locus-tag	class	description
AYR67_RS00010	COG0592	DNA-directed DNA polymerase activity
AYR67_RS00020	COG0187	DNA topoisomerase II activity
AYR67_RS00030	COG0586	Pfam SNARE associated Golgi protein
AYR67_RS00035	COG0488	(ABC) transporter
AYR67_RS00060	COG0596	Alpha beta hydrolase
AYR67_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AYR67_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYR67_RS00110	COG0733	neurotransmitter:sodium symporter activity
AYR67_RS00145	COG0583	DNA-binding transcription factor activity
AYR67_RS00150	COG2233	PERMEase
AYR67_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS00200	COG2814	Major facilitator Superfamily
AYR67_RS00205	COG0656	L-ascorbic acid biosynthetic process
AYR67_RS00210	COG0583	DNA-binding transcription factor activity
AYR67_RS00220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR67_RS00225	COG1064	alcohol dehydrogenase
AYR67_RS00230	COG2818	Glycosylase
AYR67_RS00245	COG1194	a g-specific adenine glycosylase
AYR67_RS00265	COG2983	Belongs to the UPF0260 family
AYR67_RS00270	COG2133	pyrroloquinoline quinone binding
AYR67_RS00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYR67_RS00280	COG2116	formate transmembrane transporter activity
AYR67_RS00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR67_RS00305	COG1335	isochorismatase
AYR67_RS00310	COG0385	Bile acid
AYR67_RS00315	COG0534	Mate efflux family protein
AYR67_RS00320	COG1683	Conserved Protein
AYR67_RS00340	COG0625	glutathione transferase activity
AYR67_RS00350	COG1113	amino acid transport
AYR67_RS00360	COG0523	cobalamin synthesis protein
AYR67_RS00370	COG2188	Transcriptional regulator
AYR67_RS00400	COG0010	Belongs to the arginase family
AYR67_RS00410	COG0546	phosphoglycolate phosphatase activity
AYR67_RS00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR67_RS00420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYR67_RS00430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYR67_RS00435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYR67_RS00520	COG0534	Mate efflux family protein
AYR67_RS00525	COG0436	Aminotransferase
AYR67_RS00530	COG2733	membrane
AYR67_RS00545	COG2918	glutathione biosynthetic process
AYR67_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS00580	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AYR67_RS00590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR67_RS00600	COG2233	PERMEase
AYR67_RS00605	COG2351	hydroxyisourate hydrolase activity
AYR67_RS00640	COG3706	GGDEF domain
AYR67_RS00655	COG1393	Belongs to the ArsC family
AYR67_RS00660	COG0708	Exodeoxyribonuclease III
AYR67_RS00680	COG0189	ligase activity
AYR67_RS00700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYR67_RS00710	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYR67_RS00725	COG4942	peptidase
AYR67_RS00735	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR67_RS00745	COG2119	membrane
AYR67_RS00750	COG4774	siderophore transport
AYR67_RS00755	COG0426	domain, Protein
AYR67_RS00755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR67_RS00780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYR67_RS00800	COG1902	pentaerythritol trinitrate reductase activity
AYR67_RS00805	COG1519	Transferase
AYR67_RS00810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR67_RS00815	COG0668	transmembrane transport
AYR67_RS00825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR67_RS00830	COG1335	isochorismatase
AYR67_RS00835	COG1522	sequence-specific DNA binding
AYR67_RS00860	COG0784	Response regulator, receiver
AYR67_RS00860	COG2198	Histidine kinase
AYR67_RS00860	COG2205	protein histidine kinase activity
AYR67_RS00865	COG3162	membrane
AYR67_RS00870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR67_RS00880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR67_RS00900	COG1309	transcriptional regulator
AYR67_RS00920	COG0352	thiamine-phosphate diphosphorylase activity
AYR67_RS00920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR67_RS00920	COG0351	phosphomethylpyrimidine kinase
AYR67_RS00930	COG2814	Major facilitator Superfamily
AYR67_RS00945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR67_RS00955	COG1113	amino acid transport
AYR67_RS00965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR67_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS00980	COG1335	isochorismatase
AYR67_RS01010	COG2814	Major facilitator Superfamily
AYR67_RS01015	COG0583	DNA-binding transcription factor activity
AYR67_RS01035	COG0667	Aldo Keto reductase
AYR67_RS01065	COG1733	regulation of RNA biosynthetic process
AYR67_RS01070	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR67_RS01135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AYR67_RS01150	COG2329	Antibiotic biosynthesis monooxygenase
AYR67_RS01180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYR67_RS01210	COG0427	acetyl-CoA hydrolase
AYR67_RS01230	COG0659	secondary active sulfate transmembrane transporter activity
AYR67_RS01235	COG4221	oxidoreductase activity
AYR67_RS01240	COG2873	o-acetylhomoserine
AYR67_RS01245	COG0488	(ABC) transporter
AYR67_RS01325	COG0833	amino acid
AYR67_RS01370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYR67_RS01375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYR67_RS01390	COG2226	methyltransferase
AYR67_RS01440	COG0070	glutamate synthase
AYR67_RS01440	COG0067	glutamate synthase
AYR67_RS01440	COG0069	glutamate synthase activity
AYR67_RS01445	COG0493	'glutamate synthase
AYR67_RS01455	COG1704	LemA family
AYR67_RS01460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AYR67_RS01480	COG3307	-O-antigen
AYR67_RS01500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR67_RS01510	COG0194	GDP metabolic process
AYR67_RS01560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYR67_RS01580	COG5380	lipid catabolic process
AYR67_RS01585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYR67_RS01610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYR67_RS01615	COG0277	FAD linked oxidase domain protein
AYR67_RS01625	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AYR67_RS01630	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR67_RS01645	COG1289	transmembrane transporter activity
AYR67_RS01655	COG0628	permease
AYR67_RS01660	COG1192	Involved in chromosome partitioning
AYR67_RS01690	COG0833	amino acid
AYR67_RS01695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR67_RS01700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR67_RS01710	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS01750	COG0583	DNA-binding transcription factor activity
AYR67_RS01795	COG0517	IMP dehydrogenase activity
AYR67_RS01800	COG1983	PspC domain protein
AYR67_RS01810	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS01825	COG0408	coproporphyrinogen oxidase activity
AYR67_RS01845	COG0513	Belongs to the DEAD box helicase family
AYR67_RS01855	COG1127	ABC transporter
AYR67_RS01860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYR67_RS01870	COG2854	intermembrane phospholipid transfer
AYR67_RS01880	COG0598	Magnesium transport protein CorA
AYR67_RS01890	COG0494	nUDIX hydrolase
AYR67_RS01895	COG1040	competence protein
AYR67_RS01900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYR67_RS01920	COG1946	Acyl-CoA thioesterase
AYR67_RS01925	COG1301	dicarboxylic acid transport
AYR67_RS01940	COG1959	2 iron, 2 sulfur cluster binding
AYR67_RS01945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR67_RS01945	COG1017	nitric oxide dioxygenase activity
AYR67_RS01950	COG0433	COG0433 Predicted ATPase
AYR67_RS01955	COG0626	cystathionine gamma-synthase activity
AYR67_RS02110	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS02115	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AYR67_RS02145	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AYR67_RS02150	COG0339	signal peptide processing
AYR67_RS02155	COG0557	exoribonuclease II activity
AYR67_RS02200	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYR67_RS02205	COG2169	Transcriptional regulator
AYR67_RS02210	COG0697	spore germination
AYR67_RS02215	COG1295	ribonuclease BN
AYR67_RS02250	COG1702	phosphate starvation-inducible protein PhoH
AYR67_RS02260	COG0741	lytic transglycosylase activity
AYR67_RS02260	COG0739	heme binding
AYR67_RS02260	COG1196	nuclear chromosome segregation
AYR67_RS02290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AYR67_RS02295	COG1183	phosphatidylcholine synthase activity
AYR67_RS02340	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS02345	COG1309	transcriptional regulator
AYR67_RS02360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR67_RS02365	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS02385	COG2969	positive regulation of protein catabolic process
AYR67_RS02395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYR67_RS02410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYR67_RS02415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AYR67_RS02435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYR67_RS02445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR67_RS02450	COG1408	metallophosphoesterase
AYR67_RS02460	COG2199	diguanylate cyclase activity
AYR67_RS02520	COG1607	acyl-coa hydrolase
AYR67_RS02550	COG2350	Protein conserved in bacteria
AYR67_RS02560	COG0613	PHP domain protein
AYR67_RS02565	COG3781	membrane
AYR67_RS02575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYR67_RS02580	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYR67_RS02590	COG1862	Preprotein translocase
AYR67_RS02620	COG2205	protein histidine kinase activity
AYR67_RS02625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYR67_RS02645	COG0726	polysaccharide deacetylase
AYR67_RS02650	COG0463	Glycosyl transferase, family 2
AYR67_RS02655	COG0438	transferase activity, transferring glycosyl groups
AYR67_RS02720	COG0625	glutathione transferase activity
AYR67_RS02725	COG0583	DNA-binding transcription factor activity
AYR67_RS02730	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS02735	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS02745	COG2205	protein histidine kinase activity
AYR67_RS02750	COG0745	RESPONSE REGULATOR receiver
AYR67_RS02755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYR67_RS02775	COG2096	Adenosyltransferase
AYR67_RS02825	COG0285	dihydrofolate synthase activity
AYR67_RS02845	COG0450	alkyl hydroperoxide reductase
AYR67_RS02860	COG0477	Major facilitator Superfamily
AYR67_RS02865	COG1272	protein, Hemolysin III
AYR67_RS02895	COG0183	Belongs to the thiolase family
AYR67_RS02900	COG2207	Transcriptional regulator
AYR67_RS02920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR67_RS02940	COG0183	Belongs to the thiolase family
AYR67_RS02950	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYR67_RS02950	COG2885	chlorophyll binding
AYR67_RS02960	COG1690	Belongs to the RtcB family
AYR67_RS02965	COG0833	amino acid
AYR67_RS02975	COG2233	PERMEase
AYR67_RS02980	COG1217	gtp-binding protein TYPA
AYR67_RS03005	COG2094	Belongs to the DNA glycosylase MPG family
AYR67_RS03010	COG4772	TonB-dependent receptor
AYR67_RS03025	COG4772	TonB-dependent receptor
AYR67_RS03030	COG1902	pentaerythritol trinitrate reductase activity
AYR67_RS03035	COG0679	Auxin Efflux Carrier
AYR67_RS03045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR67_RS03050	COG0354	folic acid binding
AYR67_RS03060	COG3189	MarR family transcriptional regulator
AYR67_RS03065	COG2824	Alkylphosphonate utilization operon protein PhnA
AYR67_RS03070	COG3422	double-strand break repair
AYR67_RS03110	COG0840	transmembrane signaling receptor activity
AYR67_RS03130	COG5510	response to toxic substance
AYR67_RS03140	COG2832	Protein of unknown function (DUF454)
AYR67_RS03145	COG1376	ErfK ybiS ycfS ynhG family protein
AYR67_RS03185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AYR67_RS03195	COG1289	transmembrane transporter activity
AYR67_RS03200	COG2814	Major facilitator Superfamily
AYR67_RS03215	COG1115	amino acid carrier protein
AYR67_RS03220	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR67_RS03225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR67_RS03230	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AYR67_RS03270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR67_RS03280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYR67_RS03285	COG1077	Cell shape determining protein MreB Mrl
AYR67_RS03290	COG1792	Involved in formation and maintenance of cell shape
AYR67_RS03295	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AYR67_RS03300	COG0424	maF-like protein
AYR67_RS03305	COG1530	ribonuclease E activity
AYR67_RS03315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR67_RS03325	COG0560	Phosphoserine phosphatase
AYR67_RS03335	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR67_RS03360	COG2207	Transcriptional regulator
AYR67_RS03380	COG1113	amino acid transport
AYR67_RS03385	COG2828	Protein conserved in bacteria
AYR67_RS03390	COG0142	geranyltranstransferase activity
AYR67_RS03395	COG2315	Protein conserved in bacteria
AYR67_RS03410	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYR67_RS03430	COG2194	sulfuric ester hydrolase activity
AYR67_RS03435	COG0745	RESPONSE REGULATOR receiver
AYR67_RS03440	COG0642	Histidine kinase
AYR67_RS03450	COG0004	ammonium transporteR
AYR67_RS03455	COG0583	DNA-binding transcription factor activity
AYR67_RS03475	COG0525	valine-tRNA ligase activity
AYR67_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS03495	COG0393	Putative heavy-metal-binding
AYR67_RS03500	COG0393	Putative heavy-metal-binding
AYR67_RS03505	COG1538	Outer membrane efflux protein
AYR67_RS03515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS03520	COG0671	phosphoesterase, PA-phosphatase related
AYR67_RS03550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AYR67_RS03565	COG1648	precorrin-2 dehydrogenase activity
AYR67_RS03565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYR67_RS03570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYR67_RS03575	COG1733	regulation of RNA biosynthetic process
AYR67_RS03585	COG0531	amino acid
AYR67_RS03600	COG0321	lipoyl(octanoyl) transferase activity
AYR67_RS03605	COG2921	Belongs to the UPF0250 family
AYR67_RS03645	COG2009	succinate dehydrogenase
AYR67_RS03650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AYR67_RS03655	COG1053	succinate dehydrogenase
AYR67_RS03660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYR67_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR67_RS03695	COG2354	Protein conserved in bacteria
AYR67_RS03700	COG2321	neutral zinc metallopeptidase
AYR67_RS03720	COG2843	Capsule synthesis protein
AYR67_RS03735	COG0589	response to stress
AYR67_RS03755	COG0505	Belongs to the CarA family
AYR67_RS03780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR67_RS03785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYR67_RS03835	COG0477	Major facilitator Superfamily
AYR67_RS03840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYR67_RS03855	COG1597	lipid kinase activity
AYR67_RS03860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR67_RS03890	COG0584	glycerophosphoryl diester phosphodiesterase
AYR67_RS03910	COG0741	lytic transglycosylase activity
AYR67_RS03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYR67_RS03945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR67_RS03970	COG0778	Nitroreductase
AYR67_RS03985	COG1929	Belongs to the glycerate kinase type-1 family
AYR67_RS03990	COG0243	molybdopterin cofactor binding
AYR67_RS03995	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYR67_RS04000	COG3339	Conserved Protein
AYR67_RS04010	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AYR67_RS04025	COG1113	amino acid transport
AYR67_RS04035	COG0019	diaminopimelate decarboxylase activity
AYR67_RS04045	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS04050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYR67_RS04080	COG0463	Glycosyl transferase, family 2
AYR67_RS04100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS04130	COG4591	ABC-type transport system involved in lipoprotein release permease component
AYR67_RS04135	COG1136	(ABC) transporter
AYR67_RS04140	COG2333	competence protein COMEC
AYR67_RS04140	COG0658	competence protein
AYR67_RS04150	COG0616	signal peptide processing
AYR67_RS04150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYR67_RS04155	COG0596	Alpha beta hydrolase
AYR67_RS04160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYR67_RS04170	COG0628	permease
AYR67_RS04205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR67_RS04225	COG0823	Involved in the tonB-independent uptake of proteins
AYR67_RS04245	COG0824	Thioesterase
AYR67_RS04250	COG1473	amidohydrolase
AYR67_RS04270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYR67_RS04270	COG0047	phosphoribosylformylglycinamidine synthase activity
AYR67_RS04275	COG2814	Major facilitator Superfamily
AYR67_RS04290	COG1024	Enoyl-CoA hydratase
AYR67_RS04295	COG1051	belongs to the nudix hydrolase family
AYR67_RS04295	COG1056	cytidyltransferase-related domain
AYR67_RS04305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYR67_RS04320	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AYR67_RS04335	COG4625	pathogenesis
AYR67_RS04340	COG0583	DNA-binding transcription factor activity
AYR67_RS04345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AYR67_RS04350	COG4208	sulfate ABC transporter
AYR67_RS04355	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AYR67_RS04365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AYR67_RS04370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYR67_RS04375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYR67_RS04395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR67_RS04410	COG0681	Belongs to the peptidase S26 family
AYR67_RS04425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYR67_RS04435	COG1381	Involved in DNA repair and RecF pathway recombination
AYR67_RS04440	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AYR67_RS04450	COG4221	oxidoreductase activity
AYR67_RS04475	COG0436	Aminotransferase
AYR67_RS04495	COG0556	nucleotide-excision repair
AYR67_RS04550	COG2070	2-Nitropropane dioxygenase
AYR67_RS04580	COG1215	transferase activity, transferring glycosyl groups
AYR67_RS04595	COG0415	Belongs to the DNA photolyase family
AYR67_RS04605	COG1252	NADH dehydrogenase
AYR67_RS04610	COG1686	Belongs to the peptidase S11 family
AYR67_RS04625	COG1187	pseudouridine synthase activity
AYR67_RS04645	COG0477	Major facilitator Superfamily
AYR67_RS04650	COG0583	DNA-binding transcription factor activity
AYR67_RS04655	COG1823	symporter activity
AYR67_RS04665	COG0612	Peptidase, M16
AYR67_RS04690	COG0352	thiamine-phosphate diphosphorylase activity
AYR67_RS04725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR67_RS04740	COG1309	transcriptional regulator
AYR67_RS04750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYR67_RS04755	COG0076	glutamate decarboxylase activity
AYR67_RS04765	COG1522	sequence-specific DNA binding
AYR67_RS04770	COG3961	Belongs to the TPP enzyme family
AYR67_RS04775	COG1113	amino acid transport
AYR67_RS04780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYR67_RS04785	COG0573	inorganic phosphate transmembrane transporter activity
AYR67_RS04795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYR67_RS04800	COG0616	signal peptide processing
AYR67_RS04810	COG3328	transposase activity
AYR67_RS04840	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AYR67_RS04845	COG1686	Belongs to the peptidase S11 family
AYR67_RS04870	COG0583	DNA-binding transcription factor activity
AYR67_RS04875	COG1067	ATP-dependent peptidase activity
AYR67_RS04920	COG1966	Carbon starvation protein
AYR67_RS04925	COG2879	small protein
AYR67_RS04955	COG2508	Transcriptional regulator
AYR67_RS04955	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AYR67_RS04975	COG1113	amino acid transport
AYR67_RS04980	COG0583	DNA-binding transcription factor activity
AYR67_RS04985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR67_RS04990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYR67_RS05000	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS05005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR67_RS05010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYR67_RS05010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR67_RS05045	COG2814	Major facilitator Superfamily
AYR67_RS05050	COG4948	Mandelate Racemase Muconate Lactonizing
AYR67_RS05060	COG1309	transcriptional regulator
AYR67_RS05075	COG1741	Belongs to the pirin family
AYR67_RS05085	COG2964	Protein conserved in bacteria
AYR67_RS05100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR67_RS05105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR67_RS05110	COG4605	iron ion homeostasis
AYR67_RS05115	COG4604	ABC transporter, ATP-binding protein
AYR67_RS05120	COG4607	ABC-type enterochelin transport system periplasmic component
AYR67_RS05125	COG4774	siderophore transport
AYR67_RS05135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYR67_RS05140	COG1021	2,3-dihydroxybenzoate-AMP ligase
AYR67_RS05145	COG3433	isochorismatase activity
AYR67_RS05145	COG1535	isochorismatase
AYR67_RS05160	COG1132	(ABC) transporter
AYR67_RS05165	COG1132	(ABC) transporter
AYR67_RS05170	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AYR67_RS05180	COG1169	isochorismate synthase
AYR67_RS05195	COG3739	integral membrane protein
AYR67_RS05225	COG0302	gtp cyclohydrolase
AYR67_RS05235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYR67_RS05265	COG0308	aminopeptidase N
AYR67_RS05270	COG0512	Glutamine amidotransferase of anthranilate synthase
AYR67_RS05285	COG0174	glutamine synthetase
AYR67_RS05295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYR67_RS05330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYR67_RS05335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYR67_RS05340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYR67_RS05360	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYR67_RS05365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYR67_RS05370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYR67_RS05385	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS05390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR67_RS05395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR67_RS05410	COG2223	nitrite transmembrane transporter activity
AYR67_RS05420	COG0024	Methionine aminopeptidase
AYR67_RS05425	COG0052	Belongs to the universal ribosomal protein uS2 family
AYR67_RS05440	COG2207	Transcriptional regulator
AYR67_RS05465	COG2951	lytic endotransglycosylase activity
AYR67_RS05470	COG0772	Belongs to the SEDS family
AYR67_RS05485	COG0842	Transport permease protein
AYR67_RS05490	COG1131	(ABC) transporter
AYR67_RS05535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS05550	COG4215	(ABC) transporter
AYR67_RS05555	COG4160	amino acid transport
AYR67_RS05560	COG4598	ABC transporter
AYR67_RS05570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR67_RS05575	COG0826	peptidase U32
AYR67_RS05580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR67_RS05595	COG1720	tRNA m6t6A37 methyltransferase activity
AYR67_RS05605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AYR67_RS05620	COG0642	Histidine kinase
AYR67_RS05630	COG0494	nUDIX hydrolase
AYR67_RS05640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYR67_RS05645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYR67_RS05650	COG3139	Protein of unknown function (DUF1315)
AYR67_RS05655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYR67_RS05660	COG1301	dicarboxylic acid transport
AYR67_RS05665	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS05670	COG2819	hydrolase of the alpha beta superfamily
AYR67_RS05680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYR67_RS05690	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYR67_RS05695	COG1234	tRNA 3'-trailer cleavage
AYR67_RS05725	COG2363	Small membrane protein
AYR67_RS05745	COG0513	Belongs to the DEAD box helicase family
AYR67_RS05755	COG0778	Nitroreductase
AYR67_RS05785	COG1286	toxin biosynthetic process
AYR67_RS05810	COG4783	chaperone-mediated protein folding
AYR67_RS05815	COG1610	YqeY-like protein
AYR67_RS05915	COG3111	PFAM Bacterial OB fold (BOF) protein
AYR67_RS05940	COG3243	poly(R)-hydroxyalkanoic acid synthase
AYR67_RS05945	COG0786	glutamate:sodium symporter activity
AYR67_RS05955	COG2186	Transcriptional regulator
AYR67_RS06005	COG0477	Major facilitator Superfamily
AYR67_RS06030	COG2985	domain, Protein
AYR67_RS06040	COG2995	paraquat-inducible protein a
AYR67_RS06045	COG3008	intermembrane lipid transfer
AYR67_RS06045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYR67_RS06055	COG1794	racemase activity, acting on amino acids and derivatives
AYR67_RS06075	COG1301	dicarboxylic acid transport
AYR67_RS06085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR67_RS06090	COG2011	ABC-type metal ion transport system permease component
AYR67_RS06095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR67_RS06100	COG1464	Belongs to the NlpA lipoprotein family
AYR67_RS06105	COG0151	Belongs to the GarS family
AYR67_RS06110	COG0138	bifunctional purine biosynthesis protein purh
AYR67_RS06115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AYR67_RS06145	COG2308	Evidence 4 Homologs of previously reported genes of
AYR67_RS06155	COG1305	Transglutaminase-like
AYR67_RS06165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYR67_RS06170	COG0305	Participates in initiation and elongation during chromosome replication
AYR67_RS06195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AYR67_RS06205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYR67_RS06210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYR67_RS06235	COG0726	polysaccharide deacetylase
AYR67_RS06235	COG1649	PFAM Uncharacterised BCR, COG1649
AYR67_RS06240	COG1215	transferase activity, transferring glycosyl groups
AYR67_RS06245	COG3658	cytochrome
AYR67_RS06255	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR67_RS06270	COG0583	DNA-binding transcription factor activity
AYR67_RS06290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR67_RS06295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR67_RS06310	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS06315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR67_RS06320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR67_RS06345	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYR67_RS06350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AYR67_RS06360	COG2205	protein histidine kinase activity
AYR67_RS06365	COG0745	RESPONSE REGULATOR receiver
AYR67_RS06370	COG0174	glutamine synthetase
AYR67_RS06390	COG0729	surface antigen
AYR67_RS06415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR67_RS06420	COG2814	Major facilitator Superfamily
AYR67_RS06435	COG0583	DNA-binding transcription factor activity
AYR67_RS06450	COG1187	pseudouridine synthase activity
AYR67_RS06470	COG0802	atpase or kinase
AYR67_RS06475	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYR67_RS06485	COG1923	regulation of RNA biosynthetic process
AYR67_RS06490	COG0697	spore germination
AYR67_RS06505	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR67_RS06515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR67_RS06520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR67_RS06520	COG0519	Catalyzes the synthesis of GMP from XMP
AYR67_RS06525	COG4302	ethanolamine ammonia-lyase activity
AYR67_RS06530	COG4303	Ethanolamine ammonia lyase large subunit
AYR67_RS06535	COG0531	amino acid
AYR67_RS06555	COG1454	alcohol dehydrogenase
AYR67_RS06560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR67_RS06570	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AYR67_RS06590	COG0308	aminopeptidase N
AYR67_RS06600	COG4221	oxidoreductase activity
AYR67_RS06625	COG1605	Chorismate mutase
AYR67_RS06640	COG1309	transcriptional regulator
AYR67_RS06650	COG0668	transmembrane transport
AYR67_RS06690	COG4773	Receptor
AYR67_RS06710	COG0488	(ABC) transporter
AYR67_RS06715	COG0589	response to stress
AYR67_RS06735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYR67_RS06745	COG3135	benzoate transporter
AYR67_RS06750	COG1522	sequence-specific DNA binding
AYR67_RS06760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYR67_RS06765	COG0583	DNA-binding transcription factor activity
AYR67_RS06775	COG0183	Belongs to the thiolase family
AYR67_RS06785	COG2030	dehydratase
AYR67_RS06790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR67_RS06805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYR67_RS06815	COG0824	Thioesterase
AYR67_RS06820	COG1454	alcohol dehydrogenase
AYR67_RS06830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYR67_RS06850	COG0069	glutamate synthase activity
AYR67_RS07035	COG3755	Protein conserved in bacteria
AYR67_RS07185	COG2026	Addiction module toxin, RelE StbE family
AYR67_RS07225	COG0592	DNA-directed DNA polymerase activity
AYR67_RS07370	COG2814	Major facilitator Superfamily
AYR67_RS07385	COG0511	ligase activity, forming carbon-carbon bonds
AYR67_RS07400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR67_RS07400	COG1116	anion transmembrane transporter activity
AYR67_RS07405	COG0745	RESPONSE REGULATOR receiver
AYR67_RS07415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR67_RS07415	COG2146	nitrite reductase [NAD(P)H] activity
AYR67_RS07420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR67_RS07425	COG0243	molybdopterin cofactor binding
AYR67_RS07435	COG0243	molybdopterin cofactor binding
AYR67_RS07440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AYR67_RS07455	COG0315	cyclic pyranopterin monophosphate synthase activity
AYR67_RS07455	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYR67_RS07460	COG0303	'Molybdopterin
AYR67_RS07470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR67_RS07475	COG0697	spore germination
AYR67_RS07495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AYR67_RS07500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR67_RS07575	COG1061	Type III restriction enzyme res subunit
AYR67_RS07595	COG0659	secondary active sulfate transmembrane transporter activity
AYR67_RS07600	COG0589	response to stress
AYR67_RS07685	COG2204	response regulator
AYR67_RS07690	COG3852	Histidine kinase
AYR67_RS07710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYR67_RS07715	COG0575	Belongs to the CDS family
AYR67_RS07750	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR67_RS07765	COG2137	regulation of response to DNA damage stimulus
AYR67_RS07775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYR67_RS07780	COG1011	Hydrolase
AYR67_RS07805	COG1522	sequence-specific DNA binding
AYR67_RS07815	COG1113	amino acid transport
AYR67_RS07830	COG0659	secondary active sulfate transmembrane transporter activity
AYR67_RS07835	COG2135	peptidase activity
AYR67_RS07850	COG3300	MHYT domain
AYR67_RS07850	COG5001	Diguanylate cyclase
AYR67_RS07870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR67_RS07870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYR67_RS07870	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AYR67_RS07875	COG1105	Belongs to the carbohydrate kinase PfkB family
AYR67_RS07880	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR67_RS07880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYR67_RS07910	COG0024	Methionine aminopeptidase
AYR67_RS07915	COG0583	DNA-binding transcription factor activity
AYR67_RS07925	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AYR67_RS07930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYR67_RS07935	COG0517	IMP dehydrogenase activity
AYR67_RS07935	COG0516	GMP reductase activity
AYR67_RS07960	COG0552	protein localization to endoplasmic reticulum
AYR67_RS07970	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AYR67_RS07985	COG4890	Cyd operon protein YbgT
AYR67_RS07990	COG1294	oxidase, subunit
AYR67_RS08005	COG1585	Membrane protein implicated in regulation of membrane protease activity
AYR67_RS08015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYR67_RS08020	COG4774	siderophore transport
AYR67_RS08035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYR67_RS08040	COG0569	domain protein
AYR67_RS08045	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYR67_RS08075	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYR67_RS08080	COG0542	response to heat
AYR67_RS08105	COG1902	pentaerythritol trinitrate reductase activity
AYR67_RS08105	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR67_RS08150	COG2323	membrane
AYR67_RS08155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AYR67_RS08165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR67_RS08170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR67_RS08175	COG0183	Belongs to the thiolase family
AYR67_RS08180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYR67_RS08185	COG0596	Alpha beta hydrolase
AYR67_RS08190	COG2271	Major facilitator Superfamily
AYR67_RS08195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR67_RS08200	COG3485	protocatechuate 3,4-dioxygenase
AYR67_RS08205	COG3485	protocatechuate 3,4-dioxygenase
AYR67_RS08210	COG0710	3-dehydroquinate dehydratase activity
AYR67_RS08215	COG3420	alginic acid biosynthetic process
AYR67_RS08220	COG3659	wide pore channel activity
AYR67_RS08225	COG4993	Dehydrogenase
AYR67_RS08235	COG2391	methyltransferase activity
AYR67_RS08250	COG1414	Transcriptional regulator
AYR67_RS08255	COG0583	DNA-binding transcription factor activity
AYR67_RS08260	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS08285	COG2814	Major facilitator Superfamily
AYR67_RS08295	COG0154	amidase activity
AYR67_RS08315	COG4638	Rieske (2fe-2S)
AYR67_RS08325	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS08335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR67_RS08345	COG3733	amine oxidase
AYR67_RS08355	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS08365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR67_RS08370	COG0183	Belongs to the thiolase family
AYR67_RS08375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR67_RS08380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR67_RS08390	COG4829	muconolactone delta-isomerase
AYR67_RS08395	COG4948	Mandelate Racemase Muconate Lactonizing
AYR67_RS08400	COG0583	DNA-binding transcription factor activity
AYR67_RS08410	COG2186	Transcriptional regulator
AYR67_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS08450	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS08460	COG3829	transcription factor binding
AYR67_RS08470	COG3162	membrane
AYR67_RS08485	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS08500	COG0753	catalase activity
AYR67_RS08525	COG1846	Transcriptional regulator
AYR67_RS08530	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR67_RS08530	COG1902	pentaerythritol trinitrate reductase activity
AYR67_RS08540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYR67_RS08570	COG1309	transcriptional regulator
AYR67_RS08580	COG1335	isochorismatase
AYR67_RS08585	COG0583	DNA-binding transcription factor activity
AYR67_RS08595	COG0475	glutathione-regulated potassium exporter activity
AYR67_RS08595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR67_RS08605	COG1473	amidohydrolase
AYR67_RS08615	COG2831	hemolysin activation secretion protein
AYR67_RS08620	COG3210	domain, Protein
AYR67_RS08650	COG2188	Transcriptional regulator
AYR67_RS08670	COG0583	DNA-binding transcription factor activity
AYR67_RS08700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR67_RS08720	COG1566	PFAM secretion protein HlyD family protein
AYR67_RS08735	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS08740	COG0129	dihydroxy-acid dehydratase activity
AYR67_RS08750	COG0583	DNA-binding transcription factor activity
AYR67_RS08755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYR67_RS08765	COG2084	Dehydrogenase
AYR67_RS08770	COG2207	Transcriptional regulator
AYR67_RS08785	COG1064	alcohol dehydrogenase
AYR67_RS08795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYR67_RS08800	COG1120	ATPase activity
AYR67_RS08820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR67_RS08935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AYR67_RS08985	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS09000	COG2207	Transcriptional regulator
AYR67_RS09010	COG2205	protein histidine kinase activity
AYR67_RS09015	COG0745	RESPONSE REGULATOR receiver
AYR67_RS09020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS09025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR67_RS09030	COG1538	Outer membrane efflux protein
AYR67_RS09040	COG2072	flavoprotein involved in K transport
AYR67_RS09060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR67_RS09080	COG3539	Fimbrial protein
AYR67_RS09115	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYR67_RS09125	COG0753	catalase activity
AYR67_RS09140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYR67_RS09200	COG1535	isochorismatase
AYR67_RS09200	COG3433	isochorismatase activity
AYR67_RS09205	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS09210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AYR67_RS09215	COG4149	molybdate abc transporter
AYR67_RS09220	COG0725	ABC transporter, periplasmic molybdate-binding protein
AYR67_RS09230	COG4638	Rieske (2fe-2S)
AYR67_RS09235	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR67_RS09240	COG0543	2 iron, 2 sulfur cluster binding
AYR67_RS09240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR67_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS09280	COG2207	Transcriptional regulator
AYR67_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS09300	COG2610	gluconate transmembrane transporter activity
AYR67_RS09310	COG0583	DNA-binding transcription factor activity
AYR67_RS09320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR67_RS09325	COG2031	fatty acid transporter
AYR67_RS09330	COG0183	Belongs to the thiolase family
AYR67_RS09335	COG0583	DNA-binding transcription factor activity
AYR67_RS09340	COG0583	DNA-binding transcription factor activity
AYR67_RS09355	COG1027	Aspartate ammonia-lyase
AYR67_RS09365	COG0477	Major facilitator Superfamily
AYR67_RS09385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR67_RS09390	COG4521	taurine ABC transporter
AYR67_RS09405	COG2188	Transcriptional regulator
AYR67_RS09415	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYR67_RS09420	COG1733	regulation of RNA biosynthetic process
AYR67_RS09425	COG3708	Transcriptional regulator
AYR67_RS09425	COG2207	Transcriptional regulator
AYR67_RS09440	COG0730	response to heat
AYR67_RS09450	COG3453	Protein conserved in bacteria
AYR67_RS09450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR67_RS09460	COG3781	membrane
AYR67_RS09465	COG1063	alcohol dehydrogenase
AYR67_RS09475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYR67_RS09480	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYR67_RS09485	COG0022	dehydrogenase e1 component
AYR67_RS09490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYR67_RS09495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYR67_RS09510	COG3706	GGDEF domain
AYR67_RS09525	COG0133	tryptophan synthase activity
AYR67_RS09535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYR67_RS09570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYR67_RS09595	COG2226	methyltransferase
AYR67_RS09660	COG0842	Transport permease protein
AYR67_RS09665	COG0842	Transport permease protein
AYR67_RS09670	COG1131	(ABC) transporter
AYR67_RS09685	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYR67_RS09690	COG4773	Receptor
AYR67_RS09710	COG0730	response to heat
AYR67_RS09715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYR67_RS09735	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AYR67_RS09750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR67_RS09790	COG4264	IucA IucC family
AYR67_RS09795	COG4264	IucA IucC family
AYR67_RS09815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYR67_RS09830	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS09835	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS09840	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYR67_RS09845	COG2207	Transcriptional regulator
AYR67_RS09850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR67_RS09855	COG0776	regulation of translation
AYR67_RS09880	COG0822	iron-sulfur transferase activity
AYR67_RS09885	COG0316	Belongs to the HesB IscA family
AYR67_RS09915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYR67_RS09935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYR67_RS09940	COG0702	epimerase
AYR67_RS09975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYR67_RS09985	COG0339	signal peptide processing
AYR67_RS10030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYR67_RS10035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AYR67_RS10065	COG0776	regulation of translation
AYR67_RS10130	COG0084	hydrolase, TatD family'
AYR67_RS10150	COG1663	tetraacyldisaccharide 4'-kinase activity
AYR67_RS10155	COG1132	(ABC) transporter
AYR67_RS10165	COG0811	peptide transport
AYR67_RS10170	COG1475	DNA binding
AYR67_RS10175	COG1192	Involved in chromosome partitioning
AYR67_RS10185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYR67_RS10200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYR67_RS10205	COG0191	fructose-bisphosphate aldolase activity
AYR67_RS10225	COG0424	maF-like protein
AYR67_RS10230	COG2850	peptidyl-arginine hydroxylation
AYR67_RS10240	COG0640	Transcriptional regulator
AYR67_RS10250	COG3619	membrane
AYR67_RS10255	COG3122	Protein conserved in bacteria
AYR67_RS10260	COG1132	(ABC) transporter
AYR67_RS10280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYR67_RS10285	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYR67_RS10295	COG0506	proline dehydrogenase activity
AYR67_RS10295	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR67_RS10295	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYR67_RS10300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYR67_RS10315	COG3698	Phosphodiester glycosidase
AYR67_RS10325	COG2353	YceI-like domain
AYR67_RS10335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYR67_RS10380	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYR67_RS10380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYR67_RS10405	COG3539	Fimbrial protein
AYR67_RS10410	COG3121	Chaperone
AYR67_RS10435	COG0697	spore germination
AYR67_RS10445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR67_RS10455	COG0583	DNA-binding transcription factor activity
AYR67_RS10475	COG1309	transcriptional regulator
AYR67_RS10490	COG1522	sequence-specific DNA binding
AYR67_RS10500	COG1126	abc transporter atp-binding protein
AYR67_RS10505	COG0765	amino acid transport
AYR67_RS10510	COG0765	amino acid transport
AYR67_RS10540	COG1464	Belongs to the NlpA lipoprotein family
AYR67_RS10550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYR67_RS10555	COG2011	ABC-type metal ion transport system permease component
AYR67_RS10560	COG0012	GTP binding
AYR67_RS10585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYR67_RS10625	COG0386	Belongs to the glutathione peroxidase family
AYR67_RS10635	COG0436	Aminotransferase
AYR67_RS10675	COG3634	alkyl hydroperoxide reductase activity
AYR67_RS10690	COG0583	DNA-binding transcription factor activity
AYR67_RS10695	COG0798	PFAM Bile acid sodium symporter
AYR67_RS10700	COG0640	Transcriptional regulator
AYR67_RS10715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AYR67_RS10725	COG0583	DNA-binding transcription factor activity
AYR67_RS10735	COG1953	Uracil, thiamine, allantoin
AYR67_RS10745	COG2175	clavaminate synthase activity
AYR67_RS10750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR67_RS10755	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AYR67_RS10760	COG4521	taurine ABC transporter
AYR67_RS10770	COG0477	Major facilitator Superfamily
AYR67_RS10790	COG1271	oxidase subunit
AYR67_RS10795	COG1294	oxidase, subunit
AYR67_RS10805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYR67_RS10825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AYR67_RS10845	COG3052	prosthetic group binding
AYR67_RS10850	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AYR67_RS10860	COG2814	Major facilitator Superfamily
AYR67_RS10880	COG1346	cytolysis
AYR67_RS10890	COG0583	DNA-binding transcription factor activity
AYR67_RS10895	COG0625	glutathione transferase activity
AYR67_RS10900	COG0625	glutathione transferase activity
AYR67_RS10905	COG0583	DNA-binding transcription factor activity
AYR67_RS10920	COG1045	serine acetyltransferase
AYR67_RS10925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYR67_RS10930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYR67_RS10935	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS10945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR67_RS10950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR67_RS10955	COG1126	abc transporter atp-binding protein
AYR67_RS10960	COG0765	amino acid transport
AYR67_RS10965	COG0765	amino acid transport
AYR67_RS10980	COG2205	protein histidine kinase activity
AYR67_RS10980	COG0784	Response regulator, receiver
AYR67_RS11000	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR67_RS11020	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS11070	COG0583	DNA-binding transcription factor activity
AYR67_RS11090	COG0318	PFAM AMP-dependent synthetase and ligase
AYR67_RS11095	COG1309	transcriptional regulator
AYR67_RS11100	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS11105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYR67_RS11110	COG1024	Enoyl-CoA hydratase
AYR67_RS11115	COG4770	biotin carboxylase activity
AYR67_RS11125	COG0583	DNA-binding transcription factor activity
AYR67_RS11140	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS11150	COG2814	Major facilitator Superfamily
AYR67_RS11160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYR67_RS11165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYR67_RS11170	COG2814	Major facilitator Superfamily
AYR67_RS11175	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS11180	COG1024	Enoyl-CoA hydratase
AYR67_RS11185	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS11190	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR67_RS11195	COG0183	Belongs to the thiolase family
AYR67_RS11205	COG2814	Major facilitator Superfamily
AYR67_RS11215	COG1024	Enoyl-CoA hydratase
AYR67_RS11230	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS11235	COG2814	Major facilitator Superfamily
AYR67_RS11240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYR67_RS11245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYR67_RS11260	COG3842	ATPase activity
AYR67_RS11265	COG1840	ABC-type Fe3 transport system, periplasmic component
AYR67_RS11275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR67_RS11280	COG1414	Transcriptional regulator
AYR67_RS11290	COG0583	DNA-binding transcription factor activity
AYR67_RS11295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYR67_RS11300	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS11310	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYR67_RS11315	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS11320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR67_RS11325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR67_RS11330	COG2267	carboxylic ester hydrolase activity
AYR67_RS11350	COG3038	cytochrome b561
AYR67_RS11355	COG0753	catalase activity
AYR67_RS11390	COG2050	protein possibly involved in aromatic compounds catabolism
AYR67_RS11400	COG3327	negative regulation of DNA-templated transcription, initiation
AYR67_RS11405	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYR67_RS11410	COG0183	Belongs to the thiolase family
AYR67_RS11415	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR67_RS11420	COG1024	Enoyl-CoA hydratase
AYR67_RS11425	COG1024	Enoyl-CoA hydratase
AYR67_RS11430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYR67_RS11435	COG2151	metal-sulfur cluster biosynthetic enzyme
AYR67_RS11440	COG3396	Phenylacetate-CoA oxygenase
AYR67_RS11445	COG3460	Phenylacetate-CoA oxygenase
AYR67_RS11450	COG3396	Phenylacetate-CoA oxygenase
AYR67_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS11455	COG2030	dehydratase
AYR67_RS11460	COG1760	l-serine dehydratase
AYR67_RS11465	COG0531	amino acid
AYR67_RS11470	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS11485	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR67_RS11495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYR67_RS11515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR67_RS11525	COG0789	Transcriptional regulator
AYR67_RS11545	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYR67_RS11560	COG2807	transmembrane transport
AYR67_RS11565	COG0590	tRNA wobble adenosine to inosine editing
AYR67_RS11685	COG1116	anion transmembrane transporter activity
AYR67_RS11690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYR67_RS11700	COG0864	Transcriptional regulator
AYR67_RS11715	COG1733	regulation of RNA biosynthetic process
AYR67_RS11720	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYR67_RS11725	COG0439	Biotin carboxylase
AYR67_RS11740	COG1063	alcohol dehydrogenase
AYR67_RS11750	COG1309	transcriptional regulator
AYR67_RS11775	COG0038	chloride channel
AYR67_RS11780	COG4770	biotin carboxylase activity
AYR67_RS11800	COG1914	H( )-stimulated, divalent metal cation uptake system
AYR67_RS11805	COG0583	DNA-binding transcription factor activity
AYR67_RS11850	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYR67_RS11870	COG2814	Major facilitator Superfamily
AYR67_RS11880	COG1560	Kdo2-lipid A biosynthetic process
AYR67_RS11890	COG5006	permease, DMT superfamily
AYR67_RS11895	COG1522	sequence-specific DNA binding
AYR67_RS11910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AYR67_RS11920	COG4122	O-methyltransferase activity
AYR67_RS11950	COG1538	Outer membrane efflux protein
AYR67_RS11955	COG1137	ATPase activity
AYR67_RS11960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AYR67_RS11970	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYR67_RS11975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYR67_RS11975	COG0517	IMP dehydrogenase activity
AYR67_RS12015	COG2814	Major facilitator Superfamily
AYR67_RS12045	COG1278	Cold shock
AYR67_RS12050	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS12085	COG1570	exodeoxyribonuclease VII activity
AYR67_RS12135	COG0583	DNA-binding transcription factor activity
AYR67_RS12140	COG4638	Rieske (2fe-2S)
AYR67_RS12145	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYR67_RS12150	COG0633	Ferredoxin
AYR67_RS12150	COG0543	2 iron, 2 sulfur cluster binding
AYR67_RS12155	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS12160	COG3135	benzoate transporter
AYR67_RS12165	COG2814	Major facilitator Superfamily
AYR67_RS12180	COG1643	Atp-dependent helicase
AYR67_RS12185	COG0450	alkyl hydroperoxide reductase
AYR67_RS12195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYR67_RS12205	COG3634	alkyl hydroperoxide reductase activity
AYR67_RS12225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYR67_RS12230	COG0625	glutathione transferase activity
AYR67_RS12240	COG2885	chlorophyll binding
AYR67_RS12275	COG0542	response to heat
AYR67_RS12290	COG1765	OsmC-like protein
AYR67_RS12310	COG0667	Aldo Keto reductase
AYR67_RS12325	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYR67_RS12335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYR67_RS12345	COG0527	aspartate kinase activity
AYR67_RS12355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYR67_RS12365	COG3038	cytochrome b561
AYR67_RS12370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYR67_RS12375	COG2252	PERMEase
AYR67_RS12385	COG2072	flavoprotein involved in K transport
AYR67_RS12400	COG1741	Belongs to the pirin family
AYR67_RS12405	COG1309	transcriptional regulator
AYR67_RS12430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AYR67_RS12470	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYR67_RS12470	COG1902	pentaerythritol trinitrate reductase activity
AYR67_RS12480	COG4251	negative regulation of phosphorylation
AYR67_RS12480	COG3706	GGDEF domain
AYR67_RS12480	COG2203	Gaf domain
AYR67_RS12480	COG5001	Diguanylate cyclase
AYR67_RS12490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR67_RS12510	COG4172	Belongs to the ABC transporter superfamily
AYR67_RS12515	COG4239	(ABC) transporter, permease
AYR67_RS12520	COG4174	ABC transporter (Permease)
AYR67_RS12530	COG0741	lytic transglycosylase activity
AYR67_RS12530	COG1388	LysM domain
AYR67_RS12530	COG0741	lytic transglycosylase activity
AYR67_RS12530	COG1388	LysM domain
AYR67_RS12535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYR67_RS12575	COG0583	DNA-binding transcription factor activity
AYR67_RS12580	COG1279	arginine transmembrane transporter activity
AYR67_RS12600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR67_RS12605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR67_RS12610	COG0006	proline dipeptidase activity
AYR67_RS12745	COG4695	Portal protein
AYR67_RS12835	COG0305	Participates in initiation and elongation during chromosome replication
AYR67_RS12855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYR67_RS12910	COG2194	sulfuric ester hydrolase activity
AYR67_RS12955	COG0739	heme binding
AYR67_RS13270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYR67_RS13295	COG3384	dioxygenase
AYR67_RS13305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYR67_RS13310	COG2878	Part of a membrane complex involved in electron transport
AYR67_RS13315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYR67_RS13335	COG0768	penicillin binding
AYR67_RS13340	COG0742	ribosomal rna small subunit methyltransferase
AYR67_RS13355	COG0830	nickel cation binding
AYR67_RS13365	COG0804	urea catabolic process
AYR67_RS13405	COG1253	flavin adenine dinucleotide binding
AYR67_RS13415	COG2851	Citrate transporter
AYR67_RS13470	COG1773	rubredoxin
AYR67_RS13475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYR67_RS13485	COG0583	DNA-binding transcription factor activity
AYR67_RS13510	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AYR67_RS13515	COG4181	ATPase activity
AYR67_RS13560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYR67_RS13580	COG0306	phosphate transporter
AYR67_RS13645	COG0582	viral genome integration into host DNA
AYR67_RS13655	COG0405	Gamma-glutamyltransferase
AYR67_RS13660	COG2814	Major facilitator Superfamily
AYR67_RS13670	COG2050	protein possibly involved in aromatic compounds catabolism
AYR67_RS13685	COG1090	epimerase
AYR67_RS13705	COG0420	3'-5' exonuclease activity
AYR67_RS13730	COG0735	belongs to the Fur family
AYR67_RS13735	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AYR67_RS13760	COG0121	glutamine amidotransferase
AYR67_RS13775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR67_RS13785	COG0210	DNA helicase
AYR67_RS13790	COG2885	chlorophyll binding
AYR67_RS13795	COG0204	Acyl-transferase
AYR67_RS13810	COG2894	cell division
AYR67_RS13830	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS13835	COG1674	ftsk spoiiie
AYR67_RS13835	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYR67_RS13840	COG0492	ferredoxin-NADP+ reductase activity
AYR67_RS13845	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYR67_RS13855	COG0456	acetyltransferase
AYR67_RS13900	COG1981	membrane
AYR67_RS13915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYR67_RS13915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR67_RS13935	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS13945	COG0657	acetylesterase activity
AYR67_RS13955	COG0473	3-isopropylmalate dehydrogenase activity
AYR67_RS13960	COG0583	DNA-binding transcription factor activity
AYR67_RS13980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYR67_RS14005	COG0564	pseudouridine synthase activity
AYR67_RS14015	COG0358	DNA primase activity
AYR67_RS14030	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AYR67_RS14060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYR67_RS14090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYR67_RS14100	COG0352	thiamine-phosphate diphosphorylase activity
AYR67_RS14100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYR67_RS14100	COG0351	phosphomethylpyrimidine kinase
AYR67_RS14105	COG1652	LysM domain
AYR67_RS14130	COG1399	metal-binding, possibly nucleic acid-binding protein
AYR67_RS14135	COG3101	peptidyl-lysine hydroxylation
AYR67_RS14140	COG0009	L-threonylcarbamoyladenylate synthase
AYR67_RS14145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYR67_RS14150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYR67_RS14165	COG4106	trans-aconitate 2-methyltransferase activity
AYR67_RS14180	COG0596	Alpha beta hydrolase
AYR67_RS14180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR67_RS14180	COG2226	methyltransferase
AYR67_RS14185	COG1877	trehalose-phosphatase activity
AYR67_RS14190	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AYR67_RS14195	COG2223	nitrite transmembrane transporter activity
AYR67_RS14215	COG1196	nuclear chromosome segregation
AYR67_RS14225	COG0730	response to heat
AYR67_RS14240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYR67_RS14250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR67_RS14300	COG0489	protein tyrosine kinase activity
AYR67_RS14310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR67_RS14310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR67_RS14340	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYR67_RS14345	COG2081	HI0933 family
AYR67_RS14355	COG0668	transmembrane transport
AYR67_RS14375	COG0583	DNA-binding transcription factor activity
AYR67_RS14395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYR67_RS14400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR67_RS14430	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYR67_RS14470	COG0745	RESPONSE REGULATOR receiver
AYR67_RS14490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYR67_RS14500	COG2205	protein histidine kinase activity
AYR67_RS14570	COG4993	Dehydrogenase
AYR67_RS14590	COG0384	phenazine biosynthesis protein PhzF
AYR67_RS14615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYR67_RS14630	COG0583	DNA-binding transcription factor activity
AYR67_RS14670	COG0583	DNA-binding transcription factor activity
AYR67_RS14685	COG0583	DNA-binding transcription factor activity
AYR67_RS14690	COG1053	succinate dehydrogenase
AYR67_RS14700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYR67_RS14705	COG2814	Major facilitator Superfamily
AYR67_RS14710	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS14715	COG0583	DNA-binding transcription factor activity
AYR67_RS14720	COG1063	alcohol dehydrogenase
AYR67_RS14750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYR67_RS14755	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYR67_RS14760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR67_RS14775	COG3667	copper resistance
AYR67_RS14780	COG2132	Multicopper oxidase
AYR67_RS14790	COG0561	phosphatase activity
AYR67_RS14795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYR67_RS14820	COG1214	PFAM Peptidase M22, glycoprotease
AYR67_RS14875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYR67_RS14885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYR67_RS14890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYR67_RS14895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYR67_RS14955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYR67_RS14965	COG1846	Transcriptional regulator
AYR67_RS14970	COG1764	response to oxidative stress
AYR67_RS15025	COG0037	tRNA processing
AYR67_RS15035	COG0248	Ppx GppA phosphatase
AYR67_RS15060	COG0072	phenylalanine-tRNA ligase activity
AYR67_RS15100	COG1238	metal cluster binding
AYR67_RS15105	COG0625	glutathione transferase activity
AYR67_RS15120	COG0318	PFAM AMP-dependent synthetase and ligase
AYR67_RS15125	COG3028	Belongs to the UPF0307 family
AYR67_RS15130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYR67_RS15150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYR67_RS15155	COG0617	tRNA 3'-terminal CCA addition
AYR67_RS15160	COG1555	photosystem II stabilization
AYR67_RS15165	COG3956	TIGRFAM MazG family protein
AYR67_RS15175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYR67_RS15195	COG2205	protein histidine kinase activity
AYR67_RS15195	COG5002	protein histidine kinase activity
AYR67_RS15195	COG0784	Response regulator, receiver
AYR67_RS15200	COG1024	Enoyl-CoA hydratase
AYR67_RS15205	COG2084	Dehydrogenase
AYR67_RS15210	COG3622	Belongs to the hyi family
AYR67_RS15240	COG0697	spore germination
AYR67_RS15250	COG2814	Major facilitator Superfamily
AYR67_RS15255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYR67_RS15265	COG0583	DNA-binding transcription factor activity
AYR67_RS15270	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYR67_RS15285	COG0084	hydrolase, TatD family'
AYR67_RS15300	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYR67_RS15330	COG0440	acetolactate synthase activity
AYR67_RS15335	COG0028	Belongs to the TPP enzyme family
AYR67_RS15360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYR67_RS15365	COG0577	efflux transmembrane transporter activity
AYR67_RS15365	COG1136	(ABC) transporter
AYR67_RS15370	COG1538	Outer membrane efflux protein
AYR67_RS15385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYR67_RS15390	COG1162	GTPase activity
AYR67_RS15400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AYR67_RS15420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYR67_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS15465	COG2986	histidine ammonia-lyase
AYR67_RS15480	COG0318	PFAM AMP-dependent synthetase and ligase
AYR67_RS15490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYR67_RS15535	COG1426	Protein conserved in bacteria
AYR67_RS15570	COG0793	Belongs to the peptidase S41A family
AYR67_RS15585	COG2267	carboxylic ester hydrolase activity
AYR67_RS15595	COG1012	belongs to the aldehyde dehydrogenase family
AYR67_RS15600	COG3265	gluconokinase activity
AYR67_RS15610	COG0800	Aldolase
AYR67_RS15630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYR67_RS15635	COG0280	phosphate acetyltransferase
AYR67_RS15635	COG0857	belongs to the CobB CobQ family
AYR67_RS15640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR67_RS15640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYR67_RS15660	COG0740	serine-type endopeptidase activity
AYR67_RS15680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYR67_RS15690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYR67_RS15690	COG2813	Specifically methylates the guanine in position
AYR67_RS15790	COG0788	formyltetrahydrofolate deformylase activity
AYR67_RS15815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR67_RS15815	COG4651	solute:proton antiporter activity
AYR67_RS15835	COG0724	RNA recognition motif
AYR67_RS15840	COG0210	DNA helicase
AYR67_RS15865	COG1733	regulation of RNA biosynthetic process
AYR67_RS15875	COG2900	Belongs to the SlyX family
AYR67_RS15880	COG0488	(ABC) transporter
AYR67_RS15885	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS15890	COG1560	Kdo2-lipid A biosynthetic process
AYR67_RS15900	COG1301	dicarboxylic acid transport
AYR67_RS15955	COG0473	3-isopropylmalate dehydrogenase activity
AYR67_RS16020	COG0583	DNA-binding transcription factor activity
AYR67_RS16030	COG0625	glutathione transferase activity
AYR67_RS16035	COG2378	regulation of single-species biofilm formation
AYR67_RS16040	COG0546	phosphoglycolate phosphatase activity
AYR67_RS16050	COG1530	ribonuclease E activity
AYR67_RS16055	COG0318	PFAM AMP-dependent synthetase and ligase
AYR67_RS16070	COG0583	DNA-binding transcription factor activity
AYR67_RS16075	COG4221	oxidoreductase activity
AYR67_RS16080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYR67_RS16090	COG0534	Mate efflux family protein
AYR67_RS16105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYR67_RS16140	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AYR67_RS16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYR67_RS16160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYR67_RS16170	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AYR67_RS16170	COG0644	oxidoreductase
AYR67_RS16175	COG0425	Belongs to the sulfur carrier protein TusA family
AYR67_RS16180	COG4535	Mg2 and Co2 transporter CorC
AYR67_RS16190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYR67_RS16210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYR67_RS16215	COG0475	glutathione-regulated potassium exporter activity
AYR67_RS16215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYR67_RS16220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYR67_RS16230	COG0484	heat shock protein binding
AYR67_RS16235	COG0789	Transcriptional regulator
AYR67_RS16240	COG0598	Magnesium transport protein CorA
AYR67_RS16255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AYR67_RS16260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYR67_RS16265	COG1074	ATP-dependent DNA helicase activity
AYR67_RS16270	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AYR67_RS16290	COG2226	methyltransferase
AYR67_RS16305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYR67_RS16310	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYR67_RS16325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYR67_RS16325	COG2111	Na H antiporter
AYR67_RS16330	COG1006	Multisubunit Na H antiporter MnhC subunit
AYR67_RS16335	COG0651	ATP synthesis coupled electron transport
AYR67_RS16340	COG1863	multisubunit Na H antiporter MnhE subunit
AYR67_RS16345	COG2212	antiporter activity
AYR67_RS16350	COG1320	monovalent cation:proton antiporter activity
AYR67_RS16365	COG0195	Participates in both transcription termination and antitermination
AYR67_RS16415	COG0237	dephospho-CoA kinase activity
AYR67_RS16425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYR67_RS16440	COG0497	DNA recombination
AYR67_RS16450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYR67_RS16480	COG2169	Transcriptional regulator
AYR67_RS16480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYR67_RS16485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYR67_RS16550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYR67_RS16565	COG0326	Molecular chaperone. Has ATPase activity
AYR67_RS16580	COG2056	Na+-H+ antiporter family
AYR67_RS16585	COG0596	Alpha beta hydrolase
AYR67_RS16680	COG0546	phosphoglycolate phosphatase activity
AYR67_RS16685	COG1716	ATPase activity
AYR67_RS16730	COG0181	hydroxymethylbilane synthase activity
AYR67_RS16740	COG3275	phosphorelay sensor kinase activity
AYR67_RS16760	COG1538	Outer membrane efflux protein
AYR67_RS16765	COG0697	spore germination
AYR67_RS16790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYR67_RS16795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AYR67_RS16800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYR67_RS16805	COG0772	Belongs to the SEDS family
AYR67_RS16830	COG4974	Belongs to the 'phage' integrase family
AYR67_RS16835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR67_RS16845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYR67_RS16855	COG2197	response regulator
AYR67_RS16870	COG0793	Belongs to the peptidase S41A family
AYR67_RS16875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYR67_RS16880	COG0795	lipopolysaccharide-transporting ATPase activity
AYR67_RS16920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR67_RS16920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYR67_RS16930	COG0004	ammonium transporteR
AYR67_RS16935	COG0347	Belongs to the P(II) protein family
AYR67_RS16945	COG0606	chelatase, subunit chli
AYR67_RS17015	COG1061	Type III restriction enzyme res subunit
AYR67_RS17035	COG0659	secondary active sulfate transmembrane transporter activity
AYR67_RS17040	COG0589	response to stress
AYR67_RS17080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR67_RS17130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYR67_RS17180	COG1061	Type III restriction enzyme res subunit
AYR67_RS17200	COG0659	secondary active sulfate transmembrane transporter activity
AYR67_RS17205	COG0589	response to stress
AYR67_RS17235	COG0606	chelatase, subunit chli
AYR67_RS17250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYR67_RS17265	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYR67_RS17280	COG0318	PFAM AMP-dependent synthetase and ligase
AYR67_RS17290	COG0477	Major facilitator Superfamily
AYR67_RS17295	COG2860	membrane
AYR67_RS17305	COG1253	flavin adenine dinucleotide binding
AYR67_RS17325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYR67_RS17360	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYR67_RS17370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AYR67_RS17405	COG1309	transcriptional regulator
AYR67_RS17440	COG0758	DNA mediated transformation
AYR67_RS17450	COG0697	spore germination
AYR67_RS17455	COG1309	transcriptional regulator
AYR67_RS17470	COG0386	Belongs to the glutathione peroxidase family
AYR67_RS17540	COG1121	(ABC) transporter
AYR67_RS17545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYR67_RS17550	COG1280	lysine exporter protein (LysE YggA)
AYR67_RS17555	COG2837	iron assimilation
AYR67_RS17560	COG0281	malic enzyme
AYR67_RS17610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYR67_RS17610	COG0519	Catalyzes the synthesis of GMP from XMP
AYR67_RS17615	COG4399	Belongs to the UPF0754 family
AYR67_RS17620	COG2259	Doxx family
AYR67_RS17625	COG0586	Pfam SNARE associated Golgi protein
AYR67_RS17640	COG1192	Involved in chromosome partitioning
AYR67_RS17650	COG0271	Belongs to the BolA IbaG family
AYR67_RS17675	COG3916	Acyl-homoserine-lactone synthase
AYR67_RS17680	COG0477	Major facilitator Superfamily
AYR67_RS17685	COG1024	Enoyl-CoA hydratase
AYR67_RS17690	COG1024	Enoyl-CoA hydratase
AYR67_RS17695	COG1960	acyl-CoA dehydrogenase activity
AYR67_RS17700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYR67_RS17720	COG1113	amino acid transport
AYR67_RS17725	COG1113	amino acid transport
AYR67_RS17730	COG0251	oxidation-reduction process
AYR67_RS17770	COG0564	pseudouridine synthase activity
AYR67_RS17810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYR67_RS17825	COG1802	Transcriptional regulator
AYR67_RS17830	COG1448	Aminotransferase
AYR67_RS17835	COG0277	FAD linked oxidase domain protein
AYR67_RS17845	COG2186	Transcriptional regulator
AYR67_RS17855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYR67_RS17860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYR67_RS17875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYR67_RS17880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYR67_RS17885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYR67_RS17930	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS17935	COG1083	cytidylyl-transferase
AYR67_RS17940	COG0673	inositol 2-dehydrogenase activity
AYR67_RS17945	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYR67_RS17950	COG1045	serine acetyltransferase
AYR67_RS17955	COG2089	acid synthase
AYR67_RS17960	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AYR67_RS17965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYR67_RS17975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYR67_RS17980	COG1596	polysaccharide export
AYR67_RS18005	COG0728	peptidoglycan biosynthetic process
AYR67_RS18010	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYR67_RS18065	COG0546	phosphoglycolate phosphatase activity
AYR67_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
AYR67_RS18090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR67_RS18095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYR67_RS18100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYR67_RS18105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYR67_RS18110	COG1116	anion transmembrane transporter activity
AYR67_RS18115	COG1309	transcriptional regulator
AYR67_RS18120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYR67_RS18130	COG0196	riboflavin kinase activity
AYR67_RS18135	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYR67_RS18145	COG1047	Peptidyl-prolyl cis-trans
AYR67_RS18185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYR67_RS18190	COG0657	acetylesterase activity
AYR67_RS18215	COG0583	DNA-binding transcription factor activity
AYR67_RS18245	COG2951	lytic endotransglycosylase activity
AYR67_RS18250	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYR67_RS18270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYR67_RS18280	COG3328	transposase activity
AYR67_RS18285	COG0671	phosphoesterase, PA-phosphatase related
AYR67_RS18290	COG0861	Integral membrane protein TerC family
AYR67_RS18300	COG0754	glutathionylspermidine amidase activity
AYR67_RS18310	COG0402	S-adenosylhomocysteine deaminase activity
AYR67_RS18330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYR67_RS18335	COG1230	cation diffusion facilitator family transporter
AYR67_RS18350	COG0706	membrane insertase activity