locus-tag	class	description
KI216_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KI216_RS00010	COG0592	DNA-directed DNA polymerase activity
KI216_RS00020	COG0187	DNA topoisomerase II activity
KI216_RS00030	COG0488	(ABC) transporter
KI216_RS00080	COG0657	acetylesterase activity
KI216_RS00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KI216_RS00120	COG2814	Major facilitator Superfamily
KI216_RS00130	COG0733	neurotransmitter:sodium symporter activity
KI216_RS00140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KI216_RS00170	COG0129	dihydroxy-acid dehydratase activity
KI216_RS00190	COG1477	protein flavinylation
KI216_RS00200	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KI216_RS00215	COG2233	PERMEase
KI216_RS00225	COG1309	transcriptional regulator
KI216_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS00250	COG3307	-O-antigen
KI216_RS00255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KI216_RS00275	COG1064	alcohol dehydrogenase
KI216_RS00280	COG2818	Glycosylase
KI216_RS00300	COG0537	adenosine 5'-monophosphoramidase activity
KI216_RS00330	COG1596	polysaccharide export
KI216_RS00335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KI216_RS00350	COG0438	transferase activity, transferring glycosyl groups
KI216_RS00355	COG0438	transferase activity, transferring glycosyl groups
KI216_RS00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KI216_RS00370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KI216_RS00385	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KI216_RS00400	COG1045	serine acetyltransferase
KI216_RS00410	COG0438	transferase activity, transferring glycosyl groups
KI216_RS00425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KI216_RS00430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KI216_RS00445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KI216_RS00450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KI216_RS00455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KI216_RS00465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KI216_RS00470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KI216_RS00510	COG1454	alcohol dehydrogenase
KI216_RS00535	COG0477	Major facilitator Superfamily
KI216_RS00555	COG0271	Belongs to the BolA IbaG family
KI216_RS00565	COG1192	Involved in chromosome partitioning
KI216_RS00580	COG0586	Pfam SNARE associated Golgi protein
KI216_RS00585	COG2259	Doxx family
KI216_RS00590	COG0519	Catalyzes the synthesis of GMP from XMP
KI216_RS00590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KI216_RS00605	COG3706	GGDEF domain
KI216_RS00670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KI216_RS00675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KI216_RS00680	COG1116	anion transmembrane transporter activity
KI216_RS00690	COG0534	Mate efflux family protein
KI216_RS00695	COG0436	Aminotransferase
KI216_RS00720	COG2837	iron assimilation
KI216_RS00730	COG2318	DinB family
KI216_RS00735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KI216_RS00740	COG1121	(ABC) transporter
KI216_RS00790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KI216_RS00825	COG0386	Belongs to the glutathione peroxidase family
KI216_RS00835	COG0697	spore germination
KI216_RS00845	COG0758	DNA mediated transformation
KI216_RS00875	COG1309	transcriptional regulator
KI216_RS00930	COG4452	Inner membrane protein CreD
KI216_RS00935	COG2205	protein histidine kinase activity
KI216_RS00945	COG0745	RESPONSE REGULATOR receiver
KI216_RS00950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KI216_RS00965	COG2814	Major facilitator Superfamily
KI216_RS00980	COG1253	flavin adenine dinucleotide binding
KI216_RS00990	COG2860	membrane
KI216_RS00995	COG0477	Major facilitator Superfamily
KI216_RS01000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KI216_RS01005	COG0318	PFAM AMP-dependent synthetase and ligase
KI216_RS01020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KI216_RS01040	COG0606	chelatase, subunit chli
KI216_RS01050	COG0347	Belongs to the P(II) protein family
KI216_RS01055	COG0004	ammonium transporteR
KI216_RS01065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KI216_RS01065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KI216_RS01080	COG0586	Pfam SNARE associated Golgi protein
KI216_RS01105	COG0795	lipopolysaccharide-transporting ATPase activity
KI216_RS01110	COG0795	lipopolysaccharide-transporting ATPase activity
KI216_RS01115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KI216_RS01120	COG0793	Belongs to the peptidase S41A family
KI216_RS01135	COG2197	response regulator
KI216_RS01140	COG1686	Belongs to the peptidase S11 family
KI216_RS01145	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KI216_RS01160	COG4974	Belongs to the 'phage' integrase family
KI216_RS01185	COG0772	Belongs to the SEDS family
KI216_RS01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KI216_RS01195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KI216_RS01200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KI216_RS01205	COG0494	nUDIX hydrolase
KI216_RS01210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KI216_RS01220	COG1538	Outer membrane efflux protein
KI216_RS01230	COG1132	(ABC) transporter
KI216_RS01260	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KI216_RS01270	COG0497	DNA recombination
KI216_RS01275	COG3123	guanosine phosphorylase activity
KI216_RS01280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KI216_RS01290	COG0237	dephospho-CoA kinase activity
KI216_RS01345	COG0779	Required for maturation of 30S ribosomal subunits
KI216_RS01350	COG0195	Participates in both transcription termination and antitermination
KI216_RS01355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KI216_RS01360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KI216_RS01370	COG1320	monovalent cation:proton antiporter activity
KI216_RS01375	COG2212	antiporter activity
KI216_RS01380	COG1863	multisubunit Na H antiporter MnhE subunit
KI216_RS01385	COG0651	ATP synthesis coupled electron transport
KI216_RS01390	COG1006	Multisubunit Na H antiporter MnhC subunit
KI216_RS01395	COG2111	Na H antiporter
KI216_RS01395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KI216_RS01410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KI216_RS01415	COG4221	oxidoreductase activity
KI216_RS01420	COG2873	o-acetylhomoserine
KI216_RS01425	COG0488	(ABC) transporter
KI216_RS01465	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KI216_RS01470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KI216_RS01495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KI216_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KI216_RS01505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KI216_RS01510	COG2226	methyltransferase
KI216_RS01560	COG0069	glutamate synthase activity
KI216_RS01560	COG0067	glutamate synthase
KI216_RS01560	COG0070	glutamate synthase
KI216_RS01565	COG0493	'glutamate synthase
KI216_RS01575	COG1704	LemA family
KI216_RS01580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KI216_RS01625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KI216_RS01630	COG1758	RNA polymerase activity
KI216_RS01635	COG0194	GDP metabolic process
KI216_RS01680	COG0228	four-way junction DNA binding
KI216_RS01685	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KI216_RS01705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KI216_RS01710	COG5380	lipid catabolic process
KI216_RS01715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KI216_RS01725	COG5006	permease, DMT superfamily
KI216_RS01735	COG5006	permease, DMT superfamily
KI216_RS01740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KI216_RS01745	COG0277	FAD linked oxidase domain protein
KI216_RS01775	COG2814	Major facilitator Superfamily
KI216_RS01785	COG1289	transmembrane transporter activity
KI216_RS01790	COG2032	superoxide dismutase activity
KI216_RS01795	COG0628	permease
KI216_RS01800	COG1192	Involved in chromosome partitioning
KI216_RS01815	COG2226	methyltransferase
KI216_RS01835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KI216_RS01840	COG0254	rRNA binding
KI216_RS01845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KI216_RS01855	COG0534	Mate efflux family protein
KI216_RS01865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KI216_RS01875	COG1960	acyl-CoA dehydrogenase activity
KI216_RS01895	COG0408	coproporphyrinogen oxidase activity
KI216_RS01900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KI216_RS01930	COG1127	ABC transporter
KI216_RS01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
KI216_RS01955	COG0598	Magnesium transport protein CorA
KI216_RS01970	COG1040	competence protein
KI216_RS01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KI216_RS01990	COG2937	Belongs to the GPAT DAPAT family
KI216_RS01995	COG1946	Acyl-CoA thioesterase
KI216_RS02000	COG1301	dicarboxylic acid transport
KI216_RS02020	COG1959	2 iron, 2 sulfur cluster binding
KI216_RS02030	COG0433	COG0433 Predicted ATPase
KI216_RS02045	COG0051	transcription antitermination factor activity, RNA binding
KI216_RS02050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KI216_RS02070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KI216_RS02120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KI216_RS02125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KI216_RS02135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KI216_RS02175	COG0202	RNA polymerase activity
KI216_RS02180	COG0203	ribosomal protein L17
KI216_RS02185	COG2072	flavoprotein involved in K transport
KI216_RS02195	COG1960	acyl-CoA dehydrogenase activity
KI216_RS02200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
KI216_RS02230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
KI216_RS02235	COG0339	signal peptide processing
KI216_RS02240	COG0557	exoribonuclease II activity
KI216_RS02280	COG0179	Fumarylacetoacetate (FAA) hydrolase
KI216_RS02295	COG1295	ribonuclease BN
KI216_RS02355	COG1702	phosphate starvation-inducible protein PhoH
KI216_RS02360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KI216_RS02365	COG1196	nuclear chromosome segregation
KI216_RS02365	COG0741	lytic transglycosylase activity
KI216_RS02365	COG0739	heme binding
KI216_RS02400	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
KI216_RS02405	COG1183	phosphatidylcholine synthase activity
KI216_RS02440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KI216_RS02470	COG1607	acyl-coa hydrolase
KI216_RS02485	COG1666	GTP binding
KI216_RS02505	COG2350	Protein conserved in bacteria
KI216_RS02515	COG0613	PHP domain protein
KI216_RS02520	COG3781	membrane
KI216_RS02530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KI216_RS02540	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KI216_RS02635	COG0640	Transcriptional regulator
KI216_RS02645	COG0798	PFAM Bile acid sodium symporter
KI216_RS02650	COG0431	NADPH-dependent FMN reductase
KI216_RS02655	COG0492	ferredoxin-NADP+ reductase activity
KI216_RS02660	COG2072	flavoprotein involved in K transport
KI216_RS02670	COG2072	flavoprotein involved in K transport
KI216_RS02695	COG2814	Major facilitator Superfamily
KI216_RS02700	COG0697	spore germination
KI216_RS02720	COG0004	ammonium transporteR
KI216_RS02735	COG3622	Belongs to the hyi family
KI216_RS02740	COG2084	Dehydrogenase
KI216_RS02750	COG5002	protein histidine kinase activity
KI216_RS02750	COG0784	Response regulator, receiver
KI216_RS02750	COG2205	protein histidine kinase activity
KI216_RS02770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KI216_RS02790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KI216_RS02800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KI216_RS02815	COG2986	histidine ammonia-lyase
KI216_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS02860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KI216_RS02870	COG0736	holo-[acyl-carrier-protein] synthase activity
KI216_RS02885	COG1862	Preprotein translocase
KI216_RS02890	COG0343	queuine tRNA-ribosyltransferase activity
KI216_RS02900	COG1704	LemA family
KI216_RS02910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KI216_RS02930	COG5002	protein histidine kinase activity
KI216_RS02935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
KI216_RS02955	COG0726	polysaccharide deacetylase
KI216_RS02965	COG0438	transferase activity, transferring glycosyl groups
KI216_RS02985	COG1088	dTDP-glucose 4,6-dehydratase activity
KI216_RS02990	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KI216_RS03005	COG1216	Glycosyl transferase, family 2
KI216_RS03020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
KI216_RS03050	COG3223	Belongs to the PsiE family
KI216_RS03060	COG1960	acyl-CoA dehydrogenase activity
KI216_RS03065	COG1960	acyl-CoA dehydrogenase activity
KI216_RS03075	COG2205	protein histidine kinase activity
KI216_RS03080	COG0745	RESPONSE REGULATOR receiver
KI216_RS03090	COG1113	amino acid transport
KI216_RS03110	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
KI216_RS03135	COG2096	Adenosyltransferase
KI216_RS03140	COG4206	TonB-dependent receptor
KI216_RS03145	COG4206	TonB-dependent receptor
KI216_RS03195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KI216_RS03200	COG0285	dihydrofolate synthase activity
KI216_RS03220	COG0450	alkyl hydroperoxide reductase
KI216_RS03235	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KI216_RS03240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KI216_RS03330	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KI216_RS03335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KI216_RS03385	COG0494	nUDIX hydrolase
KI216_RS03390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KI216_RS03395	COG1214	PFAM Peptidase M22, glycoprotease
KI216_RS03400	COG1968	undecaprenyl-diphosphatase activity
KI216_RS03420	COG0596	Alpha beta hydrolase
KI216_RS03425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
KI216_RS03430	COG4269	membrane
KI216_RS03445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KI216_RS03455	COG2132	Multicopper oxidase
KI216_RS03480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KI216_RS03495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KI216_RS03510	COG3121	Chaperone
KI216_RS03515	COG3188	usher protein
KI216_RS03535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KI216_RS03540	COG3545	Serine hydrolase
KI216_RS03555	COG0730	response to heat
KI216_RS03565	COG1196	nuclear chromosome segregation
KI216_RS03575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KI216_RS03580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KI216_RS03585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
KI216_RS03590	COG2193	ferroxidase activity
KI216_RS03595	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KI216_RS03610	COG2226	methyltransferase
KI216_RS03610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KI216_RS03610	COG0596	Alpha beta hydrolase
KI216_RS03645	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KI216_RS03650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KI216_RS03665	COG0009	L-threonylcarbamoyladenylate synthase
KI216_RS03670	COG3101	peptidyl-lysine hydroxylation
KI216_RS03675	COG1399	metal-binding, possibly nucleic acid-binding protein
KI216_RS03680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KI216_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS03700	COG1652	LysM domain
KI216_RS03710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KI216_RS03720	COG0251	oxidation-reduction process
KI216_RS03725	COG1113	amino acid transport
KI216_RS03735	COG1981	membrane
KI216_RS03775	COG0456	acetyltransferase
KI216_RS03780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
KI216_RS03785	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
KI216_RS03790	COG0492	ferredoxin-NADP+ reductase activity
KI216_RS03795	COG1674	ftsk spoiiie
KI216_RS03795	COG0531	amino acid
KI216_RS03805	COG0583	DNA-binding transcription factor activity
KI216_RS03840	COG0204	Acyl-transferase
KI216_RS03850	COG0210	DNA helicase
KI216_RS03865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KI216_RS03875	COG0121	glutamine amidotransferase
KI216_RS03890	COG2914	Belongs to the UPF0125 (RnfH) family
KI216_RS03895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KI216_RS03900	COG0735	belongs to the Fur family
KI216_RS03935	COG0420	3'-5' exonuclease activity
KI216_RS03945	COG5001	Diguanylate cyclase
KI216_RS03945	COG2203	Gaf domain
KI216_RS03945	COG3706	GGDEF domain
KI216_RS03945	COG4251	negative regulation of phosphorylation
KI216_RS03975	COG2050	protein possibly involved in aromatic compounds catabolism
KI216_RS03980	COG1566	PFAM secretion protein HlyD family protein
KI216_RS03985	COG2814	Major facilitator Superfamily
KI216_RS03990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KI216_RS04055	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
KI216_RS04085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KI216_RS04095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KI216_RS04100	COG1077	Cell shape determining protein MreB Mrl
KI216_RS04105	COG1792	Involved in formation and maintenance of cell shape
KI216_RS04110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KI216_RS04115	COG0424	maF-like protein
KI216_RS04120	COG1530	ribonuclease E activity
KI216_RS04130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KI216_RS04165	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KI216_RS04170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KI216_RS04175	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
KI216_RS04180	COG2205	protein histidine kinase activity
KI216_RS04185	COG0745	RESPONSE REGULATOR receiver
KI216_RS04210	COG1113	amino acid transport
KI216_RS04215	COG2828	Protein conserved in bacteria
KI216_RS04220	COG0142	geranyltranstransferase activity
KI216_RS04225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KI216_RS04240	COG1752	Esterase of the alpha-beta hydrolase superfamily
KI216_RS04265	COG0745	RESPONSE REGULATOR receiver
KI216_RS04270	COG0642	Histidine kinase
KI216_RS04285	COG0004	ammonium transporteR
KI216_RS04290	COG1126	abc transporter atp-binding protein
KI216_RS04295	COG0765	amino acid transport
KI216_RS04300	COG0765	amino acid transport
KI216_RS04320	COG2852	Protein conserved in bacteria
KI216_RS04330	COG0525	valine-tRNA ligase activity
KI216_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS04350	COG0393	Putative heavy-metal-binding
KI216_RS04355	COG0393	Putative heavy-metal-binding
KI216_RS04360	COG1538	Outer membrane efflux protein
KI216_RS04365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KI216_RS04370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS04375	COG0671	phosphoesterase, PA-phosphatase related
KI216_RS04405	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KI216_RS04415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KI216_RS04420	COG1648	precorrin-2 dehydrogenase activity
KI216_RS04420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KI216_RS04425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KI216_RS04435	COG0531	amino acid
KI216_RS04450	COG0321	lipoyl(octanoyl) transferase activity
KI216_RS04480	COG0586	Pfam SNARE associated Golgi protein
KI216_RS04520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KI216_RS04550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KI216_RS04580	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
KI216_RS04595	COG0358	DNA primase activity
KI216_RS04605	COG0564	pseudouridine synthase activity
KI216_RS04620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KI216_RS04630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KI216_RS04660	COG0110	maltose O-acetyltransferase activity
KI216_RS04675	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KI216_RS04680	COG0505	Belongs to the CarA family
KI216_RS04700	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
KI216_RS04705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KI216_RS04710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KI216_RS04740	COG2851	Citrate transporter
KI216_RS04745	COG1253	flavin adenine dinucleotide binding
KI216_RS04790	COG1196	nuclear chromosome segregation
KI216_RS04790	COG0741	lytic transglycosylase activity
KI216_RS04790	COG0739	heme binding
KI216_RS04795	COG0037	tRNA processing
KI216_RS04805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
KI216_RS04810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KI216_RS04840	COG1741	Belongs to the pirin family
KI216_RS04875	COG3706	GGDEF domain
KI216_RS04890	COG0302	gtp cyclohydrolase
KI216_RS04910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KI216_RS04915	COG0512	Glutamine amidotransferase of anthranilate synthase
KI216_RS04920	COG0174	glutamine synthetase
KI216_RS04930	COG3161	chorismate lyase activity
KI216_RS04935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
KI216_RS04945	COG0583	DNA-binding transcription factor activity
KI216_RS04970	COG3733	amine oxidase
KI216_RS04980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KI216_RS04990	COG0583	DNA-binding transcription factor activity
KI216_RS05000	COG0625	glutathione transferase activity
KI216_RS05070	COG0436	Aminotransferase
KI216_RS05080	COG0052	Belongs to the universal ribosomal protein uS2 family
KI216_RS05120	COG2951	lytic endotransglycosylase activity
KI216_RS05135	COG0842	Transport permease protein
KI216_RS05140	COG1131	(ABC) transporter
KI216_RS05155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KI216_RS05165	COG1294	oxidase, subunit
KI216_RS05170	COG1271	oxidase subunit
KI216_RS05180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KI216_RS05200	COG4774	siderophore transport
KI216_RS05215	COG1414	Transcriptional regulator
KI216_RS05220	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KI216_RS05225	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KI216_RS05230	COG0183	Belongs to the thiolase family
KI216_RS05235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KI216_RS05240	COG0596	Alpha beta hydrolase
KI216_RS05245	COG2271	Major facilitator Superfamily
KI216_RS05250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KI216_RS05255	COG3485	protocatechuate 3,4-dioxygenase
KI216_RS05260	COG3485	protocatechuate 3,4-dioxygenase
KI216_RS05265	COG0710	3-dehydroquinate dehydratase activity
KI216_RS05270	COG3420	alginic acid biosynthetic process
KI216_RS05275	COG3659	wide pore channel activity
KI216_RS05280	COG4993	Dehydrogenase
KI216_RS05315	COG1968	undecaprenyl-diphosphatase activity
KI216_RS05325	COG2175	clavaminate synthase activity
KI216_RS05330	COG3246	L-lysine catabolic process to acetate
KI216_RS05335	COG2814	Major facilitator Superfamily
KI216_RS05345	COG2146	nitrite reductase [NAD(P)H] activity
KI216_RS05350	COG2855	membrane
KI216_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
KI216_RS05390	COG0372	Belongs to the citrate synthase family
KI216_RS05415	COG1113	amino acid transport
KI216_RS05425	COG0010	Belongs to the arginase family
KI216_RS05430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KI216_RS05465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KI216_RS05490	COG3634	alkyl hydroperoxide reductase activity
KI216_RS05495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
KI216_RS05500	COG0826	peptidase U32
KI216_RS05505	COG0640	Transcriptional regulator
KI216_RS05510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KI216_RS05515	COG0798	PFAM Bile acid sodium symporter
KI216_RS05520	COG0431	NADPH-dependent FMN reductase
KI216_RS05525	COG0789	Transcriptional regulator
KI216_RS05560	COG4993	Dehydrogenase
KI216_RS05570	COG1720	tRNA m6t6A37 methyltransferase activity
KI216_RS05580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KI216_RS05605	COG0494	nUDIX hydrolase
KI216_RS05615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KI216_RS05620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KI216_RS05625	COG3139	Protein of unknown function (DUF1315)
KI216_RS05640	COG1301	dicarboxylic acid transport
KI216_RS05645	COG1960	acyl-CoA dehydrogenase activity
KI216_RS05650	COG0693	protein deglycase activity
KI216_RS05660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KI216_RS05665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KI216_RS05695	COG2252	PERMEase
KI216_RS05700	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
KI216_RS05710	COG3038	cytochrome b561
KI216_RS05720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KI216_RS05730	COG0527	aspartate kinase activity
KI216_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KI216_RS05750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KI216_RS05765	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KI216_RS05770	COG1522	sequence-specific DNA binding
KI216_RS05785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KI216_RS05805	COG1252	NADH dehydrogenase
KI216_RS05810	COG1686	Belongs to the peptidase S11 family
KI216_RS05855	COG0436	Aminotransferase
KI216_RS05860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KI216_RS05865	COG0386	Belongs to the glutathione peroxidase family
KI216_RS05875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
KI216_RS05890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KI216_RS05920	COG0012	GTP binding
KI216_RS05925	COG2011	ABC-type metal ion transport system permease component
KI216_RS05930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KI216_RS05935	COG1464	Belongs to the NlpA lipoprotein family
KI216_RS05940	COG1464	Belongs to the NlpA lipoprotein family
KI216_RS05980	COG0204	Acyl-transferase
KI216_RS06000	COG1538	Outer membrane efflux protein
KI216_RS06030	COG4774	siderophore transport
KI216_RS06045	COG2814	Major facilitator Superfamily
KI216_RS06055	COG0179	Fumarylacetoacetate (FAA) hydrolase
KI216_RS06065	COG1012	belongs to the aldehyde dehydrogenase family
KI216_RS06070	COG3384	dioxygenase
KI216_RS06080	COG3971	2-oxopent-4-enoate hydratase activity
KI216_RS06105	COG0477	Major facilitator Superfamily
KI216_RS06120	COG1960	acyl-CoA dehydrogenase activity
KI216_RS06125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KI216_RS06130	COG1053	succinate dehydrogenase
KI216_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS06155	COG2271	Major facilitator Superfamily
KI216_RS06165	COG1846	Transcriptional regulator
KI216_RS06170	COG2814	Major facilitator Superfamily
KI216_RS06195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KI216_RS06195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KI216_RS06200	COG1254	Belongs to the acylphosphatase family
KI216_RS06235	COG3634	alkyl hydroperoxide reductase activity
KI216_RS06265	COG1643	Atp-dependent helicase
KI216_RS06285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KI216_RS06290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KI216_RS06295	COG0583	DNA-binding transcription factor activity
KI216_RS06305	COG1765	OsmC-like protein
KI216_RS06315	COG0667	Aldo Keto reductase
KI216_RS06320	COG0542	response to heat
KI216_RS06365	COG0540	Belongs to the ATCase OTCase family
KI216_RS06375	COG3047	cAMP biosynthetic process
KI216_RS06375	COG2885	chlorophyll binding
KI216_RS06405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KI216_RS06410	COG4585	Histidine kinase
KI216_RS06420	COG0659	secondary active sulfate transmembrane transporter activity
KI216_RS06425	COG0625	glutathione transferase activity
KI216_RS06430	COG2249	NAD(P)H dehydrogenase (quinone) activity
KI216_RS06455	COG2363	Small membrane protein
KI216_RS06475	COG1278	Cold shock
KI216_RS06480	COG0513	Belongs to the DEAD box helicase family
KI216_RS06515	COG0167	dihydroorotate dehydrogenase activity
KI216_RS06565	COG1610	YqeY-like protein
KI216_RS06590	COG0515	serine threonine protein kinase
KI216_RS06590	COG2815	serine threonine protein kinase
KI216_RS06650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KI216_RS06655	COG1823	symporter activity
KI216_RS06665	COG0612	Peptidase, M16
KI216_RS06685	COG3025	triphosphatase activity
KI216_RS06700	COG0352	thiamine-phosphate diphosphorylase activity
KI216_RS06710	COG3193	protein, possibly involved in utilization of glycolate and propanediol
KI216_RS06720	COG1309	transcriptional regulator
KI216_RS06725	COG0783	Belongs to the Dps family
KI216_RS06780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
KI216_RS06810	COG0726	polysaccharide deacetylase
KI216_RS06810	COG1649	PFAM Uncharacterised BCR, COG1649
KI216_RS06815	COG1215	transferase activity, transferring glycosyl groups
KI216_RS06840	COG2070	2-Nitropropane dioxygenase
KI216_RS06860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KI216_RS06865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KI216_RS06900	COG1280	lysine exporter protein (LysE YggA)
KI216_RS06905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KI216_RS06905	COG0519	Catalyzes the synthesis of GMP from XMP
KI216_RS06935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
KI216_RS06945	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
KI216_RS06950	COG1137	ATPase activity
KI216_RS06980	COG0589	response to stress
KI216_RS06985	COG4122	O-methyltransferase activity
KI216_RS06995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KI216_RS07005	COG3706	GGDEF domain
KI216_RS07045	COG2011	ABC-type metal ion transport system permease component
KI216_RS07050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KI216_RS07055	COG1464	Belongs to the NlpA lipoprotein family
KI216_RS07085	COG0138	bifunctional purine biosynthesis protein purh
KI216_RS07090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
KI216_RS07130	COG2814	Major facilitator Superfamily
KI216_RS07145	COG3852	Histidine kinase
KI216_RS07165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KI216_RS07170	COG0575	Belongs to the CDS family
KI216_RS07185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KI216_RS07195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KI216_RS07205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KI216_RS07220	COG2137	regulation of response to DNA damage stimulus
KI216_RS07230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KI216_RS07235	COG1011	Hydrolase
KI216_RS07240	COG1218	3'(2'),5'-bisphosphate nucleotidase
KI216_RS07265	COG0702	epimerase
KI216_RS07270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KI216_RS07285	COG4585	Histidine kinase
KI216_RS07290	COG2850	peptidyl-arginine hydroxylation
KI216_RS07295	COG0424	maF-like protein
KI216_RS07320	COG0697	spore germination
KI216_RS07345	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KI216_RS07355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KI216_RS07360	COG3781	membrane
KI216_RS07405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KI216_RS07410	COG1027	Aspartate ammonia-lyase
KI216_RS07420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KI216_RS07450	COG0316	Belongs to the HesB IscA family
KI216_RS07455	COG0822	iron-sulfur transferase activity
KI216_RS07485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KI216_RS07525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KI216_RS07550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KI216_RS07555	COG0569	domain protein
KI216_RS07570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KI216_RS07575	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KI216_RS07595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
KI216_RS07600	COG0542	response to heat
KI216_RS07630	COG0372	Belongs to the citrate synthase family
KI216_RS07660	COG0415	Belongs to the DNA photolyase family
KI216_RS07670	COG0281	malic enzyme
KI216_RS07730	COG0789	Transcriptional regulator
KI216_RS07750	COG1846	Transcriptional regulator
KI216_RS07755	COG2814	Major facilitator Superfamily
KI216_RS07765	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS07775	COG2814	Major facilitator Superfamily
KI216_RS07780	COG2199	diguanylate cyclase activity
KI216_RS07790	COG0439	Biotin carboxylase
KI216_RS07855	COG0596	Alpha beta hydrolase
KI216_RS07955	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS07960	COG2814	Major facilitator Superfamily
KI216_RS07965	COG2271	Major facilitator Superfamily
KI216_RS07970	COG2271	Major facilitator Superfamily
KI216_RS07975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KI216_RS08005	COG2267	carboxylic ester hydrolase activity
KI216_RS08015	COG0596	Alpha beta hydrolase
KI216_RS08025	COG0583	DNA-binding transcription factor activity
KI216_RS08050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KI216_RS08070	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KI216_RS08085	COG3971	2-oxopent-4-enoate hydratase activity
KI216_RS08090	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KI216_RS08095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KI216_RS08105	COG1116	anion transmembrane transporter activity
KI216_RS08105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KI216_RS08115	COG2223	nitrite transmembrane transporter activity
KI216_RS08120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KI216_RS08125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KI216_RS08130	COG0243	molybdopterin cofactor binding
KI216_RS08140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KI216_RS08150	COG0314	molybdopterin synthase activity
KI216_RS08155	COG0315	cyclic pyranopterin monophosphate synthase activity
KI216_RS08155	COG0521	Mo-molybdopterin cofactor biosynthetic process
KI216_RS08160	COG0303	'Molybdopterin
KI216_RS08165	COG0725	ABC transporter, periplasmic molybdate-binding protein
KI216_RS08170	COG4149	molybdate abc transporter
KI216_RS08175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
KI216_RS08180	COG0745	RESPONSE REGULATOR receiver
KI216_RS08185	COG5002	protein histidine kinase activity
KI216_RS08195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KI216_RS08200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS08210	COG0842	Transport permease protein
KI216_RS08215	COG0842	Transport permease protein
KI216_RS08220	COG1131	(ABC) transporter
KI216_RS08235	COG1944	ATP diphosphatase activity
KI216_RS08240	COG2937	Belongs to the GPAT DAPAT family
KI216_RS08250	COG0318	PFAM AMP-dependent synthetase and ligase
KI216_RS08270	COG2814	Major facilitator Superfamily
KI216_RS08275	COG0583	DNA-binding transcription factor activity
KI216_RS08280	COG4948	Mandelate Racemase Muconate Lactonizing
KI216_RS08285	COG4829	muconolactone delta-isomerase
KI216_RS08295	COG4638	Rieske (2fe-2S)
KI216_RS08300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
KI216_RS08305	COG0543	2 iron, 2 sulfur cluster binding
KI216_RS08305	COG0633	Ferredoxin
KI216_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS08315	COG3135	benzoate transporter
KI216_RS08320	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KI216_RS08325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KI216_RS08330	COG0183	Belongs to the thiolase family
KI216_RS08335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KI216_RS08350	COG2814	Major facilitator Superfamily
KI216_RS08355	COG1960	acyl-CoA dehydrogenase activity
KI216_RS08365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KI216_RS08390	COG1959	2 iron, 2 sulfur cluster binding
KI216_RS08395	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KI216_RS08405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KI216_RS08415	COG0864	Transcriptional regulator
KI216_RS08435	COG0439	Biotin carboxylase
KI216_RS08450	COG0583	DNA-binding transcription factor activity
KI216_RS08465	COG0427	acetyl-CoA hydrolase
KI216_RS08470	COG0183	Belongs to the thiolase family
KI216_RS08475	COG1960	acyl-CoA dehydrogenase activity
KI216_RS08490	COG0789	Transcriptional regulator
KI216_RS08500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KI216_RS08505	COG0640	Transcriptional regulator
KI216_RS08525	COG3122	Protein conserved in bacteria
KI216_RS08545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KI216_RS08550	COG3135	benzoate transporter
KI216_RS08565	COG2161	toxin-antitoxin pair type II binding
KI216_RS08570	COG4115	mRNA cleavage
KI216_RS08585	COG1132	(ABC) transporter
KI216_RS08600	COG0509	glycine decarboxylation via glycine cleavage system
KI216_RS08605	COG3384	dioxygenase
KI216_RS08610	COG2814	Major facilitator Superfamily
KI216_RS08625	COG0488	(ABC) transporter
KI216_RS08640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
KI216_RS08645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KI216_RS08650	COG2226	methyltransferase
KI216_RS08665	COG0697	spore germination
KI216_RS08685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KI216_RS08685	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
KI216_RS08700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KI216_RS08730	COG1525	nuclease
KI216_RS08740	COG2814	Major facilitator Superfamily
KI216_RS08765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KI216_RS08770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KI216_RS08800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KI216_RS08820	COG2819	hydrolase of the alpha beta superfamily
KI216_RS08825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KI216_RS08850	COG0583	DNA-binding transcription factor activity
KI216_RS08855	COG1380	Effector of murein hydrolase LrgA
KI216_RS08860	COG1346	cytolysis
KI216_RS08875	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
KI216_RS08925	COG3433	isochorismatase activity
KI216_RS08925	COG1535	isochorismatase
KI216_RS08930	COG1021	2,3-dihydroxybenzoate-AMP ligase
KI216_RS08935	COG1169	isochorismate synthase
KI216_RS08940	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS08945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KI216_RS08955	COG2985	domain, Protein
KI216_RS08965	COG4716	Myosin-crossreactive antigen
KI216_RS08970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KI216_RS08985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KI216_RS08990	COG2207	Transcriptional regulator
KI216_RS08995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
KI216_RS09005	COG0730	response to heat
KI216_RS09080	COG1960	acyl-CoA dehydrogenase activity
KI216_RS09085	COG1960	acyl-CoA dehydrogenase activity
KI216_RS09145	COG0552	protein localization to endoplasmic reticulum
KI216_RS09150	COG0612	Peptidase, M16
KI216_RS09175	COG0517	IMP dehydrogenase activity
KI216_RS09175	COG0516	GMP reductase activity
KI216_RS09180	COG0133	tryptophan synthase activity
KI216_RS09195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KI216_RS09215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KI216_RS09245	COG0537	adenosine 5'-monophosphoramidase activity
KI216_RS09265	COG1294	oxidase, subunit
KI216_RS09270	COG4890	Cyd operon protein YbgT
KI216_RS09280	COG0772	Belongs to the SEDS family
KI216_RS09295	COG0148	phosphopyruvate hydratase activity
KI216_RS09315	COG0583	DNA-binding transcription factor activity
KI216_RS09320	COG0656	L-ascorbic acid biosynthetic process
KI216_RS09325	COG2814	Major facilitator Superfamily
KI216_RS09340	COG0446	pyridine nucleotide-disulphide oxidoreductase
KI216_RS09340	COG1902	pentaerythritol trinitrate reductase activity
KI216_RS09350	COG0596	Alpha beta hydrolase
KI216_RS09355	COG0583	DNA-binding transcription factor activity
KI216_RS09360	COG0583	DNA-binding transcription factor activity
KI216_RS09365	COG0024	Methionine aminopeptidase
KI216_RS09370	COG1114	Component of the transport system for branched-chain amino acids
KI216_RS09395	COG0786	glutamate:sodium symporter activity
KI216_RS09445	COG1570	exodeoxyribonuclease VII activity
KI216_RS09465	COG0729	surface antigen
KI216_RS09475	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
KI216_RS09500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KI216_RS09510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KI216_RS09520	COG2814	Major facilitator Superfamily
KI216_RS09525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KI216_RS09530	COG1960	acyl-CoA dehydrogenase activity
KI216_RS09550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KI216_RS09555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KI216_RS09560	COG2890	protein-(glutamine-N5) methyltransferase activity
KI216_RS09580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KI216_RS09585	COG4682	membrane
KI216_RS09610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KI216_RS09615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KI216_RS09620	COG1845	cytochrome c oxidase, subunit III
KI216_RS09625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KI216_RS09645	COG0360	Binds together with S18 to 16S ribosomal RNA
KI216_RS09660	COG0305	Participates in initiation and elongation during chromosome replication
KI216_RS09665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KI216_RS09675	COG1305	Transglutaminase-like
KI216_RS09685	COG2308	Evidence 4 Homologs of previously reported genes of
KI216_RS09695	COG0069	glutamate synthase activity
KI216_RS09715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KI216_RS09720	COG1454	alcohol dehydrogenase
KI216_RS09730	COG0824	Thioesterase
KI216_RS09735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KI216_RS09750	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KI216_RS09755	COG2030	dehydratase
KI216_RS09765	COG0183	Belongs to the thiolase family
KI216_RS09780	COG0583	DNA-binding transcription factor activity
KI216_RS09785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KI216_RS09795	COG3135	benzoate transporter
KI216_RS09800	COG1309	transcriptional regulator
KI216_RS09815	COG0589	response to stress
KI216_RS09825	COG1714	RDD family
KI216_RS09835	COG0308	aminopeptidase N
KI216_RS09860	COG1253	flavin adenine dinucleotide binding
KI216_RS09880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KI216_RS09885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
KI216_RS09900	COG2431	L-lysine efflux transmembrane transporter activity
KI216_RS09920	COG0776	regulation of translation
KI216_RS09945	COG1024	Enoyl-CoA hydratase
KI216_RS09950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KI216_RS09985	COG0084	hydrolase, TatD family'
KI216_RS10005	COG1663	tetraacyldisaccharide 4'-kinase activity
KI216_RS10010	COG1132	(ABC) transporter
KI216_RS10020	COG0811	peptide transport
KI216_RS10025	COG1475	DNA binding
KI216_RS10030	COG1192	Involved in chromosome partitioning
KI216_RS10040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KI216_RS10055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KI216_RS10060	COG1923	regulation of RNA biosynthetic process
KI216_RS10070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KI216_RS10075	COG0802	atpase or kinase
KI216_RS10080	COG0564	pseudouridine synthase activity
KI216_RS10100	COG2707	UPF0756 membrane protein
KI216_RS10105	COG0730	response to heat
KI216_RS10110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KI216_RS10145	COG0714	Associated with various cellular activities
KI216_RS10150	COG2879	small protein
KI216_RS10155	COG1966	Carbon starvation protein
KI216_RS10200	COG1067	ATP-dependent peptidase activity
KI216_RS10205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
KI216_RS10210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KI216_RS10215	COG0583	DNA-binding transcription factor activity
KI216_RS10220	COG4942	peptidase
KI216_RS10240	COG1686	Belongs to the peptidase S11 family
KI216_RS10245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KI216_RS10260	COG0482	sulfurtransferase activity
KI216_RS10265	COG2915	High frequency lysogenization protein hflD homolog
KI216_RS10300	COG0616	signal peptide processing
KI216_RS10305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KI216_RS10315	COG0573	inorganic phosphate transmembrane transporter activity
KI216_RS10320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KI216_RS10330	COG2271	Major facilitator Superfamily
KI216_RS10335	COG0076	glutamate decarboxylase activity
KI216_RS10340	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KI216_RS10350	COG4772	TonB-dependent receptor
KI216_RS10355	COG0671	phosphoesterase, PA-phosphatase related
KI216_RS10370	COG1733	regulation of RNA biosynthetic process
KI216_RS10375	COG0702	epimerase
KI216_RS10405	COG0556	nucleotide-excision repair
KI216_RS10415	COG3706	GGDEF domain
KI216_RS10440	COG2175	clavaminate synthase activity
KI216_RS10465	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KI216_RS10485	COG2233	PERMEase
KI216_RS10490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KI216_RS10495	COG0251	oxidation-reduction process
KI216_RS10500	COG1335	isochorismatase
KI216_RS10505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KI216_RS10510	COG0596	Alpha beta hydrolase
KI216_RS10520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KI216_RS10525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KI216_RS10530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KI216_RS10570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
KI216_RS10585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KI216_RS10590	COG0571	ribonuclease III activity
KI216_RS10600	COG0681	Belongs to the peptidase S26 family
KI216_RS10615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KI216_RS10645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KI216_RS10655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KI216_RS10660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KI216_RS10675	COG4208	sulfate ABC transporter
KI216_RS10680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KI216_RS10685	COG0583	DNA-binding transcription factor activity
KI216_RS10705	COG0602	queuosine metabolic process
KI216_RS10710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KI216_RS10725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KI216_RS10735	COG0583	DNA-binding transcription factor activity
KI216_RS10740	COG2353	YceI-like domain
KI216_RS10745	COG1051	belongs to the nudix hydrolase family
KI216_RS10745	COG1056	cytidyltransferase-related domain
KI216_RS10750	COG1024	Enoyl-CoA hydratase
KI216_RS10755	COG0778	Nitroreductase
KI216_RS10760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KI216_RS10760	COG3323	Protein of unknown function (DUF1653)
KI216_RS10770	COG0047	phosphoribosylformylglycinamidine synthase activity
KI216_RS10770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KI216_RS10795	COG2255	four-way junction helicase activity
KI216_RS10810	COG1473	amidohydrolase
KI216_RS10815	COG0824	Thioesterase
KI216_RS10840	COG0823	Involved in the tonB-independent uptake of proteins
KI216_RS10860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KI216_RS10895	COG0628	permease
KI216_RS10900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KI216_RS10905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KI216_RS10935	COG1136	(ABC) transporter
KI216_RS10950	COG0697	spore germination
KI216_RS10955	COG1671	Belongs to the UPF0178 family
KI216_RS10980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS10995	COG1301	dicarboxylic acid transport
KI216_RS11025	COG1280	lysine exporter protein (LysE YggA)
KI216_RS11030	COG1522	sequence-specific DNA binding
KI216_RS11050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
KI216_RS11055	COG0596	Alpha beta hydrolase
KI216_RS11065	COG0019	diaminopimelate decarboxylase activity
KI216_RS11075	COG1113	amino acid transport
KI216_RS11090	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
KI216_RS11105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
KI216_RS11115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KI216_RS11120	COG3300	MHYT domain
KI216_RS11120	COG5001	Diguanylate cyclase
KI216_RS11135	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
KI216_RS11195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KI216_RS11200	COG0842	Transport permease protein
KI216_RS11205	COG0842	Transport permease protein
KI216_RS11205	COG1129	ABC transporter
KI216_RS11210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS11235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KI216_RS11245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS11270	COG3712	iron ion homeostasis
KI216_RS11290	COG0446	pyridine nucleotide-disulphide oxidoreductase
KI216_RS11290	COG1902	pentaerythritol trinitrate reductase activity
KI216_RS11295	COG0277	FAD linked oxidase domain protein
KI216_RS11305	COG2186	Transcriptional regulator
KI216_RS11320	COG0697	spore germination
KI216_RS11325	COG0583	DNA-binding transcription factor activity
KI216_RS11335	COG3706	GGDEF domain
KI216_RS11340	COG0418	dihydroorotase activity
KI216_RS11345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KI216_RS11350	COG4771	TonB-dependent receptor
KI216_RS11355	COG0833	amino acid
KI216_RS11370	COG0833	amino acid
KI216_RS11395	COG0625	glutathione transferase activity
KI216_RS11405	COG4172	Belongs to the ABC transporter superfamily
KI216_RS11410	COG4239	(ABC) transporter, permease
KI216_RS11415	COG4174	ABC transporter (Permease)
KI216_RS11425	COG1388	LysM domain
KI216_RS11425	COG0741	lytic transglycosylase activity
KI216_RS11440	COG2816	NAD+ diphosphatase activity
KI216_RS11445	COG0657	acetylesterase activity
KI216_RS11480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KI216_RS11485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KI216_RS11490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KI216_RS11490	COG0456	acetyltransferase
KI216_RS11500	COG0006	proline dipeptidase activity
KI216_RS11540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KI216_RS11555	COG2234	aminopeptidase activity
KI216_RS11565	COG3384	dioxygenase
KI216_RS11575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KI216_RS11580	COG2878	Part of a membrane complex involved in electron transport
KI216_RS11585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KI216_RS11610	COG0768	penicillin binding
KI216_RS11615	COG0742	ribosomal rna small subunit methyltransferase
KI216_RS11645	COG3015	lipoprotein NlpE involved in copper resistance
KI216_RS11675	COG1597	lipid kinase activity
KI216_RS11680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
KI216_RS11695	COG0477	Major facilitator Superfamily
KI216_RS11700	COG0477	Major facilitator Superfamily
KI216_RS11715	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KI216_RS11745	COG0456	acetyltransferase
KI216_RS11765	COG1695	Transcriptional regulator
KI216_RS11800	COG1585	Membrane protein implicated in regulation of membrane protease activity
KI216_RS11805	COG2268	Band 7 protein
KI216_RS11810	COG1649	PFAM Uncharacterised BCR, COG1649
KI216_RS11810	COG0726	polysaccharide deacetylase
KI216_RS11820	COG1215	transferase activity, transferring glycosyl groups
KI216_RS11825	COG0726	polysaccharide deacetylase
KI216_RS11825	COG1649	PFAM Uncharacterised BCR, COG1649
KI216_RS11835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KI216_RS11845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KI216_RS11860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KI216_RS11865	COG1053	succinate dehydrogenase
KI216_RS11870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
KI216_RS11875	COG2009	succinate dehydrogenase
KI216_RS11885	COG2072	flavoprotein involved in K transport
KI216_RS11890	COG0300	oxidoreductase activity
KI216_RS11900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
KI216_RS11905	COG0714	Associated with various cellular activities
KI216_RS11955	COG2321	neutral zinc metallopeptidase
KI216_RS11960	COG2354	Protein conserved in bacteria
KI216_RS11990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KI216_RS11995	COG1773	rubredoxin
KI216_RS12000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KI216_RS12010	COG0583	DNA-binding transcription factor activity
KI216_RS12035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
KI216_RS12040	COG4181	ATPase activity
KI216_RS12065	COG4771	TonB-dependent receptor
KI216_RS12095	COG0306	phosphate transporter
KI216_RS12125	COG2223	nitrite transmembrane transporter activity
KI216_RS12130	COG2207	Transcriptional regulator
KI216_RS12135	COG0242	peptide deformylase activity
KI216_RS12150	COG0477	Major facilitator Superfamily
KI216_RS12190	COG2203	Gaf domain
KI216_RS12190	COG2199	diguanylate cyclase activity
KI216_RS12205	COG4681	YaeQ
KI216_RS12215	COG0523	cobalamin synthesis protein
KI216_RS12235	COG0583	DNA-binding transcription factor activity
KI216_RS12240	COG2814	Major facilitator Superfamily
KI216_RS12255	COG1607	acyl-coa hydrolase
KI216_RS12265	COG1752	Esterase of the alpha-beta hydrolase superfamily
KI216_RS12270	COG0786	glutamate:sodium symporter activity
KI216_RS12285	COG2814	Major facilitator Superfamily
KI216_RS12290	COG1289	transmembrane transporter activity
KI216_RS12300	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KI216_RS12360	COG2832	Protein of unknown function (DUF454)
KI216_RS12385	COG0643	Histidine kinase
KI216_RS12385	COG2198	Histidine kinase
KI216_RS12390	COG0840	transmembrane signaling receptor activity
KI216_RS12415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS12425	COG0442	prolyl-tRNA aminoacylation
KI216_RS12460	COG0489	protein tyrosine kinase activity
KI216_RS12485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KI216_RS12485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KI216_RS12500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KI216_RS12535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
KI216_RS12540	COG2081	HI0933 family
KI216_RS12555	COG0668	transmembrane transport
KI216_RS12565	COG4302	ethanolamine ammonia-lyase activity
KI216_RS12575	COG0531	amino acid
KI216_RS12590	COG0583	DNA-binding transcription factor activity
KI216_RS12595	COG1278	Cold shock
KI216_RS12615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KI216_RS12620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KI216_RS12625	COG0713	ATP synthesis coupled electron transport
KI216_RS12635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KI216_RS12650	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KI216_RS12680	COG2205	protein histidine kinase activity
KI216_RS12685	COG0745	RESPONSE REGULATOR receiver
KI216_RS12695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KI216_RS12700	COG5290	Psort location Cytoplasmic, score
KI216_RS12740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KI216_RS12740	COG0352	thiamine-phosphate diphosphorylase activity
KI216_RS12740	COG0351	phosphomethylpyrimidine kinase
KI216_RS12745	COG5342	invasion associated locus B
KI216_RS12750	COG0494	nUDIX hydrolase
KI216_RS12770	COG3422	double-strand break repair
KI216_RS12780	COG2824	Alkylphosphonate utilization operon protein PhnA
KI216_RS12785	COG3189	MarR family transcriptional regulator
KI216_RS12810	COG0564	pseudouridine synthase activity
KI216_RS12865	COG0354	folic acid binding
KI216_RS12870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KI216_RS12900	COG1902	pentaerythritol trinitrate reductase activity
KI216_RS12905	COG4772	TonB-dependent receptor
KI216_RS12920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KI216_RS12935	COG1217	gtp-binding protein TYPA
KI216_RS12940	COG2233	PERMEase
KI216_RS12950	COG0833	amino acid
KI216_RS12960	COG4969	Belongs to the N-Me-Phe pilin family
KI216_RS12965	COG0183	Belongs to the thiolase family
KI216_RS12990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KI216_RS13005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KI216_RS13010	COG2207	Transcriptional regulator
KI216_RS13020	COG0183	Belongs to the thiolase family
KI216_RS13025	COG1250	3-hydroxyacyl-CoA dehydrogenase
KI216_RS13025	COG1024	Enoyl-CoA hydratase
KI216_RS13030	COG1522	sequence-specific DNA binding
KI216_RS13060	COG1272	protein, Hemolysin III
KI216_RS13065	COG0477	Major facilitator Superfamily
KI216_RS13075	COG1408	metallophosphoesterase
KI216_RS13080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KI216_RS13090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KI216_RS13120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KI216_RS13125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KI216_RS13130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KI216_RS13135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KI216_RS13140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KI216_RS13145	COG0625	glutathione transferase activity
KI216_RS13150	COG2969	positive regulation of protein catabolic process
KI216_RS13205	COG2853	Lipoprotein
KI216_RS13220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KI216_RS13230	COG1764	response to oxidative stress
KI216_RS13280	COG0037	tRNA processing
KI216_RS13290	COG0248	Ppx GppA phosphatase
KI216_RS13315	COG0072	phenylalanine-tRNA ligase activity
KI216_RS13350	COG3210	domain, Protein
KI216_RS13380	COG1238	metal cluster binding
KI216_RS13395	COG0625	glutathione transferase activity
KI216_RS13410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KI216_RS13420	COG0318	PFAM AMP-dependent synthetase and ligase
KI216_RS13430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KI216_RS13435	COG1660	Displays ATPase and GTPase activities
KI216_RS13450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KI216_RS13455	COG0617	tRNA 3'-terminal CCA addition
KI216_RS13460	COG1555	photosystem II stabilization
KI216_RS13465	COG3956	TIGRFAM MazG family protein
KI216_RS13470	COG0300	oxidoreductase activity
KI216_RS13480	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KI216_RS13565	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KI216_RS13570	COG0440	acetolactate synthase activity
KI216_RS13575	COG0028	Belongs to the TPP enzyme family
KI216_RS13600	COG2703	oxygen carrier activity
KI216_RS13605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KI216_RS13610	COG0577	efflux transmembrane transporter activity
KI216_RS13610	COG1136	(ABC) transporter
KI216_RS13615	COG1538	Outer membrane efflux protein
KI216_RS13625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KI216_RS13630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
KI216_RS13635	COG1162	GTPase activity
KI216_RS13660	COG0084	hydrolase, TatD family'
KI216_RS13675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
KI216_RS13695	COG0793	Belongs to the peptidase S41A family
KI216_RS13710	COG2267	carboxylic ester hydrolase activity
KI216_RS13720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KI216_RS13725	COG0857	belongs to the CobB CobQ family
KI216_RS13725	COG0280	phosphate acetyltransferase
KI216_RS13745	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
KI216_RS13745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
KI216_RS13765	COG0740	serine-type endopeptidase activity
KI216_RS13775	COG4774	siderophore transport
KI216_RS13780	COG4774	siderophore transport
KI216_RS13785	COG3128	pkhd-type hydroxylase
KI216_RS13795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KI216_RS13805	COG2813	Specifically methylates the guanine in position
KI216_RS13805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KI216_RS13920	COG0788	formyltetrahydrofolate deformylase activity
KI216_RS13945	COG4651	solute:proton antiporter activity
KI216_RS13945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KI216_RS13970	COG0724	RNA recognition motif
KI216_RS13975	COG0210	DNA helicase
KI216_RS13980	COG1929	Belongs to the glycerate kinase type-1 family
KI216_RS14020	COG2900	Belongs to the SlyX family
KI216_RS14025	COG0488	(ABC) transporter
KI216_RS14030	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS14035	COG1560	Kdo2-lipid A biosynthetic process
KI216_RS14075	COG0252	asparaginase activity
KI216_RS14105	COG0473	3-isopropylmalate dehydrogenase activity
KI216_RS14120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KI216_RS14140	COG0583	DNA-binding transcription factor activity
KI216_RS14160	COG0494	nUDIX hydrolase
KI216_RS14185	COG0583	DNA-binding transcription factor activity
KI216_RS14190	COG1960	acyl-CoA dehydrogenase activity
KI216_RS14205	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
KI216_RS14240	COG0446	pyridine nucleotide-disulphide oxidoreductase
KI216_RS14245	COG3384	dioxygenase
KI216_RS14250	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS14265	COG4638	Rieske (2fe-2S)
KI216_RS14270	COG0583	DNA-binding transcription factor activity
KI216_RS14295	COG4569	acetaldehyde dehydrogenase (acetylating) activity
KI216_RS14300	COG3971	2-oxopent-4-enoate hydratase activity
KI216_RS14305	COG0546	phosphoglycolate phosphatase activity
KI216_RS14315	COG1530	ribonuclease E activity
KI216_RS14320	COG0318	PFAM AMP-dependent synthetase and ligase
KI216_RS14350	COG1983	PspC domain protein
KI216_RS14355	COG0517	IMP dehydrogenase activity
KI216_RS14365	COG0752	glycyl-tRNA synthetase alpha subunit
KI216_RS14370	COG0751	glycine-tRNA ligase activity
KI216_RS14395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KI216_RS14425	COG0493	'glutamate synthase
KI216_RS14435	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
KI216_RS14440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KI216_RS14455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KI216_RS14465	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
KI216_RS14465	COG0644	oxidoreductase
KI216_RS14470	COG0425	Belongs to the sulfur carrier protein TusA family
KI216_RS14475	COG4535	Mg2 and Co2 transporter CorC
KI216_RS14480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KI216_RS14485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KI216_RS14505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KI216_RS14515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KI216_RS14535	COG0484	heat shock protein binding
KI216_RS14540	COG0789	Transcriptional regulator
KI216_RS14545	COG2841	Protein conserved in bacteria
KI216_RS14550	COG0598	Magnesium transport protein CorA
KI216_RS14555	COG1185	polyribonucleotide nucleotidyltransferase activity
KI216_RS14565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KI216_RS14570	COG1074	ATP-dependent DNA helicase activity
KI216_RS14575	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
KI216_RS14605	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
KI216_RS14645	COG0427	acetyl-CoA hydrolase
KI216_RS14655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KI216_RS14690	COG0326	Molecular chaperone. Has ATPase activity
KI216_RS14705	COG2056	Na+-H+ antiporter family
KI216_RS14730	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KI216_RS14735	COG0085	RNA polymerase activity
KI216_RS14740	COG0222	ribosome binding
KI216_RS14745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KI216_RS14750	COG0081	regulation of translation
KI216_RS14765	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KI216_RS14805	COG0546	phosphoglycolate phosphatase activity
KI216_RS14855	COG0181	hydroxymethylbilane synthase activity
KI216_RS14865	COG3275	phosphorelay sensor kinase activity
KI216_RS14880	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KI216_RS14975	COG0131	Imidazoleglycerol-phosphate dehydratase
KI216_RS14980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KI216_RS15010	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KI216_RS15010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KI216_RS15015	COG0531	amino acid
KI216_RS15030	COG1278	Cold shock
KI216_RS15035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KI216_RS15085	COG3158	transport of potassium into the cell
KI216_RS15145	COG1335	isochorismatase
KI216_RS15150	COG0583	DNA-binding transcription factor activity
KI216_RS15175	COG0629	single-stranded DNA binding
KI216_RS15180	COG2814	Major facilitator Superfamily
KI216_RS15205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KI216_RS15215	COG3706	GGDEF domain
KI216_RS15230	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KI216_RS15235	COG3162	membrane
KI216_RS15240	COG0784	Response regulator, receiver
KI216_RS15240	COG2205	protein histidine kinase activity
KI216_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS15280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KI216_RS15290	COG0668	transmembrane transport
KI216_RS15295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KI216_RS15300	COG1519	Transferase
KI216_RS15305	COG1902	pentaerythritol trinitrate reductase activity
KI216_RS15330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KI216_RS15355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KI216_RS15355	COG0426	domain, Protein
KI216_RS15360	COG2119	membrane
KI216_RS15390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KI216_RS15400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KI216_RS15405	COG1181	Belongs to the D-alanine--D-alanine ligase family
KI216_RS15410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KI216_RS15420	COG0189	ligase activity
KI216_RS15435	COG0753	catalase activity
KI216_RS15465	COG0708	Exodeoxyribonuclease III
KI216_RS15470	COG1393	Belongs to the ArsC family
KI216_RS15485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KI216_RS15490	COG3706	GGDEF domain
KI216_RS15495	COG0625	glutathione transferase activity
KI216_RS15525	COG1247	-acetyltransferase
KI216_RS15550	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KI216_RS15555	COG2918	glutathione biosynthetic process
KI216_RS15570	COG2733	membrane
KI216_RS15615	COG0753	catalase activity
KI216_RS15635	COG0560	Phosphoserine phosphatase
KI216_RS15635	COG3830	Belongs to the UPF0237 family
KI216_RS15650	COG0385	Bile acid
KI216_RS15655	COG1335	isochorismatase
KI216_RS15660	COG2814	Major facilitator Superfamily
KI216_RS15665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KI216_RS15680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KI216_RS15685	COG3300	MHYT domain
KI216_RS15685	COG5001	Diguanylate cyclase
KI216_RS15690	COG1683	Conserved Protein
KI216_RS15695	COG2983	Belongs to the UPF0260 family
KI216_RS15700	COG5487	UPF0391 membrane protein
KI216_RS15710	COG3023	N-Acetylmuramoyl-L-alanine amidase
KI216_RS15725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KI216_RS15730	COG1309	transcriptional regulator
KI216_RS15735	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KI216_RS15740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KI216_RS15745	COG0546	phosphoglycolate phosphatase activity
KI216_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
KI216_RS15770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KI216_RS15770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KI216_RS15775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KI216_RS15780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KI216_RS15785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KI216_RS15790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KI216_RS15795	COG1116	anion transmembrane transporter activity
KI216_RS15800	COG1309	transcriptional regulator
KI216_RS15820	COG0196	riboflavin kinase activity
KI216_RS15825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KI216_RS15835	COG1047	Peptidyl-prolyl cis-trans
KI216_RS15840	COG0431	NADPH-dependent FMN reductase
KI216_RS15865	COG2814	Major facilitator Superfamily
KI216_RS15905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KI216_RS15910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
KI216_RS15915	COG2951	lytic endotransglycosylase activity
KI216_RS15920	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KI216_RS15935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KI216_RS15950	COG2388	GCN5-related N-acetyl-transferase
KI216_RS15955	COG2814	Major facilitator Superfamily
KI216_RS15960	COG0861	Integral membrane protein TerC family
KI216_RS15970	COG0402	S-adenosylhomocysteine deaminase activity
KI216_RS15990	COG1230	cation diffusion facilitator family transporter
KI216_RS16010	COG0706	membrane insertase activity
KI216_RS16015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane