locus-tag	class	description
I9190_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I9190_RS00010	COG0592	DNA-directed DNA polymerase activity
I9190_RS00020	COG0187	DNA topoisomerase II activity
I9190_RS00030	COG0488	(ABC) transporter
I9190_RS00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I9190_RS00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I9190_RS00050	COG0596	Alpha beta hydrolase
I9190_RS00070	COG0657	acetylesterase activity
I9190_RS00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I9190_RS00115	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS00120	COG3738	Protein conserved in bacteria
I9190_RS00125	COG0733	neurotransmitter:sodium symporter activity
I9190_RS00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I9190_RS00155	COG0129	dihydroxy-acid dehydratase activity
I9190_RS00175	COG0174	glutamine synthetase
I9190_RS00190	COG1794	racemase activity, acting on amino acids and derivatives
I9190_RS00210	COG1047	Peptidyl-prolyl cis-trans
I9190_RS00215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I9190_RS00220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I9190_RS00225	COG0196	riboflavin kinase activity
I9190_RS00240	COG2233	PERMEase
I9190_RS00245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I9190_RS00250	COG1309	transcriptional regulator
I9190_RS00255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS00295	COG2814	Major facilitator Superfamily
I9190_RS00300	COG0656	L-ascorbic acid biosynthetic process
I9190_RS00305	COG0583	DNA-binding transcription factor activity
I9190_RS00320	COG1064	alcohol dehydrogenase
I9190_RS00325	COG2818	Glycosylase
I9190_RS00335	COG0739	heme binding
I9190_RS00340	COG1194	a g-specific adenine glycosylase
I9190_RS00355	COG5487	UPF0391 membrane protein
I9190_RS00360	COG2983	Belongs to the UPF0260 family
I9190_RS00365	COG2819	hydrolase of the alpha beta superfamily
I9190_RS00370	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I9190_RS00395	COG0633	Ferredoxin
I9190_RS00420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9190_RS00425	COG1335	isochorismatase
I9190_RS00430	COG0385	Bile acid
I9190_RS00435	COG1683	Conserved Protein
I9190_RS00450	COG0640	Transcriptional regulator
I9190_RS00455	COG1230	cation diffusion facilitator family transporter
I9190_RS00565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I9190_RS00575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I9190_RS00580	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I9190_RS00590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I9190_RS00605	COG3830	Belongs to the UPF0237 family
I9190_RS00605	COG0560	Phosphoserine phosphatase
I9190_RS00670	COG0534	Mate efflux family protein
I9190_RS00675	COG0436	Aminotransferase
I9190_RS00730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS00760	COG2733	membrane
I9190_RS00780	COG2918	glutathione biosynthetic process
I9190_RS00800	COG3150	esterase
I9190_RS00875	COG3706	GGDEF domain
I9190_RS00895	COG1393	Belongs to the ArsC family
I9190_RS00900	COG0708	Exodeoxyribonuclease III
I9190_RS00915	COG2720	vancomycin resistance protein
I9190_RS00920	COG2226	methyltransferase
I9190_RS00930	COG0189	ligase activity
I9190_RS00940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9190_RS00950	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I9190_RS00990	COG2119	membrane
I9190_RS00995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS00995	COG0426	domain, Protein
I9190_RS01015	COG0259	pyridoxamine-phosphate oxidase activity
I9190_RS01020	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I9190_RS01065	COG2267	carboxylic ester hydrolase activity
I9190_RS01070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I9190_RS01085	COG2814	Major facilitator Superfamily
I9190_RS01095	COG0351	phosphomethylpyrimidine kinase
I9190_RS01095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9190_RS01095	COG0352	thiamine-phosphate diphosphorylase activity
I9190_RS01105	COG2814	Major facilitator Superfamily
I9190_RS01110	COG0629	single-stranded DNA binding
I9190_RS01140	COG2271	Major facilitator Superfamily
I9190_RS01155	COG0583	DNA-binding transcription factor activity
I9190_RS01160	COG1335	isochorismatase
I9190_RS01170	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
I9190_RS01340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_RS01360	COG0582	viral genome integration into host DNA
I9190_RS01370	COG3158	transport of potassium into the cell
I9190_RS01390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I9190_RS01410	COG0165	Argininosuccinate lyase
I9190_RS01415	COG0745	RESPONSE REGULATOR receiver
I9190_RS01415	COG2972	Histidine kinase
I9190_RS01425	COG0181	hydroxymethylbilane synthase activity
I9190_RS01515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I9190_RS01530	COG0081	regulation of translation
I9190_RS01545	COG0085	RNA polymerase activity
I9190_RS01550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I9190_RS01580	COG2056	Na+-H+ antiporter family
I9190_RS01595	COG0326	Molecular chaperone. Has ATPase activity
I9190_RS01610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I9190_RS01685	COG0183	Belongs to the thiolase family
I9190_RS01690	COG1024	Enoyl-CoA hydratase
I9190_RS01690	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_RS01725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9190_RS01760	COG0795	lipopolysaccharide-transporting ATPase activity
I9190_RS01765	COG0795	lipopolysaccharide-transporting ATPase activity
I9190_RS01770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I9190_RS01775	COG0793	Belongs to the peptidase S41A family
I9190_RS01790	COG2197	response regulator
I9190_RS01795	COG1686	Belongs to the peptidase S11 family
I9190_RS01810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I9190_RS01825	COG4974	Belongs to the 'phage' integrase family
I9190_RS01845	COG1132	(ABC) transporter
I9190_RS01855	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_RS01865	COG1289	transmembrane transporter activity
I9190_RS01885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I9190_RS01895	COG0497	DNA recombination
I9190_RS01900	COG3123	guanosine phosphorylase activity
I9190_RS01905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9190_RS01915	COG0237	dephospho-CoA kinase activity
I9190_RS01965	COG0779	Required for maturation of 30S ribosomal subunits
I9190_RS01970	COG0195	Participates in both transcription termination and antitermination
I9190_RS01975	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I9190_RS01980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I9190_RS01985	COG1704	LemA family
I9190_RS01990	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9190_RS02080	COG3307	-O-antigen
I9190_RS02095	COG3307	-O-antigen
I9190_RS02115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_RS02120	COG1758	RNA polymerase activity
I9190_RS02125	COG0194	GDP metabolic process
I9190_RS02135	COG4969	Belongs to the N-Me-Phe pilin family
I9190_RS02170	COG4969	Belongs to the N-Me-Phe pilin family
I9190_RS02205	COG0228	four-way junction DNA binding
I9190_RS02210	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I9190_RS02220	COG0335	large ribosomal subunit rRNA binding
I9190_RS02230	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I9190_RS02245	COG5380	lipid catabolic process
I9190_RS02250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I9190_RS02275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9190_RS02285	COG5006	permease, DMT superfamily
I9190_RS02290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I9190_RS02295	COG0277	FAD linked oxidase domain protein
I9190_RS02335	COG2814	Major facilitator Superfamily
I9190_RS02345	COG1289	transmembrane transporter activity
I9190_RS02360	COG2032	superoxide dismutase activity
I9190_RS02365	COG0628	permease
I9190_RS02380	COG2226	methyltransferase
I9190_RS02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9190_RS02450	COG0752	glycyl-tRNA synthetase alpha subunit
I9190_RS02460	COG0277	FAD linked oxidase domain protein
I9190_RS02475	COG0517	IMP dehydrogenase activity
I9190_RS02475	COG0617	tRNA 3'-terminal CCA addition
I9190_RS02475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I9190_RS02480	COG1983	PspC domain protein
I9190_RS02510	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_RS02515	COG1530	ribonuclease E activity
I9190_RS02525	COG0546	phosphoglycolate phosphatase activity
I9190_RS02530	COG2378	regulation of single-species biofilm formation
I9190_RS02545	COG0583	DNA-binding transcription factor activity
I9190_RS02585	COG0753	catalase activity
I9190_RS02595	COG1960	acyl-CoA dehydrogenase activity
I9190_RS02620	COG0494	nUDIX hydrolase
I9190_RS02635	COG0583	DNA-binding transcription factor activity
I9190_RS02650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I9190_RS02665	COG0473	3-isopropylmalate dehydrogenase activity
I9190_RS02675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I9190_RS02690	COG0252	asparaginase activity
I9190_RS02725	COG1560	Kdo2-lipid A biosynthetic process
I9190_RS02765	COG0488	(ABC) transporter
I9190_RS02770	COG2900	Belongs to the SlyX family
I9190_RS02775	COG0583	DNA-binding transcription factor activity
I9190_RS02780	COG1914	H( )-stimulated, divalent metal cation uptake system
I9190_RS02800	COG4770	biotin carboxylase activity
I9190_RS02810	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS02815	COG1733	regulation of RNA biosynthetic process
I9190_RS02845	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_RS02850	COG1929	Belongs to the glycerate kinase type-1 family
I9190_RS02875	COG4651	solute:proton antiporter activity
I9190_RS02875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I9190_RS02900	COG0788	formyltetrahydrofolate deformylase activity
I9190_RS02945	COG1607	acyl-coa hydrolase
I9190_RS02960	COG1666	GTP binding
I9190_RS02965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I9190_RS02980	COG2350	Protein conserved in bacteria
I9190_RS02990	COG0613	PHP domain protein
I9190_RS03000	COG1702	phosphate starvation-inducible protein PhoH
I9190_RS03005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I9190_RS03010	COG0739	heme binding
I9190_RS03010	COG0741	lytic transglycosylase activity
I9190_RS03010	COG1196	nuclear chromosome segregation
I9190_RS03020	COG0039	L-malate dehydrogenase activity
I9190_RS03040	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I9190_RS03045	COG1183	phosphatidylcholine synthase activity
I9190_RS03085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9190_RS03090	COG1960	acyl-CoA dehydrogenase activity
I9190_RS03095	COG1960	acyl-CoA dehydrogenase activity
I9190_RS03115	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS03120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I9190_RS03125	COG1960	acyl-CoA dehydrogenase activity
I9190_RS03130	COG1024	Enoyl-CoA hydratase
I9190_RS03135	COG4770	biotin carboxylase activity
I9190_RS03140	COG0564	pseudouridine synthase activity
I9190_RS03145	COG0477	Major facilitator Superfamily
I9190_RS03150	COG1272	protein, Hemolysin III
I9190_RS03170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9190_RS03175	COG1011	Hydrolase
I9190_RS03270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9190_RS03295	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I9190_RS03300	COG3545	Serine hydrolase
I9190_RS03320	COG0730	response to heat
I9190_RS03330	COG1196	nuclear chromosome segregation
I9190_RS03340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I9190_RS03355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I9190_RS03365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9190_RS03375	COG2267	carboxylic ester hydrolase activity
I9190_RS03390	COG4106	trans-aconitate 2-methyltransferase activity
I9190_RS03405	COG3422	double-strand break repair
I9190_RS03420	COG1051	belongs to the nudix hydrolase family
I9190_RS03435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I9190_RS03440	COG2207	Transcriptional regulator
I9190_RS03445	COG0454	-acetyltransferase
I9190_RS03450	COG0456	acetyltransferase
I9190_RS03460	COG0183	Belongs to the thiolase family
I9190_RS03500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I9190_RS03505	COG0285	dihydrofolate synthase activity
I9190_RS03525	COG3713	MltA-interacting MipA family protein
I9190_RS03530	COG0009	L-threonylcarbamoyladenylate synthase
I9190_RS03535	COG3101	peptidyl-lysine hydroxylation
I9190_RS03540	COG1399	metal-binding, possibly nucleic acid-binding protein
I9190_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS03560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9190_RS03565	COG1652	LysM domain
I9190_RS03570	COG0450	alkyl hydroperoxide reductase
I9190_RS03585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I9190_RS03590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I9190_RS03620	COG2199	diguanylate cyclase activity
I9190_RS03680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I9190_RS03685	COG3878	Protein conserved in bacteria
I9190_RS03720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9190_RS03735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I9190_RS03760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_RS03760	COG2813	Specifically methylates the guanine in position
I9190_RS03770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I9190_RS03780	COG3128	pkhd-type hydroxylase
I9190_RS03785	COG4774	siderophore transport
I9190_RS03790	COG4774	siderophore transport
I9190_RS03800	COG0740	serine-type endopeptidase activity
I9190_RS03845	COG0280	phosphate acetyltransferase
I9190_RS03845	COG0857	belongs to the CobB CobQ family
I9190_RS03850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I9190_RS03895	COG2832	Protein of unknown function (DUF454)
I9190_RS03950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I9190_RS03960	COG1289	transmembrane transporter activity
I9190_RS03965	COG2814	Major facilitator Superfamily
I9190_RS03980	COG0668	transmembrane transport
I9190_RS03995	COG2081	HI0933 family
I9190_RS04000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I9190_RS04015	COG1309	transcriptional regulator
I9190_RS04030	COG2226	methyltransferase
I9190_RS04050	COG4716	Myosin-crossreactive antigen
I9190_RS04075	COG1126	abc transporter atp-binding protein
I9190_RS04080	COG0765	amino acid transport
I9190_RS04085	COG0765	amino acid transport
I9190_RS04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_RS04115	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I9190_RS04125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I9190_RS04180	COG0494	nUDIX hydrolase
I9190_RS04185	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9190_RS04190	COG1214	PFAM Peptidase M22, glycoprotease
I9190_RS04195	COG1968	undecaprenyl-diphosphatase activity
I9190_RS04210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I9190_RS04215	COG4269	membrane
I9190_RS04225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I9190_RS04235	COG2132	Multicopper oxidase
I9190_RS04260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I9190_RS04265	COG1280	lysine exporter protein (LysE YggA)
I9190_RS04280	COG0351	phosphomethylpyrimidine kinase
I9190_RS04280	COG0352	thiamine-phosphate diphosphorylase activity
I9190_RS04280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I9190_RS04305	COG0251	oxidation-reduction process
I9190_RS04310	COG1113	amino acid transport
I9190_RS04345	COG1981	membrane
I9190_RS04355	COG3831	ATPase activity
I9190_RS04365	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I9190_RS04375	COG0714	Associated with various cellular activities
I9190_RS04385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I9190_RS04410	COG0456	acetyltransferase
I9190_RS04420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I9190_RS04425	COG0500	methyltransferase
I9190_RS04430	COG0492	ferredoxin-NADP+ reductase activity
I9190_RS04435	COG1674	ftsk spoiiie
I9190_RS04435	COG0531	amino acid
I9190_RS04445	COG1280	lysine exporter protein (LysE YggA)
I9190_RS04475	COG0523	cobalamin synthesis protein
I9190_RS04480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9190_RS04535	COG0183	Belongs to the thiolase family
I9190_RS04560	COG1690	Belongs to the RtcB family
I9190_RS04565	COG0833	amino acid
I9190_RS04575	COG2233	PERMEase
I9190_RS04580	COG1217	gtp-binding protein TYPA
I9190_RS04585	COG1970	mechanosensitive ion channel activity
I9190_RS04600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9190_RS04610	COG3659	wide pore channel activity
I9190_RS04615	COG4772	TonB-dependent receptor
I9190_RS04620	COG1902	pentaerythritol trinitrate reductase activity
I9190_RS04670	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I9190_RS04690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I9190_RS04730	COG3447	MASE1 domain protein
I9190_RS04730	COG5001	Diguanylate cyclase
I9190_RS04730	COG5002	protein histidine kinase activity
I9190_RS04755	COG2969	positive regulation of protein catabolic process
I9190_RS04760	COG0625	glutathione transferase activity
I9190_RS04770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I9190_RS04775	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I9190_RS04790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I9190_RS04795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I9190_RS04835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I9190_RS04845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9190_RS04850	COG1408	metallophosphoesterase
I9190_RS04880	COG2824	Alkylphosphonate utilization operon protein PhnA
I9190_RS04885	COG0590	tRNA wobble adenosine to inosine editing
I9190_RS04915	COG4166	transmembrane transport
I9190_RS04920	COG4166	transmembrane transport
I9190_RS04935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I9190_RS04950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I9190_RS04955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I9190_RS04975	COG1309	transcriptional regulator
I9190_RS04980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_RS04990	COG2268	Band 7 protein
I9190_RS04995	COG1585	Membrane protein implicated in regulation of membrane protease activity
I9190_RS05010	COG3706	GGDEF domain
I9190_RS05015	COG0477	Major facilitator Superfamily
I9190_RS05020	COG0242	peptide deformylase activity
I9190_RS05025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I9190_RS05035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_RS05045	COG2271	Major facilitator Superfamily
I9190_RS05065	COG0477	Major facilitator Superfamily
I9190_RS05070	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS05070	COG2030	dehydratase
I9190_RS05075	COG3396	Phenylacetate-CoA oxygenase
I9190_RS05080	COG3460	Phenylacetate-CoA oxygenase
I9190_RS05085	COG3396	Phenylacetate-CoA oxygenase
I9190_RS05090	COG2151	metal-sulfur cluster biosynthetic enzyme
I9190_RS05095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9190_RS05100	COG1024	Enoyl-CoA hydratase
I9190_RS05105	COG1024	Enoyl-CoA hydratase
I9190_RS05110	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_RS05115	COG0183	Belongs to the thiolase family
I9190_RS05120	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I9190_RS05125	COG3327	negative regulation of DNA-templated transcription, initiation
I9190_RS05145	COG2985	domain, Protein
I9190_RS05160	COG1414	Transcriptional regulator
I9190_RS05165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_RS05210	COG1733	regulation of RNA biosynthetic process
I9190_RS05230	COG2771	luxR family
I9190_RS05235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS05250	COG0789	Transcriptional regulator
I9190_RS05265	COG1132	(ABC) transporter
I9190_RS05265	COG2375	cellular response to nickel ion
I9190_RS05275	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I9190_RS05280	COG4605	iron ion homeostasis
I9190_RS05285	COG4604	ABC transporter, ATP-binding protein
I9190_RS05290	COG4607	ABC-type enterochelin transport system periplasmic component
I9190_RS05295	COG4774	siderophore transport
I9190_RS05315	COG2267	carboxylic ester hydrolase activity
I9190_RS05320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS05325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_RS05330	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS05335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I9190_RS05345	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS05350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_RS05370	COG3706	GGDEF domain
I9190_RS05375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_RS05380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I9190_RS05390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9190_RS05395	COG0505	Belongs to the CarA family
I9190_RS05410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I9190_RS05430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS05435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS05440	COG0745	RESPONSE REGULATOR receiver
I9190_RS05450	COG5002	protein histidine kinase activity
I9190_RS05460	COG3135	benzoate transporter
I9190_RS05465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_RS05475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9190_RS05480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I9190_RS05485	COG0022	dehydrogenase e1 component
I9190_RS05490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I9190_RS05495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_RS05505	COG1063	alcohol dehydrogenase
I9190_RS05525	COG0583	DNA-binding transcription factor activity
I9190_RS05530	COG0473	3-isopropylmalate dehydrogenase activity
I9190_RS05540	COG0657	acetylesterase activity
I9190_RS05545	COG4638	Rieske (2fe-2S)
I9190_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS05570	COG3539	Fimbrial protein
I9190_RS05585	COG3121	Chaperone
I9190_RS05595	COG3539	Fimbrial protein
I9190_RS05615	COG3539	Fimbrial protein
I9190_RS05635	COG3121	Chaperone
I9190_RS05645	COG3539	Fimbrial protein
I9190_RS05660	COG0523	cobalamin synthesis protein
I9190_RS05670	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_RS05670	COG1902	pentaerythritol trinitrate reductase activity
I9190_RS05680	COG0789	Transcriptional regulator
I9190_RS05695	COG2871	sodium ion transport
I9190_RS05730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_RS05735	COG0183	Belongs to the thiolase family
I9190_RS05740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_RS05745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9190_RS05755	COG4829	muconolactone delta-isomerase
I9190_RS05760	COG4948	Mandelate Racemase Muconate Lactonizing
I9190_RS05765	COG0583	DNA-binding transcription factor activity
I9190_RS05795	COG0583	DNA-binding transcription factor activity
I9190_RS05800	COG3590	peptidase
I9190_RS05815	COG2318	DinB family
I9190_RS05835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9190_RS05845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I9190_RS05850	COG1077	Cell shape determining protein MreB Mrl
I9190_RS05855	COG1792	Involved in formation and maintenance of cell shape
I9190_RS05860	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I9190_RS05865	COG0424	maF-like protein
I9190_RS05880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I9190_RS05895	COG0560	Phosphoserine phosphatase
I9190_RS05920	COG4181	ATPase activity
I9190_RS05925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I9190_RS05935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9190_RS05950	COG0583	DNA-binding transcription factor activity
I9190_RS05960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_RS05965	COG1773	rubredoxin
I9190_RS05970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I9190_RS06000	COG2354	Protein conserved in bacteria
I9190_RS06005	COG2321	neutral zinc metallopeptidase
I9190_RS06030	COG1024	Enoyl-CoA hydratase
I9190_RS06050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_RS06065	COG0625	glutathione transferase activity
I9190_RS06075	COG1113	amino acid transport
I9190_RS06085	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I9190_RS06095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I9190_RS06100	COG0505	Belongs to the CarA family
I9190_RS06120	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
I9190_RS06125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9190_RS06130	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I9190_RS06150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9190_RS06150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I9190_RS06175	COG0300	oxidoreductase activity
I9190_RS06180	COG2072	flavoprotein involved in K transport
I9190_RS06215	COG2009	succinate dehydrogenase
I9190_RS06220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I9190_RS06225	COG1053	succinate dehydrogenase
I9190_RS06230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I9190_RS06245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_RS06255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I9190_RS06260	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS06280	COG0742	ribosomal rna small subunit methyltransferase
I9190_RS06285	COG0768	penicillin binding
I9190_RS06315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I9190_RS06320	COG2878	Part of a membrane complex involved in electron transport
I9190_RS06325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_RS06340	COG3384	dioxygenase
I9190_RS06350	COG2234	aminopeptidase activity
I9190_RS06395	COG1280	lysine exporter protein (LysE YggA)
I9190_RS06440	COG3323	Protein of unknown function (DUF1653)
I9190_RS06440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9190_RS06445	COG0778	Nitroreductase
I9190_RS06450	COG1024	Enoyl-CoA hydratase
I9190_RS06455	COG1051	belongs to the nudix hydrolase family
I9190_RS06455	COG1056	cytidyltransferase-related domain
I9190_RS06470	COG0625	glutathione transferase activity
I9190_RS06480	COG0583	DNA-binding transcription factor activity
I9190_RS06490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I9190_RS06505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I9190_RS06510	COG0602	queuosine metabolic process
I9190_RS06530	COG0583	DNA-binding transcription factor activity
I9190_RS06535	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I9190_RS06540	COG4208	sulfate ABC transporter
I9190_RS06545	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I9190_RS06555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I9190_RS06560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I9190_RS06565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I9190_RS06605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9190_RS06615	COG0671	phosphoesterase, PA-phosphatase related
I9190_RS06620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I9190_RS06625	COG0463	Glycosyl transferase, family 2
I9190_RS06650	COG0571	ribonuclease III activity
I9190_RS06655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I9190_RS06670	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I9190_RS06680	COG0667	Aldo Keto reductase
I9190_RS06690	COG0251	oxidation-reduction process
I9190_RS06695	COG0583	DNA-binding transcription factor activity
I9190_RS06710	COG0415	Belongs to the DNA photolyase family
I9190_RS06715	COG1047	Peptidyl-prolyl cis-trans
I9190_RS06720	COG1252	NADH dehydrogenase
I9190_RS06725	COG1686	Belongs to the peptidase S11 family
I9190_RS06735	COG2351	hydroxyisourate hydrolase activity
I9190_RS06750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I9190_RS06755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_RS06760	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I9190_RS06795	COG0281	malic enzyme
I9190_RS06795	COG0280	phosphate acetyltransferase
I9190_RS06805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9190_RS06810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I9190_RS06815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I9190_RS06835	COG0154	amidase activity
I9190_RS06870	COG1960	acyl-CoA dehydrogenase activity
I9190_RS06920	COG0583	DNA-binding transcription factor activity
I9190_RS06925	COG0697	spore germination
I9190_RS06935	COG2186	Transcriptional regulator
I9190_RS06945	COG0277	FAD linked oxidase domain protein
I9190_RS06955	COG1902	pentaerythritol trinitrate reductase activity
I9190_RS06955	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_RS06965	COG0582	viral genome integration into host DNA
I9190_RS06985	COG2831	hemolysin activation secretion protein
I9190_RS07025	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS07050	COG2072	flavoprotein involved in K transport
I9190_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS07145	COG0531	amino acid
I9190_RS07150	COG2957	Belongs to the agmatine deiminase family
I9190_RS07155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_RS07155	COG1116	anion transmembrane transporter activity
I9190_RS07165	COG2223	nitrite transmembrane transporter activity
I9190_RS07170	COG2146	nitrite reductase [NAD(P)H] activity
I9190_RS07170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_RS07175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_RS07180	COG0243	molybdopterin cofactor binding
I9190_RS07190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I9190_RS07200	COG0314	molybdopterin synthase activity
I9190_RS07205	COG0315	cyclic pyranopterin monophosphate synthase activity
I9190_RS07205	COG0521	Mo-molybdopterin cofactor biosynthetic process
I9190_RS07210	COG0303	'Molybdopterin
I9190_RS07215	COG0725	ABC transporter, periplasmic molybdate-binding protein
I9190_RS07220	COG4149	molybdate abc transporter
I9190_RS07225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I9190_RS07230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_RS07240	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I9190_RS07245	COG0583	DNA-binding transcription factor activity
I9190_RS07265	COG0439	Biotin carboxylase
I9190_RS07270	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_RS07275	COG1733	regulation of RNA biosynthetic process
I9190_RS07280	COG0864	Transcriptional regulator
I9190_RS07310	COG1116	anion transmembrane transporter activity
I9190_RS07330	COG0596	Alpha beta hydrolase
I9190_RS07340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_RS07345	COG1335	isochorismatase
I9190_RS07350	COG0251	oxidation-reduction process
I9190_RS07355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS07360	COG2233	PERMEase
I9190_RS07375	COG0235	Class ii aldolase
I9190_RS07380	COG1741	Belongs to the pirin family
I9190_RS07395	COG3739	integral membrane protein
I9190_RS07415	COG0531	amino acid
I9190_RS07420	COG4303	Ethanolamine ammonia lyase large subunit
I9190_RS07425	COG4302	ethanolamine ammonia-lyase activity
I9190_RS07430	COG1960	acyl-CoA dehydrogenase activity
I9190_RS07435	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS07465	COG0302	gtp cyclohydrolase
I9190_RS07485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9190_RS07490	COG0512	Glutamine amidotransferase of anthranilate synthase
I9190_RS07545	COG0174	glutamine synthetase
I9190_RS07565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I9190_RS07590	COG0823	Involved in the tonB-independent uptake of proteins
I9190_RS07620	COG0824	Thioesterase
I9190_RS07650	COG4771	TonB-dependent receptor
I9190_RS07685	COG0047	phosphoribosylformylglycinamidine synthase activity
I9190_RS07685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I9190_RS07700	COG1301	dicarboxylic acid transport
I9190_RS07715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS07740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I9190_RS07790	COG1960	acyl-CoA dehydrogenase activity
I9190_RS07795	COG0183	Belongs to the thiolase family
I9190_RS07800	COG0427	acetyl-CoA hydrolase
I9190_RS07810	COG0517	IMP dehydrogenase activity
I9190_RS07810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9190_RS07815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I9190_RS07825	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I9190_RS07830	COG1137	ATPase activity
I9190_RS07855	COG4122	O-methyltransferase activity
I9190_RS07870	COG0573	inorganic phosphate transmembrane transporter activity
I9190_RS07880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I9190_RS07885	COG1301	dicarboxylic acid transport
I9190_RS07890	COG0616	signal peptide processing
I9190_RS07895	COG1960	acyl-CoA dehydrogenase activity
I9190_RS07905	COG0693	protein deglycase activity
I9190_RS07915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I9190_RS07935	COG0430	RNA-3'-phosphate cyclase activity
I9190_RS07960	COG1690	Belongs to the RtcB family
I9190_RS07975	COG1234	tRNA 3'-trailer cleavage
I9190_RS07980	COG4650	regulator
I9190_RS07990	COG3022	response to hydroperoxide
I9190_RS08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9190_RS08095	COG2011	ABC-type metal ion transport system permease component
I9190_RS08100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9190_RS08105	COG1464	Belongs to the NlpA lipoprotein family
I9190_RS08115	COG0151	Belongs to the GarS family
I9190_RS08120	COG0138	bifunctional purine biosynthesis protein purh
I9190_RS08125	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I9190_RS08165	COG2308	Evidence 4 Homologs of previously reported genes of
I9190_RS08175	COG1305	Transglutaminase-like
I9190_RS08195	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I9190_RS08205	COG0305	Participates in initiation and elongation during chromosome replication
I9190_RS08215	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I9190_RS08220	COG0360	Binds together with S18 to 16S ribosomal RNA
I9190_RS08240	COG0109	protoheme IX farnesyltransferase activity
I9190_RS08245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I9190_RS08250	COG1845	cytochrome c oxidase, subunit III
I9190_RS08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I9190_RS08260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I9190_RS08290	COG4682	membrane
I9190_RS08295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_RS08315	COG2890	protein-(glutamine-N5) methyltransferase activity
I9190_RS08320	COG3781	membrane
I9190_RS08325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_RS08330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_RS08350	COG1960	acyl-CoA dehydrogenase activity
I9190_RS08355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_RS08365	COG4585	Histidine kinase
I9190_RS08375	COG0659	secondary active sulfate transmembrane transporter activity
I9190_RS08385	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_RS08390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I9190_RS08420	COG2363	Small membrane protein
I9190_RS08440	COG0513	Belongs to the DEAD box helicase family
I9190_RS08450	COG0778	Nitroreductase
I9190_RS08475	COG0167	dihydroorotate dehydrogenase activity
I9190_RS08505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I9190_RS08505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I9190_RS08510	COG1254	Belongs to the acylphosphatase family
I9190_RS08540	COG1280	lysine exporter protein (LysE YggA)
I9190_RS08575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I9190_RS08590	COG2353	YceI-like domain
I9190_RS08600	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_RS08610	COG3042	response to heat
I9190_RS08615	COG0519	Catalyzes the synthesis of GMP from XMP
I9190_RS08615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9190_RS08620	COG1309	transcriptional regulator
I9190_RS08640	COG0583	DNA-binding transcription factor activity
I9190_RS08660	COG3284	Transcriptional regulator
I9190_RS08675	COG1454	alcohol dehydrogenase
I9190_RS08685	COG0183	Belongs to the thiolase family
I9190_RS08730	COG0824	Thioesterase
I9190_RS08740	COG1454	alcohol dehydrogenase
I9190_RS08805	COG0537	adenosine 5'-monophosphoramidase activity
I9190_RS08835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I9190_RS08855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I9190_RS08865	COG0133	tryptophan synthase activity
I9190_RS08875	COG0517	IMP dehydrogenase activity
I9190_RS08875	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I9190_RS08905	COG0612	Peptidase, M16
I9190_RS08910	COG0552	protein localization to endoplasmic reticulum
I9190_RS08920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I9190_RS08940	COG1253	flavin adenine dinucleotide binding
I9190_RS08960	COG1114	Component of the transport system for branched-chain amino acids
I9190_RS08965	COG0024	Methionine aminopeptidase
I9190_RS08970	COG3135	benzoate transporter
I9190_RS08980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I9190_RS09000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_RS09005	COG2119	membrane
I9190_RS09010	COG2194	sulfuric ester hydrolase activity
I9190_RS09065	COG4890	Cyd operon protein YbgT
I9190_RS09070	COG1294	oxidase, subunit
I9190_RS09085	COG2249	NAD(P)H dehydrogenase (quinone) activity
I9190_RS09100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I9190_RS09105	COG2153	protein acetylation
I9190_RS09120	COG1846	Transcriptional regulator
I9190_RS09125	COG1132	(ABC) transporter
I9190_RS09130	COG1304	FMN binding
I9190_RS09145	COG4773	Receptor
I9190_RS09150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_RS09165	COG3753	Protein conserved in bacteria
I9190_RS09180	COG3852	Histidine kinase
I9190_RS09195	COG0233	cytoplasmic translational termination
I9190_RS09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I9190_RS09205	COG0575	Belongs to the CDS family
I9190_RS09220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9190_RS09230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_RS09240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I9190_RS09260	COG2137	regulation of response to DNA damage stimulus
I9190_RS09265	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_RS09270	COG4221	oxidoreductase activity
I9190_RS09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I9190_RS09280	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I9190_RS09285	COG1011	Hydrolase
I9190_RS09315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9190_RS09320	COG0730	response to heat
I9190_RS09340	COG0439	Biotin carboxylase
I9190_RS09345	COG0511	ligase activity, forming carbon-carbon bonds
I9190_RS09385	COG1846	Transcriptional regulator
I9190_RS09395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I9190_RS09410	COG0308	aminopeptidase N
I9190_RS09445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I9190_RS09445	COG0506	proline dehydrogenase activity
I9190_RS09445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I9190_RS09455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_RS09470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I9190_RS09490	COG0477	Major facilitator Superfamily
I9190_RS09500	COG3179	chitinase
I9190_RS09520	COG3135	benzoate transporter
I9190_RS09525	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS09530	COG0543	2 iron, 2 sulfur cluster binding
I9190_RS09530	COG0633	Ferredoxin
I9190_RS09535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I9190_RS09540	COG4638	Rieske (2fe-2S)
I9190_RS09550	COG0583	DNA-binding transcription factor activity
I9190_RS09555	COG2814	Major facilitator Superfamily
I9190_RS09575	COG1902	pentaerythritol trinitrate reductase activity
I9190_RS09575	COG0446	pyridine nucleotide-disulphide oxidoreductase
I9190_RS09600	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I9190_RS09610	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I9190_RS09620	COG0772	Belongs to the SEDS family
I9190_RS09625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_RS09675	COG0583	DNA-binding transcription factor activity
I9190_RS09680	COG0667	Aldo Keto reductase
I9190_RS09710	COG1309	transcriptional regulator
I9190_RS09715	COG0596	Alpha beta hydrolase
I9190_RS09715	COG2226	methyltransferase
I9190_RS09715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I9190_RS09720	COG2937	Belongs to the GPAT DAPAT family
I9190_RS09725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I9190_RS09785	COG4589	Belongs to the CDS family
I9190_RS09800	COG2453	phosphatase
I9190_RS09800	COG0671	phosphoesterase, PA-phosphatase related
I9190_RS09805	COG2267	carboxylic ester hydrolase activity
I9190_RS09810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I9190_RS09860	COG2223	nitrite transmembrane transporter activity
I9190_RS09880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I9190_RS09895	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I9190_RS09915	COG0640	Transcriptional regulator
I9190_RS09925	COG3122	Protein conserved in bacteria
I9190_RS09930	COG3619	membrane
I9190_RS09945	COG0640	Transcriptional regulator
I9190_RS09975	COG3300	MHYT domain
I9190_RS09975	COG5001	Diguanylate cyclase
I9190_RS09980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I9190_RS09985	COG0509	glycine decarboxylation via glycine cleavage system
I9190_RS10005	COG1960	acyl-CoA dehydrogenase activity
I9190_RS10010	COG1960	acyl-CoA dehydrogenase activity
I9190_RS10060	COG0589	response to stress
I9190_RS10070	COG0830	nickel cation binding
I9190_RS10085	COG0829	nickel cation binding
I9190_RS10105	COG0804	urea catabolic process
I9190_RS10140	COG2351	hydroxyisourate hydrolase activity
I9190_RS10150	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I9190_RS10155	COG4266	Belongs to the allantoicase family
I9190_RS10160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_RS10165	COG0583	DNA-binding transcription factor activity
I9190_RS10180	COG1944	ATP diphosphatase activity
I9190_RS10200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_RS10205	COG1960	acyl-CoA dehydrogenase activity
I9190_RS10210	COG1024	Enoyl-CoA hydratase
I9190_RS10220	COG0477	Major facilitator Superfamily
I9190_RS10235	COG1881	PFAM PEBP family protein
I9190_RS10240	COG2207	Transcriptional regulator
I9190_RS10250	COG4774	siderophore transport
I9190_RS10260	COG2814	Major facilitator Superfamily
I9190_RS10390	COG0583	DNA-binding transcription factor activity
I9190_RS10395	COG1380	Effector of murein hydrolase LrgA
I9190_RS10400	COG1346	cytolysis
I9190_RS10405	COG2814	Major facilitator Superfamily
I9190_RS10420	COG0697	spore germination
I9190_RS10425	COG0596	Alpha beta hydrolase
I9190_RS10430	COG1448	Aminotransferase
I9190_RS10435	COG0488	(ABC) transporter
I9190_RS10470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9190_RS10475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I9190_RS10485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_RS10490	COG0697	spore germination
I9190_RS10545	COG0583	DNA-binding transcription factor activity
I9190_RS10550	COG3152	Membrane
I9190_RS10560	COG1294	oxidase, subunit
I9190_RS10565	COG1271	oxidase subunit
I9190_RS10575	COG2207	Transcriptional regulator
I9190_RS10580	COG1960	acyl-CoA dehydrogenase activity
I9190_RS10600	COG1733	regulation of RNA biosynthetic process
I9190_RS10630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9190_RS10640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9190_RS10775	COG4387	Mu-like prophage protein GP36
I9190_RS10920	COG2199	diguanylate cyclase activity
I9190_RS10920	COG2203	Gaf domain
I9190_RS10970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I9190_RS11000	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS11005	COG2207	Transcriptional regulator
I9190_RS11015	COG0776	regulation of translation
I9190_RS11030	COG1959	2 iron, 2 sulfur cluster binding
I9190_RS11040	COG0822	iron-sulfur transferase activity
I9190_RS11045	COG0316	Belongs to the HesB IscA family
I9190_RS11075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I9190_RS11105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I9190_RS11110	COG0702	epimerase
I9190_RS11120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I9190_RS11145	COG3196	Protein conserved in bacteria
I9190_RS11170	COG0126	phosphoglycerate kinase activity
I9190_RS11180	COG0424	maF-like protein
I9190_RS11185	COG2850	peptidyl-arginine hydroxylation
I9190_RS11195	COG0069	glutamate synthase activity
I9190_RS11215	COG3433	isochorismatase activity
I9190_RS11215	COG1535	isochorismatase
I9190_RS11220	COG0372	Belongs to the citrate synthase family
I9190_RS11260	COG2814	Major facilitator Superfamily
I9190_RS11265	COG1960	acyl-CoA dehydrogenase activity
I9190_RS11270	COG0583	DNA-binding transcription factor activity
I9190_RS11280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_RS11285	COG0583	DNA-binding transcription factor activity
I9190_RS11310	COG0657	acetylesterase activity
I9190_RS11310	COG2755	lipolytic protein G-D-S-L family
I9190_RS11315	COG0542	response to heat
I9190_RS11320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I9190_RS11335	COG3706	GGDEF domain
I9190_RS11370	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I9190_RS11375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I9190_RS11390	COG0569	domain protein
I9190_RS11395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I9190_RS11400	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I9190_RS11415	COG2431	L-lysine efflux transmembrane transporter activity
I9190_RS11420	COG0284	orotidine-5'-phosphate decarboxylase activity
I9190_RS11455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I9190_RS11465	COG0590	tRNA wobble adenosine to inosine editing
I9190_RS11475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I9190_RS11485	COG3156	type II secretion system protein K
I9190_RS11510	COG0084	hydrolase, TatD family'
I9190_RS11530	COG1663	tetraacyldisaccharide 4'-kinase activity
I9190_RS11535	COG1132	(ABC) transporter
I9190_RS11545	COG0811	peptide transport
I9190_RS11550	COG1475	DNA binding
I9190_RS11555	COG1192	Involved in chromosome partitioning
I9190_RS11565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I9190_RS11570	COG3178	'Phosphotransferase
I9190_RS11580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I9190_RS11615	COG1923	regulation of RNA biosynthetic process
I9190_RS11625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I9190_RS11630	COG0802	atpase or kinase
I9190_RS11650	COG1187	pseudouridine synthase activity
I9190_RS11655	COG0492	ferredoxin-NADP+ reductase activity
I9190_RS11660	COG1959	2 iron, 2 sulfur cluster binding
I9190_RS11665	COG2707	UPF0756 membrane protein
I9190_RS11690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9190_RS11800	COG4397	Mu-like prophage major head subunit gpT
I9190_RS11815	COG5005	Phage virion morphogenesis
I9190_RS11825	COG4383	Mu-like prophage protein gp29
I9190_RS11840	COG4373	Mu-like prophage FluMu protein gp28
I9190_RS11875	COG0681	Belongs to the peptidase S26 family
I9190_RS11955	COG4382	Mu-like prophage protein Gp16
I9190_RS12020	COG1464	Belongs to the NlpA lipoprotein family
I9190_RS12025	COG1464	Belongs to the NlpA lipoprotein family
I9190_RS12030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I9190_RS12035	COG2011	ABC-type metal ion transport system permease component
I9190_RS12040	COG0012	GTP binding
I9190_RS12065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_RS12090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I9190_RS12110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I9190_RS12160	COG2207	Transcriptional regulator
I9190_RS12160	COG1917	Cupin 2, conserved barrel domain protein
I9190_RS12165	COG0386	Belongs to the glutathione peroxidase family
I9190_RS12170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_RS12175	COG0436	Aminotransferase
I9190_RS12205	COG1610	YqeY-like protein
I9190_RS12215	COG4783	chaperone-mediated protein folding
I9190_RS12235	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_RS12255	COG0729	surface antigen
I9190_RS12260	COG0477	Major facilitator Superfamily
I9190_RS12280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I9190_RS12290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I9190_RS12305	COG0204	Acyl-transferase
I9190_RS12320	COG1309	transcriptional regulator
I9190_RS12370	COG3340	Belongs to the peptidase S51 family
I9190_RS12390	COG0583	DNA-binding transcription factor activity
I9190_RS12395	COG3040	lipid binding
I9190_RS12400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I9190_RS12410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I9190_RS12435	COG0540	Belongs to the ATCase OTCase family
I9190_RS12510	COG0542	response to heat
I9190_RS12520	COG1045	serine acetyltransferase
I9190_RS12530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I9190_RS12535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I9190_RS12545	COG1765	OsmC-like protein
I9190_RS12555	COG0667	Aldo Keto reductase
I9190_RS12575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I9190_RS12590	COG1335	isochorismatase
I9190_RS12595	COG1522	sequence-specific DNA binding
I9190_RS12600	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I9190_RS12605	COG1522	sequence-specific DNA binding
I9190_RS12625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I9190_RS12645	COG0527	aspartate kinase activity
I9190_RS12655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I9190_RS12740	COG3038	cytochrome b561
I9190_RS12750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I9190_RS12755	COG2252	PERMEase
I9190_RS12770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS12805	COG4771	TonB-dependent receptor
I9190_RS12825	COG0714	Associated with various cellular activities
I9190_RS12835	COG2879	small protein
I9190_RS12840	COG1966	Carbon starvation protein
I9190_RS12845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I9190_RS12850	COG1509	lysine 2,3-aminomutase activity
I9190_RS12885	COG1067	ATP-dependent peptidase activity
I9190_RS12890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9190_RS12895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I9190_RS12905	COG4942	peptidase
I9190_RS12910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I9190_RS12925	COG1686	Belongs to the peptidase S11 family
I9190_RS12930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I9190_RS12965	COG2915	High frequency lysogenization protein hflD homolog
I9190_RS12980	COG1733	regulation of RNA biosynthetic process
I9190_RS12985	COG0702	epimerase
I9190_RS13020	COG2962	Rard protein
I9190_RS13030	COG0556	nucleotide-excision repair
I9190_RS13040	COG3300	MHYT domain
I9190_RS13040	COG5001	Diguanylate cyclase
I9190_RS13055	COG0436	Aminotransferase
I9190_RS13075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS13085	COG2223	nitrite transmembrane transporter activity
I9190_RS13095	COG0477	Major facilitator Superfamily
I9190_RS13130	COG0028	Belongs to the TPP enzyme family
I9190_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS13150	COG2267	carboxylic ester hydrolase activity
I9190_RS13160	COG2271	Major facilitator Superfamily
I9190_RS13235	COG0583	DNA-binding transcription factor activity
I9190_RS13280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS13290	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS13315	COG0154	amidase activity
I9190_RS13325	COG1250	3-hydroxyacyl-CoA dehydrogenase
I9190_RS13335	COG2207	Transcriptional regulator
I9190_RS13335	COG3708	Transcriptional regulator
I9190_RS13340	COG2814	Major facilitator Superfamily
I9190_RS13350	COG2610	gluconate transmembrane transporter activity
I9190_RS13355	COG1454	alcohol dehydrogenase
I9190_RS13380	COG2271	Major facilitator Superfamily
I9190_RS13385	COG0697	spore germination
I9190_RS13395	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS13400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I9190_RS13405	COG2271	Major facilitator Superfamily
I9190_RS13415	COG2186	Transcriptional regulator
I9190_RS13420	COG1785	Belongs to the alkaline phosphatase family
I9190_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS13440	COG3321	synthase
I9190_RS13440	COG0604	alcohol dehydrogenase
I9190_RS13445	COG1309	transcriptional regulator
I9190_RS13450	COG0477	Major facilitator Superfamily
I9190_RS13465	COG2814	Major facilitator Superfamily
I9190_RS13470	COG1309	transcriptional regulator
I9190_RS13480	COG5487	UPF0391 membrane protein
I9190_RS13500	COG0693	protein deglycase activity
I9190_RS13530	COG3008	intermembrane lipid transfer
I9190_RS13530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9190_RS13535	COG2995	paraquat-inducible protein a
I9190_RS13560	COG0745	RESPONSE REGULATOR receiver
I9190_RS13565	COG0642	Histidine kinase
I9190_RS13580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I9190_RS13615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I9190_RS13625	COG0076	glutamate decarboxylase activity
I9190_RS13630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I9190_RS13640	COG4772	TonB-dependent receptor
I9190_RS13670	COG1309	transcriptional regulator
I9190_RS13685	COG1022	Amp-dependent synthetase and ligase
I9190_RS13730	COG0789	Transcriptional regulator
I9190_RS13735	COG0798	PFAM Bile acid sodium symporter
I9190_RS13740	COG0640	Transcriptional regulator
I9190_RS13750	COG0826	peptidase U32
I9190_RS13755	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9190_RS13760	COG0583	DNA-binding transcription factor activity
I9190_RS13765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I9190_RS13770	COG3634	alkyl hydroperoxide reductase activity
I9190_RS13810	COG0628	permease
I9190_RS13820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I9190_RS13840	COG0658	competence protein
I9190_RS13840	COG2333	competence protein COMEC
I9190_RS13845	COG1136	(ABC) transporter
I9190_RS13870	COG2072	flavoprotein involved in K transport
I9190_RS13890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_RS13895	COG0010	Belongs to the arginase family
I9190_RS13905	COG1113	amino acid transport
I9190_RS13925	COG2188	Transcriptional regulator
I9190_RS13930	COG2831	hemolysin activation secretion protein
I9190_RS13935	COG3210	domain, Protein
I9190_RS13970	COG1643	Atp-dependent helicase
I9190_RS13995	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I9190_RS14020	COG2070	2-Nitropropane dioxygenase
I9190_RS14025	COG2318	DinB family
I9190_RS14065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I9190_RS14075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I9190_RS14080	COG1301	dicarboxylic acid transport
I9190_RS14085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I9190_RS14095	COG3139	Protein of unknown function (DUF1315)
I9190_RS14100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I9190_RS14105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I9190_RS14115	COG0494	nUDIX hydrolase
I9190_RS14125	COG0642	Histidine kinase
I9190_RS14135	COG3111	PFAM Bacterial OB fold (BOF) protein
I9190_RS14140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I9190_RS14185	COG0352	thiamine-phosphate diphosphorylase activity
I9190_RS14200	COG3025	triphosphatase activity
I9190_RS14205	COG1720	tRNA m6t6A37 methyltransferase activity
I9190_RS14220	COG0612	Peptidase, M16
I9190_RS14240	COG1823	symporter activity
I9190_RS14245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I9190_RS14255	COG2233	PERMEase
I9190_RS14265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I9190_RS14280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9190_RS14340	COG1131	(ABC) transporter
I9190_RS14345	COG0842	Transport permease protein
I9190_RS14360	COG0772	Belongs to the SEDS family
I9190_RS14365	COG2951	lytic endotransglycosylase activity
I9190_RS14415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I9190_RS14420	COG0052	Belongs to the universal ribosomal protein uS2 family
I9190_RS14425	COG0024	Methionine aminopeptidase
I9190_RS14445	COG4172	Belongs to the ABC transporter superfamily
I9190_RS14450	COG4239	(ABC) transporter, permease
I9190_RS14455	COG4174	ABC transporter (Permease)
I9190_RS14460	COG4166	transmembrane transport
I9190_RS14465	COG0741	lytic transglycosylase activity
I9190_RS14465	COG1388	LysM domain
I9190_RS14470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9190_RS14520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_RS14525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I9190_RS14530	COG0006	proline dipeptidase activity
I9190_RS14570	COG1629	transport
I9190_RS14615	COG1595	DNA-templated transcription, initiation
I9190_RS14625	COG2832	Protein of unknown function (DUF454)
I9190_RS14640	COG0745	RESPONSE REGULATOR receiver
I9190_RS14645	COG2205	protein histidine kinase activity
I9190_RS14655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I9190_RS14660	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I9190_RS14665	COG1968	undecaprenyl-diphosphatase activity
I9190_RS14670	COG1923	regulation of RNA biosynthetic process
I9190_RS14685	COG2205	protein histidine kinase activity
I9190_RS14690	COG2217	Heavy metal translocating P-type atpase
I9190_RS14710	COG0789	Transcriptional regulator
I9190_RS14725	COG0583	DNA-binding transcription factor activity
I9190_RS14735	COG0583	DNA-binding transcription factor activity
I9190_RS14750	COG3188	usher protein
I9190_RS14765	COG4993	Dehydrogenase
I9190_RS14770	COG3659	wide pore channel activity
I9190_RS14775	COG3420	alginic acid biosynthetic process
I9190_RS14780	COG0710	3-dehydroquinate dehydratase activity
I9190_RS14785	COG3485	protocatechuate 3,4-dioxygenase
I9190_RS14790	COG3485	protocatechuate 3,4-dioxygenase
I9190_RS14795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I9190_RS14800	COG2271	Major facilitator Superfamily
I9190_RS14805	COG0596	Alpha beta hydrolase
I9190_RS14810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I9190_RS14815	COG0183	Belongs to the thiolase family
I9190_RS14820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_RS14825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I9190_RS14830	COG1414	Transcriptional regulator
I9190_RS14900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_RS14920	COG3712	iron ion homeostasis
I9190_RS14925	COG1595	DNA-templated transcription, initiation
I9190_RS14940	COG0583	DNA-binding transcription factor activity
I9190_RS14960	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS14965	COG2610	gluconate transmembrane transporter activity
I9190_RS14970	COG0583	DNA-binding transcription factor activity
I9190_RS14980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I9190_RS14985	COG0625	glutathione transferase activity
I9190_RS14990	COG0668	transmembrane transport
I9190_RS14995	COG0582	viral genome integration into host DNA
I9190_RS15030	COG1230	cation diffusion facilitator family transporter
I9190_RS15045	COG2814	Major facilitator Superfamily
I9190_RS15145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I9190_RS15170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_RS15195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_RS15240	COG0582	viral genome integration into host DNA
I9190_RS15250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I9190_RS15255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I9190_RS15265	COG0037	tRNA processing
I9190_RS15270	COG0741	lytic transglycosylase activity
I9190_RS15275	COG0501	Belongs to the peptidase M48B family
I9190_RS15295	COG0418	dihydroorotase activity
I9190_RS15300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I9190_RS15310	COG0833	amino acid
I9190_RS15320	COG0833	amino acid
I9190_RS15325	COG0596	Alpha beta hydrolase
I9190_RS15340	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I9190_RS15350	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I9190_RS15370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I9190_RS15375	COG0019	diaminopimelate decarboxylase activity
I9190_RS15385	COG1113	amino acid transport
I9190_RS15405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I9190_RS15410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I9190_RS15415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I9190_RS15445	COG2239	Acts as a magnesium transporter
I9190_RS15450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS15455	COG0584	glycerophosphoryl diester phosphodiesterase
I9190_RS15465	COG0459	protein refolding
I9190_RS15475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9190_RS15480	COG1597	lipid kinase activity
I9190_RS15485	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I9190_RS15510	COG0477	Major facilitator Superfamily
I9190_RS15570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I9190_RS15575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I9190_RS15580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I9190_RS15605	COG0564	pseudouridine synthase activity
I9190_RS15615	COG0358	DNA primase activity
I9190_RS15660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9190_RS15665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I9190_RS15670	COG0193	aminoacyl-tRNA hydrolase activity
I9190_RS15690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9190_RS15705	COG0586	Pfam SNARE associated Golgi protein
I9190_RS15710	COG1280	lysine exporter protein (LysE YggA)
I9190_RS15735	COG2921	Belongs to the UPF0250 family
I9190_RS15740	COG0321	lipoyl(octanoyl) transferase activity
I9190_RS15755	COG0531	amino acid
I9190_RS15780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I9190_RS15785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I9190_RS15785	COG1648	precorrin-2 dehydrogenase activity
I9190_RS15790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I9190_RS15800	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I9190_RS15810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I9190_RS15825	COG0671	phosphoesterase, PA-phosphatase related
I9190_RS15830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS15845	COG0393	Putative heavy-metal-binding
I9190_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS15875	COG0525	valine-tRNA ligase activity
I9190_RS15880	COG2852	Protein conserved in bacteria
I9190_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS15905	COG0004	ammonium transporteR
I9190_RS15920	COG0642	Histidine kinase
I9190_RS15930	COG2194	sulfuric ester hydrolase activity
I9190_RS15945	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9190_RS15960	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_RS15965	COG0142	geranyltranstransferase activity
I9190_RS15975	COG2828	Protein conserved in bacteria
I9190_RS15980	COG1113	amino acid transport
I9190_RS16015	COG4771	TonB-dependent receptor
I9190_RS16030	COG1024	Enoyl-CoA hydratase
I9190_RS16040	COG1309	transcriptional regulator
I9190_RS16075	COG1215	transferase activity, transferring glycosyl groups
I9190_RS16080	COG1649	PFAM Uncharacterised BCR, COG1649
I9190_RS16080	COG0726	polysaccharide deacetylase
I9190_RS16100	COG4681	YaeQ
I9190_RS16105	COG0523	cobalamin synthesis protein
I9190_RS16125	COG1607	acyl-coa hydrolase
I9190_RS16130	COG1752	Esterase of the alpha-beta hydrolase superfamily
I9190_RS16135	COG2059	Chromate
I9190_RS16140	COG0786	glutamate:sodium symporter activity
I9190_RS16150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I9190_RS16185	COG0420	3'-5' exonuclease activity
I9190_RS16210	COG1968	undecaprenyl-diphosphatase activity
I9190_RS16230	COG0735	belongs to the Fur family
I9190_RS16235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I9190_RS16250	COG2703	oxygen carrier activity
I9190_RS16255	COG0121	glutamine amidotransferase
I9190_RS16270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9190_RS16275	COG0756	dUTP diphosphatase activity
I9190_RS16285	COG2885	chlorophyll binding
I9190_RS16290	COG0204	Acyl-transferase
I9190_RS16300	COG0850	regulation of cytokinetic process
I9190_RS16305	COG2894	cell division
I9190_RS16310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
I9190_RS16330	COG1253	flavin adenine dinucleotide binding
I9190_RS16335	COG2851	Citrate transporter
I9190_RS16350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I9190_RS16410	COG0306	phosphate transporter
I9190_RS16425	COG2852	Protein conserved in bacteria
I9190_RS16435	COG2814	Major facilitator Superfamily
I9190_RS16440	COG1566	PFAM secretion protein HlyD family protein
I9190_RS16445	COG2050	protein possibly involved in aromatic compounds catabolism
I9190_RS16455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_RS16465	COG0583	DNA-binding transcription factor activity
I9190_RS16480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I9190_RS16490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_RS16495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9190_RS16500	COG0713	ATP synthesis coupled electron transport
I9190_RS16510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_RS16515	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
I9190_RS16525	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I9190_RS16545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I9190_RS16555	COG2205	protein histidine kinase activity
I9190_RS16560	COG0745	RESPONSE REGULATOR receiver
I9190_RS16575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I9190_RS16580	COG0431	NADPH-dependent FMN reductase
I9190_RS16585	COG0798	PFAM Bile acid sodium symporter
I9190_RS16595	COG0640	Transcriptional regulator
I9190_RS16655	COG0037	tRNA processing
I9190_RS16665	COG0248	Ppx GppA phosphatase
I9190_RS16685	COG0776	regulation of translation
I9190_RS16690	COG0072	phenylalanine-tRNA ligase activity
I9190_RS16735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I9190_RS16755	COG1238	metal cluster binding
I9190_RS16770	COG0625	glutathione transferase activity
I9190_RS16815	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_RS16825	COG1960	acyl-CoA dehydrogenase activity
I9190_RS16830	COG1960	acyl-CoA dehydrogenase activity
I9190_RS16905	COG3306	glycosyltransferase involved in LPS biosynthesis
I9190_RS16930	COG0438	transferase activity, transferring glycosyl groups
I9190_RS16955	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I9190_RS16960	COG5002	protein histidine kinase activity
I9190_RS16965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I9190_RS16975	COG5383	Protein conserved in bacteria
I9190_RS16980	COG1012	belongs to the aldehyde dehydrogenase family
I9190_RS16985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I9190_RS16990	COG0277	FAD linked oxidase domain protein
I9190_RS16990	COG0247	lactate metabolic process
I9190_RS16995	COG0583	DNA-binding transcription factor activity
I9190_RS17000	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS17015	COG0583	DNA-binding transcription factor activity
I9190_RS17040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I9190_RS17070	COG1862	Preprotein translocase
I9190_RS17125	COG2814	Major facilitator Superfamily
I9190_RS17155	COG2814	Major facilitator Superfamily
I9190_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS17175	COG0523	cobalamin synthesis protein
I9190_RS17190	COG2188	Transcriptional regulator
I9190_RS17200	COG0738	Major facilitator superfamily
I9190_RS17210	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS17220	COG4948	Mandelate Racemase Muconate Lactonizing
I9190_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS17235	COG2186	Transcriptional regulator
I9190_RS17245	COG3958	Transketolase
I9190_RS17250	COG3959	Transketolase, thiamine diphosphate binding domain
I9190_RS17255	COG2271	Major facilitator Superfamily
I9190_RS17260	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS17265	COG0583	DNA-binding transcription factor activity
I9190_RS17285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_RS17290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I9190_RS17295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_RS17310	COG0183	Belongs to the thiolase family
I9190_RS17315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_RS17345	COG1484	DNA-dependent DNA replication
I9190_RS17350	COG1074	ATP-dependent DNA helicase activity
I9190_RS17365	COG2009	succinate dehydrogenase
I9190_RS17375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9190_RS17385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I9190_RS17420	COG0625	glutathione transferase activity
I9190_RS17425	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I9190_RS17450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I9190_RS17465	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_RS17475	COG0732	type I restriction modification DNA specificity domain
I9190_RS17485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_RS17565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I9190_RS17590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I9190_RS17600	COG0084	hydrolase, TatD family'
I9190_RS17615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I9190_RS17640	COG2130	NADP-dependent
I9190_RS17645	COG1309	transcriptional regulator
I9190_RS17670	COG1979	alcohol dehydrogenase
I9190_RS17680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I9190_RS17695	COG0604	alcohol dehydrogenase
I9190_RS17695	COG3321	synthase
I9190_RS17700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I9190_RS17705	COG0583	DNA-binding transcription factor activity
I9190_RS17710	COG4221	oxidoreductase activity
I9190_RS17845	COG3539	Fimbrial protein
I9190_RS17855	COG3121	Chaperone
I9190_RS17865	COG3539	Fimbrial protein
I9190_RS17880	COG2198	Histidine kinase
I9190_RS17880	COG0643	Histidine kinase
I9190_RS17880	COG0784	Response regulator, receiver
I9190_RS17885	COG0840	transmembrane signaling receptor activity
I9190_RS17910	COG0442	prolyl-tRNA aminoacylation
I9190_RS17970	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I9190_RS17975	COG0489	protein tyrosine kinase activity
I9190_RS18010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_RS18010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_RS18050	COG2853	Lipoprotein
I9190_RS18065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I9190_RS18070	COG1846	Transcriptional regulator
I9190_RS18075	COG1764	response to oxidative stress
I9190_RS18110	COG3384	dioxygenase
I9190_RS18120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I9190_RS18150	COG4206	TonB-dependent receptor
I9190_RS18155	COG2096	Adenosyltransferase
I9190_RS18175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I9190_RS18185	COG2315	Protein conserved in bacteria
I9190_RS18190	COG0745	RESPONSE REGULATOR receiver
I9190_RS18195	COG2205	protein histidine kinase activity
I9190_RS18205	COG3028	Belongs to the UPF0307 family
I9190_RS18210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I9190_RS18215	COG1660	Displays ATPase and GTPase activities
I9190_RS18220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I9190_RS18230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I9190_RS18235	COG0617	tRNA 3'-terminal CCA addition
I9190_RS18240	COG1555	photosystem II stabilization
I9190_RS18245	COG3956	TIGRFAM MazG family protein
I9190_RS18260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I9190_RS18280	COG0784	Response regulator, receiver
I9190_RS18280	COG2205	protein histidine kinase activity
I9190_RS18280	COG5002	protein histidine kinase activity
I9190_RS18285	COG1024	Enoyl-CoA hydratase
I9190_RS18290	COG2084	Dehydrogenase
I9190_RS18295	COG3622	Belongs to the hyi family
I9190_RS18305	COG0004	ammonium transporteR
I9190_RS18340	COG1426	Protein conserved in bacteria
I9190_RS18345	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I9190_RS18385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I9190_RS18390	COG0440	acetolactate synthase activity
I9190_RS18395	COG0028	Belongs to the TPP enzyme family
I9190_RS18400	COG1309	transcriptional regulator
I9190_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I9190_RS18435	COG1136	(ABC) transporter
I9190_RS18435	COG0577	efflux transmembrane transporter activity
I9190_RS18440	COG1538	Outer membrane efflux protein
I9190_RS18465	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_RS18470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_RS18475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I9190_RS18500	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I9190_RS18505	COG1162	GTPase activity
I9190_RS18515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I9190_RS18550	COG3783	Cytochrome b(562)
I9190_RS18555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I9190_RS18560	COG2003	Belongs to the UPF0758 family
I9190_RS18565	COG3781	membrane
I9190_RS18600	COG1946	Acyl-CoA thioesterase
I9190_RS18620	COG1295	ribonuclease BN
I9190_RS18625	COG0697	spore germination
I9190_RS18655	COG0179	Fumarylacetoacetate (FAA) hydrolase
I9190_RS18680	COG2814	Major facilitator Superfamily
I9190_RS18690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_RS18695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I9190_RS18705	COG0765	amino acid transport
I9190_RS18710	COG0765	amino acid transport
I9190_RS18740	COG0557	exoribonuclease II activity
I9190_RS18755	COG0339	signal peptide processing
I9190_RS18760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I9190_RS18805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I9190_RS18810	COG1960	acyl-CoA dehydrogenase activity
I9190_RS18815	COG2072	flavoprotein involved in K transport
I9190_RS18820	COG0203	ribosomal protein L17
I9190_RS18825	COG0202	RNA polymerase activity
I9190_RS18830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I9190_RS18840	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I9190_RS18865	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I9190_RS18880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I9190_RS18900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I9190_RS18930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I9190_RS18945	COG0088	Forms part of the polypeptide exit tunnel
I9190_RS18950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I9190_RS18955	COG0051	transcription antitermination factor activity, RNA binding
I9190_RS18965	COG0626	cystathionine gamma-synthase activity
I9190_RS18970	COG0433	COG0433 Predicted ATPase
I9190_RS18975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I9190_RS18975	COG1017	nitric oxide dioxygenase activity
I9190_RS18985	COG1959	2 iron, 2 sulfur cluster binding
I9190_RS19000	COG1301	dicarboxylic acid transport
I9190_RS19005	COG1946	Acyl-CoA thioesterase
I9190_RS19010	COG2937	Belongs to the GPAT DAPAT family
I9190_RS19020	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I9190_RS19025	COG1040	competence protein
I9190_RS19030	COG0494	nUDIX hydrolase
I9190_RS19040	COG0598	Magnesium transport protein CorA
I9190_RS19055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I9190_RS19060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I9190_RS19065	COG1127	ABC transporter
I9190_RS19070	COG0513	Belongs to the DEAD box helicase family
I9190_RS19085	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I9190_RS19090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9190_RS19095	COG0408	coproporphyrinogen oxidase activity
I9190_RS19115	COG1960	acyl-CoA dehydrogenase activity
I9190_RS19125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I9190_RS19135	COG0534	Mate efflux family protein
I9190_RS19145	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9190_RS19150	COG0254	rRNA binding
I9190_RS19155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I9190_RS19185	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I9190_RS19225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I9190_RS19240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I9190_RS19250	COG0644	oxidoreductase
I9190_RS19250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I9190_RS19270	COG0425	Belongs to the sulfur carrier protein TusA family
I9190_RS19275	COG4535	Mg2 and Co2 transporter CorC
I9190_RS19280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I9190_RS19285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I9190_RS19310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I9190_RS19320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I9190_RS19335	COG0789	Transcriptional regulator
I9190_RS19340	COG2841	Protein conserved in bacteria
I9190_RS19345	COG0598	Magnesium transport protein CorA
I9190_RS19360	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I9190_RS19365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_RS19370	COG1074	ATP-dependent DNA helicase activity
I9190_RS19375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I9190_RS19400	COG2226	methyltransferase
I9190_RS19410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I9190_RS19425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I9190_RS19445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I9190_RS19445	COG2111	Na H antiporter
I9190_RS19450	COG1006	Multisubunit Na H antiporter MnhC subunit
I9190_RS19455	COG0651	ATP synthesis coupled electron transport
I9190_RS19460	COG1863	multisubunit Na H antiporter MnhE subunit
I9190_RS19465	COG2212	antiporter activity
I9190_RS19470	COG1320	monovalent cation:proton antiporter activity
I9190_RS19475	COG0307	riboflavin synthase, alpha
I9190_RS19485	COG0493	'glutamate synthase
I9190_RS19490	COG0069	glutamate synthase activity
I9190_RS19490	COG0067	glutamate synthase
I9190_RS19490	COG0070	glutamate synthase
I9190_RS19540	COG2226	methyltransferase
I9190_RS19545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I9190_RS19550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I9190_RS19555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I9190_RS19595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9190_RS19675	COG4221	oxidoreductase activity
I9190_RS19680	COG0583	DNA-binding transcription factor activity
I9190_RS19690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I9190_RS19690	COG3320	Male sterility
I9190_RS19695	COG0789	Transcriptional regulator
I9190_RS19720	COG0427	acetyl-CoA hydrolase
I9190_RS19765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I9190_RS19800	COG0697	spore germination
I9190_RS19815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I9190_RS19830	COG0488	(ABC) transporter
I9190_RS19845	COG0704	Plays a role in the regulation of phosphate uptake
I9190_RS19870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I9190_RS19875	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I9190_RS19880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I9190_RS19885	COG0772	Belongs to the SEDS family
I9190_RS19895	COG0586	Pfam SNARE associated Golgi protein
I9190_RS19910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9190_RS19910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I9190_RS19920	COG0004	ammonium transporteR
I9190_RS19925	COG0347	Belongs to the P(II) protein family
I9190_RS19935	COG0606	chelatase, subunit chli
I9190_RS19990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I9190_RS20005	COG0318	PFAM AMP-dependent synthetase and ligase
I9190_RS20020	COG0477	Major facilitator Superfamily
I9190_RS20030	COG2860	membrane
I9190_RS20040	COG1253	flavin adenine dinucleotide binding
I9190_RS20085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I9190_RS20095	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I9190_RS20100	COG3162	membrane
I9190_RS20105	COG2205	protein histidine kinase activity
I9190_RS20105	COG0784	Response regulator, receiver
I9190_RS20125	COG2133	pyrroloquinoline quinone binding
I9190_RS20165	COG1309	transcriptional regulator
I9190_RS20185	COG4771	TonB-dependent receptor
I9190_RS20200	COG1652	LysM domain
I9190_RS20205	COG0758	DNA mediated transformation
I9190_RS20210	COG0009	L-threonylcarbamoyladenylate synthase
I9190_RS20215	COG0697	spore germination
I9190_RS20220	COG1309	transcriptional regulator
I9190_RS20240	COG0386	Belongs to the glutathione peroxidase family
I9190_RS20275	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I9190_RS20285	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I9190_RS20305	COG0356	it plays a direct role in the translocation of protons across the membrane
I9190_RS20325	COG1121	(ABC) transporter
I9190_RS20330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I9190_RS20345	COG2837	iron assimilation
I9190_RS20385	COG0281	malic enzyme
I9190_RS20415	COG0745	RESPONSE REGULATOR receiver
I9190_RS20420	COG2205	protein histidine kinase activity
I9190_RS20425	COG4452	Inner membrane protein CreD
I9190_RS20450	COG2814	Major facilitator Superfamily
I9190_RS20460	COG0431	NADPH-dependent FMN reductase
I9190_RS20480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I9190_RS20490	COG0668	transmembrane transport
I9190_RS20495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I9190_RS20500	COG1519	Transferase
I9190_RS20505	COG1902	pentaerythritol trinitrate reductase activity
I9190_RS20525	COG1715	Restriction endonuclease
I9190_RS20530	COG0519	Catalyzes the synthesis of GMP from XMP
I9190_RS20530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I9190_RS20540	COG2259	Doxx family
I9190_RS20545	COG0586	Pfam SNARE associated Golgi protein
I9190_RS20555	COG1192	Involved in chromosome partitioning
I9190_RS20565	COG0271	Belongs to the BolA IbaG family
I9190_RS20585	COG0235	Class ii aldolase
I9190_RS20590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I9190_RS20605	COG1454	alcohol dehydrogenase
I9190_RS20640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I9190_RS20645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I9190_RS20660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I9190_RS20665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I9190_RS20670	COG1216	Glycosyl transferase, family 2
I9190_RS20700	COG2244	polysaccharide biosynthetic process
I9190_RS20725	COG1596	polysaccharide export
I9190_RS20755	COG3023	N-Acetylmuramoyl-L-alanine amidase
I9190_RS20845	COG0741	lytic transglycosylase activity
I9190_RS20845	COG0739	heme binding
I9190_RS20845	COG1196	nuclear chromosome segregation
I9190_RS21005	COG0582	viral genome integration into host DNA
I9190_RS21010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I9190_RS21020	COG2207	Transcriptional regulator
I9190_RS21040	COG1309	transcriptional regulator
I9190_RS21055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I9190_RS21060	COG0546	phosphoglycolate phosphatase activity
I9190_RS21065	COG1028	Short-chain dehydrogenase reductase Sdr
I9190_RS21090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I9190_RS21090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I9190_RS21095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_RS21100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I9190_RS21105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I9190_RS21110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_RS21115	COG1116	anion transmembrane transporter activity
I9190_RS21120	COG1309	transcriptional regulator
I9190_RS21260	COG0737	Belongs to the 5'-nucleotidase family
I9190_RS21265	COG2175	clavaminate synthase activity
I9190_RS21270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I9190_RS21275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I9190_RS21280	COG4521	taurine ABC transporter
I9190_RS21300	COG0443	Heat shock 70 kDa protein
I9190_RS21340	COG2951	lytic endotransglycosylase activity
I9190_RS21345	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I9190_RS21370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I9190_RS21380	COG2388	GCN5-related N-acetyl-transferase
I9190_RS21385	COG2388	GCN5-related N-acetyl-transferase
I9190_RS21390	COG2814	Major facilitator Superfamily
I9190_RS21395	COG1335	isochorismatase
I9190_RS21400	COG0861	Integral membrane protein TerC family
I9190_RS21415	COG0754	glutathionylspermidine amidase activity
I9190_RS21425	COG0402	S-adenosylhomocysteine deaminase activity
I9190_RS21435	COG2261	transglycosylase associated protein
I9190_RS21445	COG1230	cation diffusion facilitator family transporter
I9190_RS21470	COG0629	single-stranded DNA binding
I9190_RS21520	COG0706	membrane insertase activity
I9190_RS21525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I9190_RS21530	COG0594	ribonuclease P activity
I9190_RS21595	COG1373	ATPase (AAA superfamily
I9190_RS21640	COG1192	Involved in chromosome partitioning
I9190_RS21655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I9190_RS21665	COG0732	type I restriction modification DNA specificity domain
I9190_RS21670	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I9190_RS21675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I9190_RS21725	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I9190_RS21735	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I9190_RS21815	COG1538	Outer membrane efflux protein
I9190_RS21820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I9190_RS21830	COG0745	RESPONSE REGULATOR receiver
I9190_RS21835	COG2205	protein histidine kinase activity
I9190_RS21850	COG3173	Aminoglycoside phosphotransferase
I9190_RS21855	COG0488	(ABC) transporter
I9190_RS21860	COG2801	Transposase and inactivated derivatives
I9190_RS21880	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_RS21885	COG3657	addiction module killer protein
I9190_RS21940	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I9190_RS21945	COG3657	addiction module killer protein
I9190_RS21955	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I9190_RS21995	COG0210	DNA helicase
I9190_RS22015	COG0210	DNA helicase
I9190_RS22070	COG0582	viral genome integration into host DNA
I9190_RS22075	COG2369	cell adhesion
I9190_RS22120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair