locus-tag	class	description
I9192_RS00010	COG0592	DNA-directed DNA polymerase activity
I9192_RS00020	COG0187	DNA topoisomerase II activity
I9192_RS00030	COG0488	(ABC) transporter
I9192_RS00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I9192_RS00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I9192_RS00050	COG0596	Alpha beta hydrolase
I9192_RS00070	COG0657	acetylesterase activity
I9192_RS00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I9192_RS00215	COG1309	transcriptional regulator
I9192_RS00220	COG1116	anion transmembrane transporter activity
I9192_RS00225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_RS00230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_RS00235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_RS00240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_RS00245	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I9192_RS00245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I9192_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS00275	COG0546	phosphoglycolate phosphatase activity
I9192_RS00280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I9192_RS00295	COG1309	transcriptional regulator
I9192_RS00315	COG2207	Transcriptional regulator
I9192_RS00325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I9192_RS00355	COG3023	N-Acetylmuramoyl-L-alanine amidase
I9192_RS00385	COG1596	polysaccharide export
I9192_RS00410	COG2244	polysaccharide biosynthetic process
I9192_RS00440	COG1216	Glycosyl transferase, family 2
I9192_RS00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I9192_RS00450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I9192_RS00465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9192_RS00470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9192_RS00505	COG1454	alcohol dehydrogenase
I9192_RS00525	COG0235	Class ii aldolase
I9192_RS00545	COG0271	Belongs to the BolA IbaG family
I9192_RS00555	COG1192	Involved in chromosome partitioning
I9192_RS00565	COG0586	Pfam SNARE associated Golgi protein
I9192_RS00570	COG2259	Doxx family
I9192_RS00580	COG0519	Catalyzes the synthesis of GMP from XMP
I9192_RS00580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9192_RS00610	COG1902	pentaerythritol trinitrate reductase activity
I9192_RS00615	COG1519	Transferase
I9192_RS00620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9192_RS00625	COG0668	transmembrane transport
I9192_RS00635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_RS00655	COG0431	NADPH-dependent FMN reductase
I9192_RS00665	COG2814	Major facilitator Superfamily
I9192_RS00690	COG4452	Inner membrane protein CreD
I9192_RS00695	COG2205	protein histidine kinase activity
I9192_RS00700	COG0745	RESPONSE REGULATOR receiver
I9192_RS00730	COG0281	malic enzyme
I9192_RS00775	COG2837	iron assimilation
I9192_RS00790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I9192_RS00795	COG1121	(ABC) transporter
I9192_RS00815	COG0356	it plays a direct role in the translocation of protons across the membrane
I9192_RS00835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I9192_RS00845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I9192_RS00880	COG3385	transposase activity
I9192_RS00895	COG0386	Belongs to the glutathione peroxidase family
I9192_RS00915	COG1309	transcriptional regulator
I9192_RS00920	COG0697	spore germination
I9192_RS00925	COG0009	L-threonylcarbamoyladenylate synthase
I9192_RS00930	COG0758	DNA mediated transformation
I9192_RS00935	COG1652	LysM domain
I9192_RS00950	COG4771	TonB-dependent receptor
I9192_RS00970	COG1309	transcriptional regulator
I9192_RS01010	COG2133	pyrroloquinoline quinone binding
I9192_RS01030	COG0784	Response regulator, receiver
I9192_RS01030	COG2205	protein histidine kinase activity
I9192_RS01035	COG3162	membrane
I9192_RS01040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_RS01050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_RS01095	COG1253	flavin adenine dinucleotide binding
I9192_RS01105	COG2860	membrane
I9192_RS01115	COG0477	Major facilitator Superfamily
I9192_RS01130	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_RS01145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I9192_RS01185	COG0673	inositol 2-dehydrogenase activity
I9192_RS01200	COG1929	Belongs to the glycerate kinase type-1 family
I9192_RS01205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9192_RS01210	COG0738	Major facilitator superfamily
I9192_RS01230	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS01235	COG1024	Enoyl-CoA hydratase
I9192_RS01260	COG0606	chelatase, subunit chli
I9192_RS01270	COG0347	Belongs to the P(II) protein family
I9192_RS01275	COG0004	ammonium transporteR
I9192_RS01285	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9192_RS01285	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9192_RS01300	COG0586	Pfam SNARE associated Golgi protein
I9192_RS01310	COG0772	Belongs to the SEDS family
I9192_RS01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9192_RS01320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I9192_RS01325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9192_RS01350	COG0704	Plays a role in the regulation of phosphate uptake
I9192_RS01355	COG2873	o-acetylhomoserine
I9192_RS01365	COG0488	(ABC) transporter
I9192_RS01380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I9192_RS01425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I9192_RS01470	COG0427	acetyl-CoA hydrolase
I9192_RS01495	COG0789	Transcriptional regulator
I9192_RS01500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9192_RS01500	COG3320	Male sterility
I9192_RS01510	COG0583	DNA-binding transcription factor activity
I9192_RS01515	COG4221	oxidoreductase activity
I9192_RS01595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9192_RS01635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I9192_RS01640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I9192_RS01645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I9192_RS01650	COG2226	methyltransferase
I9192_RS01700	COG0070	glutamate synthase
I9192_RS01700	COG0067	glutamate synthase
I9192_RS01700	COG0069	glutamate synthase activity
I9192_RS01705	COG0493	'glutamate synthase
I9192_RS01715	COG0307	riboflavin synthase, alpha
I9192_RS01720	COG1320	monovalent cation:proton antiporter activity
I9192_RS01725	COG2212	antiporter activity
I9192_RS01730	COG1863	multisubunit Na H antiporter MnhE subunit
I9192_RS01735	COG0651	ATP synthesis coupled electron transport
I9192_RS01740	COG1006	Multisubunit Na H antiporter MnhC subunit
I9192_RS01745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9192_RS01745	COG2111	Na H antiporter
I9192_RS01770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I9192_RS01790	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS01830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9192_RS01840	COG2226	methyltransferase
I9192_RS01860	COG3385	transposase activity
I9192_RS01870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I9192_RS01875	COG1074	ATP-dependent DNA helicase activity
I9192_RS01880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_RS01885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I9192_RS01900	COG0598	Magnesium transport protein CorA
I9192_RS01905	COG2841	Protein conserved in bacteria
I9192_RS01910	COG0789	Transcriptional regulator
I9192_RS01925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I9192_RS01950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I9192_RS01975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_RS01980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I9192_RS01985	COG4535	Mg2 and Co2 transporter CorC
I9192_RS01990	COG0425	Belongs to the sulfur carrier protein TusA family
I9192_RS02010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I9192_RS02010	COG0644	oxidoreductase
I9192_RS02020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I9192_RS02035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9192_RS02075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I9192_RS02105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I9192_RS02110	COG0254	rRNA binding
I9192_RS02115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9192_RS02125	COG0534	Mate efflux family protein
I9192_RS02135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9192_RS02145	COG1960	acyl-CoA dehydrogenase activity
I9192_RS02165	COG0408	coproporphyrinogen oxidase activity
I9192_RS02170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9192_RS02175	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9192_RS02195	COG0513	Belongs to the DEAD box helicase family
I9192_RS02200	COG1127	ABC transporter
I9192_RS02205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I9192_RS02210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9192_RS02225	COG0598	Magnesium transport protein CorA
I9192_RS02235	COG0494	nUDIX hydrolase
I9192_RS02240	COG1040	competence protein
I9192_RS02245	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I9192_RS02255	COG2937	Belongs to the GPAT DAPAT family
I9192_RS02260	COG1946	Acyl-CoA thioesterase
I9192_RS02265	COG1301	dicarboxylic acid transport
I9192_RS02280	COG1959	2 iron, 2 sulfur cluster binding
I9192_RS02290	COG1017	nitric oxide dioxygenase activity
I9192_RS02290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9192_RS02295	COG0433	COG0433 Predicted ATPase
I9192_RS02300	COG0626	cystathionine gamma-synthase activity
I9192_RS02310	COG0051	transcription antitermination factor activity, RNA binding
I9192_RS02315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I9192_RS02320	COG0088	Forms part of the polypeptide exit tunnel
I9192_RS02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I9192_RS02365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I9192_RS02385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I9192_RS02400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I9192_RS02425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I9192_RS02435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I9192_RS02440	COG0202	RNA polymerase activity
I9192_RS02445	COG0203	ribosomal protein L17
I9192_RS02450	COG2072	flavoprotein involved in K transport
I9192_RS02455	COG1960	acyl-CoA dehydrogenase activity
I9192_RS02460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I9192_RS02500	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I9192_RS02505	COG0339	signal peptide processing
I9192_RS02520	COG0557	exoribonuclease II activity
I9192_RS02550	COG0765	amino acid transport
I9192_RS02555	COG0765	amino acid transport
I9192_RS02560	COG1126	abc transporter atp-binding protein
I9192_RS02565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_RS02570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_RS02580	COG2814	Major facilitator Superfamily
I9192_RS02605	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9192_RS02635	COG0697	spore germination
I9192_RS02640	COG1295	ribonuclease BN
I9192_RS02655	COG1946	Acyl-CoA thioesterase
I9192_RS02690	COG3781	membrane
I9192_RS02695	COG2003	Belongs to the UPF0758 family
I9192_RS02700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I9192_RS02705	COG3783	Cytochrome b(562)
I9192_RS02740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9192_RS02750	COG1162	GTPase activity
I9192_RS02755	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I9192_RS02780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_RS02785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_RS02790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_RS02805	COG1538	Outer membrane efflux protein
I9192_RS02810	COG1136	(ABC) transporter
I9192_RS02810	COG0577	efflux transmembrane transporter activity
I9192_RS02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS02845	COG1309	transcriptional regulator
I9192_RS02850	COG0028	Belongs to the TPP enzyme family
I9192_RS02855	COG0440	acetolactate synthase activity
I9192_RS02860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I9192_RS02900	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I9192_RS02905	COG1426	Protein conserved in bacteria
I9192_RS02940	COG0004	ammonium transporteR
I9192_RS02950	COG3622	Belongs to the hyi family
I9192_RS02955	COG2084	Dehydrogenase
I9192_RS02960	COG1024	Enoyl-CoA hydratase
I9192_RS02965	COG2205	protein histidine kinase activity
I9192_RS02965	COG5002	protein histidine kinase activity
I9192_RS02965	COG0784	Response regulator, receiver
I9192_RS02985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_RS02995	COG3956	TIGRFAM MazG family protein
I9192_RS03000	COG1555	photosystem II stabilization
I9192_RS03010	COG0617	tRNA 3'-terminal CCA addition
I9192_RS03015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I9192_RS03025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I9192_RS03030	COG1660	Displays ATPase and GTPase activities
I9192_RS03035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I9192_RS03040	COG3028	Belongs to the UPF0307 family
I9192_RS03050	COG2205	protein histidine kinase activity
I9192_RS03055	COG0745	RESPONSE REGULATOR receiver
I9192_RS03060	COG2315	Protein conserved in bacteria
I9192_RS03070	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I9192_RS03090	COG2096	Adenosyltransferase
I9192_RS03095	COG4206	TonB-dependent receptor
I9192_RS03125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_RS03135	COG3384	dioxygenase
I9192_RS03170	COG1764	response to oxidative stress
I9192_RS03175	COG1846	Transcriptional regulator
I9192_RS03180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_RS03195	COG2853	Lipoprotein
I9192_RS03235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_RS03235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9192_RS03270	COG0489	protein tyrosine kinase activity
I9192_RS03275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I9192_RS03335	COG0442	prolyl-tRNA aminoacylation
I9192_RS03360	COG0840	transmembrane signaling receptor activity
I9192_RS03365	COG0643	Histidine kinase
I9192_RS03365	COG0784	Response regulator, receiver
I9192_RS03365	COG2198	Histidine kinase
I9192_RS03380	COG3539	Fimbrial protein
I9192_RS03390	COG3121	Chaperone
I9192_RS03400	COG3539	Fimbrial protein
I9192_RS03415	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I9192_RS03430	COG0084	hydrolase, TatD family'
I9192_RS03440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I9192_RS03465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9192_RS03470	COG0583	DNA-binding transcription factor activity
I9192_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03480	COG2271	Major facilitator Superfamily
I9192_RS03485	COG3959	Transketolase, thiamine diphosphate binding domain
I9192_RS03490	COG3958	Transketolase
I9192_RS03500	COG2186	Transcriptional regulator
I9192_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03515	COG4948	Mandelate Racemase Muconate Lactonizing
I9192_RS03525	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03535	COG0738	Major facilitator superfamily
I9192_RS03545	COG2188	Transcriptional regulator
I9192_RS03560	COG0523	cobalamin synthesis protein
I9192_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03580	COG2814	Major facilitator Superfamily
I9192_RS03590	COG0154	amidase activity
I9192_RS03595	COG1609	Transcriptional regulator
I9192_RS03600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_RS03610	COG0154	amidase activity
I9192_RS03635	COG2814	Major facilitator Superfamily
I9192_RS03690	COG1862	Preprotein translocase
I9192_RS03720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I9192_RS03730	COG0582	viral genome integration into host DNA
I9192_RS03740	COG4115	mRNA cleavage
I9192_RS03825	COG0583	DNA-binding transcription factor activity
I9192_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS03845	COG0583	DNA-binding transcription factor activity
I9192_RS03850	COG0247	lactate metabolic process
I9192_RS03850	COG0277	FAD linked oxidase domain protein
I9192_RS03855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_RS03860	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS03865	COG5383	Protein conserved in bacteria
I9192_RS03875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_RS03880	COG5002	protein histidine kinase activity
I9192_RS03885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I9192_RS03910	COG0438	transferase activity, transferring glycosyl groups
I9192_RS03935	COG3306	glycosyltransferase involved in LPS biosynthesis
I9192_RS04015	COG1960	acyl-CoA dehydrogenase activity
I9192_RS04020	COG1960	acyl-CoA dehydrogenase activity
I9192_RS04030	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_RS04075	COG0625	glutathione transferase activity
I9192_RS04090	COG1238	metal cluster binding
I9192_RS04110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I9192_RS04155	COG0072	phenylalanine-tRNA ligase activity
I9192_RS04160	COG0776	regulation of translation
I9192_RS04180	COG0248	Ppx GppA phosphatase
I9192_RS04190	COG0037	tRNA processing
I9192_RS04235	COG5290	Psort location Cytoplasmic, score
I9192_RS04240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I9192_RS04255	COG0745	RESPONSE REGULATOR receiver
I9192_RS04260	COG2205	protein histidine kinase activity
I9192_RS04270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_RS04290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I9192_RS04300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I9192_RS04305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_RS04315	COG0713	ATP synthesis coupled electron transport
I9192_RS04320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9192_RS04325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9192_RS04335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I9192_RS04350	COG0583	DNA-binding transcription factor activity
I9192_RS04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_RS04370	COG2050	protein possibly involved in aromatic compounds catabolism
I9192_RS04375	COG1566	PFAM secretion protein HlyD family protein
I9192_RS04380	COG2814	Major facilitator Superfamily
I9192_RS04385	COG1278	Cold shock
I9192_RS04395	COG3177	Filamentation induced by cAMP protein fic
I9192_RS04410	COG0306	phosphate transporter
I9192_RS04485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9192_RS04500	COG2851	Citrate transporter
I9192_RS04505	COG1253	flavin adenine dinucleotide binding
I9192_RS04525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I9192_RS04530	COG2894	cell division
I9192_RS04535	COG0850	regulation of cytokinetic process
I9192_RS04545	COG0204	Acyl-transferase
I9192_RS04550	COG2885	chlorophyll binding
I9192_RS04560	COG0756	dUTP diphosphatase activity
I9192_RS04565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9192_RS04580	COG0121	glutamine amidotransferase
I9192_RS04585	COG2703	oxygen carrier activity
I9192_RS04595	COG2914	Belongs to the UPF0125 (RnfH) family
I9192_RS04600	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9192_RS04605	COG0735	belongs to the Fur family
I9192_RS04625	COG1968	undecaprenyl-diphosphatase activity
I9192_RS04650	COG0420	3'-5' exonuclease activity
I9192_RS04680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9192_RS04690	COG0786	glutamate:sodium symporter activity
I9192_RS04695	COG2059	Chromate
I9192_RS04700	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9192_RS04705	COG1607	acyl-coa hydrolase
I9192_RS04725	COG0523	cobalamin synthesis protein
I9192_RS04730	COG4681	YaeQ
I9192_RS04750	COG0726	polysaccharide deacetylase
I9192_RS04750	COG1649	PFAM Uncharacterised BCR, COG1649
I9192_RS04755	COG1215	transferase activity, transferring glycosyl groups
I9192_RS04790	COG1309	transcriptional regulator
I9192_RS04800	COG1024	Enoyl-CoA hydratase
I9192_RS04910	COG0305	Participates in initiation and elongation during chromosome replication
I9192_RS04945	COG0582	viral genome integration into host DNA
I9192_RS04955	COG1113	amino acid transport
I9192_RS04960	COG2828	Protein conserved in bacteria
I9192_RS04970	COG0142	geranyltranstransferase activity
I9192_RS04975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_RS04990	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9192_RS05005	COG2194	sulfuric ester hydrolase activity
I9192_RS05015	COG0642	Histidine kinase
I9192_RS05030	COG0004	ammonium transporteR
I9192_RS05055	COG2852	Protein conserved in bacteria
I9192_RS05060	COG0525	valine-tRNA ligase activity
I9192_RS05070	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS05090	COG0393	Putative heavy-metal-binding
I9192_RS05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS05110	COG0671	phosphoesterase, PA-phosphatase related
I9192_RS05125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I9192_RS05135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I9192_RS05145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I9192_RS05150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I9192_RS05150	COG1648	precorrin-2 dehydrogenase activity
I9192_RS05155	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I9192_RS05185	COG0531	amino acid
I9192_RS05200	COG0321	lipoyl(octanoyl) transferase activity
I9192_RS05205	COG2921	Belongs to the UPF0250 family
I9192_RS05230	COG1280	lysine exporter protein (LysE YggA)
I9192_RS05235	COG0586	Pfam SNARE associated Golgi protein
I9192_RS05250	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9192_RS05270	COG0193	aminoacyl-tRNA hydrolase activity
I9192_RS05275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I9192_RS05280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9192_RS05310	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I9192_RS05325	COG0358	DNA primase activity
I9192_RS05335	COG0564	pseudouridine synthase activity
I9192_RS05360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I9192_RS05365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I9192_RS05370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9192_RS05430	COG0477	Major facilitator Superfamily
I9192_RS05455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I9192_RS05460	COG1597	lipid kinase activity
I9192_RS05465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9192_RS05475	COG0459	protein refolding
I9192_RS05485	COG0584	glycerophosphoryl diester phosphodiesterase
I9192_RS05490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_RS05495	COG2239	Acts as a magnesium transporter
I9192_RS05525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_RS05530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9192_RS05535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9192_RS05555	COG1113	amino acid transport
I9192_RS05565	COG0019	diaminopimelate decarboxylase activity
I9192_RS05570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I9192_RS05590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I9192_RS05625	COG3328	transposase activity
I9192_RS05635	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I9192_RS05650	COG0596	Alpha beta hydrolase
I9192_RS05655	COG0833	amino acid
I9192_RS05665	COG0833	amino acid
I9192_RS05675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9192_RS05680	COG0418	dihydroorotase activity
I9192_RS05700	COG0501	Belongs to the peptidase M48B family
I9192_RS05705	COG0741	lytic transglycosylase activity
I9192_RS05710	COG0037	tRNA processing
I9192_RS05720	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I9192_RS05725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9192_RS05760	COG3152	Membrane
I9192_RS05800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9192_RS05820	COG0582	viral genome integration into host DNA
I9192_RS05825	COG0668	transmembrane transport
I9192_RS05830	COG0625	glutathione transferase activity
I9192_RS05835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_RS05845	COG0583	DNA-binding transcription factor activity
I9192_RS05850	COG2610	gluconate transmembrane transporter activity
I9192_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS05875	COG0583	DNA-binding transcription factor activity
I9192_RS05890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9192_RS05940	COG3328	transposase activity
I9192_RS05980	COG1414	Transcriptional regulator
I9192_RS05985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9192_RS05990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_RS05995	COG0183	Belongs to the thiolase family
I9192_RS06000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I9192_RS06005	COG0596	Alpha beta hydrolase
I9192_RS06010	COG2271	Major facilitator Superfamily
I9192_RS06015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_RS06020	COG3485	protocatechuate 3,4-dioxygenase
I9192_RS06025	COG3485	protocatechuate 3,4-dioxygenase
I9192_RS06030	COG0710	3-dehydroquinate dehydratase activity
I9192_RS06035	COG3420	alginic acid biosynthetic process
I9192_RS06040	COG3659	wide pore channel activity
I9192_RS06045	COG4993	Dehydrogenase
I9192_RS06055	COG3121	Chaperone
I9192_RS06060	COG3188	usher protein
I9192_RS06070	COG0583	DNA-binding transcription factor activity
I9192_RS06080	COG0583	DNA-binding transcription factor activity
I9192_RS06095	COG0789	Transcriptional regulator
I9192_RS06115	COG2217	Heavy metal translocating P-type atpase
I9192_RS06120	COG2205	protein histidine kinase activity
I9192_RS06135	COG1923	regulation of RNA biosynthetic process
I9192_RS06145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I9192_RS06150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I9192_RS06160	COG2205	protein histidine kinase activity
I9192_RS06165	COG0745	RESPONSE REGULATOR receiver
I9192_RS06180	COG2832	Protein of unknown function (DUF454)
I9192_RS06190	COG1595	DNA-templated transcription, initiation
I9192_RS06235	COG1629	transport
I9192_RS06275	COG0006	proline dipeptidase activity
I9192_RS06285	COG4771	TonB-dependent receptor
I9192_RS06290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_RS06295	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_RS06345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9192_RS06350	COG0741	lytic transglycosylase activity
I9192_RS06350	COG1388	LysM domain
I9192_RS06355	COG4166	transmembrane transport
I9192_RS06360	COG4174	ABC transporter (Permease)
I9192_RS06365	COG4239	(ABC) transporter, permease
I9192_RS06370	COG4172	Belongs to the ABC transporter superfamily
I9192_RS06390	COG0024	Methionine aminopeptidase
I9192_RS06395	COG0052	Belongs to the universal ribosomal protein uS2 family
I9192_RS06400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I9192_RS06450	COG2951	lytic endotransglycosylase activity
I9192_RS06455	COG0772	Belongs to the SEDS family
I9192_RS06470	COG0842	Transport permease protein
I9192_RS06475	COG1131	(ABC) transporter
I9192_RS06485	COG0582	viral genome integration into host DNA
I9192_RS06580	COG0305	Participates in initiation and elongation during chromosome replication
I9192_RS06660	COG5410	chromosome segregation
I9192_RS06785	COG3772	lysozyme
I9192_RS06800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9192_RS06865	COG0305	Participates in initiation and elongation during chromosome replication
I9192_RS06910	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS06930	COG0673	inositol 2-dehydrogenase activity
I9192_RS06935	COG1324	tolerance protein
I9192_RS06960	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS06970	COG3620	sequence-specific DNA binding
I9192_RS07030	COG5410	chromosome segregation
I9192_RS07035	COG3567	Phage-associated protein, HI1409 family
I9192_RS07055	COG3566	protein conserved in bacteria
I9192_RS07170	COG0582	viral genome integration into host DNA
I9192_RS07220	COG1476	TRANSCRIPTIONal
I9192_RS07275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9192_RS07290	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I9192_RS07300	COG2233	PERMEase
I9192_RS07310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS07315	COG1823	symporter activity
I9192_RS07335	COG0612	Peptidase, M16
I9192_RS07360	COG1720	tRNA m6t6A37 methyltransferase activity
I9192_RS07365	COG3025	triphosphatase activity
I9192_RS07380	COG0352	thiamine-phosphate diphosphorylase activity
I9192_RS07425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I9192_RS07430	COG3111	PFAM Bacterial OB fold (BOF) protein
I9192_RS07440	COG0642	Histidine kinase
I9192_RS07450	COG0494	nUDIX hydrolase
I9192_RS07460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9192_RS07465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I9192_RS07470	COG3139	Protein of unknown function (DUF1315)
I9192_RS07480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9192_RS07485	COG1301	dicarboxylic acid transport
I9192_RS07490	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I9192_RS07500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I9192_RS07550	COG5377	YqaJ viral recombinase family
I9192_RS07590	COG4197	protein conserved in bacteria, prophage-related
I9192_RS07825	COG2318	DinB family
I9192_RS07830	COG2070	2-Nitropropane dioxygenase
I9192_RS07860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I9192_RS07885	COG1643	Atp-dependent helicase
I9192_RS07925	COG2831	hemolysin activation secretion protein
I9192_RS07930	COG2188	Transcriptional regulator
I9192_RS07950	COG1113	amino acid transport
I9192_RS07960	COG0010	Belongs to the arginase family
I9192_RS07965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_RS07985	COG2072	flavoprotein involved in K transport
I9192_RS08010	COG1136	(ABC) transporter
I9192_RS08015	COG2333	competence protein COMEC
I9192_RS08015	COG0658	competence protein
I9192_RS08035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I9192_RS08045	COG0628	permease
I9192_RS08085	COG3634	alkyl hydroperoxide reductase activity
I9192_RS08090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I9192_RS08095	COG0583	DNA-binding transcription factor activity
I9192_RS08100	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9192_RS08105	COG0826	peptidase U32
I9192_RS08115	COG0640	Transcriptional regulator
I9192_RS08120	COG0798	PFAM Bile acid sodium symporter
I9192_RS08125	COG0789	Transcriptional regulator
I9192_RS08170	COG1022	Amp-dependent synthetase and ligase
I9192_RS08185	COG1309	transcriptional regulator
I9192_RS08215	COG4772	TonB-dependent receptor
I9192_RS08225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9192_RS08230	COG0076	glutamate decarboxylase activity
I9192_RS08240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I9192_RS08275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I9192_RS08290	COG0642	Histidine kinase
I9192_RS08295	COG0745	RESPONSE REGULATOR receiver
I9192_RS08380	COG0583	DNA-binding transcription factor activity
I9192_RS08395	COG2995	paraquat-inducible protein a
I9192_RS08400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9192_RS08400	COG3008	intermembrane lipid transfer
I9192_RS08430	COG0693	protein deglycase activity
I9192_RS08450	COG5487	UPF0391 membrane protein
I9192_RS08460	COG1309	transcriptional regulator
I9192_RS08465	COG2814	Major facilitator Superfamily
I9192_RS08480	COG0477	Major facilitator Superfamily
I9192_RS08485	COG1309	transcriptional regulator
I9192_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS08490	COG3321	synthase
I9192_RS08490	COG0604	alcohol dehydrogenase
I9192_RS08510	COG1785	Belongs to the alkaline phosphatase family
I9192_RS08525	COG1454	alcohol dehydrogenase
I9192_RS08530	COG2610	gluconate transmembrane transporter activity
I9192_RS08540	COG2814	Major facilitator Superfamily
I9192_RS08545	COG2207	Transcriptional regulator
I9192_RS08545	COG3708	Transcriptional regulator
I9192_RS08565	COG0154	amidase activity
I9192_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS08600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS08610	COG0583	DNA-binding transcription factor activity
I9192_RS08625	COG0642	Histidine kinase
I9192_RS08680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_RS08685	COG2271	Major facilitator Superfamily
I9192_RS08695	COG2267	carboxylic ester hydrolase activity
I9192_RS08700	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS08715	COG0028	Belongs to the TPP enzyme family
I9192_RS08750	COG0477	Major facilitator Superfamily
I9192_RS08760	COG2223	nitrite transmembrane transporter activity
I9192_RS08770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS08790	COG0436	Aminotransferase
I9192_RS08805	COG5001	Diguanylate cyclase
I9192_RS08805	COG3300	MHYT domain
I9192_RS08815	COG0556	nucleotide-excision repair
I9192_RS08825	COG2962	Rard protein
I9192_RS08860	COG0702	epimerase
I9192_RS08865	COG1733	regulation of RNA biosynthetic process
I9192_RS08880	COG2915	High frequency lysogenization protein hflD homolog
I9192_RS08915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9192_RS08920	COG1686	Belongs to the peptidase S11 family
I9192_RS08935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I9192_RS08940	COG4942	peptidase
I9192_RS08950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9192_RS08955	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9192_RS08960	COG1067	ATP-dependent peptidase activity
I9192_RS08995	COG1509	lysine 2,3-aminomutase activity
I9192_RS09000	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I9192_RS09005	COG1966	Carbon starvation protein
I9192_RS09010	COG2879	small protein
I9192_RS09020	COG0714	Associated with various cellular activities
I9192_RS09040	COG0582	viral genome integration into host DNA
I9192_RS09070	COG4771	TonB-dependent receptor
I9192_RS09105	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_RS09120	COG2252	PERMEase
I9192_RS09125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I9192_RS09135	COG3038	cytochrome b561
I9192_RS09145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I9192_RS09155	COG0527	aspartate kinase activity
I9192_RS09175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I9192_RS09195	COG1522	sequence-specific DNA binding
I9192_RS09200	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I9192_RS09205	COG1522	sequence-specific DNA binding
I9192_RS09210	COG1335	isochorismatase
I9192_RS09225	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I9192_RS09245	COG0667	Aldo Keto reductase
I9192_RS09255	COG1765	OsmC-like protein
I9192_RS09265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I9192_RS09270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9192_RS09280	COG1045	serine acetyltransferase
I9192_RS09290	COG0542	response to heat
I9192_RS09330	COG3293	Transposase
I9192_RS09350	COG0540	Belongs to the ATCase OTCase family
I9192_RS09380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_RS09390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I9192_RS09400	COG0583	DNA-binding transcription factor activity
I9192_RS09420	COG3340	Belongs to the peptidase S51 family
I9192_RS09445	COG1309	transcriptional regulator
I9192_RS09450	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS09465	COG0204	Acyl-transferase
I9192_RS09480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I9192_RS09490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I9192_RS09510	COG0477	Major facilitator Superfamily
I9192_RS09515	COG0729	surface antigen
I9192_RS09535	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_RS09555	COG4783	chaperone-mediated protein folding
I9192_RS09570	COG1610	YqeY-like protein
I9192_RS09600	COG0436	Aminotransferase
I9192_RS09605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9192_RS09610	COG0386	Belongs to the glutathione peroxidase family
I9192_RS09615	COG2207	Transcriptional regulator
I9192_RS09615	COG1917	Cupin 2, conserved barrel domain protein
I9192_RS09665	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I9192_RS09685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I9192_RS09710	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_RS09740	COG0012	GTP binding
I9192_RS09745	COG2011	ABC-type metal ion transport system permease component
I9192_RS09750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9192_RS09755	COG1464	Belongs to the NlpA lipoprotein family
I9192_RS09760	COG1464	Belongs to the NlpA lipoprotein family
I9192_RS09830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9192_RS09865	COG2707	UPF0756 membrane protein
I9192_RS09870	COG1959	2 iron, 2 sulfur cluster binding
I9192_RS09875	COG0492	ferredoxin-NADP+ reductase activity
I9192_RS09880	COG1187	pseudouridine synthase activity
I9192_RS09900	COG0802	atpase or kinase
I9192_RS09905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I9192_RS09915	COG1923	regulation of RNA biosynthetic process
I9192_RS09955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9192_RS09965	COG3178	'Phosphotransferase
I9192_RS09970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I9192_RS09980	COG1192	Involved in chromosome partitioning
I9192_RS09985	COG1475	DNA binding
I9192_RS09990	COG0811	peptide transport
I9192_RS10000	COG1132	(ABC) transporter
I9192_RS10005	COG1663	tetraacyldisaccharide 4'-kinase activity
I9192_RS10025	COG0084	hydrolase, TatD family'
I9192_RS10050	COG3156	type II secretion system protein K
I9192_RS10060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I9192_RS10070	COG0590	tRNA wobble adenosine to inosine editing
I9192_RS10080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I9192_RS10115	COG0284	orotidine-5'-phosphate decarboxylase activity
I9192_RS10120	COG2431	L-lysine efflux transmembrane transporter activity
I9192_RS10135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I9192_RS10140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I9192_RS10145	COG0569	domain protein
I9192_RS10160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9192_RS10165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I9192_RS10200	COG3706	GGDEF domain
I9192_RS10215	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I9192_RS10220	COG0542	response to heat
I9192_RS10225	COG0657	acetylesterase activity
I9192_RS10225	COG2755	lipolytic protein G-D-S-L family
I9192_RS10250	COG0583	DNA-binding transcription factor activity
I9192_RS10255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_RS10265	COG0583	DNA-binding transcription factor activity
I9192_RS10270	COG1960	acyl-CoA dehydrogenase activity
I9192_RS10275	COG2814	Major facilitator Superfamily
I9192_RS10325	COG0372	Belongs to the citrate synthase family
I9192_RS10330	COG3433	isochorismatase activity
I9192_RS10330	COG1535	isochorismatase
I9192_RS10350	COG0069	glutamate synthase activity
I9192_RS10365	COG2850	peptidyl-arginine hydroxylation
I9192_RS10370	COG0424	maF-like protein
I9192_RS10380	COG0126	phosphoglycerate kinase activity
I9192_RS10405	COG3196	Protein conserved in bacteria
I9192_RS10430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I9192_RS10440	COG0702	epimerase
I9192_RS10445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I9192_RS10475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I9192_RS10505	COG0316	Belongs to the HesB IscA family
I9192_RS10510	COG0822	iron-sulfur transferase activity
I9192_RS10520	COG1959	2 iron, 2 sulfur cluster binding
I9192_RS10535	COG0776	regulation of translation
I9192_RS10545	COG2207	Transcriptional regulator
I9192_RS10550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_RS10580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I9192_RS10585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9192_RS10615	COG1733	regulation of RNA biosynthetic process
I9192_RS10980	COG0583	DNA-binding transcription factor activity
I9192_RS10985	COG1380	Effector of murein hydrolase LrgA
I9192_RS10990	COG1346	cytolysis
I9192_RS10995	COG2814	Major facilitator Superfamily
I9192_RS11015	COG0596	Alpha beta hydrolase
I9192_RS11020	COG1448	Aminotransferase
I9192_RS11025	COG0488	(ABC) transporter
I9192_RS11060	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9192_RS11065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9192_RS11075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_RS11080	COG0697	spore germination
I9192_RS11130	COG0583	DNA-binding transcription factor activity
I9192_RS11155	COG3152	Membrane
I9192_RS11165	COG1294	oxidase, subunit
I9192_RS11170	COG1271	oxidase subunit
I9192_RS11180	COG2207	Transcriptional regulator
I9192_RS11185	COG1960	acyl-CoA dehydrogenase activity
I9192_RS11220	COG0583	DNA-binding transcription factor activity
I9192_RS11225	COG2814	Major facilitator Superfamily
I9192_RS11235	COG4774	siderophore transport
I9192_RS11245	COG3293	Transposase
I9192_RS11255	COG2207	Transcriptional regulator
I9192_RS11260	COG1881	PFAM PEBP family protein
I9192_RS11275	COG0477	Major facilitator Superfamily
I9192_RS11285	COG1024	Enoyl-CoA hydratase
I9192_RS11290	COG1960	acyl-CoA dehydrogenase activity
I9192_RS11295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_RS11315	COG1944	ATP diphosphatase activity
I9192_RS11330	COG0583	DNA-binding transcription factor activity
I9192_RS11335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_RS11340	COG4266	Belongs to the allantoicase family
I9192_RS11345	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I9192_RS11355	COG2351	hydroxyisourate hydrolase activity
I9192_RS11385	COG0804	urea catabolic process
I9192_RS11400	COG0829	nickel cation binding
I9192_RS11410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I9192_RS11415	COG0830	nickel cation binding
I9192_RS11425	COG0589	response to stress
I9192_RS11475	COG1960	acyl-CoA dehydrogenase activity
I9192_RS11480	COG1960	acyl-CoA dehydrogenase activity
I9192_RS11500	COG0509	glycine decarboxylation via glycine cleavage system
I9192_RS11525	COG3300	MHYT domain
I9192_RS11525	COG5001	Diguanylate cyclase
I9192_RS11555	COG0640	Transcriptional regulator
I9192_RS11570	COG3619	membrane
I9192_RS11575	COG3122	Protein conserved in bacteria
I9192_RS11590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I9192_RS11605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I9192_RS11645	COG2223	nitrite transmembrane transporter activity
I9192_RS11685	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS11700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9192_RS11705	COG2267	carboxylic ester hydrolase activity
I9192_RS11710	COG2453	phosphatase
I9192_RS11710	COG0671	phosphoesterase, PA-phosphatase related
I9192_RS11725	COG4589	Belongs to the CDS family
I9192_RS11780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I9192_RS11785	COG2937	Belongs to the GPAT DAPAT family
I9192_RS11790	COG0596	Alpha beta hydrolase
I9192_RS11790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_RS11790	COG2226	methyltransferase
I9192_RS11795	COG1309	transcriptional regulator
I9192_RS11825	COG0667	Aldo Keto reductase
I9192_RS11830	COG0583	DNA-binding transcription factor activity
I9192_RS11835	COG3293	Transposase
I9192_RS11885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9192_RS11890	COG0772	Belongs to the SEDS family
I9192_RS11900	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I9192_RS11910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I9192_RS11945	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_RS11945	COG1902	pentaerythritol trinitrate reductase activity
I9192_RS11965	COG2814	Major facilitator Superfamily
I9192_RS11970	COG0583	DNA-binding transcription factor activity
I9192_RS11980	COG4638	Rieske (2fe-2S)
I9192_RS11985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I9192_RS11990	COG0543	2 iron, 2 sulfur cluster binding
I9192_RS11990	COG0633	Ferredoxin
I9192_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS12000	COG3135	benzoate transporter
I9192_RS12030	COG0477	Major facilitator Superfamily
I9192_RS12040	COG3293	Transposase
I9192_RS12055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I9192_RS12065	COG1027	Aspartate ammonia-lyase
I9192_RS12070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9192_RS12125	COG0308	aminopeptidase N
I9192_RS12140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I9192_RS12150	COG1846	Transcriptional regulator
I9192_RS12190	COG0511	ligase activity, forming carbon-carbon bonds
I9192_RS12195	COG0439	Biotin carboxylase
I9192_RS12225	COG0730	response to heat
I9192_RS12230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9192_RS12250	COG1218	3'(2'),5'-bisphosphate nucleotidase
I9192_RS12260	COG1011	Hydrolase
I9192_RS12265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I9192_RS12270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I9192_RS12275	COG4221	oxidoreductase activity
I9192_RS12280	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_RS12285	COG2137	regulation of response to DNA damage stimulus
I9192_RS12305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_RS12315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_RS12325	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9192_RS12340	COG0575	Belongs to the CDS family
I9192_RS12345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I9192_RS12350	COG0233	cytoplasmic translational termination
I9192_RS12365	COG3852	Histidine kinase
I9192_RS12380	COG3753	Protein conserved in bacteria
I9192_RS12395	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9192_RS12400	COG4773	Receptor
I9192_RS12420	COG1304	FMN binding
I9192_RS12425	COG1132	(ABC) transporter
I9192_RS12430	COG1846	Transcriptional regulator
I9192_RS12445	COG2153	protein acetylation
I9192_RS12450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I9192_RS12480	COG1294	oxidase, subunit
I9192_RS12485	COG4890	Cyd operon protein YbgT
I9192_RS12540	COG2194	sulfuric ester hydrolase activity
I9192_RS12545	COG2119	membrane
I9192_RS12550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_RS12570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I9192_RS12580	COG3135	benzoate transporter
I9192_RS12585	COG0024	Methionine aminopeptidase
I9192_RS12590	COG1114	Component of the transport system for branched-chain amino acids
I9192_RS12610	COG1253	flavin adenine dinucleotide binding
I9192_RS12630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I9192_RS12640	COG0552	protein localization to endoplasmic reticulum
I9192_RS12645	COG0612	Peptidase, M16
I9192_RS12675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9192_RS12675	COG0517	IMP dehydrogenase activity
I9192_RS12685	COG0133	tryptophan synthase activity
I9192_RS12695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9192_RS12715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I9192_RS12745	COG0537	adenosine 5'-monophosphoramidase activity
I9192_RS12810	COG1454	alcohol dehydrogenase
I9192_RS12825	COG0824	Thioesterase
I9192_RS12870	COG0183	Belongs to the thiolase family
I9192_RS12880	COG1454	alcohol dehydrogenase
I9192_RS12895	COG3284	Transcriptional regulator
I9192_RS12915	COG0583	DNA-binding transcription factor activity
I9192_RS12935	COG1309	transcriptional regulator
I9192_RS12940	COG0519	Catalyzes the synthesis of GMP from XMP
I9192_RS12940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9192_RS12945	COG3042	response to heat
I9192_RS12955	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9192_RS12965	COG2353	YceI-like domain
I9192_RS12980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I9192_RS13000	COG1280	lysine exporter protein (LysE YggA)
I9192_RS13030	COG1254	Belongs to the acylphosphatase family
I9192_RS13035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I9192_RS13035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I9192_RS13065	COG0167	dihydroorotate dehydrogenase activity
I9192_RS13090	COG0778	Nitroreductase
I9192_RS13100	COG0513	Belongs to the DEAD box helicase family
I9192_RS13120	COG2363	Small membrane protein
I9192_RS13150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I9192_RS13155	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_RS13165	COG0659	secondary active sulfate transmembrane transporter activity
I9192_RS13175	COG4585	Histidine kinase
I9192_RS13185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9192_RS13190	COG1960	acyl-CoA dehydrogenase activity
I9192_RS13210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_RS13215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_RS13220	COG3781	membrane
I9192_RS13225	COG2890	protein-(glutamine-N5) methyltransferase activity
I9192_RS13245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_RS13250	COG4682	membrane
I9192_RS13280	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I9192_RS13285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I9192_RS13290	COG1845	cytochrome c oxidase, subunit III
I9192_RS13295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I9192_RS13315	COG0360	Binds together with S18 to 16S ribosomal RNA
I9192_RS13320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I9192_RS13330	COG0305	Participates in initiation and elongation during chromosome replication
I9192_RS13340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I9192_RS13360	COG1305	Transglutaminase-like
I9192_RS13370	COG2308	Evidence 4 Homologs of previously reported genes of
I9192_RS13410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I9192_RS13415	COG0138	bifunctional purine biosynthesis protein purh
I9192_RS13420	COG0151	Belongs to the GarS family
I9192_RS13430	COG1464	Belongs to the NlpA lipoprotein family
I9192_RS13435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9192_RS13440	COG2011	ABC-type metal ion transport system permease component
I9192_RS13450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9192_RS13545	COG3022	response to hydroperoxide
I9192_RS13555	COG4650	regulator
I9192_RS13560	COG1234	tRNA 3'-trailer cleavage
I9192_RS13570	COG1690	Belongs to the RtcB family
I9192_RS13580	COG0430	RNA-3'-phosphate cyclase activity
I9192_RS13600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I9192_RS13610	COG0693	protein deglycase activity
I9192_RS13620	COG1960	acyl-CoA dehydrogenase activity
I9192_RS13625	COG0616	signal peptide processing
I9192_RS13630	COG3293	Transposase
I9192_RS13635	COG1301	dicarboxylic acid transport
I9192_RS13640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I9192_RS13650	COG0573	inorganic phosphate transmembrane transporter activity
I9192_RS13665	COG4122	O-methyltransferase activity
I9192_RS13690	COG1137	ATPase activity
I9192_RS13695	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I9192_RS13705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I9192_RS13710	COG0517	IMP dehydrogenase activity
I9192_RS13710	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9192_RS13720	COG0427	acetyl-CoA hydrolase
I9192_RS13725	COG0183	Belongs to the thiolase family
I9192_RS13730	COG1960	acyl-CoA dehydrogenase activity
I9192_RS13780	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I9192_RS13805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS13820	COG1301	dicarboxylic acid transport
I9192_RS13845	COG0047	phosphoribosylformylglycinamidine synthase activity
I9192_RS13845	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I9192_RS13880	COG4771	TonB-dependent receptor
I9192_RS13915	COG0824	Thioesterase
I9192_RS13945	COG0823	Involved in the tonB-independent uptake of proteins
I9192_RS13970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9192_RS13990	COG0174	glutamine synthetase
I9192_RS14060	COG0512	Glutamine amidotransferase of anthranilate synthase
I9192_RS14065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9192_RS14085	COG0302	gtp cyclohydrolase
I9192_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS14120	COG1960	acyl-CoA dehydrogenase activity
I9192_RS14125	COG4302	ethanolamine ammonia-lyase activity
I9192_RS14130	COG4303	Ethanolamine ammonia lyase large subunit
I9192_RS14135	COG0531	amino acid
I9192_RS14155	COG3739	integral membrane protein
I9192_RS14170	COG1741	Belongs to the pirin family
I9192_RS14175	COG0235	Class ii aldolase
I9192_RS14190	COG2233	PERMEase
I9192_RS14195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS14200	COG0251	oxidation-reduction process
I9192_RS14205	COG1335	isochorismatase
I9192_RS14210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_RS14220	COG0596	Alpha beta hydrolase
I9192_RS14270	COG0864	Transcriptional regulator
I9192_RS14275	COG1733	regulation of RNA biosynthetic process
I9192_RS14280	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_RS14285	COG0439	Biotin carboxylase
I9192_RS14305	COG0583	DNA-binding transcription factor activity
I9192_RS14310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I9192_RS14320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_RS14325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I9192_RS14330	COG4149	molybdate abc transporter
I9192_RS14335	COG0725	ABC transporter, periplasmic molybdate-binding protein
I9192_RS14340	COG0303	'Molybdopterin
I9192_RS14345	COG0315	cyclic pyranopterin monophosphate synthase activity
I9192_RS14345	COG0521	Mo-molybdopterin cofactor biosynthetic process
I9192_RS14350	COG0314	molybdopterin synthase activity
I9192_RS14360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I9192_RS14370	COG0243	molybdopterin cofactor binding
I9192_RS14375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_RS14380	COG2146	nitrite reductase [NAD(P)H] activity
I9192_RS14380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_RS14385	COG2223	nitrite transmembrane transporter activity
I9192_RS14395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_RS14395	COG1116	anion transmembrane transporter activity
I9192_RS14400	COG4774	siderophore transport
I9192_RS14405	COG1846	Transcriptional regulator
I9192_RS14450	COG3121	Chaperone
I9192_RS14455	COG3539	Fimbrial protein
I9192_RS14475	COG1113	amino acid transport
I9192_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS14490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9192_RS14575	COG2072	flavoprotein involved in K transport
I9192_RS14595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I9192_RS14600	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS14650	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS14670	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS14675	COG3210	domain, Protein
I9192_RS14675	COG3210	domain, Protein
I9192_RS14680	COG2831	hemolysin activation secretion protein
I9192_RS14695	COG0582	viral genome integration into host DNA
I9192_RS14730	COG1230	cation diffusion facilitator family transporter
I9192_RS14745	COG2814	Major facilitator Superfamily
I9192_RS14845	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_RS14845	COG1902	pentaerythritol trinitrate reductase activity
I9192_RS14855	COG0277	FAD linked oxidase domain protein
I9192_RS14865	COG2186	Transcriptional regulator
I9192_RS14875	COG0697	spore germination
I9192_RS14880	COG0583	DNA-binding transcription factor activity
I9192_RS14920	COG1960	acyl-CoA dehydrogenase activity
I9192_RS14955	COG0154	amidase activity
I9192_RS14975	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I9192_RS14985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9192_RS14995	COG0280	phosphate acetyltransferase
I9192_RS14995	COG0281	malic enzyme
I9192_RS15030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I9192_RS15035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_RS15040	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9192_RS15055	COG2351	hydroxyisourate hydrolase activity
I9192_RS15065	COG1686	Belongs to the peptidase S11 family
I9192_RS15070	COG1252	NADH dehydrogenase
I9192_RS15075	COG1047	Peptidyl-prolyl cis-trans
I9192_RS15080	COG0415	Belongs to the DNA photolyase family
I9192_RS15095	COG0583	DNA-binding transcription factor activity
I9192_RS15100	COG0251	oxidation-reduction process
I9192_RS15110	COG0667	Aldo Keto reductase
I9192_RS15120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I9192_RS15135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I9192_RS15140	COG0571	ribonuclease III activity
I9192_RS15165	COG0463	Glycosyl transferase, family 2
I9192_RS15170	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I9192_RS15175	COG0671	phosphoesterase, PA-phosphatase related
I9192_RS15185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9192_RS15225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I9192_RS15230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I9192_RS15235	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I9192_RS15245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I9192_RS15250	COG4208	sulfate ABC transporter
I9192_RS15255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I9192_RS15260	COG0583	DNA-binding transcription factor activity
I9192_RS15280	COG0602	queuosine metabolic process
I9192_RS15285	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I9192_RS15300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9192_RS15310	COG0583	DNA-binding transcription factor activity
I9192_RS15320	COG0625	glutathione transferase activity
I9192_RS15335	COG1051	belongs to the nudix hydrolase family
I9192_RS15335	COG1056	cytidyltransferase-related domain
I9192_RS15340	COG1024	Enoyl-CoA hydratase
I9192_RS15345	COG0778	Nitroreductase
I9192_RS15350	COG3323	Protein of unknown function (DUF1653)
I9192_RS15350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9192_RS15395	COG1280	lysine exporter protein (LysE YggA)
I9192_RS15400	COG1522	sequence-specific DNA binding
I9192_RS15425	COG2234	aminopeptidase activity
I9192_RS15435	COG3384	dioxygenase
I9192_RS15450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9192_RS15455	COG2878	Part of a membrane complex involved in electron transport
I9192_RS15460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I9192_RS15490	COG0768	penicillin binding
I9192_RS15495	COG0742	ribosomal rna small subunit methyltransferase
I9192_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS15520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I9192_RS15530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_RS15545	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I9192_RS15550	COG1053	succinate dehydrogenase
I9192_RS15555	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I9192_RS15560	COG2009	succinate dehydrogenase
I9192_RS15595	COG2072	flavoprotein involved in K transport
I9192_RS15600	COG0300	oxidoreductase activity
I9192_RS15625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I9192_RS15625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9192_RS15645	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I9192_RS15650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9192_RS15655	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I9192_RS15675	COG0505	Belongs to the CarA family
I9192_RS15680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I9192_RS15690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I9192_RS15700	COG1113	amino acid transport
I9192_RS15710	COG0625	glutathione transferase activity
I9192_RS15725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_RS15745	COG1024	Enoyl-CoA hydratase
I9192_RS15770	COG2321	neutral zinc metallopeptidase
I9192_RS15775	COG2354	Protein conserved in bacteria
I9192_RS15805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I9192_RS15810	COG1773	rubredoxin
I9192_RS15815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9192_RS15825	COG0583	DNA-binding transcription factor activity
I9192_RS15840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9192_RS15850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I9192_RS15855	COG4181	ATPase activity
I9192_RS15880	COG2357	RelA SpoT domain protein
I9192_RS15975	COG1783	phage Terminase large subunit
I9192_RS16020	COG0305	Participates in initiation and elongation during chromosome replication
I9192_RS16110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I9192_RS16125	COG0424	maF-like protein
I9192_RS16130	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I9192_RS16135	COG1792	Involved in formation and maintenance of cell shape
I9192_RS16140	COG1077	Cell shape determining protein MreB Mrl
I9192_RS16145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9192_RS16155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9192_RS16175	COG2318	DinB family
I9192_RS16190	COG3590	peptidase
I9192_RS16195	COG0583	DNA-binding transcription factor activity
I9192_RS16225	COG0583	DNA-binding transcription factor activity
I9192_RS16230	COG4948	Mandelate Racemase Muconate Lactonizing
I9192_RS16235	COG4829	muconolactone delta-isomerase
I9192_RS16245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9192_RS16250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9192_RS16255	COG0183	Belongs to the thiolase family
I9192_RS16260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_RS16295	COG2871	sodium ion transport
I9192_RS16310	COG0789	Transcriptional regulator
I9192_RS16320	COG4221	oxidoreductase activity
I9192_RS16325	COG1902	pentaerythritol trinitrate reductase activity
I9192_RS16325	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9192_RS16335	COG0523	cobalamin synthesis protein
I9192_RS16350	COG3539	Fimbrial protein
I9192_RS16380	COG3539	Fimbrial protein
I9192_RS16395	COG3539	Fimbrial protein
I9192_RS16405	COG3121	Chaperone
I9192_RS16420	COG3539	Fimbrial protein
I9192_RS16440	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS16445	COG4638	Rieske (2fe-2S)
I9192_RS16450	COG0657	acetylesterase activity
I9192_RS16460	COG0473	3-isopropylmalate dehydrogenase activity
I9192_RS16465	COG0583	DNA-binding transcription factor activity
I9192_RS16485	COG1063	alcohol dehydrogenase
I9192_RS16495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9192_RS16500	COG0508	dehydrogenase complex catalyzes the overall conversion of
I9192_RS16505	COG0022	dehydrogenase e1 component
I9192_RS16510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I9192_RS16515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9192_RS16525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9192_RS16530	COG3135	benzoate transporter
I9192_RS16540	COG5002	protein histidine kinase activity
I9192_RS16550	COG0745	RESPONSE REGULATOR receiver
I9192_RS16555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS16560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_RS16580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I9192_RS16655	COG0505	Belongs to the CarA family
I9192_RS16660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9192_RS16670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I9192_RS16675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9192_RS16680	COG3706	GGDEF domain
I9192_RS16700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9192_RS16705	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS16715	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9192_RS16720	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS16725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9192_RS16730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS16735	COG2267	carboxylic ester hydrolase activity
I9192_RS16755	COG4774	siderophore transport
I9192_RS16760	COG4607	ABC-type enterochelin transport system periplasmic component
I9192_RS16765	COG4604	ABC transporter, ATP-binding protein
I9192_RS16770	COG4605	iron ion homeostasis
I9192_RS16775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I9192_RS16785	COG1132	(ABC) transporter
I9192_RS16785	COG2375	cellular response to nickel ion
I9192_RS16800	COG0789	Transcriptional regulator
I9192_RS16815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9192_RS16820	COG2771	luxR family
I9192_RS16840	COG1733	regulation of RNA biosynthetic process
I9192_RS16845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9192_RS16850	COG1414	Transcriptional regulator
I9192_RS16865	COG2985	domain, Protein
I9192_RS16880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_RS16885	COG3328	transposase activity
I9192_RS16890	COG0431	NADPH-dependent FMN reductase
I9192_RS16895	COG0798	PFAM Bile acid sodium symporter
I9192_RS16905	COG0640	Transcriptional regulator
I9192_RS16930	COG1595	DNA-templated transcription, initiation
I9192_RS16940	COG3220	belongs to the UPF0276 family
I9192_RS16965	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
I9192_RS17000	COG4774	siderophore transport
I9192_RS17010	COG1802	Transcriptional regulator
I9192_RS17035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9192_RS17130	COG0582	viral genome integration into host DNA
I9192_RS17140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I9192_RS17145	COG0242	peptide deformylase activity
I9192_RS17150	COG0477	Major facilitator Superfamily
I9192_RS17155	COG3706	GGDEF domain
I9192_RS17170	COG1585	Membrane protein implicated in regulation of membrane protease activity
I9192_RS17175	COG2268	Band 7 protein
I9192_RS17185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9192_RS17190	COG1309	transcriptional regulator
I9192_RS17210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I9192_RS17215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I9192_RS17230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I9192_RS17235	COG0601	transmembrane transport
I9192_RS17245	COG4166	transmembrane transport
I9192_RS17250	COG4166	transmembrane transport
I9192_RS17280	COG0590	tRNA wobble adenosine to inosine editing
I9192_RS17285	COG2824	Alkylphosphonate utilization operon protein PhnA
I9192_RS17315	COG1408	metallophosphoesterase
I9192_RS17320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9192_RS17330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I9192_RS17370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9192_RS17375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I9192_RS17380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I9192_RS17390	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I9192_RS17395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I9192_RS17405	COG0625	glutathione transferase activity
I9192_RS17410	COG2969	positive regulation of protein catabolic process
I9192_RS17435	COG5002	protein histidine kinase activity
I9192_RS17435	COG3447	MASE1 domain protein
I9192_RS17435	COG5001	Diguanylate cyclase
I9192_RS17475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I9192_RS17480	COG0354	folic acid binding
I9192_RS17495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9192_RS17545	COG1902	pentaerythritol trinitrate reductase activity
I9192_RS17550	COG4772	TonB-dependent receptor
I9192_RS17555	COG3659	wide pore channel activity
I9192_RS17565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9192_RS17580	COG1970	mechanosensitive ion channel activity
I9192_RS17585	COG1217	gtp-binding protein TYPA
I9192_RS17590	COG2233	PERMEase
I9192_RS17600	COG0833	amino acid
I9192_RS17605	COG1690	Belongs to the RtcB family
I9192_RS17630	COG0183	Belongs to the thiolase family
I9192_RS17685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9192_RS17690	COG0523	cobalamin synthesis protein
I9192_RS17705	COG0204	Acyl-transferase
I9192_RS17720	COG1280	lysine exporter protein (LysE YggA)
I9192_RS17725	COG1674	ftsk spoiiie
I9192_RS17725	COG0531	amino acid
I9192_RS17730	COG0492	ferredoxin-NADP+ reductase activity
I9192_RS17735	COG0500	methyltransferase
I9192_RS17740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I9192_RS17750	COG0456	acetyltransferase
I9192_RS17775	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I9192_RS17785	COG0714	Associated with various cellular activities
I9192_RS17795	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I9192_RS17805	COG3831	ATPase activity
I9192_RS17815	COG1981	membrane
I9192_RS17825	COG1113	amino acid transport
I9192_RS17830	COG0251	oxidation-reduction process
I9192_RS17855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9192_RS17855	COG0352	thiamine-phosphate diphosphorylase activity
I9192_RS17855	COG0351	phosphomethylpyrimidine kinase
I9192_RS17870	COG1280	lysine exporter protein (LysE YggA)
I9192_RS17875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I9192_RS17885	COG2076	Multidrug Resistance protein
I9192_RS17900	COG2132	Multicopper oxidase
I9192_RS17910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I9192_RS17920	COG4269	membrane
I9192_RS18000	COG2826	transposase and inactivated derivatives, IS30 family
I9192_RS18025	COG1968	undecaprenyl-diphosphatase activity
I9192_RS18030	COG1214	PFAM Peptidase M22, glycoprotease
I9192_RS18035	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9192_RS18040	COG0494	nUDIX hydrolase
I9192_RS18095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I9192_RS18105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I9192_RS18130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9192_RS18135	COG0765	amino acid transport
I9192_RS18140	COG0765	amino acid transport
I9192_RS18145	COG1126	abc transporter atp-binding protein
I9192_RS18170	COG4716	Myosin-crossreactive antigen
I9192_RS18185	COG2226	methyltransferase
I9192_RS18200	COG1309	transcriptional regulator
I9192_RS18215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I9192_RS18220	COG2081	HI0933 family
I9192_RS18235	COG0668	transmembrane transport
I9192_RS18250	COG2814	Major facilitator Superfamily
I9192_RS18255	COG1289	transmembrane transporter activity
I9192_RS18265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I9192_RS18320	COG2832	Protein of unknown function (DUF454)
I9192_RS18340	COG0793	Belongs to the peptidase S41A family
I9192_RS18365	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I9192_RS18370	COG0857	belongs to the CobB CobQ family
I9192_RS18370	COG0280	phosphate acetyltransferase
I9192_RS18415	COG0740	serine-type endopeptidase activity
I9192_RS18425	COG4774	siderophore transport
I9192_RS18430	COG4774	siderophore transport
I9192_RS18435	COG3128	pkhd-type hydroxylase
I9192_RS18445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I9192_RS18455	COG2813	Specifically methylates the guanine in position
I9192_RS18455	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9192_RS18480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I9192_RS18495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9192_RS18535	COG3878	Protein conserved in bacteria
I9192_RS18540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I9192_RS18600	COG2199	diguanylate cyclase activity
I9192_RS18635	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I9192_RS18650	COG0450	alkyl hydroperoxide reductase
I9192_RS18655	COG1652	LysM domain
I9192_RS18660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9192_RS18665	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS18680	COG1399	metal-binding, possibly nucleic acid-binding protein
I9192_RS18685	COG3101	peptidyl-lysine hydroxylation
I9192_RS18690	COG0009	L-threonylcarbamoyladenylate synthase
I9192_RS18695	COG3713	MltA-interacting MipA family protein
I9192_RS18715	COG0285	dihydrofolate synthase activity
I9192_RS18720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I9192_RS18760	COG0183	Belongs to the thiolase family
I9192_RS18770	COG0456	acetyltransferase
I9192_RS18775	COG0454	-acetyltransferase
I9192_RS18780	COG2207	Transcriptional regulator
I9192_RS18785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I9192_RS18800	COG1051	belongs to the nudix hydrolase family
I9192_RS18815	COG3422	double-strand break repair
I9192_RS18830	COG4106	trans-aconitate 2-methyltransferase activity
I9192_RS18845	COG2267	carboxylic ester hydrolase activity
I9192_RS18855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9192_RS18865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I9192_RS18880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I9192_RS18890	COG1196	nuclear chromosome segregation
I9192_RS18900	COG0730	response to heat
I9192_RS18915	COG0625	glutathione transferase activity
I9192_RS18920	COG3545	Serine hydrolase
I9192_RS18925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I9192_RS18935	COG3293	Transposase
I9192_RS18940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9192_RS19045	COG1011	Hydrolase
I9192_RS19050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9192_RS19070	COG1272	protein, Hemolysin III
I9192_RS19075	COG0477	Major facilitator Superfamily
I9192_RS19080	COG0564	pseudouridine synthase activity
I9192_RS19085	COG4770	biotin carboxylase activity
I9192_RS19090	COG1024	Enoyl-CoA hydratase
I9192_RS19095	COG1960	acyl-CoA dehydrogenase activity
I9192_RS19100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I9192_RS19105	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS19125	COG1960	acyl-CoA dehydrogenase activity
I9192_RS19130	COG1960	acyl-CoA dehydrogenase activity
I9192_RS19135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9192_RS19175	COG1183	phosphatidylcholine synthase activity
I9192_RS19180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I9192_RS19200	COG0039	L-malate dehydrogenase activity
I9192_RS19210	COG0741	lytic transglycosylase activity
I9192_RS19210	COG0739	heme binding
I9192_RS19210	COG1196	nuclear chromosome segregation
I9192_RS19215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I9192_RS19220	COG1702	phosphate starvation-inducible protein PhoH
I9192_RS19230	COG0613	PHP domain protein
I9192_RS19240	COG2350	Protein conserved in bacteria
I9192_RS19255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I9192_RS19260	COG1666	GTP binding
I9192_RS19275	COG1607	acyl-coa hydrolase
I9192_RS19300	COG0402	S-adenosylhomocysteine deaminase activity
I9192_RS19305	COG2267	carboxylic ester hydrolase activity
I9192_RS19310	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9192_RS19345	COG0788	formyltetrahydrofolate deformylase activity
I9192_RS19370	COG4651	solute:proton antiporter activity
I9192_RS19370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I9192_RS19395	COG1929	Belongs to the glycerate kinase type-1 family
I9192_RS19430	COG1733	regulation of RNA biosynthetic process
I9192_RS19435	COG1028	Short-chain dehydrogenase reductase Sdr
I9192_RS19445	COG4770	biotin carboxylase activity
I9192_RS19465	COG1914	H( )-stimulated, divalent metal cation uptake system
I9192_RS19470	COG0583	DNA-binding transcription factor activity
I9192_RS19475	COG2900	Belongs to the SlyX family
I9192_RS19480	COG0488	(ABC) transporter
I9192_RS19525	COG1560	Kdo2-lipid A biosynthetic process
I9192_RS19560	COG0252	asparaginase activity
I9192_RS19575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I9192_RS19585	COG0473	3-isopropylmalate dehydrogenase activity
I9192_RS19600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I9192_RS19615	COG0583	DNA-binding transcription factor activity
I9192_RS19630	COG0494	nUDIX hydrolase
I9192_RS19655	COG1960	acyl-CoA dehydrogenase activity
I9192_RS19665	COG0753	catalase activity
I9192_RS19705	COG0583	DNA-binding transcription factor activity
I9192_RS19720	COG2378	regulation of single-species biofilm formation
I9192_RS19725	COG0546	phosphoglycolate phosphatase activity
I9192_RS19735	COG1530	ribonuclease E activity
I9192_RS19740	COG0318	PFAM AMP-dependent synthetase and ligase
I9192_RS19770	COG1983	PspC domain protein
I9192_RS19775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I9192_RS19775	COG0517	IMP dehydrogenase activity
I9192_RS19775	COG0617	tRNA 3'-terminal CCA addition
I9192_RS19790	COG0277	FAD linked oxidase domain protein
I9192_RS19800	COG0752	glycyl-tRNA synthetase alpha subunit
I9192_RS19825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9192_RS19870	COG2226	methyltransferase
I9192_RS19885	COG0628	permease
I9192_RS19890	COG2032	superoxide dismutase activity
I9192_RS19905	COG1289	transmembrane transporter activity
I9192_RS19915	COG2814	Major facilitator Superfamily
I9192_RS19940	COG1181	Belongs to the D-alanine--D-alanine ligase family
I9192_RS19955	COG0277	FAD linked oxidase domain protein
I9192_RS19960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I9192_RS19965	COG5006	permease, DMT superfamily
I9192_RS19975	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9192_RS20000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I9192_RS20005	COG5380	lipid catabolic process
I9192_RS20010	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_RS20020	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_RS20025	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9192_RS20030	COG0335	large ribosomal subunit rRNA binding
I9192_RS20040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I9192_RS20045	COG0228	four-way junction DNA binding
I9192_RS20090	COG0194	GDP metabolic process
I9192_RS20095	COG1758	RNA polymerase activity
I9192_RS20100	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9192_RS20120	COG3307	-O-antigen
I9192_RS20150	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9192_RS20155	COG1704	LemA family
I9192_RS20160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I9192_RS20165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I9192_RS20170	COG0195	Participates in both transcription termination and antitermination
I9192_RS20175	COG0779	Required for maturation of 30S ribosomal subunits
I9192_RS20225	COG0237	dephospho-CoA kinase activity
I9192_RS20235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9192_RS20240	COG3123	guanosine phosphorylase activity
I9192_RS20245	COG0497	DNA recombination
I9192_RS20255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I9192_RS20275	COG1289	transmembrane transporter activity
I9192_RS20285	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9192_RS20295	COG1132	(ABC) transporter
I9192_RS20315	COG4974	Belongs to the 'phage' integrase family
I9192_RS20330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I9192_RS20335	COG1686	Belongs to the peptidase S11 family
I9192_RS20340	COG2197	response regulator
I9192_RS20355	COG0793	Belongs to the peptidase S41A family
I9192_RS20360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I9192_RS20365	COG0795	lipopolysaccharide-transporting ATPase activity
I9192_RS20370	COG0795	lipopolysaccharide-transporting ATPase activity
I9192_RS20405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9192_RS20440	COG1024	Enoyl-CoA hydratase
I9192_RS20440	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9192_RS20445	COG0183	Belongs to the thiolase family
I9192_RS20480	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I9192_RS20495	COG0326	Molecular chaperone. Has ATPase activity
I9192_RS20520	COG2056	Na+-H+ antiporter family
I9192_RS20550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I9192_RS20555	COG0085	RNA polymerase activity
I9192_RS20570	COG0081	regulation of translation
I9192_RS20585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I9192_RS20630	COG1716	ATPase activity
I9192_RS20675	COG0181	hydroxymethylbilane synthase activity
I9192_RS20685	COG0745	RESPONSE REGULATOR receiver
I9192_RS20685	COG2972	Histidine kinase
I9192_RS20690	COG0165	Argininosuccinate lyase
I9192_RS20710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I9192_RS20730	COG3158	transport of potassium into the cell
I9192_RS20780	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I9192_RS20790	COG1335	isochorismatase
I9192_RS20795	COG0583	DNA-binding transcription factor activity
I9192_RS20810	COG2207	Transcriptional regulator
I9192_RS20810	COG3708	Transcriptional regulator
I9192_RS20820	COG0629	single-stranded DNA binding
I9192_RS20825	COG2814	Major facilitator Superfamily
I9192_RS20835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9192_RS20835	COG0351	phosphomethylpyrimidine kinase
I9192_RS20835	COG0352	thiamine-phosphate diphosphorylase activity
I9192_RS20845	COG2814	Major facilitator Superfamily
I9192_RS20860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9192_RS20865	COG2267	carboxylic ester hydrolase activity
I9192_RS20910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I9192_RS20915	COG0259	pyridoxamine-phosphate oxidase activity
I9192_RS20935	COG0426	domain, Protein
I9192_RS20935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS20940	COG2119	membrane
I9192_RS20980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I9192_RS20990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9192_RS21000	COG0189	ligase activity
I9192_RS21005	COG3385	transposase activity
I9192_RS21015	COG2226	methyltransferase
I9192_RS21020	COG2720	vancomycin resistance protein
I9192_RS21035	COG0708	Exodeoxyribonuclease III
I9192_RS21040	COG1393	Belongs to the ArsC family
I9192_RS21060	COG3706	GGDEF domain
I9192_RS21130	COG3150	esterase
I9192_RS21150	COG2918	glutathione biosynthetic process
I9192_RS21170	COG2733	membrane
I9192_RS21200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9192_RS21265	COG0436	Aminotransferase
I9192_RS21270	COG0534	Mate efflux family protein
I9192_RS21335	COG0560	Phosphoserine phosphatase
I9192_RS21335	COG3830	Belongs to the UPF0237 family
I9192_RS21350	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I9192_RS21360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I9192_RS21365	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I9192_RS21375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I9192_RS21380	COG1230	cation diffusion facilitator family transporter
I9192_RS21385	COG0640	Transcriptional regulator
I9192_RS21400	COG1683	Conserved Protein
I9192_RS21405	COG0385	Bile acid
I9192_RS21410	COG1335	isochorismatase
I9192_RS21415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9192_RS21440	COG0633	Ferredoxin
I9192_RS21465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I9192_RS21470	COG2819	hydrolase of the alpha beta superfamily
I9192_RS21475	COG2983	Belongs to the UPF0260 family
I9192_RS21480	COG5487	UPF0391 membrane protein
I9192_RS21495	COG1194	a g-specific adenine glycosylase
I9192_RS21500	COG0739	heme binding
I9192_RS21510	COG2818	Glycosylase
I9192_RS21515	COG1064	alcohol dehydrogenase
I9192_RS21530	COG0583	DNA-binding transcription factor activity
I9192_RS21535	COG0656	L-ascorbic acid biosynthetic process
I9192_RS21540	COG2814	Major facilitator Superfamily
I9192_RS21580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9192_RS21585	COG1309	transcriptional regulator
I9192_RS21590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9192_RS21595	COG2233	PERMEase
I9192_RS21610	COG0196	riboflavin kinase activity
I9192_RS21615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I9192_RS21620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I9192_RS21625	COG1047	Peptidyl-prolyl cis-trans
I9192_RS21630	COG1794	racemase activity, acting on amino acids and derivatives
I9192_RS21645	COG0174	glutamine synthetase
I9192_RS21665	COG0129	dihydroxy-acid dehydratase activity
I9192_RS21680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I9192_RS21695	COG0733	neurotransmitter:sodium symporter activity
I9192_RS21700	COG3738	Protein conserved in bacteria
I9192_RS21705	COG1012	belongs to the aldehyde dehydrogenase family
I9192_RS21750	COG0737	Belongs to the 5'-nucleotidase family
I9192_RS21755	COG2175	clavaminate synthase activity
I9192_RS21760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9192_RS21765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I9192_RS21770	COG4521	taurine ABC transporter
I9192_RS21790	COG0443	Heat shock 70 kDa protein
I9192_RS21830	COG2951	lytic endotransglycosylase activity
I9192_RS21835	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I9192_RS21855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9192_RS21875	COG2388	GCN5-related N-acetyl-transferase
I9192_RS21880	COG2388	GCN5-related N-acetyl-transferase
I9192_RS21885	COG2814	Major facilitator Superfamily
I9192_RS21890	COG1335	isochorismatase
I9192_RS21895	COG0861	Integral membrane protein TerC family
I9192_RS21910	COG0754	glutathionylspermidine amidase activity
I9192_RS21920	COG0402	S-adenosylhomocysteine deaminase activity
I9192_RS21930	COG2261	transglycosylase associated protein
I9192_RS21940	COG1230	cation diffusion facilitator family transporter
I9192_RS21965	COG0706	membrane insertase activity
I9192_RS21970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I9192_RS21975	COG0594	ribonuclease P activity
I9192_RS22005	COG2801	Transposase and inactivated derivatives
I9192_RS22010	COG3173	Aminoglycoside phosphotransferase
I9192_RS22015	COG0488	(ABC) transporter
I9192_RS22020	COG2801	Transposase and inactivated derivatives
I9192_RS22035	COG2801	Transposase and inactivated derivatives
I9192_RS22040	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9192_RS22045	COG3657	addiction module killer protein
I9192_RS22060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I9192_RS22135	COG1475	DNA binding
I9192_RS22140	COG1192	Involved in chromosome partitioning
I9192_RS22175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9192_RS22190	COG1570	exodeoxyribonuclease VII activity