locus-tag	class	description
ACIAD_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACIAD_RS00010	COG0592	DNA-directed DNA polymerase activity
ACIAD_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIAD_RS00020	COG0187	DNA topoisomerase II activity
ACIAD_RS00030	COG0488	(ABC) transporter
ACIAD_RS00045	COG0316	Belongs to the HesB IscA family
ACIAD_RS00050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ACIAD_RS00055	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACIAD_RS00065	COG0737	Belongs to the 5'-nucleotidase family
ACIAD_RS00110	COG1047	Peptidyl-prolyl cis-trans
ACIAD_RS00115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACIAD_RS00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACIAD_RS00125	COG0196	riboflavin kinase activity
ACIAD_RS00135	COG0596	Alpha beta hydrolase
ACIAD_RS00140	COG1309	transcriptional regulator
ACIAD_RS00145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS00150	COG1335	isochorismatase
ACIAD_RS00155	COG0251	oxidation-reduction process
ACIAD_RS00160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS00165	COG2233	PERMEase
ACIAD_RS00175	COG1116	anion transmembrane transporter activity
ACIAD_RS00180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD_RS00185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS00190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD_RS00195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD_RS00200	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACIAD_RS00200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIAD_RS00215	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS00220	COG0546	phosphoglycolate phosphatase activity
ACIAD_RS00225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACIAD_RS00245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD_RS00245	COG1017	nitric oxide dioxygenase activity
ACIAD_RS00255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACIAD_RS00300	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACIAD_RS00335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ACIAD_RS00355	COG1088	dTDP-glucose 4,6-dehydratase activity
ACIAD_RS00360	COG1091	dTDP-4-dehydrorhamnose reductase activity
ACIAD_RS00375	COG0438	transferase activity, transferring glycosyl groups
ACIAD_RS00405	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACIAD_RS00410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACIAD_RS00425	COG0438	transferase activity, transferring glycosyl groups
ACIAD_RS00430	COG0438	transferase activity, transferring glycosyl groups
ACIAD_RS00435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACIAD_RS00445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACIAD_RS00460	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ACIAD_RS00470	COG0166	Belongs to the GPI family
ACIAD_RS00475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIAD_RS00480	COG3307	-O-antigen
ACIAD_RS00485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIAD_RS00490	COG0583	DNA-binding transcription factor activity
ACIAD_RS00495	COG1620	l-lactate permease
ACIAD_RS00500	COG2186	Transcriptional regulator
ACIAD_RS00505	COG1304	FMN binding
ACIAD_RS00510	COG0277	FAD linked oxidase domain protein
ACIAD_RS00525	COG1448	Aminotransferase
ACIAD_RS00535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD_RS00545	COG0251	oxidation-reduction process
ACIAD_RS00550	COG1113	amino acid transport
ACIAD_RS00560	COG3121	Chaperone
ACIAD_RS00565	COG3188	usher protein
ACIAD_RS00575	COG3121	Chaperone
ACIAD_RS00590	COG2721	sulfolactate sulfo-lyase activity
ACIAD_RS00595	COG2271	Major facilitator Superfamily
ACIAD_RS00600	COG4948	Mandelate Racemase Muconate Lactonizing
ACIAD_RS00610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIAD_RS00615	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS00620	COG2186	Transcriptional regulator
ACIAD_RS00625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD_RS00630	COG1609	Transcriptional regulator
ACIAD_RS00635	COG2233	PERMEase
ACIAD_RS00640	COG0402	S-adenosylhomocysteine deaminase activity
ACIAD_RS00665	COG0271	Belongs to the BolA IbaG family
ACIAD_RS00675	COG1192	Involved in chromosome partitioning
ACIAD_RS00690	COG0586	Pfam SNARE associated Golgi protein
ACIAD_RS00695	COG2259	Doxx family
ACIAD_RS00700	COG3111	PFAM Bacterial OB fold (BOF) protein
ACIAD_RS00705	COG0519	Catalyzes the synthesis of GMP from XMP
ACIAD_RS00705	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACIAD_RS00765	COG0018	arginyl-trna synthetase
ACIAD_RS00775	COG0281	malic enzyme
ACIAD_RS00785	COG1388	LysM domain
ACIAD_RS00785	COG3409	Peptidoglycan-binding domain 1 protein
ACIAD_RS00785	COG5632	N-Acetylmuramoyl-L-alanine amidase
ACIAD_RS00800	COG2837	iron assimilation
ACIAD_RS00805	COG1280	lysine exporter protein (LysE YggA)
ACIAD_RS00810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACIAD_RS00815	COG1121	(ABC) transporter
ACIAD_RS00835	COG0356	it plays a direct role in the translocation of protons across the membrane
ACIAD_RS00845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACIAD_RS00850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACIAD_RS00855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACIAD_RS00860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACIAD_RS00865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACIAD_RS00870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACIAD_RS00895	COG0386	Belongs to the glutathione peroxidase family
ACIAD_RS00910	COG1309	transcriptional regulator
ACIAD_RS00915	COG0697	spore germination
ACIAD_RS00955	COG3845	ABC transporter
ACIAD_RS00960	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACIAD_RS00965	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACIAD_RS00970	COG0009	L-threonylcarbamoyladenylate synthase
ACIAD_RS00975	COG0758	DNA mediated transformation
ACIAD_RS00980	COG1652	LysM domain
ACIAD_RS01010	COG1309	transcriptional regulator
ACIAD_RS01060	COG0477	Major facilitator Superfamily
ACIAD_RS01065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACIAD_RS01070	COG3757	hydrolase, family 25
ACIAD_RS01085	COG1253	flavin adenine dinucleotide binding
ACIAD_RS01095	COG2860	membrane
ACIAD_RS01100	COG0477	Major facilitator Superfamily
ACIAD_RS01110	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD_RS01125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ACIAD_RS01140	COG0606	chelatase, subunit chli
ACIAD_RS01150	COG0347	Belongs to the P(II) protein family
ACIAD_RS01155	COG0004	ammonium transporteR
ACIAD_RS01160	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACIAD_RS01165	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIAD_RS01165	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACIAD_RS01195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACIAD_RS01205	COG0795	lipopolysaccharide-transporting ATPase activity
ACIAD_RS01210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ACIAD_RS01215	COG0793	Belongs to the peptidase S41A family
ACIAD_RS01230	COG2197	response regulator
ACIAD_RS01240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ACIAD_RS01255	COG4974	Belongs to the 'phage' integrase family
ACIAD_RS01275	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACIAD_RS01280	COG0772	Belongs to the SEDS family
ACIAD_RS01285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD_RS01290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ACIAD_RS01300	COG0494	nUDIX hydrolase
ACIAD_RS01305	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACIAD_RS01310	COG1538	Outer membrane efflux protein
ACIAD_RS01320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACIAD_RS01325	COG0165	Argininosuccinate lyase
ACIAD_RS01330	COG3275	phosphorelay sensor kinase activity
ACIAD_RS01340	COG0181	hydroxymethylbilane synthase activity
ACIAD_RS01360	COG0824	Thioesterase
ACIAD_RS01420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIAD_RS01440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACIAD_RS01445	COG0081	regulation of translation
ACIAD_RS01450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACIAD_RS01455	COG0222	ribosome binding
ACIAD_RS01460	COG0085	RNA polymerase activity
ACIAD_RS01465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACIAD_RS01485	COG2056	Na+-H+ antiporter family
ACIAD_RS01500	COG0326	Molecular chaperone. Has ATPase activity
ACIAD_RS01510	COG1794	racemase activity, acting on amino acids and derivatives
ACIAD_RS01515	COG1301	dicarboxylic acid transport
ACIAD_RS01530	COG0583	DNA-binding transcription factor activity
ACIAD_RS01550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ACIAD_RS01565	COG0183	Belongs to the thiolase family
ACIAD_RS01570	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACIAD_RS01570	COG1024	Enoyl-CoA hydratase
ACIAD_RS01590	COG0322	excinuclease ABC activity
ACIAD_RS01600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIAD_RS01605	COG2169	Transcriptional regulator
ACIAD_RS01605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIAD_RS01630	COG1566	PFAM secretion protein HlyD family protein
ACIAD_RS01635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACIAD_RS01640	COG1678	Uncharacterized ACR, COG1678
ACIAD_RS01645	COG0497	DNA recombination
ACIAD_RS01655	COG3123	guanosine phosphorylase activity
ACIAD_RS01660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIAD_RS01670	COG0237	dephospho-CoA kinase activity
ACIAD_RS01690	COG0149	triose-phosphate isomerase activity
ACIAD_RS01715	COG0779	Required for maturation of 30S ribosomal subunits
ACIAD_RS01720	COG0195	Participates in both transcription termination and antitermination
ACIAD_RS01725	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACIAD_RS01730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACIAD_RS01735	COG1320	monovalent cation:proton antiporter activity
ACIAD_RS01740	COG2212	antiporter activity
ACIAD_RS01745	COG1863	multisubunit Na H antiporter MnhE subunit
ACIAD_RS01750	COG0651	ATP synthesis coupled electron transport
ACIAD_RS01755	COG1006	Multisubunit Na H antiporter MnhC subunit
ACIAD_RS01760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIAD_RS01760	COG2111	Na H antiporter
ACIAD_RS01765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ACIAD_RS01775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACIAD_RS01785	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIAD_RS01795	COG2226	methyltransferase
ACIAD_RS01810	COG3121	Chaperone
ACIAD_RS01815	COG3188	usher protein
ACIAD_RS01840	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ACIAD_RS01845	COG1074	ATP-dependent DNA helicase activity
ACIAD_RS01850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIAD_RS01855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIAD_RS01860	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACIAD_RS01865	COG1185	polyribonucleotide nucleotidyltransferase activity
ACIAD_RS01870	COG0598	Magnesium transport protein CorA
ACIAD_RS01875	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACIAD_RS01880	COG0789	Transcriptional regulator
ACIAD_RS01890	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACIAD_RS01900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACIAD_RS01920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACIAD_RS01925	COG4535	Mg2 and Co2 transporter CorC
ACIAD_RS01930	COG0425	Belongs to the sulfur carrier protein TusA family
ACIAD_RS01935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACIAD_RS01940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
ACIAD_RS01950	COG0493	'glutamate synthase
ACIAD_RS01950	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIAD_RS01965	COG0254	rRNA binding
ACIAD_RS01970	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACIAD_RS01985	COG0534	Mate efflux family protein
ACIAD_RS01995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACIAD_RS02005	COG0583	DNA-binding transcription factor activity
ACIAD_RS02010	COG0450	alkyl hydroperoxide reductase
ACIAD_RS02025	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD_RS02030	COG1530	ribonuclease E activity
ACIAD_RS02040	COG0546	phosphoglycolate phosphatase activity
ACIAD_RS02050	COG0625	glutathione transferase activity
ACIAD_RS02060	COG0583	DNA-binding transcription factor activity
ACIAD_RS02075	COG0753	catalase activity
ACIAD_RS02080	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS02090	COG0494	nUDIX hydrolase
ACIAD_RS02115	COG0583	DNA-binding transcription factor activity
ACIAD_RS02125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACIAD_RS02135	COG0066	3-isopropylmalate dehydratase activity
ACIAD_RS02145	COG0473	3-isopropylmalate dehydrogenase activity
ACIAD_RS02155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACIAD_RS02165	COG0101	tRNA pseudouridine synthase activity
ACIAD_RS02190	COG1301	dicarboxylic acid transport
ACIAD_RS02200	COG1560	Kdo2-lipid A biosynthetic process
ACIAD_RS02205	COG0405	Gamma-glutamyltransferase
ACIAD_RS02210	COG1280	lysine exporter protein (LysE YggA)
ACIAD_RS02215	COG0488	(ABC) transporter
ACIAD_RS02220	COG2900	Belongs to the SlyX family
ACIAD_RS02245	COG0210	DNA helicase
ACIAD_RS02270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIAD_RS02270	COG4651	solute:proton antiporter activity
ACIAD_RS02295	COG0788	formyltetrahydrofolate deformylase activity
ACIAD_RS02335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ACIAD_RS02350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACIAD_RS02370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIAD_RS02385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACIAD_RS02395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD_RS02395	COG2813	Specifically methylates the guanine in position
ACIAD_RS02400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD_RS02405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIAD_RS02410	COG3128	pkhd-type hydroxylase
ACIAD_RS02415	COG4774	siderophore transport
ACIAD_RS02420	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACIAD_RS02425	COG0740	serine-type endopeptidase activity
ACIAD_RS02430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACIAD_RS02445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
ACIAD_RS02445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
ACIAD_RS02455	COG0280	phosphate acetyltransferase
ACIAD_RS02455	COG0857	belongs to the CobB CobQ family
ACIAD_RS02460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACIAD_RS02470	COG0800	Aldolase
ACIAD_RS02480	COG3265	gluconokinase activity
ACIAD_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS02490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACIAD_RS02495	COG2267	carboxylic ester hydrolase activity
ACIAD_RS02510	COG0793	Belongs to the peptidase S41A family
ACIAD_RS02530	COG0105	UTP biosynthetic process
ACIAD_RS02535	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACIAD_RS02545	COG1426	Protein conserved in bacteria
ACIAD_RS02550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ACIAD_RS02555	COG0124	histidyl-tRNA synthetase
ACIAD_RS02590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIAD_RS02600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIAD_RS02615	COG2986	histidine ammonia-lyase
ACIAD_RS02645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIAD_RS02655	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS02660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACIAD_RS02690	COG1862	Preprotein translocase
ACIAD_RS02695	COG0343	queuine tRNA-ribosyltransferase activity
ACIAD_RS02700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACIAD_RS02715	COG5002	protein histidine kinase activity
ACIAD_RS02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACIAD_RS02740	COG0726	polysaccharide deacetylase
ACIAD_RS02745	COG0463	Glycosyl transferase, family 2
ACIAD_RS02750	COG0438	transferase activity, transferring glycosyl groups
ACIAD_RS02785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACIAD_RS02840	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS02845	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS02855	COG2205	protein histidine kinase activity
ACIAD_RS02860	COG0745	RESPONSE REGULATOR receiver
ACIAD_RS02865	COG2315	Protein conserved in bacteria
ACIAD_RS02890	COG2096	Adenosyltransferase
ACIAD_RS02895	COG4206	TonB-dependent receptor
ACIAD_RS02930	COG0159	tryptophan synthase activity
ACIAD_RS02935	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACIAD_RS02940	COG0285	dihydrofolate synthase activity
ACIAD_RS02955	COG0450	alkyl hydroperoxide reductase
ACIAD_RS02960	COG0653	protein targeting
ACIAD_RS02970	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACIAD_RS02975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ACIAD_RS03005	COG2199	diguanylate cyclase activity
ACIAD_RS03055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACIAD_RS03060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACIAD_RS03065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACIAD_RS03070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACIAD_RS03115	COG0494	nUDIX hydrolase
ACIAD_RS03125	COG1214	PFAM Peptidase M22, glycoprotease
ACIAD_RS03130	COG1968	undecaprenyl-diphosphatase activity
ACIAD_RS03135	COG0742	ribosomal rna small subunit methyltransferase
ACIAD_RS03155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACIAD_RS03165	COG2132	Multicopper oxidase
ACIAD_RS03185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACIAD_RS03195	COG0183	Belongs to the thiolase family
ACIAD_RS03210	COG0833	amino acid
ACIAD_RS03215	COG2813	Specifically methylates the guanine in position
ACIAD_RS03220	COG2233	PERMEase
ACIAD_RS03225	COG1217	gtp-binding protein TYPA
ACIAD_RS03230	COG1970	mechanosensitive ion channel activity
ACIAD_RS03240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD_RS03245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACIAD_RS03250	COG4772	TonB-dependent receptor
ACIAD_RS03255	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS03280	COG0564	pseudouridine synthase activity
ACIAD_RS03300	COG2824	Alkylphosphonate utilization operon protein PhnA
ACIAD_RS03310	COG3422	double-strand break repair
ACIAD_RS03315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ACIAD_RS03325	COG0745	RESPONSE REGULATOR receiver
ACIAD_RS03330	COG2205	protein histidine kinase activity
ACIAD_RS03340	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD_RS03345	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD_RS03350	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD_RS03350	COG0649	NAD binding
ACIAD_RS03360	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ACIAD_RS03370	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACIAD_RS03375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD_RS03385	COG0713	ATP synthesis coupled electron transport
ACIAD_RS03390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACIAD_RS03395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACIAD_RS03405	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACIAD_RS03415	COG0583	DNA-binding transcription factor activity
ACIAD_RS03435	COG0668	transmembrane transport
ACIAD_RS03445	COG2081	HI0933 family
ACIAD_RS03450	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ACIAD_RS03475	COG2226	methyltransferase
ACIAD_RS03480	COG1280	lysine exporter protein (LysE YggA)
ACIAD_RS03495	COG2233	PERMEase
ACIAD_RS03520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIAD_RS03520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACIAD_RS03535	COG0489	protein tyrosine kinase activity
ACIAD_RS03540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACIAD_RS03555	COG0717	Belongs to the dCTP deaminase family
ACIAD_RS03585	COG0442	prolyl-tRNA aminoacylation
ACIAD_RS03620	COG0840	transmembrane signaling receptor activity
ACIAD_RS03625	COG0643	Histidine kinase
ACIAD_RS03625	COG2198	Histidine kinase
ACIAD_RS03630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACIAD_RS03645	COG2832	Protein of unknown function (DUF454)
ACIAD_RS03650	COG1376	ErfK ybiS ycfS ynhG family protein
ACIAD_RS03695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACIAD_RS03705	COG1289	transmembrane transporter activity
ACIAD_RS03710	COG2814	Major facilitator Superfamily
ACIAD_RS03720	COG0786	glutamate:sodium symporter activity
ACIAD_RS03725	COG1115	amino acid carrier protein
ACIAD_RS03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIAD_RS03740	COG0693	protein deglycase activity
ACIAD_RS03745	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
ACIAD_RS03805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIAD_RS03810	COG0154	amidase activity
ACIAD_RS03815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACIAD_RS03820	COG1077	Cell shape determining protein MreB Mrl
ACIAD_RS03825	COG1792	Involved in formation and maintenance of cell shape
ACIAD_RS03830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ACIAD_RS03835	COG0424	maF-like protein
ACIAD_RS03840	COG1530	ribonuclease E activity
ACIAD_RS03845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD_RS03855	COG0560	Phosphoserine phosphatase
ACIAD_RS03865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIAD_RS03875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACIAD_RS03880	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACIAD_RS03890	COG0730	response to heat
ACIAD_RS03900	COG1196	nuclear chromosome segregation
ACIAD_RS03910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACIAD_RS03940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIAD_RS03945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD_RS03945	COG0596	Alpha beta hydrolase
ACIAD_RS03945	COG2226	methyltransferase
ACIAD_RS03960	COG4106	trans-aconitate 2-methyltransferase activity
ACIAD_RS03980	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACIAD_RS03985	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACIAD_RS03995	COG0009	L-threonylcarbamoyladenylate synthase
ACIAD_RS04000	COG3101	peptidyl-lysine hydroxylation
ACIAD_RS04005	COG1399	metal-binding, possibly nucleic acid-binding protein
ACIAD_RS04010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACIAD_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS04025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACIAD_RS04030	COG1652	LysM domain
ACIAD_RS04040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACIAD_RS04040	COG0351	phosphomethylpyrimidine kinase
ACIAD_RS04040	COG0352	thiamine-phosphate diphosphorylase activity
ACIAD_RS04050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIAD_RS04050	COG2755	lipolytic protein G-D-S-L family
ACIAD_RS04055	COG1981	membrane
ACIAD_RS04070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACIAD_RS04075	COG0049	tRNA binding
ACIAD_RS04080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACIAD_RS04085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACIAD_RS04100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACIAD_RS04105	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACIAD_RS04110	COG0492	ferredoxin-NADP+ reductase activity
ACIAD_RS04115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ACIAD_RS04115	COG1674	ftsk spoiiie
ACIAD_RS04125	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACIAD_RS04135	COG0850	regulation of cytokinetic process
ACIAD_RS04145	COG0204	Acyl-transferase
ACIAD_RS04150	COG2885	chlorophyll binding
ACIAD_RS04155	COG0210	DNA helicase
ACIAD_RS04160	COG0756	dUTP diphosphatase activity
ACIAD_RS04170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACIAD_RS04180	COG0121	glutamine amidotransferase
ACIAD_RS04190	COG2914	Belongs to the UPF0125 (RnfH) family
ACIAD_RS04195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIAD_RS04200	COG0735	belongs to the Fur family
ACIAD_RS04220	COG1968	undecaprenyl-diphosphatase activity
ACIAD_RS04235	COG0420	3'-5' exonuclease activity
ACIAD_RS04255	COG1090	epimerase
ACIAD_RS04270	COG2050	protein possibly involved in aromatic compounds catabolism
ACIAD_RS04275	COG1566	PFAM secretion protein HlyD family protein
ACIAD_RS04280	COG2814	Major facilitator Superfamily
ACIAD_RS04285	COG0405	Gamma-glutamyltransferase
ACIAD_RS04290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ACIAD_RS04305	COG3220	belongs to the UPF0276 family
ACIAD_RS04315	COG1595	DNA-templated transcription, initiation
ACIAD_RS04335	COG2831	hemolysin activation secretion protein
ACIAD_RS04340	COG3210	domain, Protein
ACIAD_RS04425	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS04445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIAD_RS04460	COG0583	DNA-binding transcription factor activity
ACIAD_RS04470	COG1120	ATPase activity
ACIAD_RS04475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACIAD_RS04480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACIAD_RS04510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD_RS04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS04535	COG1414	Transcriptional regulator
ACIAD_RS04540	COG2146	nitrite reductase [NAD(P)H] activity
ACIAD_RS04565	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD_RS04570	COG2271	Major facilitator Superfamily
ACIAD_RS04580	COG2267	carboxylic ester hydrolase activity
ACIAD_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS04590	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ACIAD_RS04595	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS04600	COG0028	Belongs to the TPP enzyme family
ACIAD_RS04640	COG0579	oxidoreductase
ACIAD_RS04645	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACIAD_RS04650	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS04655	COG1309	transcriptional regulator
ACIAD_RS04660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD_RS04665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD_RS04680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIAD_RS04685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACIAD_RS04690	COG0022	dehydrogenase e1 component
ACIAD_RS04695	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIAD_RS04700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD_RS04705	COG1063	alcohol dehydrogenase
ACIAD_RS04715	COG1607	acyl-coa hydrolase
ACIAD_RS04725	COG0523	cobalamin synthesis protein
ACIAD_RS04735	COG4681	YaeQ
ACIAD_RS04745	COG0726	polysaccharide deacetylase
ACIAD_RS04745	COG1649	PFAM Uncharacterised BCR, COG1649
ACIAD_RS04750	COG1215	transferase activity, transferring glycosyl groups
ACIAD_RS04775	COG0400	carboxylic ester hydrolase activity
ACIAD_RS04790	COG0561	phosphatase activity
ACIAD_RS04795	COG0242	peptide deformylase activity
ACIAD_RS04800	COG2066	Belongs to the glutaminase family
ACIAD_RS04810	COG2223	nitrite transmembrane transporter activity
ACIAD_RS04825	COG0306	phosphate transporter
ACIAD_RS04830	COG3048	D-serine ammonia-lyase activity
ACIAD_RS04845	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ACIAD_RS04855	COG4771	TonB-dependent receptor
ACIAD_RS04865	COG0288	reversible hydration of carbon dioxide
ACIAD_RS04875	COG4181	ATPase activity
ACIAD_RS04880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACIAD_RS04885	COG0705	Rhomboid family
ACIAD_RS04885	COG0457	Tetratricopeptide repeat
ACIAD_RS04890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACIAD_RS04900	COG0583	DNA-binding transcription factor activity
ACIAD_RS04910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD_RS04915	COG1773	rubredoxin
ACIAD_RS04925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACIAD_RS04930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIAD_RS04935	COG1492	cobalamin metabolic process
ACIAD_RS04940	COG0175	sulfate reduction
ACIAD_RS04950	COG2851	Citrate transporter
ACIAD_RS04975	COG1253	flavin adenine dinucleotide binding
ACIAD_RS05000	COG0829	nickel cation binding
ACIAD_RS05005	COG0831	urea catabolic process
ACIAD_RS05010	COG0832	Belongs to the urease beta subunit family
ACIAD_RS05015	COG0804	urea catabolic process
ACIAD_RS05025	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
ACIAD_RS05030	COG0830	nickel cation binding
ACIAD_RS05035	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
ACIAD_RS05055	COG0742	ribosomal rna small subunit methyltransferase
ACIAD_RS05060	COG0768	penicillin binding
ACIAD_RS05075	COG0563	adenylate kinase activity
ACIAD_RS05080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACIAD_RS05085	COG2878	Part of a membrane complex involved in electron transport
ACIAD_RS05090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIAD_RS05100	COG3384	dioxygenase
ACIAD_RS05105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACIAD_RS05115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACIAD_RS05130	COG0463	Glycosyl transferase, family 2
ACIAD_RS05165	COG0006	proline dipeptidase activity
ACIAD_RS05170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS05175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS05195	COG0792	nuclease activity
ACIAD_RS05225	COG0741	lytic transglycosylase activity
ACIAD_RS05225	COG0741	lytic transglycosylase activity
ACIAD_RS05225	COG1388	LysM domain
ACIAD_RS05225	COG1388	LysM domain
ACIAD_RS05230	COG4166	transmembrane transport
ACIAD_RS05235	COG4174	ABC transporter (Permease)
ACIAD_RS05240	COG4239	(ABC) transporter, permease
ACIAD_RS05245	COG4172	Belongs to the ABC transporter superfamily
ACIAD_RS05275	COG0833	amino acid
ACIAD_RS05290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACIAD_RS05295	COG0418	dihydroorotase activity
ACIAD_RS05305	COG0583	DNA-binding transcription factor activity
ACIAD_RS05310	COG0697	spore germination
ACIAD_RS05315	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD_RS05315	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS05340	COG1538	Outer membrane efflux protein
ACIAD_RS05345	COG1595	DNA-templated transcription, initiation
ACIAD_RS05355	COG4774	siderophore transport
ACIAD_RS05365	COG2771	luxR family
ACIAD_RS05375	COG1113	amino acid transport
ACIAD_RS05420	COG1215	transferase activity, transferring glycosyl groups
ACIAD_RS05435	COG0415	Belongs to the DNA photolyase family
ACIAD_RS05445	COG1686	Belongs to the peptidase S11 family
ACIAD_RS05460	COG2351	hydroxyisourate hydrolase activity
ACIAD_RS05475	COG1823	symporter activity
ACIAD_RS05485	COG0038	chloride channel
ACIAD_RS05490	COG0612	Peptidase, M16
ACIAD_RS05525	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACIAD_RS05530	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ACIAD_RS05545	COG0783	Belongs to the Dps family
ACIAD_RS05555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD_RS05570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD_RS05575	COG0076	glutamate decarboxylase activity
ACIAD_RS05580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ACIAD_RS05585	COG0573	inorganic phosphate transmembrane transporter activity
ACIAD_RS05595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACIAD_RS05600	COG0616	signal peptide processing
ACIAD_RS05615	COG2915	High frequency lysogenization protein hflD homolog
ACIAD_RS05620	COG0482	sulfurtransferase activity
ACIAD_RS05635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ACIAD_RS05640	COG1686	Belongs to the peptidase S11 family
ACIAD_RS05650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ACIAD_RS05660	COG0583	DNA-binding transcription factor activity
ACIAD_RS05665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIAD_RS05680	COG3634	alkyl hydroperoxide reductase activity
ACIAD_RS05700	COG0589	response to stress
ACIAD_RS05715	COG0659	secondary active sulfate transmembrane transporter activity
ACIAD_RS05725	COG2252	PERMEase
ACIAD_RS05730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACIAD_RS05735	COG3038	cytochrome b561
ACIAD_RS05745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACIAD_RS05760	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ACIAD_RS05765	COG0527	aspartate kinase activity
ACIAD_RS05770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACIAD_RS05780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACIAD_RS05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACIAD_RS05800	COG0667	Aldo Keto reductase
ACIAD_RS05810	COG1765	OsmC-like protein
ACIAD_RS05825	COG0129	dihydroxy-acid dehydratase activity
ACIAD_RS05835	COG0116	Belongs to the methyltransferase superfamily
ACIAD_RS05835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ACIAD_RS05845	COG0540	Belongs to the ATCase OTCase family
ACIAD_RS05865	COG4106	trans-aconitate 2-methyltransferase activity
ACIAD_RS05870	COG0531	amino acid
ACIAD_RS05880	COG0189	ligase activity
ACIAD_RS05880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIAD_RS05905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACIAD_RS05910	COG3138	arginine N-succinyltransferase
ACIAD_RS05915	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS05920	COG3724	N-succinylarginine dihydrolase activity
ACIAD_RS05925	COG2988	succinylglutamate desuccinylase activity
ACIAD_RS05940	COG0235	Class ii aldolase
ACIAD_RS05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACIAD_RS05965	COG1126	abc transporter atp-binding protein
ACIAD_RS05980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD_RS05985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACIAD_RS06005	COG2022	thiamine diphosphate biosynthetic process
ACIAD_RS06015	COG2363	Small membrane protein
ACIAD_RS06035	COG0513	Belongs to the DEAD box helicase family
ACIAD_RS06050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACIAD_RS06070	COG0167	dihydroorotate dehydrogenase activity
ACIAD_RS06100	COG4783	chaperone-mediated protein folding
ACIAD_RS06120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACIAD_RS06140	COG2815	serine threonine protein kinase
ACIAD_RS06140	COG0515	serine threonine protein kinase
ACIAD_RS06160	COG1301	dicarboxylic acid transport
ACIAD_RS06180	COG1113	amino acid transport
ACIAD_RS06185	COG1522	sequence-specific DNA binding
ACIAD_RS06205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACIAD_RS06210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACIAD_RS06215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIAD_RS06220	COG1585	Membrane protein implicated in regulation of membrane protease activity
ACIAD_RS06230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIAD_RS06245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACIAD_RS06250	COG0569	domain protein
ACIAD_RS06255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACIAD_RS06260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACIAD_RS06270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACIAD_RS06280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACIAD_RS06285	COG0542	response to heat
ACIAD_RS06290	COG1742	UPF0060 membrane protein
ACIAD_RS06295	COG0657	acetylesterase activity
ACIAD_RS06295	COG2755	lipolytic protein G-D-S-L family
ACIAD_RS06300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACIAD_RS06315	COG3852	Histidine kinase
ACIAD_RS06320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIAD_RS06325	COG0528	UMP kinase activity
ACIAD_RS06330	COG0233	cytoplasmic translational termination
ACIAD_RS06335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACIAD_RS06340	COG0575	Belongs to the CDS family
ACIAD_RS06345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACIAD_RS06355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACIAD_RS06365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD_RS06370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACIAD_RS06375	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD_RS06385	COG2137	regulation of response to DNA damage stimulus
ACIAD_RS06390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACIAD_RS06395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ACIAD_RS06410	COG0268	Binds directly to 16S ribosomal RNA
ACIAD_RS06420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACIAD_RS06440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACIAD_RS06455	COG0633	Ferredoxin
ACIAD_RS06460	COG0443	Heat shock 70 kDa protein
ACIAD_RS06465	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACIAD_RS06470	COG0316	Belongs to the HesB IscA family
ACIAD_RS06475	COG0822	iron-sulfur transferase activity
ACIAD_RS06500	COG0776	regulation of translation
ACIAD_RS06505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD_RS06510	COG2207	Transcriptional regulator
ACIAD_RS06515	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACIAD_RS06520	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS06545	COG0531	amino acid
ACIAD_RS06550	COG2040	homocysteine
ACIAD_RS06555	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACIAD_RS06565	COG0642	Histidine kinase
ACIAD_RS06570	COG0745	RESPONSE REGULATOR receiver
ACIAD_RS06575	COG2194	sulfuric ester hydrolase activity
ACIAD_RS06600	COG0657	acetylesterase activity
ACIAD_RS06615	COG3284	Transcriptional regulator
ACIAD_RS06625	COG2814	Major facilitator Superfamily
ACIAD_RS06630	COG0583	DNA-binding transcription factor activity
ACIAD_RS06635	COG4638	Rieske (2fe-2S)
ACIAD_RS06640	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD_RS06645	COG0543	2 iron, 2 sulfur cluster binding
ACIAD_RS06645	COG0633	Ferredoxin
ACIAD_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS06655	COG3135	benzoate transporter
ACIAD_RS06660	COG3485	protocatechuate 3,4-dioxygenase
ACIAD_RS06665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIAD_RS06670	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ACIAD_RS06675	COG0583	DNA-binding transcription factor activity
ACIAD_RS06680	COG4948	Mandelate Racemase Muconate Lactonizing
ACIAD_RS06685	COG4829	muconolactone delta-isomerase
ACIAD_RS06690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACIAD_RS06695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD_RS06700	COG0183	Belongs to the thiolase family
ACIAD_RS06705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACIAD_RS06710	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD_RS06715	COG1733	regulation of RNA biosynthetic process
ACIAD_RS06720	COG0604	alcohol dehydrogenase
ACIAD_RS06740	COG0531	amino acid
ACIAD_RS06755	COG3781	membrane
ACIAD_RS06760	COG2186	Transcriptional regulator
ACIAD_RS06765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD_RS06770	COG1116	anion transmembrane transporter activity
ACIAD_RS06775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD_RS06785	COG1595	DNA-templated transcription, initiation
ACIAD_RS06835	COG0215	cysteine-tRNA ligase activity
ACIAD_RS06840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACIAD_RS06840	COG0517	IMP dehydrogenase activity
ACIAD_RS06845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACIAD_RS06855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
ACIAD_RS06860	COG1137	ATPase activity
ACIAD_RS06870	COG2274	protein secretion by the type I secretion system
ACIAD_RS06900	COG4122	O-methyltransferase activity
ACIAD_RS06910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ACIAD_RS06920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACIAD_RS06950	COG0601	transmembrane transport
ACIAD_RS06955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACIAD_RS06975	COG1132	(ABC) transporter
ACIAD_RS06980	COG1132	(ABC) transporter
ACIAD_RS06985	COG4206	TonB-dependent receptor
ACIAD_RS06995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS07010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACIAD_RS07025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD_RS07030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD_RS07035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD_RS07040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS07060	COG0747	negative chemotaxis
ACIAD_RS07075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS07085	COG1053	succinate dehydrogenase
ACIAD_RS07090	COG0583	DNA-binding transcription factor activity
ACIAD_RS07155	COG1846	Transcriptional regulator
ACIAD_RS07160	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS07190	COG1024	Enoyl-CoA hydratase
ACIAD_RS07195	COG0183	Belongs to the thiolase family
ACIAD_RS07205	COG1024	Enoyl-CoA hydratase
ACIAD_RS07210	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD_RS07230	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS07255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ACIAD_RS07260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD_RS07265	COG1045	serine acetyltransferase
ACIAD_RS07275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACIAD_RS07305	COG2175	clavaminate synthase activity
ACIAD_RS07320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS07325	COG0667	Aldo Keto reductase
ACIAD_RS07340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD_RS07345	COG2175	clavaminate synthase activity
ACIAD_RS07355	COG0583	DNA-binding transcription factor activity
ACIAD_RS07370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD_RS07375	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07380	COG1024	Enoyl-CoA hydratase
ACIAD_RS07395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD_RS07400	COG0183	Belongs to the thiolase family
ACIAD_RS07405	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07450	COG0730	response to heat
ACIAD_RS07475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIAD_RS07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACIAD_RS07490	COG0642	Histidine kinase
ACIAD_RS07515	COG1396	sequence-specific DNA binding
ACIAD_RS07535	COG1968	undecaprenyl-diphosphatase activity
ACIAD_RS07550	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIAD_RS07555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACIAD_RS07555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACIAD_RS07555	COG0506	proline dehydrogenase activity
ACIAD_RS07565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIAD_RS07570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACIAD_RS07575	COG0477	Major facilitator Superfamily
ACIAD_RS07580	COG0596	Alpha beta hydrolase
ACIAD_RS07590	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS07590	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD_RS07600	COG0583	DNA-binding transcription factor activity
ACIAD_RS07605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD_RS07615	COG0583	DNA-binding transcription factor activity
ACIAD_RS07620	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ACIAD_RS07665	COG4589	Belongs to the CDS family
ACIAD_RS07680	COG0671	phosphoesterase, PA-phosphatase related
ACIAD_RS07680	COG2453	phosphatase
ACIAD_RS07685	COG2267	carboxylic ester hydrolase activity
ACIAD_RS07690	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACIAD_RS07705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACIAD_RS07715	COG1380	Effector of murein hydrolase LrgA
ACIAD_RS07720	COG0583	DNA-binding transcription factor activity
ACIAD_RS07745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACIAD_RS07745	COG0644	oxidoreductase
ACIAD_RS07750	COG2814	Major facilitator Superfamily
ACIAD_RS07765	COG2814	Major facilitator Superfamily
ACIAD_RS07780	COG0183	Belongs to the thiolase family
ACIAD_RS07785	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACIAD_RS07790	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS07795	COG1024	Enoyl-CoA hydratase
ACIAD_RS07800	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07805	COG2814	Major facilitator Superfamily
ACIAD_RS07815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD_RS07825	COG2814	Major facilitator Superfamily
ACIAD_RS07835	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07840	COG1024	Enoyl-CoA hydratase
ACIAD_RS07845	COG1414	Transcriptional regulator
ACIAD_RS07850	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ACIAD_RS07855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACIAD_RS07860	COG0183	Belongs to the thiolase family
ACIAD_RS07865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ACIAD_RS07870	COG0596	Alpha beta hydrolase
ACIAD_RS07875	COG2271	Major facilitator Superfamily
ACIAD_RS07880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIAD_RS07885	COG3485	protocatechuate 3,4-dioxygenase
ACIAD_RS07890	COG3485	protocatechuate 3,4-dioxygenase
ACIAD_RS07895	COG0710	3-dehydroquinate dehydratase activity
ACIAD_RS07900	COG3420	alginic acid biosynthetic process
ACIAD_RS07905	COG3659	wide pore channel activity
ACIAD_RS07910	COG4993	Dehydrogenase
ACIAD_RS07920	COG1414	Transcriptional regulator
ACIAD_RS07925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS07945	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS07960	COG1024	Enoyl-CoA hydratase
ACIAD_RS07965	COG2814	Major facilitator Superfamily
ACIAD_RS07975	COG1309	transcriptional regulator
ACIAD_RS07990	COG2072	flavoprotein involved in K transport
ACIAD_RS07995	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ACIAD_RS08005	COG0439	Biotin carboxylase
ACIAD_RS08015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACIAD_RS08020	COG1469	GTP cyclohydrolase I activity
ACIAD_RS08025	COG0523	cobalamin synthesis protein
ACIAD_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS08035	COG0604	alcohol dehydrogenase
ACIAD_RS08035	COG3321	synthase
ACIAD_RS08040	COG1027	Aspartate ammonia-lyase
ACIAD_RS08045	COG0583	DNA-binding transcription factor activity
ACIAD_RS08065	COG1294	oxidase, subunit
ACIAD_RS08070	COG1271	oxidase subunit
ACIAD_RS08085	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
ACIAD_RS08090	COG3052	prosthetic group binding
ACIAD_RS08130	COG1045	serine acetyltransferase
ACIAD_RS08135	COG4774	siderophore transport
ACIAD_RS08180	COG2223	nitrite transmembrane transporter activity
ACIAD_RS08185	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ACIAD_RS08200	COG1595	DNA-templated transcription, initiation
ACIAD_RS08290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACIAD_RS08290	COG2755	lipolytic protein G-D-S-L family
ACIAD_RS08300	COG2116	formate transmembrane transporter activity
ACIAD_RS08340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS08355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACIAD_RS08370	COG2814	Major facilitator Superfamily
ACIAD_RS08375	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD_RS08395	COG1024	Enoyl-CoA hydratase
ACIAD_RS08400	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS08410	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS08425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS08430	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS08435	COG1024	Enoyl-CoA hydratase
ACIAD_RS08440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS08450	COG4628	conserved protein (DUF2132)
ACIAD_RS08455	COG2207	Transcriptional regulator
ACIAD_RS08460	COG1073	alpha beta
ACIAD_RS08465	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS08470	COG2207	Transcriptional regulator
ACIAD_RS08480	COG2207	Transcriptional regulator
ACIAD_RS08595	COG0640	Transcriptional regulator
ACIAD_RS08600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ACIAD_RS08610	COG3122	Protein conserved in bacteria
ACIAD_RS08615	COG0668	transmembrane transport
ACIAD_RS08625	COG1132	(ABC) transporter
ACIAD_RS08640	COG0509	glycine decarboxylation via glycine cleavage system
ACIAD_RS08645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACIAD_RS08650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ACIAD_RS08660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIAD_RS08685	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS08710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACIAD_RS08735	COG0697	spore germination
ACIAD_RS08740	COG0436	Aminotransferase
ACIAD_RS08745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
ACIAD_RS08750	COG4149	molybdate abc transporter
ACIAD_RS08755	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACIAD_RS08760	COG0303	'Molybdopterin
ACIAD_RS08765	COG0315	cyclic pyranopterin monophosphate synthase activity
ACIAD_RS08765	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACIAD_RS08790	COG0243	molybdopterin cofactor binding
ACIAD_RS08795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD_RS08800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD_RS08805	COG2223	nitrite transmembrane transporter activity
ACIAD_RS08815	COG1116	anion transmembrane transporter activity
ACIAD_RS08815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACIAD_RS08820	COG0243	molybdopterin cofactor binding
ACIAD_RS08825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ACIAD_RS08840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD_RS08855	COG0778	Nitroreductase
ACIAD_RS08860	COG0697	spore germination
ACIAD_RS08865	COG0191	fructose-bisphosphate aldolase activity
ACIAD_RS08875	COG0126	phosphoglycerate kinase activity
ACIAD_RS08885	COG0424	maF-like protein
ACIAD_RS08890	COG2851	Citrate transporter
ACIAD_RS08895	COG2850	peptidyl-arginine hydroxylation
ACIAD_RS08900	COG0069	glutamate synthase activity
ACIAD_RS08905	COG3829	transcription factor binding
ACIAD_RS08955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ACIAD_RS08960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACIAD_RS08965	COG1278	Cold shock
ACIAD_RS08970	COG1454	alcohol dehydrogenase
ACIAD_RS08975	COG0824	Thioesterase
ACIAD_RS09020	COG1358	cellular component organization or biogenesis
ACIAD_RS09065	COG4245	von Willebrand factor, type A
ACIAD_RS09080	COG1309	transcriptional regulator
ACIAD_RS09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ACIAD_RS09110	COG0583	DNA-binding transcription factor activity
ACIAD_RS09115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACIAD_RS09125	COG3135	benzoate transporter
ACIAD_RS09135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACIAD_RS09145	COG1714	RDD family
ACIAD_RS09150	COG0024	Methionine aminopeptidase
ACIAD_RS09165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACIAD_RS09165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACIAD_RS09170	COG1105	Belongs to the carbohydrate kinase PfkB family
ACIAD_RS09175	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ACIAD_RS09175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIAD_RS09175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ACIAD_RS09185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACIAD_RS09200	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACIAD_RS09210	COG0148	phosphopyruvate hydratase activity
ACIAD_RS09215	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACIAD_RS09220	COG0504	CTP synthase activity
ACIAD_RS09230	COG0589	response to stress
ACIAD_RS09245	COG0308	aminopeptidase N
ACIAD_RS09260	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ACIAD_RS09265	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ACIAD_RS09275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ACIAD_RS09280	COG1454	alcohol dehydrogenase
ACIAD_RS09300	COG0505	Belongs to the CarA family
ACIAD_RS09340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACIAD_RS09355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACIAD_RS09360	COG2353	YceI-like domain
ACIAD_RS09365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACIAD_RS09370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACIAD_RS09385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACIAD_RS09390	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ACIAD_RS09390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACIAD_RS09400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACIAD_RS09420	COG2193	ferroxidase activity
ACIAD_RS09435	COG0217	transcriptional regulatory protein
ACIAD_RS09450	COG1126	abc transporter atp-binding protein
ACIAD_RS09455	COG0765	amino acid transport
ACIAD_RS09460	COG0765	amino acid transport
ACIAD_RS09490	COG1464	Belongs to the NlpA lipoprotein family
ACIAD_RS09495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACIAD_RS09500	COG2011	ABC-type metal ion transport system permease component
ACIAD_RS09505	COG0012	GTP binding
ACIAD_RS09530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACIAD_RS09535	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACIAD_RS09565	COG0386	Belongs to the glutathione peroxidase family
ACIAD_RS09570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACIAD_RS09575	COG0436	Aminotransferase
ACIAD_RS09595	COG1045	serine acetyltransferase
ACIAD_RS09615	COG3706	GGDEF domain
ACIAD_RS09625	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACIAD_RS09630	COG0596	Alpha beta hydrolase
ACIAD_RS09635	COG2223	nitrite transmembrane transporter activity
ACIAD_RS09645	COG1643	Atp-dependent helicase
ACIAD_RS09650	COG0450	alkyl hydroperoxide reductase
ACIAD_RS09725	COG4264	IucA IucC family
ACIAD_RS09940	COG3561	AntA/AntB antirepressor
ACIAD_RS09955	COG3567	Phage-associated protein, HI1409 family
ACIAD_RS09960	COG5410	chromosome segregation
ACIAD_RS09985	COG3093	addiction module antidote protein HigA
ACIAD_RS10095	COG0714	Associated with various cellular activities
ACIAD_RS10100	COG2879	small protein
ACIAD_RS10105	COG1966	Carbon starvation protein
ACIAD_RS10110	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACIAD_RS10115	COG1509	lysine 2,3-aminomutase activity
ACIAD_RS10130	COG0254	rRNA binding
ACIAD_RS10150	COG1067	ATP-dependent peptidase activity
ACIAD_RS10160	COG3022	response to hydroperoxide
ACIAD_RS10170	COG2195	Cleaves the N-terminal amino acid of tripeptides
ACIAD_RS10180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACIAD_RS10195	COG0693	protein deglycase activity
ACIAD_RS10200	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS10205	COG1301	dicarboxylic acid transport
ACIAD_RS10210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIAD_RS10215	COG3139	Protein of unknown function (DUF1315)
ACIAD_RS10220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACIAD_RS10225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACIAD_RS10245	COG0642	Histidine kinase
ACIAD_RS10265	COG2203	Gaf domain
ACIAD_RS10265	COG2199	diguanylate cyclase activity
ACIAD_RS10270	COG1720	tRNA m6t6A37 methyltransferase activity
ACIAD_RS10290	COG1953	Uracil, thiamine, allantoin
ACIAD_RS10300	COG3384	dioxygenase
ACIAD_RS10305	COG3634	alkyl hydroperoxide reductase activity
ACIAD_RS10325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACIAD_RS10345	COG1131	(ABC) transporter
ACIAD_RS10350	COG0842	Transport permease protein
ACIAD_RS10355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIAD_RS10355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACIAD_RS10365	COG0772	Belongs to the SEDS family
ACIAD_RS10370	COG2951	lytic endotransglycosylase activity
ACIAD_RS10390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACIAD_RS10395	COG0052	Belongs to the universal ribosomal protein uS2 family
ACIAD_RS10400	COG0024	Methionine aminopeptidase
ACIAD_RS10410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD_RS10415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACIAD_RS10420	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS10430	COG3706	GGDEF domain
ACIAD_RS10435	COG0477	Major facilitator Superfamily
ACIAD_RS10445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ACIAD_RS10455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACIAD_RS10465	COG0617	tRNA 3'-terminal CCA addition
ACIAD_RS10480	COG1294	oxidase, subunit
ACIAD_RS10510	COG0552	protein localization to endoplasmic reticulum
ACIAD_RS10515	COG0612	Peptidase, M16
ACIAD_RS10545	COG4109	DRTGG domain
ACIAD_RS10555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIAD_RS10565	COG3100	YcgL domain-containing protein
ACIAD_RS10575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACIAD_RS10630	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACIAD_RS10635	COG4773	Receptor
ACIAD_RS10650	COG0730	response to heat
ACIAD_RS10655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACIAD_RS10660	COG1253	flavin adenine dinucleotide binding
ACIAD_RS10680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACIAD_RS10700	COG0284	orotidine-5'-phosphate decarboxylase activity
ACIAD_RS10710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ACIAD_RS10725	COG0776	regulation of translation
ACIAD_RS10735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACIAD_RS10755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACIAD_RS10765	COG3156	type II secretion system protein K
ACIAD_RS10780	COG2165	general secretion pathway protein
ACIAD_RS10790	COG0084	hydrolase, TatD family'
ACIAD_RS10805	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACIAD_RS10810	COG1663	tetraacyldisaccharide 4'-kinase activity
ACIAD_RS10815	COG1132	(ABC) transporter
ACIAD_RS10820	COG1475	DNA binding
ACIAD_RS10825	COG1192	Involved in chromosome partitioning
ACIAD_RS10830	COG0357	Ribosomal RNA small subunit methyltransferase G
ACIAD_RS10835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACIAD_RS10845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACIAD_RS10850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACIAD_RS10855	COG1923	regulation of RNA biosynthetic process
ACIAD_RS10860	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACIAD_RS10865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACIAD_RS10870	COG0802	atpase or kinase
ACIAD_RS10875	COG0564	pseudouridine synthase activity
ACIAD_RS10890	COG1187	pseudouridine synthase activity
ACIAD_RS10895	COG2707	UPF0756 membrane protein
ACIAD_RS10900	COG0583	DNA-binding transcription factor activity
ACIAD_RS10905	COG2814	Major facilitator Superfamily
ACIAD_RS10910	COG1957	nucleoside hydrolase
ACIAD_RS10920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ACIAD_RS10925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACIAD_RS10935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACIAD_RS10965	COG1937	Protein conserved in bacteria
ACIAD_RS10975	COG2217	Heavy metal translocating P-type atpase
ACIAD_RS10985	COG0729	surface antigen
ACIAD_RS10990	COG0477	Major facilitator Superfamily
ACIAD_RS10995	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ACIAD_RS11010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ACIAD_RS11020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACIAD_RS11030	COG0443	Heat shock 70 kDa protein
ACIAD_RS11035	COG0392	lysyltransferase activity
ACIAD_RS11045	COG2890	protein-(glutamine-N5) methyltransferase activity
ACIAD_RS11050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACIAD_RS11060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS11065	COG3300	MHYT domain
ACIAD_RS11065	COG5001	Diguanylate cyclase
ACIAD_RS11070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACIAD_RS11085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACIAD_RS11090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACIAD_RS11095	COG1845	cytochrome c oxidase, subunit III
ACIAD_RS11100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACIAD_RS11105	COG0109	protoheme IX farnesyltransferase activity
ACIAD_RS11110	COG0360	Binds together with S18 to 16S ribosomal RNA
ACIAD_RS11115	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACIAD_RS11120	COG0359	binds to the 23S rRNA
ACIAD_RS11125	COG0305	Participates in initiation and elongation during chromosome replication
ACIAD_RS11130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACIAD_RS11140	COG1305	Transglutaminase-like
ACIAD_RS11150	COG2308	Evidence 4 Homologs of previously reported genes of
ACIAD_RS11160	COG0445	tRNA wobble uridine modification
ACIAD_RS11170	COG2264	protein methyltransferase activity
ACIAD_RS11180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
ACIAD_RS11185	COG0138	bifunctional purine biosynthesis protein purh
ACIAD_RS11190	COG0151	Belongs to the GarS family
ACIAD_RS11200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACIAD_RS11205	COG2011	ABC-type metal ion transport system permease component
ACIAD_RS11220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACIAD_RS11225	COG3161	chorismate lyase activity
ACIAD_RS11235	COG0174	glutamine synthetase
ACIAD_RS11245	COG0512	Glutamine amidotransferase of anthranilate synthase
ACIAD_RS11250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACIAD_RS11255	COG0134	indole-3-glycerol-phosphate synthase activity
ACIAD_RS11270	COG3608	succinylglutamate desuccinylase aspartoacylase
ACIAD_RS11270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACIAD_RS11275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ACIAD_RS11285	COG0302	gtp cyclohydrolase
ACIAD_RS11290	COG0586	Pfam SNARE associated Golgi protein
ACIAD_RS11300	COG3739	integral membrane protein
ACIAD_RS11305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACIAD_RS11315	COG1741	Belongs to the pirin family
ACIAD_RS11370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ACIAD_RS11375	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
ACIAD_RS11385	COG0535	radical SAM domain protein
ACIAD_RS11395	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS11400	COG2610	gluconate transmembrane transporter activity
ACIAD_RS11405	COG0583	DNA-binding transcription factor activity
ACIAD_RS11420	COG2031	fatty acid transporter
ACIAD_RS11425	COG0183	Belongs to the thiolase family
ACIAD_RS11430	COG4770	biotin carboxylase activity
ACIAD_RS11440	COG4336	lyase activity
ACIAD_RS11445	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ACIAD_RS11450	COG1914	H( )-stimulated, divalent metal cation uptake system
ACIAD_RS11455	COG0583	DNA-binding transcription factor activity
ACIAD_RS11470	COG0069	glutamate synthase activity
ACIAD_RS11475	COG2218	PFAM glutamate synthase alpha subunit domain protein
ACIAD_RS11480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ACIAD_RS11500	COG0583	DNA-binding transcription factor activity
ACIAD_RS11505	COG0004	ammonium transporteR
ACIAD_RS11510	COG0477	Major facilitator Superfamily
ACIAD_RS11525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACIAD_RS11530	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS11540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ACIAD_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS11550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS11555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS11560	COG2267	carboxylic ester hydrolase activity
ACIAD_RS11570	COG1802	Transcriptional regulator
ACIAD_RS11585	COG0446	pyridine nucleotide-disulphide oxidoreductase
ACIAD_RS11585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACIAD_RS11600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIAD_RS11635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACIAD_RS11640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACIAD_RS11660	COG2962	Rard protein
ACIAD_RS11670	COG0556	nucleotide-excision repair
ACIAD_RS11685	COG2199	diguanylate cyclase activity
ACIAD_RS11695	COG0436	Aminotransferase
ACIAD_RS11715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACIAD_RS11720	COG1381	Involved in DNA repair and RecF pathway recombination
ACIAD_RS11730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACIAD_RS11735	COG0571	ribonuclease III activity
ACIAD_RS11750	COG0481	GTPase activity
ACIAD_RS11760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACIAD_RS11770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACIAD_RS11775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACIAD_RS11780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACIAD_RS11785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACIAD_RS11800	COG4208	sulfate ABC transporter
ACIAD_RS11805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACIAD_RS11810	COG0583	DNA-binding transcription factor activity
ACIAD_RS11815	COG4625	pathogenesis
ACIAD_RS11820	COG2171	N-acyltransferase activity
ACIAD_RS11825	COG0602	queuosine metabolic process
ACIAD_RS11830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACIAD_RS11840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACIAD_RS11845	COG2353	YceI-like domain
ACIAD_RS11850	COG1051	belongs to the nudix hydrolase family
ACIAD_RS11850	COG1056	cytidyltransferase-related domain
ACIAD_RS11855	COG1024	Enoyl-CoA hydratase
ACIAD_RS11860	COG0778	Nitroreductase
ACIAD_RS11865	COG3323	Protein of unknown function (DUF1653)
ACIAD_RS11865	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACIAD_RS11875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACIAD_RS11875	COG0047	phosphoribosylformylglycinamidine synthase activity
ACIAD_RS11885	COG0632	four-way junction helicase activity
ACIAD_RS11890	COG2255	four-way junction helicase activity
ACIAD_RS11900	COG0824	Thioesterase
ACIAD_RS11920	COG0823	Involved in the tonB-independent uptake of proteins
ACIAD_RS11935	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACIAD_RS11940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACIAD_RS11975	COG0628	permease
ACIAD_RS11980	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACIAD_RS11985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACIAD_RS11990	COG0596	Alpha beta hydrolase
ACIAD_RS12005	COG0658	competence protein
ACIAD_RS12005	COG2333	competence protein COMEC
ACIAD_RS12010	COG1136	(ABC) transporter
ACIAD_RS12015	COG4591	ABC-type transport system involved in lipoprotein release permease component
ACIAD_RS12025	COG1671	Belongs to the UPF0178 family
ACIAD_RS12035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACIAD_RS12045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD_RS12080	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACIAD_RS12090	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACIAD_RS12105	COG1113	amino acid transport
ACIAD_RS12120	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ACIAD_RS12125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIAD_RS12135	COG4638	Rieske (2fe-2S)
ACIAD_RS12140	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACIAD_RS12145	COG0543	2 iron, 2 sulfur cluster binding
ACIAD_RS12145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD_RS12160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS12185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACIAD_RS12280	COG2828	Protein conserved in bacteria
ACIAD_RS12345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS12355	COG1335	isochorismatase
ACIAD_RS12365	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS12370	COG0583	DNA-binding transcription factor activity
ACIAD_RS12395	COG3008	intermembrane lipid transfer
ACIAD_RS12395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACIAD_RS12400	COG2995	paraquat-inducible protein a
ACIAD_RS12420	COG1309	transcriptional regulator
ACIAD_RS12435	COG1280	lysine exporter protein (LysE YggA)
ACIAD_RS12450	COG2267	carboxylic ester hydrolase activity
ACIAD_RS12495	COG1802	Transcriptional regulator
ACIAD_RS12500	COG0534	Mate efflux family protein
ACIAD_RS12515	COG4774	siderophore transport
ACIAD_RS12520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ACIAD_RS12535	COG0019	diaminopimelate decarboxylase activity
ACIAD_RS12540	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ACIAD_RS12545	COG1021	2,3-dihydroxybenzoate-AMP ligase
ACIAD_RS12550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD_RS12560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD_RS12565	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS12570	COG3433	isochorismatase activity
ACIAD_RS12570	COG1535	isochorismatase
ACIAD_RS12575	COG1169	isochorismate synthase
ACIAD_RS12595	COG3210	domain, Protein
ACIAD_RS12600	COG2831	hemolysin activation secretion protein
ACIAD_RS12615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD_RS12625	COG2072	flavoprotein involved in K transport
ACIAD_RS12680	COG3152	Membrane
ACIAD_RS12700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACIAD_RS12710	COG1414	Transcriptional regulator
ACIAD_RS12715	COG2851	Citrate transporter
ACIAD_RS12725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACIAD_RS12730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACIAD_RS12750	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACIAD_RS12760	COG0037	tRNA processing
ACIAD_RS12765	COG1196	nuclear chromosome segregation
ACIAD_RS12765	COG0741	lytic transglycosylase activity
ACIAD_RS12765	COG0739	heme binding
ACIAD_RS12770	COG0501	Belongs to the peptidase M48B family
ACIAD_RS12780	COG2239	Acts as a magnesium transporter
ACIAD_RS12795	COG0459	protein refolding
ACIAD_RS12800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACIAD_RS12810	COG1597	lipid kinase activity
ACIAD_RS12815	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACIAD_RS12835	COG2264	protein methyltransferase activity
ACIAD_RS12840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACIAD_RS12860	COG1929	Belongs to the glycerate kinase type-1 family
ACIAD_RS12875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ACIAD_RS12880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACIAD_RS12885	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACIAD_RS12905	COG0505	Belongs to the CarA family
ACIAD_RS12910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACIAD_RS12920	COG0589	response to stress
ACIAD_RS12930	COG0589	response to stress
ACIAD_RS12950	COG2321	neutral zinc metallopeptidase
ACIAD_RS12955	COG2354	Protein conserved in bacteria
ACIAD_RS12970	COG0045	succinate-CoA ligase (ADP-forming) activity
ACIAD_RS12975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD_RS12990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACIAD_RS12995	COG1053	succinate dehydrogenase
ACIAD_RS13000	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ACIAD_RS13005	COG2009	succinate dehydrogenase
ACIAD_RS13020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD_RS13020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACIAD_RS13045	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACIAD_RS13050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACIAD_RS13055	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACIAD_RS13070	COG0564	pseudouridine synthase activity
ACIAD_RS13080	COG0358	DNA primase activity
ACIAD_RS13085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACIAD_RS13095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACIAD_RS13100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACIAD_RS13130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACIAD_RS13135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACIAD_RS13140	COG0193	aminoacyl-tRNA hydrolase activity
ACIAD_RS13145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACIAD_RS13150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIAD_RS13160	COG1054	Belongs to the UPF0176 family
ACIAD_RS13170	COG0586	Pfam SNARE associated Golgi protein
ACIAD_RS13185	COG0500	methyltransferase
ACIAD_RS13210	COG0321	lipoyl(octanoyl) transferase activity
ACIAD_RS13225	COG0531	amino acid
ACIAD_RS13235	COG1733	regulation of RNA biosynthetic process
ACIAD_RS13240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ACIAD_RS13245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACIAD_RS13245	COG1648	precorrin-2 dehydrogenase activity
ACIAD_RS13250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACIAD_RS13260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACIAD_RS13265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACIAD_RS13270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACIAD_RS13285	COG0671	phosphoesterase, PA-phosphatase related
ACIAD_RS13290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD_RS13300	COG1538	Outer membrane efflux protein
ACIAD_RS13305	COG0393	Putative heavy-metal-binding
ACIAD_RS13310	COG0393	Putative heavy-metal-binding
ACIAD_RS13315	COG1028	Short-chain dehydrogenase reductase Sdr
ACIAD_RS13325	COG0525	valine-tRNA ligase activity
ACIAD_RS13360	COG0004	ammonium transporteR
ACIAD_RS13370	COG0642	Histidine kinase
ACIAD_RS13375	COG0745	RESPONSE REGULATOR receiver
ACIAD_RS13380	COG2814	Major facilitator Superfamily
ACIAD_RS13390	COG1752	Esterase of the alpha-beta hydrolase superfamily
ACIAD_RS13405	COG0142	geranyltranstransferase activity
ACIAD_RS13410	COG1113	amino acid transport
ACIAD_RS13425	COG0745	RESPONSE REGULATOR receiver
ACIAD_RS13430	COG2205	protein histidine kinase activity
ACIAD_RS13440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACIAD_RS13445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACIAD_RS13465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACIAD_RS13480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACIAD_RS13485	COG2207	Transcriptional regulator
ACIAD_RS13495	COG0183	Belongs to the thiolase family
ACIAD_RS13510	COG4667	esterase of the alpha-beta hydrolase superfamily
ACIAD_RS13535	COG1272	protein, Hemolysin III
ACIAD_RS13540	COG0477	Major facilitator Superfamily
ACIAD_RS13550	COG1408	metallophosphoesterase
ACIAD_RS13555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACIAD_RS13565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACIAD_RS13580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACIAD_RS13585	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACIAD_RS13590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACIAD_RS13595	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACIAD_RS13600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACIAD_RS13605	COG0625	glutathione transferase activity
ACIAD_RS13610	COG2969	positive regulation of protein catabolic process
ACIAD_RS13660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD_RS13665	COG1846	Transcriptional regulator
ACIAD_RS13670	COG1764	response to oxidative stress
ACIAD_RS13710	COG0037	tRNA processing
ACIAD_RS13720	COG0248	Ppx GppA phosphatase
ACIAD_RS13740	COG0776	regulation of translation
ACIAD_RS13745	COG0072	phenylalanine-tRNA ligase activity
ACIAD_RS13750	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACIAD_RS13775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACIAD_RS13790	COG1238	metal cluster binding
ACIAD_RS13795	COG0625	glutathione transferase activity
ACIAD_RS13805	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACIAD_RS13810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACIAD_RS13815	COG0318	PFAM AMP-dependent synthetase and ligase
ACIAD_RS13820	COG3028	Belongs to the UPF0307 family
ACIAD_RS13825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACIAD_RS13830	COG1660	Displays ATPase and GTPase activities
ACIAD_RS13835	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACIAD_RS13840	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACIAD_RS13845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ACIAD_RS13850	COG0617	tRNA 3'-terminal CCA addition
ACIAD_RS13855	COG1596	polysaccharide export
ACIAD_RS13855	COG1555	photosystem II stabilization
ACIAD_RS13860	COG3956	TIGRFAM MazG family protein
ACIAD_RS13870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD_RS13875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACIAD_RS13890	COG2205	protein histidine kinase activity
ACIAD_RS13890	COG5002	protein histidine kinase activity
ACIAD_RS13890	COG0784	Response regulator, receiver
ACIAD_RS13895	COG1024	Enoyl-CoA hydratase
ACIAD_RS13900	COG2084	Dehydrogenase
ACIAD_RS13905	COG3622	Belongs to the hyi family
ACIAD_RS13935	COG0697	spore germination
ACIAD_RS13940	COG0789	Transcriptional regulator
ACIAD_RS13950	COG2814	Major facilitator Superfamily
ACIAD_RS13955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACIAD_RS13965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACIAD_RS13980	COG0084	hydrolase, TatD family'
ACIAD_RS13995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACIAD_RS14005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACIAD_RS14015	COG0028	Belongs to the TPP enzyme family
ACIAD_RS14025	COG0495	leucyl-tRNA aminoacylation
ACIAD_RS14040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD_RS14045	COG0577	efflux transmembrane transporter activity
ACIAD_RS14045	COG1136	(ABC) transporter
ACIAD_RS14050	COG1538	Outer membrane efflux protein
ACIAD_RS14055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIAD_RS14060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACIAD_RS14085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACIAD_RS14090	COG1162	GTPase activity
ACIAD_RS14100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACIAD_RS14105	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACIAD_RS14110	COG3783	Cytochrome b(562)
ACIAD_RS14115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACIAD_RS14120	COG2003	Belongs to the UPF0758 family
ACIAD_RS14125	COG3781	membrane
ACIAD_RS14130	COG0667	Aldo Keto reductase
ACIAD_RS14135	COG0583	DNA-binding transcription factor activity
ACIAD_RS14155	COG2350	Protein conserved in bacteria
ACIAD_RS14165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACIAD_RS14165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACIAD_RS14175	COG1666	GTP binding
ACIAD_RS14185	COG1607	acyl-coa hydrolase
ACIAD_RS14215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACIAD_RS14260	COG1183	phosphatidylcholine synthase activity
ACIAD_RS14265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACIAD_RS14285	COG0039	L-malate dehydrogenase activity
ACIAD_RS14300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACIAD_RS14305	COG1702	phosphate starvation-inducible protein PhoH
ACIAD_RS14310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACIAD_RS14315	COG4773	Receptor
ACIAD_RS14330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACIAD_RS14350	COG1295	ribonuclease BN
ACIAD_RS14355	COG0583	DNA-binding transcription factor activity
ACIAD_RS14360	COG2814	Major facilitator Superfamily
ACIAD_RS14365	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACIAD_RS14390	COG2205	protein histidine kinase activity
ACIAD_RS14415	COG0557	exoribonuclease II activity
ACIAD_RS14420	COG0339	signal peptide processing
ACIAD_RS14425	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
ACIAD_RS14450	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACIAD_RS14455	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS14460	COG2072	flavoprotein involved in K transport
ACIAD_RS14465	COG0203	ribosomal protein L17
ACIAD_RS14470	COG0202	RNA polymerase activity
ACIAD_RS14475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACIAD_RS14485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACIAD_RS14500	COG0200	Binds to the 23S rRNA
ACIAD_RS14505	COG1841	ribosomal large subunit assembly
ACIAD_RS14510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACIAD_RS14515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACIAD_RS14520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACIAD_RS14525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACIAD_RS14530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACIAD_RS14535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACIAD_RS14540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACIAD_RS14545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACIAD_RS14550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACIAD_RS14555	COG0255	Belongs to the universal ribosomal protein uL29 family
ACIAD_RS14560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACIAD_RS14565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACIAD_RS14570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACIAD_RS14575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACIAD_RS14580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACIAD_RS14585	COG0089	rRNA binding
ACIAD_RS14590	COG0088	Forms part of the polypeptide exit tunnel
ACIAD_RS14595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACIAD_RS14600	COG0051	transcription antitermination factor activity, RNA binding
ACIAD_RS14610	COG0626	cystathionine gamma-synthase activity
ACIAD_RS14615	COG0433	COG0433 Predicted ATPase
ACIAD_RS14625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACIAD_RS14625	COG1017	nitric oxide dioxygenase activity
ACIAD_RS14630	COG1959	2 iron, 2 sulfur cluster binding
ACIAD_RS14635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACIAD_RS14645	COG1301	dicarboxylic acid transport
ACIAD_RS14650	COG1946	Acyl-CoA thioesterase
ACIAD_RS14655	COG2937	Belongs to the GPAT DAPAT family
ACIAD_RS14670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACIAD_RS14675	COG1040	competence protein
ACIAD_RS14680	COG0494	nUDIX hydrolase
ACIAD_RS14690	COG0598	Magnesium transport protein CorA
ACIAD_RS14710	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACIAD_RS14715	COG1127	ABC transporter
ACIAD_RS14720	COG0513	Belongs to the DEAD box helicase family
ACIAD_RS14730	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACIAD_RS14735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ACIAD_RS14740	COG0408	coproporphyrinogen oxidase activity
ACIAD_RS14750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACIAD_RS14755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACIAD_RS14765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ACIAD_RS14775	COG0644	oxidoreductase
ACIAD_RS14775	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
ACIAD_RS14785	COG1960	acyl-CoA dehydrogenase activity
ACIAD_RS14795	COG1983	PspC domain protein
ACIAD_RS14800	COG0517	IMP dehydrogenase activity
ACIAD_RS14800	COG0617	tRNA 3'-terminal CCA addition
ACIAD_RS14800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ACIAD_RS14810	COG0752	glycyl-tRNA synthetase alpha subunit
ACIAD_RS14815	COG0751	glycine-tRNA ligase activity
ACIAD_RS14830	COG0583	DNA-binding transcription factor activity
ACIAD_RS14845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACIAD_RS14885	COG1192	Involved in chromosome partitioning
ACIAD_RS14890	COG0628	permease
ACIAD_RS14900	COG1289	transmembrane transporter activity
ACIAD_RS14910	COG2249	NAD(P)H dehydrogenase (quinone) activity
ACIAD_RS14915	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ACIAD_RS14920	COG2131	deaminase
ACIAD_RS14925	COG4221	oxidoreductase activity
ACIAD_RS14935	COG0277	FAD linked oxidase domain protein
ACIAD_RS14940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACIAD_RS14965	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACIAD_RS14970	COG5380	lipid catabolic process
ACIAD_RS14975	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ACIAD_RS14980	COG0335	large ribosomal subunit rRNA binding
ACIAD_RS14985	COG0336	Belongs to the RNA methyltransferase TrmD family
ACIAD_RS14990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACIAD_RS14995	COG0228	four-way junction DNA binding
ACIAD_RS15035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACIAD_RS15040	COG0194	GDP metabolic process
ACIAD_RS15045	COG1758	RNA polymerase activity
ACIAD_RS15050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACIAD_RS15095	COG3307	-O-antigen
ACIAD_RS15100	COG4969	Belongs to the N-Me-Phe pilin family
ACIAD_RS15110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACIAD_RS15120	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIAD_RS15135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACIAD_RS15140	COG1704	LemA family
ACIAD_RS15150	COG0493	'glutamate synthase
ACIAD_RS15155	COG0067	glutamate synthase
ACIAD_RS15155	COG0069	glutamate synthase activity
ACIAD_RS15155	COG0070	glutamate synthase
ACIAD_RS15165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACIAD_RS15170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACIAD_RS15205	COG2226	methyltransferase
ACIAD_RS15210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACIAD_RS15215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ACIAD_RS15220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACIAD_RS15235	COG0275	rRNA processing
ACIAD_RS15250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACIAD_RS15295	COG0488	(ABC) transporter
ACIAD_RS15300	COG0028	Belongs to the TPP enzyme family
ACIAD_RS15305	COG2873	o-acetylhomoserine
ACIAD_RS15310	COG4221	oxidoreductase activity
ACIAD_RS15335	COG0427	acetyl-CoA hydrolase
ACIAD_RS15370	COG0131	Imidazoleglycerol-phosphate dehydratase
ACIAD_RS15375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ACIAD_RS15380	COG3152	Membrane
ACIAD_RS15385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACIAD_RS15390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACIAD_RS15395	COG1132	(ABC) transporter
ACIAD_RS15410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ACIAD_RS15415	COG0107	imidazoleglycerol-phosphate synthase activity
ACIAD_RS15445	COG3158	transport of potassium into the cell
ACIAD_RS15490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACIAD_RS15560	COG0475	glutathione-regulated potassium exporter activity
ACIAD_RS15560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACIAD_RS15575	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACIAD_RS15585	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS15590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACIAD_RS15605	COG0629	single-stranded DNA binding
ACIAD_RS15610	COG2814	Major facilitator Superfamily
ACIAD_RS15620	COG0351	phosphomethylpyrimidine kinase
ACIAD_RS15620	COG0352	thiamine-phosphate diphosphorylase activity
ACIAD_RS15620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ACIAD_RS15625	COG3136	membrane protein required for alginate biosynthesis
ACIAD_RS15655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACIAD_RS15670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACIAD_RS15675	COG3162	membrane
ACIAD_RS15695	COG0431	NADPH-dependent FMN reductase
ACIAD_RS15700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACIAD_RS15710	COG1335	isochorismatase
ACIAD_RS15720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACIAD_RS15725	COG3152	Membrane
ACIAD_RS15730	COG0668	transmembrane transport
ACIAD_RS15740	COG1519	Transferase
ACIAD_RS15745	COG2072	flavoprotein involved in K transport
ACIAD_RS15760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
ACIAD_RS15780	COG1126	abc transporter atp-binding protein
ACIAD_RS15805	COG1902	pentaerythritol trinitrate reductase activity
ACIAD_RS15815	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACIAD_RS15825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACIAD_RS15830	COG0259	pyridoxamine-phosphate oxidase activity
ACIAD_RS15835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACIAD_RS15850	COG2119	membrane
ACIAD_RS15855	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACIAD_RS15865	COG4942	peptidase
ACIAD_RS15875	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACIAD_RS15880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ACIAD_RS15890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACIAD_RS15895	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACIAD_RS15900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIAD_RS15905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACIAD_RS15910	COG0189	ligase activity
ACIAD_RS15925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACIAD_RS15940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACIAD_RS15945	COG0708	Exodeoxyribonuclease III
ACIAD_RS15950	COG1393	Belongs to the ArsC family
ACIAD_RS15965	COG3706	GGDEF domain
ACIAD_RS16010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACIAD_RS16015	COG4266	Belongs to the allantoicase family
ACIAD_RS16035	COG3150	esterase
ACIAD_RS16045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ACIAD_RS16050	COG2918	glutathione biosynthetic process
ACIAD_RS16065	COG2733	membrane
ACIAD_RS16070	COG0436	Aminotransferase
ACIAD_RS16075	COG0534	Mate efflux family protein
ACIAD_RS16105	COG0688	phosphatidylethanolamine metabolic process
ACIAD_RS16115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ACIAD_RS16120	COG1490	D-aminoacyl-tRNA deacylase activity
ACIAD_RS16140	COG0560	Phosphoserine phosphatase
ACIAD_RS16140	COG3830	Belongs to the UPF0237 family
ACIAD_RS16155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACIAD_RS16160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACIAD_RS16165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ACIAD_RS16170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACIAD_RS16175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACIAD_RS16180	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ACIAD_RS16200	COG2388	GCN5-related N-acetyl-transferase
ACIAD_RS16205	COG1683	Conserved Protein
ACIAD_RS16210	COG0385	Bile acid
ACIAD_RS16215	COG1335	isochorismatase
ACIAD_RS16220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACIAD_RS16230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACIAD_RS16240	COG0765	amino acid transport
ACIAD_RS16245	COG0765	amino acid transport
ACIAD_RS16250	COG1126	abc transporter atp-binding protein
ACIAD_RS16255	COG2116	formate transmembrane transporter activity
ACIAD_RS16265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACIAD_RS16275	COG2133	pyrroloquinoline quinone binding
ACIAD_RS16290	COG2983	Belongs to the UPF0260 family
ACIAD_RS16300	COG0412	Dienelactone hydrolase
ACIAD_RS16310	COG1194	a g-specific adenine glycosylase
ACIAD_RS16330	COG2818	Glycosylase
ACIAD_RS16335	COG1064	alcohol dehydrogenase
ACIAD_RS16340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACIAD_RS16350	COG0583	DNA-binding transcription factor activity
ACIAD_RS16355	COG0656	L-ascorbic acid biosynthetic process
ACIAD_RS16360	COG2814	Major facilitator Superfamily
ACIAD_RS16370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ACIAD_RS16375	COG0484	heat shock protein binding
ACIAD_RS16400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACIAD_RS16405	COG2233	PERMEase
ACIAD_RS16410	COG0583	DNA-binding transcription factor activity
ACIAD_RS16420	COG1252	NADH dehydrogenase
ACIAD_RS16430	COG0129	dihydroxy-acid dehydratase activity
ACIAD_RS16435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACIAD_RS16440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACIAD_RS16445	COG0428	transporter
ACIAD_RS16450	COG0733	neurotransmitter:sodium symporter activity
ACIAD_RS16455	COG1012	belongs to the aldehyde dehydrogenase family
ACIAD_RS16470	COG0693	protein deglycase activity
ACIAD_RS16500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACIAD_RS16505	COG0657	acetylesterase activity
ACIAD_RS16520	COG0583	DNA-binding transcription factor activity
ACIAD_RS16525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACIAD_RS16530	COG0443	Heat shock 70 kDa protein
ACIAD_RS16540	COG2951	lytic endotransglycosylase activity
ACIAD_RS16565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACIAD_RS16570	COG0671	phosphoesterase, PA-phosphatase related
ACIAD_RS16575	COG0861	Integral membrane protein TerC family
ACIAD_RS16585	COG0402	S-adenosylhomocysteine deaminase activity
ACIAD_RS16635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACIAD_RS16640	COG0706	membrane insertase activity
ACIAD_RS16645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ACIAD_RS16650	COG0594	ribonuclease P activity
ACIAD_RS16800	COG4890	Cyd operon protein YbgT
ACIAD_RS16895	COG5487	UPF0391 membrane protein