locus-tag	class	description
HBK86_RS00005	COG1301	dicarboxylic acid transport
HBK86_RS00015	COG1560	Kdo2-lipid A biosynthetic process
HBK86_RS00020	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS00035	COG2900	Belongs to the SlyX family
HBK86_RS00045	COG1733	regulation of RNA biosynthetic process
HBK86_RS00070	COG0210	DNA helicase
HBK86_RS00075	COG0724	RNA recognition motif
HBK86_RS00095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBK86_RS00095	COG4651	solute:proton antiporter activity
HBK86_RS00120	COG0788	formyltetrahydrofolate deformylase activity
HBK86_RS00225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBK86_RS00225	COG2813	Specifically methylates the guanine in position
HBK86_RS00235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBK86_RS00245	COG4774	siderophore transport
HBK86_RS00320	COG3267	Type II secretory pathway component ExeA
HBK86_RS00320	COG3409	Peptidoglycan-binding domain 1 protein
HBK86_RS00350	COG0681	Belongs to the peptidase S26 family
HBK86_RS00385	COG4373	Mu-like prophage FluMu protein gp28
HBK86_RS00395	COG4383	Mu-like prophage protein gp29
HBK86_RS00400	COG2369	cell adhesion
HBK86_RS00405	COG5005	Phage virion morphogenesis
HBK86_RS00420	COG4397	Mu-like prophage major head subunit gpT
HBK86_RS00520	COG0740	serine-type endopeptidase activity
HBK86_RS00540	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HBK86_RS00540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HBK86_RS00545	COG0280	phosphate acetyltransferase
HBK86_RS00545	COG0857	belongs to the CobB CobQ family
HBK86_RS00550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HBK86_RS00560	COG0800	Aldolase
HBK86_RS00570	COG3265	gluconokinase activity
HBK86_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS00585	COG2267	carboxylic ester hydrolase activity
HBK86_RS00600	COG0793	Belongs to the peptidase S41A family
HBK86_RS00635	COG1426	Protein conserved in bacteria
HBK86_RS00675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HBK86_RS00685	COG1162	GTPase activity
HBK86_RS00690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HBK86_RS00705	COG1538	Outer membrane efflux protein
HBK86_RS00710	COG1136	(ABC) transporter
HBK86_RS00710	COG0577	efflux transmembrane transporter activity
HBK86_RS00715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS00740	COG0028	Belongs to the TPP enzyme family
HBK86_RS00745	COG0440	acetolactate synthase activity
HBK86_RS00775	COG3501	Rhs element vgr protein
HBK86_RS00800	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HBK86_RS00815	COG0084	hydrolase, TatD family'
HBK86_RS00830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HBK86_RS00840	COG0583	DNA-binding transcription factor activity
HBK86_RS00850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBK86_RS00945	COG2205	protein histidine kinase activity
HBK86_RS00960	COG2132	Multicopper oxidase
HBK86_RS00970	COG0789	Transcriptional regulator
HBK86_RS01005	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBK86_RS01020	COG0640	Transcriptional regulator
HBK86_RS01030	COG0798	PFAM Bile acid sodium symporter
HBK86_RS01035	COG0431	NADPH-dependent FMN reductase
HBK86_RS01050	COG2814	Major facilitator Superfamily
HBK86_RS01060	COG0697	spore germination
HBK86_RS01090	COG3622	Belongs to the hyi family
HBK86_RS01095	COG2084	Dehydrogenase
HBK86_RS01100	COG1024	Enoyl-CoA hydratase
HBK86_RS01105	COG0784	Response regulator, receiver
HBK86_RS01105	COG5002	protein histidine kinase activity
HBK86_RS01105	COG2205	protein histidine kinase activity
HBK86_RS01125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBK86_RS01135	COG3956	TIGRFAM MazG family protein
HBK86_RS01140	COG1555	photosystem II stabilization
HBK86_RS01145	COG0617	tRNA 3'-terminal CCA addition
HBK86_RS01150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HBK86_RS01170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBK86_RS01175	COG3028	Belongs to the UPF0307 family
HBK86_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
HBK86_RS01195	COG0625	glutathione transferase activity
HBK86_RS01200	COG1238	metal cluster binding
HBK86_RS01240	COG0072	phenylalanine-tRNA ligase activity
HBK86_RS01270	COG0248	Ppx GppA phosphatase
HBK86_RS01280	COG0037	tRNA processing
HBK86_RS01320	COG1764	response to oxidative stress
HBK86_RS01325	COG1846	Transcriptional regulator
HBK86_RS01335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBK86_RS01395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HBK86_RS01400	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HBK86_RS01405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HBK86_RS01415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HBK86_RS01465	COG1214	PFAM Peptidase M22, glycoprotease
HBK86_RS01480	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HBK86_RS01490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HBK86_RS01495	COG0561	phosphatase activity
HBK86_RS01505	COG2132	Multicopper oxidase
HBK86_RS01525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBK86_RS01530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HBK86_RS01535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HBK86_RS01570	COG1063	alcohol dehydrogenase
HBK86_RS01575	COG0583	DNA-binding transcription factor activity
HBK86_RS01580	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS01585	COG2814	Major facilitator Superfamily
HBK86_RS01590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HBK86_RS01600	COG1053	succinate dehydrogenase
HBK86_RS01605	COG0583	DNA-binding transcription factor activity
HBK86_RS01620	COG0583	DNA-binding transcription factor activity
HBK86_RS01630	COG1473	amidohydrolase
HBK86_RS01650	COG0583	DNA-binding transcription factor activity
HBK86_RS01665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS01690	COG0384	phenazine biosynthesis protein PhzF
HBK86_RS01700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HBK86_RS01720	COG0745	RESPONSE REGULATOR receiver
HBK86_RS01725	COG2205	protein histidine kinase activity
HBK86_RS01760	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HBK86_RS01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBK86_RS01795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HBK86_RS01815	COG0583	DNA-binding transcription factor activity
HBK86_RS01835	COG0668	transmembrane transport
HBK86_RS01845	COG2081	HI0933 family
HBK86_RS01850	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HBK86_RS01880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBK86_RS01880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBK86_RS01890	COG0489	protein tyrosine kinase activity
HBK86_RS01945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HBK86_RS01955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HBK86_RS01970	COG0730	response to heat
HBK86_RS01980	COG1196	nuclear chromosome segregation
HBK86_RS02000	COG2223	nitrite transmembrane transporter activity
HBK86_RS02005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HBK86_RS02010	COG1877	trehalose-phosphatase activity
HBK86_RS02015	COG0596	Alpha beta hydrolase
HBK86_RS02015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBK86_RS02015	COG2226	methyltransferase
HBK86_RS02030	COG4106	trans-aconitate 2-methyltransferase activity
HBK86_RS02045	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HBK86_RS02050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HBK86_RS02055	COG0009	L-threonylcarbamoyladenylate synthase
HBK86_RS02060	COG3101	peptidyl-lysine hydroxylation
HBK86_RS02065	COG1399	metal-binding, possibly nucleic acid-binding protein
HBK86_RS02090	COG1652	LysM domain
HBK86_RS02095	COG0351	phosphomethylpyrimidine kinase
HBK86_RS02095	COG0352	thiamine-phosphate diphosphorylase activity
HBK86_RS02095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBK86_RS02105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HBK86_RS02135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBK86_RS02165	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HBK86_RS02180	COG0358	DNA primase activity
HBK86_RS02190	COG0564	pseudouridine synthase activity
HBK86_RS02215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBK86_RS02235	COG0583	DNA-binding transcription factor activity
HBK86_RS02240	COG0473	3-isopropylmalate dehydrogenase activity
HBK86_RS02260	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS02280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HBK86_RS02280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HBK86_RS02340	COG0456	acetyltransferase
HBK86_RS02350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HBK86_RS02355	COG0492	ferredoxin-NADP+ reductase activity
HBK86_RS02360	COG1674	ftsk spoiiie
HBK86_RS02360	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HBK86_RS02365	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS02385	COG2894	cell division
HBK86_RS02400	COG0204	Acyl-transferase
HBK86_RS02405	COG2885	chlorophyll binding
HBK86_RS02410	COG0210	DNA helicase
HBK86_RS02420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBK86_RS02435	COG0121	glutamine amidotransferase
HBK86_RS02455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HBK86_RS02460	COG0735	belongs to the Fur family
HBK86_RS02485	COG0420	3'-5' exonuclease activity
HBK86_RS02505	COG1090	epimerase
HBK86_RS02520	COG2050	protein possibly involved in aromatic compounds catabolism
HBK86_RS02530	COG2814	Major facilitator Superfamily
HBK86_RS02535	COG0405	Gamma-glutamyltransferase
HBK86_RS02600	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HBK86_RS02610	COG0477	Major facilitator Superfamily
HBK86_RS02615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBK86_RS02625	COG1595	DNA-templated transcription, initiation
HBK86_RS02680	COG0531	amino acid
HBK86_RS02685	COG2040	homocysteine
HBK86_RS02710	COG1309	transcriptional regulator
HBK86_RS02715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBK86_RS02720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBK86_RS02730	COG1607	acyl-coa hydrolase
HBK86_RS02740	COG0523	cobalamin synthesis protein
HBK86_RS02750	COG4681	YaeQ
HBK86_RS02760	COG0726	polysaccharide deacetylase
HBK86_RS02760	COG1649	PFAM Uncharacterised BCR, COG1649
HBK86_RS02765	COG1215	transferase activity, transferring glycosyl groups
HBK86_RS02775	COG1024	Enoyl-CoA hydratase
HBK86_RS02790	COG1414	Transcriptional regulator
HBK86_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS02825	COG2271	Major facilitator Superfamily
HBK86_RS02835	COG2267	carboxylic ester hydrolase activity
HBK86_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS02855	COG0028	Belongs to the TPP enzyme family
HBK86_RS02865	COG0477	Major facilitator Superfamily
HBK86_RS02870	COG0242	peptide deformylase activity
HBK86_RS02875	COG2066	Belongs to the glutaminase family
HBK86_RS02880	COG2207	Transcriptional regulator
HBK86_RS02885	COG2223	nitrite transmembrane transporter activity
HBK86_RS02900	COG0583	DNA-binding transcription factor activity
HBK86_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS02910	COG2271	Major facilitator Superfamily
HBK86_RS02915	COG3959	Transketolase, thiamine diphosphate binding domain
HBK86_RS02920	COG3958	Transketolase
HBK86_RS02930	COG0306	phosphate transporter
HBK86_RS02950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBK86_RS02995	COG4181	ATPase activity
HBK86_RS03000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HBK86_RS03030	COG0583	DNA-binding transcription factor activity
HBK86_RS03040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBK86_RS03045	COG1773	rubredoxin
HBK86_RS03095	COG2851	Citrate transporter
HBK86_RS03100	COG1253	flavin adenine dinucleotide binding
HBK86_RS03140	COG0804	urea catabolic process
HBK86_RS03150	COG0830	nickel cation binding
HBK86_RS03165	COG0742	ribosomal rna small subunit methyltransferase
HBK86_RS03170	COG0768	penicillin binding
HBK86_RS03195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HBK86_RS03200	COG2878	Part of a membrane complex involved in electron transport
HBK86_RS03205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBK86_RS03215	COG3384	dioxygenase
HBK86_RS03235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HBK86_RS03275	COG0006	proline dipeptidase activity
HBK86_RS03280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS03285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS03305	COG1279	arginine transmembrane transporter activity
HBK86_RS03310	COG0583	DNA-binding transcription factor activity
HBK86_RS03350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBK86_RS03355	COG0741	lytic transglycosylase activity
HBK86_RS03355	COG0741	lytic transglycosylase activity
HBK86_RS03355	COG1388	LysM domain
HBK86_RS03355	COG1388	LysM domain
HBK86_RS03365	COG4174	ABC transporter (Permease)
HBK86_RS03370	COG4239	(ABC) transporter, permease
HBK86_RS03375	COG4172	Belongs to the ABC transporter superfamily
HBK86_RS03400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HBK86_RS03410	COG4251	negative regulation of phosphorylation
HBK86_RS03410	COG3706	GGDEF domain
HBK86_RS03410	COG2203	Gaf domain
HBK86_RS03410	COG5001	Diguanylate cyclase
HBK86_RS03425	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBK86_RS03425	COG1902	pentaerythritol trinitrate reductase activity
HBK86_RS03455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBK86_RS03465	COG0583	DNA-binding transcription factor activity
HBK86_RS03475	COG2814	Major facilitator Superfamily
HBK86_RS03490	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS03495	COG1454	alcohol dehydrogenase
HBK86_RS03500	COG3485	protocatechuate 3,4-dioxygenase
HBK86_RS03515	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBK86_RS03520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBK86_RS03525	COG0183	Belongs to the thiolase family
HBK86_RS03560	COG1113	amino acid transport
HBK86_RS03570	COG0531	amino acid
HBK86_RS03590	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS03610	COG1113	amino acid transport
HBK86_RS03625	COG0697	spore germination
HBK86_RS03630	COG2721	sulfolactate sulfo-lyase activity
HBK86_RS03635	COG2271	Major facilitator Superfamily
HBK86_RS03640	COG4948	Mandelate Racemase Muconate Lactonizing
HBK86_RS03650	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS03655	COG2186	Transcriptional regulator
HBK86_RS03680	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS03690	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS03695	COG1024	Enoyl-CoA hydratase
HBK86_RS03700	COG2814	Major facilitator Superfamily
HBK86_RS03715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBK86_RS03730	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HBK86_RS03770	COG2207	Transcriptional regulator
HBK86_RS03775	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HBK86_RS03780	COG2072	flavoprotein involved in K transport
HBK86_RS03785	COG0300	oxidoreductase activity
HBK86_RS03795	COG1309	transcriptional regulator
HBK86_RS03800	COG1741	Belongs to the pirin family
HBK86_RS03815	COG2072	flavoprotein involved in K transport
HBK86_RS03825	COG2252	PERMEase
HBK86_RS03830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HBK86_RS03835	COG3038	cytochrome b561
HBK86_RS03845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HBK86_RS03855	COG0527	aspartate kinase activity
HBK86_RS03865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HBK86_RS03875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HBK86_RS03890	COG0667	Aldo Keto reductase
HBK86_RS03900	COG1765	OsmC-like protein
HBK86_RS03915	COG0542	response to heat
HBK86_RS03950	COG2885	chlorophyll binding
HBK86_RS03960	COG0625	glutathione transferase activity
HBK86_RS03965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HBK86_RS03985	COG3634	alkyl hydroperoxide reductase activity
HBK86_RS03995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HBK86_RS04005	COG0450	alkyl hydroperoxide reductase
HBK86_RS04010	COG1643	Atp-dependent helicase
HBK86_RS04025	COG2814	Major facilitator Superfamily
HBK86_RS04030	COG3135	benzoate transporter
HBK86_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS04040	COG0543	2 iron, 2 sulfur cluster binding
HBK86_RS04040	COG0633	Ferredoxin
HBK86_RS04045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBK86_RS04050	COG4638	Rieske (2fe-2S)
HBK86_RS04060	COG0583	DNA-binding transcription factor activity
HBK86_RS04070	COG2871	sodium ion transport
HBK86_RS04150	COG1570	exodeoxyribonuclease VII activity
HBK86_RS04185	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS04190	COG1278	Cold shock
HBK86_RS04225	COG2814	Major facilitator Superfamily
HBK86_RS04395	COG5410	chromosome segregation
HBK86_RS04400	COG3567	Phage-associated protein, HI1409 family
HBK86_RS04420	COG3566	protein conserved in bacteria
HBK86_RS04570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HBK86_RS04580	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HBK86_RS04585	COG1137	ATPase activity
HBK86_RS04595	COG1538	Outer membrane efflux protein
HBK86_RS04625	COG4122	O-methyltransferase activity
HBK86_RS04635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HBK86_RS04650	COG1522	sequence-specific DNA binding
HBK86_RS04655	COG5006	permease, DMT superfamily
HBK86_RS04665	COG1560	Kdo2-lipid A biosynthetic process
HBK86_RS04670	COG0598	Magnesium transport protein CorA
HBK86_RS04685	COG2814	Major facilitator Superfamily
HBK86_RS04705	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBK86_RS04725	COG0583	DNA-binding transcription factor activity
HBK86_RS04730	COG1914	H( )-stimulated, divalent metal cation uptake system
HBK86_RS04750	COG4770	biotin carboxylase activity
HBK86_RS04755	COG0038	chloride channel
HBK86_RS04760	COG2831	hemolysin activation secretion protein
HBK86_RS04765	COG3210	domain, Protein
HBK86_RS04775	COG1309	transcriptional regulator
HBK86_RS04785	COG1063	alcohol dehydrogenase
HBK86_RS04800	COG0439	Biotin carboxylase
HBK86_RS04805	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBK86_RS04810	COG1733	regulation of RNA biosynthetic process
HBK86_RS04820	COG0864	Transcriptional regulator
HBK86_RS04830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBK86_RS04835	COG1116	anion transmembrane transporter activity
HBK86_RS04995	COG0590	tRNA wobble adenosine to inosine editing
HBK86_RS05000	COG2807	transmembrane transport
HBK86_RS05015	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HBK86_RS05025	COG0789	Transcriptional regulator
HBK86_RS05035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBK86_RS05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HBK86_RS05080	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS05085	COG0531	amino acid
HBK86_RS05090	COG1760	l-serine dehydratase
HBK86_RS05095	COG2030	dehydratase
HBK86_RS05095	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS05100	COG3396	Phenylacetate-CoA oxygenase
HBK86_RS05105	COG3460	Phenylacetate-CoA oxygenase
HBK86_RS05110	COG3396	Phenylacetate-CoA oxygenase
HBK86_RS05115	COG2151	metal-sulfur cluster biosynthetic enzyme
HBK86_RS05120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBK86_RS05125	COG1024	Enoyl-CoA hydratase
HBK86_RS05130	COG1024	Enoyl-CoA hydratase
HBK86_RS05135	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBK86_RS05140	COG0183	Belongs to the thiolase family
HBK86_RS05145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HBK86_RS05150	COG3327	negative regulation of DNA-templated transcription, initiation
HBK86_RS05160	COG2050	protein possibly involved in aromatic compounds catabolism
HBK86_RS05170	COG0556	nucleotide-excision repair
HBK86_RS05185	COG2207	Transcriptional regulator
HBK86_RS05200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HBK86_RS05205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HBK86_RS05215	COG0753	catalase activity
HBK86_RS05220	COG3038	cytochrome b561
HBK86_RS05240	COG2267	carboxylic ester hydrolase activity
HBK86_RS05245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS05250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS05265	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBK86_RS05275	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS05280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBK86_RS05285	COG0583	DNA-binding transcription factor activity
HBK86_RS05295	COG1414	Transcriptional regulator
HBK86_RS05300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS05310	COG1840	ABC-type Fe3 transport system, periplasmic component
HBK86_RS05315	COG3842	ATPase activity
HBK86_RS05330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HBK86_RS05335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HBK86_RS05340	COG2814	Major facilitator Superfamily
HBK86_RS05345	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS05360	COG1024	Enoyl-CoA hydratase
HBK86_RS05370	COG2814	Major facilitator Superfamily
HBK86_RS05380	COG0183	Belongs to the thiolase family
HBK86_RS05385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HBK86_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS05395	COG1024	Enoyl-CoA hydratase
HBK86_RS05400	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS05410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBK86_RS05415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBK86_RS05425	COG2814	Major facilitator Superfamily
HBK86_RS05435	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS05450	COG0583	DNA-binding transcription factor activity
HBK86_RS05460	COG4770	biotin carboxylase activity
HBK86_RS05465	COG1024	Enoyl-CoA hydratase
HBK86_RS05470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBK86_RS05475	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS05480	COG1309	transcriptional regulator
HBK86_RS05485	COG0318	PFAM AMP-dependent synthetase and ligase
HBK86_RS05505	COG0583	DNA-binding transcription factor activity
HBK86_RS05555	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS05575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBK86_RS05595	COG2205	protein histidine kinase activity
HBK86_RS05595	COG0784	Response regulator, receiver
HBK86_RS05635	COG0765	amino acid transport
HBK86_RS05640	COG0765	amino acid transport
HBK86_RS05650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBK86_RS05655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HBK86_RS05670	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS05675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HBK86_RS05680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBK86_RS05685	COG1045	serine acetyltransferase
HBK86_RS05700	COG0583	DNA-binding transcription factor activity
HBK86_RS05705	COG0625	glutathione transferase activity
HBK86_RS05710	COG0625	glutathione transferase activity
HBK86_RS05715	COG0583	DNA-binding transcription factor activity
HBK86_RS05725	COG1346	cytolysis
HBK86_RS05750	COG0300	oxidoreductase activity
HBK86_RS05760	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HBK86_RS05765	COG3052	prosthetic group binding
HBK86_RS05785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HBK86_RS05805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBK86_RS05815	COG1294	oxidase, subunit
HBK86_RS05820	COG1271	oxidase subunit
HBK86_RS05845	COG0477	Major facilitator Superfamily
HBK86_RS05855	COG4521	taurine ABC transporter
HBK86_RS05860	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HBK86_RS05865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBK86_RS05870	COG2175	clavaminate synthase activity
HBK86_RS05880	COG1953	Uracil, thiamine, allantoin
HBK86_RS05890	COG0583	DNA-binding transcription factor activity
HBK86_RS05900	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HBK86_RS05915	COG0640	Transcriptional regulator
HBK86_RS05920	COG0798	PFAM Bile acid sodium symporter
HBK86_RS05925	COG0583	DNA-binding transcription factor activity
HBK86_RS05940	COG3634	alkyl hydroperoxide reductase activity
HBK86_RS05980	COG0436	Aminotransferase
HBK86_RS05990	COG0386	Belongs to the glutathione peroxidase family
HBK86_RS06030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBK86_RS06055	COG0012	GTP binding
HBK86_RS06060	COG2011	ABC-type metal ion transport system permease component
HBK86_RS06065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBK86_RS06075	COG1464	Belongs to the NlpA lipoprotein family
HBK86_RS06105	COG0765	amino acid transport
HBK86_RS06110	COG0765	amino acid transport
HBK86_RS06115	COG1126	abc transporter atp-binding protein
HBK86_RS06125	COG1522	sequence-specific DNA binding
HBK86_RS06140	COG1309	transcriptional regulator
HBK86_RS06165	COG0583	DNA-binding transcription factor activity
HBK86_RS06180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HBK86_RS06190	COG0697	spore germination
HBK86_RS06215	COG3121	Chaperone
HBK86_RS06220	COG3539	Fimbrial protein
HBK86_RS06245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HBK86_RS06245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HBK86_RS06290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HBK86_RS06300	COG2353	YceI-like domain
HBK86_RS06310	COG3698	Phosphodiester glycosidase
HBK86_RS06325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HBK86_RS06330	COG0506	proline dehydrogenase activity
HBK86_RS06330	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBK86_RS06330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HBK86_RS06340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBK86_RS06345	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HBK86_RS06365	COG1132	(ABC) transporter
HBK86_RS06370	COG3122	Protein conserved in bacteria
HBK86_RS06375	COG3619	membrane
HBK86_RS06385	COG0640	Transcriptional regulator
HBK86_RS06395	COG2850	peptidyl-arginine hydroxylation
HBK86_RS06400	COG0424	maF-like protein
HBK86_RS06420	COG0191	fructose-bisphosphate aldolase activity
HBK86_RS06425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBK86_RS06440	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HBK86_RS06450	COG1192	Involved in chromosome partitioning
HBK86_RS06455	COG1475	DNA binding
HBK86_RS06460	COG0811	peptide transport
HBK86_RS06470	COG1132	(ABC) transporter
HBK86_RS06475	COG1663	tetraacyldisaccharide 4'-kinase activity
HBK86_RS06495	COG0084	hydrolase, TatD family'
HBK86_RS06560	COG0776	regulation of translation
HBK86_RS06590	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HBK86_RS06665	COG0305	Participates in initiation and elongation during chromosome replication
HBK86_RS06745	COG4695	Portal protein
HBK86_RS06800	COG1196	nuclear chromosome segregation
HBK86_RS06800	COG0739	heme binding
HBK86_RS06800	COG0741	lytic transglycosylase activity
HBK86_RS06855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HBK86_RS06895	COG4166	transmembrane transport
HBK86_RS06905	COG0339	signal peptide processing
HBK86_RS06915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBK86_RS06950	COG0702	epimerase
HBK86_RS06955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBK86_RS06975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HBK86_RS07005	COG0316	Belongs to the HesB IscA family
HBK86_RS07010	COG0822	iron-sulfur transferase activity
HBK86_RS07035	COG0776	regulation of translation
HBK86_RS07040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HBK86_RS07045	COG2207	Transcriptional regulator
HBK86_RS07050	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBK86_RS07055	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS07060	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS07075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HBK86_RS07095	COG4264	IucA IucC family
HBK86_RS07100	COG4264	IucA IucC family
HBK86_RS07110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HBK86_RS07155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HBK86_RS07160	COG0406	alpha-ribazole phosphatase activity
HBK86_RS07175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HBK86_RS07185	COG0730	response to heat
HBK86_RS07205	COG4773	Receptor
HBK86_RS07210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBK86_RS07225	COG1131	(ABC) transporter
HBK86_RS07230	COG0842	Transport permease protein
HBK86_RS07235	COG0842	Transport permease protein
HBK86_RS07290	COG2226	methyltransferase
HBK86_RS07320	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HBK86_RS07355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBK86_RS07365	COG0133	tryptophan synthase activity
HBK86_RS07380	COG3706	GGDEF domain
HBK86_RS07395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBK86_RS07400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HBK86_RS07405	COG0022	dehydrogenase e1 component
HBK86_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBK86_RS07415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBK86_RS07425	COG1063	alcohol dehydrogenase
HBK86_RS07430	COG3781	membrane
HBK86_RS07440	COG3453	Protein conserved in bacteria
HBK86_RS07440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBK86_RS07450	COG0730	response to heat
HBK86_RS07465	COG3708	Transcriptional regulator
HBK86_RS07465	COG2207	Transcriptional regulator
HBK86_RS07470	COG1733	regulation of RNA biosynthetic process
HBK86_RS07475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HBK86_RS07485	COG2188	Transcriptional regulator
HBK86_RS07505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBK86_RS07525	COG0477	Major facilitator Superfamily
HBK86_RS07535	COG1027	Aspartate ammonia-lyase
HBK86_RS07550	COG0583	DNA-binding transcription factor activity
HBK86_RS07555	COG0583	DNA-binding transcription factor activity
HBK86_RS07560	COG0183	Belongs to the thiolase family
HBK86_RS07565	COG2031	fatty acid transporter
HBK86_RS07580	COG0583	DNA-binding transcription factor activity
HBK86_RS07600	COG1309	transcriptional regulator
HBK86_RS07610	COG2610	gluconate transmembrane transporter activity
HBK86_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS07620	COG2207	Transcriptional regulator
HBK86_RS07635	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS07645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS07660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBK86_RS07660	COG0543	2 iron, 2 sulfur cluster binding
HBK86_RS07665	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBK86_RS07670	COG4638	Rieske (2fe-2S)
HBK86_RS07680	COG0725	ABC transporter, periplasmic molybdate-binding protein
HBK86_RS07685	COG4149	molybdate abc transporter
HBK86_RS07690	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HBK86_RS07695	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS07700	COG1535	isochorismatase
HBK86_RS07700	COG3433	isochorismatase activity
HBK86_RS07765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBK86_RS07780	COG0753	catalase activity
HBK86_RS07795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HBK86_RS07825	COG3539	Fimbrial protein
HBK86_RS07850	COG0747	negative chemotaxis
HBK86_RS07855	COG0601	transmembrane transport
HBK86_RS07860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HBK86_RS07880	COG1132	(ABC) transporter
HBK86_RS07885	COG1132	(ABC) transporter
HBK86_RS07905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS07920	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HBK86_RS07935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBK86_RS07940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBK86_RS07945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBK86_RS07950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS07980	COG4771	TonB-dependent receptor
HBK86_RS07985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS07995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBK86_RS08000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS08005	COG0745	RESPONSE REGULATOR receiver
HBK86_RS08010	COG2205	protein histidine kinase activity
HBK86_RS08020	COG2207	Transcriptional regulator
HBK86_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS08070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HBK86_RS08120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HBK86_RS08140	COG1120	ATPase activity
HBK86_RS08155	COG1064	alcohol dehydrogenase
HBK86_RS08180	COG2207	Transcriptional regulator
HBK86_RS08185	COG2084	Dehydrogenase
HBK86_RS08195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HBK86_RS08200	COG0583	DNA-binding transcription factor activity
HBK86_RS08210	COG0129	dihydroxy-acid dehydratase activity
HBK86_RS08215	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS08230	COG1566	PFAM secretion protein HlyD family protein
HBK86_RS08240	COG2271	Major facilitator Superfamily
HBK86_RS08255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS08280	COG0583	DNA-binding transcription factor activity
HBK86_RS08295	COG2188	Transcriptional regulator
HBK86_RS08335	COG4993	Dehydrogenase
HBK86_RS08340	COG1733	regulation of RNA biosynthetic process
HBK86_RS08355	COG2259	Doxx family
HBK86_RS08360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HBK86_RS08405	COG1309	transcriptional regulator
HBK86_RS08435	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HBK86_RS08445	COG1902	pentaerythritol trinitrate reductase activity
HBK86_RS08445	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBK86_RS08450	COG1846	Transcriptional regulator
HBK86_RS08475	COG0753	catalase activity
HBK86_RS08490	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS08505	COG3162	membrane
HBK86_RS08515	COG3829	transcription factor binding
HBK86_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS08525	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS08540	COG3231	kanamycin kinase activity
HBK86_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS08565	COG2186	Transcriptional regulator
HBK86_RS08575	COG0583	DNA-binding transcription factor activity
HBK86_RS08580	COG4948	Mandelate Racemase Muconate Lactonizing
HBK86_RS08585	COG4829	muconolactone delta-isomerase
HBK86_RS08595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBK86_RS08600	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBK86_RS08605	COG0183	Belongs to the thiolase family
HBK86_RS08610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HBK86_RS08615	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS08625	COG3733	amine oxidase
HBK86_RS08635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS08655	COG4638	Rieske (2fe-2S)
HBK86_RS08675	COG0154	amidase activity
HBK86_RS08685	COG2814	Major facilitator Superfamily
HBK86_RS08710	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS08715	COG0583	DNA-binding transcription factor activity
HBK86_RS08720	COG1414	Transcriptional regulator
HBK86_RS08735	COG2391	methyltransferase activity
HBK86_RS08745	COG4993	Dehydrogenase
HBK86_RS08750	COG3659	wide pore channel activity
HBK86_RS08755	COG3420	alginic acid biosynthetic process
HBK86_RS08760	COG0710	3-dehydroquinate dehydratase activity
HBK86_RS08765	COG3485	protocatechuate 3,4-dioxygenase
HBK86_RS08770	COG3485	protocatechuate 3,4-dioxygenase
HBK86_RS08775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HBK86_RS08780	COG2271	Major facilitator Superfamily
HBK86_RS08785	COG0596	Alpha beta hydrolase
HBK86_RS08790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HBK86_RS08795	COG0183	Belongs to the thiolase family
HBK86_RS08800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HBK86_RS08805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HBK86_RS08815	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HBK86_RS08865	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBK86_RS08865	COG1902	pentaerythritol trinitrate reductase activity
HBK86_RS08890	COG0542	response to heat
HBK86_RS08895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HBK86_RS08925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBK86_RS08930	COG0569	domain protein
HBK86_RS08935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HBK86_RS08950	COG4774	siderophore transport
HBK86_RS08955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HBK86_RS08965	COG1585	Membrane protein implicated in regulation of membrane protease activity
HBK86_RS08980	COG1294	oxidase, subunit
HBK86_RS08985	COG4890	Cyd operon protein YbgT
HBK86_RS08995	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HBK86_RS09005	COG0552	protein localization to endoplasmic reticulum
HBK86_RS09030	COG0516	GMP reductase activity
HBK86_RS09030	COG0517	IMP dehydrogenase activity
HBK86_RS09035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBK86_RS09040	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HBK86_RS09050	COG0583	DNA-binding transcription factor activity
HBK86_RS09055	COG0024	Methionine aminopeptidase
HBK86_RS09085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HBK86_RS09085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HBK86_RS09090	COG1105	Belongs to the carbohydrate kinase PfkB family
HBK86_RS09095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HBK86_RS09095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBK86_RS09095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HBK86_RS09110	COG3300	MHYT domain
HBK86_RS09110	COG5001	Diguanylate cyclase
HBK86_RS09130	COG2135	peptidase activity
HBK86_RS09135	COG0659	secondary active sulfate transmembrane transporter activity
HBK86_RS09150	COG1113	amino acid transport
HBK86_RS09160	COG1522	sequence-specific DNA binding
HBK86_RS09185	COG1011	Hydrolase
HBK86_RS09190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HBK86_RS09200	COG2137	regulation of response to DNA damage stimulus
HBK86_RS09215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HBK86_RS09250	COG0575	Belongs to the CDS family
HBK86_RS09255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HBK86_RS09280	COG3852	Histidine kinase
HBK86_RS09285	COG2204	response regulator
HBK86_RS09340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBK86_RS09345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HBK86_RS09365	COG0697	spore germination
HBK86_RS09370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBK86_RS09380	COG0303	'Molybdopterin
HBK86_RS09385	COG0315	cyclic pyranopterin monophosphate synthase activity
HBK86_RS09385	COG0521	Mo-molybdopterin cofactor biosynthetic process
HBK86_RS09400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HBK86_RS09405	COG0243	molybdopterin cofactor binding
HBK86_RS09415	COG0243	molybdopterin cofactor binding
HBK86_RS09420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBK86_RS09425	COG2146	nitrite reductase [NAD(P)H] activity
HBK86_RS09425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBK86_RS09435	COG0745	RESPONSE REGULATOR receiver
HBK86_RS09440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBK86_RS09440	COG1116	anion transmembrane transporter activity
HBK86_RS09460	COG0511	ligase activity, forming carbon-carbon bonds
HBK86_RS09475	COG2814	Major facilitator Superfamily
HBK86_RS09515	COG5301	cellulose 1,4-beta-cellobiosidase activity
HBK86_RS09815	COG0069	glutamate synthase activity
HBK86_RS09835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HBK86_RS09845	COG1454	alcohol dehydrogenase
HBK86_RS09850	COG0824	Thioesterase
HBK86_RS09860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HBK86_RS09890	COG2030	dehydratase
HBK86_RS09900	COG0183	Belongs to the thiolase family
HBK86_RS09910	COG0583	DNA-binding transcription factor activity
HBK86_RS09915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HBK86_RS09925	COG1522	sequence-specific DNA binding
HBK86_RS09930	COG3135	benzoate transporter
HBK86_RS09940	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HBK86_RS09965	COG0589	response to stress
HBK86_RS09970	COG0488	(ABC) transporter
HBK86_RS09990	COG4773	Receptor
HBK86_RS10020	COG0668	transmembrane transport
HBK86_RS10075	COG2814	Major facilitator Superfamily
HBK86_RS10080	COG2814	Major facilitator Superfamily
HBK86_RS10085	COG0446	pyridine nucleotide-disulphide oxidoreductase
HBK86_RS10090	COG3384	dioxygenase
HBK86_RS10095	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS10105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HBK86_RS10110	COG4638	Rieske (2fe-2S)
HBK86_RS10115	COG0583	DNA-binding transcription factor activity
HBK86_RS10135	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HBK86_RS10140	COG3971	2-oxopent-4-enoate hydratase activity
HBK86_RS10150	COG2271	Major facilitator Superfamily
HBK86_RS10155	COG1234	tRNA 3'-trailer cleavage
HBK86_RS10185	COG1538	Outer membrane efflux protein
HBK86_RS10195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBK86_RS10195	COG2885	chlorophyll binding
HBK86_RS10250	COG1605	Chorismate mutase
HBK86_RS10270	COG0308	aminopeptidase N
HBK86_RS10290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HBK86_RS10300	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBK86_RS10305	COG1454	alcohol dehydrogenase
HBK86_RS10325	COG0531	amino acid
HBK86_RS10330	COG4303	Ethanolamine ammonia lyase large subunit
HBK86_RS10335	COG4302	ethanolamine ammonia-lyase activity
HBK86_RS10340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBK86_RS10340	COG0519	Catalyzes the synthesis of GMP from XMP
HBK86_RS10345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBK86_RS10370	COG0697	spore germination
HBK86_RS10375	COG1923	regulation of RNA biosynthetic process
HBK86_RS10385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HBK86_RS10390	COG0802	atpase or kinase
HBK86_RS10410	COG1187	pseudouridine synthase activity
HBK86_RS10425	COG0583	DNA-binding transcription factor activity
HBK86_RS10445	COG2814	Major facilitator Superfamily
HBK86_RS10450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HBK86_RS10475	COG0729	surface antigen
HBK86_RS10495	COG0174	glutamine synthetase
HBK86_RS10500	COG0745	RESPONSE REGULATOR receiver
HBK86_RS10505	COG2205	protein histidine kinase activity
HBK86_RS10515	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HBK86_RS10520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HBK86_RS10545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS10550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBK86_RS10555	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS10585	COG0583	DNA-binding transcription factor activity
HBK86_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS10610	COG3658	cytochrome
HBK86_RS10615	COG1215	transferase activity, transferring glycosyl groups
HBK86_RS10620	COG0726	polysaccharide deacetylase
HBK86_RS10620	COG1649	PFAM Uncharacterised BCR, COG1649
HBK86_RS10645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HBK86_RS10650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HBK86_RS10660	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HBK86_RS10685	COG0305	Participates in initiation and elongation during chromosome replication
HBK86_RS10690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HBK86_RS10700	COG1305	Transglutaminase-like
HBK86_RS10710	COG2308	Evidence 4 Homologs of previously reported genes of
HBK86_RS10740	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HBK86_RS10745	COG0138	bifunctional purine biosynthesis protein purh
HBK86_RS10750	COG0151	Belongs to the GarS family
HBK86_RS10755	COG1464	Belongs to the NlpA lipoprotein family
HBK86_RS10760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HBK86_RS10765	COG2011	ABC-type metal ion transport system permease component
HBK86_RS10770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBK86_RS10780	COG1301	dicarboxylic acid transport
HBK86_RS10805	COG2814	Major facilitator Superfamily
HBK86_RS10820	COG1309	transcriptional regulator
HBK86_RS10840	COG1794	racemase activity, acting on amino acids and derivatives
HBK86_RS10845	COG3118	belongs to the thioredoxin family
HBK86_RS10845	COG0492	ferredoxin-NADP+ reductase activity
HBK86_RS10860	COG3008	intermembrane lipid transfer
HBK86_RS10860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HBK86_RS10865	COG2995	paraquat-inducible protein a
HBK86_RS10900	COG1051	belongs to the nudix hydrolase family
HBK86_RS10970	COG2186	Transcriptional regulator
HBK86_RS10980	COG0786	glutamate:sodium symporter activity
HBK86_RS10985	COG3243	poly(R)-hydroxyalkanoic acid synthase
HBK86_RS11010	COG3111	PFAM Bacterial OB fold (BOF) protein
HBK86_RS11020	COG2226	methyltransferase
HBK86_RS11100	COG3210	domain, Protein
HBK86_RS11100	COG3210	domain, Protein
HBK86_RS11105	COG2831	hemolysin activation secretion protein
HBK86_RS11130	COG0515	serine threonine protein kinase
HBK86_RS11130	COG2815	serine threonine protein kinase
HBK86_RS11160	COG1610	YqeY-like protein
HBK86_RS11165	COG4783	chaperone-mediated protein folding
HBK86_RS11190	COG1286	toxin biosynthetic process
HBK86_RS11215	COG3179	chitinase
HBK86_RS11370	COG5410	chromosome segregation
HBK86_RS11475	COG0305	Participates in initiation and elongation during chromosome replication
HBK86_RS11600	COG0778	Nitroreductase
HBK86_RS11610	COG0513	Belongs to the DEAD box helicase family
HBK86_RS11630	COG2363	Small membrane protein
HBK86_RS11660	COG4650	regulator
HBK86_RS11665	COG1234	tRNA 3'-trailer cleavage
HBK86_RS11670	COG1690	Belongs to the RtcB family
HBK86_RS11690	COG2195	Cleaves the N-terminal amino acid of tripeptides
HBK86_RS11700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HBK86_RS11710	COG2819	hydrolase of the alpha beta superfamily
HBK86_RS11715	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS11720	COG1301	dicarboxylic acid transport
HBK86_RS11725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HBK86_RS11730	COG3139	Protein of unknown function (DUF1315)
HBK86_RS11735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HBK86_RS11740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HBK86_RS11750	COG0494	nUDIX hydrolase
HBK86_RS11760	COG0642	Histidine kinase
HBK86_RS11765	COG0745	RESPONSE REGULATOR receiver
HBK86_RS11775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HBK86_RS11785	COG1720	tRNA m6t6A37 methyltransferase activity
HBK86_RS11800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBK86_RS11810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HBK86_RS11820	COG4598	ABC transporter
HBK86_RS11825	COG4160	amino acid transport
HBK86_RS11830	COG4215	(ABC) transporter
HBK86_RS11855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS12090	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HBK86_RS12150	COG0582	viral genome integration into host DNA
HBK86_RS12155	COG1131	(ABC) transporter
HBK86_RS12160	COG0842	Transport permease protein
HBK86_RS12175	COG0772	Belongs to the SEDS family
HBK86_RS12180	COG2951	lytic endotransglycosylase activity
HBK86_RS12205	COG2207	Transcriptional regulator
HBK86_RS12220	COG0052	Belongs to the universal ribosomal protein uS2 family
HBK86_RS12225	COG0024	Methionine aminopeptidase
HBK86_RS12235	COG2223	nitrite transmembrane transporter activity
HBK86_RS12245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBK86_RS12250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HBK86_RS12255	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS12270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HBK86_RS12275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HBK86_RS12280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBK86_RS12300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBK86_RS12305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HBK86_RS12310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HBK86_RS12345	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HBK86_RS12355	COG0174	glutamine synthetase
HBK86_RS12360	COG3104	oligopeptide transport
HBK86_RS12370	COG0582	viral genome integration into host DNA
HBK86_RS12515	COG3566	protein conserved in bacteria
HBK86_RS12535	COG3567	Phage-associated protein, HI1409 family
HBK86_RS12540	COG5410	chromosome segregation
HBK86_RS12700	COG0512	Glutamine amidotransferase of anthranilate synthase
HBK86_RS12725	COG2840	Smr protein MutS2
HBK86_RS12735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HBK86_RS12765	COG3739	integral membrane protein
HBK86_RS12780	COG1169	isochorismate synthase
HBK86_RS12790	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HBK86_RS12795	COG5265	(ABC) transporter
HBK86_RS12800	COG1132	(ABC) transporter
HBK86_RS12815	COG1535	isochorismatase
HBK86_RS12815	COG3433	isochorismatase activity
HBK86_RS12820	COG1021	2,3-dihydroxybenzoate-AMP ligase
HBK86_RS12825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBK86_RS12835	COG4774	siderophore transport
HBK86_RS12840	COG4607	ABC-type enterochelin transport system periplasmic component
HBK86_RS12845	COG4604	ABC transporter, ATP-binding protein
HBK86_RS12850	COG4605	iron ion homeostasis
HBK86_RS12855	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HBK86_RS12860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBK86_RS12875	COG2964	Protein conserved in bacteria
HBK86_RS12885	COG1741	Belongs to the pirin family
HBK86_RS12925	COG2879	small protein
HBK86_RS12930	COG1966	Carbon starvation protein
HBK86_RS12950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HBK86_RS12970	COG2211	Major facilitator Superfamily
HBK86_RS12975	COG1067	ATP-dependent peptidase activity
HBK86_RS12980	COG0583	DNA-binding transcription factor activity
HBK86_RS13005	COG1686	Belongs to the peptidase S11 family
HBK86_RS13010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HBK86_RS13045	COG0616	signal peptide processing
HBK86_RS13050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HBK86_RS13060	COG0573	inorganic phosphate transmembrane transporter activity
HBK86_RS13065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HBK86_RS13070	COG1113	amino acid transport
HBK86_RS13075	COG3961	Belongs to the TPP enzyme family
HBK86_RS13080	COG1522	sequence-specific DNA binding
HBK86_RS13090	COG0076	glutamate decarboxylase activity
HBK86_RS13095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBK86_RS13105	COG1309	transcriptional regulator
HBK86_RS13120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBK86_RS13155	COG0352	thiamine-phosphate diphosphorylase activity
HBK86_RS13180	COG1203	CRISPR-associated helicase, Cas3
HBK86_RS13210	COG0612	Peptidase, M16
HBK86_RS13225	COG0583	DNA-binding transcription factor activity
HBK86_RS13230	COG0477	Major facilitator Superfamily
HBK86_RS13255	COG1187	pseudouridine synthase activity
HBK86_RS13270	COG1686	Belongs to the peptidase S11 family
HBK86_RS13275	COG1252	NADH dehydrogenase
HBK86_RS13285	COG0415	Belongs to the DNA photolyase family
HBK86_RS13300	COG1215	transferase activity, transferring glycosyl groups
HBK86_RS13385	COG0556	nucleotide-excision repair
HBK86_RS13405	COG0436	Aminotransferase
HBK86_RS13435	COG4221	oxidoreductase activity
HBK86_RS13445	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HBK86_RS13450	COG1381	Involved in DNA repair and RecF pathway recombination
HBK86_RS13460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HBK86_RS13475	COG0681	Belongs to the peptidase S26 family
HBK86_RS13490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HBK86_RS13510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HBK86_RS13515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HBK86_RS13520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HBK86_RS13530	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HBK86_RS13535	COG4208	sulfate ABC transporter
HBK86_RS13540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HBK86_RS13545	COG0583	DNA-binding transcription factor activity
HBK86_RS13550	COG4625	pathogenesis
HBK86_RS13565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HBK86_RS13580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HBK86_RS13590	COG1056	cytidyltransferase-related domain
HBK86_RS13590	COG1051	belongs to the nudix hydrolase family
HBK86_RS13595	COG1024	Enoyl-CoA hydratase
HBK86_RS13605	COG2814	Major facilitator Superfamily
HBK86_RS13610	COG0047	phosphoribosylformylglycinamidine synthase activity
HBK86_RS13610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HBK86_RS13630	COG1473	amidohydrolase
HBK86_RS13635	COG0824	Thioesterase
HBK86_RS13655	COG0823	Involved in the tonB-independent uptake of proteins
HBK86_RS13675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBK86_RS13710	COG0628	permease
HBK86_RS13720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HBK86_RS13725	COG0596	Alpha beta hydrolase
HBK86_RS13730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HBK86_RS13730	COG0616	signal peptide processing
HBK86_RS13740	COG0658	competence protein
HBK86_RS13740	COG2333	competence protein COMEC
HBK86_RS13745	COG1136	(ABC) transporter
HBK86_RS13750	COG4591	ABC-type transport system involved in lipoprotein release permease component
HBK86_RS13785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS13805	COG0463	Glycosyl transferase, family 2
HBK86_RS13850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBK86_RS13855	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS13865	COG0019	diaminopimelate decarboxylase activity
HBK86_RS13875	COG1113	amino acid transport
HBK86_RS13890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HBK86_RS13900	COG3339	Conserved Protein
HBK86_RS13905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HBK86_RS13910	COG0243	molybdopterin cofactor binding
HBK86_RS13915	COG1929	Belongs to the glycerate kinase type-1 family
HBK86_RS13930	COG0778	Nitroreductase
HBK86_RS13960	COG3811	Belongs to the UPF0386 family
HBK86_RS13985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HBK86_RS14005	COG0741	lytic transglycosylase activity
HBK86_RS14025	COG0584	glycerophosphoryl diester phosphodiesterase
HBK86_RS14050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBK86_RS14055	COG1597	lipid kinase activity
HBK86_RS14070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HBK86_RS14075	COG0477	Major facilitator Superfamily
HBK86_RS14125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HBK86_RS14130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HBK86_RS14155	COG0505	Belongs to the CarA family
HBK86_RS14175	COG0589	response to stress
HBK86_RS14190	COG2843	Capsule synthesis protein
HBK86_RS14210	COG2321	neutral zinc metallopeptidase
HBK86_RS14215	COG2354	Protein conserved in bacteria
HBK86_RS14235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HBK86_RS14260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HBK86_RS14265	COG1053	succinate dehydrogenase
HBK86_RS14270	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HBK86_RS14275	COG2009	succinate dehydrogenase
HBK86_RS14310	COG2921	Belongs to the UPF0250 family
HBK86_RS14315	COG0321	lipoyl(octanoyl) transferase activity
HBK86_RS14330	COG0531	amino acid
HBK86_RS14340	COG1733	regulation of RNA biosynthetic process
HBK86_RS14345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HBK86_RS14350	COG1648	precorrin-2 dehydrogenase activity
HBK86_RS14350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HBK86_RS14365	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HBK86_RS14395	COG0671	phosphoesterase, PA-phosphatase related
HBK86_RS14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS14410	COG1538	Outer membrane efflux protein
HBK86_RS14415	COG0393	Putative heavy-metal-binding
HBK86_RS14420	COG0393	Putative heavy-metal-binding
HBK86_RS14430	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS14440	COG0525	valine-tRNA ligase activity
HBK86_RS14460	COG0583	DNA-binding transcription factor activity
HBK86_RS14465	COG0004	ammonium transporteR
HBK86_RS14475	COG0642	Histidine kinase
HBK86_RS14480	COG0745	RESPONSE REGULATOR receiver
HBK86_RS14485	COG2194	sulfuric ester hydrolase activity
HBK86_RS14505	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBK86_RS14520	COG2315	Protein conserved in bacteria
HBK86_RS14525	COG0142	geranyltranstransferase activity
HBK86_RS14530	COG2828	Protein conserved in bacteria
HBK86_RS14535	COG1113	amino acid transport
HBK86_RS14555	COG2207	Transcriptional regulator
HBK86_RS14580	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBK86_RS14590	COG0560	Phosphoserine phosphatase
HBK86_RS14600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HBK86_RS14610	COG1530	ribonuclease E activity
HBK86_RS14615	COG0424	maF-like protein
HBK86_RS14620	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HBK86_RS14625	COG1792	Involved in formation and maintenance of cell shape
HBK86_RS14630	COG1077	Cell shape determining protein MreB Mrl
HBK86_RS14635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBK86_RS14645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HBK86_RS14670	COG3590	peptidase
HBK86_RS14675	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HBK86_RS14680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HBK86_RS14685	COG1752	Esterase of the alpha-beta hydrolase superfamily
HBK86_RS14690	COG1115	amino acid carrier protein
HBK86_RS14710	COG2814	Major facilitator Superfamily
HBK86_RS14715	COG1289	transmembrane transporter activity
HBK86_RS14725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HBK86_RS14765	COG1376	ErfK ybiS ycfS ynhG family protein
HBK86_RS14770	COG2832	Protein of unknown function (DUF454)
HBK86_RS14780	COG5510	response to toxic substance
HBK86_RS14800	COG0840	transmembrane signaling receptor activity
HBK86_RS14840	COG3422	double-strand break repair
HBK86_RS14845	COG2824	Alkylphosphonate utilization operon protein PhnA
HBK86_RS14850	COG3189	MarR family transcriptional regulator
HBK86_RS14860	COG0354	folic acid binding
HBK86_RS14865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBK86_RS14875	COG0679	Auxin Efflux Carrier
HBK86_RS14880	COG1902	pentaerythritol trinitrate reductase activity
HBK86_RS14885	COG4772	TonB-dependent receptor
HBK86_RS14890	COG2094	Belongs to the DNA glycosylase MPG family
HBK86_RS14920	COG2233	PERMEase
HBK86_RS14930	COG0833	amino acid
HBK86_RS14935	COG1690	Belongs to the RtcB family
HBK86_RS14945	COG2885	chlorophyll binding
HBK86_RS14945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HBK86_RS14955	COG0183	Belongs to the thiolase family
HBK86_RS14975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HBK86_RS14995	COG2207	Transcriptional regulator
HBK86_RS15000	COG0183	Belongs to the thiolase family
HBK86_RS15030	COG1272	protein, Hemolysin III
HBK86_RS15035	COG0477	Major facilitator Superfamily
HBK86_RS15050	COG0450	alkyl hydroperoxide reductase
HBK86_RS15070	COG0285	dihydrofolate synthase activity
HBK86_RS15120	COG2096	Adenosyltransferase
HBK86_RS15125	COG0584	glycerophosphoryl diester phosphodiesterase
HBK86_RS15140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HBK86_RS15145	COG0745	RESPONSE REGULATOR receiver
HBK86_RS15150	COG2205	protein histidine kinase activity
HBK86_RS15160	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS15165	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS15220	COG1442	glycosyl transferase family 8
HBK86_RS15235	COG0438	transferase activity, transferring glycosyl groups
HBK86_RS15245	COG0438	transferase activity, transferring glycosyl groups
HBK86_RS15250	COG0726	polysaccharide deacetylase
HBK86_RS15265	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HBK86_RS15270	COG2205	protein histidine kinase activity
HBK86_RS15300	COG1862	Preprotein translocase
HBK86_RS15310	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HBK86_RS15315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HBK86_RS15325	COG3781	membrane
HBK86_RS15330	COG0613	PHP domain protein
HBK86_RS15340	COG2350	Protein conserved in bacteria
HBK86_RS15370	COG1607	acyl-coa hydrolase
HBK86_RS15430	COG2199	diguanylate cyclase activity
HBK86_RS15440	COG1408	metallophosphoesterase
HBK86_RS15445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HBK86_RS15455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HBK86_RS15475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HBK86_RS15480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HBK86_RS15485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HBK86_RS15495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HBK86_RS15505	COG2969	positive regulation of protein catabolic process
HBK86_RS15525	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS15530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HBK86_RS15545	COG1309	transcriptional regulator
HBK86_RS15595	COG1183	phosphatidylcholine synthase activity
HBK86_RS15600	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HBK86_RS15630	COG0741	lytic transglycosylase activity
HBK86_RS15630	COG0739	heme binding
HBK86_RS15630	COG1196	nuclear chromosome segregation
HBK86_RS15640	COG1702	phosphate starvation-inducible protein PhoH
HBK86_RS15675	COG1295	ribonuclease BN
HBK86_RS15680	COG0697	spore germination
HBK86_RS15685	COG2169	Transcriptional regulator
HBK86_RS15690	COG0179	Fumarylacetoacetate (FAA) hydrolase
HBK86_RS15735	COG0557	exoribonuclease II activity
HBK86_RS15740	COG0339	signal peptide processing
HBK86_RS15745	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HBK86_RS15775	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HBK86_RS15780	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS15935	COG0626	cystathionine gamma-synthase activity
HBK86_RS15940	COG0433	COG0433 Predicted ATPase
HBK86_RS15950	COG1017	nitric oxide dioxygenase activity
HBK86_RS15950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HBK86_RS15955	COG1959	2 iron, 2 sulfur cluster binding
HBK86_RS15970	COG1301	dicarboxylic acid transport
HBK86_RS15975	COG1946	Acyl-CoA thioesterase
HBK86_RS15995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HBK86_RS16000	COG1040	competence protein
HBK86_RS16005	COG0494	nUDIX hydrolase
HBK86_RS16015	COG0598	Magnesium transport protein CorA
HBK86_RS16025	COG2854	intermembrane phospholipid transfer
HBK86_RS16035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HBK86_RS16040	COG1127	ABC transporter
HBK86_RS16050	COG0513	Belongs to the DEAD box helicase family
HBK86_RS16070	COG0408	coproporphyrinogen oxidase activity
HBK86_RS16085	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS16095	COG1983	PspC domain protein
HBK86_RS16100	COG0517	IMP dehydrogenase activity
HBK86_RS16135	COG1106	Psort location Cytoplasmic, score
HBK86_RS16155	COG0583	DNA-binding transcription factor activity
HBK86_RS16195	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS16205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HBK86_RS16210	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HBK86_RS16215	COG0833	amino acid
HBK86_RS16245	COG1192	Involved in chromosome partitioning
HBK86_RS16250	COG0628	permease
HBK86_RS16260	COG1289	transmembrane transporter activity
HBK86_RS16275	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBK86_RS16280	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HBK86_RS16290	COG0277	FAD linked oxidase domain protein
HBK86_RS16295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HBK86_RS16320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HBK86_RS16345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HBK86_RS16395	COG0194	GDP metabolic process
HBK86_RS16410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HBK86_RS16430	COG3307	-O-antigen
HBK86_RS16445	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HBK86_RS16450	COG1704	LemA family
HBK86_RS16460	COG0493	'glutamate synthase
HBK86_RS16465	COG0067	glutamate synthase
HBK86_RS16465	COG0070	glutamate synthase
HBK86_RS16465	COG0069	glutamate synthase activity
HBK86_RS16515	COG2226	methyltransferase
HBK86_RS16530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HBK86_RS16535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HBK86_RS16580	COG0833	amino acid
HBK86_RS16665	COG0488	(ABC) transporter
HBK86_RS16675	COG4221	oxidoreductase activity
HBK86_RS16680	COG0659	secondary active sulfate transmembrane transporter activity
HBK86_RS16690	COG0745	RESPONSE REGULATOR receiver
HBK86_RS16705	COG0427	acetyl-CoA hydrolase
HBK86_RS16735	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HBK86_RS16770	COG2329	Antibiotic biosynthesis monooxygenase
HBK86_RS16785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HBK86_RS16840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HBK86_RS16850	COG2249	NAD(P)H dehydrogenase (quinone) activity
HBK86_RS16855	COG1733	regulation of RNA biosynthetic process
HBK86_RS16870	COG1733	regulation of RNA biosynthetic process
HBK86_RS16890	COG0667	Aldo Keto reductase
HBK86_RS16910	COG0583	DNA-binding transcription factor activity
HBK86_RS16915	COG2814	Major facilitator Superfamily
HBK86_RS16945	COG1335	isochorismatase
HBK86_RS16955	COG1012	belongs to the aldehyde dehydrogenase family
HBK86_RS16960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HBK86_RS16970	COG1113	amino acid transport
HBK86_RS16980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HBK86_RS16995	COG2814	Major facilitator Superfamily
HBK86_RS17005	COG0351	phosphomethylpyrimidine kinase
HBK86_RS17005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HBK86_RS17005	COG0352	thiamine-phosphate diphosphorylase activity
HBK86_RS17025	COG1309	transcriptional regulator
HBK86_RS17030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HBK86_RS17035	COG3706	GGDEF domain
HBK86_RS17045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HBK86_RS17055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HBK86_RS17060	COG3162	membrane
HBK86_RS17065	COG2205	protein histidine kinase activity
HBK86_RS17065	COG2198	Histidine kinase
HBK86_RS17065	COG0784	Response regulator, receiver
HBK86_RS17090	COG1522	sequence-specific DNA binding
HBK86_RS17095	COG1335	isochorismatase
HBK86_RS17100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBK86_RS17110	COG0668	transmembrane transport
HBK86_RS17115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HBK86_RS17120	COG1519	Transferase
HBK86_RS17125	COG1902	pentaerythritol trinitrate reductase activity
HBK86_RS17150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HBK86_RS17175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HBK86_RS17175	COG0426	domain, Protein
HBK86_RS17180	COG4774	siderophore transport
HBK86_RS17185	COG2119	membrane
HBK86_RS17195	COG0508	dehydrogenase complex catalyzes the overall conversion of
HBK86_RS17205	COG4942	peptidase
HBK86_RS17220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HBK86_RS17230	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HBK86_RS17250	COG0189	ligase activity
HBK86_RS17280	COG0708	Exodeoxyribonuclease III
HBK86_RS17285	COG1393	Belongs to the ArsC family
HBK86_RS17300	COG3706	GGDEF domain
HBK86_RS17335	COG2351	hydroxyisourate hydrolase activity
HBK86_RS17340	COG2233	PERMEase
HBK86_RS17350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS17360	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HBK86_RS17365	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS17375	COG3150	esterase
HBK86_RS17420	COG3409	Peptidoglycan-binding domain 1 protein
HBK86_RS17420	COG5632	N-Acetylmuramoyl-L-alanine amidase
HBK86_RS17420	COG1388	LysM domain
HBK86_RS17425	COG3501	Rhs element vgr protein
HBK86_RS17435	COG2918	glutathione biosynthetic process
HBK86_RS17450	COG2733	membrane
HBK86_RS17455	COG0436	Aminotransferase
HBK86_RS17460	COG0534	Mate efflux family protein
HBK86_RS17545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HBK86_RS17550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HBK86_RS17560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HBK86_RS17605	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HBK86_RS17655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBK86_RS17660	COG0546	phosphoglycolate phosphatase activity
HBK86_RS17670	COG0010	Belongs to the arginase family
HBK86_RS17700	COG2188	Transcriptional regulator
HBK86_RS17710	COG0523	cobalamin synthesis protein
HBK86_RS17720	COG1113	amino acid transport
HBK86_RS17730	COG0625	glutathione transferase activity
HBK86_RS17750	COG1683	Conserved Protein
HBK86_RS17755	COG0534	Mate efflux family protein
HBK86_RS17760	COG0385	Bile acid
HBK86_RS17765	COG1335	isochorismatase
HBK86_RS17770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBK86_RS17790	COG2116	formate transmembrane transporter activity
HBK86_RS17795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HBK86_RS17800	COG2133	pyrroloquinoline quinone binding
HBK86_RS17805	COG2983	Belongs to the UPF0260 family
HBK86_RS17825	COG1194	a g-specific adenine glycosylase
HBK86_RS17840	COG2818	Glycosylase
HBK86_RS17845	COG1064	alcohol dehydrogenase
HBK86_RS17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBK86_RS17865	COG0583	DNA-binding transcription factor activity
HBK86_RS17870	COG0656	L-ascorbic acid biosynthetic process
HBK86_RS17875	COG2814	Major facilitator Superfamily
HBK86_RS17910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HBK86_RS17925	COG2233	PERMEase
HBK86_RS17930	COG0583	DNA-binding transcription factor activity
HBK86_RS17965	COG0733	neurotransmitter:sodium symporter activity
HBK86_RS18005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HBK86_RS18010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HBK86_RS18015	COG0596	Alpha beta hydrolase
HBK86_RS18040	COG0488	(ABC) transporter
HBK86_RS18045	COG0586	Pfam SNARE associated Golgi protein
HBK86_RS18055	COG0187	DNA topoisomerase II activity
HBK86_RS18065	COG0592	DNA-directed DNA polymerase activity
HBK86_RS18090	COG0706	membrane insertase activity
HBK86_RS18105	COG1230	cation diffusion facilitator family transporter
HBK86_RS18110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBK86_RS18125	COG0402	S-adenosylhomocysteine deaminase activity
HBK86_RS18135	COG0754	glutathionylspermidine amidase activity
HBK86_RS18145	COG0861	Integral membrane protein TerC family
HBK86_RS18150	COG0671	phosphoesterase, PA-phosphatase related
HBK86_RS18160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HBK86_RS18175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HBK86_RS18180	COG2951	lytic endotransglycosylase activity
HBK86_RS18235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HBK86_RS18275	COG1047	Peptidyl-prolyl cis-trans
HBK86_RS18285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HBK86_RS18290	COG0196	riboflavin kinase activity
HBK86_RS18300	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HBK86_RS18305	COG1309	transcriptional regulator
HBK86_RS18310	COG1116	anion transmembrane transporter activity
HBK86_RS18315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HBK86_RS18320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HBK86_RS18325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBK86_RS18330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HBK86_RS18350	COG1028	Short-chain dehydrogenase reductase Sdr
HBK86_RS18355	COG0546	phosphoglycolate phosphatase activity
HBK86_RS18410	COG3023	N-Acetylmuramoyl-L-alanine amidase
HBK86_RS18415	COG0728	peptidoglycan biosynthetic process
HBK86_RS18440	COG1596	polysaccharide export
HBK86_RS18445	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HBK86_RS18475	COG0438	transferase activity, transferring glycosyl groups
HBK86_RS18500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HBK86_RS18505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HBK86_RS18520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HBK86_RS18525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBK86_RS18535	COG2186	Transcriptional regulator
HBK86_RS18545	COG0277	FAD linked oxidase domain protein
HBK86_RS18550	COG1448	Aminotransferase
HBK86_RS18555	COG1802	Transcriptional regulator
HBK86_RS18570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HBK86_RS18665	COG0564	pseudouridine synthase activity
HBK86_RS18705	COG0251	oxidation-reduction process
HBK86_RS18710	COG1113	amino acid transport
HBK86_RS18715	COG1113	amino acid transport
HBK86_RS18735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HBK86_RS18740	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS18745	COG1024	Enoyl-CoA hydratase
HBK86_RS18750	COG1024	Enoyl-CoA hydratase
HBK86_RS18755	COG0477	Major facilitator Superfamily
HBK86_RS18760	COG3916	Acyl-homoserine-lactone synthase
HBK86_RS18770	COG2197	response regulator
HBK86_RS18780	COG1960	acyl-CoA dehydrogenase activity
HBK86_RS18785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HBK86_RS18785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HBK86_RS18785	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HBK86_RS18785	COG3321	synthase
HBK86_RS18825	COG0271	Belongs to the BolA IbaG family
HBK86_RS18835	COG1192	Involved in chromosome partitioning
HBK86_RS18850	COG0586	Pfam SNARE associated Golgi protein
HBK86_RS18855	COG2259	Doxx family
HBK86_RS18860	COG4399	Belongs to the UPF0754 family
HBK86_RS18865	COG0519	Catalyzes the synthesis of GMP from XMP
HBK86_RS18865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HBK86_RS18910	COG0281	malic enzyme
HBK86_RS18915	COG2837	iron assimilation
HBK86_RS18920	COG1280	lysine exporter protein (LysE YggA)
HBK86_RS18925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HBK86_RS18930	COG1121	(ABC) transporter
HBK86_RS18995	COG0386	Belongs to the glutathione peroxidase family
HBK86_RS19010	COG1309	transcriptional regulator
HBK86_RS19015	COG0697	spore germination
HBK86_RS19025	COG0758	DNA mediated transformation
HBK86_RS19060	COG1309	transcriptional regulator
HBK86_RS19095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HBK86_RS19105	COG0655	NAD(P)H dehydrogenase (quinone) activity
HBK86_RS19145	COG4452	Inner membrane protein CreD
HBK86_RS19150	COG2205	protein histidine kinase activity
HBK86_RS19155	COG0745	RESPONSE REGULATOR receiver
HBK86_RS19160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBK86_RS19170	COG0477	Major facilitator Superfamily
HBK86_RS19180	COG1253	flavin adenine dinucleotide binding
HBK86_RS19185	COG3012	SEC-C Motif Domain Protein
HBK86_RS19190	COG2860	membrane
HBK86_RS19195	COG0477	Major facilitator Superfamily
HBK86_RS19205	COG0318	PFAM AMP-dependent synthetase and ligase
HBK86_RS19220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HBK86_RS19235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HBK86_RS19245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HBK86_RS19250	COG0606	chelatase, subunit chli
HBK86_RS19290	COG0589	response to stress
HBK86_RS19295	COG0659	secondary active sulfate transmembrane transporter activity
HBK86_RS19310	COG1061	Type III restriction enzyme res subunit
HBK86_RS19335	COG0606	chelatase, subunit chli
HBK86_RS19345	COG0347	Belongs to the P(II) protein family
HBK86_RS19350	COG0004	ammonium transporteR
HBK86_RS19360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBK86_RS19360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HBK86_RS19400	COG0795	lipopolysaccharide-transporting ATPase activity
HBK86_RS19405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HBK86_RS19410	COG0793	Belongs to the peptidase S41A family
HBK86_RS19425	COG2197	response regulator
HBK86_RS19435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HBK86_RS19445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HBK86_RS19450	COG4974	Belongs to the 'phage' integrase family
HBK86_RS19475	COG0772	Belongs to the SEDS family
HBK86_RS19480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HBK86_RS19485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HBK86_RS19490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HBK86_RS19515	COG0697	spore germination
HBK86_RS19520	COG1538	Outer membrane efflux protein
HBK86_RS19540	COG3275	phosphorelay sensor kinase activity
HBK86_RS19550	COG0181	hydroxymethylbilane synthase activity
HBK86_RS19595	COG1716	ATPase activity
HBK86_RS19600	COG0546	phosphoglycolate phosphatase activity
HBK86_RS19700	COG2056	Na+-H+ antiporter family
HBK86_RS19715	COG0326	Molecular chaperone. Has ATPase activity
HBK86_RS19730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HBK86_RS19795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HBK86_RS19800	COG2169	Transcriptional regulator
HBK86_RS19800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HBK86_RS19830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HBK86_RS19840	COG0497	DNA recombination
HBK86_RS19855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HBK86_RS19865	COG0237	dephospho-CoA kinase activity
HBK86_RS19915	COG0195	Participates in both transcription termination and antitermination
HBK86_RS19935	COG2212	antiporter activity
HBK86_RS19945	COG0651	ATP synthesis coupled electron transport
HBK86_RS19950	COG1006	Multisubunit Na H antiporter MnhC subunit
HBK86_RS19955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HBK86_RS19955	COG2111	Na H antiporter
HBK86_RS19970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HBK86_RS19985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HBK86_RS20000	COG2226	methyltransferase
HBK86_RS20020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HBK86_RS20025	COG1074	ATP-dependent DNA helicase activity
HBK86_RS20030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HBK86_RS20050	COG0598	Magnesium transport protein CorA
HBK86_RS20055	COG0789	Transcriptional regulator
HBK86_RS20060	COG0484	heat shock protein binding
HBK86_RS20075	COG0475	glutathione-regulated potassium exporter activity
HBK86_RS20075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HBK86_RS20080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HBK86_RS20100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HBK86_RS20110	COG4535	Mg2 and Co2 transporter CorC
HBK86_RS20115	COG0425	Belongs to the sulfur carrier protein TusA family
HBK86_RS20125	COG0644	oxidoreductase
HBK86_RS20125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HBK86_RS20135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HBK86_RS20150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HBK86_RS20155	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HBK86_RS20195	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HBK86_RS20210	COG0534	Mate efflux family protein
HBK86_RS20220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HBK86_RS20225	COG4221	oxidoreductase activity
HBK86_RS20230	COG0583	DNA-binding transcription factor activity
HBK86_RS20245	COG0318	PFAM AMP-dependent synthetase and ligase
HBK86_RS20250	COG1530	ribonuclease E activity
HBK86_RS20265	COG0546	phosphoglycolate phosphatase activity
HBK86_RS20270	COG2378	regulation of single-species biofilm formation
HBK86_RS20275	COG0625	glutathione transferase activity
HBK86_RS20285	COG0583	DNA-binding transcription factor activity
HBK86_RS20340	COG0473	3-isopropylmalate dehydrogenase activity
HBK86_RS20405	COG0501	Belongs to the peptidase M48B family
HBK86_RS20585	COG0739	heme binding
HBK86_RS20615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HBK86_RS20630	COG1192	Involved in chromosome partitioning
HBK86_RS20680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HBK86_RS20785	COG1373	ATPase (AAA superfamily
HBK86_RS20845	COG0659	secondary active sulfate transmembrane transporter activity
HBK86_RS20850	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HBK86_RS20955	COG1061	Type III restriction enzyme res subunit
HBK86_RS21100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HBK86_RS21145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBK86_RS21170	COG1192	Involved in chromosome partitioning
HBK86_RS21270	COG0589	response to stress
HBK86_RS21275	COG0659	secondary active sulfate transmembrane transporter activity
HBK86_RS21305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HBK86_RS21355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HBK86_RS21420	COG3173	Aminoglycoside phosphotransferase
HBK86_RS21440	COG0482	sulfurtransferase activity
HBK86_RS21565	COG4683	PFAM Phage derived protein Gp49-like (DUF891)