locus-tag	class	description
NE424_RS00060	COG3111	PFAM Bacterial OB fold (BOF) protein
NE424_RS00085	COG3243	poly(R)-hydroxyalkanoic acid synthase
NE424_RS00090	COG0786	glutamate:sodium symporter activity
NE424_RS00100	COG2186	Transcriptional regulator
NE424_RS00150	COG0477	Major facilitator Superfamily
NE424_RS00175	COG2995	paraquat-inducible protein a
NE424_RS00180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NE424_RS00180	COG3008	intermembrane lipid transfer
NE424_RS00190	COG2351	hydroxyisourate hydrolase activity
NE424_RS00230	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NE424_RS00240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NE424_RS00245	COG0642	Histidine kinase
NE424_RS00250	COG0745	RESPONSE REGULATOR receiver
NE424_RS00270	COG1794	racemase activity, acting on amino acids and derivatives
NE424_RS00300	COG1301	dicarboxylic acid transport
NE424_RS00310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE424_RS00315	COG2011	ABC-type metal ion transport system permease component
NE424_RS00320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NE424_RS00325	COG1464	Belongs to the NlpA lipoprotein family
NE424_RS00330	COG0151	Belongs to the GarS family
NE424_RS00335	COG0138	bifunctional purine biosynthesis protein purh
NE424_RS00340	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NE424_RS00370	COG2308	Evidence 4 Homologs of previously reported genes of
NE424_RS00380	COG1305	Transglutaminase-like
NE424_RS00390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NE424_RS00395	COG0305	Participates in initiation and elongation during chromosome replication
NE424_RS00420	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NE424_RS00430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NE424_RS00435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NE424_RS00460	COG0726	polysaccharide deacetylase
NE424_RS00460	COG1649	PFAM Uncharacterised BCR, COG1649
NE424_RS00465	COG1215	transferase activity, transferring glycosyl groups
NE424_RS00470	COG3658	cytochrome
NE424_RS00480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS00495	COG0583	DNA-binding transcription factor activity
NE424_RS00525	COG1960	acyl-CoA dehydrogenase activity
NE424_RS00530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE424_RS00535	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS00540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NE424_RS00560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NE424_RS00565	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NE424_RS00575	COG2205	protein histidine kinase activity
NE424_RS00580	COG0745	RESPONSE REGULATOR receiver
NE424_RS00585	COG0174	glutamine synthetase
NE424_RS00605	COG0729	surface antigen
NE424_RS00630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NE424_RS00635	COG2814	Major facilitator Superfamily
NE424_RS00715	COG3409	Peptidoglycan-binding domain 1 protein
NE424_RS00715	COG3267	Type II secretory pathway component ExeA
NE424_RS00790	COG4373	Mu-like prophage FluMu protein gp28
NE424_RS00805	COG4383	Mu-like prophage protein gp29
NE424_RS00810	COG2369	cell adhesion
NE424_RS00930	COG0583	DNA-binding transcription factor activity
NE424_RS00945	COG1187	pseudouridine synthase activity
NE424_RS00965	COG0802	atpase or kinase
NE424_RS00970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NE424_RS00980	COG1923	regulation of RNA biosynthetic process
NE424_RS00985	COG0697	spore germination
NE424_RS01010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NE424_RS01015	COG0519	Catalyzes the synthesis of GMP from XMP
NE424_RS01015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NE424_RS01020	COG4302	ethanolamine ammonia-lyase activity
NE424_RS01025	COG4303	Ethanolamine ammonia lyase large subunit
NE424_RS01030	COG0531	amino acid
NE424_RS01050	COG1454	alcohol dehydrogenase
NE424_RS01055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE424_RS01065	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NE424_RS01085	COG0308	aminopeptidase N
NE424_RS01105	COG1605	Chorismate mutase
NE424_RS01140	COG2885	chlorophyll binding
NE424_RS01140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE424_RS01160	COG2885	chlorophyll binding
NE424_RS01160	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE424_RS01170	COG1538	Outer membrane efflux protein
NE424_RS01200	COG1234	tRNA 3'-trailer cleavage
NE424_RS01205	COG2271	Major facilitator Superfamily
NE424_RS01215	COG3971	2-oxopent-4-enoate hydratase activity
NE424_RS01220	COG4569	acetaldehyde dehydrogenase (acetylating) activity
NE424_RS01240	COG0583	DNA-binding transcription factor activity
NE424_RS01245	COG4638	Rieske (2fe-2S)
NE424_RS01250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NE424_RS01260	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS01265	COG3384	dioxygenase
NE424_RS01270	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE424_RS01275	COG2814	Major facilitator Superfamily
NE424_RS01280	COG2814	Major facilitator Superfamily
NE424_RS01285	COG0583	DNA-binding transcription factor activity
NE424_RS01325	COG0668	transmembrane transport
NE424_RS01355	COG4773	Receptor
NE424_RS01375	COG0488	(ABC) transporter
NE424_RS01380	COG0589	response to stress
NE424_RS01405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NE424_RS01415	COG3135	benzoate transporter
NE424_RS01420	COG1522	sequence-specific DNA binding
NE424_RS01430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NE424_RS01435	COG0583	DNA-binding transcription factor activity
NE424_RS01445	COG0183	Belongs to the thiolase family
NE424_RS01455	COG2030	dehydratase
NE424_RS01460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NE424_RS01485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NE424_RS01495	COG0824	Thioesterase
NE424_RS01500	COG1454	alcohol dehydrogenase
NE424_RS01510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NE424_RS01530	COG0069	glutamate synthase activity
NE424_RS01550	COG2814	Major facilitator Superfamily
NE424_RS01565	COG0511	ligase activity, forming carbon-carbon bonds
NE424_RS01585	COG1116	anion transmembrane transporter activity
NE424_RS01585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE424_RS01590	COG0745	RESPONSE REGULATOR receiver
NE424_RS01600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE424_RS01600	COG2146	nitrite reductase [NAD(P)H] activity
NE424_RS01605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE424_RS01610	COG0243	molybdopterin cofactor binding
NE424_RS01620	COG0243	molybdopterin cofactor binding
NE424_RS01625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NE424_RS01640	COG0315	cyclic pyranopterin monophosphate synthase activity
NE424_RS01640	COG0521	Mo-molybdopterin cofactor biosynthetic process
NE424_RS01655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE424_RS01660	COG0697	spore germination
NE424_RS01680	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NE424_RS01685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NE424_RS01740	COG2204	response regulator
NE424_RS01745	COG3852	Histidine kinase
NE424_RS01770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NE424_RS01775	COG0575	Belongs to the CDS family
NE424_RS01810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NE424_RS01825	COG2137	regulation of response to DNA damage stimulus
NE424_RS01835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NE424_RS01840	COG1011	Hydrolase
NE424_RS01865	COG1522	sequence-specific DNA binding
NE424_RS01875	COG1113	amino acid transport
NE424_RS01895	COG0659	secondary active sulfate transmembrane transporter activity
NE424_RS01915	COG5001	Diguanylate cyclase
NE424_RS01915	COG3300	MHYT domain
NE424_RS01930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NE424_RS01930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NE424_RS01930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NE424_RS01935	COG1105	Belongs to the carbohydrate kinase PfkB family
NE424_RS01940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NE424_RS01940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NE424_RS01970	COG0024	Methionine aminopeptidase
NE424_RS01975	COG0583	DNA-binding transcription factor activity
NE424_RS01985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NE424_RS01990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NE424_RS01995	COG0516	GMP reductase activity
NE424_RS01995	COG0517	IMP dehydrogenase activity
NE424_RS02020	COG0552	protein localization to endoplasmic reticulum
NE424_RS02030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NE424_RS02040	COG4890	Cyd operon protein YbgT
NE424_RS02045	COG1294	oxidase, subunit
NE424_RS02060	COG1585	Membrane protein implicated in regulation of membrane protease activity
NE424_RS02070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NE424_RS02075	COG4774	siderophore transport
NE424_RS02090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NE424_RS02095	COG0569	domain protein
NE424_RS02100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NE424_RS02130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NE424_RS02135	COG0542	response to heat
NE424_RS02160	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE424_RS02160	COG1902	pentaerythritol trinitrate reductase activity
NE424_RS02205	COG2323	membrane
NE424_RS02210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NE424_RS02220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE424_RS02225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE424_RS02230	COG0183	Belongs to the thiolase family
NE424_RS02235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NE424_RS02240	COG0596	Alpha beta hydrolase
NE424_RS02245	COG2271	Major facilitator Superfamily
NE424_RS02250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NE424_RS02255	COG3485	protocatechuate 3,4-dioxygenase
NE424_RS02260	COG3485	protocatechuate 3,4-dioxygenase
NE424_RS02265	COG0710	3-dehydroquinate dehydratase activity
NE424_RS02270	COG3420	alginic acid biosynthetic process
NE424_RS02275	COG3659	wide pore channel activity
NE424_RS02280	COG4993	Dehydrogenase
NE424_RS02290	COG2391	methyltransferase activity
NE424_RS02305	COG1414	Transcriptional regulator
NE424_RS02310	COG0583	DNA-binding transcription factor activity
NE424_RS02315	COG1960	acyl-CoA dehydrogenase activity
NE424_RS02340	COG2814	Major facilitator Superfamily
NE424_RS02350	COG0154	amidase activity
NE424_RS02370	COG4638	Rieske (2fe-2S)
NE424_RS02380	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS02390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS02400	COG3733	amine oxidase
NE424_RS02410	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS02415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE424_RS02420	COG0183	Belongs to the thiolase family
NE424_RS02425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE424_RS02430	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE424_RS02440	COG4829	muconolactone delta-isomerase
NE424_RS02445	COG4948	Mandelate Racemase Muconate Lactonizing
NE424_RS02450	COG0583	DNA-binding transcription factor activity
NE424_RS02460	COG2186	Transcriptional regulator
NE424_RS02480	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS02485	COG3231	kanamycin kinase activity
NE424_RS02500	COG1960	acyl-CoA dehydrogenase activity
NE424_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS02510	COG3829	transcription factor binding
NE424_RS02520	COG3162	membrane
NE424_RS02535	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS02570	COG1846	Transcriptional regulator
NE424_RS02585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NE424_RS02615	COG1309	transcriptional regulator
NE424_RS02625	COG1335	isochorismatase
NE424_RS02630	COG0583	DNA-binding transcription factor activity
NE424_RS02640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE424_RS02640	COG0475	glutathione-regulated potassium exporter activity
NE424_RS02650	COG1473	amidohydrolase
NE424_RS02710	COG2188	Transcriptional regulator
NE424_RS02725	COG0583	DNA-binding transcription factor activity
NE424_RS02750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS02765	COG2271	Major facilitator Superfamily
NE424_RS02775	COG1566	PFAM secretion protein HlyD family protein
NE424_RS02790	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS02795	COG0129	dihydroxy-acid dehydratase activity
NE424_RS02805	COG0583	DNA-binding transcription factor activity
NE424_RS02810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NE424_RS02820	COG2084	Dehydrogenase
NE424_RS02825	COG2207	Transcriptional regulator
NE424_RS02840	COG1064	alcohol dehydrogenase
NE424_RS02850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NE424_RS02855	COG1120	ATPase activity
NE424_RS02875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NE424_RS02925	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NE424_RS02965	COG1073	alpha beta
NE424_RS02985	COG2205	protein histidine kinase activity
NE424_RS02990	COG0745	RESPONSE REGULATOR receiver
NE424_RS02995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS03000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE424_RS03015	COG0402	S-adenosylhomocysteine deaminase activity
NE424_RS03025	COG2814	Major facilitator Superfamily
NE424_RS03035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NE424_RS03050	COG1024	Enoyl-CoA hydratase
NE424_RS03120	COG2826	transposase and inactivated derivatives, IS30 family
NE424_RS03200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS03205	COG4771	TonB-dependent receptor
NE424_RS03235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS03240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE424_RS03245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE424_RS03250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE424_RS03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NE424_RS03280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS03300	COG1132	(ABC) transporter
NE424_RS03305	COG1132	(ABC) transporter
NE424_RS03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NE424_RS03330	COG0601	transmembrane transport
NE424_RS03335	COG0747	negative chemotaxis
NE424_RS03360	COG3539	Fimbrial protein
NE424_RS03390	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NE424_RS03400	COG0753	catalase activity
NE424_RS03415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NE424_RS03475	COG3433	isochorismatase activity
NE424_RS03475	COG1535	isochorismatase
NE424_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS03485	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NE424_RS03490	COG4149	molybdate abc transporter
NE424_RS03495	COG0725	ABC transporter, periplasmic molybdate-binding protein
NE424_RS03505	COG4638	Rieske (2fe-2S)
NE424_RS03510	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NE424_RS03515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS03515	COG0543	2 iron, 2 sulfur cluster binding
NE424_RS03530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS03555	COG2207	Transcriptional regulator
NE424_RS03560	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS03565	COG2610	gluconate transmembrane transporter activity
NE424_RS03575	COG1309	transcriptional regulator
NE424_RS03595	COG0583	DNA-binding transcription factor activity
NE424_RS03610	COG2031	fatty acid transporter
NE424_RS03615	COG0183	Belongs to the thiolase family
NE424_RS03620	COG0583	DNA-binding transcription factor activity
NE424_RS03625	COG0583	DNA-binding transcription factor activity
NE424_RS03640	COG1027	Aspartate ammonia-lyase
NE424_RS03650	COG0477	Major facilitator Superfamily
NE424_RS03670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE424_RS03675	COG4521	taurine ABC transporter
NE424_RS03690	COG2188	Transcriptional regulator
NE424_RS03700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NE424_RS03705	COG1733	regulation of RNA biosynthetic process
NE424_RS03710	COG3708	Transcriptional regulator
NE424_RS03710	COG2207	Transcriptional regulator
NE424_RS03725	COG0730	response to heat
NE424_RS03740	COG3453	Protein conserved in bacteria
NE424_RS03740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE424_RS03750	COG3781	membrane
NE424_RS03755	COG1063	alcohol dehydrogenase
NE424_RS03765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE424_RS03770	COG0508	dehydrogenase complex catalyzes the overall conversion of
NE424_RS03775	COG0022	dehydrogenase e1 component
NE424_RS03780	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NE424_RS03785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NE424_RS03800	COG3706	GGDEF domain
NE424_RS03815	COG0133	tryptophan synthase activity
NE424_RS03825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NE424_RS03860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NE424_RS03885	COG2226	methyltransferase
NE424_RS03940	COG0842	Transport permease protein
NE424_RS03945	COG0842	Transport permease protein
NE424_RS03950	COG1131	(ABC) transporter
NE424_RS03965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NE424_RS03970	COG4773	Receptor
NE424_RS03990	COG0730	response to heat
NE424_RS03995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NE424_RS04010	COG0406	alpha-ribazole phosphatase activity
NE424_RS04015	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NE424_RS04030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NE424_RS04060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NE424_RS04070	COG4264	IucA IucC family
NE424_RS04075	COG4264	IucA IucC family
NE424_RS04080	COG2814	Major facilitator Superfamily
NE424_RS04095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NE424_RS04110	COG1960	acyl-CoA dehydrogenase activity
NE424_RS04115	COG1960	acyl-CoA dehydrogenase activity
NE424_RS04120	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE424_RS04125	COG2207	Transcriptional regulator
NE424_RS04130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NE424_RS04135	COG0776	regulation of translation
NE424_RS04160	COG0822	iron-sulfur transferase activity
NE424_RS04165	COG0316	Belongs to the HesB IscA family
NE424_RS04195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NE424_RS04215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NE424_RS04220	COG0702	epimerase
NE424_RS04255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NE424_RS04265	COG0339	signal peptide processing
NE424_RS04315	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NE424_RS04320	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NE424_RS04350	COG0776	regulation of translation
NE424_RS04415	COG0084	hydrolase, TatD family'
NE424_RS04435	COG1663	tetraacyldisaccharide 4'-kinase activity
NE424_RS04440	COG1132	(ABC) transporter
NE424_RS04450	COG0811	peptide transport
NE424_RS04455	COG1475	DNA binding
NE424_RS04460	COG1192	Involved in chromosome partitioning
NE424_RS04470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NE424_RS04485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NE424_RS04490	COG0191	fructose-bisphosphate aldolase activity
NE424_RS04510	COG0424	maF-like protein
NE424_RS04515	COG2850	peptidyl-arginine hydroxylation
NE424_RS04525	COG0640	Transcriptional regulator
NE424_RS04535	COG3619	membrane
NE424_RS04540	COG3122	Protein conserved in bacteria
NE424_RS04545	COG1132	(ABC) transporter
NE424_RS04565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NE424_RS04570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NE424_RS04580	COG0506	proline dehydrogenase activity
NE424_RS04580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NE424_RS04580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NE424_RS04585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NE424_RS04600	COG3698	Phosphodiester glycosidase
NE424_RS04610	COG2353	YceI-like domain
NE424_RS04620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NE424_RS04665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NE424_RS04665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NE424_RS04690	COG3539	Fimbrial protein
NE424_RS04695	COG3121	Chaperone
NE424_RS04720	COG0697	spore germination
NE424_RS04730	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NE424_RS04740	COG0583	DNA-binding transcription factor activity
NE424_RS04760	COG1309	transcriptional regulator
NE424_RS04775	COG1522	sequence-specific DNA binding
NE424_RS04785	COG1126	abc transporter atp-binding protein
NE424_RS04790	COG0765	amino acid transport
NE424_RS04795	COG0765	amino acid transport
NE424_RS04825	COG1464	Belongs to the NlpA lipoprotein family
NE424_RS04835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NE424_RS04840	COG2011	ABC-type metal ion transport system permease component
NE424_RS04845	COG0012	GTP binding
NE424_RS04870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NE424_RS04910	COG0386	Belongs to the glutathione peroxidase family
NE424_RS04920	COG0436	Aminotransferase
NE424_RS04925	COG1301	dicarboxylic acid transport
NE424_RS04960	COG3634	alkyl hydroperoxide reductase activity
NE424_RS04975	COG0583	DNA-binding transcription factor activity
NE424_RS04980	COG0798	PFAM Bile acid sodium symporter
NE424_RS04985	COG0640	Transcriptional regulator
NE424_RS05010	COG0583	DNA-binding transcription factor activity
NE424_RS05020	COG1953	Uracil, thiamine, allantoin
NE424_RS05030	COG2175	clavaminate synthase activity
NE424_RS05035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE424_RS05040	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NE424_RS05045	COG4521	taurine ABC transporter
NE424_RS05055	COG0477	Major facilitator Superfamily
NE424_RS05075	COG1271	oxidase subunit
NE424_RS05080	COG1294	oxidase, subunit
NE424_RS05090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE424_RS05110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NE424_RS05130	COG3052	prosthetic group binding
NE424_RS05135	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NE424_RS05145	COG0300	oxidoreductase activity
NE424_RS05165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE424_RS05170	COG1346	cytolysis
NE424_RS05180	COG0583	DNA-binding transcription factor activity
NE424_RS05185	COG0625	glutathione transferase activity
NE424_RS05190	COG0625	glutathione transferase activity
NE424_RS05195	COG0583	DNA-binding transcription factor activity
NE424_RS05210	COG1045	serine acetyltransferase
NE424_RS05215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NE424_RS05220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NE424_RS05230	COG1280	lysine exporter protein (LysE YggA)
NE424_RS05245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE424_RS05250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE424_RS05255	COG1126	abc transporter atp-binding protein
NE424_RS05260	COG0765	amino acid transport
NE424_RS05265	COG0765	amino acid transport
NE424_RS05285	COG0784	Response regulator, receiver
NE424_RS05285	COG2205	protein histidine kinase activity
NE424_RS05305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NE424_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS05375	COG0583	DNA-binding transcription factor activity
NE424_RS05395	COG0318	PFAM AMP-dependent synthetase and ligase
NE424_RS05400	COG1309	transcriptional regulator
NE424_RS05405	COG1960	acyl-CoA dehydrogenase activity
NE424_RS05410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NE424_RS05415	COG1024	Enoyl-CoA hydratase
NE424_RS05420	COG4770	biotin carboxylase activity
NE424_RS05430	COG0583	DNA-binding transcription factor activity
NE424_RS05445	COG1960	acyl-CoA dehydrogenase activity
NE424_RS05455	COG2814	Major facilitator Superfamily
NE424_RS05465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE424_RS05470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE424_RS05475	COG2814	Major facilitator Superfamily
NE424_RS05480	COG1960	acyl-CoA dehydrogenase activity
NE424_RS05485	COG1024	Enoyl-CoA hydratase
NE424_RS05490	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS05495	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE424_RS05500	COG0183	Belongs to the thiolase family
NE424_RS05510	COG2814	Major facilitator Superfamily
NE424_RS05520	COG1024	Enoyl-CoA hydratase
NE424_RS05535	COG1960	acyl-CoA dehydrogenase activity
NE424_RS05540	COG2814	Major facilitator Superfamily
NE424_RS05545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NE424_RS05550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NE424_RS05565	COG3842	ATPase activity
NE424_RS05570	COG1840	ABC-type Fe3 transport system, periplasmic component
NE424_RS05580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS05585	COG1414	Transcriptional regulator
NE424_RS05595	COG0583	DNA-binding transcription factor activity
NE424_RS05600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NE424_RS05605	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS05615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NE424_RS05625	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS05630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS05635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS05640	COG2267	carboxylic ester hydrolase activity
NE424_RS05660	COG3038	cytochrome b561
NE424_RS05665	COG0753	catalase activity
NE424_RS05685	COG2050	protein possibly involved in aromatic compounds catabolism
NE424_RS05695	COG3327	negative regulation of DNA-templated transcription, initiation
NE424_RS05700	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NE424_RS05705	COG0183	Belongs to the thiolase family
NE424_RS05710	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE424_RS05715	COG1024	Enoyl-CoA hydratase
NE424_RS05720	COG1024	Enoyl-CoA hydratase
NE424_RS05725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS05730	COG2151	metal-sulfur cluster biosynthetic enzyme
NE424_RS05735	COG3396	Phenylacetate-CoA oxygenase
NE424_RS05740	COG3460	Phenylacetate-CoA oxygenase
NE424_RS05745	COG3396	Phenylacetate-CoA oxygenase
NE424_RS05750	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS05750	COG2030	dehydratase
NE424_RS05755	COG1760	l-serine dehydratase
NE424_RS05760	COG0531	amino acid
NE424_RS05765	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS05790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NE424_RS05810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE424_RS05820	COG0789	Transcriptional regulator
NE424_RS05830	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NE424_RS05845	COG2807	transmembrane transport
NE424_RS05850	COG0590	tRNA wobble adenosine to inosine editing
NE424_RS06010	COG1116	anion transmembrane transporter activity
NE424_RS06015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NE424_RS06025	COG0864	Transcriptional regulator
NE424_RS06035	COG1733	regulation of RNA biosynthetic process
NE424_RS06040	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE424_RS06045	COG0439	Biotin carboxylase
NE424_RS06060	COG1063	alcohol dehydrogenase
NE424_RS06070	COG1309	transcriptional regulator
NE424_RS06080	COG3210	domain, Protein
NE424_RS06085	COG2831	hemolysin activation secretion protein
NE424_RS06090	COG0038	chloride channel
NE424_RS06095	COG4770	biotin carboxylase activity
NE424_RS06115	COG1914	H( )-stimulated, divalent metal cation uptake system
NE424_RS06120	COG0583	DNA-binding transcription factor activity
NE424_RS06140	COG1250	3-hydroxyacyl-CoA dehydrogenase
NE424_RS06160	COG2814	Major facilitator Superfamily
NE424_RS06175	COG1560	Kdo2-lipid A biosynthetic process
NE424_RS06185	COG5006	permease, DMT superfamily
NE424_RS06190	COG1522	sequence-specific DNA binding
NE424_RS06205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NE424_RS06215	COG4122	O-methyltransferase activity
NE424_RS06245	COG1538	Outer membrane efflux protein
NE424_RS06255	COG1137	ATPase activity
NE424_RS06260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NE424_RS06270	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NE424_RS06275	COG0517	IMP dehydrogenase activity
NE424_RS06275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NE424_RS06340	COG2814	Major facilitator Superfamily
NE424_RS06375	COG1278	Cold shock
NE424_RS06380	COG1280	lysine exporter protein (LysE YggA)
NE424_RS06410	COG1570	exodeoxyribonuclease VII activity
NE424_RS06495	COG2871	sodium ion transport
NE424_RS06505	COG0583	DNA-binding transcription factor activity
NE424_RS06515	COG4638	Rieske (2fe-2S)
NE424_RS06525	COG0543	2 iron, 2 sulfur cluster binding
NE424_RS06525	COG0633	Ferredoxin
NE424_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS06535	COG3135	benzoate transporter
NE424_RS06540	COG2814	Major facilitator Superfamily
NE424_RS06555	COG1643	Atp-dependent helicase
NE424_RS06560	COG0450	alkyl hydroperoxide reductase
NE424_RS06570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NE424_RS06580	COG3634	alkyl hydroperoxide reductase activity
NE424_RS06600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NE424_RS06605	COG0625	glutathione transferase activity
NE424_RS06615	COG2885	chlorophyll binding
NE424_RS06650	COG0542	response to heat
NE424_RS06665	COG1765	OsmC-like protein
NE424_RS06680	COG0667	Aldo Keto reductase
NE424_RS06695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NE424_RS06705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NE424_RS06715	COG0582	viral genome integration into host DNA
NE424_RS06720	COG2194	sulfuric ester hydrolase activity
NE424_RS06835	COG3566	protein conserved in bacteria
NE424_RS06850	COG3567	Phage-associated protein, HI1409 family
NE424_RS06855	COG5410	chromosome segregation
NE424_RS06955	COG3620	sequence-specific DNA binding
NE424_RS07005	COG0527	aspartate kinase activity
NE424_RS07015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NE424_RS07025	COG3038	cytochrome b561
NE424_RS07030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NE424_RS07035	COG2252	PERMEase
NE424_RS07045	COG2072	flavoprotein involved in K transport
NE424_RS07060	COG1741	Belongs to the pirin family
NE424_RS07065	COG1309	transcriptional regulator
NE424_RS07075	COG0300	oxidoreductase activity
NE424_RS07080	COG2072	flavoprotein involved in K transport
NE424_RS07085	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NE424_RS07090	COG0583	DNA-binding transcription factor activity
NE424_RS07105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NE424_RS07110	COG2207	Transcriptional regulator
NE424_RS07150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE424_RS07165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS07180	COG2814	Major facilitator Superfamily
NE424_RS07185	COG1024	Enoyl-CoA hydratase
NE424_RS07190	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS07200	COG1960	acyl-CoA dehydrogenase activity
NE424_RS07225	COG2186	Transcriptional regulator
NE424_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS07240	COG4948	Mandelate Racemase Muconate Lactonizing
NE424_RS07245	COG2271	Major facilitator Superfamily
NE424_RS07250	COG2721	sulfolactate sulfo-lyase activity
NE424_RS07255	COG0697	spore germination
NE424_RS07270	COG1113	amino acid transport
NE424_RS07290	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS07310	COG0531	amino acid
NE424_RS07320	COG1113	amino acid transport
NE424_RS07355	COG0183	Belongs to the thiolase family
NE424_RS07360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NE424_RS07365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NE424_RS07380	COG3485	protocatechuate 3,4-dioxygenase
NE424_RS07385	COG1454	alcohol dehydrogenase
NE424_RS07390	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS07410	COG2814	Major facilitator Superfamily
NE424_RS07415	COG0583	DNA-binding transcription factor activity
NE424_RS07425	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE424_RS07460	COG2059	Chromate
NE424_RS07470	COG1230	cation diffusion facilitator family transporter
NE424_RS07485	COG2814	Major facilitator Superfamily
NE424_RS07595	COG0582	viral genome integration into host DNA
NE424_RS07605	COG1902	pentaerythritol trinitrate reductase activity
NE424_RS07605	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE424_RS07615	COG3706	GGDEF domain
NE424_RS07615	COG4251	negative regulation of phosphorylation
NE424_RS07615	COG5001	Diguanylate cyclase
NE424_RS07615	COG2203	Gaf domain
NE424_RS07625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NE424_RS07645	COG4172	Belongs to the ABC transporter superfamily
NE424_RS07650	COG4239	(ABC) transporter, permease
NE424_RS07655	COG4174	ABC transporter (Permease)
NE424_RS07665	COG0741	lytic transglycosylase activity
NE424_RS07665	COG1388	LysM domain
NE424_RS07665	COG0741	lytic transglycosylase activity
NE424_RS07665	COG1388	LysM domain
NE424_RS07670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NE424_RS07710	COG0583	DNA-binding transcription factor activity
NE424_RS07715	COG1279	arginine transmembrane transporter activity
NE424_RS07735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS07740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS07745	COG0006	proline dipeptidase activity
NE424_RS07785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NE424_RS07800	COG3384	dioxygenase
NE424_RS07810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NE424_RS07815	COG2878	Part of a membrane complex involved in electron transport
NE424_RS07820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NE424_RS07845	COG0768	penicillin binding
NE424_RS07850	COG0742	ribosomal rna small subunit methyltransferase
NE424_RS07865	COG0830	nickel cation binding
NE424_RS07875	COG0804	urea catabolic process
NE424_RS07915	COG1253	flavin adenine dinucleotide binding
NE424_RS07920	COG2851	Citrate transporter
NE424_RS07970	COG1773	rubredoxin
NE424_RS07975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE424_RS07985	COG0583	DNA-binding transcription factor activity
NE424_RS08015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NE424_RS08020	COG4181	ATPase activity
NE424_RS08065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NE424_RS08085	COG0306	phosphate transporter
NE424_RS08095	COG3958	Transketolase
NE424_RS08100	COG3959	Transketolase, thiamine diphosphate binding domain
NE424_RS08105	COG2271	Major facilitator Superfamily
NE424_RS08110	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS08115	COG0583	DNA-binding transcription factor activity
NE424_RS08130	COG2223	nitrite transmembrane transporter activity
NE424_RS08135	COG2207	Transcriptional regulator
NE424_RS08140	COG2066	Belongs to the glutaminase family
NE424_RS08145	COG0242	peptide deformylase activity
NE424_RS08150	COG0477	Major facilitator Superfamily
NE424_RS08160	COG0028	Belongs to the TPP enzyme family
NE424_RS08175	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS08180	COG2267	carboxylic ester hydrolase activity
NE424_RS08190	COG2271	Major facilitator Superfamily
NE424_RS08225	COG1414	Transcriptional regulator
NE424_RS08240	COG1024	Enoyl-CoA hydratase
NE424_RS08250	COG1215	transferase activity, transferring glycosyl groups
NE424_RS08255	COG0726	polysaccharide deacetylase
NE424_RS08255	COG1649	PFAM Uncharacterised BCR, COG1649
NE424_RS08265	COG4681	YaeQ
NE424_RS08275	COG0523	cobalamin synthesis protein
NE424_RS08285	COG1607	acyl-coa hydrolase
NE424_RS08295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE424_RS08300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE424_RS08305	COG1309	transcriptional regulator
NE424_RS08330	COG2040	homocysteine
NE424_RS08335	COG0531	amino acid
NE424_RS08365	COG0582	viral genome integration into host DNA
NE424_RS08375	COG0405	Gamma-glutamyltransferase
NE424_RS08380	COG2814	Major facilitator Superfamily
NE424_RS08385	COG1566	PFAM secretion protein HlyD family protein
NE424_RS08390	COG2050	protein possibly involved in aromatic compounds catabolism
NE424_RS08405	COG1090	epimerase
NE424_RS08425	COG0420	3'-5' exonuclease activity
NE424_RS08450	COG0735	belongs to the Fur family
NE424_RS08455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NE424_RS08475	COG0121	glutamine amidotransferase
NE424_RS08490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NE424_RS08500	COG0210	DNA helicase
NE424_RS08505	COG2885	chlorophyll binding
NE424_RS08510	COG0204	Acyl-transferase
NE424_RS08525	COG2894	cell division
NE424_RS08540	COG1280	lysine exporter protein (LysE YggA)
NE424_RS08545	COG1674	ftsk spoiiie
NE424_RS08545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NE424_RS08550	COG0492	ferredoxin-NADP+ reductase activity
NE424_RS08555	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NE424_RS08565	COG0456	acetyltransferase
NE424_RS08610	COG1981	membrane
NE424_RS08625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NE424_RS08625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NE424_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS08655	COG0657	acetylesterase activity
NE424_RS08665	COG0473	3-isopropylmalate dehydrogenase activity
NE424_RS08670	COG0583	DNA-binding transcription factor activity
NE424_RS08690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NE424_RS08700	COG0582	viral genome integration into host DNA
NE424_RS08805	COG3646	Phage regulatory protein
NE424_RS09060	COG0564	pseudouridine synthase activity
NE424_RS09070	COG0358	DNA primase activity
NE424_RS09085	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NE424_RS09115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NE424_RS09145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NE424_RS09155	COG0351	phosphomethylpyrimidine kinase
NE424_RS09155	COG0352	thiamine-phosphate diphosphorylase activity
NE424_RS09155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NE424_RS09160	COG1652	LysM domain
NE424_RS09185	COG1399	metal-binding, possibly nucleic acid-binding protein
NE424_RS09190	COG3101	peptidyl-lysine hydroxylation
NE424_RS09195	COG0009	L-threonylcarbamoyladenylate synthase
NE424_RS09200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NE424_RS09205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NE424_RS09220	COG4106	trans-aconitate 2-methyltransferase activity
NE424_RS09235	COG0596	Alpha beta hydrolase
NE424_RS09235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE424_RS09235	COG2226	methyltransferase
NE424_RS09240	COG1877	trehalose-phosphatase activity
NE424_RS09245	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NE424_RS09250	COG2223	nitrite transmembrane transporter activity
NE424_RS09270	COG1196	nuclear chromosome segregation
NE424_RS09280	COG0730	response to heat
NE424_RS09295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NE424_RS09305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NE424_RS09355	COG0489	protein tyrosine kinase activity
NE424_RS09365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE424_RS09365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE424_RS09395	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NE424_RS09400	COG2081	HI0933 family
NE424_RS09410	COG0668	transmembrane transport
NE424_RS09430	COG0583	DNA-binding transcription factor activity
NE424_RS09450	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NE424_RS09455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NE424_RS09485	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NE424_RS09525	COG0745	RESPONSE REGULATOR receiver
NE424_RS09545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NE424_RS09555	COG1301	dicarboxylic acid transport
NE424_RS09560	COG0583	DNA-binding transcription factor activity
NE424_RS09570	COG0697	spore germination
NE424_RS09605	COG2271	Major facilitator Superfamily
NE424_RS09620	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS09655	COG3621	Patatin-like phospholipase
NE424_RS09715	COG0384	phenazine biosynthesis protein PhzF
NE424_RS09740	COG5290	Psort location Cytoplasmic, score
NE424_RS09750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS09795	COG0583	DNA-binding transcription factor activity
NE424_RS09810	COG0583	DNA-binding transcription factor activity
NE424_RS09815	COG1053	succinate dehydrogenase
NE424_RS09825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NE424_RS09830	COG2814	Major facilitator Superfamily
NE424_RS09835	COG1960	acyl-CoA dehydrogenase activity
NE424_RS09840	COG0583	DNA-binding transcription factor activity
NE424_RS09845	COG1063	alcohol dehydrogenase
NE424_RS09875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NE424_RS09880	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NE424_RS09885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NE424_RS09905	COG2132	Multicopper oxidase
NE424_RS09915	COG0561	phosphatase activity
NE424_RS09920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NE424_RS09945	COG1214	PFAM Peptidase M22, glycoprotease
NE424_RS09990	COG1134	teichoic acid transport
NE424_RS09990	COG1388	LysM domain
NE424_RS09995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NE424_RS10005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NE424_RS10010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NE424_RS10015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NE424_RS10075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NE424_RS10085	COG1846	Transcriptional regulator
NE424_RS10090	COG1764	response to oxidative stress
NE424_RS10130	COG0037	tRNA processing
NE424_RS10140	COG0248	Ppx GppA phosphatase
NE424_RS10170	COG0072	phenylalanine-tRNA ligase activity
NE424_RS10215	COG1238	metal cluster binding
NE424_RS10220	COG0625	glutathione transferase activity
NE424_RS10235	COG0318	PFAM AMP-dependent synthetase and ligase
NE424_RS10240	COG3028	Belongs to the UPF0307 family
NE424_RS10245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NE424_RS10265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NE424_RS10270	COG0617	tRNA 3'-terminal CCA addition
NE424_RS10275	COG1555	photosystem II stabilization
NE424_RS10280	COG3956	TIGRFAM MazG family protein
NE424_RS10290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NE424_RS10310	COG0784	Response regulator, receiver
NE424_RS10310	COG2205	protein histidine kinase activity
NE424_RS10310	COG5002	protein histidine kinase activity
NE424_RS10315	COG1024	Enoyl-CoA hydratase
NE424_RS10320	COG2084	Dehydrogenase
NE424_RS10325	COG3622	Belongs to the hyi family
NE424_RS10355	COG0697	spore germination
NE424_RS10365	COG2814	Major facilitator Superfamily
NE424_RS10390	COG2072	flavoprotein involved in K transport
NE424_RS10395	COG0492	ferredoxin-NADP+ reductase activity
NE424_RS10400	COG0431	NADPH-dependent FMN reductase
NE424_RS10405	COG0798	PFAM Bile acid sodium symporter
NE424_RS10415	COG0640	Transcriptional regulator
NE424_RS10450	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NE424_RS10475	COG2132	Multicopper oxidase
NE424_RS10490	COG2205	protein histidine kinase activity
NE424_RS10575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NE424_RS10585	COG0583	DNA-binding transcription factor activity
NE424_RS10595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NE424_RS10605	COG0084	hydrolase, TatD family'
NE424_RS10620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NE424_RS10645	COG2130	NADP-dependent
NE424_RS10650	COG1309	transcriptional regulator
NE424_RS10670	COG1979	alcohol dehydrogenase
NE424_RS10680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NE424_RS10700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NE424_RS10705	COG0583	DNA-binding transcription factor activity
NE424_RS10710	COG4221	oxidoreductase activity
NE424_RS10905	COG0440	acetolactate synthase activity
NE424_RS10910	COG0028	Belongs to the TPP enzyme family
NE424_RS10935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS10940	COG1136	(ABC) transporter
NE424_RS10940	COG0577	efflux transmembrane transporter activity
NE424_RS10945	COG1538	Outer membrane efflux protein
NE424_RS10960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NE424_RS10965	COG1162	GTPase activity
NE424_RS10975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NE424_RS11015	COG1426	Protein conserved in bacteria
NE424_RS11050	COG0793	Belongs to the peptidase S41A family
NE424_RS11065	COG2267	carboxylic ester hydrolase activity
NE424_RS11075	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS11080	COG3265	gluconokinase activity
NE424_RS11090	COG0800	Aldolase
NE424_RS11100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NE424_RS11105	COG0857	belongs to the CobB CobQ family
NE424_RS11105	COG0280	phosphate acetyltransferase
NE424_RS11110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NE424_RS11110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NE424_RS11130	COG0740	serine-type endopeptidase activity
NE424_RS11140	COG4774	siderophore transport
NE424_RS11150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NE424_RS11160	COG2813	Specifically methylates the guanine in position
NE424_RS11160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NE424_RS11310	COG0788	formyltetrahydrofolate deformylase activity
NE424_RS11335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE424_RS11335	COG4651	solute:proton antiporter activity
NE424_RS11355	COG0724	RNA recognition motif
NE424_RS11360	COG0210	DNA helicase
NE424_RS11385	COG1733	regulation of RNA biosynthetic process
NE424_RS11395	COG2900	Belongs to the SlyX family
NE424_RS11400	COG0488	(ABC) transporter
NE424_RS11410	COG1280	lysine exporter protein (LysE YggA)
NE424_RS11415	COG1560	Kdo2-lipid A biosynthetic process
NE424_RS11425	COG1301	dicarboxylic acid transport
NE424_RS11480	COG0473	3-isopropylmalate dehydrogenase activity
NE424_RS11535	COG0583	DNA-binding transcription factor activity
NE424_RS11545	COG0625	glutathione transferase activity
NE424_RS11550	COG2378	regulation of single-species biofilm formation
NE424_RS11555	COG0546	phosphoglycolate phosphatase activity
NE424_RS11565	COG1530	ribonuclease E activity
NE424_RS11570	COG0318	PFAM AMP-dependent synthetase and ligase
NE424_RS11585	COG0583	DNA-binding transcription factor activity
NE424_RS11590	COG4221	oxidoreductase activity
NE424_RS11595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NE424_RS11605	COG0534	Mate efflux family protein
NE424_RS11620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NE424_RS11660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NE424_RS11665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE424_RS11680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NE424_RS11690	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NE424_RS11690	COG0644	oxidoreductase
NE424_RS11700	COG0425	Belongs to the sulfur carrier protein TusA family
NE424_RS11705	COG4535	Mg2 and Co2 transporter CorC
NE424_RS11715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NE424_RS11735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NE424_RS11740	COG0475	glutathione-regulated potassium exporter activity
NE424_RS11740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NE424_RS11755	COG0484	heat shock protein binding
NE424_RS11760	COG0789	Transcriptional regulator
NE424_RS11765	COG0598	Magnesium transport protein CorA
NE424_RS11780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NE424_RS11785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE424_RS11790	COG1074	ATP-dependent DNA helicase activity
NE424_RS11795	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NE424_RS11815	COG2226	methyltransferase
NE424_RS11825	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NE424_RS11830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS11840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NE424_RS11855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NE424_RS11855	COG2111	Na H antiporter
NE424_RS11860	COG1006	Multisubunit Na H antiporter MnhC subunit
NE424_RS11865	COG0651	ATP synthesis coupled electron transport
NE424_RS11870	COG1863	multisubunit Na H antiporter MnhE subunit
NE424_RS11875	COG2212	antiporter activity
NE424_RS11880	COG1320	monovalent cation:proton antiporter activity
NE424_RS11895	COG0195	Participates in both transcription termination and antitermination
NE424_RS11945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NE424_RS11950	COG0237	dephospho-CoA kinase activity
NE424_RS11960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NE424_RS11975	COG0497	DNA recombination
NE424_RS11985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NE424_RS12015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NE424_RS12015	COG2169	Transcriptional regulator
NE424_RS12020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NE424_RS12090	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NE424_RS12105	COG0326	Molecular chaperone. Has ATPase activity
NE424_RS12120	COG2056	Na+-H+ antiporter family
NE424_RS12220	COG0546	phosphoglycolate phosphatase activity
NE424_RS12225	COG1716	ATPase activity
NE424_RS12270	COG0181	hydroxymethylbilane synthase activity
NE424_RS12280	COG3275	phosphorelay sensor kinase activity
NE424_RS12300	COG1538	Outer membrane efflux protein
NE424_RS12305	COG0697	spore germination
NE424_RS12330	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NE424_RS12335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NE424_RS12340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NE424_RS12345	COG0772	Belongs to the SEDS family
NE424_RS12370	COG4974	Belongs to the 'phage' integrase family
NE424_RS12375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE424_RS12385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NE424_RS12395	COG2197	response regulator
NE424_RS12410	COG0793	Belongs to the peptidase S41A family
NE424_RS12415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NE424_RS12420	COG0795	lipopolysaccharide-transporting ATPase activity
NE424_RS12460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NE424_RS12460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NE424_RS12470	COG0004	ammonium transporteR
NE424_RS12475	COG0347	Belongs to the P(II) protein family
NE424_RS12485	COG0606	chelatase, subunit chli
NE424_RS12500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE424_RS12520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NE424_RS12535	COG0318	PFAM AMP-dependent synthetase and ligase
NE424_RS12545	COG0477	Major facilitator Superfamily
NE424_RS12550	COG2860	membrane
NE424_RS12560	COG1253	flavin adenine dinucleotide binding
NE424_RS12570	COG0477	Major facilitator Superfamily
NE424_RS12580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NE424_RS12620	COG0655	NAD(P)H dehydrogenase (quinone) activity
NE424_RS12630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NE424_RS12700	COG0758	DNA mediated transformation
NE424_RS12710	COG0697	spore germination
NE424_RS12715	COG1309	transcriptional regulator
NE424_RS12730	COG0386	Belongs to the glutathione peroxidase family
NE424_RS12795	COG1121	(ABC) transporter
NE424_RS12800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NE424_RS12805	COG1280	lysine exporter protein (LysE YggA)
NE424_RS12810	COG2837	iron assimilation
NE424_RS12815	COG0281	malic enzyme
NE424_RS12860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NE424_RS12860	COG0519	Catalyzes the synthesis of GMP from XMP
NE424_RS12865	COG4399	Belongs to the UPF0754 family
NE424_RS12870	COG2259	Doxx family
NE424_RS12875	COG0586	Pfam SNARE associated Golgi protein
NE424_RS12890	COG1192	Involved in chromosome partitioning
NE424_RS12900	COG0271	Belongs to the BolA IbaG family
NE424_RS12940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NE424_RS12940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NE424_RS12940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NE424_RS12940	COG3321	synthase
NE424_RS12945	COG1960	acyl-CoA dehydrogenase activity
NE424_RS12955	COG2197	response regulator
NE424_RS12965	COG3916	Acyl-homoserine-lactone synthase
NE424_RS12970	COG0477	Major facilitator Superfamily
NE424_RS12975	COG1024	Enoyl-CoA hydratase
NE424_RS12980	COG1024	Enoyl-CoA hydratase
NE424_RS12985	COG1960	acyl-CoA dehydrogenase activity
NE424_RS12990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE424_RS13010	COG1113	amino acid transport
NE424_RS13015	COG1113	amino acid transport
NE424_RS13020	COG0251	oxidation-reduction process
NE424_RS13060	COG0564	pseudouridine synthase activity
NE424_RS13165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NE424_RS13180	COG1802	Transcriptional regulator
NE424_RS13190	COG1448	Aminotransferase
NE424_RS13195	COG0277	FAD linked oxidase domain protein
NE424_RS13205	COG2186	Transcriptional regulator
NE424_RS13215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NE424_RS13225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NE424_RS13240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NE424_RS13245	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NE424_RS13250	COG1216	Glycosyl transferase, family 2
NE424_RS13260	COG1216	Glycosyl transferase, family 2
NE424_RS13270	COG1442	glycosyl transferase family 8
NE424_RS13270	COG1216	Glycosyl transferase, family 2
NE424_RS13280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NE424_RS13285	COG1596	polysaccharide export
NE424_RS13310	COG0728	peptidoglycan biosynthetic process
NE424_RS13315	COG3023	N-Acetylmuramoyl-L-alanine amidase
NE424_RS13370	COG0546	phosphoglycolate phosphatase activity
NE424_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS13395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE424_RS13400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NE424_RS13405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS13410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NE424_RS13415	COG1116	anion transmembrane transporter activity
NE424_RS13420	COG1309	transcriptional regulator
NE424_RS13425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NE424_RS13435	COG0196	riboflavin kinase activity
NE424_RS13440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NE424_RS13450	COG1047	Peptidyl-prolyl cis-trans
NE424_RS13490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NE424_RS13495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NE424_RS13500	COG0596	Alpha beta hydrolase
NE424_RS13525	COG0488	(ABC) transporter
NE424_RS13530	COG0586	Pfam SNARE associated Golgi protein
NE424_RS13540	COG0187	DNA topoisomerase II activity
NE424_RS13550	COG0592	DNA-directed DNA polymerase activity
NE424_RS13575	COG0706	membrane insertase activity
NE424_RS13590	COG1230	cation diffusion facilitator family transporter
NE424_RS13595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE424_RS13610	COG0402	S-adenosylhomocysteine deaminase activity
NE424_RS13620	COG0754	glutathionylspermidine amidase activity
NE424_RS13630	COG0861	Integral membrane protein TerC family
NE424_RS13635	COG0671	phosphoesterase, PA-phosphatase related
NE424_RS13645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NE424_RS13660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NE424_RS13665	COG2951	lytic endotransglycosylase activity
NE424_RS13695	COG0583	DNA-binding transcription factor activity
NE424_RS13715	COG0657	acetylesterase activity
NE424_RS13720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NE424_RS13760	COG0733	neurotransmitter:sodium symporter activity
NE424_RS13795	COG0583	DNA-binding transcription factor activity
NE424_RS13800	COG2233	PERMEase
NE424_RS13815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS13850	COG2814	Major facilitator Superfamily
NE424_RS13855	COG0656	L-ascorbic acid biosynthetic process
NE424_RS13860	COG0583	DNA-binding transcription factor activity
NE424_RS13875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE424_RS13880	COG1064	alcohol dehydrogenase
NE424_RS13885	COG2818	Glycosylase
NE424_RS13900	COG1194	a g-specific adenine glycosylase
NE424_RS13920	COG2983	Belongs to the UPF0260 family
NE424_RS13925	COG2133	pyrroloquinoline quinone binding
NE424_RS13930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NE424_RS13935	COG2116	formate transmembrane transporter activity
NE424_RS13955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NE424_RS13960	COG1335	isochorismatase
NE424_RS13965	COG0385	Bile acid
NE424_RS13970	COG0534	Mate efflux family protein
NE424_RS13975	COG1683	Conserved Protein
NE424_RS13995	COG0625	glutathione transferase activity
NE424_RS14005	COG1113	amino acid transport
NE424_RS14015	COG0523	cobalamin synthesis protein
NE424_RS14025	COG2188	Transcriptional regulator
NE424_RS14055	COG0010	Belongs to the arginase family
NE424_RS14070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NE424_RS14085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NE424_RS14095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NE424_RS14100	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NE424_RS14185	COG0534	Mate efflux family protein
NE424_RS14190	COG0436	Aminotransferase
NE424_RS14195	COG2733	membrane
NE424_RS14210	COG2918	glutathione biosynthetic process
NE424_RS14225	COG5632	N-Acetylmuramoyl-L-alanine amidase
NE424_RS14225	COG1388	LysM domain
NE424_RS14225	COG3409	Peptidoglycan-binding domain 1 protein
NE424_RS14270	COG3150	esterase
NE424_RS14280	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS14285	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NE424_RS14295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NE424_RS14305	COG2233	PERMEase
NE424_RS14310	COG2351	hydroxyisourate hydrolase activity
NE424_RS14345	COG3706	GGDEF domain
NE424_RS14360	COG1393	Belongs to the ArsC family
NE424_RS14365	COG0708	Exodeoxyribonuclease III
NE424_RS14390	COG0189	ligase activity
NE424_RS14410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NE424_RS14420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NE424_RS14435	COG4942	peptidase
NE424_RS14445	COG0508	dehydrogenase complex catalyzes the overall conversion of
NE424_RS14455	COG2119	membrane
NE424_RS14460	COG4774	siderophore transport
NE424_RS14465	COG0426	domain, Protein
NE424_RS14465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS14490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NE424_RS14510	COG1902	pentaerythritol trinitrate reductase activity
NE424_RS14515	COG1519	Transferase
NE424_RS14520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NE424_RS14525	COG0668	transmembrane transport
NE424_RS14535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NE424_RS14540	COG1335	isochorismatase
NE424_RS14545	COG1522	sequence-specific DNA binding
NE424_RS14570	COG2198	Histidine kinase
NE424_RS14570	COG2205	protein histidine kinase activity
NE424_RS14570	COG0784	Response regulator, receiver
NE424_RS14575	COG3162	membrane
NE424_RS14580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NE424_RS14590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE424_RS14610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NE424_RS14615	COG1309	transcriptional regulator
NE424_RS14635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NE424_RS14635	COG0352	thiamine-phosphate diphosphorylase activity
NE424_RS14635	COG0351	phosphomethylpyrimidine kinase
NE424_RS14645	COG2814	Major facilitator Superfamily
NE424_RS14660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NE424_RS14670	COG1113	amino acid transport
NE424_RS14680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NE424_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS14695	COG1335	isochorismatase
NE424_RS14725	COG2814	Major facilitator Superfamily
NE424_RS14730	COG0583	DNA-binding transcription factor activity
NE424_RS14750	COG0667	Aldo Keto reductase
NE424_RS14785	COG1733	regulation of RNA biosynthetic process
NE424_RS14790	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE424_RS14855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NE424_RS14870	COG2329	Antibiotic biosynthesis monooxygenase
NE424_RS14900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NE424_RS14930	COG0427	acetyl-CoA hydrolase
NE424_RS14955	COG0659	secondary active sulfate transmembrane transporter activity
NE424_RS14960	COG4221	oxidoreductase activity
NE424_RS14970	COG0488	(ABC) transporter
NE424_RS15055	COG0833	amino acid
NE424_RS15100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NE424_RS15105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NE424_RS15120	COG2226	methyltransferase
NE424_RS15170	COG0067	glutamate synthase
NE424_RS15170	COG0069	glutamate synthase activity
NE424_RS15170	COG0070	glutamate synthase
NE424_RS15175	COG0493	'glutamate synthase
NE424_RS15185	COG1704	LemA family
NE424_RS15190	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NE424_RS15205	COG3307	-O-antigen
NE424_RS15225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NE424_RS15240	COG0194	GDP metabolic process
NE424_RS15290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NE424_RS15310	COG5380	lipid catabolic process
NE424_RS15315	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NE424_RS15340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NE424_RS15345	COG0277	FAD linked oxidase domain protein
NE424_RS15365	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NE424_RS15370	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE424_RS15385	COG1289	transmembrane transporter activity
NE424_RS15395	COG0628	permease
NE424_RS15400	COG1192	Involved in chromosome partitioning
NE424_RS15430	COG0833	amino acid
NE424_RS15435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NE424_RS15440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NE424_RS15450	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS15490	COG0583	DNA-binding transcription factor activity
NE424_RS15510	COG1106	Psort location Cytoplasmic, score
NE424_RS15545	COG0517	IMP dehydrogenase activity
NE424_RS15550	COG1983	PspC domain protein
NE424_RS15560	COG1960	acyl-CoA dehydrogenase activity
NE424_RS15575	COG0408	coproporphyrinogen oxidase activity
NE424_RS15595	COG0513	Belongs to the DEAD box helicase family
NE424_RS15605	COG1127	ABC transporter
NE424_RS15610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NE424_RS15620	COG2854	intermembrane phospholipid transfer
NE424_RS15630	COG0598	Magnesium transport protein CorA
NE424_RS15640	COG0494	nUDIX hydrolase
NE424_RS15645	COG1040	competence protein
NE424_RS15650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NE424_RS15670	COG1946	Acyl-CoA thioesterase
NE424_RS15675	COG1301	dicarboxylic acid transport
NE424_RS15690	COG1959	2 iron, 2 sulfur cluster binding
NE424_RS15695	COG1017	nitric oxide dioxygenase activity
NE424_RS15695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS15705	COG0433	COG0433 Predicted ATPase
NE424_RS15865	COG1960	acyl-CoA dehydrogenase activity
NE424_RS15870	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NE424_RS15900	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NE424_RS15905	COG0339	signal peptide processing
NE424_RS15910	COG0557	exoribonuclease II activity
NE424_RS15955	COG0179	Fumarylacetoacetate (FAA) hydrolase
NE424_RS15960	COG2169	Transcriptional regulator
NE424_RS15965	COG0697	spore germination
NE424_RS15970	COG1295	ribonuclease BN
NE424_RS16005	COG1702	phosphate starvation-inducible protein PhoH
NE424_RS16015	COG0739	heme binding
NE424_RS16015	COG0741	lytic transglycosylase activity
NE424_RS16015	COG1196	nuclear chromosome segregation
NE424_RS16045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NE424_RS16050	COG1183	phosphatidylcholine synthase activity
NE424_RS16095	COG1960	acyl-CoA dehydrogenase activity
NE424_RS16100	COG1309	transcriptional regulator
NE424_RS16115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NE424_RS16120	COG1960	acyl-CoA dehydrogenase activity
NE424_RS16140	COG2969	positive regulation of protein catabolic process
NE424_RS16150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NE424_RS16165	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NE424_RS16170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NE424_RS16190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NE424_RS16200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NE424_RS16205	COG1408	metallophosphoesterase
NE424_RS16215	COG2199	diguanylate cyclase activity
NE424_RS16275	COG1607	acyl-coa hydrolase
NE424_RS16305	COG2350	Protein conserved in bacteria
NE424_RS16315	COG0613	PHP domain protein
NE424_RS16320	COG3781	membrane
NE424_RS16330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NE424_RS16335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NE424_RS16345	COG1862	Preprotein translocase
NE424_RS16380	COG2205	protein histidine kinase activity
NE424_RS16385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NE424_RS16400	COG0726	polysaccharide deacetylase
NE424_RS16420	COG1091	dTDP-4-dehydrorhamnose reductase activity
NE424_RS16435	COG1215	transferase activity, transferring glycosyl groups
NE424_RS16485	COG1960	acyl-CoA dehydrogenase activity
NE424_RS16490	COG1960	acyl-CoA dehydrogenase activity
NE424_RS16500	COG2205	protein histidine kinase activity
NE424_RS16505	COG0745	RESPONSE REGULATOR receiver
NE424_RS16510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NE424_RS16530	COG2096	Adenosyltransferase
NE424_RS16580	COG0285	dihydrofolate synthase activity
NE424_RS16600	COG0450	alkyl hydroperoxide reductase
NE424_RS16615	COG0477	Major facilitator Superfamily
NE424_RS16620	COG1272	protein, Hemolysin III
NE424_RS16650	COG0183	Belongs to the thiolase family
NE424_RS16655	COG2207	Transcriptional regulator
NE424_RS16675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE424_RS16695	COG0183	Belongs to the thiolase family
NE424_RS16705	COG2885	chlorophyll binding
NE424_RS16705	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NE424_RS16715	COG1690	Belongs to the RtcB family
NE424_RS16720	COG0833	amino acid
NE424_RS16730	COG2233	PERMEase
NE424_RS16735	COG1217	gtp-binding protein TYPA
NE424_RS16760	COG2094	Belongs to the DNA glycosylase MPG family
NE424_RS16765	COG4772	TonB-dependent receptor
NE424_RS16770	COG1902	pentaerythritol trinitrate reductase activity
NE424_RS16785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NE424_RS16790	COG0354	folic acid binding
NE424_RS16800	COG3189	MarR family transcriptional regulator
NE424_RS16805	COG2824	Alkylphosphonate utilization operon protein PhnA
NE424_RS16810	COG3422	double-strand break repair
NE424_RS16850	COG0840	transmembrane signaling receptor activity
NE424_RS16870	COG5510	response to toxic substance
NE424_RS16880	COG2832	Protein of unknown function (DUF454)
NE424_RS16885	COG1376	ErfK ybiS ycfS ynhG family protein
NE424_RS16925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NE424_RS16935	COG1289	transmembrane transporter activity
NE424_RS16940	COG2814	Major facilitator Superfamily
NE424_RS16960	COG1115	amino acid carrier protein
NE424_RS16965	COG1752	Esterase of the alpha-beta hydrolase superfamily
NE424_RS16970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NE424_RS16975	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NE424_RS16980	COG3590	peptidase
NE424_RS17010	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NE424_RS17020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NE424_RS17025	COG1077	Cell shape determining protein MreB Mrl
NE424_RS17030	COG1792	Involved in formation and maintenance of cell shape
NE424_RS17035	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NE424_RS17040	COG0424	maF-like protein
NE424_RS17045	COG1530	ribonuclease E activity
NE424_RS17055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE424_RS17065	COG0560	Phosphoserine phosphatase
NE424_RS17075	COG2249	NAD(P)H dehydrogenase (quinone) activity
NE424_RS17100	COG2207	Transcriptional regulator
NE424_RS17120	COG1113	amino acid transport
NE424_RS17125	COG2828	Protein conserved in bacteria
NE424_RS17130	COG0142	geranyltranstransferase activity
NE424_RS17135	COG2315	Protein conserved in bacteria
NE424_RS17150	COG1752	Esterase of the alpha-beta hydrolase superfamily
NE424_RS17170	COG2194	sulfuric ester hydrolase activity
NE424_RS17175	COG0745	RESPONSE REGULATOR receiver
NE424_RS17180	COG0642	Histidine kinase
NE424_RS17190	COG0004	ammonium transporteR
NE424_RS17195	COG0583	DNA-binding transcription factor activity
NE424_RS17215	COG0525	valine-tRNA ligase activity
NE424_RS17225	COG1028	Short-chain dehydrogenase reductase Sdr
NE424_RS17235	COG0393	Putative heavy-metal-binding
NE424_RS17240	COG0393	Putative heavy-metal-binding
NE424_RS17245	COG1538	Outer membrane efflux protein
NE424_RS17255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS17260	COG0671	phosphoesterase, PA-phosphatase related
NE424_RS17290	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NE424_RS17305	COG1648	precorrin-2 dehydrogenase activity
NE424_RS17305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NE424_RS17310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NE424_RS17315	COG1733	regulation of RNA biosynthetic process
NE424_RS17325	COG0531	amino acid
NE424_RS17340	COG0321	lipoyl(octanoyl) transferase activity
NE424_RS17345	COG2921	Belongs to the UPF0250 family
NE424_RS17380	COG2009	succinate dehydrogenase
NE424_RS17385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NE424_RS17390	COG1053	succinate dehydrogenase
NE424_RS17395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NE424_RS17420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE424_RS17440	COG2354	Protein conserved in bacteria
NE424_RS17445	COG2321	neutral zinc metallopeptidase
NE424_RS17465	COG2843	Capsule synthesis protein
NE424_RS17480	COG0589	response to stress
NE424_RS17500	COG0505	Belongs to the CarA family
NE424_RS17525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NE424_RS17530	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NE424_RS17580	COG0477	Major facilitator Superfamily
NE424_RS17585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NE424_RS17600	COG1597	lipid kinase activity
NE424_RS17605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NE424_RS17625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NE424_RS17630	COG0584	glycerophosphoryl diester phosphodiesterase
NE424_RS17650	COG0741	lytic transglycosylase activity
NE424_RS17670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NE424_RS17680	COG0583	DNA-binding transcription factor activity
NE424_RS17685	COG2851	Citrate transporter
NE424_RS17725	COG2076	Multidrug Resistance protein
NE424_RS17730	COG0004	ammonium transporteR
NE424_RS17735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE424_RS17740	COG3850	Histidine kinase
NE424_RS17745	COG2197	response regulator
NE424_RS17765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS17775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE424_RS17780	COG0347	Belongs to the P(II) protein family
NE424_RS17795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NE424_RS17810	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NE424_RS17810	COG0446	pyridine nucleotide-disulphide oxidoreductase
NE424_RS17820	COG0004	ammonium transporteR
NE424_RS17835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NE424_RS17840	COG2218	PFAM glutamate synthase alpha subunit domain protein
NE424_RS17845	COG0069	glutamate synthase activity
NE424_RS17925	COG2233	PERMEase
NE424_RS17930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NE424_RS17935	COG0251	oxidation-reduction process
NE424_RS17940	COG1335	isochorismatase
NE424_RS17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NE424_RS17950	COG0778	Nitroreductase
NE424_RS17955	COG0596	Alpha beta hydrolase
NE424_RS17970	COG0582	viral genome integration into host DNA
NE424_RS17980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE424_RS17990	COG3811	Belongs to the UPF0386 family
NE424_RS18010	COG0778	Nitroreductase
NE424_RS18025	COG1929	Belongs to the glycerate kinase type-1 family
NE424_RS18030	COG0243	molybdopterin cofactor binding
NE424_RS18035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NE424_RS18040	COG3339	Conserved Protein
NE424_RS18050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NE424_RS18065	COG1113	amino acid transport
NE424_RS18075	COG0019	diaminopimelate decarboxylase activity
NE424_RS18085	COG1280	lysine exporter protein (LysE YggA)
NE424_RS18090	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NE424_RS18120	COG0463	Glycosyl transferase, family 2
NE424_RS18140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS18175	COG4591	ABC-type transport system involved in lipoprotein release permease component
NE424_RS18180	COG1136	(ABC) transporter
NE424_RS18185	COG0658	competence protein
NE424_RS18185	COG2333	competence protein COMEC
NE424_RS18195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NE424_RS18195	COG0616	signal peptide processing
NE424_RS18200	COG0596	Alpha beta hydrolase
NE424_RS18205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NE424_RS18215	COG0628	permease
NE424_RS18250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NE424_RS18270	COG0823	Involved in the tonB-independent uptake of proteins
NE424_RS18290	COG0824	Thioesterase
NE424_RS18295	COG1473	amidohydrolase
NE424_RS18315	COG0047	phosphoribosylformylglycinamidine synthase activity
NE424_RS18315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NE424_RS18320	COG2814	Major facilitator Superfamily
NE424_RS18335	COG1024	Enoyl-CoA hydratase
NE424_RS18340	COG1051	belongs to the nudix hydrolase family
NE424_RS18340	COG1056	cytidyltransferase-related domain
NE424_RS18350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NE424_RS18365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NE424_RS18380	COG4625	pathogenesis
NE424_RS18390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NE424_RS18395	COG4208	sulfate ABC transporter
NE424_RS18400	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NE424_RS18410	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NE424_RS18415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NE424_RS18420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NE424_RS18440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NE424_RS18450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NE424_RS18460	COG0681	Belongs to the peptidase S26 family
NE424_RS18475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NE424_RS18485	COG1381	Involved in DNA repair and RecF pathway recombination
NE424_RS18490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NE424_RS18500	COG4221	oxidoreductase activity
NE424_RS18530	COG0436	Aminotransferase
NE424_RS18550	COG0556	nucleotide-excision repair
NE424_RS18605	COG2070	2-Nitropropane dioxygenase
NE424_RS18635	COG1215	transferase activity, transferring glycosyl groups
NE424_RS18650	COG0415	Belongs to the DNA photolyase family
NE424_RS18660	COG1252	NADH dehydrogenase
NE424_RS18665	COG1686	Belongs to the peptidase S11 family
NE424_RS18680	COG1187	pseudouridine synthase activity
NE424_RS18700	COG0477	Major facilitator Superfamily
NE424_RS18705	COG0583	DNA-binding transcription factor activity
NE424_RS18710	COG1823	symporter activity
NE424_RS18720	COG0612	Peptidase, M16
NE424_RS18750	COG1203	CRISPR-associated helicase, Cas3
NE424_RS18775	COG0352	thiamine-phosphate diphosphorylase activity
NE424_RS18810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NE424_RS18825	COG1309	transcriptional regulator
NE424_RS18835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NE424_RS18840	COG0076	glutamate decarboxylase activity
NE424_RS18850	COG1522	sequence-specific DNA binding
NE424_RS18855	COG3961	Belongs to the TPP enzyme family
NE424_RS18860	COG1113	amino acid transport
NE424_RS18865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NE424_RS18870	COG0573	inorganic phosphate transmembrane transporter activity
NE424_RS18880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NE424_RS18885	COG0616	signal peptide processing
NE424_RS18920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NE424_RS18925	COG1686	Belongs to the peptidase S11 family
NE424_RS18950	COG0583	DNA-binding transcription factor activity
NE424_RS18955	COG1067	ATP-dependent peptidase activity
NE424_RS18960	COG2211	Major facilitator Superfamily
NE424_RS18980	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NE424_RS19000	COG1966	Carbon starvation protein
NE424_RS19005	COG2879	small protein
NE424_RS19015	COG0583	DNA-binding transcription factor activity
NE424_RS19020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NE424_RS19035	COG1012	belongs to the aldehyde dehydrogenase family
NE424_RS19045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NE424_RS19050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NE424_RS19050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NE424_RS19085	COG4948	Mandelate Racemase Muconate Lactonizing
NE424_RS19095	COG1309	transcriptional regulator
NE424_RS19100	COG1309	transcriptional regulator
NE424_RS19115	COG1741	Belongs to the pirin family
NE424_RS19125	COG2964	Protein conserved in bacteria
NE424_RS19140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE424_RS19145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NE424_RS19150	COG4605	iron ion homeostasis
NE424_RS19155	COG4604	ABC transporter, ATP-binding protein
NE424_RS19160	COG4607	ABC-type enterochelin transport system periplasmic component
NE424_RS19165	COG4774	siderophore transport
NE424_RS19175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NE424_RS19180	COG1021	2,3-dihydroxybenzoate-AMP ligase
NE424_RS19185	COG3433	isochorismatase activity
NE424_RS19185	COG1535	isochorismatase
NE424_RS19200	COG1132	(ABC) transporter
NE424_RS19205	COG1132	(ABC) transporter
NE424_RS19210	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NE424_RS19215	COG2977	Belongs to the P-Pant transferase superfamily
NE424_RS19220	COG1169	isochorismate synthase
NE424_RS19235	COG3739	integral membrane protein
NE424_RS19255	COG0302	gtp cyclohydrolase
NE424_RS19265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NE424_RS19275	COG2840	Smr protein MutS2
NE424_RS19295	COG0308	aminopeptidase N
NE424_RS19300	COG0512	Glutamine amidotransferase of anthranilate synthase
NE424_RS19315	COG0174	glutamine synthetase
NE424_RS19325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NE424_RS19430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NE424_RS19450	COG2369	cell adhesion
NE424_RS19455	COG0582	viral genome integration into host DNA
NE424_RS19460	COG0789	Transcriptional regulator
NE424_RS19470	COG1230	cation diffusion facilitator family transporter
NE424_RS19500	COG0789	Transcriptional regulator
NE424_RS19530	COG2207	Transcriptional regulator
NE424_RS19535	COG0633	Ferredoxin
NE424_RS19565	COG1309	transcriptional regulator
NE424_RS19610	COG1373	ATPase (AAA superfamily
NE424_RS19750	COG2801	Transposase and inactivated derivatives
NE424_RS19755	COG3173	Aminoglycoside phosphotransferase
NE424_RS19760	COG0488	(ABC) transporter
NE424_RS19780	COG3328	transposase activity
NE424_RS19785	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NE424_RS19790	COG3657	addiction module killer protein
NE424_RS19820	COG2826	transposase and inactivated derivatives, IS30 family
NE424_RS19830	COG2826	transposase and inactivated derivatives, IS30 family
NE424_RS19865	COG2076	Multidrug Resistance protein
NE424_RS19940	COG2184	nucleotidyltransferase activity
NE424_RS19965	COG2826	transposase and inactivated derivatives, IS30 family
NE424_RS19990	COG1324	tolerance protein
NE424_RS20020	COG2826	transposase and inactivated derivatives, IS30 family
NE424_RS20040	COG1475	DNA binding
NE424_RS20045	COG1192	Involved in chromosome partitioning
NE424_RS20060	COG0789	Transcriptional regulator
NE424_RS20115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NE424_RS20120	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NE424_RS20125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NE424_RS20145	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NE424_RS20150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NE424_RS20155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NE424_RS20170	COG1960	acyl-CoA dehydrogenase activity
NE424_RS20175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NE424_RS20180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NE424_RS20190	COG2223	nitrite transmembrane transporter activity
NE424_RS20200	COG0024	Methionine aminopeptidase
NE424_RS20205	COG0052	Belongs to the universal ribosomal protein uS2 family
NE424_RS20220	COG2207	Transcriptional regulator
NE424_RS20245	COG2951	lytic endotransglycosylase activity
NE424_RS20250	COG0772	Belongs to the SEDS family
NE424_RS20265	COG0842	Transport permease protein
NE424_RS20270	COG1131	(ABC) transporter
NE424_RS20315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NE424_RS20330	COG4215	(ABC) transporter
NE424_RS20335	COG4160	amino acid transport
NE424_RS20340	COG4598	ABC transporter
NE424_RS20350	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NE424_RS20355	COG0826	peptidase U32
NE424_RS20360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NE424_RS20375	COG1720	tRNA m6t6A37 methyltransferase activity
NE424_RS20385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NE424_RS20400	COG0642	Histidine kinase
NE424_RS20410	COG0494	nUDIX hydrolase
NE424_RS20420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NE424_RS20425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NE424_RS20430	COG3139	Protein of unknown function (DUF1315)
NE424_RS20435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NE424_RS20440	COG1301	dicarboxylic acid transport
NE424_RS20445	COG1960	acyl-CoA dehydrogenase activity
NE424_RS20450	COG2819	hydrolase of the alpha beta superfamily
NE424_RS20460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NE424_RS20470	COG2195	Cleaves the N-terminal amino acid of tripeptides
NE424_RS20490	COG1690	Belongs to the RtcB family
NE424_RS20495	COG1234	tRNA 3'-trailer cleavage
NE424_RS20500	COG4650	regulator
NE424_RS20530	COG2363	Small membrane protein
NE424_RS20555	COG0513	Belongs to the DEAD box helicase family
NE424_RS20565	COG0778	Nitroreductase
NE424_RS20595	COG1286	toxin biosynthetic process
NE424_RS20620	COG4783	chaperone-mediated protein folding
NE424_RS20625	COG1610	YqeY-like protein
NE424_RS20655	COG2815	serine threonine protein kinase
NE424_RS20655	COG0515	serine threonine protein kinase
NE424_RS20680	COG2831	hemolysin activation secretion protein
NE424_RS20685	COG3210	domain, Protein
NE424_RS20685	COG3210	domain, Protein