ribosomal peptide synthetase HBN41_RS05260 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HBN41_RS05265 ENOG4105WQI isochorismatase HBN41_RS05280 ENOG4105BZ1 (ABC) transporter HBN41_RS05305 ENOG4105E4F Isochorismate synthase HBN41_RS05320 ENOG4105NX3 Membrane HBN41_RS05345 ENOG4105EUJ GTP cyclohydrolase i HBN41_RS05355 ENOG4105C7W Xanthine dehydrogenase HBN41_RS05385 ENOG4105CD8 aminopeptidase N HBN41_RS05390 ENOG4105DDQ anthranilate synthase HBN41_RS05400 ENOG4105DUX Transporter HBN41_RS05415 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HBN41_RS05450 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBN41_RS05455 ENOG4107QNR UPF0135 protein HBN41_RS05460 ENOG4105C0H protease HBN41_RS05470 ENOG4105C6K Malic enzyme HBN41_RS05475 ENOG4105BZU Histidine kinase HBN41_RS05480 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HBN41_RS05485 ENOG4105SYT Methylenetetrahydrofolate reductase HBN41_RS05490 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HBN41_RS05505 ENOG4107QPN acyl-Coa dehydrogenase HBN41_RS05510 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HBN41_RS05515 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HBN41_RS05525 ENOG4107RNU major facilitator superfamily MFS_1 HBN41_RS05535 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBN41_RS05540 ENOG4105CE9 30S ribosomal protein S2 HBN41_RS05580 ENOG4105CVE Lytic murein transglycosylase HBN41_RS05585 ENOG4105CNI cell division protein FtsW HBN41_RS05600 ENOG4105E3A (ABC) transporter HBN41_RS05605 ENOG4105DA5 (ABC) transporter HBN41_RS05640 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HBN41_RS05650 ENOG4105ENT Efflux transporter rnd family, mfp subunit HBN41_RS05660 ENOG4105E89 ABC transporter HBN41_RS05665 ENOG4105DSP amino acid AbC transporter HBN41_RS05670 ENOG4106YG3 ABC transporter HBN41_RS05675 ENOG4108JEH abc transporter atp-binding protein HBN41_RS05685 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HBN41_RS05690 ENOG4105CFP Peptidase U32 HBN41_RS05695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBN41_RS05700 ENOG4105JAB phenazine biosynthesis protein, phzf family HBN41_RS05705 ENOG4105DP0 ferredoxin-NADP reductase HBN41_RS05710 ENOG4108R96 Methyltransferase, YaeB family HBN41_RS05720 ENOG4107QHF type ii secretion system protein e HBN41_RS05730 ENOG4105XJC Two component transcriptional regulator (Winged helix family HBN41_RS05735 ENOG4105DHQ Histidine kinase HBN41_RS05745 ENOG4105M6F mutator MutT protein HBN41_RS05755 ENOG4105BZ4 penicillin-binding protein HBN41_RS05760 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HBN41_RS05765 ENOG4105VUT cytoplasmic protein HBN41_RS05770 ENOG4107QYG anthranilate phosphoribosyltransferase HBN41_RS05775 ENOG4105CK2 sodium dicarboxylate symporter HBN41_RS05780 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS05785 ENOG4105NIV Esterase HBN41_RS05790 ENOG4105CQC Prephenate dehydratase HBN41_RS05795 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HBN41_RS05805 ENOG4105CIN aminoacyl-histidine dipeptidase HBN41_RS05810 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HBN41_RS05840 ENOG4105M08 Membrane HBN41_RS05845 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBN41_RS05855 ENOG4105VEQ Cold shock protein HBN41_RS05860 ENOG4105C1J atp-dependent rna helicase HBN41_RS05870 ENOG41069NU Nitroreductase HBN41_RS05905 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HBN41_RS05920 ENOG4105C5I Dehydrogenase HBN41_RS05925 ENOG4105ERG peptidase m48, ste24p HBN41_RS05930 ENOG4105KTH gatB Yqey HBN41_RS05960 ENOG4105D9P serine threonine protein kinase HBN41_RS05985 ENOG4105EVZ LysR family transcriptional regulator HBN41_RS05990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBN41_RS05995 ENOG4105C26 Dehydrogenase HBN41_RS06030 ENOG4105H4F exported protein HBN41_RS06060 ENOG4105D6U Sodium Glutamate Symporter HBN41_RS06070 ENOG4105JXH GntR family transcriptional regulator HBN41_RS06120 ENOG4105CSH Transporter HBN41_RS06140 ENOG4105CEB Aspartate aminotransferase HBN41_RS06155 ENOG4105F1S paraquat-inducible protein a HBN41_RS06160 ENOG4105DY2 Paraquat-inducible protein b HBN41_RS06180 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HBN41_RS06235 ENOG4108BUD transposase HBN41_RS06250 ENOG4105CK2 sodium dicarboxylate symporter HBN41_RS06260 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HBN41_RS06265 ENOG4108UMI ABC transporter, permease HBN41_RS06270 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBN41_RS06280 ENOG4105C12 Phosphoribosylglycinamide synthetase HBN41_RS06285 ENOG4105DC1 bifunctional purine biosynthesis protein purh HBN41_RS06290 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HBN41_RS06340 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HBN41_RS06345 ENOG4105CDU Replicative dna helicase HBN41_RS06370 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HBN41_RS06375 ENOG4105CCU oxidase (Subunit III) HBN41_RS06380 ENOG4105BZ9 Cytochrome C oxidase, subunit I HBN41_RS06385 ENOG4105E2S oxidase) subunit II HBN41_RS06410 ENOG4107BJW polysaccharide deacetylase HBN41_RS06415 ENOG4105CND Glycosyl transferase, family 2 HBN41_RS06430 ENOG4105DEN Luciferase family HBN41_RS06445 ENOG4105CC0 LysR family Transcriptional regulator HBN41_RS06460 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HBN41_RS06465 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HBN41_RS06470 ENOG4105GVF (ABC) transporter HBN41_RS06485 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS06495 ENOG4108MEJ flavin reductase domain protein HBN41_RS06500 ENOG4105D06 uba thif-type nad fad binding protein HBN41_RS06520 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HBN41_RS06525 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HBN41_RS06535 ENOG4105C08 Histidine kinase HBN41_RS06540 ENOG4105EEX Two component transcriptional regulator (Winged helix family HBN41_RS06545 ENOG4105CFQ glutamine synthetase HBN41_RS06560 ENOG4107S74 Lysophospholipid transporter LplT HBN41_RS06565 ENOG4105CFU surface antigen HBN41_RS06580 ENOG4107QIJ Aconitate hydratase 2 HBN41_RS06590 ENOG4105EYW Ion transport protein HBN41_RS06595 ENOG4105F27 Major Facilitator HBN41_RS06610 ENOG4105DZ2 Transcriptional regulator HBN41_RS06645 ENOG4105K8N protein family UPF0079, ATPase HBN41_RS06650 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HBN41_RS06660 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HBN41_RS06665 ENOG4108TZV Membrane HBN41_RS06670 ENOG4108RCM Nitroreductase HBN41_RS06680 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HBN41_RS06690 ENOG4105CX6 glutaminyL-tRNA synthetase HBN41_RS06695 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HBN41_RS06700 ENOG4107FQ9 ethanolamine ammonia-lyase HBN41_RS06705 ENOG4105CPD ethanolamine ammonia-lyase HBN41_RS06710 ENOG4107R55 ethanolamine transporter HBN41_RS06720 ENOG4107RR1 TRANSCRIPTIONal HBN41_RS06730 ENOG4105C0A alcohol dehydrogenase HBN41_RS06735 ENOG4107QUV Domain protein HBN41_RS06745 ENOG4105F4I Transcriptional regulator HBN41_RS06765 ENOG4105CD8 aminopeptidase N HBN41_RS06795 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HBN41_RS06800 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS06810 ENOG4105R8C Transcriptional regulator HBN41_RS06820 ENOG4105CUY Mechanosensitive ion channel HBN41_RS06855 ENOG4105CNM Receptor HBN41_RS06875 ENOG4105C5H ABC transporter HBN41_RS06880 ENOG41081QV Universal stress protein HBN41_RS06905 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HBN41_RS06915 ENOG4105DKK Benzoate HBN41_RS06920 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS06925 ENOG4108NIW Leucine export protein LeuE HBN41_RS06935 ENOG4105C5Q Transcriptional regulator HBN41_RS06945 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS06950 ENOG4105CHR reductase HBN41_RS06975 ENOG4107QMP dna polymerase iii subunits gamma and tau HBN41_RS06980 ENOG4105HSS phospholipase C HBN41_RS06990 ENOG4105C0A alcohol dehydrogenase HBN41_RS07020 ENOG4105CBC glutamate synthase HBN41_RS07315 ENOG4105DR5 peptidase HBN41_RS07380 ENOG4105D8G Major Facilitator superfamily HBN41_RS07390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBN41_RS07395 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HBN41_RS07420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBN41_RS07430 ENOG4107QZF nitrite reductase NADPH large subunit HBN41_RS07435 ENOG4108IFG nitrite reductase, (NAD(P)H) HBN41_RS07450 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HBN41_RS07455 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBN41_RS07470 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBN41_RS07475 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBN41_RS07485 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBN41_RS07490 ENOG4105T38 integral membrane protein HBN41_RS07510 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HBN41_RS07515 ENOG4105CMR udp-glucose 4-epimerase HBN41_RS07580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HBN41_RS07585 ENOG4105CUX Signal transduction histidine kinase HBN41_RS07605 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HBN41_RS07610 ENOG4105KNE Phosphatidate cytidylyltransferase HBN41_RS07620 ENOG4105DZP Membrane-associated zinc metalloprotease HBN41_RS07645 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HBN41_RS07660 ENOG4105Y3E Modulates RecA activity (By similarity) HBN41_RS07670 ENOG4105VEJ Heat shock protein HBN41_RS07675 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HBN41_RS07700 ENOG4105F7P transcriptional regulator AsnC family HBN41_RS07710 ENOG4105C85 amino acid HBN41_RS07725 ENOG4105CHH sulfate transporter HBN41_RS07730 ENOG4108RAV Conserved protein HBN41_RS07735 ENOG4105D8V Glucose sorbosone dehydrogenase HBN41_RS07745 ENOG4105BZU Histidine kinase HBN41_RS07765 ENOG4105DM4 PTS System HBN41_RS07770 ENOG4105DE4 1-phosphofructokinase HBN41_RS07775 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HBN41_RS07800 ENOG4105CWM branched-chain amino acid transport system II carrier protein HBN41_RS07805 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBN41_RS07810 ENOG4105CC0 LysR family Transcriptional regulator HBN41_RS07820 ENOG4105M2J Glutaredoxin HBN41_RS07825 ENOG4105C8Y Acetylornithine aminotransferase HBN41_RS07830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HBN41_RS07855 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HBN41_RS07865 ENOG41068P6 UPF0319 protein HBN41_RS07885 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBN41_RS07890 ENOG4105C4M (Ubiquinol oxidase) subunit I HBN41_RS07900 ENOG4105PV3 Inner membrane protein yqiJ HBN41_RS07915 ENOG4105E0K tonB-dependent siderophore receptor HBN41_RS07925 ENOG4105HDD phospholipase HBN41_RS07930 ENOG4105CZN Potassium uptake protein HBN41_RS07940 ENOG4105C7B Threonine dehydratase HBN41_RS07970 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HBN41_RS07975 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HBN41_RS07985 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HBN41_RS08000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HBN41_RS08045 ENOG4107VMU Membrane HBN41_RS08050 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HBN41_RS08060 ENOG4107QP7 CoA-transferase subunit A HBN41_RS08065 ENOG4107QNJ CoA-transferase subunit B HBN41_RS08070 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS08075 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HBN41_RS08080 ENOG4105F2Z 3-oxoadipate enol-lactonase HBN41_RS08085 ENOG4105D2S major facilitator superfamily HBN41_RS08090 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HBN41_RS08095 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HBN41_RS08100 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HBN41_RS08105 ENOG4105FF2 Type I DHQase HBN41_RS08110 ENOG4106JPM 3-dehydroshikimate dehydratase HBN41_RS08115 ENOG4105TW1 Carbohydrate-selective porin OprB HBN41_RS08120 ENOG4105DZG Dehydrogenase HBN41_RS08130 ENOG4105MD1 YeeE YedE family protein HBN41_RS08145 ENOG4107HP6 Transcriptional regulator HBN41_RS08150 ENOG4108PTX LysR family Transcriptional regulator HBN41_RS08155 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS08180 ENOG41080HT Transcriptional regulator, arsr family HBN41_RS08190 ENOG4105EZE Cupin 4 family protein HBN41_RS08195 ENOG4108UHJ MAF-like protein HBN41_RS08215 ENOG4105D2N Aldolase HBN41_RS08220 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HBN41_RS08225 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HBN41_RS08230 ENOG4105EHM Aminoglycoside phosphotransferase HBN41_RS08235 ENOG4108S0S Nucleotidyl transferase HBN41_RS08245 ENOG4107QJE Chromosome Partitioning Protein HBN41_RS08250 ENOG4105FA0 parb-like partition protein HBN41_RS08265 ENOG4105BZ1 (ABC) transporter HBN41_RS08270 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HBN41_RS08280 ENOG4107QRG dna polymerase iii HBN41_RS08290 ENOG4105F8V Hydrolase, tatD family HBN41_RS08315 ENOG4108RTD type II secretion system protein K HBN41_RS08335 ENOG4108Z6B deaminase HBN41_RS08350 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HBN41_RS08355 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HBN41_RS08375 ENOG4107RN6 Monooxygenase HBN41_RS08385 ENOG4105D6Z AFG1 family ATPase HBN41_RS08390 ENOG4107QP3 malate synthase g HBN41_RS08400 ENOG4105SG9 biopolymer transport protein, ExbD HBN41_RS08440 ENOG4105DGW oligopeptidase A HBN41_RS08450 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HBN41_RS08470 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HBN41_RS08485 ENOG4105K4T epimerase HBN41_RS08490 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HBN41_RS08510 ENOG4108JA2 transcriptioN-repair coupling factor HBN41_RS08520 ENOG4105F8J Adenylate Guanylate cyclase HBN41_RS08525 ENOG4108ZIT Ferredoxin, 2FE-2S HBN41_RS08540 ENOG4108Z4V iron-sulfur cluster assembly HBN41_RS08545 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HBN41_RS08555 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HBN41_RS08570 ENOG4105K70 DNA-binding protein HBN41_RS08575 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HBN41_RS08580 ENOG4105E7U AraC family transcriptional regulator HBN41_RS08585 ENOG4105EEF Alkane 1-monooxygenase HBN41_RS08590 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS08595 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS08610 ENOG4108Z66 YbaK ebsC protein HBN41_RS08630 ENOG4105DUU IucA IucC family protein HBN41_RS08635 ENOG4105DJU Siderophore biosynthesis protein HBN41_RS08685 ENOG4108YZT Adenosylcobinamide kinase HBN41_RS08690 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HBN41_RS08710 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HBN41_RS08715 ENOG4107TSN permease HBN41_RS08735 ENOG4105CNM Receptor HBN41_RS08740 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HBN41_RS08755 ENOG4105CJ1 ABC, transporter HBN41_RS08760 ENOG4107QWP ABC-2 type transporter HBN41_RS08765 ENOG4107QWP ABC-2 type transporter HBN41_RS08790 ENOG4105K59 histidine triad (HIT) protein HBN41_RS08820 ENOG4105F2W methyltransferase HBN41_RS08830 ENOG4105C28 cystathionine HBN41_RS08845 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HBN41_RS08890 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HBN41_RS08895 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HBN41_RS08905 ENOG4105BZU Histidine kinase HBN41_RS08920 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HBN41_RS08925 ENOG4107R0V Pyruvate dehydrogenase HBN41_RS08930 ENOG4105CPP Dehydrogenase, E1 component HBN41_RS08945 ENOG4105CHR reductase HBN41_RS08955 ENOG4105FFC UPF0187 protein HBN41_RS08965 ENOG4107QPB Beta-lactamase domain protein HBN41_RS08975 ENOG4108VCT Sulfite exporter TauE/SafE HBN41_RS08990 ENOG4105UEI Transcriptional Regulator AraC Family HBN41_RS08995 ENOG4105KVH Transcriptional regulator HBN41_RS09000 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HBN41_RS09025 ENOG4106FTQ Taurine ABC transporter, periplasmic HBN41_RS09030 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HBN41_RS09050 ENOG4105CSH Transporter HBN41_RS09060 ENOG4108IJ0 Aspartate ammonia-lyase HBN41_RS09075 ENOG4107YNJ LysR family Transcriptional regulator HBN41_RS09085 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS09090 ENOG4105CRW Short chain fatty acid transporter HBN41_RS09095 ENOG4107QNJ CoA-transferase subunit B HBN41_RS09105 ENOG4108M0I Transcriptional regulator HBN41_RS09115 ENOG4105CY2 Citrate transporter HBN41_RS09120 ENOG4105DTD Dehydrogenase HBN41_RS09130 ENOG4105CF7 AraC family transcriptional regulator HBN41_RS09145 ENOG4105CHR reductase HBN41_RS09170 ENOG4105F57 Anthranilate dioxygenase reductase HBN41_RS09175 ENOG4108YS2 small subunit HBN41_RS09180 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HBN41_RS09185 ENOG4105F4R Transcriptional regulator mode HBN41_RS09190 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HBN41_RS09195 ENOG4105E0C molybdate abc transporter HBN41_RS09200 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HBN41_RS09205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HBN41_RS09210 ENOG4105WQI isochorismatase HBN41_RS09220 ENOG4107T31 5'-nucleotidase HBN41_RS09255 ENOG4108IGT Dipeptidase HBN41_RS09275 ENOG4107RZC phospholipase d HBN41_RS09335 ENOG4105X0I Fimbrial HBN41_RS09355 ENOG4105CJP fad dependent oxidoreductase HBN41_RS09375 ENOG4105CT3 Monooxygenase HBN41_RS09385 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HBN41_RS09390 ENOG4105BZS acriflavin resistance protein HBN41_RS09395 ENOG4105C1P efflux transporter, rnd family, mfp subunit HBN41_RS09400 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBN41_RS09405 ENOG4105E0F Histidine kinase HBN41_RS09410 ENOG4108821 RND type efflux pump HBN41_RS09415 ENOG4108R6W Transcriptional regulator, ARAC family HBN41_RS09430 ENOG4108BAS reductase HBN41_RS09480 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HBN41_RS09520 ENOG4108UAJ Transcriptional regulator HBN41_RS09600 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HBN41_RS09620 ENOG4105E0A ABC, transporter HBN41_RS09625 ENOG4105EHG Permease protein HBN41_RS09635 ENOG4105DQ4 alcohol dehydrogenase HBN41_RS09650 ENOG4105CF7 AraC family transcriptional regulator HBN41_RS09655 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBN41_RS09665 ENOG4105EXW epimerase dehydratase HBN41_RS09670 ENOG4105DDW LysR family Transcriptional regulator HBN41_RS09685 ENOG4105CZJ Aldehyde dehydrogenase HBN41_RS09700 ENOG4105CW7 secretion protein, HlyD family HBN41_RS09720 ENOG4105JSC dimethylmenaquinone methyltransferase HBN41_RS09750 ENOG4106P55 Transcriptional regulator HBN41_RS09795 ENOG4105CKT filamentous hemagglutinin HBN41_RS09800 ENOG4105D5K Hemolysin activator protein HBN41_RS09810 ENOG4105CH2 amidohydrolase HBN41_RS09820 ENOG4105CKD glutathione-regulated potassium-efflux system protein HBN41_RS09825 ENOG4105D8V Glucose sorbosone dehydrogenase HBN41_RS09830 ENOG4105EJC lysr family transcriptional regulator HBN41_RS09835 ENOG4105CHJ isochorismatase hydrolase HBN41_RS09845 ENOG4107Z3H Transcriptional regulator, TetR family HBN41_RS09875 ENOG4105NAE bifunctional deaminase-reductase domain protein HBN41_RS09885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HBN41_RS09890 ENOG4105K56 Transcriptional regulator HBN41_RS09910 ENOG4105CH6 catalase HBN41_RS09925 ENOG4107RGH Aldehyde dehydrogenase HBN41_RS09940 ENOG41062QD Membrane HBN41_RS09950 ENOG4108JU7 Transcriptional regulator HBN41_RS09955 ENOG4105CHR reductase HBN41_RS09960 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS09980 ENOG4105CZJ Aldehyde dehydrogenase HBN41_RS10000 ENOG4107EJG GntR family transcriptional regulator HBN41_RS10010 ENOG4108KB2 LysR family Transcriptional regulator HBN41_RS10015 ENOG4105DTQ mandelate racemase muconate lactonizing HBN41_RS10020 ENOG4105NN7 muconolactone delta-isomerase HBN41_RS10030 ENOG4107QP7 CoA-transferase subunit A HBN41_RS10035 ENOG4107QNJ CoA-transferase subunit B HBN41_RS10040 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS10045 ENOG4105F2Z 3-oxoadipate enol-lactonase HBN41_RS10055 ENOG4105C26 Dehydrogenase HBN41_RS10065 ENOG4105F11 amine oxidase HBN41_RS10085 ENOG4105CHR reductase HBN41_RS10095 ENOG4105FUY alpha subunit HBN41_RS10115 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HBN41_RS10125 ENOG4105DNH Major Facilitator HBN41_RS10150 ENOG4105XPP Protein of unknown function (DUF1275) HBN41_RS10155 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HBN41_RS10160 ENOG4105BZ1 (ABC) transporter HBN41_RS10170 ENOG4108ZX5 transcriptional regulator HBN41_RS10180 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HBN41_RS10185 ENOG4105CK7 Sodium proline symporter HBN41_RS10190 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS10195 ENOG4105C26 Dehydrogenase HBN41_RS10200 ENOG4105YGK Pfam:UPF0157 HBN41_RS10215 ENOG4108T58 Mg2 transport protein CorA HBN41_RS10225 ENOG4108YYC ycei family HBN41_RS10235 ENOG4105CV1 Transketolase (EC 2.2.1.1) HBN41_RS10260 ENOG4108HWY Beta-lactamase HBN41_RS10280 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HBN41_RS10285 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HBN41_RS10305 ENOG4105X0I Fimbrial HBN41_RS10310 ENOG4105GQR Chaperone HBN41_RS10335 ENOG4108IPJ Membrane HBN41_RS10345 ENOG4105ETS cytosine purines uracil thiamine allantoin HBN41_RS10355 ENOG4105CC0 LysR family Transcriptional regulator HBN41_RS10375 ENOG41067SE Tetr family transcriptional regulator HBN41_RS10390 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS10400 ENOG4105CDA abc transporter atp-binding protein HBN41_RS10405 ENOG4105DRP amino acid AbC transporter HBN41_RS10410 ENOG4105EAD ABC transporter HBN41_RS10425 ENOG4107T8P acyl-Coa dehydrogenase HBN41_RS10440 ENOG4105D01 (LipO)protein HBN41_RS10445 ENOG4105D01 (LipO)protein HBN41_RS10450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBN41_RS10455 ENOG4108UMI ABC transporter, permease HBN41_RS10460 ENOG4105C3G gtp-binding protein HBN41_RS10485 ENOG4108UMN azlc family HBN41_RS10490 ENOG4105ZED uncharacterized protein ygaH HBN41_RS10520 ENOG4105E7U AraC family transcriptional regulator HBN41_RS10525 ENOG4108V06 Glutathione peroxidase HBN41_RS10535 ENOG4105CHM Aminotransferase HBN41_RS10550 ENOG4105C0B DNA polymerase III (alpha subunit) HBN41_RS10575 ENOG4108JU3 Alkyl hydroperoxide reductase HBN41_RS10590 ENOG4108KB2 LysR family Transcriptional regulator HBN41_RS10595 ENOG4105D6J arsenicaL-resistance protein HBN41_RS10600 ENOG41082YX Transcriptional regulator, arsr family HBN41_RS10615 ENOG4105CPN adenine deaminase HBN41_RS10625 ENOG4105CBN LysR family transcriptional regulator HBN41_RS10635 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HBN41_RS10650 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HBN41_RS10655 ENOG4108IY8 ABC, transporter HBN41_RS10660 ENOG4106FTQ Taurine ABC transporter, periplasmic HBN41_RS10670 ENOG4105C54 Major Facilitator superfamily HBN41_RS10690 ENOG4105C4M (Ubiquinol oxidase) subunit I HBN41_RS10695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBN41_RS10705 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBN41_RS10710 ENOG4108K70 Transcriptional regulator HBN41_RS10725 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HBN41_RS10730 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HBN41_RS10745 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HBN41_RS10750 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HBN41_RS10760 ENOG4105DXI Major Facilitator superfamily HBN41_RS10780 ENOG41067MG lrgb family HBN41_RS10785 ENOG4105VAW lrga family HBN41_RS10790 ENOG4105CMU LysR family (Transcriptional regulator HBN41_RS10795 ENOG4108SHQ Glutathione S-transferase HBN41_RS10800 ENOG4105CYM Glutathione S-transferase HBN41_RS10805 ENOG4105CBN LysR family transcriptional regulator HBN41_RS10810 ENOG4105CHR reductase HBN41_RS10820 ENOG4105D7W serine acetyltransferase HBN41_RS10825 ENOG4105ESN nucleotide-binding protein HBN41_RS10830 ENOG4105C9B Cysteine desulfurase HBN41_RS10840 ENOG4105CCF Lysine exporter protein (Lyse ygga) HBN41_RS10845 ENOG4105EXG Transcriptional regulator HBN41_RS10855 ENOG4105CT1 (ABC) transporter HBN41_RS10860 ENOG4107RP9 extracellular solute-binding protein, family 3 HBN41_RS10865 ENOG4105CDA abc transporter atp-binding protein HBN41_RS10870 ENOG4108HW4 amino acid AbC transporter HBN41_RS10875 ENOG4105EAD ABC transporter HBN41_RS10890 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HBN41_RS10895 ENOG4105BZU Histidine kinase HBN41_RS10905 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS10915 ENOG4105KT5 UmuD protein HBN41_RS10935 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HBN41_RS10985 ENOG4105HEI LysR family (Transcriptional regulator HBN41_RS11005 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS11010 ENOG4105R8C Transcriptional regulator HBN41_RS11015 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS11020 ENOG4107QX3 carboxylase HBN41_RS11025 ENOG4105E39 Enoyl-CoA hydratase HBN41_RS11040 ENOG4105CC0 LysR family Transcriptional regulator HBN41_RS11055 ENOG4105CSU acyl-Coa dehydrogenase HBN41_RS11075 ENOG4107QNJ CoA-transferase subunit B HBN41_RS11080 ENOG4107QP7 CoA-transferase subunit A HBN41_RS11085 ENOG4107RGD Major Facilitator superfamily HBN41_RS11090 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS11095 ENOG4105E39 Enoyl-CoA hydratase HBN41_RS11100 ENOG4105CHR reductase HBN41_RS11105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBN41_RS11110 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS11120 ENOG4105EQ0 Major Facilitator superfamily HBN41_RS11125 ENOG4105EA8 2-Nitropropane dioxygenase HBN41_RS11130 ENOG4108UKI Enoyl-CoA hydratase HBN41_RS11145 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS11150 ENOG4107RGD Major Facilitator superfamily HBN41_RS11155 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HBN41_RS11160 ENOG4107STF Involved in phosphonate degradation (By similarity) HBN41_RS11170 ENOG4107RCV ABC transporter, permease HBN41_RS11175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBN41_RS11180 ENOG4105C4Y ABC transporter HBN41_RS11190 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HBN41_RS11195 ENOG4107HP6 Transcriptional regulator HBN41_RS11205 ENOG4105HEI LysR family (Transcriptional regulator HBN41_RS11210 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HBN41_RS11215 ENOG4105C26 Dehydrogenase HBN41_RS11225 ENOG4105ETS cytosine purines uracil thiamine allantoin HBN41_RS11235 ENOG4105C26 Dehydrogenase HBN41_RS11255 ENOG4105F6A helicase HBN41_RS11265 ENOG4108HWY Beta-lactamase HBN41_RS11280 ENOG4105MXW flavin reductase domain protein, FMN-binding HBN41_RS11285 ENOG4108MXF Alpha Beta Hydrolase HBN41_RS11305 ENOG4105CPW cytochrome b561 HBN41_RS11310 ENOG4107VGR Catalase HBN41_RS11345 ENOG4107YAU phenylacetic acid degradation protein HBN41_RS11355 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HBN41_RS11360 ENOG4105DZS Phenylacetate-CoA ligase HBN41_RS11365 ENOG4105CHU acetyl-coa acetyltransferase HBN41_RS11370 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBN41_RS11375 ENOG4108UKI Enoyl-CoA hydratase HBN41_RS11380 ENOG4105E39 Enoyl-CoA hydratase HBN41_RS11385 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HBN41_RS11390 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HBN41_RS11395 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HBN41_RS11400 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HBN41_RS11405 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HBN41_RS11410 ENOG4105DXM phenylacetic acid degradation protein HBN41_RS11415 ENOG4105EJQ L-serine dehydratase HBN41_RS11420 ENOG4107QTZ amino acid HBN41_RS11425 ENOG4105CZJ Aldehyde dehydrogenase HBN41_RS11450 ENOG4105MWK D-amino acid dehydrogenase, small subunit HBN41_RS11470 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBN41_RS11480 ENOG4108Z4X TRANSCRIPTIONal HBN41_RS11495 ENOG4105WPN DNA integration recombination invertion protein HBN41_RS11510 ENOG4105DJ2 Major Facilitator Superfamily HBN41_RS11515 ENOG4107Y2X deaminase HBN41_RS11525 ENOG4105EMY transcriptional regulator HBN41_RS11555 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HBN41_RS11635 ENOG4108HW3 (ABC) transporter HBN41_RS11645 ENOG4105MRR Transcriptional regulator (By similarity) HBN41_RS11665 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HBN41_RS11670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBN41_RS11685 ENOG4105E2A Dehydrogenase HBN41_RS11695 ENOG4105R8C Transcriptional regulator HBN41_RS11715 ENOG4107R4J Chloride channel HBN41_RS11720 ENOG4108JIK carboxylase HBN41_RS11740 ENOG4105C5A transporter HBN41_RS11745 ENOG4108WAV Transcriptional regulator HBN41_RS11760 ENOG4105CNA YD repeat protein HBN41_RS11795 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HBN41_RS11815 ENOG4105D2S major facilitator superfamily HBN41_RS11825 ENOG4105D1S lipid A biosynthesis HBN41_RS11830 ENOG4105BZU Histidine kinase HBN41_RS11835 ENOG4107AQZ Membrane HBN41_RS11855 ENOG4108Z4U Ferredoxin HBN41_RS11895 ENOG4105DFG type I secretion outer membrane protein HBN41_RS11905 ENOG4108IUZ ABC transporter HBN41_RS11910 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HBN41_RS11925 ENOG4105C2X Arabinose 5-phosphate isomerase HBN41_RS11990 ENOG4105II7 pyrroline-5-carboxylate reductase HBN41_RS12000 ENOG4105VEQ Cold shock protein HBN41_RS12005 ENOG410829K Lysine exporter protein (Lyse ygga) HBN41_RS12040 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HBN41_RS12090 ENOG4108KB2 LysR family Transcriptional regulator HBN41_RS12095 ENOG4105FUY alpha subunit HBN41_RS12100 ENOG4108UKV benzoate 1,2-dioxygenase HBN41_RS12105 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HBN41_RS12110 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HBN41_RS12115 ENOG4105DKK Benzoate HBN41_RS12120 ENOG4105D2S major facilitator superfamily HBN41_RS12135 ENOG4105CQ7 ATP-dependent helicase HBN41_RS12140 ENOG4105D3R alkyl hydroperoxide reductase HBN41_RS12150 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HBN41_RS12160 ENOG4108JU3 Alkyl hydroperoxide reductase HBN41_RS12170 ENOG4108K3A Glutathione S-transferase HBN41_RS12180 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HBN41_RS12185 ENOG4108TGY Glutathione S-transferase HBN41_RS12195 ENOG4108ZG0 Ompa motb domain protein HBN41_RS12200 ENOG4105CD3 dihydroorotase HBN41_RS12230 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HBN41_RS12245 ENOG4108UKZ OsmC family HBN41_RS12250 ENOG4107RYR Transcriptional regulator, Crp Fnr family HBN41_RS12260 ENOG4105CPC Aldo Keto reductase HBN41_RS12275 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HBN41_RS12285 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HBN41_RS12295 ENOG4105CFH Aspartokinase HBN41_RS12305 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HBN41_RS12315 ENOG4105CPW cytochrome b561 HBN41_RS12320 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HBN41_RS12325 ENOG4105C7N Xanthine uracil vitamin C permease HBN41_RS12335 ENOG4105F95 Monooxygenase HBN41_RS12360 ENOG4108BUD transposase HBN41_RS12375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HBN41_RS12395 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HBN41_RS12415 ENOG4108JQ5 ABC transporter HBN41_RS12420 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HBN41_RS12425 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HBN41_RS12435 ENOG4105E9H Lytic Murein transglycosylase HBN41_RS12435 ENOG4105E9H Lytic Murein transglycosylase HBN41_RS12440 ENOG4107RZZ dna polymerase iii epsilon subunit HBN41_RS12450 ENOG4105E09 nadh pyrophosphatase HBN41_RS12460 ENOG4105W4M Transport-associated protein HBN41_RS12470 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HBN41_RS12480 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HBN41_RS12485 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HBN41_RS12505 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HBN41_RS12510 ENOG4105D0A hydroxylase HBN41_RS12515 ENOG4107RAQ aminopeptidase HBN41_RS12550 ENOG4105DIJ Phosphoethanolamine transferase HBN41_RS12595 ENOG4105DR5 peptidase HBN41_RS13025 ENOG4105EFC phage portal protein HK97 family HBN41_RS13120 ENOG4105CDU Replicative dna helicase HBN41_RS13135 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HBN41_RS13190 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HBN41_RS13215 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HBN41_RS13225 ENOG4105D82 Glutamate dehydrogenase HBN41_RS13230 ENOG4108R3D Electron transport complex HBN41_RS13235 ENOG4105CSM endonuclease III HBN41_RS13260 ENOG4105CJN penicillin-binding protein HBN41_RS13265 ENOG4106H78 methyltransferase HBN41_RS13280 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HBN41_RS13290 ENOG4105CQM Urea amidohydrolase subunit alpha HBN41_RS13320 ENOG4107RET Isocitrate lyase HBN41_RS13330 ENOG4105C37 (CBS) domain HBN41_RS13335 ENOG4105D4T Citrate transporter HBN41_RS13350 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HBN41_RS13370 ENOG4108MRJ HBN41_RS13390 ENOG4105VCQ rubredoxin HBN41_RS13395 ENOG4107QZF nitrite reductase NADPH large subunit HBN41_RS13405 ENOG4105C5Q Transcriptional regulator HBN41_RS13425 ENOG4107U91 Rhomboid family HBN41_RS13430 ENOG4105CV6 ABC transporter, permease HBN41_RS13435 ENOG4108I0Y (ABC) transporter HBN41_RS13440 ENOG4108UJV acyl-CoA thioesterase i HBN41_RS13460 ENOG4107RNH Outer membrane receptor FepA HBN41_RS13475 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HBN41_RS13480 ENOG4105E6M Sulphatase-modifying factor protein HBN41_RS13500 ENOG4105CJ3 phosphate transporter HBN41_RS13505 ENOG4105C3R Methionine synthase HBN41_RS13520 ENOG4105CSP Major Facilitator Superfamily HBN41_RS13530 ENOG4108PZW LysR family Transcriptional regulator HBN41_RS13540 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HBN41_RS13545 ENOG4105EU0 Major facilitator Superfamily HBN41_RS13550 ENOG4108R6W Transcriptional regulator, ARAC family HBN41_RS13555 ENOG4105CSV Glutaminase HBN41_RS13560 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HBN41_RS13565 ENOG4105CSH Transporter HBN41_RS13575 ENOG4105C7K acetolactate synthase HBN41_RS13590 ENOG4105CHR reductase HBN41_RS13595 ENOG4108MXF Alpha Beta Hydrolase HBN41_RS13605 ENOG4105DJB Major Facilitator Superfamily HBN41_RS13610 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HBN41_RS13620 ENOG4105CHR reductase HBN41_RS13640 ENOG41069M3 Transcriptional regulator HBN41_RS13655 ENOG4106YT9 Enoyl-CoA hydratase HBN41_RS13665 ENOG4105CND Glycosyl transferase, family 2 HBN41_RS13670 ENOG4107BJW polysaccharide deacetylase HBN41_RS13680 ENOG4108VWS Yaeq family HBN41_RS13690 ENOG4105CKI cobalamin synthesis protein HBN41_RS13700 ENOG4108S4H thioesterase Superfamily protein HBN41_RS13710 ENOG4105C94 Transporter HBN41_RS13715 ENOG4105C94 Transporter HBN41_RS13720 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HBN41_RS13745 ENOG4107QK5 Homocysteine s-methyltransferase HBN41_RS13750 ENOG4105D5Q Arginine ornithine antiporter HBN41_RS13775 ENOG4108YNN Heme oxygenase HBN41_RS13805 ENOG4108SF5 RNA Polymerase HBN41_RS13815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBN41_RS13820 ENOG4105C54 Major Facilitator superfamily HBN41_RS13840 ENOG4105F8V Hydrolase, tatD family HBN41_RS13875 ENOG4108UUM single-stranded DNA-binding protein HBN41_RS13930 ENOG4105DFP Integrase HBN41_RS14025 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBN41_RS14065 ENOG4105K4U addiction module toxin, RelE StbE family HBN41_RS14350 ENOG41083X2 DNA polymerase III, epsilon subunit HBN41_RS14420 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HBN41_RS14425 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBN41_RS14430 ENOG4105CW7 secretion protein, HlyD family HBN41_RS14435 ENOG4108VUY thioesterase Superfamily protein HBN41_RS14440 ENOG4105D52 delta-aminolevulinic acid dehydratase HBN41_RS14445 ENOG4105MWK D-amino acid dehydrogenase, small subunit HBN41_RS14450 ENOG4105ECP epimerase HBN41_RS14470 ENOG4107RH8 nuclease SbcCD subunit D HBN41_RS14475 ENOG4105EYH Exonuclease HBN41_RS14480 ENOG4105DFA alanine racemase domain protein HBN41_RS14485 ENOG4105CZX twitching motility protein HBN41_RS14490 ENOG4105CZX twitching motility protein HBN41_RS14495 ENOG41090R7 Ferric uptake HBN41_RS14520 ENOG4105E7A Glutamine amidotransferase HBN41_RS14535 ENOG4107QKV phosphomannomutase HBN41_RS14545 ENOG4105C4R Atp-dependent dna helicase HBN41_RS14550 ENOG4108ZG0 Ompa motb domain protein HBN41_RS14555 ENOG4106HNH Acyl-transferase HBN41_RS14570 ENOG4107QMS site-determining protein HBN41_RS14595 ENOG4105CCF Lysine exporter protein (Lyse ygga) HBN41_RS14600 ENOG4105CNU cell division protein FtsK HBN41_RS14605 ENOG4105C3M thioredoxin reductase HBN41_RS14610 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HBN41_RS14620 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HBN41_RS14665 ENOG4108YXA Membrane HBN41_RS14670 ENOG4105EUB pirin domain protein HBN41_RS14680 ENOG4105C4K Nad synthetase HBN41_RS14695 ENOG4105E3J oxidoreductase HBN41_RS14700 ENOG4105C26 Dehydrogenase HBN41_RS14705 ENOG4105DVW rieske (2Fe-2S) HBN41_RS14715 ENOG4105C94 Transporter HBN41_RS14720 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HBN41_RS14725 ENOG4105EJC lysr family transcriptional regulator HBN41_RS14745 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HBN41_RS14765 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HBN41_RS14770 ENOG4105C34 Pseudouridine synthase HBN41_RS14775 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HBN41_RS14780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HBN41_RS14795 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HBN41_RS14825 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HBN41_RS14855 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HBN41_RS14865 ENOG4105DWF phosphomethylpyrimidine kinase HBN41_RS14870 ENOG4109066 lysm domain bon superfamily protein HBN41_RS14880 ENOG4105CHR reductase HBN41_RS14885 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HBN41_RS14895 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HBN41_RS14900 ENOG4108BPE -transporting atpase HBN41_RS14905 ENOG4107RTD sua5 ycio yrdc ywlc family protein HBN41_RS14910 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HBN41_RS14915 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HBN41_RS14920 ENOG4105FE9 pseudouridine synthase HBN41_RS14930 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBN41_RS14935 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HBN41_RS14945 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBN41_RS14950 ENOG4108K4C ec 3.1.3.12 HBN41_RS14955 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HBN41_RS14960 ENOG4106UW1 Major Facilitator superfamily HBN41_RS14980 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HBN41_RS14990 ENOG4105HF0 Membrane HBN41_RS15005 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HBN41_RS15015 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HBN41_RS15065 ENOG4105D1F ATP-binding protein HBN41_RS15075 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HBN41_RS15105 ENOG4105K6H D-cysteine desulfhydrase HBN41_RS15110 ENOG4105CBX hi0933 family HBN41_RS15135 ENOG4105DP0 ferredoxin-NADP reductase HBN41_RS15140 ENOG4105DUM transcriptional regulator, lysR family HBN41_RS15160 ENOG4105C8S subunit m HBN41_RS15165 ENOG4105D65 subunit l HBN41_RS15175 ENOG4107UFS subunit j HBN41_RS15190 ENOG4108IEH NADH dehydrogenase subunit g HBN41_RS15195 ENOG4107QIZ NADH dehydrogenase HBN41_RS15200 ENOG4105GKE subunit e HBN41_RS15220 ENOG4105BZU Histidine kinase HBN41_RS15230 ENOG4105E0F Histidine kinase HBN41_RS15235 ENOG4107EXC regulatoR HBN41_RS15245 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBN41_RS15255 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBN41_RS15265 ENOG4105EB3 Histidine kinase HBN41_RS15335 ENOG4105DZG Dehydrogenase HBN41_RS15355 ENOG4105JAB phenazine biosynthesis protein, phzf family HBN41_RS15375 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HBN41_RS15390 ENOG4105ETT transcriptional Regulator, LysR family HBN41_RS15410 ENOG4105CH2 amidohydrolase HBN41_RS15420 ENOG4106P55 Transcriptional regulator HBN41_RS15435 ENOG4106P55 Transcriptional regulator HBN41_RS15440 ENOG4107EFR Flavocytochrome c HBN41_RS15450 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HBN41_RS15455 ENOG4107RGD Major Facilitator superfamily HBN41_RS15460 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS15465 ENOG4105ETT transcriptional Regulator, LysR family HBN41_RS15500 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HBN41_RS15505 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HBN41_RS15510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBN41_RS15525 ENOG4105VR0 copper resistance HBN41_RS15530 ENOG4105E3B Multicopper oxidase HBN41_RS15540 ENOG4108HCJ Hydrolase HBN41_RS15545 ENOG4105DJV ribulose-phosphate 3-epimerase HBN41_RS15570 ENOG41072GX Peptidase M22 Glycoprotease HBN41_RS15575 ENOG4108Z0R Transferase HBN41_RS15620 ENOG4105CRQ synthase (Component I) HBN41_RS15630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HBN41_RS15635 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HBN41_RS15640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HBN41_RS15710 ENOG4105K56 Transcriptional regulator HBN41_RS15715 ENOG4108ZHJ Organic hydroperoxide resistance protein HBN41_RS15720 ENOG4107QHF type ii secretion system protein e HBN41_RS15750 ENOG4105C2M dna polymerase I HBN41_RS15755 ENOG4108VIA integral membrane protein HBN41_RS15760 ENOG4105II7 pyrroline-5-carboxylate reductase HBN41_RS15765 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HBN41_RS15775 ENOG4105C9X ppx gppa phosphatase HBN41_RS15785 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HBN41_RS15805 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HBN41_RS15845 ENOG4105W39 Membrane HBN41_RS15850 ENOG4105CYM Glutathione S-transferase HBN41_RS15865 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS15870 ENOG4105N42 UPF0307 protein HBN41_RS15875 ENOG41080Z8 PHOSPHOCARRIER protein HBN41_RS15895 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HBN41_RS15900 ENOG4105DJ0 Poly(A) Polymerase HBN41_RS15905 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HBN41_RS15910 ENOG4105DXN mazG family HBN41_RS15920 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HBN41_RS15935 ENOG4105C6T cysteine synthase HBN41_RS15940 ENOG4105BZU Histidine kinase HBN41_RS15945 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HBN41_RS15950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBN41_RS15955 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HBN41_RS15970 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HBN41_RS15975 ENOG4105W8H transhydrogenase (subunit alpha HBN41_RS15980 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HBN41_RS15985 ENOG4106UX7 integral membrane protein HBN41_RS16000 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HBN41_RS16010 ENOG4107RSM transcriptional regulator HBN41_RS16020 ENOG4105CUZ uba thif-type nad fad binding protein HBN41_RS16030 ENOG4107QM5 aconitate hydratase HBN41_RS16035 ENOG4105F8V Hydrolase, tatD family HBN41_RS16050 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HBN41_RS16070 ENOG4105BZU Histidine kinase HBN41_RS16080 ENOG4108ZP8 Acetolactate synthase small subunit HBN41_RS16085 ENOG4105C7K acetolactate synthase HBN41_RS16110 ENOG4105DJY efflux transporter, rnd family, mfp subunit HBN41_RS16115 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HBN41_RS16120 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HBN41_RS16125 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HBN41_RS16135 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HBN41_RS16140 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HBN41_RS16150 ENOG4105VW4 glutaredoxin 3 HBN41_RS16170 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HBN41_RS16175 ENOG4105C2D reductase HBN41_RS16185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HBN41_RS16215 ENOG4105C84 Histidine ammonia-lyase HBN41_RS16230 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS16245 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HBN41_RS16265 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HBN41_RS16285 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HBN41_RS16305 ENOG4105WVQ Fe-S assembly protein IscX HBN41_RS16320 ENOG4105CN1 protease HBN41_RS16335 ENOG4106HB6 Alpha beta hydrolase HBN41_RS16345 ENOG4105C26 Dehydrogenase HBN41_RS16350 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HBN41_RS16355 ENOG4105C6Z Gluconate HBN41_RS16360 ENOG4108UHU Aldolase HBN41_RS16365 ENOG4105C01 Dihydroxy-acid dehydratase HBN41_RS16375 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HBN41_RS16380 ENOG4108DNC Involved in acetate metabolism (By similarity) HBN41_RS16385 ENOG4107GFK fumarate HBN41_RS16405 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HBN41_RS16435 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HBN41_RS16445 ENOG4105DWV Homoserine O-trans-acetylase HBN41_RS16545 ENOG4105CIY formyltetrahydrofolate deformylase HBN41_RS16555 ENOG4107RGH Aldehyde dehydrogenase HBN41_RS16570 ENOG4105CKD glutathione-regulated potassium-efflux system protein HBN41_RS16590 ENOG4105VFU Rna-binding protein HBN41_RS16595 ENOG4105C4R Atp-dependent dna helicase HBN41_RS16610 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HBN41_RS16620 ENOG4105KVH Transcriptional regulator HBN41_RS16635 ENOG4105C5H ABC transporter HBN41_RS16640 ENOG4105N14 lysine exporter protein LysE YggA HBN41_RS16645 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HBN41_RS16655 ENOG4105CK2 sodium dicarboxylate symporter HBN41_RS16710 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HBN41_RS16735 ENOG4105DUM transcriptional regulator, lysR family HBN41_RS16760 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HBN41_RS16775 ENOG4108W5M transcriptional regulator HBN41_RS16790 ENOG4105D29 Helix-turn-helix type 11 domain protein HBN41_RS16795 ENOG4107XGZ Hydrolase HBN41_RS16800 ENOG4105EI2 Pseudouridine synthase HBN41_RS16810 ENOG4105C03 ribonuclease HBN41_RS16815 ENOG4105J5T Amp-dependent synthetase and ligase HBN41_RS16830 ENOG4105CBN LysR family transcriptional regulator HBN41_RS16835 ENOG4105EMU Dehydrogenase HBN41_RS16840 ENOG4105CSA Coproporphyrinogen iii oxidase HBN41_RS16850 ENOG4107QI1 Mate efflux family protein HBN41_RS16860 ENOG4107T8P acyl-Coa dehydrogenase HBN41_RS16905 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HBN41_RS16910 ENOG4105C5X domain protein HBN41_RS16925 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HBN41_RS16935 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HBN41_RS16940 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HBN41_RS16945 ENOG4108JU5 Magnesium and cobalt efflux protein HBN41_RS16950 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HBN41_RS16955 ENOG4108Z7R Chaperone CsaA HBN41_RS16965 ENOG4108VAU general secretion pathway protein G HBN41_RS16970 ENOG4105D7Q type ii secretion system HBN41_RS16975 ENOG4105C25 Primosomal protein n' HBN41_RS16980 ENOG4105CKD glutathione-regulated potassium-efflux system protein HBN41_RS16985 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HBN41_RS16995 ENOG4105DVC DnaJ domain protein HBN41_RS17000 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HBN41_RS17005 ENOG4107QUT magnesium and cobalt transport protein CorA HBN41_RS17030 ENOG4107QYX exodeoxyribonuclease v alpha HBN41_RS17035 ENOG4107QKA exodeoxyribonuclease V beta HBN41_RS17040 ENOG4105DSY exodeoxyribonuclease V, gamma HBN41_RS17050 ENOG4105CSR polyphosphate kinase 2 HBN41_RS17060 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HBN41_RS17075 ENOG41061H0 Monooxygenase HBN41_RS17080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HBN41_RS17095 ENOG4105D65 subunit l HBN41_RS17100 ENOG4108ZE9 Monovalent cation H antiporter subunit C HBN41_RS17105 ENOG4107R4Z monovalent cation h antiporter subunit d HBN41_RS17110 ENOG4105SC1 monovalent cation H antiporter subunit E HBN41_RS17115 ENOG4105W4C monovalent cation H antiporter subunit F HBN41_RS17120 ENOG4105KJM monovalent cation h antiporter subunit g HBN41_RS17135 ENOG4105CHV Transcription elongation factor NusA HBN41_RS17160 ENOG4107EJC Preprotein translocase subunit SecG HBN41_RS17170 ENOG4107QHF type ii secretion system protein e HBN41_RS17185 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HBN41_RS17195 ENOG4105C2N RNA methyltransferase TrmH family group 3 HBN41_RS17210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HBN41_RS17220 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HBN41_RS17250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBN41_RS17255 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HBN41_RS17320 ENOG4107ZXU DSBA oxidoreductase HBN41_RS17335 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HBN41_RS17350 ENOG4105D3Y Na H antiporter HBN41_RS17355 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HBN41_RS17405 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HBN41_RS17410 ENOG4105PM1 preprotein translocase subunit SecE HBN41_RS17450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HBN41_RS17455 ENOG4105TV9 FHA Domain-Containing protein HBN41_RS17460 ENOG4105GVR general secretion pathway protein D HBN41_RS17475 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HBN41_RS17500 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HBN41_RS17505 ENOG4108NEV two component transcriptional regulator, LytTR family HBN41_RS17510 ENOG4108HRK Histidine kinase HBN41_RS17525 ENOG4108UTW Plays a role in the regulation of phosphate uptake HBN41_RS17530 ENOG4105DFG type I secretion outer membrane protein HBN41_RS17535 ENOG4108RNG Permease of the drug metabolite transporter HBN41_RS17560 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HBN41_RS17570 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HBN41_RS17575 ENOG4105CNI cell division protein FtsW HBN41_RS17590 ENOG4105CE1 Ferrous iron transport protein b HBN41_RS17600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBN41_RS17605 ENOG4105T95 Thiol disulfide interChange protein HBN41_RS17610 ENOG4105D6E homoserine dehydrogenase HBN41_RS17620 ENOG41061WM D-Alanyl-D-Alanine HBN41_RS17630 ENOG4107TUY Histidine kinase HBN41_RS17635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HBN41_RS17640 ENOG4105CN1 protease HBN41_RS17645 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HBN41_RS17650 ENOG4108K5H permease YjgP YjgQ family protein HBN41_RS17690 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HBN41_RS17700 ENOG4105BZU Histidine kinase HBN41_RS17715 ENOG4105C0P Mg chelatase subunit ChlI HBN41_RS17725 ENOG4108R0M Aminoglycoside HBN41_RS17780 ENOG4108HWY Beta-lactamase HBN41_RS17790 ENOG4105F6A helicase HBN41_RS17835 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HBN41_RS17875 ENOG4105CHH sulfate transporter HBN41_RS17905 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBN41_RS17930 ENOG4108HWY Beta-lactamase HBN41_RS17940 ENOG4105F6A helicase HBN41_RS17955 ENOG4105CHH sulfate transporter HBN41_RS18010 ENOG4105C0P Mg chelatase subunit ChlI HBN41_RS18025 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBN41_RS18035 ENOG4105EPF Outer membrane porin HBN41_RS18040 ENOG4105F0N pyrophosphate phospho-hydrolase HBN41_RS18055 ENOG4105CEY Amp-dependent synthetase and ligase HBN41_RS18060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBN41_RS18065 ENOG41079KZ Major Facilitator Superfamily HBN41_RS18070 ENOG4105EN6 Membrane HBN41_RS18080 ENOG4105EE5 Membrane protein terC HBN41_RS18085 ENOG4108URH decarboxylase HBN41_RS18100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HBN41_RS18115 ENOG4105CCT upf0313 protein HBN41_RS18135 ENOG4105CS1 NAD(P)H quinone oxidoreductase HBN41_RS18145 ENOG4105C6T cysteine synthase HBN41_RS18180 ENOG4105Y7M Transcriptional regulator, TetR family HBN41_RS18215 ENOG4105C79 DNA protecting protein DprA HBN41_RS18230 ENOG4108IND Tetr family transcriptional regulator HBN41_RS18235 ENOG4107RTG Major Facilitator superfamily HBN41_RS18245 ENOG4108V06 Glutathione peroxidase HBN41_RS18310 ENOG4105FDK ABC transporter HBN41_RS18315 ENOG4105FAV ABC, transporter HBN41_RS18320 ENOG410829K Lysine exporter protein (Lyse ygga) HBN41_RS18325 ENOG4105EZR dyp-type peroxidase family protein HBN41_RS18335 ENOG4107R1I NAD-dependent malic enzyme HBN41_RS18360 ENOG4105EUB pirin domain protein HBN41_RS18380 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HBN41_RS18385 ENOG4106MP8 UPF0754 membrane protein HBN41_RS18390 ENOG4108VBZ doxx family HBN41_RS18395 ENOG4105DQR SNARE associated Golgi HBN41_RS18410 ENOG4107QJE Chromosome Partitioning Protein HBN41_RS18420 ENOG4107PSF BolA-like protein HBN41_RS18440 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HBN41_RS18465 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS18490 ENOG4105CSH Transporter HBN41_RS18495 ENOG4105E39 Enoyl-CoA hydratase HBN41_RS18500 ENOG4105E39 Enoyl-CoA hydratase HBN41_RS18505 ENOG4105C1G acyl-Coa dehydrogenase HBN41_RS18515 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBN41_RS18520 ENOG4105C26 Dehydrogenase HBN41_RS18530 ENOG4105C85 amino acid HBN41_RS18535 ENOG4105C85 amino acid HBN41_RS18540 ENOG4105M4H endoribonuclease L-psp HBN41_RS18555 ENOG4105EW9 transcriptional regulator AsnC family HBN41_RS18580 ENOG4105D3G Pseudouridine synthase HBN41_RS18595 ENOG4108IG5 Transcriptional regulator HBN41_RS18640 ENOG4108I0Z Aconitate hydratase HBN41_RS18645 ENOG4105BZN citrate synthase HBN41_RS18650 ENOG4105CR4 methylisocitrate lyase HBN41_RS18655 ENOG4105DRR Transcriptional regulator, GntR family HBN41_RS18665 ENOG4105CGF Aromatic amino acid aminotransferase HBN41_RS18670 ENOG4105CXG d-lactate dehydrogenase HBN41_RS18680 ENOG41073TP transcriptional regulator HBN41_RS18685 ENOG4105DAA L-lactate HBN41_RS18690 ENOG4107QKV phosphomannomutase HBN41_RS18695 ENOG4105CMR udp-glucose 4-epimerase HBN41_RS18705 ENOG4105C6Y Udp-glucose 6-dehydrogenase HBN41_RS18710 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HBN41_RS18725 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HBN41_RS18740 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HBN41_RS18790 ENOG4105F0R Cytidylyltransferase HBN41_RS18805 ENOG4105D2T synthase HBN41_RS18810 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase HBN41_RS18815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HBN41_RS18825 ENOG4107QQG Dehydrogenase HBN41_RS18830 ENOG4105DAY polysaccharide export protein HBN41_RS18840 ENOG4105D75 Capsular exopolysaccharide family HBN41_RS18845 ENOG4108V1T peptidylprolyl cis-trans isomerase HBN41_RS18850 ENOG4108V1T peptidylprolyl cis-trans isomerase HBN41_RS18855 ENOG4105CJR Integral membrane protein (MviN HBN41_RS18860 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HBN41_RS18865 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HBN41_RS18875 ENOG4105HSS phospholipase C HBN41_RS18900 ENOG41062JF Transcriptional regulator HBN41_RS18905 ENOG4108Z33 Thiol disulfide Interchange Protein HBN41_RS18915 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HBN41_RS18920 ENOG4105UBK short-chain dehydrogenase reductase HBN41_RS18935 ENOG4107QZM n-acetylglutamate synthase HBN41_RS18940 ENOG4105GVF (ABC) transporter HBN41_RS18945 ENOG4105GVF (ABC) transporter HBN41_RS18950 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HBN41_RS18955 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HBN41_RS18960 ENOG4108VM9 ABC, transporter HBN41_RS18965 ENOG4108R86 Transcriptional regulator HBN41_RS18970 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HBN41_RS18980 ENOG4105DTN riboflavin biosynthesis protein ribF HBN41_RS18985 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HBN41_RS18995 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HBN41_RS19035 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HBN41_RS19090 ENOG4105CVE Lytic murein transglycosylase HBN41_RS19095 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HBN41_RS19100 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HBN41_RS19110 ENOG4105DFU Cell wall formation (By similarity) HBN41_RS19120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HBN41_RS19125 ENOG4105DU1 integral membrane protein, terc HBN41_RS19135 ENOG4106032 Glutathionylspermidine synthase HBN41_RS19145 ENOG4107QUY Guanine deaminase HBN41_RS19150 ENOG4108UGV hypoxanthine phosphoribosyltransferase HBN41_RS19160 ENOG4105T95 Thiol disulfide interChange protein HBN41_RS19165 ENOG4105PGM cation diffusion facilitator family transporter HBN41_RS19180 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HBN41_RS19230 ENOG4105UGU tonB-dependent Receptor