locus-tag	class	description
AYR70_RS00010	COG0592	DNA-directed DNA polymerase activity
AYR70_RS00020	COG0187	DNA topoisomerase II activity
AYR70_RS00030	COG0586	Pfam SNARE associated Golgi protein
AYR70_RS00035	COG0488	(ABC) transporter
AYR70_RS00060	COG0596	Alpha beta hydrolase
AYR70_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AYR70_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYR70_RS00115	COG0733	neurotransmitter:sodium symporter activity
AYR70_RS00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AYR70_RS00155	COG2233	PERMEase
AYR70_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS00205	COG2814	Major facilitator Superfamily
AYR70_RS00210	COG0656	L-ascorbic acid biosynthetic process
AYR70_RS00215	COG0583	DNA-binding transcription factor activity
AYR70_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR70_RS00230	COG1064	alcohol dehydrogenase
AYR70_RS00235	COG2818	Glycosylase
AYR70_RS00250	COG1194	a g-specific adenine glycosylase
AYR70_RS00270	COG2983	Belongs to the UPF0260 family
AYR70_RS00275	COG2133	pyrroloquinoline quinone binding
AYR70_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR70_RS00285	COG2116	formate transmembrane transporter activity
AYR70_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR70_RS00310	COG1335	isochorismatase
AYR70_RS00315	COG0385	Bile acid
AYR70_RS00320	COG0534	Mate efflux family protein
AYR70_RS00325	COG1683	Conserved Protein
AYR70_RS00345	COG0625	glutathione transferase activity
AYR70_RS00355	COG1113	amino acid transport
AYR70_RS00365	COG0523	cobalamin synthesis protein
AYR70_RS00375	COG2188	Transcriptional regulator
AYR70_RS00405	COG0010	Belongs to the arginase family
AYR70_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR70_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYR70_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYR70_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYR70_RS00540	COG0534	Mate efflux family protein
AYR70_RS00545	COG0436	Aminotransferase
AYR70_RS00550	COG2733	membrane
AYR70_RS00565	COG2918	glutathione biosynthetic process
AYR70_RS00580	COG0791	NLP P60 protein
AYR70_RS00580	COG1388	LysM domain
AYR70_RS00595	COG3150	esterase
AYR70_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AYR70_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR70_RS00630	COG2233	PERMEase
AYR70_RS00635	COG2351	hydroxyisourate hydrolase activity
AYR70_RS00670	COG3706	GGDEF domain
AYR70_RS00685	COG1393	Belongs to the ArsC family
AYR70_RS00690	COG0708	Exodeoxyribonuclease III
AYR70_RS00710	COG0189	ligase activity
AYR70_RS00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYR70_RS00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYR70_RS00755	COG4942	peptidase
AYR70_RS00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR70_RS00775	COG2119	membrane
AYR70_RS00780	COG4774	siderophore transport
AYR70_RS00785	COG0426	domain, Protein
AYR70_RS00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR70_RS00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYR70_RS00830	COG1902	pentaerythritol trinitrate reductase activity
AYR70_RS00835	COG1519	Transferase
AYR70_RS00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR70_RS00845	COG0668	transmembrane transport
AYR70_RS00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR70_RS00860	COG1335	isochorismatase
AYR70_RS00865	COG1522	sequence-specific DNA binding
AYR70_RS00870	COG3328	transposase activity
AYR70_RS00895	COG2205	protein histidine kinase activity
AYR70_RS00895	COG2198	Histidine kinase
AYR70_RS00895	COG0784	Response regulator, receiver
AYR70_RS00900	COG3162	membrane
AYR70_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR70_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR70_RS00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYR70_RS00940	COG1309	transcriptional regulator
AYR70_RS00960	COG0351	phosphomethylpyrimidine kinase
AYR70_RS00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR70_RS00960	COG0352	thiamine-phosphate diphosphorylase activity
AYR70_RS00970	COG2814	Major facilitator Superfamily
AYR70_RS00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR70_RS00995	COG1113	amino acid transport
AYR70_RS01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR70_RS01010	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS01020	COG1335	isochorismatase
AYR70_RS01050	COG2814	Major facilitator Superfamily
AYR70_RS01055	COG0583	DNA-binding transcription factor activity
AYR70_RS01075	COG0667	Aldo Keto reductase
AYR70_RS01105	COG1733	regulation of RNA biosynthetic process
AYR70_RS01110	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR70_RS01175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AYR70_RS01190	COG2329	Antibiotic biosynthesis monooxygenase
AYR70_RS01220	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYR70_RS01250	COG0427	acetyl-CoA hydrolase
AYR70_RS01270	COG0659	secondary active sulfate transmembrane transporter activity
AYR70_RS01275	COG4221	oxidoreductase activity
AYR70_RS01280	COG2873	o-acetylhomoserine
AYR70_RS01285	COG0488	(ABC) transporter
AYR70_RS01365	COG0833	amino acid
AYR70_RS01410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYR70_RS01415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYR70_RS01430	COG2226	methyltransferase
AYR70_RS01480	COG0069	glutamate synthase activity
AYR70_RS01480	COG0070	glutamate synthase
AYR70_RS01480	COG0067	glutamate synthase
AYR70_RS01485	COG0493	'glutamate synthase
AYR70_RS01495	COG1704	LemA family
AYR70_RS01500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AYR70_RS01520	COG3307	-O-antigen
AYR70_RS01540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR70_RS01550	COG0194	GDP metabolic process
AYR70_RS01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYR70_RS01620	COG5380	lipid catabolic process
AYR70_RS01625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYR70_RS01650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYR70_RS01655	COG0277	FAD linked oxidase domain protein
AYR70_RS01665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AYR70_RS01670	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR70_RS01685	COG1289	transmembrane transporter activity
AYR70_RS01695	COG0628	permease
AYR70_RS01700	COG1192	Involved in chromosome partitioning
AYR70_RS01730	COG0833	amino acid
AYR70_RS01735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR70_RS01740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR70_RS01750	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS01790	COG0583	DNA-binding transcription factor activity
AYR70_RS01835	COG0517	IMP dehydrogenase activity
AYR70_RS01840	COG1983	PspC domain protein
AYR70_RS01850	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS01865	COG0408	coproporphyrinogen oxidase activity
AYR70_RS01885	COG0513	Belongs to the DEAD box helicase family
AYR70_RS01895	COG1127	ABC transporter
AYR70_RS01900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYR70_RS01910	COG2854	intermembrane phospholipid transfer
AYR70_RS01920	COG0598	Magnesium transport protein CorA
AYR70_RS01930	COG0494	nUDIX hydrolase
AYR70_RS01935	COG1040	competence protein
AYR70_RS01940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYR70_RS01960	COG1946	Acyl-CoA thioesterase
AYR70_RS01965	COG1301	dicarboxylic acid transport
AYR70_RS01980	COG1959	2 iron, 2 sulfur cluster binding
AYR70_RS01985	COG1017	nitric oxide dioxygenase activity
AYR70_RS01985	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR70_RS01990	COG0433	COG0433 Predicted ATPase
AYR70_RS01995	COG0626	cystathionine gamma-synthase activity
AYR70_RS02150	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS02155	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AYR70_RS02185	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AYR70_RS02190	COG0339	signal peptide processing
AYR70_RS02195	COG0557	exoribonuclease II activity
AYR70_RS02240	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYR70_RS02245	COG2169	Transcriptional regulator
AYR70_RS02250	COG0697	spore germination
AYR70_RS02255	COG1295	ribonuclease BN
AYR70_RS02290	COG1702	phosphate starvation-inducible protein PhoH
AYR70_RS02300	COG0741	lytic transglycosylase activity
AYR70_RS02300	COG0739	heme binding
AYR70_RS02300	COG1196	nuclear chromosome segregation
AYR70_RS02330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AYR70_RS02335	COG1183	phosphatidylcholine synthase activity
AYR70_RS02380	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS02385	COG1309	transcriptional regulator
AYR70_RS02400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR70_RS02405	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS02425	COG2969	positive regulation of protein catabolic process
AYR70_RS02435	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYR70_RS02450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYR70_RS02455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AYR70_RS02475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYR70_RS02485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR70_RS02490	COG1408	metallophosphoesterase
AYR70_RS02500	COG2199	diguanylate cyclase activity
AYR70_RS02560	COG1607	acyl-coa hydrolase
AYR70_RS02590	COG2350	Protein conserved in bacteria
AYR70_RS02600	COG0613	PHP domain protein
AYR70_RS02605	COG3781	membrane
AYR70_RS02615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYR70_RS02620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYR70_RS02630	COG1862	Preprotein translocase
AYR70_RS02675	COG2205	protein histidine kinase activity
AYR70_RS02680	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYR70_RS02700	COG0726	polysaccharide deacetylase
AYR70_RS02705	COG0463	Glycosyl transferase, family 2
AYR70_RS02710	COG0438	transferase activity, transferring glycosyl groups
AYR70_RS02775	COG0625	glutathione transferase activity
AYR70_RS02780	COG0583	DNA-binding transcription factor activity
AYR70_RS02785	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS02790	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS02800	COG2205	protein histidine kinase activity
AYR70_RS02805	COG0745	RESPONSE REGULATOR receiver
AYR70_RS02810	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYR70_RS02830	COG2096	Adenosyltransferase
AYR70_RS02880	COG0285	dihydrofolate synthase activity
AYR70_RS02900	COG0450	alkyl hydroperoxide reductase
AYR70_RS02915	COG0477	Major facilitator Superfamily
AYR70_RS02920	COG1272	protein, Hemolysin III
AYR70_RS02950	COG0183	Belongs to the thiolase family
AYR70_RS02955	COG2207	Transcriptional regulator
AYR70_RS02975	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR70_RS02995	COG0183	Belongs to the thiolase family
AYR70_RS03005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYR70_RS03005	COG2885	chlorophyll binding
AYR70_RS03015	COG1690	Belongs to the RtcB family
AYR70_RS03020	COG0833	amino acid
AYR70_RS03030	COG2233	PERMEase
AYR70_RS03035	COG1217	gtp-binding protein TYPA
AYR70_RS03060	COG2094	Belongs to the DNA glycosylase MPG family
AYR70_RS03065	COG4772	TonB-dependent receptor
AYR70_RS03080	COG4772	TonB-dependent receptor
AYR70_RS03085	COG1902	pentaerythritol trinitrate reductase activity
AYR70_RS03090	COG0679	Auxin Efflux Carrier
AYR70_RS03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR70_RS03105	COG0354	folic acid binding
AYR70_RS03115	COG3189	MarR family transcriptional regulator
AYR70_RS03120	COG2824	Alkylphosphonate utilization operon protein PhnA
AYR70_RS03125	COG3422	double-strand break repair
AYR70_RS03165	COG0840	transmembrane signaling receptor activity
AYR70_RS03185	COG5510	response to toxic substance
AYR70_RS03195	COG2832	Protein of unknown function (DUF454)
AYR70_RS03200	COG1376	ErfK ybiS ycfS ynhG family protein
AYR70_RS03240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYR70_RS03250	COG1289	transmembrane transporter activity
AYR70_RS03255	COG2814	Major facilitator Superfamily
AYR70_RS03270	COG1115	amino acid carrier protein
AYR70_RS03275	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR70_RS03280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR70_RS03285	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AYR70_RS03315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR70_RS03325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR70_RS03330	COG1077	Cell shape determining protein MreB Mrl
AYR70_RS03335	COG1792	Involved in formation and maintenance of cell shape
AYR70_RS03340	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AYR70_RS03345	COG0424	maF-like protein
AYR70_RS03350	COG1530	ribonuclease E activity
AYR70_RS03360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR70_RS03370	COG0560	Phosphoserine phosphatase
AYR70_RS03380	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR70_RS03405	COG2207	Transcriptional regulator
AYR70_RS03425	COG1113	amino acid transport
AYR70_RS03430	COG2828	Protein conserved in bacteria
AYR70_RS03435	COG0142	geranyltranstransferase activity
AYR70_RS03440	COG2315	Protein conserved in bacteria
AYR70_RS03455	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR70_RS03475	COG2194	sulfuric ester hydrolase activity
AYR70_RS03480	COG0745	RESPONSE REGULATOR receiver
AYR70_RS03485	COG0642	Histidine kinase
AYR70_RS03495	COG0004	ammonium transporteR
AYR70_RS03500	COG0583	DNA-binding transcription factor activity
AYR70_RS03520	COG0525	valine-tRNA ligase activity
AYR70_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS03540	COG0393	Putative heavy-metal-binding
AYR70_RS03545	COG0393	Putative heavy-metal-binding
AYR70_RS03550	COG1538	Outer membrane efflux protein
AYR70_RS03560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS03565	COG0671	phosphoesterase, PA-phosphatase related
AYR70_RS03595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AYR70_RS03610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYR70_RS03610	COG1648	precorrin-2 dehydrogenase activity
AYR70_RS03615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYR70_RS03620	COG1733	regulation of RNA biosynthetic process
AYR70_RS03630	COG0531	amino acid
AYR70_RS03645	COG0321	lipoyl(octanoyl) transferase activity
AYR70_RS03650	COG2921	Belongs to the UPF0250 family
AYR70_RS03690	COG2009	succinate dehydrogenase
AYR70_RS03695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AYR70_RS03700	COG1053	succinate dehydrogenase
AYR70_RS03705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYR70_RS03720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR70_RS03740	COG2354	Protein conserved in bacteria
AYR70_RS03745	COG2321	neutral zinc metallopeptidase
AYR70_RS03770	COG2843	Capsule synthesis protein
AYR70_RS03785	COG0589	response to stress
AYR70_RS03805	COG0505	Belongs to the CarA family
AYR70_RS03830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR70_RS03835	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYR70_RS03885	COG0477	Major facilitator Superfamily
AYR70_RS03890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYR70_RS03905	COG1597	lipid kinase activity
AYR70_RS03910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR70_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR70_RS03940	COG0584	glycerophosphoryl diester phosphodiesterase
AYR70_RS03960	COG0741	lytic transglycosylase activity
AYR70_RS03980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYR70_RS03995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR70_RS04020	COG0778	Nitroreductase
AYR70_RS04035	COG1929	Belongs to the glycerate kinase type-1 family
AYR70_RS04040	COG0243	molybdopterin cofactor binding
AYR70_RS04045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYR70_RS04050	COG3339	Conserved Protein
AYR70_RS04060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AYR70_RS04075	COG1113	amino acid transport
AYR70_RS04085	COG0019	diaminopimelate decarboxylase activity
AYR70_RS04095	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS04100	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYR70_RS04130	COG0463	Glycosyl transferase, family 2
AYR70_RS04150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS04180	COG4591	ABC-type transport system involved in lipoprotein release permease component
AYR70_RS04185	COG1136	(ABC) transporter
AYR70_RS04190	COG2333	competence protein COMEC
AYR70_RS04190	COG0658	competence protein
AYR70_RS04200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYR70_RS04200	COG0616	signal peptide processing
AYR70_RS04205	COG0596	Alpha beta hydrolase
AYR70_RS04210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYR70_RS04220	COG0628	permease
AYR70_RS04255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR70_RS04275	COG0823	Involved in the tonB-independent uptake of proteins
AYR70_RS04295	COG0824	Thioesterase
AYR70_RS04300	COG1473	amidohydrolase
AYR70_RS04320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYR70_RS04320	COG0047	phosphoribosylformylglycinamidine synthase activity
AYR70_RS04325	COG2814	Major facilitator Superfamily
AYR70_RS04340	COG1024	Enoyl-CoA hydratase
AYR70_RS04345	COG1056	cytidyltransferase-related domain
AYR70_RS04345	COG1051	belongs to the nudix hydrolase family
AYR70_RS04355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYR70_RS04370	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AYR70_RS04385	COG4625	pathogenesis
AYR70_RS04390	COG0583	DNA-binding transcription factor activity
AYR70_RS04395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AYR70_RS04400	COG4208	sulfate ABC transporter
AYR70_RS04405	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AYR70_RS04415	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AYR70_RS04420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYR70_RS04425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYR70_RS04445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR70_RS04460	COG0681	Belongs to the peptidase S26 family
AYR70_RS04475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYR70_RS04485	COG1381	Involved in DNA repair and RecF pathway recombination
AYR70_RS04490	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AYR70_RS04500	COG4221	oxidoreductase activity
AYR70_RS04525	COG0436	Aminotransferase
AYR70_RS04545	COG0556	nucleotide-excision repair
AYR70_RS04600	COG2070	2-Nitropropane dioxygenase
AYR70_RS04630	COG1215	transferase activity, transferring glycosyl groups
AYR70_RS04645	COG0415	Belongs to the DNA photolyase family
AYR70_RS04655	COG1252	NADH dehydrogenase
AYR70_RS04660	COG1686	Belongs to the peptidase S11 family
AYR70_RS04675	COG1187	pseudouridine synthase activity
AYR70_RS04695	COG0477	Major facilitator Superfamily
AYR70_RS04700	COG0583	DNA-binding transcription factor activity
AYR70_RS04705	COG1823	symporter activity
AYR70_RS04715	COG0612	Peptidase, M16
AYR70_RS04740	COG0352	thiamine-phosphate diphosphorylase activity
AYR70_RS04775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR70_RS04790	COG1309	transcriptional regulator
AYR70_RS04800	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR70_RS04805	COG0076	glutamate decarboxylase activity
AYR70_RS04815	COG1522	sequence-specific DNA binding
AYR70_RS04820	COG3961	Belongs to the TPP enzyme family
AYR70_RS04825	COG1113	amino acid transport
AYR70_RS04830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR70_RS04835	COG0573	inorganic phosphate transmembrane transporter activity
AYR70_RS04845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYR70_RS04850	COG0616	signal peptide processing
AYR70_RS04885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AYR70_RS04890	COG1686	Belongs to the peptidase S11 family
AYR70_RS04915	COG0583	DNA-binding transcription factor activity
AYR70_RS04920	COG1067	ATP-dependent peptidase activity
AYR70_RS04965	COG1966	Carbon starvation protein
AYR70_RS04970	COG2879	small protein
AYR70_RS05000	COG2508	Transcriptional regulator
AYR70_RS05000	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AYR70_RS05020	COG1113	amino acid transport
AYR70_RS05025	COG0583	DNA-binding transcription factor activity
AYR70_RS05030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR70_RS05035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR70_RS05045	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS05050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR70_RS05055	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYR70_RS05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR70_RS05090	COG2814	Major facilitator Superfamily
AYR70_RS05095	COG4948	Mandelate Racemase Muconate Lactonizing
AYR70_RS05105	COG1309	transcriptional regulator
AYR70_RS05120	COG1741	Belongs to the pirin family
AYR70_RS05130	COG2964	Protein conserved in bacteria
AYR70_RS05145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR70_RS05150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR70_RS05155	COG4605	iron ion homeostasis
AYR70_RS05160	COG4604	ABC transporter, ATP-binding protein
AYR70_RS05165	COG4607	ABC-type enterochelin transport system periplasmic component
AYR70_RS05170	COG4774	siderophore transport
AYR70_RS05180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR70_RS05185	COG1021	2,3-dihydroxybenzoate-AMP ligase
AYR70_RS05190	COG1535	isochorismatase
AYR70_RS05190	COG3433	isochorismatase activity
AYR70_RS05205	COG1132	(ABC) transporter
AYR70_RS05210	COG1132	(ABC) transporter
AYR70_RS05215	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AYR70_RS05225	COG1169	isochorismate synthase
AYR70_RS05240	COG3739	integral membrane protein
AYR70_RS05270	COG0302	gtp cyclohydrolase
AYR70_RS05280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYR70_RS05310	COG0308	aminopeptidase N
AYR70_RS05315	COG0512	Glutamine amidotransferase of anthranilate synthase
AYR70_RS05330	COG0174	glutamine synthetase
AYR70_RS05340	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYR70_RS05375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYR70_RS05380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYR70_RS05385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR70_RS05405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR70_RS05410	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYR70_RS05415	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYR70_RS05430	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS05435	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR70_RS05440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR70_RS05455	COG2223	nitrite transmembrane transporter activity
AYR70_RS05465	COG0024	Methionine aminopeptidase
AYR70_RS05470	COG0052	Belongs to the universal ribosomal protein uS2 family
AYR70_RS05485	COG2207	Transcriptional regulator
AYR70_RS05510	COG2951	lytic endotransglycosylase activity
AYR70_RS05515	COG0772	Belongs to the SEDS family
AYR70_RS05530	COG0842	Transport permease protein
AYR70_RS05535	COG1131	(ABC) transporter
AYR70_RS05580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS05595	COG4215	(ABC) transporter
AYR70_RS05600	COG4160	amino acid transport
AYR70_RS05605	COG4598	ABC transporter
AYR70_RS05615	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR70_RS05620	COG0826	peptidase U32
AYR70_RS05625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR70_RS05640	COG1720	tRNA m6t6A37 methyltransferase activity
AYR70_RS05650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYR70_RS05665	COG0642	Histidine kinase
AYR70_RS05675	COG0494	nUDIX hydrolase
AYR70_RS05685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR70_RS05690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYR70_RS05695	COG3139	Protein of unknown function (DUF1315)
AYR70_RS05700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYR70_RS05705	COG1301	dicarboxylic acid transport
AYR70_RS05710	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS05715	COG2819	hydrolase of the alpha beta superfamily
AYR70_RS05725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYR70_RS05735	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYR70_RS05740	COG1234	tRNA 3'-trailer cleavage
AYR70_RS05770	COG2363	Small membrane protein
AYR70_RS05790	COG0513	Belongs to the DEAD box helicase family
AYR70_RS05800	COG0778	Nitroreductase
AYR70_RS05830	COG1286	toxin biosynthetic process
AYR70_RS05855	COG4783	chaperone-mediated protein folding
AYR70_RS05860	COG1610	YqeY-like protein
AYR70_RS05960	COG3111	PFAM Bacterial OB fold (BOF) protein
AYR70_RS05985	COG3243	poly(R)-hydroxyalkanoic acid synthase
AYR70_RS05990	COG0786	glutamate:sodium symporter activity
AYR70_RS06000	COG2186	Transcriptional regulator
AYR70_RS06050	COG0477	Major facilitator Superfamily
AYR70_RS06075	COG2985	domain, Protein
AYR70_RS06085	COG2995	paraquat-inducible protein a
AYR70_RS06090	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYR70_RS06090	COG3008	intermembrane lipid transfer
AYR70_RS06100	COG1794	racemase activity, acting on amino acids and derivatives
AYR70_RS06195	COG0488	(ABC) transporter
AYR70_RS06200	COG3173	Aminoglycoside phosphotransferase
AYR70_RS06210	COG2433	Pfam Transposase IS66
AYR70_RS06250	COG1301	dicarboxylic acid transport
AYR70_RS06260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR70_RS06265	COG2011	ABC-type metal ion transport system permease component
AYR70_RS06270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR70_RS06275	COG1464	Belongs to the NlpA lipoprotein family
AYR70_RS06280	COG0151	Belongs to the GarS family
AYR70_RS06285	COG0138	bifunctional purine biosynthesis protein purh
AYR70_RS06290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AYR70_RS06320	COG2308	Evidence 4 Homologs of previously reported genes of
AYR70_RS06330	COG1305	Transglutaminase-like
AYR70_RS06340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYR70_RS06345	COG0305	Participates in initiation and elongation during chromosome replication
AYR70_RS06370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AYR70_RS06380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYR70_RS06385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYR70_RS06410	COG1649	PFAM Uncharacterised BCR, COG1649
AYR70_RS06410	COG0726	polysaccharide deacetylase
AYR70_RS06415	COG1215	transferase activity, transferring glycosyl groups
AYR70_RS06420	COG3658	cytochrome
AYR70_RS06430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR70_RS06445	COG0583	DNA-binding transcription factor activity
AYR70_RS06465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR70_RS06470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR70_RS06485	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS06490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR70_RS06495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR70_RS06520	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYR70_RS06525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AYR70_RS06535	COG2205	protein histidine kinase activity
AYR70_RS06540	COG0745	RESPONSE REGULATOR receiver
AYR70_RS06545	COG0174	glutamine synthetase
AYR70_RS06565	COG0729	surface antigen
AYR70_RS06590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR70_RS06595	COG2814	Major facilitator Superfamily
AYR70_RS06610	COG0583	DNA-binding transcription factor activity
AYR70_RS06625	COG1187	pseudouridine synthase activity
AYR70_RS06645	COG0802	atpase or kinase
AYR70_RS06650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYR70_RS06660	COG1923	regulation of RNA biosynthetic process
AYR70_RS06665	COG0697	spore germination
AYR70_RS06680	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR70_RS06690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR70_RS06695	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR70_RS06695	COG0519	Catalyzes the synthesis of GMP from XMP
AYR70_RS06700	COG4302	ethanolamine ammonia-lyase activity
AYR70_RS06705	COG4303	Ethanolamine ammonia lyase large subunit
AYR70_RS06710	COG0531	amino acid
AYR70_RS06730	COG1454	alcohol dehydrogenase
AYR70_RS06735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR70_RS06745	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AYR70_RS06765	COG0308	aminopeptidase N
AYR70_RS06775	COG4221	oxidoreductase activity
AYR70_RS06785	COG1605	Chorismate mutase
AYR70_RS06800	COG1309	transcriptional regulator
AYR70_RS06810	COG0668	transmembrane transport
AYR70_RS06850	COG4773	Receptor
AYR70_RS06870	COG0488	(ABC) transporter
AYR70_RS06875	COG0589	response to stress
AYR70_RS06895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYR70_RS06905	COG3135	benzoate transporter
AYR70_RS06910	COG1522	sequence-specific DNA binding
AYR70_RS06920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYR70_RS06925	COG0583	DNA-binding transcription factor activity
AYR70_RS06935	COG0183	Belongs to the thiolase family
AYR70_RS06945	COG2030	dehydratase
AYR70_RS06950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR70_RS06965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYR70_RS06975	COG0824	Thioesterase
AYR70_RS06980	COG1454	alcohol dehydrogenase
AYR70_RS06990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYR70_RS07010	COG0069	glutamate synthase activity
AYR70_RS07185	COG5410	chromosome segregation
AYR70_RS07305	COG0739	heme binding
AYR70_RS07310	COG3328	transposase activity
AYR70_RS07410	COG2814	Major facilitator Superfamily
AYR70_RS07425	COG0511	ligase activity, forming carbon-carbon bonds
AYR70_RS07440	COG1116	anion transmembrane transporter activity
AYR70_RS07440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR70_RS07445	COG0745	RESPONSE REGULATOR receiver
AYR70_RS07455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR70_RS07455	COG2146	nitrite reductase [NAD(P)H] activity
AYR70_RS07460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR70_RS07465	COG0243	molybdopterin cofactor binding
AYR70_RS07475	COG0243	molybdopterin cofactor binding
AYR70_RS07480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AYR70_RS07495	COG0315	cyclic pyranopterin monophosphate synthase activity
AYR70_RS07495	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYR70_RS07500	COG0303	'Molybdopterin
AYR70_RS07510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR70_RS07515	COG0697	spore germination
AYR70_RS07535	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AYR70_RS07540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR70_RS07595	COG2204	response regulator
AYR70_RS07600	COG3852	Histidine kinase
AYR70_RS07620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYR70_RS07625	COG0575	Belongs to the CDS family
AYR70_RS07660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR70_RS07675	COG2137	regulation of response to DNA damage stimulus
AYR70_RS07685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYR70_RS07690	COG1011	Hydrolase
AYR70_RS07715	COG1522	sequence-specific DNA binding
AYR70_RS07725	COG1113	amino acid transport
AYR70_RS07740	COG0659	secondary active sulfate transmembrane transporter activity
AYR70_RS07745	COG2135	peptidase activity
AYR70_RS07760	COG5001	Diguanylate cyclase
AYR70_RS07760	COG3300	MHYT domain
AYR70_RS07780	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AYR70_RS07780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR70_RS07780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR70_RS07785	COG1105	Belongs to the carbohydrate kinase PfkB family
AYR70_RS07790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYR70_RS07790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR70_RS07820	COG0024	Methionine aminopeptidase
AYR70_RS07825	COG0583	DNA-binding transcription factor activity
AYR70_RS07835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AYR70_RS07840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR70_RS07845	COG0517	IMP dehydrogenase activity
AYR70_RS07845	COG0516	GMP reductase activity
AYR70_RS07870	COG0552	protein localization to endoplasmic reticulum
AYR70_RS07880	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AYR70_RS07895	COG4890	Cyd operon protein YbgT
AYR70_RS07900	COG1294	oxidase, subunit
AYR70_RS07915	COG1585	Membrane protein implicated in regulation of membrane protease activity
AYR70_RS07925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYR70_RS07930	COG4774	siderophore transport
AYR70_RS07945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYR70_RS07950	COG0569	domain protein
AYR70_RS07955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR70_RS07985	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYR70_RS07990	COG0542	response to heat
AYR70_RS08015	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR70_RS08015	COG1902	pentaerythritol trinitrate reductase activity
AYR70_RS08060	COG2323	membrane
AYR70_RS08065	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AYR70_RS08075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR70_RS08080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR70_RS08085	COG0183	Belongs to the thiolase family
AYR70_RS08090	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYR70_RS08095	COG0596	Alpha beta hydrolase
AYR70_RS08100	COG2271	Major facilitator Superfamily
AYR70_RS08105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR70_RS08110	COG3485	protocatechuate 3,4-dioxygenase
AYR70_RS08115	COG3485	protocatechuate 3,4-dioxygenase
AYR70_RS08120	COG0710	3-dehydroquinate dehydratase activity
AYR70_RS08125	COG3420	alginic acid biosynthetic process
AYR70_RS08130	COG3659	wide pore channel activity
AYR70_RS08135	COG4993	Dehydrogenase
AYR70_RS08145	COG2391	methyltransferase activity
AYR70_RS08160	COG1414	Transcriptional regulator
AYR70_RS08165	COG0583	DNA-binding transcription factor activity
AYR70_RS08170	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS08195	COG2814	Major facilitator Superfamily
AYR70_RS08205	COG0154	amidase activity
AYR70_RS08225	COG4638	Rieske (2fe-2S)
AYR70_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS08245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR70_RS08255	COG3733	amine oxidase
AYR70_RS08265	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS08275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR70_RS08280	COG0183	Belongs to the thiolase family
AYR70_RS08285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR70_RS08290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR70_RS08300	COG4829	muconolactone delta-isomerase
AYR70_RS08305	COG4948	Mandelate Racemase Muconate Lactonizing
AYR70_RS08310	COG0583	DNA-binding transcription factor activity
AYR70_RS08320	COG2186	Transcriptional regulator
AYR70_RS08340	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS08360	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS08370	COG3829	transcription factor binding
AYR70_RS08380	COG3162	membrane
AYR70_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS08410	COG0753	catalase activity
AYR70_RS08435	COG1846	Transcriptional regulator
AYR70_RS08440	COG1902	pentaerythritol trinitrate reductase activity
AYR70_RS08440	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR70_RS08450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYR70_RS08480	COG1309	transcriptional regulator
AYR70_RS08490	COG1335	isochorismatase
AYR70_RS08495	COG0583	DNA-binding transcription factor activity
AYR70_RS08505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR70_RS08505	COG0475	glutathione-regulated potassium exporter activity
AYR70_RS08515	COG1473	amidohydrolase
AYR70_RS08525	COG2831	hemolysin activation secretion protein
AYR70_RS08530	COG3210	domain, Protein
AYR70_RS08560	COG2188	Transcriptional regulator
AYR70_RS08575	COG0583	DNA-binding transcription factor activity
AYR70_RS08605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR70_RS08625	COG1566	PFAM secretion protein HlyD family protein
AYR70_RS08640	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS08645	COG0129	dihydroxy-acid dehydratase activity
AYR70_RS08655	COG0583	DNA-binding transcription factor activity
AYR70_RS08660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYR70_RS08670	COG2084	Dehydrogenase
AYR70_RS08675	COG2207	Transcriptional regulator
AYR70_RS08690	COG1064	alcohol dehydrogenase
AYR70_RS08700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR70_RS08705	COG1120	ATPase activity
AYR70_RS08725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR70_RS08815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS08820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR70_RS08825	COG1538	Outer membrane efflux protein
AYR70_RS08835	COG2072	flavoprotein involved in K transport
AYR70_RS08855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR70_RS08875	COG3539	Fimbrial protein
AYR70_RS08910	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYR70_RS08920	COG0753	catalase activity
AYR70_RS08935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR70_RS08995	COG3433	isochorismatase activity
AYR70_RS08995	COG1535	isochorismatase
AYR70_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS09005	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AYR70_RS09010	COG4149	molybdate abc transporter
AYR70_RS09015	COG0725	ABC transporter, periplasmic molybdate-binding protein
AYR70_RS09025	COG4638	Rieske (2fe-2S)
AYR70_RS09030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR70_RS09035	COG0543	2 iron, 2 sulfur cluster binding
AYR70_RS09035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR70_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS09075	COG2207	Transcriptional regulator
AYR70_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS09095	COG2610	gluconate transmembrane transporter activity
AYR70_RS09105	COG0583	DNA-binding transcription factor activity
AYR70_RS09115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR70_RS09120	COG2031	fatty acid transporter
AYR70_RS09125	COG0183	Belongs to the thiolase family
AYR70_RS09130	COG0583	DNA-binding transcription factor activity
AYR70_RS09135	COG0583	DNA-binding transcription factor activity
AYR70_RS09150	COG1027	Aspartate ammonia-lyase
AYR70_RS09160	COG0477	Major facilitator Superfamily
AYR70_RS09180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR70_RS09185	COG4521	taurine ABC transporter
AYR70_RS09200	COG2188	Transcriptional regulator
AYR70_RS09210	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYR70_RS09215	COG1733	regulation of RNA biosynthetic process
AYR70_RS09220	COG2207	Transcriptional regulator
AYR70_RS09220	COG3708	Transcriptional regulator
AYR70_RS09235	COG0730	response to heat
AYR70_RS09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR70_RS09245	COG3453	Protein conserved in bacteria
AYR70_RS09255	COG3781	membrane
AYR70_RS09260	COG1063	alcohol dehydrogenase
AYR70_RS09270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR70_RS09275	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR70_RS09280	COG0022	dehydrogenase e1 component
AYR70_RS09285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYR70_RS09290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR70_RS09305	COG3706	GGDEF domain
AYR70_RS09320	COG0133	tryptophan synthase activity
AYR70_RS09330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR70_RS09365	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYR70_RS09390	COG2226	methyltransferase
AYR70_RS09445	COG0842	Transport permease protein
AYR70_RS09450	COG0842	Transport permease protein
AYR70_RS09455	COG1131	(ABC) transporter
AYR70_RS09470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR70_RS09475	COG4773	Receptor
AYR70_RS09490	COG3328	transposase activity
AYR70_RS09500	COG0730	response to heat
AYR70_RS09505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYR70_RS09525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AYR70_RS09540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR70_RS09580	COG4264	IucA IucC family
AYR70_RS09585	COG4264	IucA IucC family
AYR70_RS09605	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYR70_RS09620	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS09625	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS09630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR70_RS09635	COG2207	Transcriptional regulator
AYR70_RS09640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR70_RS09645	COG0776	regulation of translation
AYR70_RS09670	COG0822	iron-sulfur transferase activity
AYR70_RS09675	COG0316	Belongs to the HesB IscA family
AYR70_RS09705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYR70_RS09725	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR70_RS09730	COG0702	epimerase
AYR70_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYR70_RS09785	COG0339	signal peptide processing
AYR70_RS09830	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYR70_RS09835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AYR70_RS09865	COG0776	regulation of translation
AYR70_RS09930	COG0084	hydrolase, TatD family'
AYR70_RS09950	COG1663	tetraacyldisaccharide 4'-kinase activity
AYR70_RS09955	COG1132	(ABC) transporter
AYR70_RS09965	COG0811	peptide transport
AYR70_RS09970	COG1475	DNA binding
AYR70_RS09975	COG1192	Involved in chromosome partitioning
AYR70_RS09985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYR70_RS10000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR70_RS10005	COG0191	fructose-bisphosphate aldolase activity
AYR70_RS10025	COG0424	maF-like protein
AYR70_RS10030	COG2850	peptidyl-arginine hydroxylation
AYR70_RS10040	COG0640	Transcriptional regulator
AYR70_RS10050	COG3619	membrane
AYR70_RS10055	COG3122	Protein conserved in bacteria
AYR70_RS10060	COG1132	(ABC) transporter
AYR70_RS10080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYR70_RS10085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR70_RS10095	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR70_RS10095	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR70_RS10095	COG0506	proline dehydrogenase activity
AYR70_RS10100	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYR70_RS10115	COG3698	Phosphodiester glycosidase
AYR70_RS10125	COG2353	YceI-like domain
AYR70_RS10135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYR70_RS10180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYR70_RS10180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYR70_RS10205	COG3539	Fimbrial protein
AYR70_RS10210	COG3121	Chaperone
AYR70_RS10235	COG0697	spore germination
AYR70_RS10245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR70_RS10255	COG0583	DNA-binding transcription factor activity
AYR70_RS10275	COG1309	transcriptional regulator
AYR70_RS10290	COG1522	sequence-specific DNA binding
AYR70_RS10300	COG1126	abc transporter atp-binding protein
AYR70_RS10305	COG0765	amino acid transport
AYR70_RS10310	COG0765	amino acid transport
AYR70_RS10340	COG1464	Belongs to the NlpA lipoprotein family
AYR70_RS10350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR70_RS10355	COG2011	ABC-type metal ion transport system permease component
AYR70_RS10360	COG0012	GTP binding
AYR70_RS10385	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR70_RS10425	COG0386	Belongs to the glutathione peroxidase family
AYR70_RS10435	COG0436	Aminotransferase
AYR70_RS10475	COG3634	alkyl hydroperoxide reductase activity
AYR70_RS10490	COG0583	DNA-binding transcription factor activity
AYR70_RS10495	COG0798	PFAM Bile acid sodium symporter
AYR70_RS10500	COG0640	Transcriptional regulator
AYR70_RS10525	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AYR70_RS10535	COG0583	DNA-binding transcription factor activity
AYR70_RS10545	COG1953	Uracil, thiamine, allantoin
AYR70_RS10555	COG2175	clavaminate synthase activity
AYR70_RS10560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR70_RS10565	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AYR70_RS10570	COG4521	taurine ABC transporter
AYR70_RS10580	COG0477	Major facilitator Superfamily
AYR70_RS10600	COG1271	oxidase subunit
AYR70_RS10605	COG1294	oxidase, subunit
AYR70_RS10615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR70_RS10635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AYR70_RS10655	COG3052	prosthetic group binding
AYR70_RS10660	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AYR70_RS10670	COG2814	Major facilitator Superfamily
AYR70_RS10690	COG1346	cytolysis
AYR70_RS10700	COG0583	DNA-binding transcription factor activity
AYR70_RS10705	COG0625	glutathione transferase activity
AYR70_RS10710	COG0625	glutathione transferase activity
AYR70_RS10715	COG0583	DNA-binding transcription factor activity
AYR70_RS10730	COG1045	serine acetyltransferase
AYR70_RS10735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR70_RS10740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYR70_RS10745	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS10755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR70_RS10760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR70_RS10765	COG1126	abc transporter atp-binding protein
AYR70_RS10770	COG0765	amino acid transport
AYR70_RS10775	COG0765	amino acid transport
AYR70_RS10790	COG2205	protein histidine kinase activity
AYR70_RS10790	COG0784	Response regulator, receiver
AYR70_RS10810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR70_RS10830	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS10880	COG0583	DNA-binding transcription factor activity
AYR70_RS10900	COG0318	PFAM AMP-dependent synthetase and ligase
AYR70_RS10905	COG1309	transcriptional regulator
AYR70_RS10910	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS10915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR70_RS10920	COG1024	Enoyl-CoA hydratase
AYR70_RS10925	COG4770	biotin carboxylase activity
AYR70_RS10935	COG0583	DNA-binding transcription factor activity
AYR70_RS10950	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS10960	COG2814	Major facilitator Superfamily
AYR70_RS10970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR70_RS10975	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR70_RS10980	COG2814	Major facilitator Superfamily
AYR70_RS10985	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS10990	COG1024	Enoyl-CoA hydratase
AYR70_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS11000	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR70_RS11005	COG0183	Belongs to the thiolase family
AYR70_RS11015	COG2814	Major facilitator Superfamily
AYR70_RS11025	COG1024	Enoyl-CoA hydratase
AYR70_RS11040	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS11045	COG2814	Major facilitator Superfamily
AYR70_RS11050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR70_RS11055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYR70_RS11070	COG3842	ATPase activity
AYR70_RS11075	COG1840	ABC-type Fe3 transport system, periplasmic component
AYR70_RS11085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR70_RS11090	COG1414	Transcriptional regulator
AYR70_RS11100	COG0583	DNA-binding transcription factor activity
AYR70_RS11105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR70_RS11110	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS11120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR70_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS11130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR70_RS11135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR70_RS11140	COG2267	carboxylic ester hydrolase activity
AYR70_RS11160	COG3038	cytochrome b561
AYR70_RS11165	COG0753	catalase activity
AYR70_RS11200	COG2050	protein possibly involved in aromatic compounds catabolism
AYR70_RS11210	COG3327	negative regulation of DNA-templated transcription, initiation
AYR70_RS11215	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYR70_RS11220	COG0183	Belongs to the thiolase family
AYR70_RS11225	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR70_RS11230	COG1024	Enoyl-CoA hydratase
AYR70_RS11235	COG1024	Enoyl-CoA hydratase
AYR70_RS11240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR70_RS11245	COG2151	metal-sulfur cluster biosynthetic enzyme
AYR70_RS11250	COG3396	Phenylacetate-CoA oxygenase
AYR70_RS11255	COG3460	Phenylacetate-CoA oxygenase
AYR70_RS11260	COG3396	Phenylacetate-CoA oxygenase
AYR70_RS11265	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS11265	COG2030	dehydratase
AYR70_RS11270	COG1760	l-serine dehydratase
AYR70_RS11275	COG0531	amino acid
AYR70_RS11280	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS11295	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR70_RS11305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR70_RS11325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR70_RS11335	COG0789	Transcriptional regulator
AYR70_RS11355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYR70_RS11370	COG2807	transmembrane transport
AYR70_RS11375	COG0590	tRNA wobble adenosine to inosine editing
AYR70_RS11490	COG1116	anion transmembrane transporter activity
AYR70_RS11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR70_RS11505	COG0864	Transcriptional regulator
AYR70_RS11520	COG1733	regulation of RNA biosynthetic process
AYR70_RS11525	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR70_RS11530	COG0439	Biotin carboxylase
AYR70_RS11545	COG1063	alcohol dehydrogenase
AYR70_RS11555	COG1309	transcriptional regulator
AYR70_RS11580	COG0038	chloride channel
AYR70_RS11585	COG4770	biotin carboxylase activity
AYR70_RS11605	COG1914	H( )-stimulated, divalent metal cation uptake system
AYR70_RS11610	COG0583	DNA-binding transcription factor activity
AYR70_RS11655	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR70_RS11675	COG2814	Major facilitator Superfamily
AYR70_RS11685	COG1560	Kdo2-lipid A biosynthetic process
AYR70_RS11695	COG5006	permease, DMT superfamily
AYR70_RS11700	COG1522	sequence-specific DNA binding
AYR70_RS11715	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AYR70_RS11725	COG4122	O-methyltransferase activity
AYR70_RS11755	COG1538	Outer membrane efflux protein
AYR70_RS11760	COG1137	ATPase activity
AYR70_RS11765	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AYR70_RS11775	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYR70_RS11780	COG0517	IMP dehydrogenase activity
AYR70_RS11780	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYR70_RS11820	COG2814	Major facilitator Superfamily
AYR70_RS11850	COG1278	Cold shock
AYR70_RS11855	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS11890	COG1570	exodeoxyribonuclease VII activity
AYR70_RS11940	COG0583	DNA-binding transcription factor activity
AYR70_RS11945	COG4638	Rieske (2fe-2S)
AYR70_RS11950	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR70_RS11955	COG0633	Ferredoxin
AYR70_RS11955	COG0543	2 iron, 2 sulfur cluster binding
AYR70_RS11960	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS11965	COG3135	benzoate transporter
AYR70_RS11970	COG2814	Major facilitator Superfamily
AYR70_RS11985	COG1643	Atp-dependent helicase
AYR70_RS11990	COG0450	alkyl hydroperoxide reductase
AYR70_RS12000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYR70_RS12010	COG3634	alkyl hydroperoxide reductase activity
AYR70_RS12030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYR70_RS12035	COG0625	glutathione transferase activity
AYR70_RS12045	COG2885	chlorophyll binding
AYR70_RS12080	COG0542	response to heat
AYR70_RS12095	COG1765	OsmC-like protein
AYR70_RS12115	COG0667	Aldo Keto reductase
AYR70_RS12130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYR70_RS12140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYR70_RS12150	COG0527	aspartate kinase activity
AYR70_RS12160	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYR70_RS12170	COG3038	cytochrome b561
AYR70_RS12175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYR70_RS12180	COG2252	PERMEase
AYR70_RS12190	COG2072	flavoprotein involved in K transport
AYR70_RS12205	COG1741	Belongs to the pirin family
AYR70_RS12210	COG1309	transcriptional regulator
AYR70_RS12220	COG0300	oxidoreductase activity
AYR70_RS12225	COG2072	flavoprotein involved in K transport
AYR70_RS12325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AYR70_RS12355	COG1113	amino acid transport
AYR70_RS12375	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS12395	COG0531	amino acid
AYR70_RS12405	COG1113	amino acid transport
AYR70_RS12450	COG3209	COG3209 Rhs family protein
AYR70_RS12475	COG4269	membrane
AYR70_RS12490	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR70_RS12490	COG1902	pentaerythritol trinitrate reductase activity
AYR70_RS12500	COG3706	GGDEF domain
AYR70_RS12500	COG2203	Gaf domain
AYR70_RS12500	COG4251	negative regulation of phosphorylation
AYR70_RS12500	COG5001	Diguanylate cyclase
AYR70_RS12510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR70_RS12530	COG4172	Belongs to the ABC transporter superfamily
AYR70_RS12535	COG4239	(ABC) transporter, permease
AYR70_RS12540	COG4174	ABC transporter (Permease)
AYR70_RS12550	COG0741	lytic transglycosylase activity
AYR70_RS12550	COG1388	LysM domain
AYR70_RS12550	COG1388	LysM domain
AYR70_RS12550	COG0741	lytic transglycosylase activity
AYR70_RS12555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR70_RS12595	COG0583	DNA-binding transcription factor activity
AYR70_RS12600	COG1279	arginine transmembrane transporter activity
AYR70_RS12620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR70_RS12625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR70_RS12630	COG0006	proline dipeptidase activity
AYR70_RS12665	COG2194	sulfuric ester hydrolase activity
AYR70_RS12710	COG0739	heme binding
AYR70_RS13025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYR70_RS13050	COG3384	dioxygenase
AYR70_RS13060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR70_RS13065	COG2878	Part of a membrane complex involved in electron transport
AYR70_RS13070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYR70_RS13090	COG0768	penicillin binding
AYR70_RS13095	COG0742	ribosomal rna small subunit methyltransferase
AYR70_RS13110	COG0830	nickel cation binding
AYR70_RS13160	COG1253	flavin adenine dinucleotide binding
AYR70_RS13170	COG2851	Citrate transporter
AYR70_RS13215	COG1773	rubredoxin
AYR70_RS13220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR70_RS13230	COG0583	DNA-binding transcription factor activity
AYR70_RS13255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AYR70_RS13260	COG4181	ATPase activity
AYR70_RS13305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYR70_RS13325	COG0306	phosphate transporter
AYR70_RS13335	COG3958	Transketolase
AYR70_RS13340	COG3959	Transketolase, thiamine diphosphate binding domain
AYR70_RS13345	COG2271	Major facilitator Superfamily
AYR70_RS13350	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS13355	COG0583	DNA-binding transcription factor activity
AYR70_RS13370	COG2223	nitrite transmembrane transporter activity
AYR70_RS13375	COG2207	Transcriptional regulator
AYR70_RS13380	COG2066	Belongs to the glutaminase family
AYR70_RS13385	COG0242	peptide deformylase activity
AYR70_RS13390	COG0477	Major facilitator Superfamily
AYR70_RS13400	COG0028	Belongs to the TPP enzyme family
AYR70_RS13415	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS13420	COG2267	carboxylic ester hydrolase activity
AYR70_RS13430	COG2271	Major facilitator Superfamily
AYR70_RS13435	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR70_RS13445	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS13465	COG1414	Transcriptional regulator
AYR70_RS13480	COG1024	Enoyl-CoA hydratase
AYR70_RS13490	COG1215	transferase activity, transferring glycosyl groups
AYR70_RS13495	COG1649	PFAM Uncharacterised BCR, COG1649
AYR70_RS13495	COG0726	polysaccharide deacetylase
AYR70_RS13505	COG4681	YaeQ
AYR70_RS13515	COG0523	cobalamin synthesis protein
AYR70_RS13525	COG1607	acyl-coa hydrolase
AYR70_RS13535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR70_RS13540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR70_RS13545	COG1309	transcriptional regulator
AYR70_RS13570	COG2040	homocysteine
AYR70_RS13575	COG0531	amino acid
AYR70_RS13600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR70_RS13605	COG0477	Major facilitator Superfamily
AYR70_RS13670	COG1061	Type III restriction enzyme res subunit
AYR70_RS13680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR70_RS13685	COG1192	Involved in chromosome partitioning
AYR70_RS13695	COG1061	Type III restriction enzyme res subunit
AYR70_RS13720	COG1061	Type III restriction enzyme res subunit
AYR70_RS13730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR70_RS13735	COG1192	Involved in chromosome partitioning
AYR70_RS13745	COG1061	Type III restriction enzyme res subunit
AYR70_RS13835	COG0592	DNA-directed DNA polymerase activity
AYR70_RS13875	COG2026	Addiction module toxin, RelE StbE family
AYR70_RS14095	COG1484	DNA-dependent DNA replication
AYR70_RS14205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR70_RS14230	COG0405	Gamma-glutamyltransferase
AYR70_RS14235	COG2814	Major facilitator Superfamily
AYR70_RS14245	COG2050	protein possibly involved in aromatic compounds catabolism
AYR70_RS14260	COG1090	epimerase
AYR70_RS14280	COG0420	3'-5' exonuclease activity
AYR70_RS14305	COG0735	belongs to the Fur family
AYR70_RS14310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AYR70_RS14335	COG0121	glutamine amidotransferase
AYR70_RS14350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR70_RS14360	COG0210	DNA helicase
AYR70_RS14365	COG2885	chlorophyll binding
AYR70_RS14370	COG0204	Acyl-transferase
AYR70_RS14385	COG2894	cell division
AYR70_RS14410	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS14415	COG1674	ftsk spoiiie
AYR70_RS14415	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYR70_RS14420	COG0492	ferredoxin-NADP+ reductase activity
AYR70_RS14425	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYR70_RS14435	COG0456	acetyltransferase
AYR70_RS14480	COG1981	membrane
AYR70_RS14495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYR70_RS14495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR70_RS14515	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS14525	COG0657	acetylesterase activity
AYR70_RS14535	COG0473	3-isopropylmalate dehydrogenase activity
AYR70_RS14540	COG0583	DNA-binding transcription factor activity
AYR70_RS14560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR70_RS14585	COG0564	pseudouridine synthase activity
AYR70_RS14595	COG0358	DNA primase activity
AYR70_RS14610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AYR70_RS14640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR70_RS14670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYR70_RS14680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR70_RS14680	COG0352	thiamine-phosphate diphosphorylase activity
AYR70_RS14680	COG0351	phosphomethylpyrimidine kinase
AYR70_RS14685	COG1652	LysM domain
AYR70_RS14710	COG1399	metal-binding, possibly nucleic acid-binding protein
AYR70_RS14715	COG3101	peptidyl-lysine hydroxylation
AYR70_RS14720	COG0009	L-threonylcarbamoyladenylate synthase
AYR70_RS14725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYR70_RS14730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYR70_RS14745	COG4106	trans-aconitate 2-methyltransferase activity
AYR70_RS14760	COG0596	Alpha beta hydrolase
AYR70_RS14760	COG2226	methyltransferase
AYR70_RS14760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR70_RS14765	COG1877	trehalose-phosphatase activity
AYR70_RS14770	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AYR70_RS14775	COG2223	nitrite transmembrane transporter activity
AYR70_RS14795	COG1196	nuclear chromosome segregation
AYR70_RS14805	COG0730	response to heat
AYR70_RS14820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYR70_RS14830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR70_RS14880	COG0489	protein tyrosine kinase activity
AYR70_RS14890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR70_RS14890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR70_RS14920	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYR70_RS14925	COG2081	HI0933 family
AYR70_RS14935	COG0668	transmembrane transport
AYR70_RS14955	COG0583	DNA-binding transcription factor activity
AYR70_RS14975	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYR70_RS14980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR70_RS15010	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYR70_RS15050	COG0745	RESPONSE REGULATOR receiver
AYR70_RS15070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYR70_RS15080	COG2205	protein histidine kinase activity
AYR70_RS15150	COG4993	Dehydrogenase
AYR70_RS15170	COG0384	phenazine biosynthesis protein PhzF
AYR70_RS15195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR70_RS15210	COG0583	DNA-binding transcription factor activity
AYR70_RS15240	COG0583	DNA-binding transcription factor activity
AYR70_RS15255	COG0583	DNA-binding transcription factor activity
AYR70_RS15260	COG1053	succinate dehydrogenase
AYR70_RS15270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYR70_RS15275	COG2814	Major facilitator Superfamily
AYR70_RS15280	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS15285	COG0583	DNA-binding transcription factor activity
AYR70_RS15290	COG1063	alcohol dehydrogenase
AYR70_RS15320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYR70_RS15325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYR70_RS15330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR70_RS15345	COG3667	copper resistance
AYR70_RS15350	COG2132	Multicopper oxidase
AYR70_RS15360	COG0561	phosphatase activity
AYR70_RS15365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYR70_RS15390	COG1214	PFAM Peptidase M22, glycoprotease
AYR70_RS15445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYR70_RS15455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYR70_RS15460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYR70_RS15465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYR70_RS15525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR70_RS15535	COG1846	Transcriptional regulator
AYR70_RS15540	COG1764	response to oxidative stress
AYR70_RS15580	COG0037	tRNA processing
AYR70_RS15590	COG0248	Ppx GppA phosphatase
AYR70_RS15615	COG0072	phenylalanine-tRNA ligase activity
AYR70_RS15655	COG1238	metal cluster binding
AYR70_RS15660	COG0625	glutathione transferase activity
AYR70_RS15675	COG0318	PFAM AMP-dependent synthetase and ligase
AYR70_RS15680	COG3028	Belongs to the UPF0307 family
AYR70_RS15685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR70_RS15705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYR70_RS15710	COG0617	tRNA 3'-terminal CCA addition
AYR70_RS15715	COG1555	photosystem II stabilization
AYR70_RS15720	COG3956	TIGRFAM MazG family protein
AYR70_RS15730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR70_RS15750	COG2205	protein histidine kinase activity
AYR70_RS15750	COG5002	protein histidine kinase activity
AYR70_RS15750	COG0784	Response regulator, receiver
AYR70_RS15755	COG1024	Enoyl-CoA hydratase
AYR70_RS15760	COG2084	Dehydrogenase
AYR70_RS15765	COG3622	Belongs to the hyi family
AYR70_RS15795	COG0697	spore germination
AYR70_RS15805	COG2814	Major facilitator Superfamily
AYR70_RS15810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR70_RS15820	COG0583	DNA-binding transcription factor activity
AYR70_RS15825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYR70_RS15840	COG0084	hydrolase, TatD family'
AYR70_RS15855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYR70_RS15885	COG0440	acetolactate synthase activity
AYR70_RS15890	COG0028	Belongs to the TPP enzyme family
AYR70_RS15915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR70_RS15920	COG0577	efflux transmembrane transporter activity
AYR70_RS15920	COG1136	(ABC) transporter
AYR70_RS15925	COG1538	Outer membrane efflux protein
AYR70_RS15940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYR70_RS15945	COG1162	GTPase activity
AYR70_RS15955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AYR70_RS15975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYR70_RS15980	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS16020	COG2986	histidine ammonia-lyase
AYR70_RS16035	COG0318	PFAM AMP-dependent synthetase and ligase
AYR70_RS16045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR70_RS16090	COG1426	Protein conserved in bacteria
AYR70_RS16125	COG0793	Belongs to the peptidase S41A family
AYR70_RS16140	COG2267	carboxylic ester hydrolase activity
AYR70_RS16150	COG1012	belongs to the aldehyde dehydrogenase family
AYR70_RS16155	COG3265	gluconokinase activity
AYR70_RS16165	COG0800	Aldolase
AYR70_RS16175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR70_RS16180	COG0857	belongs to the CobB CobQ family
AYR70_RS16180	COG0280	phosphate acetyltransferase
AYR70_RS16185	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR70_RS16185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR70_RS16205	COG0740	serine-type endopeptidase activity
AYR70_RS16215	COG4774	siderophore transport
AYR70_RS16225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYR70_RS16235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR70_RS16235	COG2813	Specifically methylates the guanine in position
AYR70_RS16335	COG0788	formyltetrahydrofolate deformylase activity
AYR70_RS16360	COG4651	solute:proton antiporter activity
AYR70_RS16360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR70_RS16380	COG0724	RNA recognition motif
AYR70_RS16385	COG0210	DNA helicase
AYR70_RS16410	COG1733	regulation of RNA biosynthetic process
AYR70_RS16420	COG2900	Belongs to the SlyX family
AYR70_RS16425	COG0488	(ABC) transporter
AYR70_RS16430	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS16435	COG1560	Kdo2-lipid A biosynthetic process
AYR70_RS16445	COG1301	dicarboxylic acid transport
AYR70_RS16500	COG0473	3-isopropylmalate dehydrogenase activity
AYR70_RS16565	COG0583	DNA-binding transcription factor activity
AYR70_RS16575	COG0625	glutathione transferase activity
AYR70_RS16580	COG2378	regulation of single-species biofilm formation
AYR70_RS16585	COG0546	phosphoglycolate phosphatase activity
AYR70_RS16595	COG1530	ribonuclease E activity
AYR70_RS16600	COG0318	PFAM AMP-dependent synthetase and ligase
AYR70_RS16615	COG0583	DNA-binding transcription factor activity
AYR70_RS16620	COG4221	oxidoreductase activity
AYR70_RS16625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYR70_RS16635	COG0534	Mate efflux family protein
AYR70_RS16650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYR70_RS16685	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AYR70_RS16690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR70_RS16705	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR70_RS16715	COG0644	oxidoreductase
AYR70_RS16715	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AYR70_RS16720	COG0425	Belongs to the sulfur carrier protein TusA family
AYR70_RS16725	COG4535	Mg2 and Co2 transporter CorC
AYR70_RS16735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR70_RS16755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYR70_RS16760	COG0475	glutathione-regulated potassium exporter activity
AYR70_RS16760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR70_RS16765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYR70_RS16775	COG0484	heat shock protein binding
AYR70_RS16780	COG0789	Transcriptional regulator
AYR70_RS16785	COG0598	Magnesium transport protein CorA
AYR70_RS16800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR70_RS16805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR70_RS16810	COG1074	ATP-dependent DNA helicase activity
AYR70_RS16815	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AYR70_RS16835	COG2226	methyltransferase
AYR70_RS16850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR70_RS16855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYR70_RS16870	COG2111	Na H antiporter
AYR70_RS16870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR70_RS16875	COG1006	Multisubunit Na H antiporter MnhC subunit
AYR70_RS16880	COG0651	ATP synthesis coupled electron transport
AYR70_RS16885	COG1863	multisubunit Na H antiporter MnhE subunit
AYR70_RS16890	COG2212	antiporter activity
AYR70_RS16895	COG1320	monovalent cation:proton antiporter activity
AYR70_RS16910	COG0195	Participates in both transcription termination and antitermination
AYR70_RS16960	COG0237	dephospho-CoA kinase activity
AYR70_RS16970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR70_RS16985	COG0497	DNA recombination
AYR70_RS16995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYR70_RS17025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR70_RS17025	COG2169	Transcriptional regulator
AYR70_RS17030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYR70_RS17095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYR70_RS17110	COG0326	Molecular chaperone. Has ATPase activity
AYR70_RS17125	COG2056	Na+-H+ antiporter family
AYR70_RS17130	COG0596	Alpha beta hydrolase
AYR70_RS17225	COG0546	phosphoglycolate phosphatase activity
AYR70_RS17230	COG1716	ATPase activity
AYR70_RS17275	COG0181	hydroxymethylbilane synthase activity
AYR70_RS17285	COG3275	phosphorelay sensor kinase activity
AYR70_RS17305	COG1538	Outer membrane efflux protein
AYR70_RS17310	COG0697	spore germination
AYR70_RS17335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR70_RS17340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AYR70_RS17345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR70_RS17350	COG0772	Belongs to the SEDS family
AYR70_RS17375	COG4974	Belongs to the 'phage' integrase family
AYR70_RS17380	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR70_RS17390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYR70_RS17400	COG2197	response regulator
AYR70_RS17415	COG0793	Belongs to the peptidase S41A family
AYR70_RS17420	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYR70_RS17425	COG0795	lipopolysaccharide-transporting ATPase activity
AYR70_RS17465	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR70_RS17465	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR70_RS17475	COG0004	ammonium transporteR
AYR70_RS17480	COG0347	Belongs to the P(II) protein family
AYR70_RS17490	COG0606	chelatase, subunit chli
AYR70_RS17495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR70_RS17500	COG0235	Class ii aldolase
AYR70_RS17505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR70_RS17520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYR70_RS17535	COG0318	PFAM AMP-dependent synthetase and ligase
AYR70_RS17545	COG0477	Major facilitator Superfamily
AYR70_RS17550	COG2860	membrane
AYR70_RS17555	COG3012	SEC-C Motif Domain Protein
AYR70_RS17560	COG1253	flavin adenine dinucleotide binding
AYR70_RS17570	COG2814	Major facilitator Superfamily
AYR70_RS17580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYR70_RS17615	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYR70_RS17625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AYR70_RS17660	COG1309	transcriptional regulator
AYR70_RS17695	COG0758	DNA mediated transformation
AYR70_RS17705	COG0697	spore germination
AYR70_RS17710	COG1309	transcriptional regulator
AYR70_RS17725	COG0386	Belongs to the glutathione peroxidase family
AYR70_RS17795	COG1121	(ABC) transporter
AYR70_RS17800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYR70_RS17805	COG1280	lysine exporter protein (LysE YggA)
AYR70_RS17810	COG2837	iron assimilation
AYR70_RS17820	COG0281	malic enzyme
AYR70_RS17865	COG0519	Catalyzes the synthesis of GMP from XMP
AYR70_RS17865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR70_RS17870	COG4399	Belongs to the UPF0754 family
AYR70_RS17880	COG0586	Pfam SNARE associated Golgi protein
AYR70_RS17895	COG1192	Involved in chromosome partitioning
AYR70_RS17905	COG0271	Belongs to the BolA IbaG family
AYR70_RS17920	COG0477	Major facilitator Superfamily
AYR70_RS17925	COG1024	Enoyl-CoA hydratase
AYR70_RS17930	COG1024	Enoyl-CoA hydratase
AYR70_RS17935	COG1960	acyl-CoA dehydrogenase activity
AYR70_RS17940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR70_RS17960	COG1113	amino acid transport
AYR70_RS17965	COG1113	amino acid transport
AYR70_RS17970	COG0251	oxidation-reduction process
AYR70_RS18010	COG0564	pseudouridine synthase activity
AYR70_RS18075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYR70_RS18090	COG1802	Transcriptional regulator
AYR70_RS18095	COG1448	Aminotransferase
AYR70_RS18100	COG0277	FAD linked oxidase domain protein
AYR70_RS18110	COG2186	Transcriptional regulator
AYR70_RS18120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR70_RS18130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR70_RS18145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYR70_RS18150	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYR70_RS18155	COG1216	Glycosyl transferase, family 2
AYR70_RS18165	COG3562	capsule polysaccharide
AYR70_RS18175	COG2089	acid synthase
AYR70_RS18190	COG1083	cytidylyl-transferase
AYR70_RS18195	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYR70_RS18200	COG1086	Polysaccharide biosynthesis protein
AYR70_RS18205	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYR70_RS18235	COG0728	peptidoglycan biosynthetic process
AYR70_RS18240	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYR70_RS18295	COG0546	phosphoglycolate phosphatase activity
AYR70_RS18300	COG1028	Short-chain dehydrogenase reductase Sdr
AYR70_RS18320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR70_RS18325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR70_RS18330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR70_RS18335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR70_RS18340	COG1116	anion transmembrane transporter activity
AYR70_RS18345	COG1309	transcriptional regulator
AYR70_RS18350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYR70_RS18360	COG0196	riboflavin kinase activity
AYR70_RS18365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYR70_RS18375	COG1047	Peptidyl-prolyl cis-trans
AYR70_RS18415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYR70_RS18420	COG0657	acetylesterase activity
AYR70_RS18440	COG0583	DNA-binding transcription factor activity
AYR70_RS18470	COG2951	lytic endotransglycosylase activity
AYR70_RS18475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYR70_RS18490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYR70_RS18500	COG0671	phosphoesterase, PA-phosphatase related
AYR70_RS18505	COG0861	Integral membrane protein TerC family
AYR70_RS18515	COG0754	glutathionylspermidine amidase activity
AYR70_RS18525	COG0402	S-adenosylhomocysteine deaminase activity
AYR70_RS18545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR70_RS18550	COG1230	cation diffusion facilitator family transporter
AYR70_RS18565	COG0706	membrane insertase activity