locus-tag	class	description
AYR68_RS00010	COG0592	DNA-directed DNA polymerase activity
AYR68_RS00020	COG0187	DNA topoisomerase II activity
AYR68_RS00030	COG0586	Pfam SNARE associated Golgi protein
AYR68_RS00035	COG0488	(ABC) transporter
AYR68_RS00060	COG0596	Alpha beta hydrolase
AYR68_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AYR68_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYR68_RS00110	COG0733	neurotransmitter:sodium symporter activity
AYR68_RS00150	COG2233	PERMEase
AYR68_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS00200	COG2814	Major facilitator Superfamily
AYR68_RS00205	COG0656	L-ascorbic acid biosynthetic process
AYR68_RS00210	COG0583	DNA-binding transcription factor activity
AYR68_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR68_RS00225	COG1064	alcohol dehydrogenase
AYR68_RS00230	COG2818	Glycosylase
AYR68_RS00245	COG1194	a g-specific adenine glycosylase
AYR68_RS00275	COG2983	Belongs to the UPF0260 family
AYR68_RS00280	COG2133	pyrroloquinoline quinone binding
AYR68_RS00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR68_RS00290	COG2116	formate transmembrane transporter activity
AYR68_RS00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR68_RS00315	COG1335	isochorismatase
AYR68_RS00320	COG0385	Bile acid
AYR68_RS00325	COG0534	Mate efflux family protein
AYR68_RS00330	COG1683	Conserved Protein
AYR68_RS00350	COG0625	glutathione transferase activity
AYR68_RS00360	COG1113	amino acid transport
AYR68_RS00370	COG0523	cobalamin synthesis protein
AYR68_RS00380	COG2188	Transcriptional regulator
AYR68_RS00410	COG0010	Belongs to the arginase family
AYR68_RS00445	COG0589	response to stress
AYR68_RS00450	COG0659	secondary active sulfate transmembrane transporter activity
AYR68_RS00500	COG0606	chelatase, subunit chli
AYR68_RS00510	COG0347	Belongs to the P(II) protein family
AYR68_RS00515	COG0004	ammonium transporteR
AYR68_RS00525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR68_RS00525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR68_RS00565	COG0795	lipopolysaccharide-transporting ATPase activity
AYR68_RS00570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYR68_RS00575	COG0793	Belongs to the peptidase S41A family
AYR68_RS00590	COG2197	response regulator
AYR68_RS00600	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYR68_RS00610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR68_RS00615	COG4974	Belongs to the 'phage' integrase family
AYR68_RS00640	COG0772	Belongs to the SEDS family
AYR68_RS00645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR68_RS00650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AYR68_RS00655	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR68_RS00680	COG0697	spore germination
AYR68_RS00685	COG1538	Outer membrane efflux protein
AYR68_RS00705	COG3275	phosphorelay sensor kinase activity
AYR68_RS00715	COG0181	hydroxymethylbilane synthase activity
AYR68_RS00760	COG1716	ATPase activity
AYR68_RS00765	COG0546	phosphoglycolate phosphatase activity
AYR68_RS00860	COG0596	Alpha beta hydrolase
AYR68_RS00865	COG2056	Na+-H+ antiporter family
AYR68_RS00880	COG0326	Molecular chaperone. Has ATPase activity
AYR68_RS00895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYR68_RS00960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYR68_RS00965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR68_RS00965	COG2169	Transcriptional regulator
AYR68_RS00995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYR68_RS01005	COG0497	DNA recombination
AYR68_RS01020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR68_RS01030	COG0237	dephospho-CoA kinase activity
AYR68_RS01080	COG0195	Participates in both transcription termination and antitermination
AYR68_RS01095	COG1320	monovalent cation:proton antiporter activity
AYR68_RS01100	COG2212	antiporter activity
AYR68_RS01105	COG1863	multisubunit Na H antiporter MnhE subunit
AYR68_RS01110	COG0651	ATP synthesis coupled electron transport
AYR68_RS01115	COG1006	Multisubunit Na H antiporter MnhC subunit
AYR68_RS01120	COG2111	Na H antiporter
AYR68_RS01120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR68_RS01135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYR68_RS01140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR68_RS01155	COG2226	methyltransferase
AYR68_RS01175	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AYR68_RS01180	COG1074	ATP-dependent DNA helicase activity
AYR68_RS01185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR68_RS01190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR68_RS01205	COG0598	Magnesium transport protein CorA
AYR68_RS01210	COG0789	Transcriptional regulator
AYR68_RS01215	COG0484	heat shock protein binding
AYR68_RS01225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYR68_RS01230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR68_RS01230	COG0475	glutathione-regulated potassium exporter activity
AYR68_RS01235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYR68_RS01255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR68_RS01265	COG4535	Mg2 and Co2 transporter CorC
AYR68_RS01270	COG0425	Belongs to the sulfur carrier protein TusA family
AYR68_RS01275	COG0644	oxidoreductase
AYR68_RS01275	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AYR68_RS01285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR68_RS01300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR68_RS01305	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AYR68_RS01345	COG4372	Transposase
AYR68_RS01355	COG2132	Multicopper oxidase
AYR68_RS01370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYR68_RS01385	COG0534	Mate efflux family protein
AYR68_RS01395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYR68_RS01400	COG4221	oxidoreductase activity
AYR68_RS01405	COG0583	DNA-binding transcription factor activity
AYR68_RS01420	COG0318	PFAM AMP-dependent synthetase and ligase
AYR68_RS01425	COG1530	ribonuclease E activity
AYR68_RS01435	COG0546	phosphoglycolate phosphatase activity
AYR68_RS01440	COG2378	regulation of single-species biofilm formation
AYR68_RS01445	COG0625	glutathione transferase activity
AYR68_RS01455	COG0583	DNA-binding transcription factor activity
AYR68_RS01520	COG0473	3-isopropylmalate dehydrogenase activity
AYR68_RS01575	COG1301	dicarboxylic acid transport
AYR68_RS01585	COG1560	Kdo2-lipid A biosynthetic process
AYR68_RS01590	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS01595	COG0488	(ABC) transporter
AYR68_RS01600	COG2900	Belongs to the SlyX family
AYR68_RS01610	COG1733	regulation of RNA biosynthetic process
AYR68_RS01635	COG0210	DNA helicase
AYR68_RS01640	COG0724	RNA recognition motif
AYR68_RS01660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR68_RS01660	COG4651	solute:proton antiporter activity
AYR68_RS01685	COG0788	formyltetrahydrofolate deformylase activity
AYR68_RS01785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR68_RS01785	COG2813	Specifically methylates the guanine in position
AYR68_RS01795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYR68_RS01805	COG4774	siderophore transport
AYR68_RS01815	COG0740	serine-type endopeptidase activity
AYR68_RS01835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR68_RS01835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR68_RS01840	COG0857	belongs to the CobB CobQ family
AYR68_RS01840	COG0280	phosphate acetyltransferase
AYR68_RS01845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR68_RS01855	COG0800	Aldolase
AYR68_RS01865	COG3265	gluconokinase activity
AYR68_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS01880	COG2267	carboxylic ester hydrolase activity
AYR68_RS01895	COG0793	Belongs to the peptidase S41A family
AYR68_RS01930	COG1426	Protein conserved in bacteria
AYR68_RS01975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR68_RS01985	COG0318	PFAM AMP-dependent synthetase and ligase
AYR68_RS02000	COG2986	histidine ammonia-lyase
AYR68_RS02040	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS02045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYR68_RS02065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AYR68_RS02075	COG1162	GTPase activity
AYR68_RS02080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYR68_RS02095	COG1538	Outer membrane efflux protein
AYR68_RS02100	COG0577	efflux transmembrane transporter activity
AYR68_RS02100	COG1136	(ABC) transporter
AYR68_RS02105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS02130	COG0028	Belongs to the TPP enzyme family
AYR68_RS02135	COG0440	acetolactate synthase activity
AYR68_RS02165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYR68_RS02180	COG0084	hydrolase, TatD family'
AYR68_RS02195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYR68_RS02200	COG0583	DNA-binding transcription factor activity
AYR68_RS02210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR68_RS02215	COG2814	Major facilitator Superfamily
AYR68_RS02225	COG0697	spore germination
AYR68_RS02255	COG3622	Belongs to the hyi family
AYR68_RS02260	COG2084	Dehydrogenase
AYR68_RS02265	COG1024	Enoyl-CoA hydratase
AYR68_RS02270	COG5002	protein histidine kinase activity
AYR68_RS02270	COG2205	protein histidine kinase activity
AYR68_RS02270	COG0784	Response regulator, receiver
AYR68_RS02290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR68_RS02300	COG3956	TIGRFAM MazG family protein
AYR68_RS02305	COG1555	photosystem II stabilization
AYR68_RS02310	COG0617	tRNA 3'-terminal CCA addition
AYR68_RS02315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYR68_RS02335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR68_RS02340	COG3028	Belongs to the UPF0307 family
AYR68_RS02345	COG0318	PFAM AMP-dependent synthetase and ligase
AYR68_RS02360	COG0625	glutathione transferase activity
AYR68_RS02365	COG1238	metal cluster binding
AYR68_RS02405	COG0072	phenylalanine-tRNA ligase activity
AYR68_RS02430	COG0248	Ppx GppA phosphatase
AYR68_RS02440	COG0037	tRNA processing
AYR68_RS02495	COG1764	response to oxidative stress
AYR68_RS02500	COG1846	Transcriptional regulator
AYR68_RS02510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR68_RS02570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYR68_RS02575	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYR68_RS02580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYR68_RS02590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYR68_RS02645	COG1214	PFAM Peptidase M22, glycoprotease
AYR68_RS02670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYR68_RS02675	COG0561	phosphatase activity
AYR68_RS02685	COG2132	Multicopper oxidase
AYR68_RS02690	COG3667	copper resistance
AYR68_RS02705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR68_RS02710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYR68_RS02715	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYR68_RS02745	COG1063	alcohol dehydrogenase
AYR68_RS02750	COG0583	DNA-binding transcription factor activity
AYR68_RS02755	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS02760	COG2814	Major facilitator Superfamily
AYR68_RS02765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYR68_RS02775	COG1053	succinate dehydrogenase
AYR68_RS02780	COG0583	DNA-binding transcription factor activity
AYR68_RS02795	COG0583	DNA-binding transcription factor activity
AYR68_RS02825	COG0583	DNA-binding transcription factor activity
AYR68_RS02840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR68_RS02870	COG0384	phenazine biosynthesis protein PhzF
AYR68_RS02890	COG4993	Dehydrogenase
AYR68_RS02960	COG2205	protein histidine kinase activity
AYR68_RS02970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYR68_RS02990	COG0745	RESPONSE REGULATOR receiver
AYR68_RS03030	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYR68_RS03060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR68_RS03065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYR68_RS03085	COG0583	DNA-binding transcription factor activity
AYR68_RS03105	COG0668	transmembrane transport
AYR68_RS03115	COG2081	HI0933 family
AYR68_RS03120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYR68_RS03150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR68_RS03150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR68_RS03160	COG0489	protein tyrosine kinase activity
AYR68_RS03210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR68_RS03220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYR68_RS03235	COG0730	response to heat
AYR68_RS03245	COG1196	nuclear chromosome segregation
AYR68_RS03265	COG2223	nitrite transmembrane transporter activity
AYR68_RS03270	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AYR68_RS03275	COG1877	trehalose-phosphatase activity
AYR68_RS03280	COG2226	methyltransferase
AYR68_RS03280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR68_RS03280	COG0596	Alpha beta hydrolase
AYR68_RS03295	COG4106	trans-aconitate 2-methyltransferase activity
AYR68_RS03310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYR68_RS03315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYR68_RS03320	COG0009	L-threonylcarbamoyladenylate synthase
AYR68_RS03325	COG3101	peptidyl-lysine hydroxylation
AYR68_RS03330	COG1399	metal-binding, possibly nucleic acid-binding protein
AYR68_RS03355	COG1652	LysM domain
AYR68_RS03360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR68_RS03360	COG0352	thiamine-phosphate diphosphorylase activity
AYR68_RS03360	COG0351	phosphomethylpyrimidine kinase
AYR68_RS03370	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYR68_RS03400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR68_RS03430	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AYR68_RS03445	COG0358	DNA primase activity
AYR68_RS03455	COG0564	pseudouridine synthase activity
AYR68_RS03480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR68_RS03500	COG0583	DNA-binding transcription factor activity
AYR68_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
AYR68_RS03515	COG0657	acetylesterase activity
AYR68_RS03525	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS03545	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYR68_RS03545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR68_RS03560	COG1981	membrane
AYR68_RS03605	COG0456	acetyltransferase
AYR68_RS03615	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYR68_RS03620	COG0492	ferredoxin-NADP+ reductase activity
AYR68_RS03625	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYR68_RS03625	COG1674	ftsk spoiiie
AYR68_RS03630	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS03650	COG4372	Transposase
AYR68_RS03655	COG4372	Transposase
AYR68_RS03680	COG2894	cell division
AYR68_RS03695	COG0204	Acyl-transferase
AYR68_RS03700	COG2885	chlorophyll binding
AYR68_RS03705	COG0210	DNA helicase
AYR68_RS03715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR68_RS03730	COG0121	glutamine amidotransferase
AYR68_RS03750	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AYR68_RS03755	COG0735	belongs to the Fur family
AYR68_RS03780	COG0420	3'-5' exonuclease activity
AYR68_RS03800	COG1090	epimerase
AYR68_RS03815	COG2050	protein possibly involved in aromatic compounds catabolism
AYR68_RS03825	COG2814	Major facilitator Superfamily
AYR68_RS03830	COG0405	Gamma-glutamyltransferase
AYR68_RS03895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR68_RS03985	COG1484	DNA-dependent DNA replication
AYR68_RS04030	COG3755	Protein conserved in bacteria
AYR68_RS04175	COG2026	Addiction module toxin, RelE StbE family
AYR68_RS04215	COG0592	DNA-directed DNA polymerase activity
AYR68_RS04345	COG0477	Major facilitator Superfamily
AYR68_RS04350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR68_RS04375	COG0531	amino acid
AYR68_RS04380	COG2040	homocysteine
AYR68_RS04405	COG1309	transcriptional regulator
AYR68_RS04410	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR68_RS04415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR68_RS04425	COG1607	acyl-coa hydrolase
AYR68_RS04435	COG0523	cobalamin synthesis protein
AYR68_RS04445	COG4681	YaeQ
AYR68_RS04455	COG1649	PFAM Uncharacterised BCR, COG1649
AYR68_RS04455	COG0726	polysaccharide deacetylase
AYR68_RS04460	COG1215	transferase activity, transferring glycosyl groups
AYR68_RS04470	COG1024	Enoyl-CoA hydratase
AYR68_RS04485	COG1414	Transcriptional regulator
AYR68_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS04515	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR68_RS04520	COG2271	Major facilitator Superfamily
AYR68_RS04530	COG2267	carboxylic ester hydrolase activity
AYR68_RS04535	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS04550	COG0028	Belongs to the TPP enzyme family
AYR68_RS04560	COG0477	Major facilitator Superfamily
AYR68_RS04565	COG0242	peptide deformylase activity
AYR68_RS04570	COG2066	Belongs to the glutaminase family
AYR68_RS04575	COG2207	Transcriptional regulator
AYR68_RS04580	COG2223	nitrite transmembrane transporter activity
AYR68_RS04595	COG0583	DNA-binding transcription factor activity
AYR68_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS04605	COG2271	Major facilitator Superfamily
AYR68_RS04610	COG3959	Transketolase, thiamine diphosphate binding domain
AYR68_RS04615	COG3958	Transketolase
AYR68_RS04625	COG0306	phosphate transporter
AYR68_RS04645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYR68_RS04690	COG4181	ATPase activity
AYR68_RS04695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AYR68_RS04720	COG0583	DNA-binding transcription factor activity
AYR68_RS04730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR68_RS04735	COG1773	rubredoxin
AYR68_RS04780	COG2851	Citrate transporter
AYR68_RS04790	COG1253	flavin adenine dinucleotide binding
AYR68_RS04830	COG0804	urea catabolic process
AYR68_RS04840	COG0830	nickel cation binding
AYR68_RS04855	COG0742	ribosomal rna small subunit methyltransferase
AYR68_RS04860	COG0768	penicillin binding
AYR68_RS04880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYR68_RS04885	COG2878	Part of a membrane complex involved in electron transport
AYR68_RS04890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR68_RS04900	COG3384	dioxygenase
AYR68_RS04935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYR68_RS05100	COG5410	chromosome segregation
AYR68_RS05170	COG1061	Type III restriction enzyme res subunit
AYR68_RS05180	COG1192	Involved in chromosome partitioning
AYR68_RS05185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR68_RS05195	COG1061	Type III restriction enzyme res subunit
AYR68_RS05330	COG2194	sulfuric ester hydrolase activity
AYR68_RS05365	COG0006	proline dipeptidase activity
AYR68_RS05370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR68_RS05375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR68_RS05395	COG1279	arginine transmembrane transporter activity
AYR68_RS05400	COG0583	DNA-binding transcription factor activity
AYR68_RS05450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR68_RS05455	COG1388	LysM domain
AYR68_RS05455	COG1388	LysM domain
AYR68_RS05455	COG0741	lytic transglycosylase activity
AYR68_RS05455	COG0741	lytic transglycosylase activity
AYR68_RS05465	COG4174	ABC transporter (Permease)
AYR68_RS05470	COG4239	(ABC) transporter, permease
AYR68_RS05475	COG4172	Belongs to the ABC transporter superfamily
AYR68_RS05495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR68_RS05505	COG4251	negative regulation of phosphorylation
AYR68_RS05505	COG3706	GGDEF domain
AYR68_RS05505	COG5001	Diguanylate cyclase
AYR68_RS05505	COG2203	Gaf domain
AYR68_RS05515	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR68_RS05515	COG1902	pentaerythritol trinitrate reductase activity
AYR68_RS05530	COG4269	membrane
AYR68_RS05555	COG3209	COG3209 Rhs family protein
AYR68_RS05560	COG4372	Transposase
AYR68_RS05615	COG1113	amino acid transport
AYR68_RS05625	COG0531	amino acid
AYR68_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS05665	COG1113	amino acid transport
AYR68_RS05700	COG2072	flavoprotein involved in K transport
AYR68_RS05710	COG2252	PERMEase
AYR68_RS05715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYR68_RS05720	COG3038	cytochrome b561
AYR68_RS05730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYR68_RS05740	COG0527	aspartate kinase activity
AYR68_RS05750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYR68_RS05760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYR68_RS05775	COG0667	Aldo Keto reductase
AYR68_RS05785	COG1765	OsmC-like protein
AYR68_RS05800	COG0542	response to heat
AYR68_RS05835	COG2885	chlorophyll binding
AYR68_RS05845	COG0625	glutathione transferase activity
AYR68_RS05850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYR68_RS05870	COG3634	alkyl hydroperoxide reductase activity
AYR68_RS05880	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYR68_RS05890	COG0450	alkyl hydroperoxide reductase
AYR68_RS05895	COG1643	Atp-dependent helicase
AYR68_RS05910	COG2814	Major facilitator Superfamily
AYR68_RS05915	COG3135	benzoate transporter
AYR68_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS05925	COG0543	2 iron, 2 sulfur cluster binding
AYR68_RS05925	COG0633	Ferredoxin
AYR68_RS05930	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR68_RS05935	COG4638	Rieske (2fe-2S)
AYR68_RS05940	COG0583	DNA-binding transcription factor activity
AYR68_RS05990	COG1570	exodeoxyribonuclease VII activity
AYR68_RS06035	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS06040	COG1278	Cold shock
AYR68_RS06070	COG2814	Major facilitator Superfamily
AYR68_RS06110	COG0517	IMP dehydrogenase activity
AYR68_RS06110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYR68_RS06115	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYR68_RS06125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AYR68_RS06130	COG1137	ATPase activity
AYR68_RS06135	COG1538	Outer membrane efflux protein
AYR68_RS06165	COG4122	O-methyltransferase activity
AYR68_RS06175	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AYR68_RS06190	COG1522	sequence-specific DNA binding
AYR68_RS06195	COG5006	permease, DMT superfamily
AYR68_RS06205	COG1560	Kdo2-lipid A biosynthetic process
AYR68_RS06215	COG2814	Major facilitator Superfamily
AYR68_RS06235	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR68_RS06280	COG0583	DNA-binding transcription factor activity
AYR68_RS06285	COG1914	H( )-stimulated, divalent metal cation uptake system
AYR68_RS06305	COG4770	biotin carboxylase activity
AYR68_RS06310	COG0038	chloride channel
AYR68_RS06335	COG1309	transcriptional regulator
AYR68_RS06345	COG1063	alcohol dehydrogenase
AYR68_RS06360	COG0439	Biotin carboxylase
AYR68_RS06365	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR68_RS06370	COG1733	regulation of RNA biosynthetic process
AYR68_RS06385	COG0864	Transcriptional regulator
AYR68_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR68_RS06400	COG1116	anion transmembrane transporter activity
AYR68_RS06515	COG0590	tRNA wobble adenosine to inosine editing
AYR68_RS06520	COG2807	transmembrane transport
AYR68_RS06535	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYR68_RS06555	COG0789	Transcriptional regulator
AYR68_RS06565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR68_RS06585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR68_RS06620	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS06625	COG0531	amino acid
AYR68_RS06630	COG1760	l-serine dehydratase
AYR68_RS06635	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS06635	COG2030	dehydratase
AYR68_RS06640	COG3396	Phenylacetate-CoA oxygenase
AYR68_RS06645	COG3460	Phenylacetate-CoA oxygenase
AYR68_RS06650	COG3396	Phenylacetate-CoA oxygenase
AYR68_RS06655	COG2151	metal-sulfur cluster biosynthetic enzyme
AYR68_RS06660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR68_RS06665	COG1024	Enoyl-CoA hydratase
AYR68_RS06670	COG1024	Enoyl-CoA hydratase
AYR68_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR68_RS06680	COG0183	Belongs to the thiolase family
AYR68_RS06685	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYR68_RS06690	COG3327	negative regulation of DNA-templated transcription, initiation
AYR68_RS06700	COG2050	protein possibly involved in aromatic compounds catabolism
AYR68_RS06735	COG0753	catalase activity
AYR68_RS06740	COG3038	cytochrome b561
AYR68_RS06770	COG2267	carboxylic ester hydrolase activity
AYR68_RS06775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR68_RS06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR68_RS06785	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS06790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR68_RS06800	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS06805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR68_RS06810	COG0583	DNA-binding transcription factor activity
AYR68_RS06820	COG1414	Transcriptional regulator
AYR68_RS06825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR68_RS06835	COG1840	ABC-type Fe3 transport system, periplasmic component
AYR68_RS06840	COG3842	ATPase activity
AYR68_RS06855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYR68_RS06860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR68_RS06865	COG2814	Major facilitator Superfamily
AYR68_RS06870	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS06885	COG1024	Enoyl-CoA hydratase
AYR68_RS06895	COG2814	Major facilitator Superfamily
AYR68_RS06905	COG0183	Belongs to the thiolase family
AYR68_RS06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR68_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS06920	COG1024	Enoyl-CoA hydratase
AYR68_RS06925	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS06930	COG2814	Major facilitator Superfamily
AYR68_RS06935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR68_RS06940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR68_RS06950	COG2814	Major facilitator Superfamily
AYR68_RS06960	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS06975	COG0583	DNA-binding transcription factor activity
AYR68_RS06985	COG4770	biotin carboxylase activity
AYR68_RS06990	COG1024	Enoyl-CoA hydratase
AYR68_RS06995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR68_RS07000	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS07005	COG1309	transcriptional regulator
AYR68_RS07010	COG0318	PFAM AMP-dependent synthetase and ligase
AYR68_RS07030	COG0583	DNA-binding transcription factor activity
AYR68_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS07100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR68_RS07120	COG0784	Response regulator, receiver
AYR68_RS07120	COG2205	protein histidine kinase activity
AYR68_RS07135	COG0765	amino acid transport
AYR68_RS07140	COG0765	amino acid transport
AYR68_RS07145	COG1126	abc transporter atp-binding protein
AYR68_RS07155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR68_RS07165	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS07170	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYR68_RS07175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR68_RS07180	COG1045	serine acetyltransferase
AYR68_RS07195	COG0583	DNA-binding transcription factor activity
AYR68_RS07200	COG0625	glutathione transferase activity
AYR68_RS07205	COG0625	glutathione transferase activity
AYR68_RS07210	COG0583	DNA-binding transcription factor activity
AYR68_RS07220	COG1346	cytolysis
AYR68_RS07240	COG2814	Major facilitator Superfamily
AYR68_RS07250	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AYR68_RS07255	COG3052	prosthetic group binding
AYR68_RS07275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AYR68_RS07295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR68_RS07305	COG1294	oxidase, subunit
AYR68_RS07310	COG1271	oxidase subunit
AYR68_RS07330	COG0477	Major facilitator Superfamily
AYR68_RS07375	COG1132	(ABC) transporter
AYR68_RS07435	COG0488	(ABC) transporter
AYR68_RS07440	COG3173	Aminoglycoside phosphotransferase
AYR68_RS07450	COG2433	Pfam Transposase IS66
AYR68_RS07480	COG2135	peptidase activity
AYR68_RS07495	COG3300	MHYT domain
AYR68_RS07495	COG5001	Diguanylate cyclase
AYR68_RS07515	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AYR68_RS07515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR68_RS07515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR68_RS07520	COG1105	Belongs to the carbohydrate kinase PfkB family
AYR68_RS07525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYR68_RS07525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR68_RS07555	COG0024	Methionine aminopeptidase
AYR68_RS07560	COG0583	DNA-binding transcription factor activity
AYR68_RS07570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AYR68_RS07575	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR68_RS07580	COG0516	GMP reductase activity
AYR68_RS07580	COG0517	IMP dehydrogenase activity
AYR68_RS07605	COG0552	protein localization to endoplasmic reticulum
AYR68_RS07615	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AYR68_RS07630	COG4890	Cyd operon protein YbgT
AYR68_RS07635	COG1294	oxidase, subunit
AYR68_RS07650	COG1585	Membrane protein implicated in regulation of membrane protease activity
AYR68_RS07660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYR68_RS07665	COG4774	siderophore transport
AYR68_RS07680	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYR68_RS07685	COG0569	domain protein
AYR68_RS07690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR68_RS07720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYR68_RS07725	COG0542	response to heat
AYR68_RS07750	COG1902	pentaerythritol trinitrate reductase activity
AYR68_RS07750	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR68_RS07795	COG2323	membrane
AYR68_RS07800	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AYR68_RS07810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR68_RS07815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR68_RS07820	COG0183	Belongs to the thiolase family
AYR68_RS07825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYR68_RS07830	COG0596	Alpha beta hydrolase
AYR68_RS07835	COG2271	Major facilitator Superfamily
AYR68_RS07840	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR68_RS07845	COG3485	protocatechuate 3,4-dioxygenase
AYR68_RS07850	COG3485	protocatechuate 3,4-dioxygenase
AYR68_RS07855	COG0710	3-dehydroquinate dehydratase activity
AYR68_RS07860	COG3420	alginic acid biosynthetic process
AYR68_RS07865	COG3659	wide pore channel activity
AYR68_RS07870	COG4993	Dehydrogenase
AYR68_RS07880	COG2391	methyltransferase activity
AYR68_RS07895	COG1414	Transcriptional regulator
AYR68_RS07900	COG0583	DNA-binding transcription factor activity
AYR68_RS07905	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS07930	COG2814	Major facilitator Superfamily
AYR68_RS07940	COG0154	amidase activity
AYR68_RS07960	COG4638	Rieske (2fe-2S)
AYR68_RS07970	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS07980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR68_RS07990	COG3733	amine oxidase
AYR68_RS08000	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS08010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR68_RS08015	COG0183	Belongs to the thiolase family
AYR68_RS08020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR68_RS08025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR68_RS08035	COG4829	muconolactone delta-isomerase
AYR68_RS08040	COG4948	Mandelate Racemase Muconate Lactonizing
AYR68_RS08045	COG0583	DNA-binding transcription factor activity
AYR68_RS08055	COG2186	Transcriptional regulator
AYR68_RS08075	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS08095	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS08105	COG3829	transcription factor binding
AYR68_RS08115	COG3162	membrane
AYR68_RS08130	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS08145	COG0753	catalase activity
AYR68_RS08170	COG1846	Transcriptional regulator
AYR68_RS08175	COG1902	pentaerythritol trinitrate reductase activity
AYR68_RS08175	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR68_RS08185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYR68_RS08215	COG1309	transcriptional regulator
AYR68_RS08225	COG1335	isochorismatase
AYR68_RS08230	COG0583	DNA-binding transcription factor activity
AYR68_RS08240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR68_RS08240	COG0475	glutathione-regulated potassium exporter activity
AYR68_RS08250	COG1473	amidohydrolase
AYR68_RS08260	COG2831	hemolysin activation secretion protein
AYR68_RS08265	COG3210	domain, Protein
AYR68_RS08295	COG2188	Transcriptional regulator
AYR68_RS08310	COG0583	DNA-binding transcription factor activity
AYR68_RS08340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR68_RS08375	COG4372	Transposase
AYR68_RS08380	COG1566	PFAM secretion protein HlyD family protein
AYR68_RS08395	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS08400	COG0129	dihydroxy-acid dehydratase activity
AYR68_RS08410	COG0583	DNA-binding transcription factor activity
AYR68_RS08415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYR68_RS08425	COG2084	Dehydrogenase
AYR68_RS08430	COG2207	Transcriptional regulator
AYR68_RS08445	COG1064	alcohol dehydrogenase
AYR68_RS08455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR68_RS08460	COG1120	ATPase activity
AYR68_RS08480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR68_RS08595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AYR68_RS08645	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS08665	COG0745	RESPONSE REGULATOR receiver
AYR68_RS08670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS08675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR68_RS08680	COG1538	Outer membrane efflux protein
AYR68_RS08690	COG2072	flavoprotein involved in K transport
AYR68_RS08710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR68_RS08730	COG3539	Fimbrial protein
AYR68_RS08765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYR68_RS08775	COG0753	catalase activity
AYR68_RS08790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR68_RS08850	COG3433	isochorismatase activity
AYR68_RS08850	COG1535	isochorismatase
AYR68_RS08855	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS08860	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AYR68_RS08865	COG4149	molybdate abc transporter
AYR68_RS08870	COG0725	ABC transporter, periplasmic molybdate-binding protein
AYR68_RS08880	COG4638	Rieske (2fe-2S)
AYR68_RS08885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR68_RS08890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR68_RS08890	COG0543	2 iron, 2 sulfur cluster binding
AYR68_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS08930	COG2207	Transcriptional regulator
AYR68_RS08945	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS08950	COG2610	gluconate transmembrane transporter activity
AYR68_RS08960	COG0583	DNA-binding transcription factor activity
AYR68_RS08970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR68_RS08975	COG2031	fatty acid transporter
AYR68_RS08980	COG0183	Belongs to the thiolase family
AYR68_RS08985	COG0583	DNA-binding transcription factor activity
AYR68_RS08990	COG0583	DNA-binding transcription factor activity
AYR68_RS09005	COG1027	Aspartate ammonia-lyase
AYR68_RS09015	COG0477	Major facilitator Superfamily
AYR68_RS09035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR68_RS09040	COG4521	taurine ABC transporter
AYR68_RS09055	COG2188	Transcriptional regulator
AYR68_RS09065	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYR68_RS09070	COG1733	regulation of RNA biosynthetic process
AYR68_RS09075	COG2207	Transcriptional regulator
AYR68_RS09075	COG3708	Transcriptional regulator
AYR68_RS09090	COG0730	response to heat
AYR68_RS09100	COG3453	Protein conserved in bacteria
AYR68_RS09100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR68_RS09110	COG3781	membrane
AYR68_RS09115	COG1063	alcohol dehydrogenase
AYR68_RS09125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR68_RS09130	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR68_RS09135	COG0022	dehydrogenase e1 component
AYR68_RS09140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYR68_RS09145	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR68_RS09160	COG3706	GGDEF domain
AYR68_RS09175	COG0133	tryptophan synthase activity
AYR68_RS09185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR68_RS09220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYR68_RS09245	COG2226	methyltransferase
AYR68_RS09300	COG0842	Transport permease protein
AYR68_RS09305	COG0842	Transport permease protein
AYR68_RS09310	COG1131	(ABC) transporter
AYR68_RS09325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR68_RS09330	COG4773	Receptor
AYR68_RS09350	COG0730	response to heat
AYR68_RS09355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYR68_RS09375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AYR68_RS09390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR68_RS09430	COG4264	IucA IucC family
AYR68_RS09435	COG4264	IucA IucC family
AYR68_RS09455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYR68_RS09470	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS09475	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS09480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR68_RS09485	COG2207	Transcriptional regulator
AYR68_RS09490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR68_RS09495	COG0776	regulation of translation
AYR68_RS09520	COG0822	iron-sulfur transferase activity
AYR68_RS09525	COG0316	Belongs to the HesB IscA family
AYR68_RS09555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYR68_RS09575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR68_RS09580	COG0702	epimerase
AYR68_RS09615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYR68_RS09625	COG0339	signal peptide processing
AYR68_RS09670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYR68_RS09675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AYR68_RS09705	COG0776	regulation of translation
AYR68_RS09770	COG0084	hydrolase, TatD family'
AYR68_RS09790	COG1663	tetraacyldisaccharide 4'-kinase activity
AYR68_RS09795	COG1132	(ABC) transporter
AYR68_RS09805	COG0811	peptide transport
AYR68_RS09810	COG1475	DNA binding
AYR68_RS09815	COG1192	Involved in chromosome partitioning
AYR68_RS09825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYR68_RS09840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR68_RS09845	COG0191	fructose-bisphosphate aldolase activity
AYR68_RS09865	COG0424	maF-like protein
AYR68_RS09870	COG2850	peptidyl-arginine hydroxylation
AYR68_RS09880	COG0640	Transcriptional regulator
AYR68_RS09890	COG3619	membrane
AYR68_RS09895	COG3122	Protein conserved in bacteria
AYR68_RS09900	COG1132	(ABC) transporter
AYR68_RS09920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYR68_RS09925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR68_RS09935	COG0506	proline dehydrogenase activity
AYR68_RS09935	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR68_RS09935	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR68_RS09940	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYR68_RS09955	COG3698	Phosphodiester glycosidase
AYR68_RS09965	COG2353	YceI-like domain
AYR68_RS09975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYR68_RS10020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYR68_RS10020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYR68_RS10045	COG3539	Fimbrial protein
AYR68_RS10050	COG3121	Chaperone
AYR68_RS10075	COG0697	spore germination
AYR68_RS10085	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR68_RS10095	COG0583	DNA-binding transcription factor activity
AYR68_RS10130	COG1309	transcriptional regulator
AYR68_RS10145	COG1522	sequence-specific DNA binding
AYR68_RS10155	COG1126	abc transporter atp-binding protein
AYR68_RS10160	COG0765	amino acid transport
AYR68_RS10165	COG0765	amino acid transport
AYR68_RS10195	COG1464	Belongs to the NlpA lipoprotein family
AYR68_RS10205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR68_RS10210	COG2011	ABC-type metal ion transport system permease component
AYR68_RS10215	COG0012	GTP binding
AYR68_RS10240	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR68_RS10280	COG0386	Belongs to the glutathione peroxidase family
AYR68_RS10290	COG0436	Aminotransferase
AYR68_RS10330	COG3634	alkyl hydroperoxide reductase activity
AYR68_RS10345	COG0583	DNA-binding transcription factor activity
AYR68_RS10350	COG0798	PFAM Bile acid sodium symporter
AYR68_RS10380	COG4372	Transposase
AYR68_RS10400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYR68_RS10410	COG2137	regulation of response to DNA damage stimulus
AYR68_RS10425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR68_RS10460	COG0575	Belongs to the CDS family
AYR68_RS10465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYR68_RS10485	COG3852	Histidine kinase
AYR68_RS10500	COG3852	Histidine kinase
AYR68_RS10505	COG2204	response regulator
AYR68_RS10570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR68_RS10575	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AYR68_RS10595	COG0697	spore germination
AYR68_RS10600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR68_RS10610	COG0303	'Molybdopterin
AYR68_RS10615	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYR68_RS10615	COG0315	cyclic pyranopterin monophosphate synthase activity
AYR68_RS10630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AYR68_RS10635	COG0243	molybdopterin cofactor binding
AYR68_RS10645	COG0243	molybdopterin cofactor binding
AYR68_RS10650	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR68_RS10655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR68_RS10655	COG2146	nitrite reductase [NAD(P)H] activity
AYR68_RS10665	COG0745	RESPONSE REGULATOR receiver
AYR68_RS10670	COG1116	anion transmembrane transporter activity
AYR68_RS10670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR68_RS10685	COG0511	ligase activity, forming carbon-carbon bonds
AYR68_RS10700	COG2814	Major facilitator Superfamily
AYR68_RS10740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYR68_RS10750	COG1454	alcohol dehydrogenase
AYR68_RS10755	COG0824	Thioesterase
AYR68_RS10765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYR68_RS10780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR68_RS10785	COG2030	dehydratase
AYR68_RS10795	COG0183	Belongs to the thiolase family
AYR68_RS10805	COG0583	DNA-binding transcription factor activity
AYR68_RS10810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYR68_RS10820	COG1522	sequence-specific DNA binding
AYR68_RS10825	COG3135	benzoate transporter
AYR68_RS10835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYR68_RS10855	COG0589	response to stress
AYR68_RS10860	COG0488	(ABC) transporter
AYR68_RS10880	COG4773	Receptor
AYR68_RS10910	COG0668	transmembrane transport
AYR68_RS10920	COG1309	transcriptional regulator
AYR68_RS10935	COG1605	Chorismate mutase
AYR68_RS10945	COG4221	oxidoreductase activity
AYR68_RS10955	COG0308	aminopeptidase N
AYR68_RS10975	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AYR68_RS10985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR68_RS10990	COG1454	alcohol dehydrogenase
AYR68_RS11010	COG0531	amino acid
AYR68_RS11015	COG4303	Ethanolamine ammonia lyase large subunit
AYR68_RS11020	COG4302	ethanolamine ammonia-lyase activity
AYR68_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
AYR68_RS11025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR68_RS11030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR68_RS11040	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR68_RS11055	COG0697	spore germination
AYR68_RS11060	COG1923	regulation of RNA biosynthetic process
AYR68_RS11070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYR68_RS11075	COG0802	atpase or kinase
AYR68_RS11095	COG1187	pseudouridine synthase activity
AYR68_RS11110	COG0583	DNA-binding transcription factor activity
AYR68_RS11125	COG2814	Major facilitator Superfamily
AYR68_RS11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR68_RS11155	COG0729	surface antigen
AYR68_RS11175	COG0174	glutamine synthetase
AYR68_RS11180	COG0745	RESPONSE REGULATOR receiver
AYR68_RS11185	COG2205	protein histidine kinase activity
AYR68_RS11195	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AYR68_RS11200	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYR68_RS11225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR68_RS11230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR68_RS11235	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS11265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR68_RS11270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR68_RS11290	COG0583	DNA-binding transcription factor activity
AYR68_RS11305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR68_RS11315	COG3658	cytochrome
AYR68_RS11320	COG1215	transferase activity, transferring glycosyl groups
AYR68_RS11325	COG1649	PFAM Uncharacterised BCR, COG1649
AYR68_RS11325	COG0726	polysaccharide deacetylase
AYR68_RS11350	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYR68_RS11355	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYR68_RS11365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AYR68_RS11390	COG0305	Participates in initiation and elongation during chromosome replication
AYR68_RS11395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYR68_RS11405	COG1305	Transglutaminase-like
AYR68_RS11415	COG2308	Evidence 4 Homologs of previously reported genes of
AYR68_RS11445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AYR68_RS11450	COG0138	bifunctional purine biosynthesis protein purh
AYR68_RS11455	COG0151	Belongs to the GarS family
AYR68_RS11460	COG1464	Belongs to the NlpA lipoprotein family
AYR68_RS11465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR68_RS11470	COG2011	ABC-type metal ion transport system permease component
AYR68_RS11475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR68_RS11485	COG1301	dicarboxylic acid transport
AYR68_RS11515	COG1794	racemase activity, acting on amino acids and derivatives
AYR68_RS11525	COG3008	intermembrane lipid transfer
AYR68_RS11525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYR68_RS11530	COG2995	paraquat-inducible protein a
AYR68_RS11540	COG2985	domain, Protein
AYR68_RS11565	COG0477	Major facilitator Superfamily
AYR68_RS11615	COG2186	Transcriptional regulator
AYR68_RS11625	COG0786	glutamate:sodium symporter activity
AYR68_RS11630	COG3243	poly(R)-hydroxyalkanoic acid synthase
AYR68_RS11655	COG3111	PFAM Bacterial OB fold (BOF) protein
AYR68_RS11755	COG1610	YqeY-like protein
AYR68_RS11760	COG4783	chaperone-mediated protein folding
AYR68_RS11785	COG1286	toxin biosynthetic process
AYR68_RS11815	COG0778	Nitroreductase
AYR68_RS11825	COG0513	Belongs to the DEAD box helicase family
AYR68_RS11845	COG2363	Small membrane protein
AYR68_RS11875	COG1234	tRNA 3'-trailer cleavage
AYR68_RS11880	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYR68_RS11890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYR68_RS11900	COG2819	hydrolase of the alpha beta superfamily
AYR68_RS11905	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS11910	COG1301	dicarboxylic acid transport
AYR68_RS11915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYR68_RS11920	COG3139	Protein of unknown function (DUF1315)
AYR68_RS11925	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYR68_RS11930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR68_RS11940	COG0494	nUDIX hydrolase
AYR68_RS11950	COG0642	Histidine kinase
AYR68_RS11965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYR68_RS11975	COG1720	tRNA m6t6A37 methyltransferase activity
AYR68_RS11990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR68_RS11995	COG0826	peptidase U32
AYR68_RS12000	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR68_RS12010	COG4598	ABC transporter
AYR68_RS12015	COG4160	amino acid transport
AYR68_RS12020	COG4215	(ABC) transporter
AYR68_RS12055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS12100	COG1131	(ABC) transporter
AYR68_RS12105	COG0842	Transport permease protein
AYR68_RS12120	COG0772	Belongs to the SEDS family
AYR68_RS12125	COG2951	lytic endotransglycosylase activity
AYR68_RS12150	COG2207	Transcriptional regulator
AYR68_RS12165	COG0052	Belongs to the universal ribosomal protein uS2 family
AYR68_RS12170	COG0024	Methionine aminopeptidase
AYR68_RS12180	COG2223	nitrite transmembrane transporter activity
AYR68_RS12195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR68_RS12200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR68_RS12205	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS12220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYR68_RS12225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYR68_RS12230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR68_RS12250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR68_RS12255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYR68_RS12260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYR68_RS12295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYR68_RS12305	COG0174	glutamine synthetase
AYR68_RS12320	COG0512	Glutamine amidotransferase of anthranilate synthase
AYR68_RS12355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYR68_RS12365	COG0302	gtp cyclohydrolase
AYR68_RS12385	COG3739	integral membrane protein
AYR68_RS12400	COG1169	isochorismate synthase
AYR68_RS12410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AYR68_RS12415	COG1132	(ABC) transporter
AYR68_RS12420	COG1132	(ABC) transporter
AYR68_RS12435	COG3433	isochorismatase activity
AYR68_RS12435	COG1535	isochorismatase
AYR68_RS12440	COG1021	2,3-dihydroxybenzoate-AMP ligase
AYR68_RS12445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR68_RS12455	COG4774	siderophore transport
AYR68_RS12460	COG4607	ABC-type enterochelin transport system periplasmic component
AYR68_RS12465	COG4604	ABC transporter, ATP-binding protein
AYR68_RS12470	COG4605	iron ion homeostasis
AYR68_RS12475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR68_RS12480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR68_RS12495	COG2964	Protein conserved in bacteria
AYR68_RS12505	COG1741	Belongs to the pirin family
AYR68_RS12520	COG1309	transcriptional regulator
AYR68_RS12530	COG4948	Mandelate Racemase Muconate Lactonizing
AYR68_RS12535	COG2814	Major facilitator Superfamily
AYR68_RS12570	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYR68_RS12570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR68_RS12575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR68_RS12580	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS12590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR68_RS12595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR68_RS12600	COG0583	DNA-binding transcription factor activity
AYR68_RS12605	COG1113	amino acid transport
AYR68_RS12620	COG4372	Transposase
AYR68_RS12625	COG1113	amino acid transport
AYR68_RS12645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AYR68_RS12645	COG2508	Transcriptional regulator
AYR68_RS12675	COG2879	small protein
AYR68_RS12680	COG1966	Carbon starvation protein
AYR68_RS12725	COG1067	ATP-dependent peptidase activity
AYR68_RS12730	COG0583	DNA-binding transcription factor activity
AYR68_RS12755	COG1686	Belongs to the peptidase S11 family
AYR68_RS12760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AYR68_RS12795	COG0616	signal peptide processing
AYR68_RS12800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYR68_RS12810	COG0573	inorganic phosphate transmembrane transporter activity
AYR68_RS12815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR68_RS12820	COG1113	amino acid transport
AYR68_RS12825	COG3961	Belongs to the TPP enzyme family
AYR68_RS12830	COG1522	sequence-specific DNA binding
AYR68_RS12840	COG0076	glutamate decarboxylase activity
AYR68_RS12845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR68_RS12855	COG1309	transcriptional regulator
AYR68_RS12870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR68_RS12905	COG0352	thiamine-phosphate diphosphorylase activity
AYR68_RS12930	COG0612	Peptidase, M16
AYR68_RS12940	COG1823	symporter activity
AYR68_RS12945	COG0583	DNA-binding transcription factor activity
AYR68_RS12950	COG0477	Major facilitator Superfamily
AYR68_RS12970	COG1187	pseudouridine synthase activity
AYR68_RS12985	COG1686	Belongs to the peptidase S11 family
AYR68_RS12990	COG1252	NADH dehydrogenase
AYR68_RS13000	COG0415	Belongs to the DNA photolyase family
AYR68_RS13015	COG1215	transferase activity, transferring glycosyl groups
AYR68_RS13045	COG2070	2-Nitropropane dioxygenase
AYR68_RS13235	COG5410	chromosome segregation
AYR68_RS13430	COG0556	nucleotide-excision repair
AYR68_RS13450	COG0436	Aminotransferase
AYR68_RS13475	COG4221	oxidoreductase activity
AYR68_RS13485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AYR68_RS13490	COG1381	Involved in DNA repair and RecF pathway recombination
AYR68_RS13500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYR68_RS13515	COG0681	Belongs to the peptidase S26 family
AYR68_RS13530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR68_RS13550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYR68_RS13555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYR68_RS13560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AYR68_RS13570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AYR68_RS13575	COG4208	sulfate ABC transporter
AYR68_RS13580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AYR68_RS13585	COG0583	DNA-binding transcription factor activity
AYR68_RS13590	COG4625	pathogenesis
AYR68_RS13605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AYR68_RS13620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYR68_RS13630	COG1051	belongs to the nudix hydrolase family
AYR68_RS13630	COG1056	cytidyltransferase-related domain
AYR68_RS13635	COG1024	Enoyl-CoA hydratase
AYR68_RS13650	COG2814	Major facilitator Superfamily
AYR68_RS13655	COG0047	phosphoribosylformylglycinamidine synthase activity
AYR68_RS13655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYR68_RS13675	COG1473	amidohydrolase
AYR68_RS13680	COG0824	Thioesterase
AYR68_RS13700	COG0823	Involved in the tonB-independent uptake of proteins
AYR68_RS13720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR68_RS13755	COG0628	permease
AYR68_RS13765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYR68_RS13770	COG0596	Alpha beta hydrolase
AYR68_RS13775	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYR68_RS13775	COG0616	signal peptide processing
AYR68_RS13785	COG0658	competence protein
AYR68_RS13785	COG2333	competence protein COMEC
AYR68_RS13790	COG1136	(ABC) transporter
AYR68_RS13795	COG4591	ABC-type transport system involved in lipoprotein release permease component
AYR68_RS13825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS13845	COG0463	Glycosyl transferase, family 2
AYR68_RS13890	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYR68_RS13895	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS13905	COG0019	diaminopimelate decarboxylase activity
AYR68_RS13915	COG1113	amino acid transport
AYR68_RS13930	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AYR68_RS13940	COG3339	Conserved Protein
AYR68_RS13945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYR68_RS13950	COG0243	molybdopterin cofactor binding
AYR68_RS13955	COG1929	Belongs to the glycerate kinase type-1 family
AYR68_RS13970	COG0778	Nitroreductase
AYR68_RS13995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR68_RS14010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYR68_RS14030	COG0741	lytic transglycosylase activity
AYR68_RS14050	COG0584	glycerophosphoryl diester phosphodiesterase
AYR68_RS14055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR68_RS14080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR68_RS14085	COG1597	lipid kinase activity
AYR68_RS14100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYR68_RS14105	COG0477	Major facilitator Superfamily
AYR68_RS14155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYR68_RS14160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR68_RS14185	COG0505	Belongs to the CarA family
AYR68_RS14205	COG0589	response to stress
AYR68_RS14220	COG2843	Capsule synthesis protein
AYR68_RS14245	COG2321	neutral zinc metallopeptidase
AYR68_RS14250	COG2354	Protein conserved in bacteria
AYR68_RS14270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR68_RS14285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYR68_RS14290	COG1053	succinate dehydrogenase
AYR68_RS14295	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AYR68_RS14300	COG2009	succinate dehydrogenase
AYR68_RS14340	COG2921	Belongs to the UPF0250 family
AYR68_RS14345	COG0321	lipoyl(octanoyl) transferase activity
AYR68_RS14360	COG0531	amino acid
AYR68_RS14370	COG1733	regulation of RNA biosynthetic process
AYR68_RS14375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYR68_RS14380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYR68_RS14380	COG1648	precorrin-2 dehydrogenase activity
AYR68_RS14395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AYR68_RS14425	COG0671	phosphoesterase, PA-phosphatase related
AYR68_RS14430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR68_RS14440	COG1538	Outer membrane efflux protein
AYR68_RS14445	COG0393	Putative heavy-metal-binding
AYR68_RS14450	COG0393	Putative heavy-metal-binding
AYR68_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS14470	COG0525	valine-tRNA ligase activity
AYR68_RS14490	COG0583	DNA-binding transcription factor activity
AYR68_RS14495	COG0004	ammonium transporteR
AYR68_RS14505	COG0642	Histidine kinase
AYR68_RS14510	COG0745	RESPONSE REGULATOR receiver
AYR68_RS14515	COG2194	sulfuric ester hydrolase activity
AYR68_RS14555	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR68_RS14570	COG2315	Protein conserved in bacteria
AYR68_RS14575	COG0142	geranyltranstransferase activity
AYR68_RS14580	COG2828	Protein conserved in bacteria
AYR68_RS14585	COG1113	amino acid transport
AYR68_RS14605	COG2207	Transcriptional regulator
AYR68_RS14630	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR68_RS14640	COG0560	Phosphoserine phosphatase
AYR68_RS14650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR68_RS14660	COG1530	ribonuclease E activity
AYR68_RS14665	COG0424	maF-like protein
AYR68_RS14670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AYR68_RS14675	COG1792	Involved in formation and maintenance of cell shape
AYR68_RS14680	COG1077	Cell shape determining protein MreB Mrl
AYR68_RS14685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR68_RS14695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR68_RS14725	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AYR68_RS14730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR68_RS14735	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR68_RS14740	COG1115	amino acid carrier protein
AYR68_RS14755	COG2814	Major facilitator Superfamily
AYR68_RS14760	COG1289	transmembrane transporter activity
AYR68_RS14770	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYR68_RS14810	COG1376	ErfK ybiS ycfS ynhG family protein
AYR68_RS14815	COG2832	Protein of unknown function (DUF454)
AYR68_RS14825	COG5510	response to toxic substance
AYR68_RS14845	COG0840	transmembrane signaling receptor activity
AYR68_RS14885	COG3422	double-strand break repair
AYR68_RS14890	COG2824	Alkylphosphonate utilization operon protein PhnA
AYR68_RS14895	COG3189	MarR family transcriptional regulator
AYR68_RS14905	COG0354	folic acid binding
AYR68_RS14910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR68_RS14920	COG0679	Auxin Efflux Carrier
AYR68_RS14925	COG1902	pentaerythritol trinitrate reductase activity
AYR68_RS14930	COG4772	TonB-dependent receptor
AYR68_RS14935	COG2094	Belongs to the DNA glycosylase MPG family
AYR68_RS14960	COG1217	gtp-binding protein TYPA
AYR68_RS14965	COG2233	PERMEase
AYR68_RS14975	COG0833	amino acid
AYR68_RS14980	COG1690	Belongs to the RtcB family
AYR68_RS14990	COG2885	chlorophyll binding
AYR68_RS14990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYR68_RS15000	COG0183	Belongs to the thiolase family
AYR68_RS15020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR68_RS15040	COG2207	Transcriptional regulator
AYR68_RS15045	COG0183	Belongs to the thiolase family
AYR68_RS15075	COG1272	protein, Hemolysin III
AYR68_RS15080	COG0477	Major facilitator Superfamily
AYR68_RS15095	COG0450	alkyl hydroperoxide reductase
AYR68_RS15115	COG0285	dihydrofolate synthase activity
AYR68_RS15165	COG2096	Adenosyltransferase
AYR68_RS15185	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYR68_RS15190	COG0745	RESPONSE REGULATOR receiver
AYR68_RS15195	COG2205	protein histidine kinase activity
AYR68_RS15205	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS15210	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS15215	COG0583	DNA-binding transcription factor activity
AYR68_RS15220	COG0625	glutathione transferase activity
AYR68_RS15285	COG0438	transferase activity, transferring glycosyl groups
AYR68_RS15290	COG0463	Glycosyl transferase, family 2
AYR68_RS15295	COG0726	polysaccharide deacetylase
AYR68_RS15315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYR68_RS15320	COG2205	protein histidine kinase activity
AYR68_RS15365	COG1862	Preprotein translocase
AYR68_RS15375	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYR68_RS15380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYR68_RS15390	COG3781	membrane
AYR68_RS15395	COG0613	PHP domain protein
AYR68_RS15405	COG2350	Protein conserved in bacteria
AYR68_RS15435	COG1607	acyl-coa hydrolase
AYR68_RS15495	COG2199	diguanylate cyclase activity
AYR68_RS15505	COG1408	metallophosphoesterase
AYR68_RS15510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR68_RS15520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYR68_RS15540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AYR68_RS15545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYR68_RS15560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYR68_RS15570	COG2969	positive regulation of protein catabolic process
AYR68_RS15590	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS15595	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR68_RS15610	COG1309	transcriptional regulator
AYR68_RS15615	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS15660	COG1183	phosphatidylcholine synthase activity
AYR68_RS15665	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AYR68_RS15695	COG1196	nuclear chromosome segregation
AYR68_RS15695	COG0741	lytic transglycosylase activity
AYR68_RS15695	COG0739	heme binding
AYR68_RS15705	COG1702	phosphate starvation-inducible protein PhoH
AYR68_RS15740	COG1295	ribonuclease BN
AYR68_RS15745	COG0697	spore germination
AYR68_RS15750	COG2169	Transcriptional regulator
AYR68_RS15755	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYR68_RS15800	COG0557	exoribonuclease II activity
AYR68_RS15805	COG0339	signal peptide processing
AYR68_RS15810	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AYR68_RS15840	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AYR68_RS15845	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS16000	COG0626	cystathionine gamma-synthase activity
AYR68_RS16005	COG0433	COG0433 Predicted ATPase
AYR68_RS16010	COG1017	nitric oxide dioxygenase activity
AYR68_RS16010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR68_RS16015	COG1959	2 iron, 2 sulfur cluster binding
AYR68_RS16030	COG1301	dicarboxylic acid transport
AYR68_RS16035	COG1946	Acyl-CoA thioesterase
AYR68_RS16055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYR68_RS16060	COG1040	competence protein
AYR68_RS16065	COG0494	nUDIX hydrolase
AYR68_RS16075	COG0598	Magnesium transport protein CorA
AYR68_RS16085	COG2854	intermembrane phospholipid transfer
AYR68_RS16095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYR68_RS16100	COG1127	ABC transporter
AYR68_RS16110	COG0513	Belongs to the DEAD box helicase family
AYR68_RS16130	COG0408	coproporphyrinogen oxidase activity
AYR68_RS16145	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS16155	COG1983	PspC domain protein
AYR68_RS16160	COG0517	IMP dehydrogenase activity
AYR68_RS16205	COG0583	DNA-binding transcription factor activity
AYR68_RS16245	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS16255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR68_RS16260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR68_RS16265	COG0833	amino acid
AYR68_RS16295	COG1192	Involved in chromosome partitioning
AYR68_RS16300	COG0628	permease
AYR68_RS16310	COG1289	transmembrane transporter activity
AYR68_RS16325	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR68_RS16330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AYR68_RS16340	COG0277	FAD linked oxidase domain protein
AYR68_RS16345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYR68_RS16385	COG1061	Type III restriction enzyme res subunit
AYR68_RS16395	COG1192	Involved in chromosome partitioning
AYR68_RS16400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR68_RS16410	COG1061	Type III restriction enzyme res subunit
AYR68_RS16430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYR68_RS16435	COG5380	lipid catabolic process
AYR68_RS16455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYR68_RS16505	COG0194	GDP metabolic process
AYR68_RS16515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR68_RS16535	COG3307	-O-antigen
AYR68_RS16540	COG4969	Belongs to the N-Me-Phe pilin family
AYR68_RS16550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AYR68_RS16555	COG1704	LemA family
AYR68_RS16565	COG0493	'glutamate synthase
AYR68_RS16570	COG0069	glutamate synthase activity
AYR68_RS16570	COG0067	glutamate synthase
AYR68_RS16570	COG0070	glutamate synthase
AYR68_RS16620	COG2226	methyltransferase
AYR68_RS16635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYR68_RS16640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYR68_RS16685	COG0833	amino acid
AYR68_RS16765	COG0488	(ABC) transporter
AYR68_RS16770	COG2873	o-acetylhomoserine
AYR68_RS16775	COG4221	oxidoreductase activity
AYR68_RS16780	COG0659	secondary active sulfate transmembrane transporter activity
AYR68_RS16800	COG0427	acetyl-CoA hydrolase
AYR68_RS16830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYR68_RS16860	COG2329	Antibiotic biosynthesis monooxygenase
AYR68_RS16875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AYR68_RS16940	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR68_RS16945	COG1733	regulation of RNA biosynthetic process
AYR68_RS16975	COG0667	Aldo Keto reductase
AYR68_RS16995	COG0583	DNA-binding transcription factor activity
AYR68_RS17000	COG2814	Major facilitator Superfamily
AYR68_RS17030	COG1335	isochorismatase
AYR68_RS17040	COG1012	belongs to the aldehyde dehydrogenase family
AYR68_RS17045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR68_RS17055	COG1113	amino acid transport
AYR68_RS17065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR68_RS17080	COG2814	Major facilitator Superfamily
AYR68_RS17090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR68_RS17090	COG0352	thiamine-phosphate diphosphorylase activity
AYR68_RS17090	COG0351	phosphomethylpyrimidine kinase
AYR68_RS17110	COG1309	transcriptional regulator
AYR68_RS17115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYR68_RS17135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR68_RS17145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR68_RS17150	COG3162	membrane
AYR68_RS17155	COG2198	Histidine kinase
AYR68_RS17155	COG2205	protein histidine kinase activity
AYR68_RS17155	COG0784	Response regulator, receiver
AYR68_RS17180	COG3328	transposase activity
AYR68_RS17185	COG1522	sequence-specific DNA binding
AYR68_RS17190	COG1335	isochorismatase
AYR68_RS17195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR68_RS17205	COG0668	transmembrane transport
AYR68_RS17210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR68_RS17215	COG1519	Transferase
AYR68_RS17220	COG1902	pentaerythritol trinitrate reductase activity
AYR68_RS17240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYR68_RS17265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR68_RS17265	COG0426	domain, Protein
AYR68_RS17270	COG4774	siderophore transport
AYR68_RS17275	COG2119	membrane
AYR68_RS17285	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR68_RS17295	COG4942	peptidase
AYR68_RS17310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYR68_RS17320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYR68_RS17340	COG0189	ligase activity
AYR68_RS17360	COG0708	Exodeoxyribonuclease III
AYR68_RS17365	COG1393	Belongs to the ArsC family
AYR68_RS17380	COG3706	GGDEF domain
AYR68_RS17415	COG2351	hydroxyisourate hydrolase activity
AYR68_RS17420	COG2233	PERMEase
AYR68_RS17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR68_RS17440	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AYR68_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS17455	COG3150	esterase
AYR68_RS17475	COG0791	NLP P60 protein
AYR68_RS17475	COG1388	LysM domain
AYR68_RS17490	COG2918	glutathione biosynthetic process
AYR68_RS17505	COG2733	membrane
AYR68_RS17510	COG0436	Aminotransferase
AYR68_RS17515	COG0534	Mate efflux family protein
AYR68_RS17615	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYR68_RS17620	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYR68_RS17630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYR68_RS17635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR68_RS17690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR68_RS17740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYR68_RS17770	COG0659	secondary active sulfate transmembrane transporter activity
AYR68_RS17775	COG0589	response to stress
AYR68_RS17805	COG0606	chelatase, subunit chli
AYR68_RS17810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR68_RS17820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR68_RS17835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYR68_RS17850	COG0318	PFAM AMP-dependent synthetase and ligase
AYR68_RS17860	COG0477	Major facilitator Superfamily
AYR68_RS17865	COG2860	membrane
AYR68_RS17875	COG1253	flavin adenine dinucleotide binding
AYR68_RS17895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYR68_RS17930	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYR68_RS17940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AYR68_RS17975	COG1309	transcriptional regulator
AYR68_RS18010	COG0758	DNA mediated transformation
AYR68_RS18020	COG0697	spore germination
AYR68_RS18025	COG1309	transcriptional regulator
AYR68_RS18040	COG0386	Belongs to the glutathione peroxidase family
AYR68_RS18105	COG1121	(ABC) transporter
AYR68_RS18110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYR68_RS18115	COG1280	lysine exporter protein (LysE YggA)
AYR68_RS18120	COG2837	iron assimilation
AYR68_RS18130	COG0281	malic enzyme
AYR68_RS18175	COG0519	Catalyzes the synthesis of GMP from XMP
AYR68_RS18175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR68_RS18180	COG4399	Belongs to the UPF0754 family
AYR68_RS18185	COG2259	Doxx family
AYR68_RS18190	COG0586	Pfam SNARE associated Golgi protein
AYR68_RS18205	COG1192	Involved in chromosome partitioning
AYR68_RS18215	COG0271	Belongs to the BolA IbaG family
AYR68_RS18235	COG2267	carboxylic ester hydrolase activity
AYR68_RS18250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR68_RS18260	COG4221	oxidoreductase activity
AYR68_RS18260	COG3321	synthase
AYR68_RS18260	COG0300	oxidoreductase activity
AYR68_RS18260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR68_RS18265	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS18275	COG2197	response regulator
AYR68_RS18285	COG3916	Acyl-homoserine-lactone synthase
AYR68_RS18290	COG0477	Major facilitator Superfamily
AYR68_RS18295	COG1024	Enoyl-CoA hydratase
AYR68_RS18300	COG1024	Enoyl-CoA hydratase
AYR68_RS18305	COG1960	acyl-CoA dehydrogenase activity
AYR68_RS18310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR68_RS18330	COG1113	amino acid transport
AYR68_RS18335	COG1113	amino acid transport
AYR68_RS18340	COG0251	oxidation-reduction process
AYR68_RS18380	COG0564	pseudouridine synthase activity
AYR68_RS18430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYR68_RS18445	COG1802	Transcriptional regulator
AYR68_RS18450	COG1448	Aminotransferase
AYR68_RS18455	COG0277	FAD linked oxidase domain protein
AYR68_RS18465	COG2186	Transcriptional regulator
AYR68_RS18475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR68_RS18480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR68_RS18495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYR68_RS18505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYR68_RS18515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYR68_RS18520	COG0438	transferase activity, transferring glycosyl groups
AYR68_RS18540	COG1216	Glycosyl transferase, family 2
AYR68_RS18545	COG5039	Polysaccharide pyruvyl transferase
AYR68_RS18555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYR68_RS18560	COG1596	polysaccharide export
AYR68_RS18585	COG0728	peptidoglycan biosynthetic process
AYR68_RS18590	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYR68_RS18645	COG0546	phosphoglycolate phosphatase activity
AYR68_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
AYR68_RS18670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR68_RS18675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR68_RS18680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR68_RS18685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR68_RS18690	COG1116	anion transmembrane transporter activity
AYR68_RS18695	COG1309	transcriptional regulator
AYR68_RS18700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYR68_RS18710	COG0196	riboflavin kinase activity
AYR68_RS18715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYR68_RS18725	COG1047	Peptidyl-prolyl cis-trans
AYR68_RS18765	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYR68_RS18770	COG0657	acetylesterase activity
AYR68_RS18790	COG0583	DNA-binding transcription factor activity
AYR68_RS18820	COG2951	lytic endotransglycosylase activity
AYR68_RS18825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYR68_RS18840	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYR68_RS18850	COG0671	phosphoesterase, PA-phosphatase related
AYR68_RS18855	COG0861	Integral membrane protein TerC family
AYR68_RS18865	COG0754	glutathionylspermidine amidase activity
AYR68_RS18875	COG0402	S-adenosylhomocysteine deaminase activity
AYR68_RS18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR68_RS18900	COG1230	cation diffusion facilitator family transporter
AYR68_RS18915	COG0706	membrane insertase activity