locus-tag	class	description
HBM78_RS00010	COG0592	DNA-directed DNA polymerase activity
HBM78_RS00020	COG0187	DNA topoisomerase II activity
HBM78_RS00030	COG0586	Pfam SNARE associated Golgi protein
HBM78_RS00035	COG0488	(ABC) transporter
HBM78_RS00060	COG0596	Alpha beta hydrolase
HBM78_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HBM78_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBM78_RS00115	COG0733	neurotransmitter:sodium symporter activity
HBM78_RS00155	COG2233	PERMEase
HBM78_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS00205	COG2814	Major facilitator Superfamily
HBM78_RS00210	COG0656	L-ascorbic acid biosynthetic process
HBM78_RS00215	COG0583	DNA-binding transcription factor activity
HBM78_RS00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_RS00235	COG1064	alcohol dehydrogenase
HBM78_RS00240	COG2818	Glycosylase
HBM78_RS00255	COG1194	a g-specific adenine glycosylase
HBM78_RS00275	COG2983	Belongs to the UPF0260 family
HBM78_RS00280	COG2133	pyrroloquinoline quinone binding
HBM78_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBM78_RS00290	COG2116	formate transmembrane transporter activity
HBM78_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_RS00315	COG1335	isochorismatase
HBM78_RS00320	COG0385	Bile acid
HBM78_RS00325	COG0534	Mate efflux family protein
HBM78_RS00330	COG1683	Conserved Protein
HBM78_RS00350	COG0625	glutathione transferase activity
HBM78_RS00360	COG1113	amino acid transport
HBM78_RS00370	COG0523	cobalamin synthesis protein
HBM78_RS00380	COG2188	Transcriptional regulator
HBM78_RS00410	COG0010	Belongs to the arginase family
HBM78_RS00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM78_RS00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBM78_RS00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBM78_RS00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBM78_RS00545	COG0534	Mate efflux family protein
HBM78_RS00550	COG0436	Aminotransferase
HBM78_RS00555	COG2733	membrane
HBM78_RS00570	COG2918	glutathione biosynthetic process
HBM78_RS00580	COG3501	Rhs element vgr protein
HBM78_RS00585	COG0791	NLP P60 protein
HBM78_RS00585	COG1388	LysM domain
HBM78_RS00600	COG3150	esterase
HBM78_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HBM78_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_RS00635	COG2233	PERMEase
HBM78_RS00640	COG2351	hydroxyisourate hydrolase activity
HBM78_RS00675	COG3706	GGDEF domain
HBM78_RS00690	COG1393	Belongs to the ArsC family
HBM78_RS00695	COG0708	Exodeoxyribonuclease III
HBM78_RS00715	COG0189	ligase activity
HBM78_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HBM78_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBM78_RS00760	COG4942	peptidase
HBM78_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM78_RS00780	COG2119	membrane
HBM78_RS00785	COG4774	siderophore transport
HBM78_RS00790	COG0426	domain, Protein
HBM78_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBM78_RS00835	COG1902	pentaerythritol trinitrate reductase activity
HBM78_RS00840	COG1519	Transferase
HBM78_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM78_RS00850	COG0668	transmembrane transport
HBM78_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_RS00865	COG1335	isochorismatase
HBM78_RS00870	COG1522	sequence-specific DNA binding
HBM78_RS00875	COG3328	transposase activity
HBM78_RS00900	COG2205	protein histidine kinase activity
HBM78_RS00900	COG0784	Response regulator, receiver
HBM78_RS00900	COG2198	Histidine kinase
HBM78_RS00905	COG3162	membrane
HBM78_RS00910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM78_RS00920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_RS00930	COG3706	GGDEF domain
HBM78_RS00940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HBM78_RS00945	COG1309	transcriptional regulator
HBM78_RS00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM78_RS00965	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_RS00965	COG0351	phosphomethylpyrimidine kinase
HBM78_RS00975	COG2814	Major facilitator Superfamily
HBM78_RS00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM78_RS01000	COG1113	amino acid transport
HBM78_RS01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM78_RS01015	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS01025	COG1335	isochorismatase
HBM78_RS01055	COG2814	Major facilitator Superfamily
HBM78_RS01060	COG0583	DNA-binding transcription factor activity
HBM78_RS01080	COG0667	Aldo Keto reductase
HBM78_RS01110	COG1733	regulation of RNA biosynthetic process
HBM78_RS01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_RS01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBM78_RS01195	COG2329	Antibiotic biosynthesis monooxygenase
HBM78_RS01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HBM78_RS01255	COG0427	acetyl-CoA hydrolase
HBM78_RS01270	COG0745	RESPONSE REGULATOR receiver
HBM78_RS01280	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_RS01285	COG4221	oxidoreductase activity
HBM78_RS01290	COG2873	o-acetylhomoserine
HBM78_RS01295	COG0488	(ABC) transporter
HBM78_RS01380	COG0833	amino acid
HBM78_RS01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBM78_RS01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBM78_RS01445	COG2226	methyltransferase
HBM78_RS01495	COG0067	glutamate synthase
HBM78_RS01495	COG0069	glutamate synthase activity
HBM78_RS01495	COG0070	glutamate synthase
HBM78_RS01500	COG0493	'glutamate synthase
HBM78_RS01510	COG1704	LemA family
HBM78_RS01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HBM78_RS01535	COG3307	-O-antigen
HBM78_RS01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM78_RS01570	COG0194	GDP metabolic process
HBM78_RS01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HBM78_RS01640	COG5380	lipid catabolic process
HBM78_RS01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBM78_RS01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBM78_RS01675	COG0277	FAD linked oxidase domain protein
HBM78_RS01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HBM78_RS01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_RS01705	COG1289	transmembrane transporter activity
HBM78_RS01715	COG0628	permease
HBM78_RS01720	COG1192	Involved in chromosome partitioning
HBM78_RS01750	COG0833	amino acid
HBM78_RS01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM78_RS01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM78_RS01770	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS01810	COG0583	DNA-binding transcription factor activity
HBM78_RS01855	COG0517	IMP dehydrogenase activity
HBM78_RS01860	COG1983	PspC domain protein
HBM78_RS01870	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS01885	COG0408	coproporphyrinogen oxidase activity
HBM78_RS01905	COG0513	Belongs to the DEAD box helicase family
HBM78_RS01915	COG1127	ABC transporter
HBM78_RS01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBM78_RS01930	COG2854	intermembrane phospholipid transfer
HBM78_RS01940	COG0598	Magnesium transport protein CorA
HBM78_RS01950	COG0494	nUDIX hydrolase
HBM78_RS01955	COG1040	competence protein
HBM78_RS01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBM78_RS01980	COG1946	Acyl-CoA thioesterase
HBM78_RS01985	COG1301	dicarboxylic acid transport
HBM78_RS02000	COG1959	2 iron, 2 sulfur cluster binding
HBM78_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_RS02005	COG1017	nitric oxide dioxygenase activity
HBM78_RS02010	COG0433	COG0433 Predicted ATPase
HBM78_RS02015	COG0626	cystathionine gamma-synthase activity
HBM78_RS02170	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HBM78_RS02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HBM78_RS02210	COG0339	signal peptide processing
HBM78_RS02215	COG0557	exoribonuclease II activity
HBM78_RS02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
HBM78_RS02265	COG2169	Transcriptional regulator
HBM78_RS02270	COG0697	spore germination
HBM78_RS02275	COG1295	ribonuclease BN
HBM78_RS02310	COG1702	phosphate starvation-inducible protein PhoH
HBM78_RS02320	COG1196	nuclear chromosome segregation
HBM78_RS02320	COG0741	lytic transglycosylase activity
HBM78_RS02320	COG0739	heme binding
HBM78_RS02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBM78_RS02355	COG1183	phosphatidylcholine synthase activity
HBM78_RS02400	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS02405	COG1309	transcriptional regulator
HBM78_RS02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM78_RS02425	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS02445	COG2969	positive regulation of protein catabolic process
HBM78_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBM78_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HBM78_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HBM78_RS02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBM78_RS02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM78_RS02510	COG1408	metallophosphoesterase
HBM78_RS02520	COG2199	diguanylate cyclase activity
HBM78_RS02580	COG1607	acyl-coa hydrolase
HBM78_RS02610	COG2350	Protein conserved in bacteria
HBM78_RS02620	COG0613	PHP domain protein
HBM78_RS02625	COG3781	membrane
HBM78_RS02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBM78_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBM78_RS02650	COG1862	Preprotein translocase
HBM78_RS02680	COG2205	protein histidine kinase activity
HBM78_RS02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBM78_RS02705	COG0726	polysaccharide deacetylase
HBM78_RS02710	COG0463	Glycosyl transferase, family 2
HBM78_RS02715	COG0438	transferase activity, transferring glycosyl groups
HBM78_RS02780	COG0625	glutathione transferase activity
HBM78_RS02785	COG0583	DNA-binding transcription factor activity
HBM78_RS02790	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS02795	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS02805	COG2205	protein histidine kinase activity
HBM78_RS02810	COG0745	RESPONSE REGULATOR receiver
HBM78_RS02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HBM78_RS02835	COG2096	Adenosyltransferase
HBM78_RS02885	COG0285	dihydrofolate synthase activity
HBM78_RS02905	COG0450	alkyl hydroperoxide reductase
HBM78_RS02920	COG0477	Major facilitator Superfamily
HBM78_RS02925	COG1272	protein, Hemolysin III
HBM78_RS02960	COG0183	Belongs to the thiolase family
HBM78_RS02965	COG2207	Transcriptional regulator
HBM78_RS02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_RS03005	COG0183	Belongs to the thiolase family
HBM78_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBM78_RS03015	COG2885	chlorophyll binding
HBM78_RS03025	COG1690	Belongs to the RtcB family
HBM78_RS03030	COG0833	amino acid
HBM78_RS03040	COG2233	PERMEase
HBM78_RS03070	COG2094	Belongs to the DNA glycosylase MPG family
HBM78_RS03075	COG4772	TonB-dependent receptor
HBM78_RS03090	COG1902	pentaerythritol trinitrate reductase activity
HBM78_RS03095	COG0679	Auxin Efflux Carrier
HBM78_RS03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_RS03110	COG0354	folic acid binding
HBM78_RS03120	COG3189	MarR family transcriptional regulator
HBM78_RS03125	COG2824	Alkylphosphonate utilization operon protein PhnA
HBM78_RS03130	COG3422	double-strand break repair
HBM78_RS03170	COG0840	transmembrane signaling receptor activity
HBM78_RS03190	COG5510	response to toxic substance
HBM78_RS03200	COG2832	Protein of unknown function (DUF454)
HBM78_RS03205	COG1376	ErfK ybiS ycfS ynhG family protein
HBM78_RS03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HBM78_RS03255	COG1289	transmembrane transporter activity
HBM78_RS03260	COG2814	Major facilitator Superfamily
HBM78_RS03280	COG1115	amino acid carrier protein
HBM78_RS03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM78_RS03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM78_RS03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HBM78_RS03335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM78_RS03345	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBM78_RS03350	COG1077	Cell shape determining protein MreB Mrl
HBM78_RS03355	COG1792	Involved in formation and maintenance of cell shape
HBM78_RS03360	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HBM78_RS03365	COG0424	maF-like protein
HBM78_RS03370	COG1530	ribonuclease E activity
HBM78_RS03380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_RS03390	COG0560	Phosphoserine phosphatase
HBM78_RS03400	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_RS03425	COG2207	Transcriptional regulator
HBM78_RS03445	COG1113	amino acid transport
HBM78_RS03450	COG2828	Protein conserved in bacteria
HBM78_RS03455	COG0142	geranyltranstransferase activity
HBM78_RS03460	COG2315	Protein conserved in bacteria
HBM78_RS03475	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBM78_RS03495	COG2194	sulfuric ester hydrolase activity
HBM78_RS03500	COG0745	RESPONSE REGULATOR receiver
HBM78_RS03505	COG0642	Histidine kinase
HBM78_RS03515	COG0004	ammonium transporteR
HBM78_RS03520	COG0583	DNA-binding transcription factor activity
HBM78_RS03540	COG0525	valine-tRNA ligase activity
HBM78_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS03560	COG0393	Putative heavy-metal-binding
HBM78_RS03565	COG0393	Putative heavy-metal-binding
HBM78_RS03570	COG1538	Outer membrane efflux protein
HBM78_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS03585	COG0671	phosphoesterase, PA-phosphatase related
HBM78_RS03615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HBM78_RS03630	COG1648	precorrin-2 dehydrogenase activity
HBM78_RS03630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBM78_RS03635	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBM78_RS03640	COG1733	regulation of RNA biosynthetic process
HBM78_RS03650	COG0531	amino acid
HBM78_RS03665	COG0321	lipoyl(octanoyl) transferase activity
HBM78_RS03670	COG2921	Belongs to the UPF0250 family
HBM78_RS03710	COG2009	succinate dehydrogenase
HBM78_RS03715	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HBM78_RS03720	COG1053	succinate dehydrogenase
HBM78_RS03725	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBM78_RS03750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_RS03770	COG2354	Protein conserved in bacteria
HBM78_RS03775	COG2321	neutral zinc metallopeptidase
HBM78_RS03810	COG2843	Capsule synthesis protein
HBM78_RS03825	COG0589	response to stress
HBM78_RS03845	COG0505	Belongs to the CarA family
HBM78_RS03870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM78_RS03875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBM78_RS03925	COG0477	Major facilitator Superfamily
HBM78_RS03930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBM78_RS03945	COG1597	lipid kinase activity
HBM78_RS03950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM78_RS03980	COG0584	glycerophosphoryl diester phosphodiesterase
HBM78_RS04000	COG0741	lytic transglycosylase activity
HBM78_RS04020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HBM78_RS04035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_RS04060	COG0778	Nitroreductase
HBM78_RS04075	COG1929	Belongs to the glycerate kinase type-1 family
HBM78_RS04080	COG0243	molybdopterin cofactor binding
HBM78_RS04085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HBM78_RS04090	COG3339	Conserved Protein
HBM78_RS04100	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HBM78_RS04115	COG1113	amino acid transport
HBM78_RS04125	COG0019	diaminopimelate decarboxylase activity
HBM78_RS04135	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS04140	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBM78_RS04170	COG0463	Glycosyl transferase, family 2
HBM78_RS04190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS04225	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBM78_RS04230	COG1136	(ABC) transporter
HBM78_RS04235	COG2333	competence protein COMEC
HBM78_RS04235	COG0658	competence protein
HBM78_RS04245	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBM78_RS04245	COG0616	signal peptide processing
HBM78_RS04250	COG0596	Alpha beta hydrolase
HBM78_RS04255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBM78_RS04265	COG0628	permease
HBM78_RS04300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM78_RS04320	COG0823	Involved in the tonB-independent uptake of proteins
HBM78_RS04340	COG0824	Thioesterase
HBM78_RS04345	COG1473	amidohydrolase
HBM78_RS04365	COG0047	phosphoribosylformylglycinamidine synthase activity
HBM78_RS04365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBM78_RS04370	COG2814	Major facilitator Superfamily
HBM78_RS04380	COG1024	Enoyl-CoA hydratase
HBM78_RS04385	COG1056	cytidyltransferase-related domain
HBM78_RS04385	COG1051	belongs to the nudix hydrolase family
HBM78_RS04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBM78_RS04410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBM78_RS04425	COG4625	pathogenesis
HBM78_RS04430	COG0583	DNA-binding transcription factor activity
HBM78_RS04435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HBM78_RS04440	COG4208	sulfate ABC transporter
HBM78_RS04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HBM78_RS04455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HBM78_RS04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBM78_RS04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBM78_RS04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM78_RS04500	COG0681	Belongs to the peptidase S26 family
HBM78_RS04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HBM78_RS04525	COG1381	Involved in DNA repair and RecF pathway recombination
HBM78_RS04530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HBM78_RS04540	COG4221	oxidoreductase activity
HBM78_RS04570	COG0436	Aminotransferase
HBM78_RS04590	COG0556	nucleotide-excision repair
HBM78_RS04645	COG2070	2-Nitropropane dioxygenase
HBM78_RS04675	COG1215	transferase activity, transferring glycosyl groups
HBM78_RS04690	COG0415	Belongs to the DNA photolyase family
HBM78_RS04700	COG1252	NADH dehydrogenase
HBM78_RS04705	COG1686	Belongs to the peptidase S11 family
HBM78_RS04720	COG1187	pseudouridine synthase activity
HBM78_RS04745	COG0477	Major facilitator Superfamily
HBM78_RS04750	COG0583	DNA-binding transcription factor activity
HBM78_RS04765	COG0612	Peptidase, M16
HBM78_RS04790	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_RS04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_RS04840	COG1309	transcriptional regulator
HBM78_RS04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBM78_RS04855	COG0076	glutamate decarboxylase activity
HBM78_RS04865	COG1522	sequence-specific DNA binding
HBM78_RS04870	COG3961	Belongs to the TPP enzyme family
HBM78_RS04875	COG1113	amino acid transport
HBM78_RS04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HBM78_RS04885	COG0573	inorganic phosphate transmembrane transporter activity
HBM78_RS04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBM78_RS04900	COG0616	signal peptide processing
HBM78_RS04910	COG3328	transposase activity
HBM78_RS04940	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBM78_RS04945	COG1686	Belongs to the peptidase S11 family
HBM78_RS04970	COG0583	DNA-binding transcription factor activity
HBM78_RS04975	COG1067	ATP-dependent peptidase activity
HBM78_RS05020	COG1966	Carbon starvation protein
HBM78_RS05025	COG2879	small protein
HBM78_RS05060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HBM78_RS05060	COG2508	Transcriptional regulator
HBM78_RS05080	COG1113	amino acid transport
HBM78_RS05085	COG0583	DNA-binding transcription factor activity
HBM78_RS05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_RS05095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_RS05105	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS05110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_RS05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HBM78_RS05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM78_RS05150	COG2814	Major facilitator Superfamily
HBM78_RS05155	COG4948	Mandelate Racemase Muconate Lactonizing
HBM78_RS05165	COG1309	transcriptional regulator
HBM78_RS05185	COG1741	Belongs to the pirin family
HBM78_RS05195	COG2964	Protein conserved in bacteria
HBM78_RS05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_RS05215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBM78_RS05220	COG4605	iron ion homeostasis
HBM78_RS05225	COG4604	ABC transporter, ATP-binding protein
HBM78_RS05230	COG4607	ABC-type enterochelin transport system periplasmic component
HBM78_RS05235	COG4774	siderophore transport
HBM78_RS05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBM78_RS05250	COG1021	2,3-dihydroxybenzoate-AMP ligase
HBM78_RS05255	COG1535	isochorismatase
HBM78_RS05255	COG3433	isochorismatase activity
HBM78_RS05270	COG1132	(ABC) transporter
HBM78_RS05280	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HBM78_RS05290	COG1169	isochorismate synthase
HBM78_RS05305	COG3739	integral membrane protein
HBM78_RS05340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HBM78_RS05370	COG0308	aminopeptidase N
HBM78_RS05375	COG0512	Glutamine amidotransferase of anthranilate synthase
HBM78_RS05545	COG5410	chromosome segregation
HBM78_RS05745	COG0582	viral genome integration into host DNA
HBM78_RS05755	COG3104	oligopeptide transport
HBM78_RS05760	COG0174	glutamine synthetase
HBM78_RS05770	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBM78_RS05805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBM78_RS05810	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBM78_RS05815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBM78_RS05835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBM78_RS05840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBM78_RS05845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBM78_RS05860	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS05865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM78_RS05870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_RS05880	COG2223	nitrite transmembrane transporter activity
HBM78_RS05890	COG0024	Methionine aminopeptidase
HBM78_RS05895	COG0052	Belongs to the universal ribosomal protein uS2 family
HBM78_RS05910	COG2207	Transcriptional regulator
HBM78_RS05935	COG2951	lytic endotransglycosylase activity
HBM78_RS05940	COG0772	Belongs to the SEDS family
HBM78_RS05955	COG0842	Transport permease protein
HBM78_RS05960	COG1131	(ABC) transporter
HBM78_RS06005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS06020	COG4215	(ABC) transporter
HBM78_RS06025	COG4160	amino acid transport
HBM78_RS06030	COG4598	ABC transporter
HBM78_RS06040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM78_RS06050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_RS06065	COG1720	tRNA m6t6A37 methyltransferase activity
HBM78_RS06085	COG0745	RESPONSE REGULATOR receiver
HBM78_RS06090	COG0642	Histidine kinase
HBM78_RS06100	COG0494	nUDIX hydrolase
HBM78_RS06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HBM78_RS06115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HBM78_RS06120	COG3139	Protein of unknown function (DUF1315)
HBM78_RS06125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBM78_RS06130	COG1301	dicarboxylic acid transport
HBM78_RS06135	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS06140	COG2819	hydrolase of the alpha beta superfamily
HBM78_RS06150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HBM78_RS06160	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBM78_RS06165	COG1234	tRNA 3'-trailer cleavage
HBM78_RS06195	COG2363	Small membrane protein
HBM78_RS06215	COG0513	Belongs to the DEAD box helicase family
HBM78_RS06225	COG0778	Nitroreductase
HBM78_RS06255	COG1286	toxin biosynthetic process
HBM78_RS06280	COG4783	chaperone-mediated protein folding
HBM78_RS06285	COG1610	YqeY-like protein
HBM78_RS06385	COG3111	PFAM Bacterial OB fold (BOF) protein
HBM78_RS06410	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBM78_RS06415	COG0786	glutamate:sodium symporter activity
HBM78_RS06425	COG2186	Transcriptional regulator
HBM78_RS06475	COG0477	Major facilitator Superfamily
HBM78_RS06500	COG2985	domain, Protein
HBM78_RS06510	COG2995	paraquat-inducible protein a
HBM78_RS06515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBM78_RS06515	COG3008	intermembrane lipid transfer
HBM78_RS06535	COG0482	sulfurtransferase activity
HBM78_RS06555	COG3173	Aminoglycoside phosphotransferase
HBM78_RS06565	COG2433	Pfam Transposase IS66
HBM78_RS06605	COG1301	dicarboxylic acid transport
HBM78_RS06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_RS06620	COG2011	ABC-type metal ion transport system permease component
HBM78_RS06625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM78_RS06630	COG1464	Belongs to the NlpA lipoprotein family
HBM78_RS06635	COG0151	Belongs to the GarS family
HBM78_RS06640	COG0138	bifunctional purine biosynthesis protein purh
HBM78_RS06645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBM78_RS06675	COG2308	Evidence 4 Homologs of previously reported genes of
HBM78_RS06685	COG1305	Transglutaminase-like
HBM78_RS06695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HBM78_RS06700	COG0305	Participates in initiation and elongation during chromosome replication
HBM78_RS06725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HBM78_RS06735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBM78_RS06740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBM78_RS06765	COG0726	polysaccharide deacetylase
HBM78_RS06765	COG1649	PFAM Uncharacterised BCR, COG1649
HBM78_RS06770	COG1215	transferase activity, transferring glycosyl groups
HBM78_RS06775	COG3658	cytochrome
HBM78_RS06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_RS06800	COG0583	DNA-binding transcription factor activity
HBM78_RS06820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_RS06825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_RS06840	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_RS06850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_RS06875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HBM78_RS06880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HBM78_RS06890	COG2205	protein histidine kinase activity
HBM78_RS06895	COG0745	RESPONSE REGULATOR receiver
HBM78_RS06900	COG0174	glutamine synthetase
HBM78_RS06920	COG0729	surface antigen
HBM78_RS06945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM78_RS06950	COG2814	Major facilitator Superfamily
HBM78_RS06965	COG0583	DNA-binding transcription factor activity
HBM78_RS06980	COG1187	pseudouridine synthase activity
HBM78_RS07000	COG0802	atpase or kinase
HBM78_RS07005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBM78_RS07015	COG1923	regulation of RNA biosynthetic process
HBM78_RS07020	COG0697	spore germination
HBM78_RS07035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_RS07045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM78_RS07050	COG0519	Catalyzes the synthesis of GMP from XMP
HBM78_RS07050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM78_RS07055	COG4302	ethanolamine ammonia-lyase activity
HBM78_RS07060	COG4303	Ethanolamine ammonia lyase large subunit
HBM78_RS07065	COG0531	amino acid
HBM78_RS07085	COG1454	alcohol dehydrogenase
HBM78_RS07090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM78_RS07100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HBM78_RS07120	COG0308	aminopeptidase N
HBM78_RS07150	COG1605	Chorismate mutase
HBM78_RS07165	COG1309	transcriptional regulator
HBM78_RS07175	COG0668	transmembrane transport
HBM78_RS07210	COG4773	Receptor
HBM78_RS07245	COG3135	benzoate transporter
HBM78_RS07250	COG1522	sequence-specific DNA binding
HBM78_RS07260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HBM78_RS07265	COG0583	DNA-binding transcription factor activity
HBM78_RS07275	COG0183	Belongs to the thiolase family
HBM78_RS07285	COG2030	dehydratase
HBM78_RS07305	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBM78_RS07315	COG0824	Thioesterase
HBM78_RS07320	COG1454	alcohol dehydrogenase
HBM78_RS07330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBM78_RS07515	COG5410	chromosome segregation
HBM78_RS07635	COG0739	heme binding
HBM78_RS07700	COG2814	Major facilitator Superfamily
HBM78_RS07715	COG0511	ligase activity, forming carbon-carbon bonds
HBM78_RS07735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_RS07735	COG1116	anion transmembrane transporter activity
HBM78_RS07740	COG0745	RESPONSE REGULATOR receiver
HBM78_RS07750	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_RS07750	COG2146	nitrite reductase [NAD(P)H] activity
HBM78_RS07755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_RS07760	COG0243	molybdopterin cofactor binding
HBM78_RS07770	COG0243	molybdopterin cofactor binding
HBM78_RS07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HBM78_RS07790	COG0315	cyclic pyranopterin monophosphate synthase activity
HBM78_RS07790	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBM78_RS07795	COG0303	'Molybdopterin
HBM78_RS07805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_RS07810	COG0697	spore germination
HBM78_RS07830	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HBM78_RS07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM78_RS07890	COG2204	response regulator
HBM78_RS07895	COG3852	Histidine kinase
HBM78_RS07915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBM78_RS07920	COG0575	Belongs to the CDS family
HBM78_RS07955	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_RS07970	COG2137	regulation of response to DNA damage stimulus
HBM78_RS07980	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBM78_RS07985	COG1011	Hydrolase
HBM78_RS08010	COG1522	sequence-specific DNA binding
HBM78_RS08020	COG1113	amino acid transport
HBM78_RS08035	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_RS08040	COG2135	peptidase activity
HBM78_RS08055	COG5001	Diguanylate cyclase
HBM78_RS08055	COG3300	MHYT domain
HBM78_RS08075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM78_RS08075	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HBM78_RS08075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBM78_RS08080	COG1105	Belongs to the carbohydrate kinase PfkB family
HBM78_RS08085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM78_RS08085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBM78_RS08115	COG0024	Methionine aminopeptidase
HBM78_RS08120	COG0583	DNA-binding transcription factor activity
HBM78_RS08130	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBM78_RS08135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBM78_RS08140	COG0517	IMP dehydrogenase activity
HBM78_RS08140	COG0516	GMP reductase activity
HBM78_RS08165	COG0552	protein localization to endoplasmic reticulum
HBM78_RS08175	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HBM78_RS08190	COG4890	Cyd operon protein YbgT
HBM78_RS08195	COG1294	oxidase, subunit
HBM78_RS08210	COG1585	Membrane protein implicated in regulation of membrane protease activity
HBM78_RS08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBM78_RS08225	COG4774	siderophore transport
HBM78_RS08240	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBM78_RS08245	COG0569	domain protein
HBM78_RS08250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBM78_RS08280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HBM78_RS08285	COG0542	response to heat
HBM78_RS08310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_RS08310	COG1902	pentaerythritol trinitrate reductase activity
HBM78_RS08355	COG2323	membrane
HBM78_RS08360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HBM78_RS08370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_RS08375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_RS08380	COG0183	Belongs to the thiolase family
HBM78_RS08385	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HBM78_RS08390	COG0596	Alpha beta hydrolase
HBM78_RS08395	COG2271	Major facilitator Superfamily
HBM78_RS08400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM78_RS08405	COG3485	protocatechuate 3,4-dioxygenase
HBM78_RS08410	COG3485	protocatechuate 3,4-dioxygenase
HBM78_RS08415	COG0710	3-dehydroquinate dehydratase activity
HBM78_RS08420	COG3420	alginic acid biosynthetic process
HBM78_RS08425	COG3659	wide pore channel activity
HBM78_RS08430	COG4993	Dehydrogenase
HBM78_RS08440	COG2391	methyltransferase activity
HBM78_RS08455	COG1414	Transcriptional regulator
HBM78_RS08460	COG0583	DNA-binding transcription factor activity
HBM78_RS08465	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS08490	COG2814	Major facilitator Superfamily
HBM78_RS08500	COG0154	amidase activity
HBM78_RS08520	COG4638	Rieske (2fe-2S)
HBM78_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS08540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_RS08550	COG3733	amine oxidase
HBM78_RS08560	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS08570	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_RS08575	COG0183	Belongs to the thiolase family
HBM78_RS08580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_RS08585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_RS08595	COG4829	muconolactone delta-isomerase
HBM78_RS08600	COG4948	Mandelate Racemase Muconate Lactonizing
HBM78_RS08605	COG0583	DNA-binding transcription factor activity
HBM78_RS08615	COG2186	Transcriptional regulator
HBM78_RS08635	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS08655	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS08665	COG3829	transcription factor binding
HBM78_RS08675	COG3162	membrane
HBM78_RS08690	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS08705	COG0753	catalase activity
HBM78_RS08725	COG1846	Transcriptional regulator
HBM78_RS08730	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_RS08730	COG1902	pentaerythritol trinitrate reductase activity
HBM78_RS08740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBM78_RS08770	COG1309	transcriptional regulator
HBM78_RS08780	COG1335	isochorismatase
HBM78_RS08785	COG0583	DNA-binding transcription factor activity
HBM78_RS08795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_RS08795	COG0475	glutathione-regulated potassium exporter activity
HBM78_RS08805	COG1473	amidohydrolase
HBM78_RS08815	COG2831	hemolysin activation secretion protein
HBM78_RS08860	COG2188	Transcriptional regulator
HBM78_RS08875	COG0583	DNA-binding transcription factor activity
HBM78_RS08905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM78_RS08925	COG1566	PFAM secretion protein HlyD family protein
HBM78_RS08940	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS08945	COG0129	dihydroxy-acid dehydratase activity
HBM78_RS08955	COG0583	DNA-binding transcription factor activity
HBM78_RS08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBM78_RS08970	COG2084	Dehydrogenase
HBM78_RS08975	COG2207	Transcriptional regulator
HBM78_RS08990	COG1064	alcohol dehydrogenase
HBM78_RS09005	COG1120	ATPase activity
HBM78_RS09025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM78_RS09140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HBM78_RS09190	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS09205	COG2207	Transcriptional regulator
HBM78_RS09215	COG2205	protein histidine kinase activity
HBM78_RS09220	COG0745	RESPONSE REGULATOR receiver
HBM78_RS09225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS09230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM78_RS09235	COG1538	Outer membrane efflux protein
HBM78_RS09245	COG2072	flavoprotein involved in K transport
HBM78_RS09265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBM78_RS09285	COG3539	Fimbrial protein
HBM78_RS09315	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HBM78_RS09325	COG0753	catalase activity
HBM78_RS09340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBM78_RS09405	COG3433	isochorismatase activity
HBM78_RS09405	COG1535	isochorismatase
HBM78_RS09410	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS09415	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HBM78_RS09420	COG4149	molybdate abc transporter
HBM78_RS09425	COG0725	ABC transporter, periplasmic molybdate-binding protein
HBM78_RS09435	COG4638	Rieske (2fe-2S)
HBM78_RS09440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM78_RS09445	COG0543	2 iron, 2 sulfur cluster binding
HBM78_RS09445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBM78_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS09485	COG2207	Transcriptional regulator
HBM78_RS09495	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS09500	COG2610	gluconate transmembrane transporter activity
HBM78_RS09510	COG0583	DNA-binding transcription factor activity
HBM78_RS09520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_RS09525	COG2031	fatty acid transporter
HBM78_RS09530	COG0183	Belongs to the thiolase family
HBM78_RS09535	COG0583	DNA-binding transcription factor activity
HBM78_RS09540	COG0583	DNA-binding transcription factor activity
HBM78_RS09555	COG1027	Aspartate ammonia-lyase
HBM78_RS09565	COG0477	Major facilitator Superfamily
HBM78_RS09585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_RS09590	COG4521	taurine ABC transporter
HBM78_RS09605	COG2188	Transcriptional regulator
HBM78_RS09615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HBM78_RS09620	COG1733	regulation of RNA biosynthetic process
HBM78_RS09625	COG2207	Transcriptional regulator
HBM78_RS09625	COG3708	Transcriptional regulator
HBM78_RS09640	COG0730	response to heat
HBM78_RS09650	COG3453	Protein conserved in bacteria
HBM78_RS09650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_RS09660	COG3781	membrane
HBM78_RS09665	COG1063	alcohol dehydrogenase
HBM78_RS09675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBM78_RS09680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBM78_RS09685	COG0022	dehydrogenase e1 component
HBM78_RS09690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HBM78_RS09695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBM78_RS09710	COG3706	GGDEF domain
HBM78_RS09725	COG0133	tryptophan synthase activity
HBM78_RS09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBM78_RS09770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HBM78_RS09795	COG2226	methyltransferase
HBM78_RS09850	COG0842	Transport permease protein
HBM78_RS09855	COG0842	Transport permease protein
HBM78_RS09860	COG1131	(ABC) transporter
HBM78_RS09875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBM78_RS09880	COG4773	Receptor
HBM78_RS09900	COG0730	response to heat
HBM78_RS09905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBM78_RS09925	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HBM78_RS09980	COG4264	IucA IucC family
HBM78_RS09985	COG4264	IucA IucC family
HBM78_RS10005	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBM78_RS10020	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS10025	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS10030	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBM78_RS10035	COG2207	Transcriptional regulator
HBM78_RS10040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM78_RS10045	COG0776	regulation of translation
HBM78_RS10070	COG0822	iron-sulfur transferase activity
HBM78_RS10075	COG0316	Belongs to the HesB IscA family
HBM78_RS10105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBM78_RS10125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBM78_RS10130	COG0702	epimerase
HBM78_RS10165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBM78_RS10175	COG0339	signal peptide processing
HBM78_RS10225	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HBM78_RS10230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBM78_RS10260	COG0776	regulation of translation
HBM78_RS10325	COG0084	hydrolase, TatD family'
HBM78_RS10345	COG1663	tetraacyldisaccharide 4'-kinase activity
HBM78_RS10350	COG1132	(ABC) transporter
HBM78_RS10360	COG0811	peptide transport
HBM78_RS10365	COG1475	DNA binding
HBM78_RS10370	COG1192	Involved in chromosome partitioning
HBM78_RS10380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBM78_RS10395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBM78_RS10400	COG0191	fructose-bisphosphate aldolase activity
HBM78_RS10420	COG0424	maF-like protein
HBM78_RS10425	COG2850	peptidyl-arginine hydroxylation
HBM78_RS10435	COG0640	Transcriptional regulator
HBM78_RS10445	COG3619	membrane
HBM78_RS10450	COG3122	Protein conserved in bacteria
HBM78_RS10455	COG1132	(ABC) transporter
HBM78_RS10475	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HBM78_RS10480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBM78_RS10490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM78_RS10490	COG0506	proline dehydrogenase activity
HBM78_RS10490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBM78_RS10495	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBM78_RS10510	COG3698	Phosphodiester glycosidase
HBM78_RS10520	COG2353	YceI-like domain
HBM78_RS10530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HBM78_RS10575	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBM78_RS10575	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBM78_RS10600	COG3539	Fimbrial protein
HBM78_RS10605	COG3121	Chaperone
HBM78_RS10635	COG0697	spore germination
HBM78_RS10645	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM78_RS10655	COG0583	DNA-binding transcription factor activity
HBM78_RS10675	COG1309	transcriptional regulator
HBM78_RS10690	COG1522	sequence-specific DNA binding
HBM78_RS10700	COG1126	abc transporter atp-binding protein
HBM78_RS10705	COG0765	amino acid transport
HBM78_RS10710	COG0765	amino acid transport
HBM78_RS10740	COG1464	Belongs to the NlpA lipoprotein family
HBM78_RS10750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBM78_RS10755	COG2011	ABC-type metal ion transport system permease component
HBM78_RS10760	COG0012	GTP binding
HBM78_RS10785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBM78_RS10825	COG0386	Belongs to the glutathione peroxidase family
HBM78_RS10835	COG0436	Aminotransferase
HBM78_RS10875	COG3634	alkyl hydroperoxide reductase activity
HBM78_RS10890	COG0583	DNA-binding transcription factor activity
HBM78_RS10895	COG0798	PFAM Bile acid sodium symporter
HBM78_RS10900	COG0640	Transcriptional regulator
HBM78_RS10915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HBM78_RS10925	COG0583	DNA-binding transcription factor activity
HBM78_RS10935	COG1953	Uracil, thiamine, allantoin
HBM78_RS10945	COG2175	clavaminate synthase activity
HBM78_RS10950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_RS10955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HBM78_RS10960	COG4521	taurine ABC transporter
HBM78_RS10970	COG0477	Major facilitator Superfamily
HBM78_RS10990	COG1271	oxidase subunit
HBM78_RS10995	COG1294	oxidase, subunit
HBM78_RS11005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBM78_RS11025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBM78_RS11045	COG3052	prosthetic group binding
HBM78_RS11050	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HBM78_RS11060	COG2814	Major facilitator Superfamily
HBM78_RS11080	COG1346	cytolysis
HBM78_RS11090	COG0583	DNA-binding transcription factor activity
HBM78_RS11095	COG0625	glutathione transferase activity
HBM78_RS11100	COG0625	glutathione transferase activity
HBM78_RS11105	COG0583	DNA-binding transcription factor activity
HBM78_RS11120	COG1045	serine acetyltransferase
HBM78_RS11125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBM78_RS11130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBM78_RS11140	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS11160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_RS11165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_RS11170	COG1126	abc transporter atp-binding protein
HBM78_RS11175	COG0765	amino acid transport
HBM78_RS11180	COG0765	amino acid transport
HBM78_RS11200	COG2205	protein histidine kinase activity
HBM78_RS11200	COG0784	Response regulator, receiver
HBM78_RS11220	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBM78_RS11240	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS11290	COG0583	DNA-binding transcription factor activity
HBM78_RS11310	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_RS11315	COG1309	transcriptional regulator
HBM78_RS11320	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS11325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBM78_RS11330	COG1024	Enoyl-CoA hydratase
HBM78_RS11335	COG4770	biotin carboxylase activity
HBM78_RS11345	COG0583	DNA-binding transcription factor activity
HBM78_RS11360	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS11370	COG2814	Major facilitator Superfamily
HBM78_RS11380	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBM78_RS11385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBM78_RS11390	COG2814	Major facilitator Superfamily
HBM78_RS11395	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS11400	COG1024	Enoyl-CoA hydratase
HBM78_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM78_RS11415	COG0183	Belongs to the thiolase family
HBM78_RS11425	COG2814	Major facilitator Superfamily
HBM78_RS11435	COG1024	Enoyl-CoA hydratase
HBM78_RS11450	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS11455	COG2814	Major facilitator Superfamily
HBM78_RS11460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBM78_RS11465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HBM78_RS11480	COG3842	ATPase activity
HBM78_RS11485	COG1840	ABC-type Fe3 transport system, periplasmic component
HBM78_RS11495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_RS11500	COG1414	Transcriptional regulator
HBM78_RS11510	COG0583	DNA-binding transcription factor activity
HBM78_RS11515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBM78_RS11520	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS11530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBM78_RS11540	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS11545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_RS11550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_RS11555	COG2267	carboxylic ester hydrolase activity
HBM78_RS11575	COG3038	cytochrome b561
HBM78_RS11580	COG0753	catalase activity
HBM78_RS11615	COG2050	protein possibly involved in aromatic compounds catabolism
HBM78_RS11640	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBM78_RS11655	COG2807	transmembrane transport
HBM78_RS11660	COG0590	tRNA wobble adenosine to inosine editing
HBM78_RS11775	COG1116	anion transmembrane transporter activity
HBM78_RS11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBM78_RS11790	COG0864	Transcriptional regulator
HBM78_RS11810	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBM78_RS11815	COG0439	Biotin carboxylase
HBM78_RS11830	COG1063	alcohol dehydrogenase
HBM78_RS11840	COG1309	transcriptional regulator
HBM78_RS11860	COG0038	chloride channel
HBM78_RS11865	COG4770	biotin carboxylase activity
HBM78_RS11885	COG1914	H( )-stimulated, divalent metal cation uptake system
HBM78_RS11890	COG0583	DNA-binding transcription factor activity
HBM78_RS11905	COG3209	COG3209 Rhs family protein
HBM78_RS11910	COG3501	Rhs element vgr protein
HBM78_RS11940	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBM78_RS11960	COG2814	Major facilitator Superfamily
HBM78_RS11970	COG1560	Kdo2-lipid A biosynthetic process
HBM78_RS11980	COG5006	permease, DMT superfamily
HBM78_RS11985	COG1522	sequence-specific DNA binding
HBM78_RS12000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HBM78_RS12010	COG4122	O-methyltransferase activity
HBM78_RS12040	COG1538	Outer membrane efflux protein
HBM78_RS12050	COG1137	ATPase activity
HBM78_RS12055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBM78_RS12065	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBM78_RS12070	COG0517	IMP dehydrogenase activity
HBM78_RS12070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HBM78_RS12110	COG2814	Major facilitator Superfamily
HBM78_RS12145	COG1278	Cold shock
HBM78_RS12150	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS12185	COG1570	exodeoxyribonuclease VII activity
HBM78_RS12235	COG0583	DNA-binding transcription factor activity
HBM78_RS12240	COG4638	Rieske (2fe-2S)
HBM78_RS12245	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBM78_RS12250	COG0633	Ferredoxin
HBM78_RS12250	COG0543	2 iron, 2 sulfur cluster binding
HBM78_RS12255	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS12260	COG3135	benzoate transporter
HBM78_RS12265	COG2814	Major facilitator Superfamily
HBM78_RS12280	COG1643	Atp-dependent helicase
HBM78_RS12285	COG0450	alkyl hydroperoxide reductase
HBM78_RS12295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBM78_RS12305	COG3634	alkyl hydroperoxide reductase activity
HBM78_RS12325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HBM78_RS12330	COG0625	glutathione transferase activity
HBM78_RS12340	COG2885	chlorophyll binding
HBM78_RS12375	COG0542	response to heat
HBM78_RS12390	COG1765	OsmC-like protein
HBM78_RS12405	COG0667	Aldo Keto reductase
HBM78_RS12420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBM78_RS12430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBM78_RS12440	COG0527	aspartate kinase activity
HBM78_RS12450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBM78_RS12460	COG3038	cytochrome b561
HBM78_RS12465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HBM78_RS12470	COG2252	PERMEase
HBM78_RS12480	COG2072	flavoprotein involved in K transport
HBM78_RS12495	COG1741	Belongs to the pirin family
HBM78_RS12500	COG1309	transcriptional regulator
HBM78_RS12525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HBM78_RS12565	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_RS12565	COG1902	pentaerythritol trinitrate reductase activity
HBM78_RS12575	COG2203	Gaf domain
HBM78_RS12575	COG4251	negative regulation of phosphorylation
HBM78_RS12575	COG5001	Diguanylate cyclase
HBM78_RS12575	COG3706	GGDEF domain
HBM78_RS12585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM78_RS12605	COG4172	Belongs to the ABC transporter superfamily
HBM78_RS12610	COG4239	(ABC) transporter, permease
HBM78_RS12615	COG4174	ABC transporter (Permease)
HBM78_RS12625	COG1388	LysM domain
HBM78_RS12625	COG0741	lytic transglycosylase activity
HBM78_RS12625	COG1388	LysM domain
HBM78_RS12625	COG0741	lytic transglycosylase activity
HBM78_RS12630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBM78_RS12670	COG0583	DNA-binding transcription factor activity
HBM78_RS12675	COG1279	arginine transmembrane transporter activity
HBM78_RS12695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_RS12700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_RS12705	COG0006	proline dipeptidase activity
HBM78_RS12740	COG2194	sulfuric ester hydrolase activity
HBM78_RS12785	COG0739	heme binding
HBM78_RS13215	COG4695	Portal protein
HBM78_RS13310	COG0305	Participates in initiation and elongation during chromosome replication
HBM78_RS13325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBM78_RS13380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBM78_RS13405	COG3384	dioxygenase
HBM78_RS13415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBM78_RS13420	COG2878	Part of a membrane complex involved in electron transport
HBM78_RS13425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBM78_RS13450	COG0768	penicillin binding
HBM78_RS13455	COG0742	ribosomal rna small subunit methyltransferase
HBM78_RS13470	COG0830	nickel cation binding
HBM78_RS13480	COG0804	urea catabolic process
HBM78_RS13520	COG1253	flavin adenine dinucleotide binding
HBM78_RS13525	COG2851	Citrate transporter
HBM78_RS13580	COG1773	rubredoxin
HBM78_RS13585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBM78_RS13595	COG0583	DNA-binding transcription factor activity
HBM78_RS13620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HBM78_RS13625	COG4181	ATPase activity
HBM78_RS13670	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBM78_RS13690	COG0306	phosphate transporter
HBM78_RS13700	COG3958	Transketolase
HBM78_RS13705	COG3959	Transketolase, thiamine diphosphate binding domain
HBM78_RS13710	COG2271	Major facilitator Superfamily
HBM78_RS13715	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS13720	COG0583	DNA-binding transcription factor activity
HBM78_RS13735	COG2223	nitrite transmembrane transporter activity
HBM78_RS13740	COG2207	Transcriptional regulator
HBM78_RS13745	COG2066	Belongs to the glutaminase family
HBM78_RS13750	COG0242	peptide deformylase activity
HBM78_RS13755	COG0477	Major facilitator Superfamily
HBM78_RS13765	COG0028	Belongs to the TPP enzyme family
HBM78_RS13780	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS13785	COG2267	carboxylic ester hydrolase activity
HBM78_RS13795	COG2271	Major facilitator Superfamily
HBM78_RS13800	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBM78_RS13810	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS13830	COG1414	Transcriptional regulator
HBM78_RS13845	COG1024	Enoyl-CoA hydratase
HBM78_RS13855	COG1215	transferase activity, transferring glycosyl groups
HBM78_RS13860	COG0726	polysaccharide deacetylase
HBM78_RS13860	COG1649	PFAM Uncharacterised BCR, COG1649
HBM78_RS13870	COG4681	YaeQ
HBM78_RS13880	COG0523	cobalamin synthesis protein
HBM78_RS13890	COG1607	acyl-coa hydrolase
HBM78_RS13900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_RS13905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBM78_RS13910	COG1309	transcriptional regulator
HBM78_RS13935	COG2040	homocysteine
HBM78_RS13940	COG0531	amino acid
HBM78_RS13995	COG1595	DNA-templated transcription, initiation
HBM78_RS14005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_RS14010	COG0477	Major facilitator Superfamily
HBM78_RS14030	COG0084	hydrolase, TatD family'
HBM78_RS14065	COG0629	single-stranded DNA binding
HBM78_RS14120	COG0582	viral genome integration into host DNA
HBM78_RS14130	COG0405	Gamma-glutamyltransferase
HBM78_RS14135	COG2814	Major facilitator Superfamily
HBM78_RS14145	COG2050	protein possibly involved in aromatic compounds catabolism
HBM78_RS14160	COG1090	epimerase
HBM78_RS14180	COG0420	3'-5' exonuclease activity
HBM78_RS14205	COG0735	belongs to the Fur family
HBM78_RS14210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBM78_RS14230	COG0121	glutamine amidotransferase
HBM78_RS14245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_RS14255	COG0210	DNA helicase
HBM78_RS14260	COG2885	chlorophyll binding
HBM78_RS14265	COG0204	Acyl-transferase
HBM78_RS14280	COG2894	cell division
HBM78_RS14300	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS14305	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBM78_RS14305	COG1674	ftsk spoiiie
HBM78_RS14310	COG0492	ferredoxin-NADP+ reductase activity
HBM78_RS14315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HBM78_RS14325	COG0456	acetyltransferase
HBM78_RS14385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBM78_RS14385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM78_RS14405	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS14425	COG0473	3-isopropylmalate dehydrogenase activity
HBM78_RS14430	COG0583	DNA-binding transcription factor activity
HBM78_RS14450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBM78_RS14475	COG0564	pseudouridine synthase activity
HBM78_RS14485	COG0358	DNA primase activity
HBM78_RS14500	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HBM78_RS14530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBM78_RS14560	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBM78_RS14570	COG0351	phosphomethylpyrimidine kinase
HBM78_RS14570	COG0352	thiamine-phosphate diphosphorylase activity
HBM78_RS14570	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBM78_RS14575	COG1652	LysM domain
HBM78_RS14600	COG1399	metal-binding, possibly nucleic acid-binding protein
HBM78_RS14605	COG3101	peptidyl-lysine hydroxylation
HBM78_RS14610	COG0009	L-threonylcarbamoyladenylate synthase
HBM78_RS14615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HBM78_RS14620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBM78_RS14635	COG4106	trans-aconitate 2-methyltransferase activity
HBM78_RS14650	COG2226	methyltransferase
HBM78_RS14650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_RS14650	COG0596	Alpha beta hydrolase
HBM78_RS14655	COG1877	trehalose-phosphatase activity
HBM78_RS14660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HBM78_RS14665	COG2223	nitrite transmembrane transporter activity
HBM78_RS14685	COG1196	nuclear chromosome segregation
HBM78_RS14695	COG0730	response to heat
HBM78_RS14710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBM78_RS14720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM78_RS14770	COG0489	protein tyrosine kinase activity
HBM78_RS14780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_RS14780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_RS14810	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HBM78_RS14815	COG2081	HI0933 family
HBM78_RS14825	COG0668	transmembrane transport
HBM78_RS14845	COG0583	DNA-binding transcription factor activity
HBM78_RS14865	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBM78_RS14870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM78_RS14900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HBM78_RS14935	COG2205	protein histidine kinase activity
HBM78_RS14940	COG0745	RESPONSE REGULATOR receiver
HBM78_RS14960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBM78_RS14970	COG2205	protein histidine kinase activity
HBM78_RS15040	COG4993	Dehydrogenase
HBM78_RS15060	COG0384	phenazine biosynthesis protein PhzF
HBM78_RS15080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBM78_RS15095	COG0583	DNA-binding transcription factor activity
HBM78_RS15115	COG1473	amidohydrolase
HBM78_RS15125	COG0583	DNA-binding transcription factor activity
HBM78_RS15140	COG0583	DNA-binding transcription factor activity
HBM78_RS15145	COG1053	succinate dehydrogenase
HBM78_RS15155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HBM78_RS15160	COG2814	Major facilitator Superfamily
HBM78_RS15165	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS15170	COG0583	DNA-binding transcription factor activity
HBM78_RS15175	COG1063	alcohol dehydrogenase
HBM78_RS15205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBM78_RS15210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HBM78_RS15215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM78_RS15230	COG3667	copper resistance
HBM78_RS15235	COG2132	Multicopper oxidase
HBM78_RS15245	COG0561	phosphatase activity
HBM78_RS15250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBM78_RS15275	COG1214	PFAM Peptidase M22, glycoprotease
HBM78_RS15325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBM78_RS15335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBM78_RS15340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBM78_RS15345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HBM78_RS15405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBM78_RS15415	COG1846	Transcriptional regulator
HBM78_RS15420	COG1764	response to oxidative stress
HBM78_RS15470	COG0037	tRNA processing
HBM78_RS15480	COG0248	Ppx GppA phosphatase
HBM78_RS15510	COG0072	phenylalanine-tRNA ligase activity
HBM78_RS15550	COG1238	metal cluster binding
HBM78_RS15555	COG0625	glutathione transferase activity
HBM78_RS15570	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_RS15575	COG3028	Belongs to the UPF0307 family
HBM78_RS15580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBM78_RS15600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBM78_RS15605	COG0617	tRNA 3'-terminal CCA addition
HBM78_RS15610	COG1555	photosystem II stabilization
HBM78_RS15615	COG3956	TIGRFAM MazG family protein
HBM78_RS15625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBM78_RS15645	COG5002	protein histidine kinase activity
HBM78_RS15645	COG0784	Response regulator, receiver
HBM78_RS15645	COG2205	protein histidine kinase activity
HBM78_RS15650	COG1024	Enoyl-CoA hydratase
HBM78_RS15655	COG2084	Dehydrogenase
HBM78_RS15660	COG3622	Belongs to the hyi family
HBM78_RS15690	COG0697	spore germination
HBM78_RS15700	COG2814	Major facilitator Superfamily
HBM78_RS15705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBM78_RS15715	COG0583	DNA-binding transcription factor activity
HBM78_RS15725	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBM78_RS15740	COG0084	hydrolase, TatD family'
HBM78_RS15755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HBM78_RS15785	COG0440	acetolactate synthase activity
HBM78_RS15790	COG0028	Belongs to the TPP enzyme family
HBM78_RS15815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBM78_RS15820	COG0577	efflux transmembrane transporter activity
HBM78_RS15820	COG1136	(ABC) transporter
HBM78_RS15825	COG1538	Outer membrane efflux protein
HBM78_RS15840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HBM78_RS15845	COG1162	GTPase activity
HBM78_RS15855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBM78_RS15875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HBM78_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS15920	COG2986	histidine ammonia-lyase
HBM78_RS15935	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_RS15945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM78_RS15990	COG1426	Protein conserved in bacteria
HBM78_RS16025	COG0793	Belongs to the peptidase S41A family
HBM78_RS16040	COG2267	carboxylic ester hydrolase activity
HBM78_RS16050	COG1012	belongs to the aldehyde dehydrogenase family
HBM78_RS16055	COG3265	gluconokinase activity
HBM78_RS16065	COG0800	Aldolase
HBM78_RS16080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBM78_RS16085	COG0280	phosphate acetyltransferase
HBM78_RS16085	COG0857	belongs to the CobB CobQ family
HBM78_RS16090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM78_RS16090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HBM78_RS16110	COG0740	serine-type endopeptidase activity
HBM78_RS16120	COG4774	siderophore transport
HBM78_RS16130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBM78_RS16140	COG2813	Specifically methylates the guanine in position
HBM78_RS16140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBM78_RS16240	COG0788	formyltetrahydrofolate deformylase activity
HBM78_RS16265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_RS16265	COG4651	solute:proton antiporter activity
HBM78_RS16285	COG0724	RNA recognition motif
HBM78_RS16290	COG0210	DNA helicase
HBM78_RS16315	COG1733	regulation of RNA biosynthetic process
HBM78_RS16325	COG2900	Belongs to the SlyX family
HBM78_RS16335	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS16340	COG1560	Kdo2-lipid A biosynthetic process
HBM78_RS16350	COG1301	dicarboxylic acid transport
HBM78_RS16405	COG0473	3-isopropylmalate dehydrogenase activity
HBM78_RS16470	COG0583	DNA-binding transcription factor activity
HBM78_RS16480	COG0625	glutathione transferase activity
HBM78_RS16485	COG2378	regulation of single-species biofilm formation
HBM78_RS16490	COG0546	phosphoglycolate phosphatase activity
HBM78_RS16505	COG1530	ribonuclease E activity
HBM78_RS16510	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_RS16525	COG0583	DNA-binding transcription factor activity
HBM78_RS16530	COG4221	oxidoreductase activity
HBM78_RS16535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBM78_RS16545	COG0534	Mate efflux family protein
HBM78_RS16560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBM78_RS16600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBM78_RS16605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBM78_RS16620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBM78_RS16630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HBM78_RS16630	COG0644	oxidoreductase
HBM78_RS16635	COG0425	Belongs to the sulfur carrier protein TusA family
HBM78_RS16640	COG4535	Mg2 and Co2 transporter CorC
HBM78_RS16650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBM78_RS16670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBM78_RS16675	COG0475	glutathione-regulated potassium exporter activity
HBM78_RS16675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBM78_RS16680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HBM78_RS16690	COG0484	heat shock protein binding
HBM78_RS16695	COG0789	Transcriptional regulator
HBM78_RS16700	COG0598	Magnesium transport protein CorA
HBM78_RS16720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBM78_RS16725	COG1074	ATP-dependent DNA helicase activity
HBM78_RS16730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBM78_RS16750	COG2226	methyltransferase
HBM78_RS16765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBM78_RS16770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBM78_RS16785	COG2111	Na H antiporter
HBM78_RS16785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBM78_RS16790	COG1006	Multisubunit Na H antiporter MnhC subunit
HBM78_RS16795	COG0651	ATP synthesis coupled electron transport
HBM78_RS16805	COG2212	antiporter activity
HBM78_RS16825	COG0195	Participates in both transcription termination and antitermination
HBM78_RS16875	COG0237	dephospho-CoA kinase activity
HBM78_RS16885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBM78_RS16900	COG0497	DNA recombination
HBM78_RS16910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HBM78_RS16940	COG2169	Transcriptional regulator
HBM78_RS16940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBM78_RS16945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBM78_RS17010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HBM78_RS17025	COG0326	Molecular chaperone. Has ATPase activity
HBM78_RS17040	COG2056	Na+-H+ antiporter family
HBM78_RS17045	COG0596	Alpha beta hydrolase
HBM78_RS17140	COG0546	phosphoglycolate phosphatase activity
HBM78_RS17145	COG1716	ATPase activity
HBM78_RS17190	COG0181	hydroxymethylbilane synthase activity
HBM78_RS17200	COG3275	phosphorelay sensor kinase activity
HBM78_RS17220	COG1538	Outer membrane efflux protein
HBM78_RS17225	COG0697	spore germination
HBM78_RS17250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBM78_RS17255	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBM78_RS17260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBM78_RS17265	COG0772	Belongs to the SEDS family
HBM78_RS17290	COG4974	Belongs to the 'phage' integrase family
HBM78_RS17295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_RS17305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBM78_RS17315	COG2197	response regulator
HBM78_RS17330	COG0793	Belongs to the peptidase S41A family
HBM78_RS17335	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HBM78_RS17340	COG0795	lipopolysaccharide-transporting ATPase activity
HBM78_RS17380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM78_RS17380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBM78_RS17390	COG0004	ammonium transporteR
HBM78_RS17395	COG0347	Belongs to the P(II) protein family
HBM78_RS17405	COG0606	chelatase, subunit chli
HBM78_RS17480	COG1061	Type III restriction enzyme res subunit
HBM78_RS17495	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_RS17500	COG0589	response to stress
HBM78_RS17545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_RS17595	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBM78_RS17640	COG1061	Type III restriction enzyme res subunit
HBM78_RS17655	COG0659	secondary active sulfate transmembrane transporter activity
HBM78_RS17660	COG0589	response to stress
HBM78_RS17690	COG0606	chelatase, subunit chli
HBM78_RS17705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBM78_RS17720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBM78_RS17735	COG0318	PFAM AMP-dependent synthetase and ligase
HBM78_RS17745	COG0477	Major facilitator Superfamily
HBM78_RS17750	COG2860	membrane
HBM78_RS17760	COG1253	flavin adenine dinucleotide binding
HBM78_RS17780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBM78_RS17815	COG0655	NAD(P)H dehydrogenase (quinone) activity
HBM78_RS17825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBM78_RS17860	COG1309	transcriptional regulator
HBM78_RS17895	COG0758	DNA mediated transformation
HBM78_RS17905	COG0697	spore germination
HBM78_RS17910	COG1309	transcriptional regulator
HBM78_RS17925	COG0386	Belongs to the glutathione peroxidase family
HBM78_RS17990	COG1121	(ABC) transporter
HBM78_RS17995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBM78_RS18000	COG1280	lysine exporter protein (LysE YggA)
HBM78_RS18005	COG2837	iron assimilation
HBM78_RS18015	COG0281	malic enzyme
HBM78_RS18060	COG0519	Catalyzes the synthesis of GMP from XMP
HBM78_RS18060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBM78_RS18065	COG4399	Belongs to the UPF0754 family
HBM78_RS18070	COG2259	Doxx family
HBM78_RS18075	COG0586	Pfam SNARE associated Golgi protein
HBM78_RS18090	COG1192	Involved in chromosome partitioning
HBM78_RS18100	COG0271	Belongs to the BolA IbaG family
HBM78_RS18120	COG2267	carboxylic ester hydrolase activity
HBM78_RS18140	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HBM78_RS18140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBM78_RS18140	COG3321	synthase
HBM78_RS18140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HBM78_RS18145	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS18155	COG2197	response regulator
HBM78_RS18165	COG3916	Acyl-homoserine-lactone synthase
HBM78_RS18170	COG0477	Major facilitator Superfamily
HBM78_RS18175	COG1024	Enoyl-CoA hydratase
HBM78_RS18180	COG1024	Enoyl-CoA hydratase
HBM78_RS18185	COG1960	acyl-CoA dehydrogenase activity
HBM78_RS18190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBM78_RS18210	COG1113	amino acid transport
HBM78_RS18215	COG1113	amino acid transport
HBM78_RS18220	COG0251	oxidation-reduction process
HBM78_RS18260	COG0564	pseudouridine synthase activity
HBM78_RS18320	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HBM78_RS18335	COG1802	Transcriptional regulator
HBM78_RS18345	COG1448	Aminotransferase
HBM78_RS18350	COG0277	FAD linked oxidase domain protein
HBM78_RS18360	COG2186	Transcriptional regulator
HBM78_RS18370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBM78_RS18375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBM78_RS18390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBM78_RS18395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBM78_RS18400	COG1216	Glycosyl transferase, family 2
HBM78_RS18430	COG2089	acid synthase
HBM78_RS18445	COG1083	cytidylyl-transferase
HBM78_RS18450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HBM78_RS18455	COG1086	Polysaccharide biosynthesis protein
HBM78_RS18460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HBM78_RS18465	COG1596	polysaccharide export
HBM78_RS18490	COG0728	peptidoglycan biosynthetic process
HBM78_RS18495	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBM78_RS18550	COG0546	phosphoglycolate phosphatase activity
HBM78_RS18555	COG1028	Short-chain dehydrogenase reductase Sdr
HBM78_RS18575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_RS18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBM78_RS18585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBM78_RS18590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBM78_RS18595	COG1116	anion transmembrane transporter activity
HBM78_RS18600	COG1309	transcriptional regulator
HBM78_RS18605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBM78_RS18615	COG0196	riboflavin kinase activity
HBM78_RS18620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HBM78_RS18630	COG1047	Peptidyl-prolyl cis-trans
HBM78_RS18670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBM78_RS18725	COG2951	lytic endotransglycosylase activity
HBM78_RS18730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBM78_RS18745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBM78_RS18755	COG0671	phosphoesterase, PA-phosphatase related
HBM78_RS18760	COG0861	Integral membrane protein TerC family
HBM78_RS18770	COG0754	glutathionylspermidine amidase activity
HBM78_RS18780	COG0402	S-adenosylhomocysteine deaminase activity
HBM78_RS18795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBM78_RS18800	COG1230	cation diffusion facilitator family transporter
HBM78_RS18815	COG0706	membrane insertase activity