locus-tag	class	description
A4U85_RS00010	COG0592	DNA-directed DNA polymerase activity
A4U85_RS00020	COG0187	DNA topoisomerase II activity
A4U85_RS00030	COG0586	Pfam SNARE associated Golgi protein
A4U85_RS00035	COG0488	(ABC) transporter
A4U85_RS00060	COG0596	Alpha beta hydrolase
A4U85_RS00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A4U85_RS00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4U85_RS00105	COG0625	glutathione transferase activity
A4U85_RS00115	COG0733	neurotransmitter:sodium symporter activity
A4U85_RS00150	COG0583	DNA-binding transcription factor activity
A4U85_RS00155	COG2233	PERMEase
A4U85_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS00205	COG2814	Major facilitator Superfamily
A4U85_RS00210	COG0656	L-ascorbic acid biosynthetic process
A4U85_RS00215	COG0583	DNA-binding transcription factor activity
A4U85_RS00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U85_RS00230	COG1064	alcohol dehydrogenase
A4U85_RS00235	COG2818	Glycosylase
A4U85_RS00250	COG1194	a g-specific adenine glycosylase
A4U85_RS00270	COG2983	Belongs to the UPF0260 family
A4U85_RS00275	COG2133	pyrroloquinoline quinone binding
A4U85_RS00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4U85_RS00285	COG2116	formate transmembrane transporter activity
A4U85_RS00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U85_RS00310	COG1335	isochorismatase
A4U85_RS00315	COG0385	Bile acid
A4U85_RS00325	COG1683	Conserved Protein
A4U85_RS00345	COG0625	glutathione transferase activity
A4U85_RS00355	COG1113	amino acid transport
A4U85_RS00365	COG0523	cobalamin synthesis protein
A4U85_RS00375	COG2188	Transcriptional regulator
A4U85_RS00405	COG0010	Belongs to the arginase family
A4U85_RS00415	COG0546	phosphoglycolate phosphatase activity
A4U85_RS00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4U85_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4U85_RS00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4U85_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4U85_RS00490	COG0753	catalase activity
A4U85_RS00540	COG0534	Mate efflux family protein
A4U85_RS00545	COG0436	Aminotransferase
A4U85_RS00550	COG2733	membrane
A4U85_RS00565	COG2918	glutathione biosynthetic process
A4U85_RS00585	COG3179	chitinase
A4U85_RS00600	COG3150	esterase
A4U85_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A4U85_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U85_RS00635	COG2233	PERMEase
A4U85_RS00640	COG2351	hydroxyisourate hydrolase activity
A4U85_RS00675	COG3706	GGDEF domain
A4U85_RS00690	COG1393	Belongs to the ArsC family
A4U85_RS00695	COG0708	Exodeoxyribonuclease III
A4U85_RS00715	COG0189	ligase activity
A4U85_RS00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4U85_RS00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4U85_RS00760	COG4942	peptidase
A4U85_RS00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U85_RS00780	COG2119	membrane
A4U85_RS00785	COG4774	siderophore transport
A4U85_RS00790	COG0426	domain, Protein
A4U85_RS00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U85_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4U85_RS00835	COG1902	pentaerythritol trinitrate reductase activity
A4U85_RS00840	COG1519	Transferase
A4U85_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U85_RS00850	COG0668	transmembrane transport
A4U85_RS00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4U85_RS00865	COG1335	isochorismatase
A4U85_RS00870	COG1522	sequence-specific DNA binding
A4U85_RS00895	COG2198	Histidine kinase
A4U85_RS00895	COG2205	protein histidine kinase activity
A4U85_RS00895	COG0784	Response regulator, receiver
A4U85_RS00900	COG3162	membrane
A4U85_RS00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4U85_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4U85_RS00930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4U85_RS00935	COG1309	transcriptional regulator
A4U85_RS00955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4U85_RS00955	COG0352	thiamine-phosphate diphosphorylase activity
A4U85_RS00955	COG0351	phosphomethylpyrimidine kinase
A4U85_RS00965	COG2814	Major facilitator Superfamily
A4U85_RS01015	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4U85_RS01025	COG1113	amino acid transport
A4U85_RS01035	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U85_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS01050	COG1335	isochorismatase
A4U85_RS01080	COG2814	Major facilitator Superfamily
A4U85_RS01085	COG0583	DNA-binding transcription factor activity
A4U85_RS01105	COG0667	Aldo Keto reductase
A4U85_RS01140	COG1733	regulation of RNA biosynthetic process
A4U85_RS01150	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS01220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4U85_RS01260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4U85_RS01290	COG0427	acetyl-CoA hydrolase
A4U85_RS01310	COG0659	secondary active sulfate transmembrane transporter activity
A4U85_RS01315	COG4221	oxidoreductase activity
A4U85_RS01320	COG2873	o-acetylhomoserine
A4U85_RS01325	COG0488	(ABC) transporter
A4U85_RS01390	COG0833	amino acid
A4U85_RS01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4U85_RS01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4U85_RS01455	COG2226	methyltransferase
A4U85_RS01505	COG0070	glutamate synthase
A4U85_RS01505	COG0069	glutamate synthase activity
A4U85_RS01505	COG0067	glutamate synthase
A4U85_RS01510	COG0493	'glutamate synthase
A4U85_RS01520	COG1704	LemA family
A4U85_RS01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4U85_RS01545	COG3307	-O-antigen
A4U85_RS01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U85_RS01575	COG0194	GDP metabolic process
A4U85_RS01625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4U85_RS01645	COG5380	lipid catabolic process
A4U85_RS01650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4U85_RS01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4U85_RS01680	COG0277	FAD linked oxidase domain protein
A4U85_RS01690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4U85_RS01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS01710	COG1289	transmembrane transporter activity
A4U85_RS01720	COG0628	permease
A4U85_RS01725	COG1192	Involved in chromosome partitioning
A4U85_RS01755	COG0833	amino acid
A4U85_RS01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U85_RS01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4U85_RS01775	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS01815	COG0583	DNA-binding transcription factor activity
A4U85_RS01855	COG0517	IMP dehydrogenase activity
A4U85_RS01860	COG1983	PspC domain protein
A4U85_RS01870	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS01885	COG0408	coproporphyrinogen oxidase activity
A4U85_RS01905	COG0513	Belongs to the DEAD box helicase family
A4U85_RS01910	COG1127	ABC transporter
A4U85_RS01915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4U85_RS01925	COG2854	intermembrane phospholipid transfer
A4U85_RS01935	COG0598	Magnesium transport protein CorA
A4U85_RS01945	COG0494	nUDIX hydrolase
A4U85_RS01950	COG1040	competence protein
A4U85_RS01955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4U85_RS01975	COG1946	Acyl-CoA thioesterase
A4U85_RS01980	COG1301	dicarboxylic acid transport
A4U85_RS01995	COG1959	2 iron, 2 sulfur cluster binding
A4U85_RS02000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U85_RS02000	COG1017	nitric oxide dioxygenase activity
A4U85_RS02005	COG0433	COG0433 Predicted ATPase
A4U85_RS02010	COG0626	cystathionine gamma-synthase activity
A4U85_RS02165	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A4U85_RS02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A4U85_RS02205	COG0339	signal peptide processing
A4U85_RS02210	COG0557	exoribonuclease II activity
A4U85_RS02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4U85_RS02260	COG2169	Transcriptional regulator
A4U85_RS02265	COG0697	spore germination
A4U85_RS02270	COG1295	ribonuclease BN
A4U85_RS02305	COG1702	phosphate starvation-inducible protein PhoH
A4U85_RS02315	COG0741	lytic transglycosylase activity
A4U85_RS02315	COG1196	nuclear chromosome segregation
A4U85_RS02315	COG0739	heme binding
A4U85_RS02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A4U85_RS02350	COG1183	phosphatidylcholine synthase activity
A4U85_RS02400	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS02405	COG1309	transcriptional regulator
A4U85_RS02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4U85_RS02425	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS02445	COG2969	positive regulation of protein catabolic process
A4U85_RS02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4U85_RS02465	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4U85_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4U85_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4U85_RS02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4U85_RS02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U85_RS02510	COG1408	metallophosphoesterase
A4U85_RS02520	COG2199	diguanylate cyclase activity
A4U85_RS02580	COG1607	acyl-coa hydrolase
A4U85_RS02610	COG2350	Protein conserved in bacteria
A4U85_RS02620	COG0613	PHP domain protein
A4U85_RS02625	COG3781	membrane
A4U85_RS02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4U85_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4U85_RS02650	COG1862	Preprotein translocase
A4U85_RS02685	COG2205	protein histidine kinase activity
A4U85_RS02690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4U85_RS02710	COG0726	polysaccharide deacetylase
A4U85_RS02715	COG0463	Glycosyl transferase, family 2
A4U85_RS02720	COG0438	transferase activity, transferring glycosyl groups
A4U85_RS02785	COG0625	glutathione transferase activity
A4U85_RS02790	COG0583	DNA-binding transcription factor activity
A4U85_RS02795	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS02800	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS02810	COG2205	protein histidine kinase activity
A4U85_RS02815	COG0745	RESPONSE REGULATOR receiver
A4U85_RS02820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A4U85_RS02840	COG2096	Adenosyltransferase
A4U85_RS02845	COG4206	TonB-dependent receptor
A4U85_RS02890	COG0285	dihydrofolate synthase activity
A4U85_RS02910	COG0450	alkyl hydroperoxide reductase
A4U85_RS02925	COG0477	Major facilitator Superfamily
A4U85_RS02930	COG1272	protein, Hemolysin III
A4U85_RS02960	COG0183	Belongs to the thiolase family
A4U85_RS02965	COG2207	Transcriptional regulator
A4U85_RS02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U85_RS03005	COG0183	Belongs to the thiolase family
A4U85_RS03015	COG2885	chlorophyll binding
A4U85_RS03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A4U85_RS03020	COG1690	Belongs to the RtcB family
A4U85_RS03025	COG0833	amino acid
A4U85_RS03035	COG2233	PERMEase
A4U85_RS03040	COG1217	gtp-binding protein TYPA
A4U85_RS03065	COG2094	Belongs to the DNA glycosylase MPG family
A4U85_RS03070	COG4772	TonB-dependent receptor
A4U85_RS03075	COG1902	pentaerythritol trinitrate reductase activity
A4U85_RS03080	COG0679	Auxin Efflux Carrier
A4U85_RS03090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U85_RS03095	COG0354	folic acid binding
A4U85_RS03105	COG3189	MarR family transcriptional regulator
A4U85_RS03110	COG2824	Alkylphosphonate utilization operon protein PhnA
A4U85_RS03115	COG3422	double-strand break repair
A4U85_RS03155	COG0840	transmembrane signaling receptor activity
A4U85_RS03175	COG5510	response to toxic substance
A4U85_RS03185	COG2832	Protein of unknown function (DUF454)
A4U85_RS03190	COG1376	ErfK ybiS ycfS ynhG family protein
A4U85_RS03230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4U85_RS03240	COG1289	transmembrane transporter activity
A4U85_RS03245	COG2814	Major facilitator Superfamily
A4U85_RS03260	COG1115	amino acid carrier protein
A4U85_RS03265	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4U85_RS03270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U85_RS03275	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A4U85_RS03300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4U85_RS03310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4U85_RS03315	COG1077	Cell shape determining protein MreB Mrl
A4U85_RS03320	COG1792	Involved in formation and maintenance of cell shape
A4U85_RS03325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4U85_RS03330	COG0424	maF-like protein
A4U85_RS03335	COG1530	ribonuclease E activity
A4U85_RS03340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U85_RS03350	COG0560	Phosphoserine phosphatase
A4U85_RS03360	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS03385	COG2207	Transcriptional regulator
A4U85_RS03405	COG1113	amino acid transport
A4U85_RS03410	COG2828	Protein conserved in bacteria
A4U85_RS03415	COG0142	geranyltranstransferase activity
A4U85_RS03420	COG2315	Protein conserved in bacteria
A4U85_RS03435	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4U85_RS03455	COG2194	sulfuric ester hydrolase activity
A4U85_RS03460	COG0745	RESPONSE REGULATOR receiver
A4U85_RS03465	COG0642	Histidine kinase
A4U85_RS03475	COG0004	ammonium transporteR
A4U85_RS03485	COG0583	DNA-binding transcription factor activity
A4U85_RS03505	COG0525	valine-tRNA ligase activity
A4U85_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS03525	COG0393	Putative heavy-metal-binding
A4U85_RS03530	COG0393	Putative heavy-metal-binding
A4U85_RS03535	COG1538	Outer membrane efflux protein
A4U85_RS03545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS03550	COG0671	phosphoesterase, PA-phosphatase related
A4U85_RS03580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A4U85_RS03595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4U85_RS03595	COG1648	precorrin-2 dehydrogenase activity
A4U85_RS03600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4U85_RS03615	COG0531	amino acid
A4U85_RS03630	COG0321	lipoyl(octanoyl) transferase activity
A4U85_RS03635	COG2921	Belongs to the UPF0250 family
A4U85_RS03670	COG2009	succinate dehydrogenase
A4U85_RS03675	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A4U85_RS03680	COG1053	succinate dehydrogenase
A4U85_RS03685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4U85_RS03705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U85_RS03725	COG2354	Protein conserved in bacteria
A4U85_RS03730	COG2321	neutral zinc metallopeptidase
A4U85_RS03750	COG2843	Capsule synthesis protein
A4U85_RS03765	COG0589	response to stress
A4U85_RS03785	COG0505	Belongs to the CarA family
A4U85_RS03815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4U85_RS03820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4U85_RS03870	COG0477	Major facilitator Superfamily
A4U85_RS03875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4U85_RS03890	COG1597	lipid kinase activity
A4U85_RS03895	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U85_RS03920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U85_RS03925	COG0584	glycerophosphoryl diester phosphodiesterase
A4U85_RS03945	COG0741	lytic transglycosylase activity
A4U85_RS03970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4U85_RS03985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U85_RS04020	COG0778	Nitroreductase
A4U85_RS04035	COG1929	Belongs to the glycerate kinase type-1 family
A4U85_RS04040	COG0243	molybdopterin cofactor binding
A4U85_RS04045	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4U85_RS04050	COG3339	Conserved Protein
A4U85_RS04060	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A4U85_RS04075	COG1113	amino acid transport
A4U85_RS04085	COG0019	diaminopimelate decarboxylase activity
A4U85_RS04100	COG2267	carboxylic ester hydrolase activity
A4U85_RS04105	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS04110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4U85_RS04140	COG0463	Glycosyl transferase, family 2
A4U85_RS04160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS04190	COG4591	ABC-type transport system involved in lipoprotein release permease component
A4U85_RS04195	COG1136	(ABC) transporter
A4U85_RS04200	COG0658	competence protein
A4U85_RS04200	COG2333	competence protein COMEC
A4U85_RS04210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A4U85_RS04210	COG0616	signal peptide processing
A4U85_RS04215	COG0596	Alpha beta hydrolase
A4U85_RS04220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4U85_RS04230	COG0628	permease
A4U85_RS04265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U85_RS04285	COG0823	Involved in the tonB-independent uptake of proteins
A4U85_RS04305	COG0824	Thioesterase
A4U85_RS04310	COG1473	amidohydrolase
A4U85_RS04330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4U85_RS04330	COG0047	phosphoribosylformylglycinamidine synthase activity
A4U85_RS04335	COG2814	Major facilitator Superfamily
A4U85_RS04345	COG1024	Enoyl-CoA hydratase
A4U85_RS04350	COG1051	belongs to the nudix hydrolase family
A4U85_RS04350	COG1056	cytidyltransferase-related domain
A4U85_RS04360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4U85_RS04375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4U85_RS04390	COG4625	pathogenesis
A4U85_RS04395	COG0583	DNA-binding transcription factor activity
A4U85_RS04400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A4U85_RS04405	COG4208	sulfate ABC transporter
A4U85_RS04410	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A4U85_RS04420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A4U85_RS04425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4U85_RS04430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4U85_RS04450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U85_RS04465	COG0681	Belongs to the peptidase S26 family
A4U85_RS04480	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4U85_RS04490	COG1381	Involved in DNA repair and RecF pathway recombination
A4U85_RS04495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A4U85_RS04505	COG4221	oxidoreductase activity
A4U85_RS04530	COG0443	Heat shock 70 kDa protein
A4U85_RS04540	COG0436	Aminotransferase
A4U85_RS04560	COG0556	nucleotide-excision repair
A4U85_RS04615	COG2070	2-Nitropropane dioxygenase
A4U85_RS04645	COG1215	transferase activity, transferring glycosyl groups
A4U85_RS04660	COG0415	Belongs to the DNA photolyase family
A4U85_RS04670	COG1252	NADH dehydrogenase
A4U85_RS04675	COG1686	Belongs to the peptidase S11 family
A4U85_RS04690	COG1187	pseudouridine synthase activity
A4U85_RS04710	COG0477	Major facilitator Superfamily
A4U85_RS04715	COG0583	DNA-binding transcription factor activity
A4U85_RS04720	COG1823	symporter activity
A4U85_RS04730	COG0612	Peptidase, M16
A4U85_RS04755	COG0352	thiamine-phosphate diphosphorylase activity
A4U85_RS04790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U85_RS04800	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS04815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4U85_RS04820	COG0076	glutamate decarboxylase activity
A4U85_RS04830	COG1522	sequence-specific DNA binding
A4U85_RS04835	COG3961	Belongs to the TPP enzyme family
A4U85_RS04840	COG1113	amino acid transport
A4U85_RS04845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4U85_RS04850	COG0573	inorganic phosphate transmembrane transporter activity
A4U85_RS04860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4U85_RS04865	COG0616	signal peptide processing
A4U85_RS04900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4U85_RS04905	COG1686	Belongs to the peptidase S11 family
A4U85_RS04930	COG0583	DNA-binding transcription factor activity
A4U85_RS04935	COG1067	ATP-dependent peptidase activity
A4U85_RS04960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A4U85_RS04980	COG1966	Carbon starvation protein
A4U85_RS04985	COG2879	small protein
A4U85_RS05020	COG1741	Belongs to the pirin family
A4U85_RS05030	COG2964	Protein conserved in bacteria
A4U85_RS05045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U85_RS05050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U85_RS05055	COG4605	iron ion homeostasis
A4U85_RS05060	COG4604	ABC transporter, ATP-binding protein
A4U85_RS05065	COG4607	ABC-type enterochelin transport system periplasmic component
A4U85_RS05070	COG4774	siderophore transport
A4U85_RS05080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4U85_RS05085	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4U85_RS05090	COG3433	isochorismatase activity
A4U85_RS05090	COG1535	isochorismatase
A4U85_RS05100	COG1132	(ABC) transporter
A4U85_RS05105	COG1132	(ABC) transporter
A4U85_RS05110	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A4U85_RS05120	COG1169	isochorismate synthase
A4U85_RS05135	COG3739	integral membrane protein
A4U85_RS05155	COG0302	gtp cyclohydrolase
A4U85_RS05165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4U85_RS05195	COG0308	aminopeptidase N
A4U85_RS05200	COG0512	Glutamine amidotransferase of anthranilate synthase
A4U85_RS05215	COG0174	glutamine synthetase
A4U85_RS05225	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A4U85_RS05260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4U85_RS05265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4U85_RS05270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4U85_RS05290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4U85_RS05295	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4U85_RS05300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A4U85_RS05315	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS05320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4U85_RS05325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U85_RS05335	COG2223	nitrite transmembrane transporter activity
A4U85_RS05345	COG0024	Methionine aminopeptidase
A4U85_RS05350	COG0052	Belongs to the universal ribosomal protein uS2 family
A4U85_RS05365	COG2207	Transcriptional regulator
A4U85_RS05390	COG2951	lytic endotransglycosylase activity
A4U85_RS05395	COG0772	Belongs to the SEDS family
A4U85_RS05410	COG0842	Transport permease protein
A4U85_RS05415	COG1131	(ABC) transporter
A4U85_RS05420	COG0582	viral genome integration into host DNA
A4U85_RS05425	COG3617	BRO family, N-terminal domain
A4U85_RS05455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U85_RS05825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS05840	COG4215	(ABC) transporter
A4U85_RS05845	COG4160	amino acid transport
A4U85_RS05850	COG4598	ABC transporter
A4U85_RS05860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U85_RS05865	COG0826	peptidase U32
A4U85_RS05870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U85_RS05885	COG1720	tRNA m6t6A37 methyltransferase activity
A4U85_RS05895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4U85_RS05900	COG3111	PFAM Bacterial OB fold (BOF) protein
A4U85_RS05910	COG0642	Histidine kinase
A4U85_RS05920	COG0494	nUDIX hydrolase
A4U85_RS05930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4U85_RS05935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4U85_RS05940	COG3139	Protein of unknown function (DUF1315)
A4U85_RS05945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4U85_RS05955	COG1301	dicarboxylic acid transport
A4U85_RS05960	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS05965	COG2819	hydrolase of the alpha beta superfamily
A4U85_RS05975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4U85_RS05985	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4U85_RS05990	COG1234	tRNA 3'-trailer cleavage
A4U85_RS06020	COG2363	Small membrane protein
A4U85_RS06040	COG0513	Belongs to the DEAD box helicase family
A4U85_RS06050	COG0778	Nitroreductase
A4U85_RS06080	COG1286	toxin biosynthetic process
A4U85_RS06105	COG4783	chaperone-mediated protein folding
A4U85_RS06110	COG1610	YqeY-like protein
A4U85_RS06210	COG3111	PFAM Bacterial OB fold (BOF) protein
A4U85_RS06235	COG3243	poly(R)-hydroxyalkanoic acid synthase
A4U85_RS06240	COG0786	glutamate:sodium symporter activity
A4U85_RS06250	COG2186	Transcriptional regulator
A4U85_RS06305	COG0477	Major facilitator Superfamily
A4U85_RS06310	COG1051	belongs to the nudix hydrolase family
A4U85_RS06340	COG2995	paraquat-inducible protein a
A4U85_RS06345	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4U85_RS06345	COG3008	intermembrane lipid transfer
A4U85_RS06355	COG2351	hydroxyisourate hydrolase activity
A4U85_RS06395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U85_RS06405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4U85_RS06410	COG0642	Histidine kinase
A4U85_RS06415	COG0745	RESPONSE REGULATOR receiver
A4U85_RS06435	COG1794	racemase activity, acting on amino acids and derivatives
A4U85_RS06465	COG1301	dicarboxylic acid transport
A4U85_RS06475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U85_RS06480	COG2011	ABC-type metal ion transport system permease component
A4U85_RS06485	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4U85_RS06490	COG1464	Belongs to the NlpA lipoprotein family
A4U85_RS06495	COG0151	Belongs to the GarS family
A4U85_RS06500	COG0138	bifunctional purine biosynthesis protein purh
A4U85_RS06505	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A4U85_RS06535	COG2308	Evidence 4 Homologs of previously reported genes of
A4U85_RS06545	COG1305	Transglutaminase-like
A4U85_RS06555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4U85_RS06560	COG0305	Participates in initiation and elongation during chromosome replication
A4U85_RS06585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4U85_RS06595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4U85_RS06600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4U85_RS06625	COG1649	PFAM Uncharacterised BCR, COG1649
A4U85_RS06625	COG0726	polysaccharide deacetylase
A4U85_RS06630	COG1215	transferase activity, transferring glycosyl groups
A4U85_RS06635	COG3658	cytochrome
A4U85_RS06645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U85_RS06665	COG0583	DNA-binding transcription factor activity
A4U85_RS06700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4U85_RS06705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U85_RS06730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4U85_RS06735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4U85_RS06745	COG2205	protein histidine kinase activity
A4U85_RS06750	COG0745	RESPONSE REGULATOR receiver
A4U85_RS06755	COG0174	glutamine synthetase
A4U85_RS06775	COG0729	surface antigen
A4U85_RS06805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4U85_RS06810	COG2814	Major facilitator Superfamily
A4U85_RS06825	COG0583	DNA-binding transcription factor activity
A4U85_RS06840	COG1187	pseudouridine synthase activity
A4U85_RS06860	COG0802	atpase or kinase
A4U85_RS06865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4U85_RS06875	COG1923	regulation of RNA biosynthetic process
A4U85_RS06880	COG0697	spore germination
A4U85_RS06895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U85_RS06905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4U85_RS06910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4U85_RS06910	COG0519	Catalyzes the synthesis of GMP from XMP
A4U85_RS06915	COG4302	ethanolamine ammonia-lyase activity
A4U85_RS06920	COG4303	Ethanolamine ammonia lyase large subunit
A4U85_RS06925	COG0531	amino acid
A4U85_RS06945	COG1454	alcohol dehydrogenase
A4U85_RS06950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U85_RS06975	COG0308	aminopeptidase N
A4U85_RS07015	COG1605	Chorismate mutase
A4U85_RS07035	COG1309	transcriptional regulator
A4U85_RS07045	COG0668	transmembrane transport
A4U85_RS07075	COG4773	Receptor
A4U85_RS07090	COG0488	(ABC) transporter
A4U85_RS07095	COG0589	response to stress
A4U85_RS07110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4U85_RS07120	COG3135	benzoate transporter
A4U85_RS07125	COG1522	sequence-specific DNA binding
A4U85_RS07135	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4U85_RS07140	COG0583	DNA-binding transcription factor activity
A4U85_RS07150	COG0183	Belongs to the thiolase family
A4U85_RS07160	COG2030	dehydratase
A4U85_RS07180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4U85_RS07190	COG0824	Thioesterase
A4U85_RS07195	COG1454	alcohol dehydrogenase
A4U85_RS07205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4U85_RS07225	COG0069	glutamate synthase activity
A4U85_RS07245	COG2814	Major facilitator Superfamily
A4U85_RS07260	COG0511	ligase activity, forming carbon-carbon bonds
A4U85_RS07275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U85_RS07275	COG1116	anion transmembrane transporter activity
A4U85_RS07280	COG0745	RESPONSE REGULATOR receiver
A4U85_RS07290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U85_RS07290	COG2146	nitrite reductase [NAD(P)H] activity
A4U85_RS07295	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U85_RS07300	COG0243	molybdopterin cofactor binding
A4U85_RS07310	COG0243	molybdopterin cofactor binding
A4U85_RS07320	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4U85_RS07335	COG0315	cyclic pyranopterin monophosphate synthase activity
A4U85_RS07335	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4U85_RS07340	COG0303	'Molybdopterin
A4U85_RS07350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U85_RS07355	COG0697	spore germination
A4U85_RS07375	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A4U85_RS07380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4U85_RS07440	COG2204	response regulator
A4U85_RS07445	COG3852	Histidine kinase
A4U85_RS07465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4U85_RS07470	COG0575	Belongs to the CDS family
A4U85_RS07505	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U85_RS07520	COG2137	regulation of response to DNA damage stimulus
A4U85_RS07530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4U85_RS07535	COG1011	Hydrolase
A4U85_RS07560	COG1522	sequence-specific DNA binding
A4U85_RS07570	COG1113	amino acid transport
A4U85_RS07585	COG0659	secondary active sulfate transmembrane transporter activity
A4U85_RS07590	COG2135	peptidase activity
A4U85_RS07605	COG5001	Diguanylate cyclase
A4U85_RS07605	COG3300	MHYT domain
A4U85_RS07625	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A4U85_RS07625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U85_RS07625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4U85_RS07630	COG1105	Belongs to the carbohydrate kinase PfkB family
A4U85_RS07635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4U85_RS07635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U85_RS07665	COG0024	Methionine aminopeptidase
A4U85_RS07670	COG0583	DNA-binding transcription factor activity
A4U85_RS07680	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A4U85_RS07685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4U85_RS07690	COG0517	IMP dehydrogenase activity
A4U85_RS07690	COG0516	GMP reductase activity
A4U85_RS07715	COG0552	protein localization to endoplasmic reticulum
A4U85_RS07725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A4U85_RS07735	COG4890	Cyd operon protein YbgT
A4U85_RS07740	COG1294	oxidase, subunit
A4U85_RS07755	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4U85_RS07765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4U85_RS07770	COG4774	siderophore transport
A4U85_RS07785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4U85_RS07790	COG0569	domain protein
A4U85_RS07795	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4U85_RS07825	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4U85_RS07830	COG0542	response to heat
A4U85_RS07855	COG1902	pentaerythritol trinitrate reductase activity
A4U85_RS07855	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U85_RS07900	COG2323	membrane
A4U85_RS07905	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4U85_RS07915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4U85_RS07920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4U85_RS07925	COG0183	Belongs to the thiolase family
A4U85_RS07930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4U85_RS07935	COG0596	Alpha beta hydrolase
A4U85_RS07940	COG2271	Major facilitator Superfamily
A4U85_RS07945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U85_RS07950	COG3485	protocatechuate 3,4-dioxygenase
A4U85_RS07955	COG3485	protocatechuate 3,4-dioxygenase
A4U85_RS07960	COG0710	3-dehydroquinate dehydratase activity
A4U85_RS07965	COG3420	alginic acid biosynthetic process
A4U85_RS07970	COG3659	wide pore channel activity
A4U85_RS07975	COG4993	Dehydrogenase
A4U85_RS07985	COG2391	methyltransferase activity
A4U85_RS08000	COG1414	Transcriptional regulator
A4U85_RS08005	COG0583	DNA-binding transcription factor activity
A4U85_RS08010	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS08035	COG2814	Major facilitator Superfamily
A4U85_RS08045	COG0154	amidase activity
A4U85_RS08065	COG4638	Rieske (2fe-2S)
A4U85_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U85_RS08095	COG3733	amine oxidase
A4U85_RS08105	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS08115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4U85_RS08120	COG0183	Belongs to the thiolase family
A4U85_RS08125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4U85_RS08130	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4U85_RS08140	COG4829	muconolactone delta-isomerase
A4U85_RS08145	COG4948	Mandelate Racemase Muconate Lactonizing
A4U85_RS08150	COG0583	DNA-binding transcription factor activity
A4U85_RS08160	COG2186	Transcriptional regulator
A4U85_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS08195	COG1902	pentaerythritol trinitrate reductase activity
A4U85_RS08195	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U85_RS08210	COG0789	Transcriptional regulator
A4U85_RS08235	COG1309	transcriptional regulator
A4U85_RS08240	COG0583	DNA-binding transcription factor activity
A4U85_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08250	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08265	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS08275	COG0318	PFAM AMP-dependent synthetase and ligase
A4U85_RS08295	COG2831	hemolysin activation secretion protein
A4U85_RS08300	COG3210	domain, Protein
A4U85_RS08330	COG2188	Transcriptional regulator
A4U85_RS08345	COG0583	DNA-binding transcription factor activity
A4U85_RS08360	COG1566	PFAM secretion protein HlyD family protein
A4U85_RS08375	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS08380	COG0129	dihydroxy-acid dehydratase activity
A4U85_RS08390	COG0583	DNA-binding transcription factor activity
A4U85_RS08395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4U85_RS08405	COG2084	Dehydrogenase
A4U85_RS08410	COG2207	Transcriptional regulator
A4U85_RS08425	COG1064	alcohol dehydrogenase
A4U85_RS08435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4U85_RS08440	COG1120	ATPase activity
A4U85_RS08460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4U85_RS08505	COG1401	restriction endodeoxyribonuclease activity
A4U85_RS08575	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4U85_RS08620	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
A4U85_RS08635	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08650	COG2207	Transcriptional regulator
A4U85_RS08660	COG2205	protein histidine kinase activity
A4U85_RS08665	COG0745	RESPONSE REGULATOR receiver
A4U85_RS08670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS08675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U85_RS08715	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4U85_RS08725	COG0753	catalase activity
A4U85_RS08740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4U85_RS08800	COG1535	isochorismatase
A4U85_RS08800	COG3433	isochorismatase activity
A4U85_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08810	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4U85_RS08815	COG4149	molybdate abc transporter
A4U85_RS08820	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4U85_RS08830	COG4638	Rieske (2fe-2S)
A4U85_RS08835	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A4U85_RS08840	COG0543	2 iron, 2 sulfur cluster binding
A4U85_RS08840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U85_RS08855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U85_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08880	COG2207	Transcriptional regulator
A4U85_RS08885	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS08890	COG2610	gluconate transmembrane transporter activity
A4U85_RS08900	COG1309	transcriptional regulator
A4U85_RS08920	COG0583	DNA-binding transcription factor activity
A4U85_RS08935	COG2031	fatty acid transporter
A4U85_RS08940	COG0183	Belongs to the thiolase family
A4U85_RS08945	COG0583	DNA-binding transcription factor activity
A4U85_RS08950	COG0583	DNA-binding transcription factor activity
A4U85_RS08965	COG1027	Aspartate ammonia-lyase
A4U85_RS08975	COG0477	Major facilitator Superfamily
A4U85_RS08995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U85_RS09000	COG4521	taurine ABC transporter
A4U85_RS09015	COG2188	Transcriptional regulator
A4U85_RS09025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4U85_RS09030	COG1733	regulation of RNA biosynthetic process
A4U85_RS09035	COG2207	Transcriptional regulator
A4U85_RS09035	COG3708	Transcriptional regulator
A4U85_RS09050	COG0730	response to heat
A4U85_RS09060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U85_RS09060	COG3453	Protein conserved in bacteria
A4U85_RS09070	COG3781	membrane
A4U85_RS09075	COG1063	alcohol dehydrogenase
A4U85_RS09085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4U85_RS09090	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4U85_RS09095	COG0022	dehydrogenase e1 component
A4U85_RS09100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4U85_RS09105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4U85_RS09120	COG3706	GGDEF domain
A4U85_RS09135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A4U85_RS09140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4U85_RS09165	COG2226	methyltransferase
A4U85_RS09220	COG0842	Transport permease protein
A4U85_RS09225	COG0842	Transport permease protein
A4U85_RS09230	COG1131	(ABC) transporter
A4U85_RS09245	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4U85_RS09250	COG4773	Receptor
A4U85_RS09270	COG0730	response to heat
A4U85_RS09275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4U85_RS09290	COG0406	alpha-ribazole phosphatase activity
A4U85_RS09340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U85_RS09350	COG4264	IucA IucC family
A4U85_RS09355	COG4264	IucA IucC family
A4U85_RS09375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4U85_RS09390	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS09395	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS09400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4U85_RS09405	COG2207	Transcriptional regulator
A4U85_RS09410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U85_RS09415	COG0776	regulation of translation
A4U85_RS09440	COG0822	iron-sulfur transferase activity
A4U85_RS09445	COG0316	Belongs to the HesB IscA family
A4U85_RS09475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4U85_RS09495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A4U85_RS09500	COG0702	epimerase
A4U85_RS09535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4U85_RS09545	COG0339	signal peptide processing
A4U85_RS09560	COG4206	TonB-dependent receptor
A4U85_RS09590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A4U85_RS09595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A4U85_RS09625	COG0776	regulation of translation
A4U85_RS09690	COG0084	hydrolase, TatD family'
A4U85_RS09710	COG1663	tetraacyldisaccharide 4'-kinase activity
A4U85_RS09715	COG1132	(ABC) transporter
A4U85_RS09725	COG0811	peptide transport
A4U85_RS09730	COG1475	DNA binding
A4U85_RS09735	COG1192	Involved in chromosome partitioning
A4U85_RS09745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4U85_RS09760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4U85_RS09765	COG0191	fructose-bisphosphate aldolase activity
A4U85_RS09785	COG0424	maF-like protein
A4U85_RS09790	COG2850	peptidyl-arginine hydroxylation
A4U85_RS09800	COG0640	Transcriptional regulator
A4U85_RS09810	COG3619	membrane
A4U85_RS09815	COG3122	Protein conserved in bacteria
A4U85_RS09820	COG1132	(ABC) transporter
A4U85_RS09840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4U85_RS09845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4U85_RS09855	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4U85_RS09855	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A4U85_RS09855	COG0506	proline dehydrogenase activity
A4U85_RS09860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4U85_RS09875	COG3698	Phosphodiester glycosidase
A4U85_RS09885	COG2353	YceI-like domain
A4U85_RS09895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4U85_RS09940	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4U85_RS09940	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4U85_RS09965	COG3539	Fimbrial protein
A4U85_RS09970	COG3121	Chaperone
A4U85_RS10000	COG0697	spore germination
A4U85_RS10010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4U85_RS10020	COG0583	DNA-binding transcription factor activity
A4U85_RS10050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4U85_RS10060	COG1061	Type III restriction enzyme res subunit
A4U85_RS10065	COG1002	Type II restriction enzyme, methylase subunits
A4U85_RS10080	COG4584	PFAM Integrase catalytic
A4U85_RS10085	COG1484	DNA-dependent DNA replication
A4U85_RS10095	COG1309	transcriptional regulator
A4U85_RS10110	COG1522	sequence-specific DNA binding
A4U85_RS10120	COG1126	abc transporter atp-binding protein
A4U85_RS10125	COG0765	amino acid transport
A4U85_RS10130	COG0765	amino acid transport
A4U85_RS10160	COG1464	Belongs to the NlpA lipoprotein family
A4U85_RS10170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4U85_RS10175	COG2011	ABC-type metal ion transport system permease component
A4U85_RS10180	COG0012	GTP binding
A4U85_RS10205	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4U85_RS10245	COG0386	Belongs to the glutathione peroxidase family
A4U85_RS10255	COG0436	Aminotransferase
A4U85_RS10295	COG3634	alkyl hydroperoxide reductase activity
A4U85_RS10310	COG0583	DNA-binding transcription factor activity
A4U85_RS10315	COG0798	PFAM Bile acid sodium symporter
A4U85_RS10320	COG0640	Transcriptional regulator
A4U85_RS10335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4U85_RS10345	COG0583	DNA-binding transcription factor activity
A4U85_RS10355	COG1953	Uracil, thiamine, allantoin
A4U85_RS10365	COG2175	clavaminate synthase activity
A4U85_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U85_RS10375	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A4U85_RS10380	COG4521	taurine ABC transporter
A4U85_RS10390	COG0477	Major facilitator Superfamily
A4U85_RS10415	COG1271	oxidase subunit
A4U85_RS10420	COG1294	oxidase, subunit
A4U85_RS10430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U85_RS10470	COG3052	prosthetic group binding
A4U85_RS10485	COG0583	DNA-binding transcription factor activity
A4U85_RS10495	COG2814	Major facilitator Superfamily
A4U85_RS10515	COG1346	cytolysis
A4U85_RS10525	COG0583	DNA-binding transcription factor activity
A4U85_RS10530	COG0625	glutathione transferase activity
A4U85_RS10535	COG0625	glutathione transferase activity
A4U85_RS10540	COG0583	DNA-binding transcription factor activity
A4U85_RS10555	COG1045	serine acetyltransferase
A4U85_RS10560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4U85_RS10565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4U85_RS10570	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS10580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U85_RS10585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U85_RS10590	COG1126	abc transporter atp-binding protein
A4U85_RS10595	COG0765	amino acid transport
A4U85_RS10600	COG0765	amino acid transport
A4U85_RS10615	COG0784	Response regulator, receiver
A4U85_RS10615	COG2205	protein histidine kinase activity
A4U85_RS10635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4U85_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS10700	COG0583	DNA-binding transcription factor activity
A4U85_RS10720	COG0318	PFAM AMP-dependent synthetase and ligase
A4U85_RS10725	COG1309	transcriptional regulator
A4U85_RS10730	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS10735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4U85_RS10740	COG1024	Enoyl-CoA hydratase
A4U85_RS10745	COG4770	biotin carboxylase activity
A4U85_RS10755	COG0583	DNA-binding transcription factor activity
A4U85_RS10770	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS10780	COG2814	Major facilitator Superfamily
A4U85_RS10790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4U85_RS10795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4U85_RS10800	COG2814	Major facilitator Superfamily
A4U85_RS10805	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS10810	COG1024	Enoyl-CoA hydratase
A4U85_RS10815	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS10820	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U85_RS10825	COG0183	Belongs to the thiolase family
A4U85_RS10835	COG2814	Major facilitator Superfamily
A4U85_RS10845	COG1024	Enoyl-CoA hydratase
A4U85_RS10860	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS10865	COG2814	Major facilitator Superfamily
A4U85_RS10870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4U85_RS10875	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4U85_RS10890	COG3842	ATPase activity
A4U85_RS10895	COG1840	ABC-type Fe3 transport system, periplasmic component
A4U85_RS10905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U85_RS10910	COG1414	Transcriptional regulator
A4U85_RS10920	COG0583	DNA-binding transcription factor activity
A4U85_RS10925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4U85_RS10930	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS10940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4U85_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS10950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U85_RS10975	COG3038	cytochrome b561
A4U85_RS10980	COG0753	catalase activity
A4U85_RS10985	COG2271	Major facilitator Superfamily
A4U85_RS10990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4U85_RS10995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4U85_RS11010	COG2207	Transcriptional regulator
A4U85_RS11055	COG2050	protein possibly involved in aromatic compounds catabolism
A4U85_RS11065	COG3327	negative regulation of DNA-templated transcription, initiation
A4U85_RS11070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4U85_RS11075	COG0183	Belongs to the thiolase family
A4U85_RS11080	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U85_RS11085	COG1024	Enoyl-CoA hydratase
A4U85_RS11090	COG1024	Enoyl-CoA hydratase
A4U85_RS11095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U85_RS11100	COG2151	metal-sulfur cluster biosynthetic enzyme
A4U85_RS11105	COG3396	Phenylacetate-CoA oxygenase
A4U85_RS11110	COG3460	Phenylacetate-CoA oxygenase
A4U85_RS11115	COG3396	Phenylacetate-CoA oxygenase
A4U85_RS11120	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS11120	COG2030	dehydratase
A4U85_RS11125	COG1760	l-serine dehydratase
A4U85_RS11130	COG0531	amino acid
A4U85_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS11180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U85_RS11205	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4U85_RS11220	COG2807	transmembrane transport
A4U85_RS11225	COG0590	tRNA wobble adenosine to inosine editing
A4U85_RS11345	COG1116	anion transmembrane transporter activity
A4U85_RS11350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4U85_RS11360	COG0864	Transcriptional regulator
A4U85_RS11375	COG1733	regulation of RNA biosynthetic process
A4U85_RS11380	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS11385	COG0439	Biotin carboxylase
A4U85_RS11400	COG1063	alcohol dehydrogenase
A4U85_RS11410	COG1309	transcriptional regulator
A4U85_RS11425	COG3210	domain, Protein
A4U85_RS11430	COG2831	hemolysin activation secretion protein
A4U85_RS11435	COG0038	chloride channel
A4U85_RS11440	COG4770	biotin carboxylase activity
A4U85_RS11460	COG1914	H( )-stimulated, divalent metal cation uptake system
A4U85_RS11465	COG0583	DNA-binding transcription factor activity
A4U85_RS11500	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4U85_RS11520	COG2814	Major facilitator Superfamily
A4U85_RS11535	COG1560	Kdo2-lipid A biosynthetic process
A4U85_RS11550	COG1522	sequence-specific DNA binding
A4U85_RS11565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4U85_RS11575	COG4122	O-methyltransferase activity
A4U85_RS11605	COG1538	Outer membrane efflux protein
A4U85_RS11650	COG1137	ATPase activity
A4U85_RS11655	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A4U85_RS11665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4U85_RS11670	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4U85_RS11670	COG0517	IMP dehydrogenase activity
A4U85_RS11875	COG5377	YqaJ viral recombinase family
A4U85_RS11885	COG0210	DNA helicase
A4U85_RS11970	COG2814	Major facilitator Superfamily
A4U85_RS12005	COG1278	Cold shock
A4U85_RS12010	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS12045	COG1570	exodeoxyribonuclease VII activity
A4U85_RS12100	COG0583	DNA-binding transcription factor activity
A4U85_RS12105	COG4638	Rieske (2fe-2S)
A4U85_RS12110	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A4U85_RS12115	COG0633	Ferredoxin
A4U85_RS12115	COG0543	2 iron, 2 sulfur cluster binding
A4U85_RS12120	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS12125	COG3135	benzoate transporter
A4U85_RS12130	COG2814	Major facilitator Superfamily
A4U85_RS12145	COG1643	Atp-dependent helicase
A4U85_RS12150	COG0450	alkyl hydroperoxide reductase
A4U85_RS12160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A4U85_RS12170	COG3634	alkyl hydroperoxide reductase activity
A4U85_RS12190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4U85_RS12210	COG0625	glutathione transferase activity
A4U85_RS12220	COG2885	chlorophyll binding
A4U85_RS12255	COG0542	response to heat
A4U85_RS12270	COG1765	OsmC-like protein
A4U85_RS12280	COG0667	Aldo Keto reductase
A4U85_RS12295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4U85_RS12305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4U85_RS12315	COG0582	viral genome integration into host DNA
A4U85_RS12445	COG3566	protein conserved in bacteria
A4U85_RS12470	COG3567	Phage-associated protein, HI1409 family
A4U85_RS12475	COG5410	chromosome segregation
A4U85_RS12560	COG4197	protein conserved in bacteria, prophage-related
A4U85_RS12565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4U85_RS12620	COG0527	aspartate kinase activity
A4U85_RS12630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4U85_RS12640	COG3038	cytochrome b561
A4U85_RS12645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4U85_RS12650	COG2252	PERMEase
A4U85_RS12660	COG2072	flavoprotein involved in K transport
A4U85_RS12675	COG1741	Belongs to the pirin family
A4U85_RS12680	COG1309	transcriptional regulator
A4U85_RS12690	COG0300	oxidoreductase activity
A4U85_RS12695	COG2072	flavoprotein involved in K transport
A4U85_RS12700	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A4U85_RS12745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4U85_RS12760	COG2814	Major facilitator Superfamily
A4U85_RS12765	COG1024	Enoyl-CoA hydratase
A4U85_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS12780	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS12805	COG2186	Transcriptional regulator
A4U85_RS12810	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS12820	COG4948	Mandelate Racemase Muconate Lactonizing
A4U85_RS12825	COG2271	Major facilitator Superfamily
A4U85_RS12830	COG2721	sulfolactate sulfo-lyase activity
A4U85_RS12835	COG0697	spore germination
A4U85_RS12870	COG1113	amino acid transport
A4U85_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS12910	COG0531	amino acid
A4U85_RS12920	COG1113	amino acid transport
A4U85_RS12965	COG4269	membrane
A4U85_RS12980	COG1309	transcriptional regulator
A4U85_RS13005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A4U85_RS13015	COG2184	nucleotidyltransferase activity
A4U85_RS13075	COG0789	Transcriptional regulator
A4U85_RS13155	COG0582	viral genome integration into host DNA
A4U85_RS13165	COG1902	pentaerythritol trinitrate reductase activity
A4U85_RS13165	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4U85_RS13175	COG2203	Gaf domain
A4U85_RS13175	COG3706	GGDEF domain
A4U85_RS13175	COG4251	negative regulation of phosphorylation
A4U85_RS13175	COG5001	Diguanylate cyclase
A4U85_RS13185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U85_RS13205	COG4172	Belongs to the ABC transporter superfamily
A4U85_RS13210	COG4239	(ABC) transporter, permease
A4U85_RS13215	COG4174	ABC transporter (Permease)
A4U85_RS13225	COG0741	lytic transglycosylase activity
A4U85_RS13225	COG1388	LysM domain
A4U85_RS13225	COG0741	lytic transglycosylase activity
A4U85_RS13225	COG1388	LysM domain
A4U85_RS13230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4U85_RS13270	COG0583	DNA-binding transcription factor activity
A4U85_RS13275	COG1279	arginine transmembrane transporter activity
A4U85_RS13295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U85_RS13300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U85_RS13305	COG0006	proline dipeptidase activity
A4U85_RS13340	COG2194	sulfuric ester hydrolase activity
A4U85_RS13385	COG0739	heme binding
A4U85_RS13705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4U85_RS13730	COG3384	dioxygenase
A4U85_RS13740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4U85_RS13745	COG2878	Part of a membrane complex involved in electron transport
A4U85_RS13750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4U85_RS13770	COG0768	penicillin binding
A4U85_RS13775	COG0742	ribosomal rna small subunit methyltransferase
A4U85_RS13790	COG0830	nickel cation binding
A4U85_RS13800	COG0804	urea catabolic process
A4U85_RS13840	COG1253	flavin adenine dinucleotide binding
A4U85_RS13850	COG2851	Citrate transporter
A4U85_RS13895	COG1773	rubredoxin
A4U85_RS13900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4U85_RS13910	COG0583	DNA-binding transcription factor activity
A4U85_RS13935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A4U85_RS13940	COG4181	ATPase activity
A4U85_RS13985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A4U85_RS14000	COG0306	phosphate transporter
A4U85_RS14010	COG3958	Transketolase
A4U85_RS14015	COG3959	Transketolase, thiamine diphosphate binding domain
A4U85_RS14020	COG2271	Major facilitator Superfamily
A4U85_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS14030	COG0583	DNA-binding transcription factor activity
A4U85_RS14050	COG2223	nitrite transmembrane transporter activity
A4U85_RS14055	COG2207	Transcriptional regulator
A4U85_RS14060	COG2066	Belongs to the glutaminase family
A4U85_RS14065	COG0242	peptide deformylase activity
A4U85_RS14070	COG0477	Major facilitator Superfamily
A4U85_RS14080	COG0028	Belongs to the TPP enzyme family
A4U85_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS14100	COG2267	carboxylic ester hydrolase activity
A4U85_RS14110	COG2271	Major facilitator Superfamily
A4U85_RS14125	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS14145	COG1414	Transcriptional regulator
A4U85_RS14160	COG1024	Enoyl-CoA hydratase
A4U85_RS14170	COG1215	transferase activity, transferring glycosyl groups
A4U85_RS14175	COG1649	PFAM Uncharacterised BCR, COG1649
A4U85_RS14175	COG0726	polysaccharide deacetylase
A4U85_RS14185	COG4681	YaeQ
A4U85_RS14195	COG0523	cobalamin synthesis protein
A4U85_RS14205	COG1607	acyl-coa hydrolase
A4U85_RS14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4U85_RS14220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4U85_RS14225	COG1309	transcriptional regulator
A4U85_RS14250	COG2040	homocysteine
A4U85_RS14255	COG0531	amino acid
A4U85_RS14300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U85_RS14305	COG0477	Major facilitator Superfamily
A4U85_RS14480	COG0582	viral genome integration into host DNA
A4U85_RS14490	COG0405	Gamma-glutamyltransferase
A4U85_RS14495	COG2814	Major facilitator Superfamily
A4U85_RS14505	COG2050	protein possibly involved in aromatic compounds catabolism
A4U85_RS14520	COG1090	epimerase
A4U85_RS14540	COG0420	3'-5' exonuclease activity
A4U85_RS14565	COG0735	belongs to the Fur family
A4U85_RS14570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4U85_RS14595	COG0121	glutamine amidotransferase
A4U85_RS14610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4U85_RS14620	COG0210	DNA helicase
A4U85_RS14625	COG2885	chlorophyll binding
A4U85_RS14630	COG0204	Acyl-transferase
A4U85_RS14645	COG2894	cell division
A4U85_RS14660	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS14665	COG1674	ftsk spoiiie
A4U85_RS14670	COG0492	ferredoxin-NADP+ reductase activity
A4U85_RS14675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A4U85_RS14685	COG0456	acetyltransferase
A4U85_RS14730	COG1981	membrane
A4U85_RS14745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4U85_RS14745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U85_RS14765	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS14775	COG0657	acetylesterase activity
A4U85_RS14785	COG0473	3-isopropylmalate dehydrogenase activity
A4U85_RS14790	COG0583	DNA-binding transcription factor activity
A4U85_RS14810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U85_RS14835	COG0564	pseudouridine synthase activity
A4U85_RS14845	COG0358	DNA primase activity
A4U85_RS14860	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A4U85_RS14890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4U85_RS14920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4U85_RS14930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4U85_RS14930	COG0352	thiamine-phosphate diphosphorylase activity
A4U85_RS14930	COG0351	phosphomethylpyrimidine kinase
A4U85_RS14935	COG1652	LysM domain
A4U85_RS14960	COG1399	metal-binding, possibly nucleic acid-binding protein
A4U85_RS14965	COG3101	peptidyl-lysine hydroxylation
A4U85_RS14970	COG0009	L-threonylcarbamoyladenylate synthase
A4U85_RS14975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4U85_RS14980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4U85_RS14995	COG4106	trans-aconitate 2-methyltransferase activity
A4U85_RS15010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4U85_RS15010	COG0596	Alpha beta hydrolase
A4U85_RS15010	COG2226	methyltransferase
A4U85_RS15015	COG1877	trehalose-phosphatase activity
A4U85_RS15020	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A4U85_RS15025	COG2223	nitrite transmembrane transporter activity
A4U85_RS15045	COG1196	nuclear chromosome segregation
A4U85_RS15055	COG0730	response to heat
A4U85_RS15070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4U85_RS15080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4U85_RS15125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U85_RS15135	COG0489	protein tyrosine kinase activity
A4U85_RS15145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U85_RS15145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U85_RS15175	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A4U85_RS15180	COG2081	HI0933 family
A4U85_RS15185	COG0668	transmembrane transport
A4U85_RS15205	COG0583	DNA-binding transcription factor activity
A4U85_RS15225	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4U85_RS15230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4U85_RS15260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A4U85_RS15300	COG0745	RESPONSE REGULATOR receiver
A4U85_RS15320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4U85_RS15380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4U85_RS15395	COG0583	DNA-binding transcription factor activity
A4U85_RS15405	COG0583	DNA-binding transcription factor activity
A4U85_RS15425	COG0583	DNA-binding transcription factor activity
A4U85_RS15430	COG1053	succinate dehydrogenase
A4U85_RS15445	COG1309	transcriptional regulator
A4U85_RS15450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A4U85_RS15455	COG2814	Major facilitator Superfamily
A4U85_RS15460	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS15465	COG0583	DNA-binding transcription factor activity
A4U85_RS15470	COG1063	alcohol dehydrogenase
A4U85_RS15500	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4U85_RS15505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4U85_RS15510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U85_RS15530	COG2132	Multicopper oxidase
A4U85_RS15540	COG0561	phosphatase activity
A4U85_RS15545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4U85_RS15555	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A4U85_RS15570	COG1214	PFAM Peptidase M22, glycoprotease
A4U85_RS15620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4U85_RS15630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4U85_RS15635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4U85_RS15640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4U85_RS15700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4U85_RS15710	COG1846	Transcriptional regulator
A4U85_RS15715	COG1764	response to oxidative stress
A4U85_RS15740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4U85_RS15740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4U85_RS15755	COG0037	tRNA processing
A4U85_RS15765	COG0248	Ppx GppA phosphatase
A4U85_RS15790	COG0072	phenylalanine-tRNA ligase activity
A4U85_RS15835	COG1238	metal cluster binding
A4U85_RS15840	COG0625	glutathione transferase activity
A4U85_RS15860	COG0318	PFAM AMP-dependent synthetase and ligase
A4U85_RS15865	COG3028	Belongs to the UPF0307 family
A4U85_RS15870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4U85_RS15890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4U85_RS15895	COG0617	tRNA 3'-terminal CCA addition
A4U85_RS15900	COG1555	photosystem II stabilization
A4U85_RS15905	COG3956	TIGRFAM MazG family protein
A4U85_RS15915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4U85_RS15935	COG5002	protein histidine kinase activity
A4U85_RS15935	COG2205	protein histidine kinase activity
A4U85_RS15935	COG0784	Response regulator, receiver
A4U85_RS15940	COG1024	Enoyl-CoA hydratase
A4U85_RS15945	COG2084	Dehydrogenase
A4U85_RS15950	COG3622	Belongs to the hyi family
A4U85_RS15980	COG0697	spore germination
A4U85_RS15990	COG2814	Major facilitator Superfamily
A4U85_RS15995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4U85_RS16005	COG0583	DNA-binding transcription factor activity
A4U85_RS16010	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4U85_RS16025	COG0084	hydrolase, TatD family'
A4U85_RS16040	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4U85_RS16075	COG0440	acetolactate synthase activity
A4U85_RS16080	COG0028	Belongs to the TPP enzyme family
A4U85_RS16110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4U85_RS16115	COG0577	efflux transmembrane transporter activity
A4U85_RS16115	COG1136	(ABC) transporter
A4U85_RS16120	COG1538	Outer membrane efflux protein
A4U85_RS16135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4U85_RS16140	COG1162	GTPase activity
A4U85_RS16150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4U85_RS16190	COG1426	Protein conserved in bacteria
A4U85_RS16225	COG0793	Belongs to the peptidase S41A family
A4U85_RS16240	COG2267	carboxylic ester hydrolase activity
A4U85_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
A4U85_RS16255	COG3265	gluconokinase activity
A4U85_RS16265	COG0800	Aldolase
A4U85_RS16275	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4U85_RS16280	COG0280	phosphate acetyltransferase
A4U85_RS16280	COG0857	belongs to the CobB CobQ family
A4U85_RS16285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U85_RS16285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4U85_RS16305	COG0740	serine-type endopeptidase activity
A4U85_RS16315	COG4774	siderophore transport
A4U85_RS16325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4U85_RS16335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A4U85_RS16335	COG2813	Specifically methylates the guanine in position
A4U85_RS16480	COG0788	formyltetrahydrofolate deformylase activity
A4U85_RS16505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U85_RS16505	COG4651	solute:proton antiporter activity
A4U85_RS16525	COG0724	RNA recognition motif
A4U85_RS16530	COG0210	DNA helicase
A4U85_RS16555	COG1733	regulation of RNA biosynthetic process
A4U85_RS16565	COG2900	Belongs to the SlyX family
A4U85_RS16570	COG0488	(ABC) transporter
A4U85_RS16575	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS16580	COG1560	Kdo2-lipid A biosynthetic process
A4U85_RS16590	COG1301	dicarboxylic acid transport
A4U85_RS16645	COG0473	3-isopropylmalate dehydrogenase activity
A4U85_RS16710	COG0583	DNA-binding transcription factor activity
A4U85_RS16720	COG0625	glutathione transferase activity
A4U85_RS16725	COG2378	regulation of single-species biofilm formation
A4U85_RS16730	COG0546	phosphoglycolate phosphatase activity
A4U85_RS16745	COG1530	ribonuclease E activity
A4U85_RS16750	COG0318	PFAM AMP-dependent synthetase and ligase
A4U85_RS16765	COG0583	DNA-binding transcription factor activity
A4U85_RS16770	COG4221	oxidoreductase activity
A4U85_RS16775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4U85_RS16785	COG0534	Mate efflux family protein
A4U85_RS16800	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A4U85_RS16830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4U85_RS16830	COG0493	'glutamate synthase
A4U85_RS16840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A4U85_RS16845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4U85_RS16860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4U85_RS16870	COG0644	oxidoreductase
A4U85_RS16870	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A4U85_RS16875	COG0425	Belongs to the sulfur carrier protein TusA family
A4U85_RS16880	COG4535	Mg2 and Co2 transporter CorC
A4U85_RS16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4U85_RS16910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4U85_RS16915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4U85_RS16915	COG0475	glutathione-regulated potassium exporter activity
A4U85_RS16930	COG0484	heat shock protein binding
A4U85_RS16935	COG0789	Transcriptional regulator
A4U85_RS16940	COG0598	Magnesium transport protein CorA
A4U85_RS16955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4U85_RS16960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4U85_RS16965	COG1074	ATP-dependent DNA helicase activity
A4U85_RS16970	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A4U85_RS16990	COG2226	methyltransferase
A4U85_RS17005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4U85_RS17010	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4U85_RS17025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4U85_RS17025	COG2111	Na H antiporter
A4U85_RS17030	COG1006	Multisubunit Na H antiporter MnhC subunit
A4U85_RS17035	COG0651	ATP synthesis coupled electron transport
A4U85_RS17040	COG1863	multisubunit Na H antiporter MnhE subunit
A4U85_RS17045	COG2212	antiporter activity
A4U85_RS17050	COG1320	monovalent cation:proton antiporter activity
A4U85_RS17065	COG0195	Participates in both transcription termination and antitermination
A4U85_RS17110	COG0237	dephospho-CoA kinase activity
A4U85_RS17120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4U85_RS17135	COG0497	DNA recombination
A4U85_RS17145	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4U85_RS17175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4U85_RS17175	COG2169	Transcriptional regulator
A4U85_RS17180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4U85_RS17240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4U85_RS17255	COG0326	Molecular chaperone. Has ATPase activity
A4U85_RS17270	COG2056	Na+-H+ antiporter family
A4U85_RS17370	COG0546	phosphoglycolate phosphatase activity
A4U85_RS17375	COG1716	ATPase activity
A4U85_RS17420	COG0181	hydroxymethylbilane synthase activity
A4U85_RS17430	COG3275	phosphorelay sensor kinase activity
A4U85_RS17450	COG1538	Outer membrane efflux protein
A4U85_RS17455	COG0697	spore germination
A4U85_RS17480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4U85_RS17485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4U85_RS17490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4U85_RS17495	COG0772	Belongs to the SEDS family
A4U85_RS17520	COG4974	Belongs to the 'phage' integrase family
A4U85_RS17525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U85_RS17535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4U85_RS17545	COG2197	response regulator
A4U85_RS17560	COG0793	Belongs to the peptidase S41A family
A4U85_RS17565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4U85_RS17570	COG0795	lipopolysaccharide-transporting ATPase activity
A4U85_RS17610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U85_RS17610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4U85_RS17620	COG0004	ammonium transporteR
A4U85_RS17625	COG0347	Belongs to the P(II) protein family
A4U85_RS17635	COG0606	chelatase, subunit chli
A4U85_RS17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4U85_RS17650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4U85_RS17665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A4U85_RS17680	COG0318	PFAM AMP-dependent synthetase and ligase
A4U85_RS17690	COG0477	Major facilitator Superfamily
A4U85_RS17695	COG2860	membrane
A4U85_RS17705	COG1253	flavin adenine dinucleotide binding
A4U85_RS17715	COG2814	Major facilitator Superfamily
A4U85_RS17725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4U85_RS17760	COG0655	NAD(P)H dehydrogenase (quinone) activity
A4U85_RS17770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4U85_RS17805	COG1309	transcriptional regulator
A4U85_RS17840	COG0758	DNA mediated transformation
A4U85_RS17850	COG0697	spore germination
A4U85_RS17855	COG1309	transcriptional regulator
A4U85_RS17870	COG0386	Belongs to the glutathione peroxidase family
A4U85_RS17935	COG1121	(ABC) transporter
A4U85_RS17940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4U85_RS17945	COG1280	lysine exporter protein (LysE YggA)
A4U85_RS17950	COG2837	iron assimilation
A4U85_RS17955	COG0281	malic enzyme
A4U85_RS18000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4U85_RS18000	COG0519	Catalyzes the synthesis of GMP from XMP
A4U85_RS18005	COG4399	Belongs to the UPF0754 family
A4U85_RS18010	COG2259	Doxx family
A4U85_RS18015	COG0586	Pfam SNARE associated Golgi protein
A4U85_RS18030	COG1192	Involved in chromosome partitioning
A4U85_RS18040	COG0271	Belongs to the BolA IbaG family
A4U85_RS18060	COG2267	carboxylic ester hydrolase activity
A4U85_RS18080	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A4U85_RS18080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4U85_RS18080	COG3321	synthase
A4U85_RS18080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A4U85_RS18085	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS18095	COG2197	response regulator
A4U85_RS18105	COG3916	Acyl-homoserine-lactone synthase
A4U85_RS18110	COG0477	Major facilitator Superfamily
A4U85_RS18115	COG1024	Enoyl-CoA hydratase
A4U85_RS18120	COG1024	Enoyl-CoA hydratase
A4U85_RS18125	COG1960	acyl-CoA dehydrogenase activity
A4U85_RS18130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4U85_RS18150	COG1113	amino acid transport
A4U85_RS18155	COG1113	amino acid transport
A4U85_RS18160	COG0251	oxidation-reduction process
A4U85_RS18200	COG0564	pseudouridine synthase activity
A4U85_RS18290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4U85_RS18305	COG1802	Transcriptional regulator
A4U85_RS18310	COG1448	Aminotransferase
A4U85_RS18315	COG0277	FAD linked oxidase domain protein
A4U85_RS18325	COG2186	Transcriptional regulator
A4U85_RS18335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4U85_RS18340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4U85_RS18355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4U85_RS18360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4U85_RS18385	COG0438	transferase activity, transferring glycosyl groups
A4U85_RS18415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A4U85_RS18420	COG1596	polysaccharide export
A4U85_RS18445	COG0728	peptidoglycan biosynthetic process
A4U85_RS18450	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4U85_RS18560	COG2184	nucleotidyltransferase activity
A4U85_RS18585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4U85_RS18625	COG0798	PFAM Bile acid sodium symporter
A4U85_RS18660	COG4691	Plasmid stability protein
A4U85_RS18750	COG0546	phosphoglycolate phosphatase activity
A4U85_RS18755	COG1028	Short-chain dehydrogenase reductase Sdr
A4U85_RS18775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U85_RS18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4U85_RS18785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4U85_RS18790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4U85_RS18795	COG1116	anion transmembrane transporter activity
A4U85_RS18800	COG1309	transcriptional regulator
A4U85_RS18805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4U85_RS18815	COG0196	riboflavin kinase activity
A4U85_RS18820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4U85_RS18830	COG1047	Peptidyl-prolyl cis-trans
A4U85_RS18870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4U85_RS18875	COG0657	acetylesterase activity
A4U85_RS18895	COG0583	DNA-binding transcription factor activity
A4U85_RS18925	COG2951	lytic endotransglycosylase activity
A4U85_RS18930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4U85_RS18950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4U85_RS18960	COG0671	phosphoesterase, PA-phosphatase related
A4U85_RS18965	COG0861	Integral membrane protein TerC family
A4U85_RS18975	COG0754	glutathionylspermidine amidase activity
A4U85_RS18985	COG0402	S-adenosylhomocysteine deaminase activity
A4U85_RS19000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4U85_RS19005	COG1230	cation diffusion facilitator family transporter
A4U85_RS19020	COG0706	membrane insertase activity
A4U85_RS19045	COG1764	response to oxidative stress
A4U85_RS19050	COG1846	Transcriptional regulator
A4U85_RS19085	COG4683	PFAM Phage derived protein Gp49-like (DUF891)