locus-tag	class	description
C6N18_RS00055	COG1525	nuclease
C6N18_RS00125	COG1475	DNA binding
C6N18_RS00145	COG3853	Toxic anion resistance protein (TelA)
C6N18_RS00335	COG0741	lytic transglycosylase activity
C6N18_RS00370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6N18_RS00630	COG0582	viral genome integration into host DNA
C6N18_RS00660	COG1660	Displays ATPase and GTPase activities
C6N18_RS00730	COG0745	RESPONSE REGULATOR receiver
C6N18_RS00750	COG3657	addiction module killer protein
C6N18_RS00755	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N18_RS00775	COG0488	(ABC) transporter
C6N18_RS00780	COG3173	Aminoglycoside phosphotransferase
C6N18_RS00815	COG0583	DNA-binding transcription factor activity
C6N18_RS00860	COG1475	DNA binding
C6N18_RS00865	COG1192	Involved in chromosome partitioning
C6N18_RS00875	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C6N18_RS00890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C6N18_RS00935	COG0592	DNA-directed DNA polymerase activity
C6N18_RS00945	COG0187	DNA topoisomerase II activity
C6N18_RS00955	COG0586	Pfam SNARE associated Golgi protein
C6N18_RS00960	COG0488	(ABC) transporter
C6N18_RS00985	COG0596	Alpha beta hydrolase
C6N18_RS00990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6N18_RS00995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6N18_RS01040	COG0733	neurotransmitter:sodium symporter activity
C6N18_RS01075	COG0583	DNA-binding transcription factor activity
C6N18_RS01080	COG2233	PERMEase
C6N18_RS01095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS01130	COG2814	Major facilitator Superfamily
C6N18_RS01135	COG0656	L-ascorbic acid biosynthetic process
C6N18_RS01140	COG0583	DNA-binding transcription factor activity
C6N18_RS01155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6N18_RS01160	COG1064	alcohol dehydrogenase
C6N18_RS01165	COG2818	Glycosylase
C6N18_RS01180	COG1194	a g-specific adenine glycosylase
C6N18_RS01200	COG2983	Belongs to the UPF0260 family
C6N18_RS01205	COG2133	pyrroloquinoline quinone binding
C6N18_RS01210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6N18_RS01215	COG2116	formate transmembrane transporter activity
C6N18_RS01235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6N18_RS01240	COG1335	isochorismatase
C6N18_RS01245	COG0385	Bile acid
C6N18_RS01250	COG0534	Mate efflux family protein
C6N18_RS01255	COG1683	Conserved Protein
C6N18_RS01275	COG0625	glutathione transferase activity
C6N18_RS01285	COG1113	amino acid transport
C6N18_RS01295	COG0523	cobalamin synthesis protein
C6N18_RS01305	COG2188	Transcriptional regulator
C6N18_RS01335	COG0010	Belongs to the arginase family
C6N18_RS01350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6N18_RS01385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6N18_RS01395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6N18_RS01400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C6N18_RS01490	COG0534	Mate efflux family protein
C6N18_RS01495	COG0436	Aminotransferase
C6N18_RS01500	COG2733	membrane
C6N18_RS01515	COG2918	glutathione biosynthetic process
C6N18_RS01530	COG1388	LysM domain
C6N18_RS01530	COG5632	N-Acetylmuramoyl-L-alanine amidase
C6N18_RS01530	COG3409	Peptidoglycan-binding domain 1 protein
C6N18_RS01560	COG3150	esterase
C6N18_RS01570	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C6N18_RS01580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6N18_RS01590	COG2233	PERMEase
C6N18_RS01595	COG2351	hydroxyisourate hydrolase activity
C6N18_RS01630	COG3706	GGDEF domain
C6N18_RS01645	COG1393	Belongs to the ArsC family
C6N18_RS01650	COG0708	Exodeoxyribonuclease III
C6N18_RS01670	COG0189	ligase activity
C6N18_RS01690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6N18_RS01700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6N18_RS01715	COG4942	peptidase
C6N18_RS01725	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6N18_RS01735	COG2119	membrane
C6N18_RS01740	COG4774	siderophore transport
C6N18_RS01745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS01745	COG0426	domain, Protein
C6N18_RS01770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6N18_RS01790	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS01795	COG1519	Transferase
C6N18_RS01800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6N18_RS01805	COG0668	transmembrane transport
C6N18_RS01815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6N18_RS01820	COG1335	isochorismatase
C6N18_RS01825	COG1522	sequence-specific DNA binding
C6N18_RS01850	COG2205	protein histidine kinase activity
C6N18_RS01850	COG0784	Response regulator, receiver
C6N18_RS01850	COG2198	Histidine kinase
C6N18_RS01855	COG3162	membrane
C6N18_RS01860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6N18_RS01870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6N18_RS01920	COG0789	Transcriptional regulator
C6N18_RS01950	COG0659	secondary active sulfate transmembrane transporter activity
C6N18_RS01960	COG0606	chelatase, subunit chli
C6N18_RS01970	COG0347	Belongs to the P(II) protein family
C6N18_RS01975	COG0004	ammonium transporteR
C6N18_RS01985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6N18_RS01985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6N18_RS02025	COG0795	lipopolysaccharide-transporting ATPase activity
C6N18_RS02030	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C6N18_RS02035	COG0793	Belongs to the peptidase S41A family
C6N18_RS02050	COG2197	response regulator
C6N18_RS02060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6N18_RS02070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6N18_RS02075	COG4974	Belongs to the 'phage' integrase family
C6N18_RS02100	COG0772	Belongs to the SEDS family
C6N18_RS02105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6N18_RS02110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6N18_RS02115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6N18_RS02140	COG0697	spore germination
C6N18_RS02145	COG1538	Outer membrane efflux protein
C6N18_RS02165	COG3275	phosphorelay sensor kinase activity
C6N18_RS02175	COG0181	hydroxymethylbilane synthase activity
C6N18_RS02220	COG1716	ATPase activity
C6N18_RS02225	COG0546	phosphoglycolate phosphatase activity
C6N18_RS02325	COG2056	Na+-H+ antiporter family
C6N18_RS02340	COG0326	Molecular chaperone. Has ATPase activity
C6N18_RS02355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C6N18_RS02415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6N18_RS02420	COG2169	Transcriptional regulator
C6N18_RS02420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6N18_RS02450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C6N18_RS02460	COG0497	DNA recombination
C6N18_RS02475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6N18_RS02485	COG0237	dephospho-CoA kinase activity
C6N18_RS02535	COG0195	Participates in both transcription termination and antitermination
C6N18_RS02550	COG1320	monovalent cation:proton antiporter activity
C6N18_RS02555	COG2212	antiporter activity
C6N18_RS02560	COG1863	multisubunit Na H antiporter MnhE subunit
C6N18_RS02565	COG0651	ATP synthesis coupled electron transport
C6N18_RS02570	COG1006	Multisubunit Na H antiporter MnhC subunit
C6N18_RS02575	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6N18_RS02575	COG2111	Na H antiporter
C6N18_RS02590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6N18_RS02595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6N18_RS02610	COG2226	methyltransferase
C6N18_RS02630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6N18_RS02635	COG1074	ATP-dependent DNA helicase activity
C6N18_RS02640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N18_RS02645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6N18_RS02660	COG0598	Magnesium transport protein CorA
C6N18_RS02665	COG0789	Transcriptional regulator
C6N18_RS02670	COG0484	heat shock protein binding
C6N18_RS02685	COG0475	glutathione-regulated potassium exporter activity
C6N18_RS02685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6N18_RS02690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6N18_RS02710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N18_RS02720	COG4535	Mg2 and Co2 transporter CorC
C6N18_RS02725	COG0425	Belongs to the sulfur carrier protein TusA family
C6N18_RS02735	COG0644	oxidoreductase
C6N18_RS02735	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C6N18_RS02745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6N18_RS02760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6N18_RS02765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C6N18_RS02775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6N18_RS02775	COG0493	'glutamate synthase
C6N18_RS02800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6N18_RS02815	COG0534	Mate efflux family protein
C6N18_RS02825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6N18_RS02830	COG4221	oxidoreductase activity
C6N18_RS02835	COG0583	DNA-binding transcription factor activity
C6N18_RS02850	COG0318	PFAM AMP-dependent synthetase and ligase
C6N18_RS02855	COG1530	ribonuclease E activity
C6N18_RS02870	COG0546	phosphoglycolate phosphatase activity
C6N18_RS02875	COG2378	regulation of single-species biofilm formation
C6N18_RS02880	COG0625	glutathione transferase activity
C6N18_RS02890	COG0583	DNA-binding transcription factor activity
C6N18_RS02945	COG0473	3-isopropylmalate dehydrogenase activity
C6N18_RS03000	COG1301	dicarboxylic acid transport
C6N18_RS03010	COG1560	Kdo2-lipid A biosynthetic process
C6N18_RS03015	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS03020	COG0488	(ABC) transporter
C6N18_RS03025	COG2900	Belongs to the SlyX family
C6N18_RS03035	COG1733	regulation of RNA biosynthetic process
C6N18_RS03060	COG0210	DNA helicase
C6N18_RS03065	COG0724	RNA recognition motif
C6N18_RS03085	COG4651	solute:proton antiporter activity
C6N18_RS03085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6N18_RS03110	COG0788	formyltetrahydrofolate deformylase activity
C6N18_RS03210	COG2813	Specifically methylates the guanine in position
C6N18_RS03210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6N18_RS03220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6N18_RS03230	COG4774	siderophore transport
C6N18_RS03240	COG0740	serine-type endopeptidase activity
C6N18_RS03260	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6N18_RS03260	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6N18_RS03265	COG0857	belongs to the CobB CobQ family
C6N18_RS03265	COG0280	phosphate acetyltransferase
C6N18_RS03270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6N18_RS03285	COG0800	Aldolase
C6N18_RS03295	COG3265	gluconokinase activity
C6N18_RS03300	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS03310	COG2267	carboxylic ester hydrolase activity
C6N18_RS03325	COG0793	Belongs to the peptidase S41A family
C6N18_RS03360	COG1426	Protein conserved in bacteria
C6N18_RS03400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6N18_RS03410	COG1162	GTPase activity
C6N18_RS03415	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C6N18_RS03430	COG1538	Outer membrane efflux protein
C6N18_RS03435	COG1136	(ABC) transporter
C6N18_RS03435	COG0577	efflux transmembrane transporter activity
C6N18_RS03440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS03465	COG0028	Belongs to the TPP enzyme family
C6N18_RS03470	COG0440	acetolactate synthase activity
C6N18_RS03515	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6N18_RS03530	COG0084	hydrolase, TatD family'
C6N18_RS03540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C6N18_RS03550	COG0583	DNA-binding transcription factor activity
C6N18_RS03560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6N18_RS03650	COG2205	protein histidine kinase activity
C6N18_RS03665	COG2132	Multicopper oxidase
C6N18_RS03685	COG2814	Major facilitator Superfamily
C6N18_RS03695	COG0697	spore germination
C6N18_RS03725	COG3622	Belongs to the hyi family
C6N18_RS03730	COG2084	Dehydrogenase
C6N18_RS03735	COG1024	Enoyl-CoA hydratase
C6N18_RS03740	COG0784	Response regulator, receiver
C6N18_RS03740	COG2205	protein histidine kinase activity
C6N18_RS03740	COG5002	protein histidine kinase activity
C6N18_RS03760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6N18_RS03770	COG3956	TIGRFAM MazG family protein
C6N18_RS03775	COG1555	photosystem II stabilization
C6N18_RS03780	COG0617	tRNA 3'-terminal CCA addition
C6N18_RS03785	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6N18_RS03805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6N18_RS03810	COG3028	Belongs to the UPF0307 family
C6N18_RS03815	COG0318	PFAM AMP-dependent synthetase and ligase
C6N18_RS03830	COG0625	glutathione transferase activity
C6N18_RS03835	COG1238	metal cluster binding
C6N18_RS03870	COG0072	phenylalanine-tRNA ligase activity
C6N18_RS03900	COG0248	Ppx GppA phosphatase
C6N18_RS03910	COG0037	tRNA processing
C6N18_RS03950	COG1764	response to oxidative stress
C6N18_RS03955	COG1846	Transcriptional regulator
C6N18_RS03965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6N18_RS04025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6N18_RS04030	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6N18_RS04035	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6N18_RS04045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6N18_RS04095	COG1214	PFAM Peptidase M22, glycoprotease
C6N18_RS04110	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6N18_RS04120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6N18_RS04125	COG0561	phosphatase activity
C6N18_RS04135	COG2132	Multicopper oxidase
C6N18_RS04140	COG3667	copper resistance
C6N18_RS04155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6N18_RS04160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6N18_RS04165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6N18_RS04195	COG1063	alcohol dehydrogenase
C6N18_RS04200	COG0583	DNA-binding transcription factor activity
C6N18_RS04205	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS04210	COG2814	Major facilitator Superfamily
C6N18_RS04215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6N18_RS04225	COG1053	succinate dehydrogenase
C6N18_RS04230	COG0583	DNA-binding transcription factor activity
C6N18_RS04250	COG0583	DNA-binding transcription factor activity
C6N18_RS04280	COG0583	DNA-binding transcription factor activity
C6N18_RS04295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS04305	COG1309	transcriptional regulator
C6N18_RS04335	COG0384	phenazine biosynthesis protein PhzF
C6N18_RS04345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6N18_RS04365	COG0745	RESPONSE REGULATOR receiver
C6N18_RS04405	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6N18_RS04435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6N18_RS04440	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6N18_RS04465	COG0583	DNA-binding transcription factor activity
C6N18_RS04485	COG0668	transmembrane transport
C6N18_RS04495	COG2081	HI0933 family
C6N18_RS04500	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C6N18_RS04530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N18_RS04530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6N18_RS04540	COG0489	protein tyrosine kinase activity
C6N18_RS04600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6N18_RS04610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6N18_RS04625	COG0730	response to heat
C6N18_RS04635	COG1196	nuclear chromosome segregation
C6N18_RS04655	COG2223	nitrite transmembrane transporter activity
C6N18_RS04660	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6N18_RS04665	COG1877	trehalose-phosphatase activity
C6N18_RS04670	COG0596	Alpha beta hydrolase
C6N18_RS04670	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6N18_RS04670	COG2226	methyltransferase
C6N18_RS04685	COG4106	trans-aconitate 2-methyltransferase activity
C6N18_RS04700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6N18_RS04705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C6N18_RS04710	COG0009	L-threonylcarbamoyladenylate synthase
C6N18_RS04715	COG3101	peptidyl-lysine hydroxylation
C6N18_RS04720	COG1399	metal-binding, possibly nucleic acid-binding protein
C6N18_RS04745	COG1652	LysM domain
C6N18_RS04750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C6N18_RS04750	COG0351	phosphomethylpyrimidine kinase
C6N18_RS04750	COG0352	thiamine-phosphate diphosphorylase activity
C6N18_RS04760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6N18_RS04790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6N18_RS04820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C6N18_RS04835	COG0358	DNA primase activity
C6N18_RS04845	COG0564	pseudouridine synthase activity
C6N18_RS04870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6N18_RS04890	COG0583	DNA-binding transcription factor activity
C6N18_RS04895	COG0473	3-isopropylmalate dehydrogenase activity
C6N18_RS04905	COG0657	acetylesterase activity
C6N18_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS04935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6N18_RS04935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6N18_RS04950	COG1981	membrane
C6N18_RS04995	COG0456	acetyltransferase
C6N18_RS05005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6N18_RS05010	COG0492	ferredoxin-NADP+ reductase activity
C6N18_RS05015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6N18_RS05015	COG1674	ftsk spoiiie
C6N18_RS05020	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS05035	COG2894	cell division
C6N18_RS05050	COG0204	Acyl-transferase
C6N18_RS05055	COG2885	chlorophyll binding
C6N18_RS05060	COG0210	DNA helicase
C6N18_RS05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6N18_RS05085	COG0121	glutamine amidotransferase
C6N18_RS05110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6N18_RS05115	COG0735	belongs to the Fur family
C6N18_RS05140	COG0420	3'-5' exonuclease activity
C6N18_RS05160	COG1090	epimerase
C6N18_RS05175	COG2050	protein possibly involved in aromatic compounds catabolism
C6N18_RS05185	COG2814	Major facilitator Superfamily
C6N18_RS05190	COG0405	Gamma-glutamyltransferase
C6N18_RS05200	COG0582	viral genome integration into host DNA
C6N18_RS05290	COG0084	hydrolase, TatD family'
C6N18_RS05310	COG0477	Major facilitator Superfamily
C6N18_RS05315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6N18_RS05325	COG1595	DNA-templated transcription, initiation
C6N18_RS05380	COG0531	amino acid
C6N18_RS05385	COG2040	homocysteine
C6N18_RS05410	COG1309	transcriptional regulator
C6N18_RS05415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6N18_RS05420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6N18_RS05430	COG1607	acyl-coa hydrolase
C6N18_RS05440	COG0523	cobalamin synthesis protein
C6N18_RS05450	COG4681	YaeQ
C6N18_RS05460	COG1649	PFAM Uncharacterised BCR, COG1649
C6N18_RS05460	COG0726	polysaccharide deacetylase
C6N18_RS05465	COG1215	transferase activity, transferring glycosyl groups
C6N18_RS05475	COG1024	Enoyl-CoA hydratase
C6N18_RS05490	COG1414	Transcriptional regulator
C6N18_RS05510	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS05520	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N18_RS05525	COG2271	Major facilitator Superfamily
C6N18_RS05535	COG2267	carboxylic ester hydrolase activity
C6N18_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS05555	COG0028	Belongs to the TPP enzyme family
C6N18_RS05565	COG0477	Major facilitator Superfamily
C6N18_RS05570	COG0242	peptide deformylase activity
C6N18_RS05575	COG2066	Belongs to the glutaminase family
C6N18_RS05580	COG2207	Transcriptional regulator
C6N18_RS05585	COG2223	nitrite transmembrane transporter activity
C6N18_RS05605	COG0583	DNA-binding transcription factor activity
C6N18_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS05615	COG2271	Major facilitator Superfamily
C6N18_RS05620	COG3959	Transketolase, thiamine diphosphate binding domain
C6N18_RS05625	COG3958	Transketolase
C6N18_RS05635	COG0306	phosphate transporter
C6N18_RS05655	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6N18_RS05700	COG4181	ATPase activity
C6N18_RS05705	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C6N18_RS05735	COG0583	DNA-binding transcription factor activity
C6N18_RS05745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6N18_RS05750	COG1773	rubredoxin
C6N18_RS05800	COG2851	Citrate transporter
C6N18_RS05810	COG1253	flavin adenine dinucleotide binding
C6N18_RS05850	COG0804	urea catabolic process
C6N18_RS05860	COG0830	nickel cation binding
C6N18_RS05875	COG0742	ribosomal rna small subunit methyltransferase
C6N18_RS05880	COG0768	penicillin binding
C6N18_RS05905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6N18_RS05910	COG2878	Part of a membrane complex involved in electron transport
C6N18_RS05915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6N18_RS05925	COG3384	dioxygenase
C6N18_RS05945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6N18_RS05985	COG0006	proline dipeptidase activity
C6N18_RS05990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6N18_RS05995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6N18_RS06015	COG1279	arginine transmembrane transporter activity
C6N18_RS06020	COG0583	DNA-binding transcription factor activity
C6N18_RS06060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6N18_RS06065	COG1388	LysM domain
C6N18_RS06065	COG0741	lytic transglycosylase activity
C6N18_RS06065	COG0741	lytic transglycosylase activity
C6N18_RS06065	COG1388	LysM domain
C6N18_RS06075	COG4174	ABC transporter (Permease)
C6N18_RS06080	COG4239	(ABC) transporter, permease
C6N18_RS06085	COG4172	Belongs to the ABC transporter superfamily
C6N18_RS06140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6N18_RS06150	COG4251	negative regulation of phosphorylation
C6N18_RS06150	COG3706	GGDEF domain
C6N18_RS06150	COG2203	Gaf domain
C6N18_RS06150	COG5001	Diguanylate cyclase
C6N18_RS06160	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N18_RS06160	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS06195	COG3209	COG3209 Rhs family protein
C6N18_RS06235	COG1113	amino acid transport
C6N18_RS06245	COG0531	amino acid
C6N18_RS06265	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS06285	COG1113	amino acid transport
C6N18_RS06315	COG0697	spore germination
C6N18_RS06320	COG2721	sulfolactate sulfo-lyase activity
C6N18_RS06325	COG2271	Major facilitator Superfamily
C6N18_RS06330	COG4948	Mandelate Racemase Muconate Lactonizing
C6N18_RS06340	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS06345	COG2186	Transcriptional regulator
C6N18_RS06370	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS06380	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS06385	COG1024	Enoyl-CoA hydratase
C6N18_RS06390	COG2814	Major facilitator Superfamily
C6N18_RS06405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6N18_RS06450	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C6N18_RS06455	COG2072	flavoprotein involved in K transport
C6N18_RS06460	COG0300	oxidoreductase activity
C6N18_RS06470	COG1309	transcriptional regulator
C6N18_RS06475	COG1741	Belongs to the pirin family
C6N18_RS06490	COG2072	flavoprotein involved in K transport
C6N18_RS06500	COG2252	PERMEase
C6N18_RS06505	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6N18_RS06510	COG3038	cytochrome b561
C6N18_RS06520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6N18_RS06530	COG0527	aspartate kinase activity
C6N18_RS06540	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6N18_RS06550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6N18_RS06565	COG0667	Aldo Keto reductase
C6N18_RS06575	COG1765	OsmC-like protein
C6N18_RS06590	COG0542	response to heat
C6N18_RS06625	COG2885	chlorophyll binding
C6N18_RS06635	COG0625	glutathione transferase activity
C6N18_RS06640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6N18_RS06660	COG3634	alkyl hydroperoxide reductase activity
C6N18_RS06670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6N18_RS06680	COG0450	alkyl hydroperoxide reductase
C6N18_RS06685	COG1643	Atp-dependent helicase
C6N18_RS06700	COG2814	Major facilitator Superfamily
C6N18_RS06705	COG3135	benzoate transporter
C6N18_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS06715	COG0633	Ferredoxin
C6N18_RS06715	COG0543	2 iron, 2 sulfur cluster binding
C6N18_RS06720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C6N18_RS06725	COG4638	Rieske (2fe-2S)
C6N18_RS06730	COG0583	DNA-binding transcription factor activity
C6N18_RS06785	COG1570	exodeoxyribonuclease VII activity
C6N18_RS06820	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS06825	COG1278	Cold shock
C6N18_RS06865	COG2814	Major facilitator Superfamily
C6N18_RS06940	COG5410	chromosome segregation
C6N18_RS06945	COG3567	Phage-associated protein, HI1409 family
C6N18_RS06965	COG3566	protein conserved in bacteria
C6N18_RS06985	COG5434	Belongs to the glycosyl hydrolase 28 family
C6N18_RS07045	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C6N18_RS07055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C6N18_RS07060	COG1137	ATPase activity
C6N18_RS07065	COG1538	Outer membrane efflux protein
C6N18_RS07095	COG4122	O-methyltransferase activity
C6N18_RS07105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C6N18_RS07120	COG1522	sequence-specific DNA binding
C6N18_RS07125	COG5006	permease, DMT superfamily
C6N18_RS07135	COG1560	Kdo2-lipid A biosynthetic process
C6N18_RS07150	COG2814	Major facilitator Superfamily
C6N18_RS07170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6N18_RS07220	COG3209	COG3209 Rhs family protein
C6N18_RS07240	COG0583	DNA-binding transcription factor activity
C6N18_RS07245	COG1914	H( )-stimulated, divalent metal cation uptake system
C6N18_RS07265	COG4770	biotin carboxylase activity
C6N18_RS07270	COG0038	chloride channel
C6N18_RS07300	COG1309	transcriptional regulator
C6N18_RS07310	COG1063	alcohol dehydrogenase
C6N18_RS07325	COG0439	Biotin carboxylase
C6N18_RS07330	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6N18_RS07335	COG1733	regulation of RNA biosynthetic process
C6N18_RS07345	COG0864	Transcriptional regulator
C6N18_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N18_RS07360	COG1116	anion transmembrane transporter activity
C6N18_RS07480	COG0590	tRNA wobble adenosine to inosine editing
C6N18_RS07485	COG2807	transmembrane transport
C6N18_RS07500	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C6N18_RS07510	COG0789	Transcriptional regulator
C6N18_RS07525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6N18_RS07545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6N18_RS07570	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS07575	COG0531	amino acid
C6N18_RS07580	COG1760	l-serine dehydratase
C6N18_RS07585	COG2030	dehydratase
C6N18_RS07585	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS07590	COG3396	Phenylacetate-CoA oxygenase
C6N18_RS07595	COG3460	Phenylacetate-CoA oxygenase
C6N18_RS07600	COG3396	Phenylacetate-CoA oxygenase
C6N18_RS07605	COG2151	metal-sulfur cluster biosynthetic enzyme
C6N18_RS07610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6N18_RS07615	COG1024	Enoyl-CoA hydratase
C6N18_RS07620	COG1024	Enoyl-CoA hydratase
C6N18_RS07625	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6N18_RS07630	COG0183	Belongs to the thiolase family
C6N18_RS07635	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C6N18_RS07640	COG3327	negative regulation of DNA-templated transcription, initiation
C6N18_RS07650	COG2050	protein possibly involved in aromatic compounds catabolism
C6N18_RS07655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6N18_RS07660	COG0210	DNA helicase
C6N18_RS07710	COG1278	Cold shock
C6N18_RS07740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6N18_RS07745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6N18_RS07750	COG2271	Major facilitator Superfamily
C6N18_RS07755	COG0753	catalase activity
C6N18_RS07760	COG3038	cytochrome b561
C6N18_RS07780	COG2267	carboxylic ester hydrolase activity
C6N18_RS07785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS07790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6N18_RS07795	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS07805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6N18_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS07820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6N18_RS07825	COG0583	DNA-binding transcription factor activity
C6N18_RS07835	COG1414	Transcriptional regulator
C6N18_RS07840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6N18_RS07850	COG1840	ABC-type Fe3 transport system, periplasmic component
C6N18_RS07855	COG3842	ATPase activity
C6N18_RS07870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C6N18_RS07875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6N18_RS07880	COG2814	Major facilitator Superfamily
C6N18_RS07885	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS07890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6N18_RS07900	COG1024	Enoyl-CoA hydratase
C6N18_RS07910	COG2814	Major facilitator Superfamily
C6N18_RS07920	COG0183	Belongs to the thiolase family
C6N18_RS07925	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6N18_RS07930	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS07935	COG1024	Enoyl-CoA hydratase
C6N18_RS07940	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS07945	COG2814	Major facilitator Superfamily
C6N18_RS07950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6N18_RS07955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6N18_RS07965	COG2814	Major facilitator Superfamily
C6N18_RS07975	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS07990	COG0583	DNA-binding transcription factor activity
C6N18_RS08000	COG4770	biotin carboxylase activity
C6N18_RS08005	COG1024	Enoyl-CoA hydratase
C6N18_RS08010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6N18_RS08015	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS08020	COG1309	transcriptional regulator
C6N18_RS08025	COG0318	PFAM AMP-dependent synthetase and ligase
C6N18_RS08045	COG0583	DNA-binding transcription factor activity
C6N18_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS08130	COG0784	Response regulator, receiver
C6N18_RS08130	COG2205	protein histidine kinase activity
C6N18_RS08150	COG0765	amino acid transport
C6N18_RS08155	COG0765	amino acid transport
C6N18_RS08160	COG1126	abc transporter atp-binding protein
C6N18_RS08165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N18_RS08170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6N18_RS08180	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS08185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6N18_RS08190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6N18_RS08195	COG1045	serine acetyltransferase
C6N18_RS08210	COG0583	DNA-binding transcription factor activity
C6N18_RS08215	COG0625	glutathione transferase activity
C6N18_RS08220	COG0625	glutathione transferase activity
C6N18_RS08225	COG0583	DNA-binding transcription factor activity
C6N18_RS08235	COG1346	cytolysis
C6N18_RS08240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6N18_RS08255	COG2814	Major facilitator Superfamily
C6N18_RS08265	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C6N18_RS08270	COG3052	prosthetic group binding
C6N18_RS08290	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6N18_RS08310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6N18_RS08320	COG1294	oxidase, subunit
C6N18_RS08325	COG1271	oxidase subunit
C6N18_RS08350	COG0477	Major facilitator Superfamily
C6N18_RS08360	COG4521	taurine ABC transporter
C6N18_RS08365	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6N18_RS08370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6N18_RS08375	COG2175	clavaminate synthase activity
C6N18_RS08385	COG1953	Uracil, thiamine, allantoin
C6N18_RS08395	COG0583	DNA-binding transcription factor activity
C6N18_RS08405	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C6N18_RS08420	COG0640	Transcriptional regulator
C6N18_RS08425	COG0798	PFAM Bile acid sodium symporter
C6N18_RS08430	COG0583	DNA-binding transcription factor activity
C6N18_RS08445	COG3634	alkyl hydroperoxide reductase activity
C6N18_RS08480	COG1301	dicarboxylic acid transport
C6N18_RS08485	COG0436	Aminotransferase
C6N18_RS08495	COG0386	Belongs to the glutathione peroxidase family
C6N18_RS08535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C6N18_RS08560	COG0012	GTP binding
C6N18_RS08565	COG2011	ABC-type metal ion transport system permease component
C6N18_RS08570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6N18_RS08580	COG1464	Belongs to the NlpA lipoprotein family
C6N18_RS08610	COG0765	amino acid transport
C6N18_RS08615	COG0765	amino acid transport
C6N18_RS08620	COG1126	abc transporter atp-binding protein
C6N18_RS08630	COG1522	sequence-specific DNA binding
C6N18_RS08645	COG1309	transcriptional regulator
C6N18_RS08665	COG0583	DNA-binding transcription factor activity
C6N18_RS08675	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6N18_RS08685	COG0697	spore germination
C6N18_RS08715	COG3121	Chaperone
C6N18_RS08720	COG3539	Fimbrial protein
C6N18_RS08745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6N18_RS08745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6N18_RS08790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6N18_RS08800	COG2353	YceI-like domain
C6N18_RS08810	COG3698	Phosphodiester glycosidase
C6N18_RS08825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C6N18_RS08830	COG0506	proline dehydrogenase activity
C6N18_RS08830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6N18_RS08830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6N18_RS08840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6N18_RS08845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6N18_RS08865	COG1132	(ABC) transporter
C6N18_RS08870	COG3122	Protein conserved in bacteria
C6N18_RS08875	COG3619	membrane
C6N18_RS08885	COG0640	Transcriptional regulator
C6N18_RS08895	COG2850	peptidyl-arginine hydroxylation
C6N18_RS08900	COG0424	maF-like protein
C6N18_RS08920	COG0191	fructose-bisphosphate aldolase activity
C6N18_RS08925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6N18_RS08940	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6N18_RS08950	COG1192	Involved in chromosome partitioning
C6N18_RS08955	COG1475	DNA binding
C6N18_RS08960	COG0811	peptide transport
C6N18_RS08970	COG1132	(ABC) transporter
C6N18_RS08975	COG1663	tetraacyldisaccharide 4'-kinase activity
C6N18_RS08995	COG0084	hydrolase, TatD family'
C6N18_RS09060	COG0776	regulation of translation
C6N18_RS09090	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6N18_RS09095	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6N18_RS09120	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
C6N18_RS09140	COG0339	signal peptide processing
C6N18_RS09150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6N18_RS09185	COG0702	epimerase
C6N18_RS09190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6N18_RS09210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6N18_RS09240	COG0316	Belongs to the HesB IscA family
C6N18_RS09245	COG0822	iron-sulfur transferase activity
C6N18_RS09270	COG0776	regulation of translation
C6N18_RS09275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6N18_RS09280	COG2207	Transcriptional regulator
C6N18_RS09285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6N18_RS09290	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS09295	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS09310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6N18_RS09325	COG2814	Major facilitator Superfamily
C6N18_RS09330	COG4264	IucA IucC family
C6N18_RS09335	COG4264	IucA IucC family
C6N18_RS09345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6N18_RS09375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6N18_RS09390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C6N18_RS09395	COG0406	alpha-ribazole phosphatase activity
C6N18_RS09410	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6N18_RS09415	COG0730	response to heat
C6N18_RS09435	COG4773	Receptor
C6N18_RS09440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6N18_RS09495	COG2226	methyltransferase
C6N18_RS09520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6N18_RS09555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6N18_RS09565	COG0133	tryptophan synthase activity
C6N18_RS09580	COG3706	GGDEF domain
C6N18_RS09595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6N18_RS09600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6N18_RS09605	COG0022	dehydrogenase e1 component
C6N18_RS09610	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6N18_RS09615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6N18_RS09625	COG1063	alcohol dehydrogenase
C6N18_RS09630	COG3781	membrane
C6N18_RS09640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6N18_RS09640	COG3453	Protein conserved in bacteria
C6N18_RS09650	COG0730	response to heat
C6N18_RS09665	COG3708	Transcriptional regulator
C6N18_RS09665	COG2207	Transcriptional regulator
C6N18_RS09670	COG1733	regulation of RNA biosynthetic process
C6N18_RS09675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6N18_RS09685	COG2188	Transcriptional regulator
C6N18_RS09700	COG4521	taurine ABC transporter
C6N18_RS09705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6N18_RS09725	COG0477	Major facilitator Superfamily
C6N18_RS09735	COG1027	Aspartate ammonia-lyase
C6N18_RS09750	COG0583	DNA-binding transcription factor activity
C6N18_RS09755	COG0583	DNA-binding transcription factor activity
C6N18_RS09760	COG0183	Belongs to the thiolase family
C6N18_RS09765	COG2031	fatty acid transporter
C6N18_RS09780	COG0583	DNA-binding transcription factor activity
C6N18_RS09790	COG2610	gluconate transmembrane transporter activity
C6N18_RS09795	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS09800	COG2207	Transcriptional regulator
C6N18_RS09815	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS09825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS09840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6N18_RS09840	COG0543	2 iron, 2 sulfur cluster binding
C6N18_RS09845	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C6N18_RS09850	COG4638	Rieske (2fe-2S)
C6N18_RS09860	COG0725	ABC transporter, periplasmic molybdate-binding protein
C6N18_RS09865	COG4149	molybdate abc transporter
C6N18_RS09870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C6N18_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS09880	COG3433	isochorismatase activity
C6N18_RS09880	COG1535	isochorismatase
C6N18_RS09945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6N18_RS09960	COG0753	catalase activity
C6N18_RS09970	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C6N18_RS09995	COG3539	Fimbrial protein
C6N18_RS10090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6N18_RS10100	COG2072	flavoprotein involved in K transport
C6N18_RS10110	COG1538	Outer membrane efflux protein
C6N18_RS10115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6N18_RS10120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS10130	COG2205	protein histidine kinase activity
C6N18_RS10140	COG2207	Transcriptional regulator
C6N18_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS10165	COG1073	alpha beta
C6N18_RS10205	COG0556	nucleotide-excision repair
C6N18_RS10220	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6N18_RS10280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6N18_RS10295	COG2084	Dehydrogenase
C6N18_RS10305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6N18_RS10310	COG0583	DNA-binding transcription factor activity
C6N18_RS10320	COG0129	dihydroxy-acid dehydratase activity
C6N18_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS10340	COG1566	PFAM secretion protein HlyD family protein
C6N18_RS10355	COG0583	DNA-binding transcription factor activity
C6N18_RS10370	COG2188	Transcriptional regulator
C6N18_RS10445	COG1473	amidohydrolase
C6N18_RS10455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6N18_RS10455	COG0475	glutathione-regulated potassium exporter activity
C6N18_RS10465	COG0583	DNA-binding transcription factor activity
C6N18_RS10470	COG1335	isochorismatase
C6N18_RS10490	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS10500	COG4689	acetoacetate decarboxylase
C6N18_RS10515	COG1309	transcriptional regulator
C6N18_RS10555	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS10555	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N18_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS10590	COG2186	Transcriptional regulator
C6N18_RS10600	COG0583	DNA-binding transcription factor activity
C6N18_RS10605	COG4948	Mandelate Racemase Muconate Lactonizing
C6N18_RS10610	COG4829	muconolactone delta-isomerase
C6N18_RS10620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6N18_RS10625	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6N18_RS10635	COG0183	Belongs to the thiolase family
C6N18_RS10640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6N18_RS10650	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS10660	COG3733	amine oxidase
C6N18_RS10670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS10690	COG4638	Rieske (2fe-2S)
C6N18_RS10710	COG0154	amidase activity
C6N18_RS10720	COG2814	Major facilitator Superfamily
C6N18_RS10745	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS10750	COG0583	DNA-binding transcription factor activity
C6N18_RS10755	COG1414	Transcriptional regulator
C6N18_RS10770	COG2391	methyltransferase activity
C6N18_RS10780	COG4993	Dehydrogenase
C6N18_RS10785	COG3659	wide pore channel activity
C6N18_RS10790	COG3420	alginic acid biosynthetic process
C6N18_RS10795	COG0710	3-dehydroquinate dehydratase activity
C6N18_RS10800	COG3485	protocatechuate 3,4-dioxygenase
C6N18_RS10805	COG3485	protocatechuate 3,4-dioxygenase
C6N18_RS10810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6N18_RS10815	COG2271	Major facilitator Superfamily
C6N18_RS10820	COG0596	Alpha beta hydrolase
C6N18_RS10825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6N18_RS10830	COG0183	Belongs to the thiolase family
C6N18_RS10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6N18_RS10840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6N18_RS10850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C6N18_RS10855	COG2323	membrane
C6N18_RS10900	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS10900	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6N18_RS10925	COG0542	response to heat
C6N18_RS10930	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6N18_RS10960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6N18_RS10965	COG0569	domain protein
C6N18_RS10970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6N18_RS10985	COG4774	siderophore transport
C6N18_RS10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6N18_RS11000	COG1585	Membrane protein implicated in regulation of membrane protease activity
C6N18_RS11015	COG1294	oxidase, subunit
C6N18_RS11020	COG4890	Cyd operon protein YbgT
C6N18_RS11030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C6N18_RS11040	COG0552	protein localization to endoplasmic reticulum
C6N18_RS11065	COG0517	IMP dehydrogenase activity
C6N18_RS11065	COG0516	GMP reductase activity
C6N18_RS11070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6N18_RS11075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C6N18_RS11085	COG0583	DNA-binding transcription factor activity
C6N18_RS11090	COG0024	Methionine aminopeptidase
C6N18_RS11120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6N18_RS11120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6N18_RS11125	COG1105	Belongs to the carbohydrate kinase PfkB family
C6N18_RS11130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6N18_RS11130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6N18_RS11130	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C6N18_RS11150	COG5001	Diguanylate cyclase
C6N18_RS11150	COG3300	MHYT domain
C6N18_RS11165	COG2135	peptidase activity
C6N18_RS11170	COG0659	secondary active sulfate transmembrane transporter activity
C6N18_RS11185	COG1113	amino acid transport
C6N18_RS11195	COG1522	sequence-specific DNA binding
C6N18_RS11220	COG1011	Hydrolase
C6N18_RS11225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6N18_RS11235	COG2137	regulation of response to DNA damage stimulus
C6N18_RS11250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6N18_RS11285	COG0575	Belongs to the CDS family
C6N18_RS11290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6N18_RS11315	COG3852	Histidine kinase
C6N18_RS11320	COG2204	response regulator
C6N18_RS11380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6N18_RS11385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C6N18_RS11405	COG0697	spore germination
C6N18_RS11420	COG0303	'Molybdopterin
C6N18_RS11425	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6N18_RS11425	COG0315	cyclic pyranopterin monophosphate synthase activity
C6N18_RS11440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6N18_RS11445	COG0243	molybdopterin cofactor binding
C6N18_RS11455	COG0243	molybdopterin cofactor binding
C6N18_RS11460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6N18_RS11465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6N18_RS11465	COG2146	nitrite reductase [NAD(P)H] activity
C6N18_RS11475	COG0745	RESPONSE REGULATOR receiver
C6N18_RS11480	COG1116	anion transmembrane transporter activity
C6N18_RS11480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6N18_RS11500	COG0511	ligase activity, forming carbon-carbon bonds
C6N18_RS11515	COG2814	Major facilitator Superfamily
C6N18_RS11535	COG0069	glutamate synthase activity
C6N18_RS11555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6N18_RS11565	COG1454	alcohol dehydrogenase
C6N18_RS11570	COG0824	Thioesterase
C6N18_RS11580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6N18_RS11595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6N18_RS11600	COG2030	dehydratase
C6N18_RS11610	COG0183	Belongs to the thiolase family
C6N18_RS11620	COG0583	DNA-binding transcription factor activity
C6N18_RS11625	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6N18_RS11635	COG1522	sequence-specific DNA binding
C6N18_RS11640	COG3135	benzoate transporter
C6N18_RS11650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6N18_RS11665	COG0589	response to stress
C6N18_RS11670	COG0488	(ABC) transporter
C6N18_RS11690	COG4773	Receptor
C6N18_RS11720	COG0668	transmembrane transport
C6N18_RS11730	COG1309	transcriptional regulator
C6N18_RS11750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6N18_RS11770	COG1605	Chorismate mutase
C6N18_RS11810	COG0308	aminopeptidase N
C6N18_RS11835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6N18_RS11840	COG1454	alcohol dehydrogenase
C6N18_RS11860	COG0531	amino acid
C6N18_RS11865	COG4303	Ethanolamine ammonia lyase large subunit
C6N18_RS11870	COG4302	ethanolamine ammonia-lyase activity
C6N18_RS11875	COG0519	Catalyzes the synthesis of GMP from XMP
C6N18_RS11875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6N18_RS11880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6N18_RS11905	COG0697	spore germination
C6N18_RS11910	COG1923	regulation of RNA biosynthetic process
C6N18_RS11920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6N18_RS11925	COG0802	atpase or kinase
C6N18_RS11945	COG1187	pseudouridine synthase activity
C6N18_RS11960	COG0583	DNA-binding transcription factor activity
C6N18_RS11975	COG2814	Major facilitator Superfamily
C6N18_RS11980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6N18_RS12010	COG0729	surface antigen
C6N18_RS12030	COG0174	glutamine synthetase
C6N18_RS12035	COG0745	RESPONSE REGULATOR receiver
C6N18_RS12040	COG2205	protein histidine kinase activity
C6N18_RS12050	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C6N18_RS12055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C6N18_RS12080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6N18_RS12085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6N18_RS12090	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS12105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6N18_RS12110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6N18_RS12130	COG0583	DNA-binding transcription factor activity
C6N18_RS12150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6N18_RS12160	COG3658	cytochrome
C6N18_RS12165	COG1215	transferase activity, transferring glycosyl groups
C6N18_RS12170	COG0726	polysaccharide deacetylase
C6N18_RS12170	COG1649	PFAM Uncharacterised BCR, COG1649
C6N18_RS12195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6N18_RS12200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6N18_RS12210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C6N18_RS12235	COG0305	Participates in initiation and elongation during chromosome replication
C6N18_RS12240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6N18_RS12250	COG1305	Transglutaminase-like
C6N18_RS12260	COG2308	Evidence 4 Homologs of previously reported genes of
C6N18_RS12290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C6N18_RS12295	COG0138	bifunctional purine biosynthesis protein purh
C6N18_RS12300	COG0151	Belongs to the GarS family
C6N18_RS12305	COG1464	Belongs to the NlpA lipoprotein family
C6N18_RS12310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6N18_RS12315	COG2011	ABC-type metal ion transport system permease component
C6N18_RS12320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6N18_RS12330	COG1301	dicarboxylic acid transport
C6N18_RS12360	COG1794	racemase activity, acting on amino acids and derivatives
C6N18_RS12380	COG0745	RESPONSE REGULATOR receiver
C6N18_RS12385	COG0642	Histidine kinase
C6N18_RS12390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6N18_RS12400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6N18_RS12440	COG2351	hydroxyisourate hydrolase activity
C6N18_RS12450	COG3008	intermembrane lipid transfer
C6N18_RS12450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6N18_RS12455	COG2995	paraquat-inducible protein a
C6N18_RS12480	COG0477	Major facilitator Superfamily
C6N18_RS12540	COG2186	Transcriptional regulator
C6N18_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS12565	COG0583	DNA-binding transcription factor activity
C6N18_RS12575	COG0786	glutamate:sodium symporter activity
C6N18_RS12580	COG3243	poly(R)-hydroxyalkanoic acid synthase
C6N18_RS12605	COG3111	PFAM Bacterial OB fold (BOF) protein
C6N18_RS12705	COG1610	YqeY-like protein
C6N18_RS12710	COG4783	chaperone-mediated protein folding
C6N18_RS12735	COG1286	toxin biosynthetic process
C6N18_RS12945	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6N18_RS13035	COG0778	Nitroreductase
C6N18_RS13045	COG0513	Belongs to the DEAD box helicase family
C6N18_RS13065	COG2363	Small membrane protein
C6N18_RS13090	COG1234	tRNA 3'-trailer cleavage
C6N18_RS13095	COG2195	Cleaves the N-terminal amino acid of tripeptides
C6N18_RS13105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6N18_RS13115	COG2819	hydrolase of the alpha beta superfamily
C6N18_RS13120	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS13125	COG1301	dicarboxylic acid transport
C6N18_RS13135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6N18_RS13140	COG3139	Protein of unknown function (DUF1315)
C6N18_RS13145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6N18_RS13150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6N18_RS13160	COG0494	nUDIX hydrolase
C6N18_RS13170	COG0642	Histidine kinase
C6N18_RS13185	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C6N18_RS13195	COG1720	tRNA m6t6A37 methyltransferase activity
C6N18_RS13210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6N18_RS13215	COG0826	peptidase U32
C6N18_RS13220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6N18_RS13235	COG4160	amino acid transport
C6N18_RS13240	COG4215	(ABC) transporter
C6N18_RS13255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS13355	COG0739	heme binding
C6N18_RS13480	COG5410	chromosome segregation
C6N18_RS13685	COG0582	viral genome integration into host DNA
C6N18_RS13690	COG1131	(ABC) transporter
C6N18_RS13695	COG0842	Transport permease protein
C6N18_RS13710	COG0772	Belongs to the SEDS family
C6N18_RS13715	COG2951	lytic endotransglycosylase activity
C6N18_RS13740	COG2207	Transcriptional regulator
C6N18_RS13755	COG0052	Belongs to the universal ribosomal protein uS2 family
C6N18_RS13760	COG0024	Methionine aminopeptidase
C6N18_RS13770	COG2223	nitrite transmembrane transporter activity
C6N18_RS13780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6N18_RS13785	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6N18_RS13790	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS13805	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6N18_RS13810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6N18_RS13815	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6N18_RS13835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6N18_RS13840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6N18_RS13845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6N18_RS13880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6N18_RS13890	COG0174	glutamine synthetase
C6N18_RS13905	COG0512	Glutamine amidotransferase of anthranilate synthase
C6N18_RS13910	COG0308	aminopeptidase N
C6N18_RS13940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6N18_RS13950	COG0302	gtp cyclohydrolase
C6N18_RS13975	COG3739	integral membrane protein
C6N18_RS13990	COG1169	isochorismate synthase
C6N18_RS14000	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C6N18_RS14005	COG1132	(ABC) transporter
C6N18_RS14010	COG1132	(ABC) transporter
C6N18_RS14025	COG1535	isochorismatase
C6N18_RS14025	COG3433	isochorismatase activity
C6N18_RS14030	COG1021	2,3-dihydroxybenzoate-AMP ligase
C6N18_RS14035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6N18_RS14045	COG4774	siderophore transport
C6N18_RS14050	COG4607	ABC-type enterochelin transport system periplasmic component
C6N18_RS14055	COG4604	ABC transporter, ATP-binding protein
C6N18_RS14060	COG4605	iron ion homeostasis
C6N18_RS14065	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6N18_RS14070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6N18_RS14085	COG2964	Protein conserved in bacteria
C6N18_RS14095	COG1741	Belongs to the pirin family
C6N18_RS14150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6N18_RS14150	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C6N18_RS14155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6N18_RS14160	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS14170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6N18_RS14175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6N18_RS14180	COG0006	proline dipeptidase activity
C6N18_RS14185	COG0583	DNA-binding transcription factor activity
C6N18_RS14195	COG2879	small protein
C6N18_RS14200	COG1966	Carbon starvation protein
C6N18_RS14220	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C6N18_RS14245	COG1067	ATP-dependent peptidase activity
C6N18_RS14250	COG0583	DNA-binding transcription factor activity
C6N18_RS14275	COG1686	Belongs to the peptidase S11 family
C6N18_RS14280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6N18_RS14315	COG0616	signal peptide processing
C6N18_RS14320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6N18_RS14330	COG0573	inorganic phosphate transmembrane transporter activity
C6N18_RS14335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6N18_RS14340	COG1113	amino acid transport
C6N18_RS14345	COG3961	Belongs to the TPP enzyme family
C6N18_RS14350	COG1522	sequence-specific DNA binding
C6N18_RS14360	COG0076	glutamate decarboxylase activity
C6N18_RS14365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6N18_RS14375	COG1309	transcriptional regulator
C6N18_RS14390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6N18_RS14425	COG0352	thiamine-phosphate diphosphorylase activity
C6N18_RS14450	COG1203	CRISPR-associated helicase, Cas3
C6N18_RS14480	COG0612	Peptidase, M16
C6N18_RS14490	COG1823	symporter activity
C6N18_RS14495	COG0583	DNA-binding transcription factor activity
C6N18_RS14500	COG0477	Major facilitator Superfamily
C6N18_RS14525	COG1187	pseudouridine synthase activity
C6N18_RS14540	COG1686	Belongs to the peptidase S11 family
C6N18_RS14545	COG1252	NADH dehydrogenase
C6N18_RS14555	COG0415	Belongs to the DNA photolyase family
C6N18_RS14570	COG1215	transferase activity, transferring glycosyl groups
C6N18_RS14600	COG2070	2-Nitropropane dioxygenase
C6N18_RS14655	COG0556	nucleotide-excision repair
C6N18_RS14675	COG0436	Aminotransferase
C6N18_RS14705	COG4221	oxidoreductase activity
C6N18_RS14715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6N18_RS14720	COG1381	Involved in DNA repair and RecF pathway recombination
C6N18_RS14730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C6N18_RS14745	COG0681	Belongs to the peptidase S26 family
C6N18_RS14760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6N18_RS14780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6N18_RS14785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6N18_RS14790	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6N18_RS14800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C6N18_RS14805	COG4208	sulfate ABC transporter
C6N18_RS14810	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C6N18_RS14815	COG0583	DNA-binding transcription factor activity
C6N18_RS14820	COG4625	pathogenesis
C6N18_RS14835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C6N18_RS14850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6N18_RS14860	COG1056	cytidyltransferase-related domain
C6N18_RS14860	COG1051	belongs to the nudix hydrolase family
C6N18_RS14865	COG1024	Enoyl-CoA hydratase
C6N18_RS14875	COG2814	Major facilitator Superfamily
C6N18_RS14880	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6N18_RS14880	COG0047	phosphoribosylformylglycinamidine synthase activity
C6N18_RS14900	COG1473	amidohydrolase
C6N18_RS14905	COG0824	Thioesterase
C6N18_RS14925	COG0823	Involved in the tonB-independent uptake of proteins
C6N18_RS14945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6N18_RS14980	COG0628	permease
C6N18_RS14990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6N18_RS14995	COG0596	Alpha beta hydrolase
C6N18_RS15000	COG0616	signal peptide processing
C6N18_RS15000	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6N18_RS15025	COG1136	(ABC) transporter
C6N18_RS15030	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6N18_RS15060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS15080	COG0463	Glycosyl transferase, family 2
C6N18_RS15110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C6N18_RS15115	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS15120	COG2267	carboxylic ester hydrolase activity
C6N18_RS15130	COG0019	diaminopimelate decarboxylase activity
C6N18_RS15140	COG1113	amino acid transport
C6N18_RS15155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C6N18_RS15165	COG3339	Conserved Protein
C6N18_RS15170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6N18_RS15175	COG0243	molybdopterin cofactor binding
C6N18_RS15180	COG1929	Belongs to the glycerate kinase type-1 family
C6N18_RS15195	COG0778	Nitroreductase
C6N18_RS15230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6N18_RS15245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6N18_RS15270	COG0741	lytic transglycosylase activity
C6N18_RS15290	COG0584	glycerophosphoryl diester phosphodiesterase
C6N18_RS15350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6N18_RS15355	COG1597	lipid kinase activity
C6N18_RS15370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6N18_RS15375	COG0477	Major facilitator Superfamily
C6N18_RS15425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6N18_RS15430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6N18_RS15455	COG0505	Belongs to the CarA family
C6N18_RS15475	COG0589	response to stress
C6N18_RS15490	COG2843	Capsule synthesis protein
C6N18_RS15510	COG2321	neutral zinc metallopeptidase
C6N18_RS15515	COG2354	Protein conserved in bacteria
C6N18_RS15550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6N18_RS15575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6N18_RS15580	COG1053	succinate dehydrogenase
C6N18_RS15585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C6N18_RS15590	COG2009	succinate dehydrogenase
C6N18_RS15625	COG2921	Belongs to the UPF0250 family
C6N18_RS15630	COG0321	lipoyl(octanoyl) transferase activity
C6N18_RS15645	COG0531	amino acid
C6N18_RS15655	COG1733	regulation of RNA biosynthetic process
C6N18_RS15660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6N18_RS15665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6N18_RS15665	COG1648	precorrin-2 dehydrogenase activity
C6N18_RS15680	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C6N18_RS15710	COG0671	phosphoesterase, PA-phosphatase related
C6N18_RS15715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6N18_RS15725	COG1538	Outer membrane efflux protein
C6N18_RS15730	COG0393	Putative heavy-metal-binding
C6N18_RS15735	COG0393	Putative heavy-metal-binding
C6N18_RS15745	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS15755	COG0525	valine-tRNA ligase activity
C6N18_RS15775	COG0583	DNA-binding transcription factor activity
C6N18_RS15785	COG0004	ammonium transporteR
C6N18_RS15795	COG0642	Histidine kinase
C6N18_RS15800	COG0745	RESPONSE REGULATOR receiver
C6N18_RS15805	COG2194	sulfuric ester hydrolase activity
C6N18_RS15825	COG1752	Esterase of the alpha-beta hydrolase superfamily
C6N18_RS15840	COG2315	Protein conserved in bacteria
C6N18_RS15845	COG0142	geranyltranstransferase activity
C6N18_RS15850	COG2828	Protein conserved in bacteria
C6N18_RS15855	COG1113	amino acid transport
C6N18_RS15865	COG0582	viral genome integration into host DNA
C6N18_RS16275	COG2207	Transcriptional regulator
C6N18_RS16300	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6N18_RS16310	COG0560	Phosphoserine phosphatase
C6N18_RS16320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6N18_RS16330	COG1530	ribonuclease E activity
C6N18_RS16335	COG0424	maF-like protein
C6N18_RS16340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C6N18_RS16345	COG1792	Involved in formation and maintenance of cell shape
C6N18_RS16350	COG1077	Cell shape determining protein MreB Mrl
C6N18_RS16355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6N18_RS16365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6N18_RS16390	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C6N18_RS16395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6N18_RS16400	COG1752	Esterase of the alpha-beta hydrolase superfamily
C6N18_RS16405	COG1115	amino acid carrier protein
C6N18_RS16425	COG2814	Major facilitator Superfamily
C6N18_RS16430	COG1289	transmembrane transporter activity
C6N18_RS16440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6N18_RS16480	COG1376	ErfK ybiS ycfS ynhG family protein
C6N18_RS16485	COG2832	Protein of unknown function (DUF454)
C6N18_RS16495	COG5510	response to toxic substance
C6N18_RS16510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6N18_RS16525	COG0840	transmembrane signaling receptor activity
C6N18_RS16565	COG3422	double-strand break repair
C6N18_RS16570	COG2824	Alkylphosphonate utilization operon protein PhnA
C6N18_RS16575	COG3189	MarR family transcriptional regulator
C6N18_RS16585	COG0354	folic acid binding
C6N18_RS16590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6N18_RS16605	COG1902	pentaerythritol trinitrate reductase activity
C6N18_RS16610	COG4772	TonB-dependent receptor
C6N18_RS16615	COG2094	Belongs to the DNA glycosylase MPG family
C6N18_RS16640	COG1217	gtp-binding protein TYPA
C6N18_RS16645	COG2233	PERMEase
C6N18_RS16655	COG0833	amino acid
C6N18_RS16660	COG1690	Belongs to the RtcB family
C6N18_RS16665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6N18_RS16665	COG2885	chlorophyll binding
C6N18_RS16675	COG0183	Belongs to the thiolase family
C6N18_RS16695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6N18_RS16715	COG2207	Transcriptional regulator
C6N18_RS16720	COG0183	Belongs to the thiolase family
C6N18_RS16740	COG2153	protein acetylation
C6N18_RS16750	COG1272	protein, Hemolysin III
C6N18_RS16755	COG0477	Major facilitator Superfamily
C6N18_RS16770	COG0450	alkyl hydroperoxide reductase
C6N18_RS16790	COG0285	dihydrofolate synthase activity
C6N18_RS16840	COG2096	Adenosyltransferase
C6N18_RS16860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C6N18_RS16865	COG0745	RESPONSE REGULATOR receiver
C6N18_RS16870	COG2205	protein histidine kinase activity
C6N18_RS16880	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS16885	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS16950	COG0438	transferase activity, transferring glycosyl groups
C6N18_RS16955	COG0463	Glycosyl transferase, family 2
C6N18_RS16960	COG0726	polysaccharide deacetylase
C6N18_RS16980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6N18_RS16985	COG2205	protein histidine kinase activity
C6N18_RS16990	COG4695	Portal protein
C6N18_RS17130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6N18_RS17140	COG3646	Phage regulatory protein
C6N18_RS17180	COG0629	single-stranded DNA binding
C6N18_RS17185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6N18_RS17230	COG1862	Preprotein translocase
C6N18_RS17245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6N18_RS17255	COG3781	membrane
C6N18_RS17260	COG0613	PHP domain protein
C6N18_RS17270	COG2350	Protein conserved in bacteria
C6N18_RS17300	COG1607	acyl-coa hydrolase
C6N18_RS17360	COG2199	diguanylate cyclase activity
C6N18_RS17370	COG1408	metallophosphoesterase
C6N18_RS17375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6N18_RS17385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6N18_RS17405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6N18_RS17410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6N18_RS17425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6N18_RS17435	COG2969	positive regulation of protein catabolic process
C6N18_RS17455	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS17460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6N18_RS17475	COG1309	transcriptional regulator
C6N18_RS17480	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS17525	COG1183	phosphatidylcholine synthase activity
C6N18_RS17530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C6N18_RS17560	COG1196	nuclear chromosome segregation
C6N18_RS17560	COG0739	heme binding
C6N18_RS17560	COG0741	lytic transglycosylase activity
C6N18_RS17570	COG1702	phosphate starvation-inducible protein PhoH
C6N18_RS17605	COG1295	ribonuclease BN
C6N18_RS17610	COG0697	spore germination
C6N18_RS17615	COG2169	Transcriptional regulator
C6N18_RS17620	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6N18_RS17665	COG0557	exoribonuclease II activity
C6N18_RS17670	COG0339	signal peptide processing
C6N18_RS17675	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C6N18_RS17705	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C6N18_RS17710	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS17865	COG0626	cystathionine gamma-synthase activity
C6N18_RS17870	COG0433	COG0433 Predicted ATPase
C6N18_RS17875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6N18_RS17875	COG1017	nitric oxide dioxygenase activity
C6N18_RS17880	COG1959	2 iron, 2 sulfur cluster binding
C6N18_RS17895	COG1301	dicarboxylic acid transport
C6N18_RS17900	COG1946	Acyl-CoA thioesterase
C6N18_RS17920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6N18_RS17925	COG1040	competence protein
C6N18_RS17930	COG0494	nUDIX hydrolase
C6N18_RS17940	COG0598	Magnesium transport protein CorA
C6N18_RS17950	COG2854	intermembrane phospholipid transfer
C6N18_RS17960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6N18_RS17965	COG1127	ABC transporter
C6N18_RS17975	COG0513	Belongs to the DEAD box helicase family
C6N18_RS17995	COG0408	coproporphyrinogen oxidase activity
C6N18_RS18010	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS18020	COG1983	PspC domain protein
C6N18_RS18025	COG0517	IMP dehydrogenase activity
C6N18_RS18075	COG0583	DNA-binding transcription factor activity
C6N18_RS18115	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS18125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6N18_RS18130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6N18_RS18135	COG0833	amino acid
C6N18_RS18165	COG1192	Involved in chromosome partitioning
C6N18_RS18170	COG0628	permease
C6N18_RS18180	COG1289	transmembrane transporter activity
C6N18_RS18195	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6N18_RS18200	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C6N18_RS18210	COG0277	FAD linked oxidase domain protein
C6N18_RS18215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6N18_RS18240	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6N18_RS18245	COG5380	lipid catabolic process
C6N18_RS18265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6N18_RS18315	COG0194	GDP metabolic process
C6N18_RS18330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6N18_RS18350	COG3307	-O-antigen
C6N18_RS18365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C6N18_RS18370	COG1704	LemA family
C6N18_RS18380	COG0493	'glutamate synthase
C6N18_RS18385	COG0067	glutamate synthase
C6N18_RS18385	COG0069	glutamate synthase activity
C6N18_RS18385	COG0070	glutamate synthase
C6N18_RS18435	COG2226	methyltransferase
C6N18_RS18450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6N18_RS18455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6N18_RS18500	COG0833	amino acid
C6N18_RS18565	COG0488	(ABC) transporter
C6N18_RS18570	COG2873	o-acetylhomoserine
C6N18_RS18575	COG4221	oxidoreductase activity
C6N18_RS18580	COG0659	secondary active sulfate transmembrane transporter activity
C6N18_RS18605	COG0427	acetyl-CoA hydrolase
C6N18_RS18635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6N18_RS18675	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6N18_RS18735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6N18_RS18745	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6N18_RS18755	COG1733	regulation of RNA biosynthetic process
C6N18_RS18770	COG1733	regulation of RNA biosynthetic process
C6N18_RS18795	COG0667	Aldo Keto reductase
C6N18_RS18815	COG0583	DNA-binding transcription factor activity
C6N18_RS18820	COG2814	Major facilitator Superfamily
C6N18_RS18850	COG1335	isochorismatase
C6N18_RS18860	COG1012	belongs to the aldehyde dehydrogenase family
C6N18_RS18865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6N18_RS18875	COG1113	amino acid transport
C6N18_RS18885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C6N18_RS18900	COG2814	Major facilitator Superfamily
C6N18_RS18910	COG0352	thiamine-phosphate diphosphorylase activity
C6N18_RS18910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C6N18_RS18910	COG0351	phosphomethylpyrimidine kinase
C6N18_RS18930	COG1309	transcriptional regulator
C6N18_RS18935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6N18_RS18960	COG3173	Aminoglycoside phosphotransferase
C6N18_RS18965	COG0488	(ABC) transporter
C6N18_RS18980	COG0482	sulfurtransferase activity
C6N18_RS19085	COG0697	spore germination
C6N18_RS19105	COG0789	Transcriptional regulator
C6N18_RS19205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6N18_RS19235	COG0789	Transcriptional regulator
C6N18_RS19250	COG0640	Transcriptional regulator
C6N18_RS19260	COG0798	PFAM Bile acid sodium symporter
C6N18_RS19265	COG0431	NADPH-dependent FMN reductase
C6N18_RS19270	COG0492	ferredoxin-NADP+ reductase activity
C6N18_RS19275	COG2072	flavoprotein involved in K transport
C6N18_RS19305	COG0606	chelatase, subunit chli
C6N18_RS19310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6N18_RS19320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6N18_RS19335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6N18_RS19350	COG0318	PFAM AMP-dependent synthetase and ligase
C6N18_RS19360	COG0477	Major facilitator Superfamily
C6N18_RS19365	COG2860	membrane
C6N18_RS19370	COG3012	SEC-C Motif Domain Protein
C6N18_RS19375	COG1253	flavin adenine dinucleotide binding
C6N18_RS19385	COG0477	Major facilitator Superfamily
C6N18_RS19395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6N18_RS19430	COG0655	NAD(P)H dehydrogenase (quinone) activity
C6N18_RS19440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6N18_RS19475	COG1309	transcriptional regulator
C6N18_RS19510	COG0758	DNA mediated transformation
C6N18_RS19520	COG0697	spore germination
C6N18_RS19525	COG1309	transcriptional regulator
C6N18_RS19540	COG0386	Belongs to the glutathione peroxidase family
C6N18_RS19605	COG1121	(ABC) transporter
C6N18_RS19610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6N18_RS19615	COG1280	lysine exporter protein (LysE YggA)
C6N18_RS19620	COG2837	iron assimilation
C6N18_RS19625	COG0281	malic enzyme
C6N18_RS19670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6N18_RS19670	COG0519	Catalyzes the synthesis of GMP from XMP
C6N18_RS19675	COG4399	Belongs to the UPF0754 family
C6N18_RS19680	COG2259	Doxx family
C6N18_RS19685	COG0586	Pfam SNARE associated Golgi protein
C6N18_RS19700	COG1192	Involved in chromosome partitioning
C6N18_RS19710	COG0271	Belongs to the BolA IbaG family
C6N18_RS19730	COG2267	carboxylic ester hydrolase activity
C6N18_RS19750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6N18_RS19750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6N18_RS19750	COG3321	synthase
C6N18_RS19750	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C6N18_RS19755	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS19765	COG2197	response regulator
C6N18_RS19775	COG3916	Acyl-homoserine-lactone synthase
C6N18_RS19780	COG0477	Major facilitator Superfamily
C6N18_RS19785	COG1024	Enoyl-CoA hydratase
C6N18_RS19790	COG1024	Enoyl-CoA hydratase
C6N18_RS19795	COG1960	acyl-CoA dehydrogenase activity
C6N18_RS19800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6N18_RS19820	COG1113	amino acid transport
C6N18_RS19825	COG1113	amino acid transport
C6N18_RS19830	COG0251	oxidation-reduction process
C6N18_RS19870	COG0564	pseudouridine synthase activity
C6N18_RS19920	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6N18_RS19935	COG1802	Transcriptional regulator
C6N18_RS19940	COG1448	Aminotransferase
C6N18_RS19945	COG0277	FAD linked oxidase domain protein
C6N18_RS19955	COG2186	Transcriptional regulator
C6N18_RS19965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6N18_RS19980	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6N18_RS19990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6N18_RS20000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6N18_RS20005	COG0438	transferase activity, transferring glycosyl groups
C6N18_RS20020	COG0438	transferase activity, transferring glycosyl groups
C6N18_RS20035	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C6N18_RS20065	COG0728	peptidoglycan biosynthetic process
C6N18_RS20070	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6N18_RS20125	COG0546	phosphoglycolate phosphatase activity
C6N18_RS20130	COG1028	Short-chain dehydrogenase reductase Sdr
C6N18_RS20150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6N18_RS20155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6N18_RS20160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6N18_RS20165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6N18_RS20170	COG1116	anion transmembrane transporter activity
C6N18_RS20175	COG1309	transcriptional regulator
C6N18_RS20180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6N18_RS20195	COG0196	riboflavin kinase activity
C6N18_RS20200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6N18_RS20210	COG1047	Peptidyl-prolyl cis-trans
C6N18_RS20250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6N18_RS20255	COG0657	acetylesterase activity
C6N18_RS20305	COG2951	lytic endotransglycosylase activity
C6N18_RS20310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6N18_RS20330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6N18_RS20340	COG0671	phosphoesterase, PA-phosphatase related
C6N18_RS20345	COG0861	Integral membrane protein TerC family
C6N18_RS20355	COG0754	glutathionylspermidine amidase activity
C6N18_RS20365	COG0402	S-adenosylhomocysteine deaminase activity
C6N18_RS20380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6N18_RS20385	COG1230	cation diffusion facilitator family transporter
C6N18_RS20400	COG0706	membrane insertase activity