locus-tag	class	description
C5B74_RS00085	COG2433	Pfam Transposase IS66
C5B74_RS00100	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5B74_RS00125	COG1192	Involved in chromosome partitioning
C5B74_RS00195	COG0583	DNA-binding transcription factor activity
C5B74_RS00210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B74_RS00235	COG0589	response to stress
C5B74_RS00240	COG0659	secondary active sulfate transmembrane transporter activity
C5B74_RS00245	COG3077	Addiction module antitoxin, RelB DinJ family
C5B74_RS00280	COG3657	addiction module killer protein
C5B74_RS00285	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5B74_RS00330	COG0592	DNA-directed DNA polymerase activity
C5B74_RS00340	COG0187	DNA topoisomerase II activity
C5B74_RS00350	COG0586	Pfam SNARE associated Golgi protein
C5B74_RS00355	COG0488	(ABC) transporter
C5B74_RS00380	COG0596	Alpha beta hydrolase
C5B74_RS00385	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C5B74_RS00390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5B74_RS00435	COG0733	neurotransmitter:sodium symporter activity
C5B74_RS00475	COG2233	PERMEase
C5B74_RS00490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS00525	COG2814	Major facilitator Superfamily
C5B74_RS00530	COG0656	L-ascorbic acid biosynthetic process
C5B74_RS00535	COG0583	DNA-binding transcription factor activity
C5B74_RS00550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B74_RS00555	COG1064	alcohol dehydrogenase
C5B74_RS00560	COG2818	Glycosylase
C5B74_RS00575	COG1194	a g-specific adenine glycosylase
C5B74_RS00595	COG2983	Belongs to the UPF0260 family
C5B74_RS00600	COG2133	pyrroloquinoline quinone binding
C5B74_RS00605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5B74_RS00610	COG2116	formate transmembrane transporter activity
C5B74_RS00630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B74_RS00635	COG1335	isochorismatase
C5B74_RS00640	COG0385	Bile acid
C5B74_RS00645	COG0534	Mate efflux family protein
C5B74_RS00650	COG1683	Conserved Protein
C5B74_RS00670	COG0625	glutathione transferase activity
C5B74_RS00680	COG1113	amino acid transport
C5B74_RS00690	COG0523	cobalamin synthesis protein
C5B74_RS00700	COG2188	Transcriptional regulator
C5B74_RS00730	COG0010	Belongs to the arginase family
C5B74_RS00750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5B74_RS00755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5B74_RS00765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5B74_RS00770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5B74_RS00875	COG0534	Mate efflux family protein
C5B74_RS00880	COG0436	Aminotransferase
C5B74_RS00885	COG2733	membrane
C5B74_RS00900	COG2918	glutathione biosynthetic process
C5B74_RS00915	COG1388	LysM domain
C5B74_RS00915	COG0791	NLP P60 protein
C5B74_RS00935	COG3150	esterase
C5B74_RS00945	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS00950	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C5B74_RS00960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B74_RS00970	COG2233	PERMEase
C5B74_RS00975	COG2351	hydroxyisourate hydrolase activity
C5B74_RS01010	COG3706	GGDEF domain
C5B74_RS01025	COG1393	Belongs to the ArsC family
C5B74_RS01030	COG0708	Exodeoxyribonuclease III
C5B74_RS01050	COG0189	ligase activity
C5B74_RS01070	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5B74_RS01080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5B74_RS01095	COG4942	peptidase
C5B74_RS01105	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5B74_RS01115	COG2119	membrane
C5B74_RS01120	COG4774	siderophore transport
C5B74_RS01125	COG0426	domain, Protein
C5B74_RS01125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B74_RS01150	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5B74_RS01170	COG1902	pentaerythritol trinitrate reductase activity
C5B74_RS01175	COG1519	Transferase
C5B74_RS01180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5B74_RS01185	COG0668	transmembrane transport
C5B74_RS01195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B74_RS01200	COG1335	isochorismatase
C5B74_RS01205	COG1522	sequence-specific DNA binding
C5B74_RS01210	COG3328	transposase activity
C5B74_RS01235	COG2198	Histidine kinase
C5B74_RS01235	COG0784	Response regulator, receiver
C5B74_RS01235	COG2205	protein histidine kinase activity
C5B74_RS01240	COG3162	membrane
C5B74_RS01245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5B74_RS01255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B74_RS01275	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5B74_RS01280	COG1309	transcriptional regulator
C5B74_RS01300	COG0352	thiamine-phosphate diphosphorylase activity
C5B74_RS01300	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5B74_RS01300	COG0351	phosphomethylpyrimidine kinase
C5B74_RS01310	COG2814	Major facilitator Superfamily
C5B74_RS01325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5B74_RS01335	COG1113	amino acid transport
C5B74_RS01345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5B74_RS01350	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS01360	COG1335	isochorismatase
C5B74_RS01390	COG2814	Major facilitator Superfamily
C5B74_RS01395	COG0583	DNA-binding transcription factor activity
C5B74_RS01415	COG0667	Aldo Keto reductase
C5B74_RS01450	COG1733	regulation of RNA biosynthetic process
C5B74_RS01460	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5B74_RS01525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5B74_RS01540	COG2329	Antibiotic biosynthesis monooxygenase
C5B74_RS01570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5B74_RS01600	COG0427	acetyl-CoA hydrolase
C5B74_RS01625	COG0659	secondary active sulfate transmembrane transporter activity
C5B74_RS01630	COG4221	oxidoreductase activity
C5B74_RS01635	COG2873	o-acetylhomoserine
C5B74_RS01640	COG0488	(ABC) transporter
C5B74_RS01725	COG0833	amino acid
C5B74_RS01770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5B74_RS01775	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5B74_RS01790	COG2226	methyltransferase
C5B74_RS01840	COG0069	glutamate synthase activity
C5B74_RS01840	COG0070	glutamate synthase
C5B74_RS01840	COG0067	glutamate synthase
C5B74_RS01845	COG0493	'glutamate synthase
C5B74_RS01855	COG1704	LemA family
C5B74_RS01860	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C5B74_RS01870	COG4969	Belongs to the N-Me-Phe pilin family
C5B74_RS01875	COG3307	-O-antigen
C5B74_RS01895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5B74_RS01910	COG0194	GDP metabolic process
C5B74_RS01960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5B74_RS01980	COG5380	lipid catabolic process
C5B74_RS01985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5B74_RS02010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5B74_RS02015	COG0277	FAD linked oxidase domain protein
C5B74_RS02025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5B74_RS02030	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5B74_RS02045	COG1289	transmembrane transporter activity
C5B74_RS02055	COG0628	permease
C5B74_RS02060	COG1192	Involved in chromosome partitioning
C5B74_RS02090	COG0833	amino acid
C5B74_RS02095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5B74_RS02100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5B74_RS02110	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS02150	COG0583	DNA-binding transcription factor activity
C5B74_RS02195	COG0517	IMP dehydrogenase activity
C5B74_RS02200	COG1983	PspC domain protein
C5B74_RS02210	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS02225	COG0408	coproporphyrinogen oxidase activity
C5B74_RS02245	COG0513	Belongs to the DEAD box helicase family
C5B74_RS02255	COG1127	ABC transporter
C5B74_RS02260	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C5B74_RS02270	COG2854	intermembrane phospholipid transfer
C5B74_RS02280	COG0598	Magnesium transport protein CorA
C5B74_RS02290	COG0494	nUDIX hydrolase
C5B74_RS02295	COG1040	competence protein
C5B74_RS02300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5B74_RS02320	COG1946	Acyl-CoA thioesterase
C5B74_RS02325	COG1301	dicarboxylic acid transport
C5B74_RS02340	COG1959	2 iron, 2 sulfur cluster binding
C5B74_RS02345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5B74_RS02345	COG1017	nitric oxide dioxygenase activity
C5B74_RS02350	COG0433	COG0433 Predicted ATPase
C5B74_RS02355	COG0626	cystathionine gamma-synthase activity
C5B74_RS02510	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS02515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C5B74_RS02545	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C5B74_RS02550	COG0339	signal peptide processing
C5B74_RS02555	COG0557	exoribonuclease II activity
C5B74_RS02600	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5B74_RS02605	COG2169	Transcriptional regulator
C5B74_RS02610	COG0697	spore germination
C5B74_RS02615	COG1295	ribonuclease BN
C5B74_RS02650	COG1702	phosphate starvation-inducible protein PhoH
C5B74_RS02660	COG0739	heme binding
C5B74_RS02660	COG0741	lytic transglycosylase activity
C5B74_RS02660	COG1196	nuclear chromosome segregation
C5B74_RS02690	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C5B74_RS02695	COG1183	phosphatidylcholine synthase activity
C5B74_RS02740	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS02745	COG1309	transcriptional regulator
C5B74_RS02760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B74_RS02765	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS02785	COG2969	positive regulation of protein catabolic process
C5B74_RS02795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5B74_RS02810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5B74_RS02815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C5B74_RS02835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5B74_RS02845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5B74_RS02850	COG1408	metallophosphoesterase
C5B74_RS02860	COG2199	diguanylate cyclase activity
C5B74_RS02920	COG1607	acyl-coa hydrolase
C5B74_RS02950	COG2350	Protein conserved in bacteria
C5B74_RS02960	COG0613	PHP domain protein
C5B74_RS02965	COG3781	membrane
C5B74_RS02975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5B74_RS02980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5B74_RS02990	COG1862	Preprotein translocase
C5B74_RS03040	COG2205	protein histidine kinase activity
C5B74_RS03045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C5B74_RS03065	COG0726	polysaccharide deacetylase
C5B74_RS03070	COG0463	Glycosyl transferase, family 2
C5B74_RS03075	COG0438	transferase activity, transferring glycosyl groups
C5B74_RS03140	COG0625	glutathione transferase activity
C5B74_RS03145	COG0583	DNA-binding transcription factor activity
C5B74_RS03150	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS03155	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS03165	COG2205	protein histidine kinase activity
C5B74_RS03170	COG0745	RESPONSE REGULATOR receiver
C5B74_RS03175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C5B74_RS03195	COG2096	Adenosyltransferase
C5B74_RS03245	COG0285	dihydrofolate synthase activity
C5B74_RS03265	COG0450	alkyl hydroperoxide reductase
C5B74_RS03280	COG0477	Major facilitator Superfamily
C5B74_RS03285	COG1272	protein, Hemolysin III
C5B74_RS03315	COG0183	Belongs to the thiolase family
C5B74_RS03320	COG2207	Transcriptional regulator
C5B74_RS03340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B74_RS03360	COG0183	Belongs to the thiolase family
C5B74_RS03370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C5B74_RS03370	COG2885	chlorophyll binding
C5B74_RS03375	COG1690	Belongs to the RtcB family
C5B74_RS03380	COG0833	amino acid
C5B74_RS03390	COG2233	PERMEase
C5B74_RS03395	COG1217	gtp-binding protein TYPA
C5B74_RS03420	COG2094	Belongs to the DNA glycosylase MPG family
C5B74_RS03425	COG4772	TonB-dependent receptor
C5B74_RS03430	COG1902	pentaerythritol trinitrate reductase activity
C5B74_RS03435	COG0679	Auxin Efflux Carrier
C5B74_RS03445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5B74_RS03450	COG0354	folic acid binding
C5B74_RS03460	COG3189	MarR family transcriptional regulator
C5B74_RS03465	COG2824	Alkylphosphonate utilization operon protein PhnA
C5B74_RS03470	COG3422	double-strand break repair
C5B74_RS03510	COG0840	transmembrane signaling receptor activity
C5B74_RS03530	COG5510	response to toxic substance
C5B74_RS03540	COG2832	Protein of unknown function (DUF454)
C5B74_RS03545	COG1376	ErfK ybiS ycfS ynhG family protein
C5B74_RS03585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5B74_RS03595	COG1289	transmembrane transporter activity
C5B74_RS03600	COG2814	Major facilitator Superfamily
C5B74_RS03620	COG1115	amino acid carrier protein
C5B74_RS03625	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5B74_RS03630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5B74_RS03635	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C5B74_RS03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5B74_RS03675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5B74_RS03680	COG1077	Cell shape determining protein MreB Mrl
C5B74_RS03685	COG1792	Involved in formation and maintenance of cell shape
C5B74_RS03690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C5B74_RS03695	COG0424	maF-like protein
C5B74_RS03700	COG1530	ribonuclease E activity
C5B74_RS03710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B74_RS03720	COG0560	Phosphoserine phosphatase
C5B74_RS03730	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5B74_RS03755	COG2207	Transcriptional regulator
C5B74_RS03775	COG1113	amino acid transport
C5B74_RS03780	COG2828	Protein conserved in bacteria
C5B74_RS03785	COG0142	geranyltranstransferase activity
C5B74_RS03790	COG2315	Protein conserved in bacteria
C5B74_RS03805	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5B74_RS03830	COG2194	sulfuric ester hydrolase activity
C5B74_RS03835	COG0745	RESPONSE REGULATOR receiver
C5B74_RS03840	COG0642	Histidine kinase
C5B74_RS03850	COG0004	ammonium transporteR
C5B74_RS03860	COG0583	DNA-binding transcription factor activity
C5B74_RS03880	COG0525	valine-tRNA ligase activity
C5B74_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS03900	COG0393	Putative heavy-metal-binding
C5B74_RS03905	COG0393	Putative heavy-metal-binding
C5B74_RS03910	COG1538	Outer membrane efflux protein
C5B74_RS03920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS03925	COG0671	phosphoesterase, PA-phosphatase related
C5B74_RS03955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5B74_RS03970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5B74_RS03970	COG1648	precorrin-2 dehydrogenase activity
C5B74_RS03975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5B74_RS03980	COG1733	regulation of RNA biosynthetic process
C5B74_RS03990	COG0531	amino acid
C5B74_RS04005	COG0321	lipoyl(octanoyl) transferase activity
C5B74_RS04010	COG2921	Belongs to the UPF0250 family
C5B74_RS04050	COG2009	succinate dehydrogenase
C5B74_RS04055	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C5B74_RS04060	COG1053	succinate dehydrogenase
C5B74_RS04065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5B74_RS04090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5B74_RS04110	COG2354	Protein conserved in bacteria
C5B74_RS04115	COG2321	neutral zinc metallopeptidase
C5B74_RS04155	COG2843	Capsule synthesis protein
C5B74_RS04170	COG0589	response to stress
C5B74_RS04190	COG0505	Belongs to the CarA family
C5B74_RS04215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5B74_RS04220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5B74_RS04270	COG0477	Major facilitator Superfamily
C5B74_RS04275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5B74_RS04290	COG1597	lipid kinase activity
C5B74_RS04295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5B74_RS04325	COG2433	Pfam Transposase IS66
C5B74_RS04335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B74_RS04340	COG0584	glycerophosphoryl diester phosphodiesterase
C5B74_RS04360	COG0741	lytic transglycosylase activity
C5B74_RS04385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5B74_RS04400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B74_RS04430	COG0778	Nitroreductase
C5B74_RS04445	COG1929	Belongs to the glycerate kinase type-1 family
C5B74_RS04450	COG0243	molybdopterin cofactor binding
C5B74_RS04455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5B74_RS04460	COG3339	Conserved Protein
C5B74_RS04470	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C5B74_RS04485	COG1113	amino acid transport
C5B74_RS04495	COG0019	diaminopimelate decarboxylase activity
C5B74_RS04505	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS04510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5B74_RS04540	COG0463	Glycosyl transferase, family 2
C5B74_RS04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS04590	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5B74_RS04595	COG1136	(ABC) transporter
C5B74_RS04600	COG2333	competence protein COMEC
C5B74_RS04600	COG0658	competence protein
C5B74_RS04610	COG0616	signal peptide processing
C5B74_RS04610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C5B74_RS04615	COG0596	Alpha beta hydrolase
C5B74_RS04620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5B74_RS04630	COG0628	permease
C5B74_RS04665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5B74_RS04685	COG0823	Involved in the tonB-independent uptake of proteins
C5B74_RS04705	COG0824	Thioesterase
C5B74_RS04710	COG1473	amidohydrolase
C5B74_RS04730	COG0047	phosphoribosylformylglycinamidine synthase activity
C5B74_RS04730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5B74_RS04735	COG2814	Major facilitator Superfamily
C5B74_RS04745	COG1024	Enoyl-CoA hydratase
C5B74_RS04750	COG1051	belongs to the nudix hydrolase family
C5B74_RS04750	COG1056	cytidyltransferase-related domain
C5B74_RS04760	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5B74_RS04775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5B74_RS04790	COG4625	pathogenesis
C5B74_RS04795	COG0583	DNA-binding transcription factor activity
C5B74_RS04800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C5B74_RS04805	COG4208	sulfate ABC transporter
C5B74_RS04810	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C5B74_RS04820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C5B74_RS04825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5B74_RS04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5B74_RS04850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B74_RS04865	COG0681	Belongs to the peptidase S26 family
C5B74_RS04880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5B74_RS04890	COG1381	Involved in DNA repair and RecF pathway recombination
C5B74_RS04895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C5B74_RS04905	COG4221	oxidoreductase activity
C5B74_RS04935	COG0436	Aminotransferase
C5B74_RS04955	COG0556	nucleotide-excision repair
C5B74_RS05150	COG5410	chromosome segregation
C5B74_RS05340	COG2070	2-Nitropropane dioxygenase
C5B74_RS05370	COG1215	transferase activity, transferring glycosyl groups
C5B74_RS05385	COG0415	Belongs to the DNA photolyase family
C5B74_RS05395	COG1252	NADH dehydrogenase
C5B74_RS05400	COG1686	Belongs to the peptidase S11 family
C5B74_RS05415	COG1187	pseudouridine synthase activity
C5B74_RS05440	COG0477	Major facilitator Superfamily
C5B74_RS05445	COG0583	DNA-binding transcription factor activity
C5B74_RS05450	COG1823	symporter activity
C5B74_RS05460	COG0612	Peptidase, M16
C5B74_RS05485	COG0352	thiamine-phosphate diphosphorylase activity
C5B74_RS05520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5B74_RS05535	COG1309	transcriptional regulator
C5B74_RS05545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5B74_RS05550	COG0076	glutamate decarboxylase activity
C5B74_RS05560	COG1522	sequence-specific DNA binding
C5B74_RS05565	COG3961	Belongs to the TPP enzyme family
C5B74_RS05570	COG1113	amino acid transport
C5B74_RS05575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5B74_RS05580	COG0573	inorganic phosphate transmembrane transporter activity
C5B74_RS05590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5B74_RS05595	COG0616	signal peptide processing
C5B74_RS05630	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5B74_RS05635	COG1686	Belongs to the peptidase S11 family
C5B74_RS05660	COG0583	DNA-binding transcription factor activity
C5B74_RS05665	COG1067	ATP-dependent peptidase activity
C5B74_RS05710	COG1966	Carbon starvation protein
C5B74_RS05715	COG2879	small protein
C5B74_RS05750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C5B74_RS05750	COG2508	Transcriptional regulator
C5B74_RS05770	COG1113	amino acid transport
C5B74_RS05775	COG0583	DNA-binding transcription factor activity
C5B74_RS05780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B74_RS05785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B74_RS05795	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS05800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B74_RS05805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C5B74_RS05805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B74_RS05840	COG2814	Major facilitator Superfamily
C5B74_RS05845	COG4948	Mandelate Racemase Muconate Lactonizing
C5B74_RS05855	COG1309	transcriptional regulator
C5B74_RS05875	COG1741	Belongs to the pirin family
C5B74_RS05885	COG2964	Protein conserved in bacteria
C5B74_RS05900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B74_RS05905	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B74_RS05910	COG4605	iron ion homeostasis
C5B74_RS05915	COG4604	ABC transporter, ATP-binding protein
C5B74_RS05920	COG4607	ABC-type enterochelin transport system periplasmic component
C5B74_RS05925	COG4774	siderophore transport
C5B74_RS05935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5B74_RS05940	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5B74_RS05945	COG3433	isochorismatase activity
C5B74_RS05945	COG1535	isochorismatase
C5B74_RS05960	COG1132	(ABC) transporter
C5B74_RS05965	COG1132	(ABC) transporter
C5B74_RS05970	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C5B74_RS05980	COG1169	isochorismate synthase
C5B74_RS05995	COG3739	integral membrane protein
C5B74_RS06015	COG0302	gtp cyclohydrolase
C5B74_RS06025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C5B74_RS06055	COG0308	aminopeptidase N
C5B74_RS06060	COG0512	Glutamine amidotransferase of anthranilate synthase
C5B74_RS06075	COG0174	glutamine synthetase
C5B74_RS06085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C5B74_RS06120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5B74_RS06125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5B74_RS06130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5B74_RS06150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5B74_RS06155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5B74_RS06160	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C5B74_RS06175	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS06180	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5B74_RS06185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5B74_RS06195	COG2223	nitrite transmembrane transporter activity
C5B74_RS06205	COG0024	Methionine aminopeptidase
C5B74_RS06210	COG0052	Belongs to the universal ribosomal protein uS2 family
C5B74_RS06225	COG2207	Transcriptional regulator
C5B74_RS06250	COG2951	lytic endotransglycosylase activity
C5B74_RS06255	COG0772	Belongs to the SEDS family
C5B74_RS06270	COG0842	Transport permease protein
C5B74_RS06275	COG1131	(ABC) transporter
C5B74_RS06320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS06345	COG4215	(ABC) transporter
C5B74_RS06350	COG4160	amino acid transport
C5B74_RS06355	COG4598	ABC transporter
C5B74_RS06365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5B74_RS06370	COG0826	peptidase U32
C5B74_RS06375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B74_RS06390	COG1720	tRNA m6t6A37 methyltransferase activity
C5B74_RS06400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5B74_RS06415	COG0642	Histidine kinase
C5B74_RS06425	COG0494	nUDIX hydrolase
C5B74_RS06435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5B74_RS06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5B74_RS06445	COG3139	Protein of unknown function (DUF1315)
C5B74_RS06450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5B74_RS06460	COG1301	dicarboxylic acid transport
C5B74_RS06465	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS06470	COG2819	hydrolase of the alpha beta superfamily
C5B74_RS06480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5B74_RS06490	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5B74_RS06495	COG1234	tRNA 3'-trailer cleavage
C5B74_RS06525	COG2363	Small membrane protein
C5B74_RS06545	COG0513	Belongs to the DEAD box helicase family
C5B74_RS06555	COG0778	Nitroreductase
C5B74_RS06585	COG1286	toxin biosynthetic process
C5B74_RS06610	COG4783	chaperone-mediated protein folding
C5B74_RS06615	COG1610	YqeY-like protein
C5B74_RS06715	COG3111	PFAM Bacterial OB fold (BOF) protein
C5B74_RS06740	COG3243	poly(R)-hydroxyalkanoic acid synthase
C5B74_RS06745	COG0786	glutamate:sodium symporter activity
C5B74_RS06755	COG2186	Transcriptional regulator
C5B74_RS06805	COG0477	Major facilitator Superfamily
C5B74_RS06835	COG2985	domain, Protein
C5B74_RS06845	COG2995	paraquat-inducible protein a
C5B74_RS06850	COG3008	intermembrane lipid transfer
C5B74_RS06850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C5B74_RS06860	COG1794	racemase activity, acting on amino acids and derivatives
C5B74_RS06890	COG1301	dicarboxylic acid transport
C5B74_RS06900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B74_RS06905	COG2011	ABC-type metal ion transport system permease component
C5B74_RS06910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5B74_RS06915	COG1464	Belongs to the NlpA lipoprotein family
C5B74_RS06920	COG0151	Belongs to the GarS family
C5B74_RS06925	COG0138	bifunctional purine biosynthesis protein purh
C5B74_RS06930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C5B74_RS06960	COG2308	Evidence 4 Homologs of previously reported genes of
C5B74_RS06970	COG1305	Transglutaminase-like
C5B74_RS06980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5B74_RS06985	COG0305	Participates in initiation and elongation during chromosome replication
C5B74_RS07010	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5B74_RS07020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5B74_RS07025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5B74_RS07050	COG1649	PFAM Uncharacterised BCR, COG1649
C5B74_RS07050	COG0726	polysaccharide deacetylase
C5B74_RS07055	COG1215	transferase activity, transferring glycosyl groups
C5B74_RS07060	COG3658	cytochrome
C5B74_RS07070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B74_RS07090	COG0583	DNA-binding transcription factor activity
C5B74_RS07110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B74_RS07115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B74_RS07130	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS07135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B74_RS07140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B74_RS07165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C5B74_RS07170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C5B74_RS07180	COG2205	protein histidine kinase activity
C5B74_RS07185	COG0745	RESPONSE REGULATOR receiver
C5B74_RS07190	COG0174	glutamine synthetase
C5B74_RS07210	COG0729	surface antigen
C5B74_RS07240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5B74_RS07245	COG2814	Major facilitator Superfamily
C5B74_RS07260	COG0583	DNA-binding transcription factor activity
C5B74_RS07275	COG1187	pseudouridine synthase activity
C5B74_RS07295	COG0802	atpase or kinase
C5B74_RS07300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5B74_RS07310	COG1923	regulation of RNA biosynthetic process
C5B74_RS07315	COG0697	spore germination
C5B74_RS07330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5B74_RS07340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5B74_RS07345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5B74_RS07345	COG0519	Catalyzes the synthesis of GMP from XMP
C5B74_RS07350	COG4302	ethanolamine ammonia-lyase activity
C5B74_RS07355	COG4303	Ethanolamine ammonia lyase large subunit
C5B74_RS07360	COG0531	amino acid
C5B74_RS07380	COG1454	alcohol dehydrogenase
C5B74_RS07385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5B74_RS07395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C5B74_RS07415	COG0308	aminopeptidase N
C5B74_RS07425	COG4221	oxidoreductase activity
C5B74_RS07435	COG1605	Chorismate mutase
C5B74_RS07455	COG1309	transcriptional regulator
C5B74_RS07465	COG0668	transmembrane transport
C5B74_RS07495	COG4773	Receptor
C5B74_RS07515	COG0488	(ABC) transporter
C5B74_RS07520	COG0589	response to stress
C5B74_RS07535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5B74_RS07545	COG3135	benzoate transporter
C5B74_RS07550	COG1522	sequence-specific DNA binding
C5B74_RS07560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5B74_RS07565	COG0583	DNA-binding transcription factor activity
C5B74_RS07575	COG0183	Belongs to the thiolase family
C5B74_RS07585	COG2030	dehydratase
C5B74_RS07590	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B74_RS07605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5B74_RS07615	COG0824	Thioesterase
C5B74_RS07620	COG1454	alcohol dehydrogenase
C5B74_RS07630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5B74_RS07650	COG0069	glutamate synthase activity
C5B74_RS07670	COG2814	Major facilitator Superfamily
C5B74_RS07685	COG0511	ligase activity, forming carbon-carbon bonds
C5B74_RS07705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B74_RS07705	COG1116	anion transmembrane transporter activity
C5B74_RS07710	COG0745	RESPONSE REGULATOR receiver
C5B74_RS07720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B74_RS07720	COG2146	nitrite reductase [NAD(P)H] activity
C5B74_RS07725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B74_RS07730	COG0243	molybdopterin cofactor binding
C5B74_RS07740	COG0243	molybdopterin cofactor binding
C5B74_RS07745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5B74_RS07760	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5B74_RS07760	COG0315	cyclic pyranopterin monophosphate synthase activity
C5B74_RS07765	COG0303	'Molybdopterin
C5B74_RS07775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B74_RS07780	COG0697	spore germination
C5B74_RS07800	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C5B74_RS07805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5B74_RS07865	COG2204	response regulator
C5B74_RS07870	COG3852	Histidine kinase
C5B74_RS07895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5B74_RS07900	COG0575	Belongs to the CDS family
C5B74_RS07935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5B74_RS07950	COG2137	regulation of response to DNA damage stimulus
C5B74_RS07960	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5B74_RS07965	COG1011	Hydrolase
C5B74_RS07990	COG1522	sequence-specific DNA binding
C5B74_RS08000	COG1113	amino acid transport
C5B74_RS08015	COG0659	secondary active sulfate transmembrane transporter activity
C5B74_RS08060	COG1132	(ABC) transporter
C5B74_RS08110	COG0482	sulfurtransferase activity
C5B74_RS08125	COG0488	(ABC) transporter
C5B74_RS08130	COG3173	Aminoglycoside phosphotransferase
C5B74_RS08140	COG2433	Pfam Transposase IS66
C5B74_RS08185	COG5001	Diguanylate cyclase
C5B74_RS08185	COG3300	MHYT domain
C5B74_RS08205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5B74_RS08205	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C5B74_RS08205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5B74_RS08210	COG1105	Belongs to the carbohydrate kinase PfkB family
C5B74_RS08215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5B74_RS08215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5B74_RS08245	COG0024	Methionine aminopeptidase
C5B74_RS08250	COG0583	DNA-binding transcription factor activity
C5B74_RS08260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5B74_RS08265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5B74_RS08270	COG0517	IMP dehydrogenase activity
C5B74_RS08270	COG0516	GMP reductase activity
C5B74_RS08295	COG0552	protein localization to endoplasmic reticulum
C5B74_RS08305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C5B74_RS08320	COG4890	Cyd operon protein YbgT
C5B74_RS08325	COG1294	oxidase, subunit
C5B74_RS08340	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5B74_RS08350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5B74_RS08355	COG4774	siderophore transport
C5B74_RS08370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5B74_RS08375	COG0569	domain protein
C5B74_RS08380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5B74_RS08410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C5B74_RS08415	COG0542	response to heat
C5B74_RS08440	COG1902	pentaerythritol trinitrate reductase activity
C5B74_RS08440	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B74_RS08485	COG2323	membrane
C5B74_RS08490	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5B74_RS08500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5B74_RS08505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5B74_RS08510	COG0183	Belongs to the thiolase family
C5B74_RS08515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5B74_RS08520	COG0596	Alpha beta hydrolase
C5B74_RS08525	COG2271	Major facilitator Superfamily
C5B74_RS08530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B74_RS08535	COG3485	protocatechuate 3,4-dioxygenase
C5B74_RS08540	COG3485	protocatechuate 3,4-dioxygenase
C5B74_RS08545	COG0710	3-dehydroquinate dehydratase activity
C5B74_RS08550	COG3420	alginic acid biosynthetic process
C5B74_RS08555	COG3659	wide pore channel activity
C5B74_RS08560	COG4993	Dehydrogenase
C5B74_RS08570	COG2391	methyltransferase activity
C5B74_RS08585	COG1414	Transcriptional regulator
C5B74_RS08590	COG0583	DNA-binding transcription factor activity
C5B74_RS08595	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS08620	COG2814	Major facilitator Superfamily
C5B74_RS08630	COG0154	amidase activity
C5B74_RS08650	COG4638	Rieske (2fe-2S)
C5B74_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS08670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B74_RS08680	COG3733	amine oxidase
C5B74_RS08690	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS08700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5B74_RS08705	COG0183	Belongs to the thiolase family
C5B74_RS08710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5B74_RS08715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5B74_RS08725	COG4829	muconolactone delta-isomerase
C5B74_RS08730	COG4948	Mandelate Racemase Muconate Lactonizing
C5B74_RS08735	COG0583	DNA-binding transcription factor activity
C5B74_RS08745	COG2186	Transcriptional regulator
C5B74_RS08765	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS08785	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS08795	COG3829	transcription factor binding
C5B74_RS08805	COG3162	membrane
C5B74_RS08820	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS08835	COG0753	catalase activity
C5B74_RS08860	COG1846	Transcriptional regulator
C5B74_RS08865	COG1902	pentaerythritol trinitrate reductase activity
C5B74_RS08865	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B74_RS08875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5B74_RS08905	COG1309	transcriptional regulator
C5B74_RS08915	COG1335	isochorismatase
C5B74_RS08920	COG0583	DNA-binding transcription factor activity
C5B74_RS08930	COG0475	glutathione-regulated potassium exporter activity
C5B74_RS08930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5B74_RS08940	COG1473	amidohydrolase
C5B74_RS08955	COG2831	hemolysin activation secretion protein
C5B74_RS08960	COG3210	domain, Protein
C5B74_RS08990	COG2188	Transcriptional regulator
C5B74_RS09005	COG0583	DNA-binding transcription factor activity
C5B74_RS09035	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5B74_RS09055	COG1566	PFAM secretion protein HlyD family protein
C5B74_RS09070	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS09075	COG0129	dihydroxy-acid dehydratase activity
C5B74_RS09085	COG0583	DNA-binding transcription factor activity
C5B74_RS09090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5B74_RS09100	COG2084	Dehydrogenase
C5B74_RS09105	COG2207	Transcriptional regulator
C5B74_RS09120	COG1064	alcohol dehydrogenase
C5B74_RS09130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5B74_RS09135	COG1120	ATPase activity
C5B74_RS09155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5B74_RS09275	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C5B74_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS09345	COG2207	Transcriptional regulator
C5B74_RS09355	COG2205	protein histidine kinase activity
C5B74_RS09360	COG0745	RESPONSE REGULATOR receiver
C5B74_RS09365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS09370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B74_RS09375	COG1538	Outer membrane efflux protein
C5B74_RS09385	COG2072	flavoprotein involved in K transport
C5B74_RS09405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B74_RS09425	COG3539	Fimbrial protein
C5B74_RS09455	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C5B74_RS09465	COG0753	catalase activity
C5B74_RS09480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5B74_RS09545	COG3433	isochorismatase activity
C5B74_RS09545	COG1535	isochorismatase
C5B74_RS09550	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS09555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C5B74_RS09560	COG4149	molybdate abc transporter
C5B74_RS09565	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5B74_RS09575	COG4638	Rieske (2fe-2S)
C5B74_RS09580	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C5B74_RS09585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5B74_RS09585	COG0543	2 iron, 2 sulfur cluster binding
C5B74_RS09610	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS09625	COG2207	Transcriptional regulator
C5B74_RS09635	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS09640	COG2610	gluconate transmembrane transporter activity
C5B74_RS09650	COG0583	DNA-binding transcription factor activity
C5B74_RS09660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5B74_RS09665	COG2031	fatty acid transporter
C5B74_RS09670	COG0183	Belongs to the thiolase family
C5B74_RS09675	COG0583	DNA-binding transcription factor activity
C5B74_RS09680	COG0583	DNA-binding transcription factor activity
C5B74_RS09695	COG1027	Aspartate ammonia-lyase
C5B74_RS09705	COG0477	Major facilitator Superfamily
C5B74_RS09725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B74_RS09730	COG4521	taurine ABC transporter
C5B74_RS09745	COG2188	Transcriptional regulator
C5B74_RS09755	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5B74_RS09760	COG1733	regulation of RNA biosynthetic process
C5B74_RS09765	COG3708	Transcriptional regulator
C5B74_RS09765	COG2207	Transcriptional regulator
C5B74_RS09780	COG0730	response to heat
C5B74_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B74_RS09790	COG3453	Protein conserved in bacteria
C5B74_RS09800	COG3781	membrane
C5B74_RS09805	COG1063	alcohol dehydrogenase
C5B74_RS09815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5B74_RS09820	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5B74_RS09825	COG0022	dehydrogenase e1 component
C5B74_RS09830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5B74_RS09835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5B74_RS09850	COG3706	GGDEF domain
C5B74_RS09865	COG0133	tryptophan synthase activity
C5B74_RS09875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5B74_RS09910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5B74_RS09935	COG2226	methyltransferase
C5B74_RS09990	COG0842	Transport permease protein
C5B74_RS09995	COG0842	Transport permease protein
C5B74_RS10000	COG1131	(ABC) transporter
C5B74_RS10015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C5B74_RS10020	COG4773	Receptor
C5B74_RS10040	COG0730	response to heat
C5B74_RS10045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5B74_RS10065	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C5B74_RS10125	COG4264	IucA IucC family
C5B74_RS10130	COG4264	IucA IucC family
C5B74_RS10150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C5B74_RS10165	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS10170	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS10175	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5B74_RS10180	COG2207	Transcriptional regulator
C5B74_RS10185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5B74_RS10190	COG0776	regulation of translation
C5B74_RS10215	COG0822	iron-sulfur transferase activity
C5B74_RS10220	COG0316	Belongs to the HesB IscA family
C5B74_RS10250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5B74_RS10270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5B74_RS10275	COG0702	epimerase
C5B74_RS10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5B74_RS10320	COG0339	signal peptide processing
C5B74_RS10370	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C5B74_RS10375	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C5B74_RS10405	COG0776	regulation of translation
C5B74_RS10470	COG0084	hydrolase, TatD family'
C5B74_RS10490	COG1663	tetraacyldisaccharide 4'-kinase activity
C5B74_RS10495	COG1132	(ABC) transporter
C5B74_RS10505	COG0811	peptide transport
C5B74_RS10510	COG1475	DNA binding
C5B74_RS10515	COG1192	Involved in chromosome partitioning
C5B74_RS10525	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5B74_RS10540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5B74_RS10545	COG0191	fructose-bisphosphate aldolase activity
C5B74_RS10565	COG0424	maF-like protein
C5B74_RS10570	COG2850	peptidyl-arginine hydroxylation
C5B74_RS10580	COG0640	Transcriptional regulator
C5B74_RS10590	COG3619	membrane
C5B74_RS10595	COG3122	Protein conserved in bacteria
C5B74_RS10600	COG1132	(ABC) transporter
C5B74_RS10620	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5B74_RS10625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5B74_RS10635	COG0506	proline dehydrogenase activity
C5B74_RS10635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5B74_RS10635	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C5B74_RS10640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5B74_RS10655	COG3698	Phosphodiester glycosidase
C5B74_RS10665	COG2353	YceI-like domain
C5B74_RS10675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5B74_RS10720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C5B74_RS10720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C5B74_RS10745	COG3539	Fimbrial protein
C5B74_RS10750	COG3121	Chaperone
C5B74_RS10780	COG0697	spore germination
C5B74_RS10790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5B74_RS10800	COG0583	DNA-binding transcription factor activity
C5B74_RS10820	COG1309	transcriptional regulator
C5B74_RS10835	COG1522	sequence-specific DNA binding
C5B74_RS10845	COG1126	abc transporter atp-binding protein
C5B74_RS10850	COG0765	amino acid transport
C5B74_RS10855	COG0765	amino acid transport
C5B74_RS10885	COG1464	Belongs to the NlpA lipoprotein family
C5B74_RS10895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5B74_RS10900	COG2011	ABC-type metal ion transport system permease component
C5B74_RS10905	COG0012	GTP binding
C5B74_RS10930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5B74_RS10970	COG0386	Belongs to the glutathione peroxidase family
C5B74_RS10980	COG0436	Aminotransferase
C5B74_RS11020	COG3634	alkyl hydroperoxide reductase activity
C5B74_RS11035	COG0583	DNA-binding transcription factor activity
C5B74_RS11040	COG0798	PFAM Bile acid sodium symporter
C5B74_RS11045	COG0640	Transcriptional regulator
C5B74_RS11060	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5B74_RS11070	COG0583	DNA-binding transcription factor activity
C5B74_RS11080	COG1953	Uracil, thiamine, allantoin
C5B74_RS11090	COG2175	clavaminate synthase activity
C5B74_RS11095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B74_RS11100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C5B74_RS11105	COG4521	taurine ABC transporter
C5B74_RS11115	COG0477	Major facilitator Superfamily
C5B74_RS11140	COG1271	oxidase subunit
C5B74_RS11145	COG1294	oxidase, subunit
C5B74_RS11155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B74_RS11175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5B74_RS11195	COG3052	prosthetic group binding
C5B74_RS11200	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C5B74_RS11210	COG2814	Major facilitator Superfamily
C5B74_RS11230	COG1346	cytolysis
C5B74_RS11240	COG0583	DNA-binding transcription factor activity
C5B74_RS11245	COG0625	glutathione transferase activity
C5B74_RS11250	COG0625	glutathione transferase activity
C5B74_RS11255	COG0583	DNA-binding transcription factor activity
C5B74_RS11270	COG1045	serine acetyltransferase
C5B74_RS11275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C5B74_RS11280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5B74_RS11290	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS11305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5B74_RS11310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5B74_RS11315	COG1126	abc transporter atp-binding protein
C5B74_RS11320	COG0765	amino acid transport
C5B74_RS11325	COG0765	amino acid transport
C5B74_RS11345	COG0784	Response regulator, receiver
C5B74_RS11345	COG2205	protein histidine kinase activity
C5B74_RS11365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5B74_RS11385	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS11430	COG0583	DNA-binding transcription factor activity
C5B74_RS11450	COG0318	PFAM AMP-dependent synthetase and ligase
C5B74_RS11455	COG1309	transcriptional regulator
C5B74_RS11460	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS11465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5B74_RS11470	COG1024	Enoyl-CoA hydratase
C5B74_RS11475	COG4770	biotin carboxylase activity
C5B74_RS11485	COG0583	DNA-binding transcription factor activity
C5B74_RS11500	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS11510	COG2814	Major facilitator Superfamily
C5B74_RS11520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5B74_RS11525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5B74_RS11530	COG2814	Major facilitator Superfamily
C5B74_RS11535	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS11540	COG1024	Enoyl-CoA hydratase
C5B74_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS11550	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5B74_RS11555	COG0183	Belongs to the thiolase family
C5B74_RS11565	COG2814	Major facilitator Superfamily
C5B74_RS11575	COG1024	Enoyl-CoA hydratase
C5B74_RS11590	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS11595	COG2814	Major facilitator Superfamily
C5B74_RS11600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5B74_RS11605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5B74_RS11620	COG3842	ATPase activity
C5B74_RS11625	COG1840	ABC-type Fe3 transport system, periplasmic component
C5B74_RS11635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B74_RS11640	COG1414	Transcriptional regulator
C5B74_RS11650	COG0583	DNA-binding transcription factor activity
C5B74_RS11655	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5B74_RS11660	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS11670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C5B74_RS11680	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS11685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B74_RS11690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B74_RS11695	COG2267	carboxylic ester hydrolase activity
C5B74_RS11715	COG3038	cytochrome b561
C5B74_RS11720	COG0753	catalase activity
C5B74_RS11760	COG2050	protein possibly involved in aromatic compounds catabolism
C5B74_RS11770	COG3327	negative regulation of DNA-templated transcription, initiation
C5B74_RS11775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C5B74_RS11780	COG0183	Belongs to the thiolase family
C5B74_RS11785	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5B74_RS11790	COG1024	Enoyl-CoA hydratase
C5B74_RS11795	COG1024	Enoyl-CoA hydratase
C5B74_RS11800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5B74_RS11805	COG2151	metal-sulfur cluster biosynthetic enzyme
C5B74_RS11810	COG3396	Phenylacetate-CoA oxygenase
C5B74_RS11815	COG3460	Phenylacetate-CoA oxygenase
C5B74_RS11820	COG3396	Phenylacetate-CoA oxygenase
C5B74_RS11825	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS11825	COG2030	dehydratase
C5B74_RS11830	COG1760	l-serine dehydratase
C5B74_RS11835	COG0531	amino acid
C5B74_RS11840	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS11855	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B74_RS11865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5B74_RS11885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B74_RS11900	COG0789	Transcriptional regulator
C5B74_RS11915	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5B74_RS11930	COG2807	transmembrane transport
C5B74_RS11935	COG0590	tRNA wobble adenosine to inosine editing
C5B74_RS12055	COG1116	anion transmembrane transporter activity
C5B74_RS12060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5B74_RS12070	COG0864	Transcriptional regulator
C5B74_RS12090	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5B74_RS12095	COG0439	Biotin carboxylase
C5B74_RS12110	COG1063	alcohol dehydrogenase
C5B74_RS12120	COG1309	transcriptional regulator
C5B74_RS12145	COG0038	chloride channel
C5B74_RS12150	COG4770	biotin carboxylase activity
C5B74_RS12170	COG1914	H( )-stimulated, divalent metal cation uptake system
C5B74_RS12175	COG0583	DNA-binding transcription factor activity
C5B74_RS12230	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5B74_RS12250	COG2814	Major facilitator Superfamily
C5B74_RS12265	COG1560	Kdo2-lipid A biosynthetic process
C5B74_RS12275	COG5006	permease, DMT superfamily
C5B74_RS12280	COG1522	sequence-specific DNA binding
C5B74_RS12295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C5B74_RS12305	COG4122	O-methyltransferase activity
C5B74_RS12335	COG1538	Outer membrane efflux protein
C5B74_RS12340	COG1137	ATPase activity
C5B74_RS12345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C5B74_RS12355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C5B74_RS12360	COG0517	IMP dehydrogenase activity
C5B74_RS12360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5B74_RS12400	COG2814	Major facilitator Superfamily
C5B74_RS12440	COG1278	Cold shock
C5B74_RS12445	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS12480	COG1570	exodeoxyribonuclease VII activity
C5B74_RS12535	COG0583	DNA-binding transcription factor activity
C5B74_RS12540	COG4638	Rieske (2fe-2S)
C5B74_RS12545	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C5B74_RS12550	COG0633	Ferredoxin
C5B74_RS12550	COG0543	2 iron, 2 sulfur cluster binding
C5B74_RS12555	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS12560	COG3135	benzoate transporter
C5B74_RS12565	COG2814	Major facilitator Superfamily
C5B74_RS12580	COG1643	Atp-dependent helicase
C5B74_RS12585	COG0450	alkyl hydroperoxide reductase
C5B74_RS12595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C5B74_RS12605	COG3634	alkyl hydroperoxide reductase activity
C5B74_RS12625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5B74_RS12630	COG0625	glutathione transferase activity
C5B74_RS12640	COG2885	chlorophyll binding
C5B74_RS12675	COG0542	response to heat
C5B74_RS12690	COG1765	OsmC-like protein
C5B74_RS12700	COG0667	Aldo Keto reductase
C5B74_RS12715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5B74_RS12725	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5B74_RS12735	COG0527	aspartate kinase activity
C5B74_RS12745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5B74_RS12755	COG3038	cytochrome b561
C5B74_RS12760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C5B74_RS12765	COG2252	PERMEase
C5B74_RS12775	COG2072	flavoprotein involved in K transport
C5B74_RS12800	COG1309	transcriptional regulator
C5B74_RS12810	COG0300	oxidoreductase activity
C5B74_RS12940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5B74_RS12980	COG1113	amino acid transport
C5B74_RS13000	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS13020	COG0531	amino acid
C5B74_RS13030	COG1113	amino acid transport
C5B74_RS13075	COG3209	COG3209 Rhs family protein
C5B74_RS13100	COG4269	membrane
C5B74_RS13115	COG1902	pentaerythritol trinitrate reductase activity
C5B74_RS13115	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B74_RS13125	COG3706	GGDEF domain
C5B74_RS13125	COG2203	Gaf domain
C5B74_RS13125	COG5001	Diguanylate cyclase
C5B74_RS13125	COG4251	negative regulation of phosphorylation
C5B74_RS13135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5B74_RS13155	COG4172	Belongs to the ABC transporter superfamily
C5B74_RS13160	COG4239	(ABC) transporter, permease
C5B74_RS13165	COG4174	ABC transporter (Permease)
C5B74_RS13175	COG0741	lytic transglycosylase activity
C5B74_RS13175	COG1388	LysM domain
C5B74_RS13175	COG0741	lytic transglycosylase activity
C5B74_RS13175	COG1388	LysM domain
C5B74_RS13180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5B74_RS13220	COG0583	DNA-binding transcription factor activity
C5B74_RS13225	COG1279	arginine transmembrane transporter activity
C5B74_RS13245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B74_RS13250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B74_RS13255	COG0006	proline dipeptidase activity
C5B74_RS13290	COG2194	sulfuric ester hydrolase activity
C5B74_RS13335	COG0739	heme binding
C5B74_RS13660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5B74_RS13685	COG3384	dioxygenase
C5B74_RS13695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5B74_RS13700	COG2878	Part of a membrane complex involved in electron transport
C5B74_RS13705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5B74_RS13730	COG0768	penicillin binding
C5B74_RS13735	COG0742	ribosomal rna small subunit methyltransferase
C5B74_RS13750	COG0830	nickel cation binding
C5B74_RS13760	COG0804	urea catabolic process
C5B74_RS13800	COG1253	flavin adenine dinucleotide binding
C5B74_RS13810	COG2851	Citrate transporter
C5B74_RS13860	COG1773	rubredoxin
C5B74_RS13865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5B74_RS13875	COG0583	DNA-binding transcription factor activity
C5B74_RS13900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C5B74_RS13905	COG4181	ATPase activity
C5B74_RS13950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C5B74_RS13970	COG0306	phosphate transporter
C5B74_RS13980	COG3958	Transketolase
C5B74_RS13985	COG3959	Transketolase, thiamine diphosphate binding domain
C5B74_RS13990	COG2271	Major facilitator Superfamily
C5B74_RS13995	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS14000	COG0583	DNA-binding transcription factor activity
C5B74_RS14020	COG2223	nitrite transmembrane transporter activity
C5B74_RS14025	COG2207	Transcriptional regulator
C5B74_RS14030	COG2066	Belongs to the glutaminase family
C5B74_RS14035	COG0242	peptide deformylase activity
C5B74_RS14040	COG0477	Major facilitator Superfamily
C5B74_RS14050	COG0028	Belongs to the TPP enzyme family
C5B74_RS14065	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS14070	COG2267	carboxylic ester hydrolase activity
C5B74_RS14080	COG2271	Major facilitator Superfamily
C5B74_RS14085	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5B74_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS14115	COG1414	Transcriptional regulator
C5B74_RS14130	COG1024	Enoyl-CoA hydratase
C5B74_RS14140	COG1215	transferase activity, transferring glycosyl groups
C5B74_RS14145	COG1649	PFAM Uncharacterised BCR, COG1649
C5B74_RS14145	COG0726	polysaccharide deacetylase
C5B74_RS14155	COG4681	YaeQ
C5B74_RS14165	COG0523	cobalamin synthesis protein
C5B74_RS14175	COG1607	acyl-coa hydrolase
C5B74_RS14185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B74_RS14190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5B74_RS14195	COG1309	transcriptional regulator
C5B74_RS14220	COG2040	homocysteine
C5B74_RS14225	COG0531	amino acid
C5B74_RS14250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B74_RS14255	COG0477	Major facilitator Superfamily
C5B74_RS14315	COG0405	Gamma-glutamyltransferase
C5B74_RS14320	COG2814	Major facilitator Superfamily
C5B74_RS14330	COG2050	protein possibly involved in aromatic compounds catabolism
C5B74_RS14345	COG1090	epimerase
C5B74_RS14365	COG0420	3'-5' exonuclease activity
C5B74_RS14390	COG0735	belongs to the Fur family
C5B74_RS14395	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5B74_RS14420	COG0121	glutamine amidotransferase
C5B74_RS14435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B74_RS14445	COG0210	DNA helicase
C5B74_RS14450	COG2885	chlorophyll binding
C5B74_RS14455	COG0204	Acyl-transferase
C5B74_RS14470	COG2894	cell division
C5B74_RS14490	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS14495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5B74_RS14495	COG1674	ftsk spoiiie
C5B74_RS14500	COG0492	ferredoxin-NADP+ reductase activity
C5B74_RS14505	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C5B74_RS14515	COG0456	acetyltransferase
C5B74_RS14560	COG1981	membrane
C5B74_RS14575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5B74_RS14575	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5B74_RS14595	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS14605	COG0657	acetylesterase activity
C5B74_RS14615	COG0473	3-isopropylmalate dehydrogenase activity
C5B74_RS14620	COG0583	DNA-binding transcription factor activity
C5B74_RS14640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C5B74_RS14665	COG0564	pseudouridine synthase activity
C5B74_RS14675	COG0358	DNA primase activity
C5B74_RS14690	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C5B74_RS14720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5B74_RS14750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5B74_RS14760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5B74_RS14760	COG0352	thiamine-phosphate diphosphorylase activity
C5B74_RS14760	COG0351	phosphomethylpyrimidine kinase
C5B74_RS14765	COG1652	LysM domain
C5B74_RS14790	COG1399	metal-binding, possibly nucleic acid-binding protein
C5B74_RS14795	COG3101	peptidyl-lysine hydroxylation
C5B74_RS14800	COG0009	L-threonylcarbamoyladenylate synthase
C5B74_RS14805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5B74_RS14810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5B74_RS14825	COG4106	trans-aconitate 2-methyltransferase activity
C5B74_RS14840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5B74_RS14840	COG0596	Alpha beta hydrolase
C5B74_RS14840	COG2226	methyltransferase
C5B74_RS14845	COG1877	trehalose-phosphatase activity
C5B74_RS14850	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C5B74_RS14855	COG2223	nitrite transmembrane transporter activity
C5B74_RS14875	COG1196	nuclear chromosome segregation
C5B74_RS14885	COG0730	response to heat
C5B74_RS14900	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5B74_RS14910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5B74_RS14970	COG0489	protein tyrosine kinase activity
C5B74_RS14980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5B74_RS14980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5B74_RS15010	COG2515	1-aminocyclopropane-1-carboxylate deaminase
C5B74_RS15015	COG2081	HI0933 family
C5B74_RS15025	COG0668	transmembrane transport
C5B74_RS15045	COG0583	DNA-binding transcription factor activity
C5B74_RS15065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5B74_RS15070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5B74_RS15100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5B74_RS15140	COG0745	RESPONSE REGULATOR receiver
C5B74_RS15160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5B74_RS15170	COG2205	protein histidine kinase activity
C5B74_RS15250	COG4993	Dehydrogenase
C5B74_RS15270	COG0384	phenazine biosynthesis protein PhzF
C5B74_RS15300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5B74_RS15315	COG0583	DNA-binding transcription factor activity
C5B74_RS15345	COG0583	DNA-binding transcription factor activity
C5B74_RS15365	COG0583	DNA-binding transcription factor activity
C5B74_RS15370	COG1053	succinate dehydrogenase
C5B74_RS15380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5B74_RS15385	COG2814	Major facilitator Superfamily
C5B74_RS15390	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS15395	COG0583	DNA-binding transcription factor activity
C5B74_RS15400	COG1063	alcohol dehydrogenase
C5B74_RS15430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5B74_RS15435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C5B74_RS15440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5B74_RS15455	COG3667	copper resistance
C5B74_RS15460	COG2132	Multicopper oxidase
C5B74_RS15470	COG0561	phosphatase activity
C5B74_RS15475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5B74_RS15500	COG1214	PFAM Peptidase M22, glycoprotease
C5B74_RS15550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5B74_RS15560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5B74_RS15565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5B74_RS15570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5B74_RS15630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5B74_RS15640	COG1846	Transcriptional regulator
C5B74_RS15645	COG1764	response to oxidative stress
C5B74_RS15685	COG0037	tRNA processing
C5B74_RS15695	COG0248	Ppx GppA phosphatase
C5B74_RS15725	COG0072	phenylalanine-tRNA ligase activity
C5B74_RS15765	COG1238	metal cluster binding
C5B74_RS15770	COG0625	glutathione transferase activity
C5B74_RS15790	COG0318	PFAM AMP-dependent synthetase and ligase
C5B74_RS15795	COG3028	Belongs to the UPF0307 family
C5B74_RS15800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5B74_RS15820	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5B74_RS15825	COG0617	tRNA 3'-terminal CCA addition
C5B74_RS15830	COG1555	photosystem II stabilization
C5B74_RS15835	COG3956	TIGRFAM MazG family protein
C5B74_RS15845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5B74_RS15865	COG2205	protein histidine kinase activity
C5B74_RS15865	COG0784	Response regulator, receiver
C5B74_RS15865	COG5002	protein histidine kinase activity
C5B74_RS15870	COG1024	Enoyl-CoA hydratase
C5B74_RS15875	COG2084	Dehydrogenase
C5B74_RS15880	COG3622	Belongs to the hyi family
C5B74_RS15910	COG0697	spore germination
C5B74_RS15920	COG2814	Major facilitator Superfamily
C5B74_RS15925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5B74_RS15935	COG0583	DNA-binding transcription factor activity
C5B74_RS15945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5B74_RS15960	COG0084	hydrolase, TatD family'
C5B74_RS15975	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C5B74_RS16010	COG0440	acetolactate synthase activity
C5B74_RS16015	COG0028	Belongs to the TPP enzyme family
C5B74_RS16040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5B74_RS16045	COG1136	(ABC) transporter
C5B74_RS16045	COG0577	efflux transmembrane transporter activity
C5B74_RS16050	COG1538	Outer membrane efflux protein
C5B74_RS16065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5B74_RS16070	COG1162	GTPase activity
C5B74_RS16080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C5B74_RS16100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5B74_RS16105	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS16145	COG2986	histidine ammonia-lyase
C5B74_RS16160	COG0318	PFAM AMP-dependent synthetase and ligase
C5B74_RS16170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B74_RS16215	COG1426	Protein conserved in bacteria
C5B74_RS16250	COG0793	Belongs to the peptidase S41A family
C5B74_RS16265	COG2267	carboxylic ester hydrolase activity
C5B74_RS16275	COG1012	belongs to the aldehyde dehydrogenase family
C5B74_RS16280	COG3265	gluconokinase activity
C5B74_RS16290	COG0800	Aldolase
C5B74_RS16300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5B74_RS16305	COG0857	belongs to the CobB CobQ family
C5B74_RS16305	COG0280	phosphate acetyltransferase
C5B74_RS16310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C5B74_RS16310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C5B74_RS16330	COG0740	serine-type endopeptidase activity
C5B74_RS16340	COG4774	siderophore transport
C5B74_RS16350	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5B74_RS16360	COG2813	Specifically methylates the guanine in position
C5B74_RS16360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C5B74_RS16460	COG0788	formyltetrahydrofolate deformylase activity
C5B74_RS16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5B74_RS16485	COG4651	solute:proton antiporter activity
C5B74_RS16505	COG0724	RNA recognition motif
C5B74_RS16510	COG0210	DNA helicase
C5B74_RS16535	COG1733	regulation of RNA biosynthetic process
C5B74_RS16545	COG2900	Belongs to the SlyX family
C5B74_RS16550	COG0488	(ABC) transporter
C5B74_RS16555	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS16560	COG1560	Kdo2-lipid A biosynthetic process
C5B74_RS16570	COG1301	dicarboxylic acid transport
C5B74_RS16625	COG0473	3-isopropylmalate dehydrogenase activity
C5B74_RS16690	COG0583	DNA-binding transcription factor activity
C5B74_RS16700	COG0625	glutathione transferase activity
C5B74_RS16705	COG2378	regulation of single-species biofilm formation
C5B74_RS16710	COG0546	phosphoglycolate phosphatase activity
C5B74_RS16725	COG1530	ribonuclease E activity
C5B74_RS16730	COG0318	PFAM AMP-dependent synthetase and ligase
C5B74_RS16745	COG0583	DNA-binding transcription factor activity
C5B74_RS16750	COG4221	oxidoreductase activity
C5B74_RS16755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5B74_RS16765	COG0534	Mate efflux family protein
C5B74_RS16780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C5B74_RS16820	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C5B74_RS16825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5B74_RS16840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5B74_RS16850	COG0644	oxidoreductase
C5B74_RS16850	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C5B74_RS16855	COG0425	Belongs to the sulfur carrier protein TusA family
C5B74_RS16860	COG4535	Mg2 and Co2 transporter CorC
C5B74_RS16870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5B74_RS16890	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5B74_RS16895	COG0475	glutathione-regulated potassium exporter activity
C5B74_RS16895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5B74_RS16900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5B74_RS16910	COG0484	heat shock protein binding
C5B74_RS16915	COG0789	Transcriptional regulator
C5B74_RS16920	COG0598	Magnesium transport protein CorA
C5B74_RS16935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5B74_RS16940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5B74_RS16945	COG1074	ATP-dependent DNA helicase activity
C5B74_RS16950	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C5B74_RS16980	COG2226	methyltransferase
C5B74_RS16995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C5B74_RS17000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5B74_RS17015	COG2111	Na H antiporter
C5B74_RS17015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5B74_RS17020	COG1006	Multisubunit Na H antiporter MnhC subunit
C5B74_RS17025	COG0651	ATP synthesis coupled electron transport
C5B74_RS17030	COG1863	multisubunit Na H antiporter MnhE subunit
C5B74_RS17035	COG2212	antiporter activity
C5B74_RS17040	COG1320	monovalent cation:proton antiporter activity
C5B74_RS17055	COG0195	Participates in both transcription termination and antitermination
C5B74_RS17105	COG0237	dephospho-CoA kinase activity
C5B74_RS17115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5B74_RS17130	COG0497	DNA recombination
C5B74_RS17140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5B74_RS17170	COG2169	Transcriptional regulator
C5B74_RS17170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5B74_RS17175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5B74_RS17245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C5B74_RS17260	COG0326	Molecular chaperone. Has ATPase activity
C5B74_RS17275	COG2056	Na+-H+ antiporter family
C5B74_RS17280	COG0596	Alpha beta hydrolase
C5B74_RS17375	COG0546	phosphoglycolate phosphatase activity
C5B74_RS17380	COG1716	ATPase activity
C5B74_RS17425	COG0181	hydroxymethylbilane synthase activity
C5B74_RS17435	COG3275	phosphorelay sensor kinase activity
C5B74_RS17455	COG1538	Outer membrane efflux protein
C5B74_RS17460	COG0697	spore germination
C5B74_RS17485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5B74_RS17490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5B74_RS17495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5B74_RS17500	COG0772	Belongs to the SEDS family
C5B74_RS17525	COG4974	Belongs to the 'phage' integrase family
C5B74_RS17530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5B74_RS17540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5B74_RS17550	COG2197	response regulator
C5B74_RS17565	COG0793	Belongs to the peptidase S41A family
C5B74_RS17570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5B74_RS17575	COG0795	lipopolysaccharide-transporting ATPase activity
C5B74_RS17615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5B74_RS17615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5B74_RS17625	COG0004	ammonium transporteR
C5B74_RS17630	COG0347	Belongs to the P(II) protein family
C5B74_RS17640	COG0606	chelatase, subunit chli
C5B74_RS17695	COG0659	secondary active sulfate transmembrane transporter activity
C5B74_RS17700	COG0589	response to stress
C5B74_RS17750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B74_RS17800	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C5B74_RS17830	COG0659	secondary active sulfate transmembrane transporter activity
C5B74_RS17835	COG0589	response to stress
C5B74_RS17865	COG0606	chelatase, subunit chli
C5B74_RS17870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5B74_RS17880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5B74_RS17895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5B74_RS17910	COG0318	PFAM AMP-dependent synthetase and ligase
C5B74_RS17920	COG0477	Major facilitator Superfamily
C5B74_RS17925	COG2860	membrane
C5B74_RS17935	COG1253	flavin adenine dinucleotide binding
C5B74_RS17955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5B74_RS17990	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5B74_RS18000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5B74_RS18035	COG1309	transcriptional regulator
C5B74_RS18070	COG0758	DNA mediated transformation
C5B74_RS18080	COG0697	spore germination
C5B74_RS18085	COG1309	transcriptional regulator
C5B74_RS18100	COG0386	Belongs to the glutathione peroxidase family
C5B74_RS18165	COG1121	(ABC) transporter
C5B74_RS18170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5B74_RS18175	COG1280	lysine exporter protein (LysE YggA)
C5B74_RS18180	COG2837	iron assimilation
C5B74_RS18190	COG0281	malic enzyme
C5B74_RS18235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5B74_RS18235	COG0519	Catalyzes the synthesis of GMP from XMP
C5B74_RS18240	COG4399	Belongs to the UPF0754 family
C5B74_RS18245	COG2259	Doxx family
C5B74_RS18250	COG0586	Pfam SNARE associated Golgi protein
C5B74_RS18265	COG1192	Involved in chromosome partitioning
C5B74_RS18275	COG0271	Belongs to the BolA IbaG family
C5B74_RS18295	COG2267	carboxylic ester hydrolase activity
C5B74_RS18315	COG3321	synthase
C5B74_RS18315	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C5B74_RS18315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C5B74_RS18315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5B74_RS18320	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS18330	COG2197	response regulator
C5B74_RS18340	COG3916	Acyl-homoserine-lactone synthase
C5B74_RS18345	COG0477	Major facilitator Superfamily
C5B74_RS18350	COG1024	Enoyl-CoA hydratase
C5B74_RS18355	COG1024	Enoyl-CoA hydratase
C5B74_RS18360	COG1960	acyl-CoA dehydrogenase activity
C5B74_RS18365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5B74_RS18385	COG1113	amino acid transport
C5B74_RS18390	COG1113	amino acid transport
C5B74_RS18395	COG0251	oxidation-reduction process
C5B74_RS18435	COG0564	pseudouridine synthase activity
C5B74_RS18500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5B74_RS18515	COG1802	Transcriptional regulator
C5B74_RS18525	COG1448	Aminotransferase
C5B74_RS18530	COG0277	FAD linked oxidase domain protein
C5B74_RS18540	COG2186	Transcriptional regulator
C5B74_RS18550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5B74_RS18555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5B74_RS18570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5B74_RS18580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5B74_RS18590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5B74_RS18595	COG0438	transferase activity, transferring glycosyl groups
C5B74_RS18615	COG1216	Glycosyl transferase, family 2
C5B74_RS18620	COG5039	Polysaccharide pyruvyl transferase
C5B74_RS18630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5B74_RS18635	COG1596	polysaccharide export
C5B74_RS18660	COG0728	peptidoglycan biosynthetic process
C5B74_RS18665	COG3023	N-Acetylmuramoyl-L-alanine amidase
C5B74_RS18720	COG0546	phosphoglycolate phosphatase activity
C5B74_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
C5B74_RS18745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B74_RS18750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5B74_RS18755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5B74_RS18760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5B74_RS18765	COG1116	anion transmembrane transporter activity
C5B74_RS18770	COG1309	transcriptional regulator
C5B74_RS18775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5B74_RS18785	COG0196	riboflavin kinase activity
C5B74_RS18790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5B74_RS18800	COG1047	Peptidyl-prolyl cis-trans
C5B74_RS18840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5B74_RS18845	COG0657	acetylesterase activity
C5B74_RS18895	COG2951	lytic endotransglycosylase activity
C5B74_RS18900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5B74_RS18920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5B74_RS18930	COG0671	phosphoesterase, PA-phosphatase related
C5B74_RS18935	COG0861	Integral membrane protein TerC family
C5B74_RS18945	COG0754	glutathionylspermidine amidase activity
C5B74_RS18955	COG0402	S-adenosylhomocysteine deaminase activity
C5B74_RS18970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5B74_RS18975	COG1230	cation diffusion facilitator family transporter
C5B74_RS18990	COG0706	membrane insertase activity