locus-tag	class	description
BUM88_RS00015	COG1047	Peptidyl-prolyl cis-trans
BUM88_RS00025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BUM88_RS00030	COG0196	riboflavin kinase activity
BUM88_RS00040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BUM88_RS00045	COG1309	transcriptional regulator
BUM88_RS00050	COG1116	anion transmembrane transporter activity
BUM88_RS00055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS00060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS00065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BUM88_RS00070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BUM88_RS00075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BUM88_RS00075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BUM88_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS00095	COG0546	phosphoglycolate phosphatase activity
BUM88_RS00155	COG3023	N-Acetylmuramoyl-L-alanine amidase
BUM88_RS00160	COG0728	peptidoglycan biosynthetic process
BUM88_RS00190	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BUM88_RS00195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BUM88_RS00200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BUM88_RS00240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BUM88_RS00250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BUM88_RS00260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BUM88_RS00275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BUM88_RS00280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BUM88_RS00290	COG2186	Transcriptional regulator
BUM88_RS00300	COG0277	FAD linked oxidase domain protein
BUM88_RS00305	COG1448	Aminotransferase
BUM88_RS00310	COG1802	Transcriptional regulator
BUM88_RS00325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BUM88_RS00360	COG1051	belongs to the nudix hydrolase family
BUM88_RS00425	COG0564	pseudouridine synthase activity
BUM88_RS00465	COG0251	oxidation-reduction process
BUM88_RS00470	COG1113	amino acid transport
BUM88_RS00475	COG1113	amino acid transport
BUM88_RS00495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BUM88_RS00500	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS00505	COG1024	Enoyl-CoA hydratase
BUM88_RS00510	COG1024	Enoyl-CoA hydratase
BUM88_RS00515	COG0477	Major facilitator Superfamily
BUM88_RS00520	COG3916	Acyl-homoserine-lactone synthase
BUM88_RS00530	COG2197	response regulator
BUM88_RS00540	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS00545	COG0300	oxidoreductase activity
BUM88_RS00545	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS00545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS00545	COG3321	synthase
BUM88_RS00550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS00580	COG0271	Belongs to the BolA IbaG family
BUM88_RS00590	COG1192	Involved in chromosome partitioning
BUM88_RS00605	COG0586	Pfam SNARE associated Golgi protein
BUM88_RS00610	COG2259	Doxx family
BUM88_RS00615	COG4399	Belongs to the UPF0754 family
BUM88_RS00620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BUM88_RS00620	COG0519	Catalyzes the synthesis of GMP from XMP
BUM88_RS00665	COG0281	malic enzyme
BUM88_RS00670	COG2837	iron assimilation
BUM88_RS00675	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS00680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BUM88_RS00685	COG1121	(ABC) transporter
BUM88_RS00730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BUM88_RS00735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BUM88_RS00740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BUM88_RS00755	COG0386	Belongs to the glutathione peroxidase family
BUM88_RS00770	COG1309	transcriptional regulator
BUM88_RS00775	COG0697	spore germination
BUM88_RS00785	COG0758	DNA mediated transformation
BUM88_RS00820	COG1309	transcriptional regulator
BUM88_RS00855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BUM88_RS00880	COG0789	Transcriptional regulator
BUM88_RS00910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BUM88_RS00920	COG2814	Major facilitator Superfamily
BUM88_RS00930	COG1253	flavin adenine dinucleotide binding
BUM88_RS00935	COG3012	SEC-C Motif Domain Protein
BUM88_RS00940	COG2860	membrane
BUM88_RS00945	COG0477	Major facilitator Superfamily
BUM88_RS00955	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS00970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BUM88_RS00995	COG0431	NADPH-dependent FMN reductase
BUM88_RS01000	COG0606	chelatase, subunit chli
BUM88_RS01010	COG0347	Belongs to the P(II) protein family
BUM88_RS01015	COG0004	ammonium transporteR
BUM88_RS01025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BUM88_RS01025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BUM88_RS01065	COG0795	lipopolysaccharide-transporting ATPase activity
BUM88_RS01070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BUM88_RS01075	COG0793	Belongs to the peptidase S41A family
BUM88_RS01090	COG2197	response regulator
BUM88_RS01100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BUM88_RS01110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BUM88_RS01115	COG4974	Belongs to the 'phage' integrase family
BUM88_RS01140	COG0772	Belongs to the SEDS family
BUM88_RS01145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BUM88_RS01150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BUM88_RS01155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BUM88_RS01190	COG1538	Outer membrane efflux protein
BUM88_RS01210	COG3275	phosphorelay sensor kinase activity
BUM88_RS01220	COG0181	hydroxymethylbilane synthase activity
BUM88_RS01265	COG1716	ATPase activity
BUM88_RS01270	COG0546	phosphoglycolate phosphatase activity
BUM88_RS01300	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BUM88_RS01330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BUM88_RS01335	COG0222	ribosome binding
BUM88_RS01375	COG2056	Na+-H+ antiporter family
BUM88_RS01390	COG0326	Molecular chaperone. Has ATPase activity
BUM88_RS01405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BUM88_RS01485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BUM88_RS01490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BUM88_RS01490	COG2169	Transcriptional regulator
BUM88_RS01525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BUM88_RS01535	COG0497	DNA recombination
BUM88_RS01550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BUM88_RS01560	COG0237	dephospho-CoA kinase activity
BUM88_RS01610	COG0195	Participates in both transcription termination and antitermination
BUM88_RS01620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BUM88_RS01625	COG1320	monovalent cation:proton antiporter activity
BUM88_RS01630	COG2212	antiporter activity
BUM88_RS01635	COG1863	multisubunit Na H antiporter MnhE subunit
BUM88_RS01640	COG0651	ATP synthesis coupled electron transport
BUM88_RS01645	COG1006	Multisubunit Na H antiporter MnhC subunit
BUM88_RS01650	COG2111	Na H antiporter
BUM88_RS01650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BUM88_RS01665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BUM88_RS01695	COG2226	methyltransferase
BUM88_RS01715	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BUM88_RS01720	COG1074	ATP-dependent DNA helicase activity
BUM88_RS01725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BUM88_RS01730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BUM88_RS01740	COG1185	polyribonucleotide nucleotidyltransferase activity
BUM88_RS01745	COG0598	Magnesium transport protein CorA
BUM88_RS01750	COG0789	Transcriptional regulator
BUM88_RS01755	COG0484	heat shock protein binding
BUM88_RS01765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BUM88_RS01775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BUM88_RS01800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUM88_RS01805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BUM88_RS01810	COG4535	Mg2 and Co2 transporter CorC
BUM88_RS01825	COG0644	oxidoreductase
BUM88_RS01825	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BUM88_RS01835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BUM88_RS01850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BUM88_RS01855	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BUM88_RS01865	COG0493	'glutamate synthase
BUM88_RS01895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BUM88_RS01910	COG0534	Mate efflux family protein
BUM88_RS01920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BUM88_RS01925	COG4221	oxidoreductase activity
BUM88_RS01930	COG0583	DNA-binding transcription factor activity
BUM88_RS01945	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS01950	COG1530	ribonuclease E activity
BUM88_RS01970	COG2378	regulation of single-species biofilm formation
BUM88_RS01975	COG0625	glutathione transferase activity
BUM88_RS01985	COG0583	DNA-binding transcription factor activity
BUM88_RS02030	COG0583	DNA-binding transcription factor activity
BUM88_RS02055	COG0473	3-isopropylmalate dehydrogenase activity
BUM88_RS02110	COG1301	dicarboxylic acid transport
BUM88_RS02120	COG1560	Kdo2-lipid A biosynthetic process
BUM88_RS02130	COG0488	(ABC) transporter
BUM88_RS02135	COG2900	Belongs to the SlyX family
BUM88_RS02140	COG0604	alcohol dehydrogenase
BUM88_RS02145	COG1733	regulation of RNA biosynthetic process
BUM88_RS02170	COG0210	DNA helicase
BUM88_RS02175	COG0724	RNA recognition motif
BUM88_RS02195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BUM88_RS02195	COG4651	solute:proton antiporter activity
BUM88_RS02220	COG0788	formyltetrahydrofolate deformylase activity
BUM88_RS02320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BUM88_RS02320	COG2813	Specifically methylates the guanine in position
BUM88_RS02330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BUM88_RS02340	COG4774	siderophore transport
BUM88_RS02350	COG0740	serine-type endopeptidase activity
BUM88_RS02370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BUM88_RS02370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BUM88_RS02375	COG0857	belongs to the CobB CobQ family
BUM88_RS02375	COG0280	phosphate acetyltransferase
BUM88_RS02380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BUM88_RS02395	COG0800	Aldolase
BUM88_RS02405	COG3265	gluconokinase activity
BUM88_RS02410	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS02420	COG2267	carboxylic ester hydrolase activity
BUM88_RS02435	COG0793	Belongs to the peptidase S41A family
BUM88_RS02450	COG2975	iron-sulfur cluster assembly
BUM88_RS02470	COG1426	Protein conserved in bacteria
BUM88_RS02490	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BUM88_RS02515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BUM88_RS02525	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS02530	COG1216	Glycosyl transferase, family 2
BUM88_RS02580	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS02585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BUM88_RS02605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BUM88_RS02615	COG1162	GTPase activity
BUM88_RS02620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BUM88_RS02640	COG1136	(ABC) transporter
BUM88_RS02640	COG0577	efflux transmembrane transporter activity
BUM88_RS02645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS02665	COG0028	Belongs to the TPP enzyme family
BUM88_RS02670	COG0440	acetolactate synthase activity
BUM88_RS02675	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BUM88_RS02705	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BUM88_RS02720	COG0084	hydrolase, TatD family'
BUM88_RS02730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BUM88_RS02740	COG0583	DNA-binding transcription factor activity
BUM88_RS02755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BUM88_RS02760	COG2814	Major facilitator Superfamily
BUM88_RS02770	COG0697	spore germination
BUM88_RS02805	COG3622	Belongs to the hyi family
BUM88_RS02810	COG2084	Dehydrogenase
BUM88_RS02815	COG1024	Enoyl-CoA hydratase
BUM88_RS02820	COG2205	protein histidine kinase activity
BUM88_RS02820	COG5002	protein histidine kinase activity
BUM88_RS02820	COG0784	Response regulator, receiver
BUM88_RS02825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BUM88_RS02840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BUM88_RS02850	COG3956	TIGRFAM MazG family protein
BUM88_RS02855	COG1555	photosystem II stabilization
BUM88_RS02860	COG0617	tRNA 3'-terminal CCA addition
BUM88_RS02865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BUM88_RS02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BUM88_RS02890	COG3028	Belongs to the UPF0307 family
BUM88_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS02905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BUM88_RS02915	COG0625	glutathione transferase activity
BUM88_RS02920	COG1238	metal cluster binding
BUM88_RS02930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BUM88_RS02960	COG0072	phenylalanine-tRNA ligase activity
BUM88_RS02990	COG0248	Ppx GppA phosphatase
BUM88_RS03000	COG0037	tRNA processing
BUM88_RS03040	COG1764	response to oxidative stress
BUM88_RS03045	COG1846	Transcriptional regulator
BUM88_RS03055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BUM88_RS03115	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BUM88_RS03120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BUM88_RS03125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BUM88_RS03175	COG0494	nUDIX hydrolase
BUM88_RS03185	COG1214	PFAM Peptidase M22, glycoprotease
BUM88_RS03200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BUM88_RS03210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BUM88_RS03215	COG0561	phosphatase activity
BUM88_RS03225	COG2132	Multicopper oxidase
BUM88_RS03245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BUM88_RS03250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BUM88_RS03255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BUM88_RS03285	COG1063	alcohol dehydrogenase
BUM88_RS03290	COG0583	DNA-binding transcription factor activity
BUM88_RS03295	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS03300	COG2814	Major facilitator Superfamily
BUM88_RS03305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BUM88_RS03310	COG1309	transcriptional regulator
BUM88_RS03325	COG1053	succinate dehydrogenase
BUM88_RS03330	COG0583	DNA-binding transcription factor activity
BUM88_RS03350	COG0583	DNA-binding transcription factor activity
BUM88_RS03365	COG1473	amidohydrolase
BUM88_RS03385	COG0583	DNA-binding transcription factor activity
BUM88_RS03400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS03445	COG3403	YqcI/YcgG family
BUM88_RS03450	COG0583	DNA-binding transcription factor activity
BUM88_RS03470	COG0384	phenazine biosynthesis protein PhzF
BUM88_RS03480	COG0251	oxidation-reduction process
BUM88_RS03495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BUM88_RS03500	COG3781	membrane
BUM88_RS03505	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BUM88_RS03525	COG0745	RESPONSE REGULATOR receiver
BUM88_RS03540	COG2199	diguanylate cyclase activity
BUM88_RS03565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BUM88_RS03580	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BUM88_RS03595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BUM88_RS03600	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BUM88_RS03620	COG0583	DNA-binding transcription factor activity
BUM88_RS03625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BUM88_RS03640	COG0668	transmembrane transport
BUM88_RS03650	COG2081	HI0933 family
BUM88_RS03655	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BUM88_RS03690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUM88_RS03690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BUM88_RS03700	COG0489	protein tyrosine kinase activity
BUM88_RS03765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BUM88_RS03780	COG0730	response to heat
BUM88_RS03790	COG1196	nuclear chromosome segregation
BUM88_RS03810	COG2223	nitrite transmembrane transporter activity
BUM88_RS03815	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BUM88_RS03825	COG0596	Alpha beta hydrolase
BUM88_RS03825	COG2226	methyltransferase
BUM88_RS03825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BUM88_RS03840	COG4106	trans-aconitate 2-methyltransferase activity
BUM88_RS03855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BUM88_RS03860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BUM88_RS03865	COG0009	L-threonylcarbamoyladenylate synthase
BUM88_RS03870	COG3101	peptidyl-lysine hydroxylation
BUM88_RS03875	COG1399	metal-binding, possibly nucleic acid-binding protein
BUM88_RS03890	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS03900	COG1652	LysM domain
BUM88_RS03905	COG0352	thiamine-phosphate diphosphorylase activity
BUM88_RS03905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BUM88_RS03905	COG0351	phosphomethylpyrimidine kinase
BUM88_RS03915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BUM88_RS03945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BUM88_RS03970	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BUM88_RS03985	COG0358	DNA primase activity
BUM88_RS04020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BUM88_RS04050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BUM88_RS04050	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BUM88_RS04060	COG1981	membrane
BUM88_RS04075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BUM88_RS04080	COG0049	tRNA binding
BUM88_RS04085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BUM88_RS04090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BUM88_RS04105	COG0456	acetyltransferase
BUM88_RS04115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BUM88_RS04125	COG0492	ferredoxin-NADP+ reductase activity
BUM88_RS04130	COG1674	ftsk spoiiie
BUM88_RS04135	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS04170	COG0204	Acyl-transferase
BUM88_RS04175	COG2885	chlorophyll binding
BUM88_RS04180	COG0210	DNA helicase
BUM88_RS04190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BUM88_RS04205	COG0121	glutamine amidotransferase
BUM88_RS04225	COG2914	Belongs to the UPF0125 (RnfH) family
BUM88_RS04230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BUM88_RS04235	COG0735	belongs to the Fur family
BUM88_RS04260	COG0420	3'-5' exonuclease activity
BUM88_RS04280	COG1090	epimerase
BUM88_RS04295	COG2050	protein possibly involved in aromatic compounds catabolism
BUM88_RS04300	COG1566	PFAM secretion protein HlyD family protein
BUM88_RS04305	COG2814	Major facilitator Superfamily
BUM88_RS04310	COG0405	Gamma-glutamyltransferase
BUM88_RS04355	COG0477	Major facilitator Superfamily
BUM88_RS04360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BUM88_RS04370	COG1595	DNA-templated transcription, initiation
BUM88_RS04425	COG0531	amino acid
BUM88_RS04430	COG2040	homocysteine
BUM88_RS04455	COG1309	transcriptional regulator
BUM88_RS04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BUM88_RS04465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BUM88_RS04475	COG1607	acyl-coa hydrolase
BUM88_RS04485	COG0523	cobalamin synthesis protein
BUM88_RS04495	COG4681	YaeQ
BUM88_RS04505	COG1649	PFAM Uncharacterised BCR, COG1649
BUM88_RS04505	COG0726	polysaccharide deacetylase
BUM88_RS04510	COG1215	transferase activity, transferring glycosyl groups
BUM88_RS04520	COG1309	transcriptional regulator
BUM88_RS04530	COG1024	Enoyl-CoA hydratase
BUM88_RS04550	COG1414	Transcriptional regulator
BUM88_RS04585	COG2271	Major facilitator Superfamily
BUM88_RS04595	COG2267	carboxylic ester hydrolase activity
BUM88_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS04615	COG0028	Belongs to the TPP enzyme family
BUM88_RS04625	COG0477	Major facilitator Superfamily
BUM88_RS04630	COG0242	peptide deformylase activity
BUM88_RS04635	COG2066	Belongs to the glutaminase family
BUM88_RS04640	COG2207	Transcriptional regulator
BUM88_RS04640	COG0662	Cupin 2, conserved barrel domain protein
BUM88_RS04645	COG2223	nitrite transmembrane transporter activity
BUM88_RS04665	COG0583	DNA-binding transcription factor activity
BUM88_RS04670	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS04675	COG2271	Major facilitator Superfamily
BUM88_RS04680	COG3959	Transketolase, thiamine diphosphate binding domain
BUM88_RS04685	COG3958	Transketolase
BUM88_RS04695	COG0306	phosphate transporter
BUM88_RS04715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BUM88_RS04760	COG4181	ATPase activity
BUM88_RS04765	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BUM88_RS04795	COG0583	DNA-binding transcription factor activity
BUM88_RS04805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BUM88_RS04810	COG1773	rubredoxin
BUM88_RS04860	COG2851	Citrate transporter
BUM88_RS04865	COG1253	flavin adenine dinucleotide binding
BUM88_RS04880	COG3015	lipoprotein NlpE involved in copper resistance
BUM88_RS04905	COG0804	urea catabolic process
BUM88_RS04915	COG0830	nickel cation binding
BUM88_RS04930	COG0742	ribosomal rna small subunit methyltransferase
BUM88_RS04935	COG0768	penicillin binding
BUM88_RS04960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BUM88_RS04965	COG2878	Part of a membrane complex involved in electron transport
BUM88_RS04970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BUM88_RS04980	COG3384	dioxygenase
BUM88_RS04995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BUM88_RS05035	COG0006	proline dipeptidase activity
BUM88_RS05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BUM88_RS05045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BUM88_RS05055	COG0789	Transcriptional regulator
BUM88_RS05070	COG0583	DNA-binding transcription factor activity
BUM88_RS05115	COG1388	LysM domain
BUM88_RS05115	COG1388	LysM domain
BUM88_RS05115	COG0741	lytic transglycosylase activity
BUM88_RS05115	COG0741	lytic transglycosylase activity
BUM88_RS05120	COG4166	transmembrane transport
BUM88_RS05125	COG4174	ABC transporter (Permease)
BUM88_RS05130	COG4239	(ABC) transporter, permease
BUM88_RS05135	COG4172	Belongs to the ABC transporter superfamily
BUM88_RS05155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BUM88_RS05165	COG3706	GGDEF domain
BUM88_RS05165	COG4251	negative regulation of phosphorylation
BUM88_RS05165	COG5001	Diguanylate cyclase
BUM88_RS05165	COG2203	Gaf domain
BUM88_RS05180	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS05180	COG0446	pyridine nucleotide-disulphide oxidoreductase
BUM88_RS05205	COG4269	membrane
BUM88_RS05245	COG1113	amino acid transport
BUM88_RS05260	COG0531	amino acid
BUM88_RS05280	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS05305	COG1113	amino acid transport
BUM88_RS05340	COG0697	spore germination
BUM88_RS05345	COG2721	sulfolactate sulfo-lyase activity
BUM88_RS05350	COG2271	Major facilitator Superfamily
BUM88_RS05355	COG4948	Mandelate Racemase Muconate Lactonizing
BUM88_RS05365	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS05370	COG2186	Transcriptional regulator
BUM88_RS05395	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS05405	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS05410	COG1024	Enoyl-CoA hydratase
BUM88_RS05415	COG2814	Major facilitator Superfamily
BUM88_RS05430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BUM88_RS05445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BUM88_RS05465	COG1944	ATP diphosphatase activity
BUM88_RS05495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BUM88_RS05510	COG0583	DNA-binding transcription factor activity
BUM88_RS05515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
BUM88_RS05520	COG2072	flavoprotein involved in K transport
BUM88_RS05525	COG0300	oxidoreductase activity
BUM88_RS05535	COG1309	transcriptional regulator
BUM88_RS05540	COG1741	Belongs to the pirin family
BUM88_RS05550	COG2252	PERMEase
BUM88_RS05555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BUM88_RS05560	COG3038	cytochrome b561
BUM88_RS05570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BUM88_RS05580	COG0527	aspartate kinase activity
BUM88_RS05590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BUM88_RS05605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BUM88_RS05620	COG0667	Aldo Keto reductase
BUM88_RS05630	COG1765	OsmC-like protein
BUM88_RS05645	COG0542	response to heat
BUM88_RS05680	COG2885	chlorophyll binding
BUM88_RS05690	COG0625	glutathione transferase activity
BUM88_RS05700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BUM88_RS05720	COG3634	alkyl hydroperoxide reductase activity
BUM88_RS05730	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BUM88_RS05740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BUM88_RS05755	COG1643	Atp-dependent helicase
BUM88_RS05770	COG2814	Major facilitator Superfamily
BUM88_RS05775	COG3135	benzoate transporter
BUM88_RS05780	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS05785	COG0543	2 iron, 2 sulfur cluster binding
BUM88_RS05785	COG0633	Ferredoxin
BUM88_RS05795	COG4638	Rieske (2fe-2S)
BUM88_RS05805	COG0583	DNA-binding transcription factor activity
BUM88_RS05855	COG1570	exodeoxyribonuclease VII activity
BUM88_RS05890	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS05895	COG1560	Kdo2-lipid A biosynthetic process
BUM88_RS05900	COG1278	Cold shock
BUM88_RS05925	COG1011	Hydrolase
BUM88_RS05930	COG2226	methyltransferase
BUM88_RS06000	COG0668	transmembrane transport
BUM88_RS06030	COG2814	Major facilitator Superfamily
BUM88_RS06085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BUM88_RS06095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BUM88_RS06100	COG1137	ATPase activity
BUM88_RS06105	COG1538	Outer membrane efflux protein
BUM88_RS06135	COG4122	O-methyltransferase activity
BUM88_RS06150	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BUM88_RS06175	COG2030	dehydratase
BUM88_RS06175	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS06180	COG3396	Phenylacetate-CoA oxygenase
BUM88_RS06185	COG3460	Phenylacetate-CoA oxygenase
BUM88_RS06190	COG3396	Phenylacetate-CoA oxygenase
BUM88_RS06195	COG2151	metal-sulfur cluster biosynthetic enzyme
BUM88_RS06200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BUM88_RS06205	COG1024	Enoyl-CoA hydratase
BUM88_RS06210	COG1024	Enoyl-CoA hydratase
BUM88_RS06215	COG1250	3-hydroxyacyl-CoA dehydrogenase
BUM88_RS06220	COG0183	Belongs to the thiolase family
BUM88_RS06225	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BUM88_RS06230	COG3327	negative regulation of DNA-templated transcription, initiation
BUM88_RS06240	COG2050	protein possibly involved in aromatic compounds catabolism
BUM88_RS06265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BUM88_RS06280	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BUM88_RS06285	COG0531	amino acid
BUM88_RS06355	COG0583	DNA-binding transcription factor activity
BUM88_RS06360	COG0402	S-adenosylhomocysteine deaminase activity
BUM88_RS06380	COG3712	iron ion homeostasis
BUM88_RS06395	COG2259	Doxx family
BUM88_RS06405	COG0657	acetylesterase activity
BUM88_RS06420	COG1309	transcriptional regulator
BUM88_RS06425	COG0583	DNA-binding transcription factor activity
BUM88_RS06435	COG2814	Major facilitator Superfamily
BUM88_RS06440	COG1051	belongs to the nudix hydrolase family
BUM88_RS06460	COG1309	transcriptional regulator
BUM88_RS06510	COG1914	H( )-stimulated, divalent metal cation uptake system
BUM88_RS06530	COG4770	biotin carboxylase activity
BUM88_RS06535	COG0038	chloride channel
BUM88_RS06605	COG1250	3-hydroxyacyl-CoA dehydrogenase
BUM88_RS06620	COG0439	Biotin carboxylase
BUM88_RS06625	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUM88_RS06630	COG1733	regulation of RNA biosynthetic process
BUM88_RS06640	COG0864	Transcriptional regulator
BUM88_RS06650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUM88_RS06655	COG1116	anion transmembrane transporter activity
BUM88_RS06670	COG0477	Major facilitator Superfamily
BUM88_RS06785	COG2885	chlorophyll binding
BUM88_RS06830	COG0666	response to abiotic stimulus
BUM88_RS06835	COG0590	tRNA wobble adenosine to inosine editing
BUM88_RS06840	COG2807	transmembrane transport
BUM88_RS06855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUM88_RS06860	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BUM88_RS06870	COG0789	Transcriptional regulator
BUM88_RS06885	COG1760	l-serine dehydratase
BUM88_RS06900	COG0406	alpha-ribazole phosphatase activity
BUM88_RS06930	COG1414	Transcriptional regulator
BUM88_RS06940	COG0753	catalase activity
BUM88_RS06945	COG3038	cytochrome b561
BUM88_RS06950	COG0154	amidase activity
BUM88_RS06975	COG2814	Major facilitator Superfamily
BUM88_RS06990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS06995	COG2814	Major facilitator Superfamily
BUM88_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS07015	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BUM88_RS07020	COG1414	Transcriptional regulator
BUM88_RS07025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BUM88_RS07030	COG2814	Major facilitator Superfamily
BUM88_RS07035	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS07040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BUM88_RS07050	COG1024	Enoyl-CoA hydratase
BUM88_RS07060	COG2814	Major facilitator Superfamily
BUM88_RS07070	COG0183	Belongs to the thiolase family
BUM88_RS07080	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS07085	COG1024	Enoyl-CoA hydratase
BUM88_RS07090	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS07095	COG2814	Major facilitator Superfamily
BUM88_RS07100	COG2814	Major facilitator Superfamily
BUM88_RS07105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BUM88_RS07110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BUM88_RS07120	COG2814	Major facilitator Superfamily
BUM88_RS07130	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS07145	COG0583	DNA-binding transcription factor activity
BUM88_RS07155	COG4770	biotin carboxylase activity
BUM88_RS07160	COG1024	Enoyl-CoA hydratase
BUM88_RS07165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BUM88_RS07170	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS07175	COG1309	transcriptional regulator
BUM88_RS07180	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS07195	COG2814	Major facilitator Superfamily
BUM88_RS07210	COG0583	DNA-binding transcription factor activity
BUM88_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS07275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BUM88_RS07295	COG0784	Response regulator, receiver
BUM88_RS07295	COG2205	protein histidine kinase activity
BUM88_RS07335	COG0765	amino acid transport
BUM88_RS07340	COG0765	amino acid transport
BUM88_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUM88_RS07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUM88_RS07370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BUM88_RS07375	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS07380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BUM88_RS07385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BUM88_RS07390	COG1045	serine acetyltransferase
BUM88_RS07415	COG0625	glutathione transferase activity
BUM88_RS07420	COG0625	glutathione transferase activity
BUM88_RS07425	COG0583	DNA-binding transcription factor activity
BUM88_RS07435	COG1346	cytolysis
BUM88_RS07455	COG1917	Cupin 2, conserved barrel domain protein
BUM88_RS07455	COG2207	Transcriptional regulator
BUM88_RS07460	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS07480	COG3052	prosthetic group binding
BUM88_RS07500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BUM88_RS07520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUM88_RS07530	COG1294	oxidase, subunit
BUM88_RS07535	COG1271	oxidase subunit
BUM88_RS07560	COG0477	Major facilitator Superfamily
BUM88_RS07570	COG4521	taurine ABC transporter
BUM88_RS07575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BUM88_RS07580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS07585	COG2175	clavaminate synthase activity
BUM88_RS07595	COG1953	Uracil, thiamine, allantoin
BUM88_RS07605	COG0583	DNA-binding transcription factor activity
BUM88_RS07615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BUM88_RS07630	COG0640	Transcriptional regulator
BUM88_RS07640	COG0798	PFAM Bile acid sodium symporter
BUM88_RS07645	COG0431	NADPH-dependent FMN reductase
BUM88_RS07650	COG0583	DNA-binding transcription factor activity
BUM88_RS07665	COG3634	alkyl hydroperoxide reductase activity
BUM88_RS07700	COG1301	dicarboxylic acid transport
BUM88_RS07705	COG0436	Aminotransferase
BUM88_RS07715	COG0386	Belongs to the glutathione peroxidase family
BUM88_RS07720	COG2207	Transcriptional regulator
BUM88_RS07720	COG1917	Cupin 2, conserved barrel domain protein
BUM88_RS07755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BUM88_RS07780	COG0012	GTP binding
BUM88_RS07785	COG2011	ABC-type metal ion transport system permease component
BUM88_RS07790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BUM88_RS07795	COG1464	Belongs to the NlpA lipoprotein family
BUM88_RS07800	COG1464	Belongs to the NlpA lipoprotein family
BUM88_RS07825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BUM88_RS07830	COG0765	amino acid transport
BUM88_RS07835	COG0765	amino acid transport
BUM88_RS07840	COG1126	abc transporter atp-binding protein
BUM88_RS07850	COG1522	sequence-specific DNA binding
BUM88_RS07865	COG1309	transcriptional regulator
BUM88_RS07875	COG0582	viral genome integration into host DNA
BUM88_RS08030	COG0270	DNA (cytosine-5-)-methyltransferase activity
BUM88_RS08055	COG5410	chromosome segregation
BUM88_RS08160	COG1598	PFAM Uncharacterised protein family UPF0150
BUM88_RS08170	COG1196	nuclear chromosome segregation
BUM88_RS08170	COG0741	lytic transglycosylase activity
BUM88_RS08170	COG0739	heme binding
BUM88_RS08250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BUM88_RS08270	COG0583	DNA-binding transcription factor activity
BUM88_RS08280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BUM88_RS08290	COG0697	spore germination
BUM88_RS08295	COG0583	DNA-binding transcription factor activity
BUM88_RS08335	COG3539	Fimbrial protein
BUM88_RS08360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BUM88_RS08360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BUM88_RS08405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BUM88_RS08415	COG2353	YceI-like domain
BUM88_RS08425	COG3698	Phosphodiester glycosidase
BUM88_RS08440	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BUM88_RS08445	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BUM88_RS08445	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BUM88_RS08445	COG0506	proline dehydrogenase activity
BUM88_RS08455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BUM88_RS08460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BUM88_RS08480	COG1132	(ABC) transporter
BUM88_RS08485	COG3122	Protein conserved in bacteria
BUM88_RS08490	COG3619	membrane
BUM88_RS08500	COG0640	Transcriptional regulator
BUM88_RS08510	COG2850	peptidyl-arginine hydroxylation
BUM88_RS08515	COG0424	maF-like protein
BUM88_RS08535	COG0191	fructose-bisphosphate aldolase activity
BUM88_RS08540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BUM88_RS08555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BUM88_RS08565	COG1192	Involved in chromosome partitioning
BUM88_RS08570	COG1475	DNA binding
BUM88_RS08575	COG0811	peptide transport
BUM88_RS08585	COG1132	(ABC) transporter
BUM88_RS08590	COG1663	tetraacyldisaccharide 4'-kinase activity
BUM88_RS08610	COG0084	hydrolase, TatD family'
BUM88_RS08675	COG0776	regulation of translation
BUM88_RS08690	COG2431	L-lysine efflux transmembrane transporter activity
BUM88_RS08705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BUM88_RS08710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BUM88_RS08750	COG4166	transmembrane transport
BUM88_RS08755	COG0339	signal peptide processing
BUM88_RS08760	COG0601	transmembrane transport
BUM88_RS08800	COG0702	epimerase
BUM88_RS08805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BUM88_RS08825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BUM88_RS08855	COG0316	Belongs to the HesB IscA family
BUM88_RS08860	COG0822	iron-sulfur transferase activity
BUM88_RS08885	COG0776	regulation of translation
BUM88_RS08890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BUM88_RS08895	COG2207	Transcriptional regulator
BUM88_RS08900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BUM88_RS08905	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS08910	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS08925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BUM88_RS08960	COG0406	alpha-ribazole phosphatase activity
BUM88_RS08975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BUM88_RS08980	COG0730	response to heat
BUM88_RS09000	COG4773	Receptor
BUM88_RS09005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BUM88_RS09065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BUM88_RS09075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BUM88_RS09080	COG0583	DNA-binding transcription factor activity
BUM88_RS09110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BUM88_RS09120	COG0133	tryptophan synthase activity
BUM88_RS09140	COG3706	GGDEF domain
BUM88_RS09155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BUM88_RS09160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BUM88_RS09165	COG0022	dehydrogenase e1 component
BUM88_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
BUM88_RS09175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BUM88_RS09185	COG1063	alcohol dehydrogenase
BUM88_RS09205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BUM88_RS09205	COG3453	Protein conserved in bacteria
BUM88_RS09215	COG0730	response to heat
BUM88_RS09230	COG2207	Transcriptional regulator
BUM88_RS09230	COG3708	Transcriptional regulator
BUM88_RS09240	COG2188	Transcriptional regulator
BUM88_RS09255	COG4521	taurine ABC transporter
BUM88_RS09260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS09280	COG0477	Major facilitator Superfamily
BUM88_RS09290	COG1027	Aspartate ammonia-lyase
BUM88_RS09305	COG0583	DNA-binding transcription factor activity
BUM88_RS09310	COG0583	DNA-binding transcription factor activity
BUM88_RS09315	COG0183	Belongs to the thiolase family
BUM88_RS09320	COG2031	fatty acid transporter
BUM88_RS09335	COG0583	DNA-binding transcription factor activity
BUM88_RS09400	COG2131	deaminase
BUM88_RS09410	COG2610	gluconate transmembrane transporter activity
BUM88_RS09415	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS09420	COG2207	Transcriptional regulator
BUM88_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS09450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS09465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BUM88_RS09465	COG0543	2 iron, 2 sulfur cluster binding
BUM88_RS09470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
BUM88_RS09475	COG4638	Rieske (2fe-2S)
BUM88_RS09485	COG0725	ABC transporter, periplasmic molybdate-binding protein
BUM88_RS09490	COG4149	molybdate abc transporter
BUM88_RS09495	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BUM88_RS09525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS09530	COG3251	PFAM MbtH domain protein
BUM88_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS09545	COG1169	isochorismate synthase
BUM88_RS09550	COG1021	2,3-dihydroxybenzoate-AMP ligase
BUM88_RS09555	COG3433	isochorismatase activity
BUM88_RS09555	COG1535	isochorismatase
BUM88_RS09560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BUM88_RS09565	COG4771	TonB-dependent receptor
BUM88_RS09620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BUM88_RS09625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS09630	COG0745	RESPONSE REGULATOR receiver
BUM88_RS09635	COG2205	protein histidine kinase activity
BUM88_RS09645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BUM88_RS09665	COG0753	catalase activity
BUM88_RS09675	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BUM88_RS09700	COG3539	Fimbrial protein
BUM88_RS09730	COG0601	transmembrane transport
BUM88_RS09735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BUM88_RS09755	COG1132	(ABC) transporter
BUM88_RS09760	COG1132	(ABC) transporter
BUM88_RS09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS09790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BUM88_RS09805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS09810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS09815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BUM88_RS09820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS09855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS09865	COG4628	conserved protein (DUF2132)
BUM88_RS09870	COG0583	DNA-binding transcription factor activity
BUM88_RS09880	COG0371	Dehydrogenase
BUM88_RS09885	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS09890	COG0477	Major facilitator Superfamily
BUM88_RS10020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BUM88_RS10025	COG0583	DNA-binding transcription factor activity
BUM88_RS10030	COG1301	dicarboxylic acid transport
BUM88_RS10040	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS10045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS10050	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS10055	COG0702	epimerase
BUM88_RS10060	COG4221	oxidoreductase activity
BUM88_RS10090	COG1120	ATPase activity
BUM88_RS10095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BUM88_RS10130	COG1064	alcohol dehydrogenase
BUM88_RS10145	COG2207	Transcriptional regulator
BUM88_RS10170	COG1566	PFAM secretion protein HlyD family protein
BUM88_RS10250	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS10260	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS10270	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS10295	COG0583	DNA-binding transcription factor activity
BUM88_RS10350	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BUM88_RS10355	COG1309	transcriptional regulator
BUM88_RS10370	COG0583	DNA-binding transcription factor activity
BUM88_RS10380	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS10390	COG4689	acetoacetate decarboxylase
BUM88_RS10405	COG2084	Dehydrogenase
BUM88_RS10415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BUM88_RS10425	COG0583	DNA-binding transcription factor activity
BUM88_RS10435	COG0129	dihydroxy-acid dehydratase activity
BUM88_RS10440	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS10445	COG0702	epimerase
BUM88_RS10450	COG1733	regulation of RNA biosynthetic process
BUM88_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
BUM88_RS10495	COG1024	Enoyl-CoA hydratase
BUM88_RS10495	COG1250	3-hydroxyacyl-CoA dehydrogenase
BUM88_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS10510	COG4221	oxidoreductase activity
BUM88_RS10510	COG3321	synthase
BUM88_RS10510	COG0604	alcohol dehydrogenase
BUM88_RS10510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS10540	COG1309	transcriptional regulator
BUM88_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS10595	COG2186	Transcriptional regulator
BUM88_RS10605	COG0583	DNA-binding transcription factor activity
BUM88_RS10610	COG4948	Mandelate Racemase Muconate Lactonizing
BUM88_RS10615	COG4829	muconolactone delta-isomerase
BUM88_RS10625	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BUM88_RS10630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BUM88_RS10635	COG0183	Belongs to the thiolase family
BUM88_RS10640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BUM88_RS10650	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS10660	COG3733	amine oxidase
BUM88_RS10670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS10710	COG0154	amidase activity
BUM88_RS10720	COG2814	Major facilitator Superfamily
BUM88_RS10745	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS10750	COG0583	DNA-binding transcription factor activity
BUM88_RS10755	COG1414	Transcriptional regulator
BUM88_RS10770	COG2391	methyltransferase activity
BUM88_RS10780	COG4993	Dehydrogenase
BUM88_RS10785	COG3659	wide pore channel activity
BUM88_RS10790	COG3420	alginic acid biosynthetic process
BUM88_RS10795	COG0710	3-dehydroquinate dehydratase activity
BUM88_RS10800	COG3485	protocatechuate 3,4-dioxygenase
BUM88_RS10805	COG3485	protocatechuate 3,4-dioxygenase
BUM88_RS10810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BUM88_RS10815	COG2271	Major facilitator Superfamily
BUM88_RS10820	COG0596	Alpha beta hydrolase
BUM88_RS10825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BUM88_RS10830	COG0183	Belongs to the thiolase family
BUM88_RS10835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BUM88_RS10840	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BUM88_RS10850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BUM88_RS10855	COG4773	Receptor
BUM88_RS10870	COG2323	membrane
BUM88_RS10875	COG0148	phosphopyruvate hydratase activity
BUM88_RS10915	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS10915	COG0446	pyridine nucleotide-disulphide oxidoreductase
BUM88_RS10930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BUM88_RS10940	COG0542	response to heat
BUM88_RS10945	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BUM88_RS10975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BUM88_RS10980	COG0569	domain protein
BUM88_RS10985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BUM88_RS11000	COG4774	siderophore transport
BUM88_RS11005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BUM88_RS11015	COG1585	Membrane protein implicated in regulation of membrane protease activity
BUM88_RS11030	COG1294	oxidase, subunit
BUM88_RS11035	COG4890	Cyd operon protein YbgT
BUM88_RS11060	COG0552	protein localization to endoplasmic reticulum
BUM88_RS11085	COG0517	IMP dehydrogenase activity
BUM88_RS11085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BUM88_RS11090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BUM88_RS11105	COG0583	DNA-binding transcription factor activity
BUM88_RS11110	COG0024	Methionine aminopeptidase
BUM88_RS11140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BUM88_RS11140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BUM88_RS11145	COG1105	Belongs to the carbohydrate kinase PfkB family
BUM88_RS11150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BUM88_RS11150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BUM88_RS11150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BUM88_RS11165	COG5001	Diguanylate cyclase
BUM88_RS11165	COG3300	MHYT domain
BUM88_RS11180	COG0659	secondary active sulfate transmembrane transporter activity
BUM88_RS11200	COG1113	amino acid transport
BUM88_RS11210	COG1522	sequence-specific DNA binding
BUM88_RS11225	COG1011	Hydrolase
BUM88_RS11230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BUM88_RS11240	COG2137	regulation of response to DNA damage stimulus
BUM88_RS11255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BUM88_RS11275	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BUM88_RS11290	COG0575	Belongs to the CDS family
BUM88_RS11295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BUM88_RS11320	COG3852	Histidine kinase
BUM88_RS11325	COG2204	response regulator
BUM88_RS11365	COG1335	isochorismatase
BUM88_RS11385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BUM88_RS11410	COG0697	spore germination
BUM88_RS11415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUM88_RS11425	COG0303	'Molybdopterin
BUM88_RS11430	COG0315	cyclic pyranopterin monophosphate synthase activity
BUM88_RS11430	COG0521	Mo-molybdopterin cofactor biosynthetic process
BUM88_RS11450	COG0243	molybdopterin cofactor binding
BUM88_RS11460	COG0243	molybdopterin cofactor binding
BUM88_RS11465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BUM88_RS11470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BUM88_RS11470	COG2146	nitrite reductase [NAD(P)H] activity
BUM88_RS11485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BUM88_RS11485	COG1116	anion transmembrane transporter activity
BUM88_RS11495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BUM88_RS11500	COG2423	ornithine cyclodeaminase activity
BUM88_RS11505	COG4264	IucA IucC family
BUM88_RS11515	COG4264	IucA IucC family
BUM88_RS11540	COG0511	ligase activity, forming carbon-carbon bonds
BUM88_RS11555	COG2814	Major facilitator Superfamily
BUM88_RS11585	COG0069	glutamate synthase activity
BUM88_RS11615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BUM88_RS11635	COG1454	alcohol dehydrogenase
BUM88_RS11640	COG0824	Thioesterase
BUM88_RS11650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BUM88_RS11680	COG2030	dehydratase
BUM88_RS11685	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS11690	COG0183	Belongs to the thiolase family
BUM88_RS11700	COG0583	DNA-binding transcription factor activity
BUM88_RS11705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BUM88_RS11715	COG1522	sequence-specific DNA binding
BUM88_RS11720	COG3135	benzoate transporter
BUM88_RS11740	COG0589	response to stress
BUM88_RS11745	COG0488	(ABC) transporter
BUM88_RS11765	COG3111	PFAM Bacterial OB fold (BOF) protein
BUM88_RS11780	COG0583	DNA-binding transcription factor activity
BUM88_RS11800	COG1733	regulation of RNA biosynthetic process
BUM88_RS11860	COG2205	protein histidine kinase activity
BUM88_RS11880	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS11885	COG1605	Chorismate mutase
BUM88_RS11925	COG0308	aminopeptidase N
BUM88_RS11950	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BUM88_RS11955	COG1454	alcohol dehydrogenase
BUM88_RS11975	COG0531	amino acid
BUM88_RS11980	COG4303	Ethanolamine ammonia lyase large subunit
BUM88_RS11985	COG4302	ethanolamine ammonia-lyase activity
BUM88_RS11990	COG0519	Catalyzes the synthesis of GMP from XMP
BUM88_RS11990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BUM88_RS11995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BUM88_RS12020	COG0697	spore germination
BUM88_RS12025	COG1923	regulation of RNA biosynthetic process
BUM88_RS12035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BUM88_RS12040	COG0802	atpase or kinase
BUM88_RS12060	COG1187	pseudouridine synthase activity
BUM88_RS12075	COG0583	DNA-binding transcription factor activity
BUM88_RS12090	COG2814	Major facilitator Superfamily
BUM88_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BUM88_RS12105	COG0471	metal ion transport
BUM88_RS12130	COG2706	6-phosphogluconolactonase activity
BUM88_RS12140	COG0729	surface antigen
BUM88_RS12160	COG0174	glutamine synthetase
BUM88_RS12165	COG0745	RESPONSE REGULATOR receiver
BUM88_RS12170	COG2205	protein histidine kinase activity
BUM88_RS12180	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BUM88_RS12185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BUM88_RS12195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BUM88_RS12210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS12215	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS12230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BUM88_RS12235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BUM88_RS12255	COG0583	DNA-binding transcription factor activity
BUM88_RS12270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS12280	COG3658	cytochrome
BUM88_RS12285	COG1215	transferase activity, transferring glycosyl groups
BUM88_RS12290	COG0726	polysaccharide deacetylase
BUM88_RS12290	COG1649	PFAM Uncharacterised BCR, COG1649
BUM88_RS12320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BUM88_RS12330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BUM88_RS12355	COG0305	Participates in initiation and elongation during chromosome replication
BUM88_RS12360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BUM88_RS12370	COG1305	Transglutaminase-like
BUM88_RS12380	COG2308	Evidence 4 Homologs of previously reported genes of
BUM88_RS12410	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BUM88_RS12415	COG0138	bifunctional purine biosynthesis protein purh
BUM88_RS12420	COG0151	Belongs to the GarS family
BUM88_RS12430	COG1464	Belongs to the NlpA lipoprotein family
BUM88_RS12435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BUM88_RS12440	COG2011	ABC-type metal ion transport system permease component
BUM88_RS12455	COG1301	dicarboxylic acid transport
BUM88_RS12485	COG2814	Major facilitator Superfamily
BUM88_RS12520	COG2855	membrane
BUM88_RS12540	COG3246	L-lysine catabolic process to acetate
BUM88_RS12545	COG2175	clavaminate synthase activity
BUM88_RS12555	COG1794	racemase activity, acting on amino acids and derivatives
BUM88_RS12560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BUM88_RS12585	COG0745	RESPONSE REGULATOR receiver
BUM88_RS12590	COG0642	Histidine kinase
BUM88_RS12595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BUM88_RS12605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BUM88_RS12645	COG2351	hydroxyisourate hydrolase activity
BUM88_RS12655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BUM88_RS12655	COG3008	intermembrane lipid transfer
BUM88_RS12660	COG2995	paraquat-inducible protein a
BUM88_RS12670	COG0583	DNA-binding transcription factor activity
BUM88_RS12685	COG2985	domain, Protein
BUM88_RS12710	COG0477	Major facilitator Superfamily
BUM88_RS12725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BUM88_RS12725	COG0475	glutathione-regulated potassium exporter activity
BUM88_RS12730	COG0786	glutamate:sodium symporter activity
BUM88_RS12735	COG3243	poly(R)-hydroxyalkanoic acid synthase
BUM88_RS12765	COG2085	NADP oxidoreductase coenzyme F420-dependent
BUM88_RS12770	COG1733	regulation of RNA biosynthetic process
BUM88_RS12775	COG4221	oxidoreductase activity
BUM88_RS12780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BUM88_RS12790	COG1309	transcriptional regulator
BUM88_RS12805	COG0534	Mate efflux family protein
BUM88_RS12835	COG1278	Cold shock
BUM88_RS12880	COG1610	YqeY-like protein
BUM88_RS12885	COG4783	chaperone-mediated protein folding
BUM88_RS12910	COG1286	toxin biosynthetic process
BUM88_RS12940	COG0778	Nitroreductase
BUM88_RS12950	COG0513	Belongs to the DEAD box helicase family
BUM88_RS12970	COG2363	Small membrane protein
BUM88_RS13000	COG4650	regulator
BUM88_RS13005	COG1234	tRNA 3'-trailer cleavage
BUM88_RS13010	COG1690	Belongs to the RtcB family
BUM88_RS13030	COG2195	Cleaves the N-terminal amino acid of tripeptides
BUM88_RS13040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BUM88_RS13050	COG2819	hydrolase of the alpha beta superfamily
BUM88_RS13060	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS13065	COG1301	dicarboxylic acid transport
BUM88_RS13085	COG3139	Protein of unknown function (DUF1315)
BUM88_RS13090	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BUM88_RS13095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BUM88_RS13105	COG0494	nUDIX hydrolase
BUM88_RS13115	COG0642	Histidine kinase
BUM88_RS13130	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BUM88_RS13140	COG1720	tRNA m6t6A37 methyltransferase activity
BUM88_RS13150	COG0384	phenazine biosynthesis protein PhzF
BUM88_RS13155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUM88_RS13165	COG4598	ABC transporter
BUM88_RS13170	COG4160	amino acid transport
BUM88_RS13195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS13240	COG1131	(ABC) transporter
BUM88_RS13245	COG0842	Transport permease protein
BUM88_RS13260	COG0772	Belongs to the SEDS family
BUM88_RS13265	COG2951	lytic endotransglycosylase activity
BUM88_RS13290	COG2207	Transcriptional regulator
BUM88_RS13305	COG0052	Belongs to the universal ribosomal protein uS2 family
BUM88_RS13310	COG0024	Methionine aminopeptidase
BUM88_RS13320	COG2223	nitrite transmembrane transporter activity
BUM88_RS13330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BUM88_RS13335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BUM88_RS13340	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS13345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BUM88_RS13355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BUM88_RS13360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BUM88_RS13365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BUM88_RS13375	COG0281	malic enzyme
BUM88_RS13375	COG0280	phosphate acetyltransferase
BUM88_RS13385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BUM88_RS13390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BUM88_RS13395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BUM88_RS13420	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BUM88_RS13430	COG0174	glutamine synthetase
BUM88_RS13450	COG0512	Glutamine amidotransferase of anthranilate synthase
BUM88_RS13475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BUM88_RS13485	COG0302	gtp cyclohydrolase
BUM88_RS13505	COG3739	integral membrane protein
BUM88_RS13525	COG1741	Belongs to the pirin family
BUM88_RS13535	COG2964	Protein conserved in bacteria
BUM88_RS13595	COG2879	small protein
BUM88_RS13600	COG1966	Carbon starvation protein
BUM88_RS13605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BUM88_RS13625	COG0254	rRNA binding
BUM88_RS13645	COG1067	ATP-dependent peptidase activity
BUM88_RS13650	COG0583	DNA-binding transcription factor activity
BUM88_RS13655	COG1388	LysM domain
BUM88_RS13655	COG4942	peptidase
BUM88_RS13675	COG1686	Belongs to the peptidase S11 family
BUM88_RS13680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BUM88_RS13720	COG0616	signal peptide processing
BUM88_RS13725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BUM88_RS13735	COG0573	inorganic phosphate transmembrane transporter activity
BUM88_RS13740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BUM88_RS13745	COG1113	amino acid transport
BUM88_RS13750	COG3961	Belongs to the TPP enzyme family
BUM88_RS13755	COG1522	sequence-specific DNA binding
BUM88_RS13765	COG0076	glutamate decarboxylase activity
BUM88_RS13770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BUM88_RS13830	COG0352	thiamine-phosphate diphosphorylase activity
BUM88_RS13855	COG0612	Peptidase, M16
BUM88_RS13865	COG1823	symporter activity
BUM88_RS13870	COG0583	DNA-binding transcription factor activity
BUM88_RS13875	COG0477	Major facilitator Superfamily
BUM88_RS13890	COG1187	pseudouridine synthase activity
BUM88_RS13905	COG1686	Belongs to the peptidase S11 family
BUM88_RS13910	COG1252	NADH dehydrogenase
BUM88_RS13920	COG0415	Belongs to the DNA photolyase family
BUM88_RS13935	COG1215	transferase activity, transferring glycosyl groups
BUM88_RS13960	COG2070	2-Nitropropane dioxygenase
BUM88_RS14015	COG0556	nucleotide-excision repair
BUM88_RS14040	COG0436	Aminotransferase
BUM88_RS14085	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BUM88_RS14095	COG0174	glutamine synthetase
BUM88_RS14115	COG0512	Glutamine amidotransferase of anthranilate synthase
BUM88_RS14140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BUM88_RS14150	COG0302	gtp cyclohydrolase
BUM88_RS14170	COG3739	integral membrane protein
BUM88_RS14190	COG1741	Belongs to the pirin family
BUM88_RS14200	COG2964	Protein conserved in bacteria
BUM88_RS14260	COG2879	small protein
BUM88_RS14265	COG1966	Carbon starvation protein
BUM88_RS14270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BUM88_RS14290	COG0254	rRNA binding
BUM88_RS14310	COG1067	ATP-dependent peptidase activity
BUM88_RS14315	COG0583	DNA-binding transcription factor activity
BUM88_RS14320	COG1388	LysM domain
BUM88_RS14320	COG4942	peptidase
BUM88_RS14340	COG1686	Belongs to the peptidase S11 family
BUM88_RS14345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BUM88_RS14385	COG0616	signal peptide processing
BUM88_RS14390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BUM88_RS14400	COG0573	inorganic phosphate transmembrane transporter activity
BUM88_RS14405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BUM88_RS14410	COG1113	amino acid transport
BUM88_RS14415	COG3961	Belongs to the TPP enzyme family
BUM88_RS14420	COG1522	sequence-specific DNA binding
BUM88_RS14430	COG0076	glutamate decarboxylase activity
BUM88_RS14435	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BUM88_RS14495	COG0352	thiamine-phosphate diphosphorylase activity
BUM88_RS14520	COG0612	Peptidase, M16
BUM88_RS14530	COG1823	symporter activity
BUM88_RS14535	COG0583	DNA-binding transcription factor activity
BUM88_RS14540	COG0477	Major facilitator Superfamily
BUM88_RS14555	COG1187	pseudouridine synthase activity
BUM88_RS14570	COG1686	Belongs to the peptidase S11 family
BUM88_RS14575	COG1252	NADH dehydrogenase
BUM88_RS14585	COG0415	Belongs to the DNA photolyase family
BUM88_RS14600	COG1215	transferase activity, transferring glycosyl groups
BUM88_RS14625	COG2070	2-Nitropropane dioxygenase
BUM88_RS14680	COG0556	nucleotide-excision repair
BUM88_RS14705	COG0436	Aminotransferase
BUM88_RS14730	COG4221	oxidoreductase activity
BUM88_RS14740	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BUM88_RS14755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BUM88_RS14760	COG0571	ribonuclease III activity
BUM88_RS14770	COG0681	Belongs to the peptidase S26 family
BUM88_RS14775	COG0481	GTPase activity
BUM88_RS14780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BUM88_RS14790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BUM88_RS14810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BUM88_RS14815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BUM88_RS14820	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BUM88_RS14830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BUM88_RS14835	COG4208	sulfate ABC transporter
BUM88_RS14840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BUM88_RS14845	COG0583	DNA-binding transcription factor activity
BUM88_RS14850	COG4625	pathogenesis
BUM88_RS14860	COG0602	queuosine metabolic process
BUM88_RS14865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BUM88_RS14880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BUM88_RS14895	COG1051	belongs to the nudix hydrolase family
BUM88_RS14895	COG1056	cytidyltransferase-related domain
BUM88_RS14900	COG1024	Enoyl-CoA hydratase
BUM88_RS14905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BUM88_RS14910	COG2814	Major facilitator Superfamily
BUM88_RS14915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BUM88_RS14915	COG0047	phosphoribosylformylglycinamidine synthase activity
BUM88_RS14935	COG1473	amidohydrolase
BUM88_RS14940	COG0824	Thioesterase
BUM88_RS14960	COG0823	Involved in the tonB-independent uptake of proteins
BUM88_RS14980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BUM88_RS15020	COG0628	permease
BUM88_RS15030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BUM88_RS15040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BUM88_RS15040	COG0616	signal peptide processing
BUM88_RS15050	COG0658	competence protein
BUM88_RS15050	COG2333	competence protein COMEC
BUM88_RS15055	COG1136	(ABC) transporter
BUM88_RS15060	COG4591	ABC-type transport system involved in lipoprotein release permease component
BUM88_RS15065	COG0697	spore germination
BUM88_RS15090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS15110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BUM88_RS15135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BUM88_RS15140	COG1280	lysine exporter protein (LysE YggA)
BUM88_RS15145	COG2267	carboxylic ester hydrolase activity
BUM88_RS15155	COG0019	diaminopimelate decarboxylase activity
BUM88_RS15165	COG1113	amino acid transport
BUM88_RS15195	COG1929	Belongs to the glycerate kinase type-1 family
BUM88_RS15210	COG0778	Nitroreductase
BUM88_RS15270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS15275	COG0583	DNA-binding transcription factor activity
BUM88_RS15295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BUM88_RS15300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BUM88_RS15320	COG0741	lytic transglycosylase activity
BUM88_RS15340	COG0584	glycerophosphoryl diester phosphodiesterase
BUM88_RS15345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BUM88_RS15370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BUM88_RS15375	COG1597	lipid kinase activity
BUM88_RS15390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BUM88_RS15395	COG0477	Major facilitator Superfamily
BUM88_RS15445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BUM88_RS15450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BUM88_RS15480	COG0505	Belongs to the CarA family
BUM88_RS15500	COG0589	response to stress
BUM88_RS15515	COG2843	Capsule synthesis protein
BUM88_RS15540	COG2321	neutral zinc metallopeptidase
BUM88_RS15545	COG2354	Protein conserved in bacteria
BUM88_RS15565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BUM88_RS15590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BUM88_RS15595	COG1053	succinate dehydrogenase
BUM88_RS15600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BUM88_RS15605	COG2009	succinate dehydrogenase
BUM88_RS15645	COG2921	Belongs to the UPF0250 family
BUM88_RS15650	COG0321	lipoyl(octanoyl) transferase activity
BUM88_RS15665	COG0531	amino acid
BUM88_RS15700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BUM88_RS15705	COG1648	precorrin-2 dehydrogenase activity
BUM88_RS15705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BUM88_RS15720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BUM88_RS15745	COG0671	phosphoesterase, PA-phosphatase related
BUM88_RS15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS15760	COG1538	Outer membrane efflux protein
BUM88_RS15765	COG0393	Putative heavy-metal-binding
BUM88_RS15770	COG0393	Putative heavy-metal-binding
BUM88_RS15775	COG2223	nitrite transmembrane transporter activity
BUM88_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
BUM88_RS15790	COG0525	valine-tRNA ligase activity
BUM88_RS15810	COG0583	DNA-binding transcription factor activity
BUM88_RS15815	COG0004	ammonium transporteR
BUM88_RS15825	COG0642	Histidine kinase
BUM88_RS15830	COG0745	RESPONSE REGULATOR receiver
BUM88_RS15835	COG2194	sulfuric ester hydrolase activity
BUM88_RS15860	COG1752	Esterase of the alpha-beta hydrolase superfamily
BUM88_RS15875	COG2315	Protein conserved in bacteria
BUM88_RS15880	COG0142	geranyltranstransferase activity
BUM88_RS15885	COG2828	Protein conserved in bacteria
BUM88_RS15890	COG1113	amino acid transport
BUM88_RS15950	COG2207	Transcriptional regulator
BUM88_RS15975	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUM88_RS15995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BUM88_RS16005	COG1530	ribonuclease E activity
BUM88_RS16010	COG0424	maF-like protein
BUM88_RS16015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BUM88_RS16020	COG1792	Involved in formation and maintenance of cell shape
BUM88_RS16025	COG1077	Cell shape determining protein MreB Mrl
BUM88_RS16030	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BUM88_RS16040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BUM88_RS16070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BUM88_RS16075	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BUM88_RS16080	COG1752	Esterase of the alpha-beta hydrolase superfamily
BUM88_RS16085	COG1115	amino acid carrier protein
BUM88_RS16105	COG2814	Major facilitator Superfamily
BUM88_RS16110	COG1289	transmembrane transporter activity
BUM88_RS16120	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BUM88_RS16145	COG1376	ErfK ybiS ycfS ynhG family protein
BUM88_RS16150	COG2832	Protein of unknown function (DUF454)
BUM88_RS16180	COG0840	transmembrane signaling receptor activity
BUM88_RS16220	COG3422	double-strand break repair
BUM88_RS16225	COG2824	Alkylphosphonate utilization operon protein PhnA
BUM88_RS16230	COG3189	MarR family transcriptional regulator
BUM88_RS16235	COG0596	Alpha beta hydrolase
BUM88_RS16245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BUM88_RS16250	COG1335	isochorismatase
BUM88_RS16255	COG0251	oxidation-reduction process
BUM88_RS16260	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS16265	COG2233	PERMEase
BUM88_RS16280	COG0354	folic acid binding
BUM88_RS16285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BUM88_RS16295	COG0679	Auxin Efflux Carrier
BUM88_RS16300	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS16305	COG4772	TonB-dependent receptor
BUM88_RS16310	COG2094	Belongs to the DNA glycosylase MPG family
BUM88_RS16335	COG1217	gtp-binding protein TYPA
BUM88_RS16340	COG2233	PERMEase
BUM88_RS16350	COG0833	amino acid
BUM88_RS16355	COG1690	Belongs to the RtcB family
BUM88_RS16360	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BUM88_RS16360	COG2885	chlorophyll binding
BUM88_RS16370	COG0183	Belongs to the thiolase family
BUM88_RS16390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BUM88_RS16410	COG2207	Transcriptional regulator
BUM88_RS16415	COG0183	Belongs to the thiolase family
BUM88_RS16435	COG2153	protein acetylation
BUM88_RS16445	COG1272	protein, Hemolysin III
BUM88_RS16450	COG0477	Major facilitator Superfamily
BUM88_RS16465	COG0450	alkyl hydroperoxide reductase
BUM88_RS16490	COG0285	dihydrofolate synthase activity
BUM88_RS16535	COG4206	TonB-dependent receptor
BUM88_RS16540	COG2096	Adenosyltransferase
BUM88_RS16560	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BUM88_RS16570	COG0745	RESPONSE REGULATOR receiver
BUM88_RS16575	COG2205	protein histidine kinase activity
BUM88_RS16585	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS16590	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS16595	COG0583	DNA-binding transcription factor activity
BUM88_RS16600	COG0625	glutathione transferase activity
BUM88_RS16635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BUM88_RS16665	COG0438	transferase activity, transferring glycosyl groups
BUM88_RS16670	COG0463	Glycosyl transferase, family 2
BUM88_RS16675	COG0726	polysaccharide deacetylase
BUM88_RS16695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BUM88_RS16700	COG4999	Histidine kinase
BUM88_RS16700	COG2205	protein histidine kinase activity
BUM88_RS16700	COG3437	response regulator, receiver
BUM88_RS16700	COG3850	Histidine kinase
BUM88_RS16725	COG0582	viral genome integration into host DNA
BUM88_RS16755	COG1862	Preprotein translocase
BUM88_RS16765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BUM88_RS16770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BUM88_RS16780	COG3781	membrane
BUM88_RS16785	COG0613	PHP domain protein
BUM88_RS16795	COG2350	Protein conserved in bacteria
BUM88_RS16825	COG1607	acyl-coa hydrolase
BUM88_RS16895	COG2199	diguanylate cyclase activity
BUM88_RS16900	COG2885	chlorophyll binding
BUM88_RS16905	COG1408	metallophosphoesterase
BUM88_RS16910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BUM88_RS16920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BUM88_RS16940	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BUM88_RS16945	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BUM88_RS16950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BUM88_RS16955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BUM88_RS16960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BUM88_RS16970	COG2969	positive regulation of protein catabolic process
BUM88_RS16990	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS16995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BUM88_RS17010	COG1309	transcriptional regulator
BUM88_RS17015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BUM88_RS17020	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS17070	COG1183	phosphatidylcholine synthase activity
BUM88_RS17075	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BUM88_RS17105	COG0739	heme binding
BUM88_RS17105	COG0741	lytic transglycosylase activity
BUM88_RS17105	COG1196	nuclear chromosome segregation
BUM88_RS17115	COG1702	phosphate starvation-inducible protein PhoH
BUM88_RS17150	COG1295	ribonuclease BN
BUM88_RS17155	COG0179	Fumarylacetoacetate (FAA) hydrolase
BUM88_RS17195	COG0557	exoribonuclease II activity
BUM88_RS17200	COG0339	signal peptide processing
BUM88_RS17205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BUM88_RS17235	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BUM88_RS17240	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS17315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BUM88_RS17355	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BUM88_RS17375	COG0088	Forms part of the polypeptide exit tunnel
BUM88_RS17380	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BUM88_RS17395	COG0626	cystathionine gamma-synthase activity
BUM88_RS17400	COG0433	COG0433 Predicted ATPase
BUM88_RS17405	COG1017	nitric oxide dioxygenase activity
BUM88_RS17405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BUM88_RS17410	COG1959	2 iron, 2 sulfur cluster binding
BUM88_RS17425	COG1301	dicarboxylic acid transport
BUM88_RS17430	COG1946	Acyl-CoA thioesterase
BUM88_RS17435	COG2937	Belongs to the GPAT DAPAT family
BUM88_RS17450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BUM88_RS17455	COG1040	competence protein
BUM88_RS17460	COG0494	nUDIX hydrolase
BUM88_RS17470	COG0598	Magnesium transport protein CorA
BUM88_RS17490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BUM88_RS17495	COG1127	ABC transporter
BUM88_RS17505	COG0513	Belongs to the DEAD box helicase family
BUM88_RS17525	COG0408	coproporphyrinogen oxidase activity
BUM88_RS17540	COG1960	acyl-CoA dehydrogenase activity
BUM88_RS17550	COG1983	PspC domain protein
BUM88_RS17555	COG0517	IMP dehydrogenase activity
BUM88_RS17585	COG0752	glycyl-tRNA synthetase alpha subunit
BUM88_RS17605	COG0583	DNA-binding transcription factor activity
BUM88_RS17610	COG1794	racemase activity, acting on amino acids and derivatives
BUM88_RS17615	COG0583	DNA-binding transcription factor activity
BUM88_RS17655	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS17665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BUM88_RS17670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BUM88_RS17675	COG0833	amino acid
BUM88_RS17705	COG1192	Involved in chromosome partitioning
BUM88_RS17710	COG0628	permease
BUM88_RS17720	COG1289	transmembrane transporter activity
BUM88_RS17740	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUM88_RS17745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BUM88_RS17760	COG0277	FAD linked oxidase domain protein
BUM88_RS17765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BUM88_RS17770	COG5006	permease, DMT superfamily
BUM88_RS17775	COG5006	permease, DMT superfamily
BUM88_RS17790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BUM88_RS17795	COG5380	lipid catabolic process
BUM88_RS17815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BUM88_RS17865	COG0194	GDP metabolic process
BUM88_RS17875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BUM88_RS17895	COG3307	-O-antigen
BUM88_RS17910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BUM88_RS17915	COG1704	LemA family
BUM88_RS17925	COG0493	'glutamate synthase
BUM88_RS17930	COG0069	glutamate synthase activity
BUM88_RS17930	COG0067	glutamate synthase
BUM88_RS17930	COG0070	glutamate synthase
BUM88_RS17980	COG2226	methyltransferase
BUM88_RS17995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BUM88_RS18000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BUM88_RS18045	COG0833	amino acid
BUM88_RS18100	COG0488	(ABC) transporter
BUM88_RS18105	COG2873	o-acetylhomoserine
BUM88_RS18110	COG4221	oxidoreductase activity
BUM88_RS18115	COG0659	secondary active sulfate transmembrane transporter activity
BUM88_RS18145	COG0427	acetyl-CoA hydrolase
BUM88_RS18175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BUM88_RS18205	COG2329	Antibiotic biosynthesis monooxygenase
BUM88_RS18220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BUM88_RS18280	COG0582	viral genome integration into host DNA
BUM88_RS18335	COG2207	Transcriptional regulator
BUM88_RS18340	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BUM88_RS18370	COG2249	NAD(P)H dehydrogenase (quinone) activity
BUM88_RS18375	COG1733	regulation of RNA biosynthetic process
BUM88_RS18415	COG0667	Aldo Keto reductase
BUM88_RS18455	COG0583	DNA-binding transcription factor activity
BUM88_RS18460	COG2814	Major facilitator Superfamily
BUM88_RS18505	COG1335	isochorismatase
BUM88_RS18515	COG0583	DNA-binding transcription factor activity
BUM88_RS18520	COG1335	isochorismatase
BUM88_RS18525	COG1012	belongs to the aldehyde dehydrogenase family
BUM88_RS18530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BUM88_RS18540	COG1113	amino acid transport
BUM88_RS18550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BUM88_RS18560	COG1132	(ABC) transporter
BUM88_RS18600	COG0629	single-stranded DNA binding
BUM88_RS18605	COG2814	Major facilitator Superfamily
BUM88_RS18615	COG0351	phosphomethylpyrimidine kinase
BUM88_RS18615	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BUM88_RS18615	COG0352	thiamine-phosphate diphosphorylase activity
BUM88_RS18625	COG4221	oxidoreductase activity
BUM88_RS18645	COG1309	transcriptional regulator
BUM88_RS18650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BUM88_RS18665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BUM88_RS18675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BUM88_RS18680	COG3162	membrane
BUM88_RS18685	COG2205	protein histidine kinase activity
BUM88_RS18685	COG2198	Histidine kinase
BUM88_RS18685	COG0784	Response regulator, receiver
BUM88_RS18710	COG1522	sequence-specific DNA binding
BUM88_RS18715	COG1335	isochorismatase
BUM88_RS18720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BUM88_RS18730	COG0668	transmembrane transport
BUM88_RS18735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BUM88_RS18740	COG1519	Transferase
BUM88_RS18745	COG1902	pentaerythritol trinitrate reductase activity
BUM88_RS18770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BUM88_RS18790	COG0426	domain, Protein
BUM88_RS18790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BUM88_RS18795	COG4774	siderophore transport
BUM88_RS18800	COG2119	membrane
BUM88_RS18810	COG0508	dehydrogenase complex catalyzes the overall conversion of
BUM88_RS18820	COG4942	peptidase
BUM88_RS18835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BUM88_RS18845	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BUM88_RS18865	COG0189	ligase activity
BUM88_RS18880	COG0456	acetyltransferase
BUM88_RS18890	COG0708	Exodeoxyribonuclease III
BUM88_RS18895	COG1393	Belongs to the ArsC family
BUM88_RS18910	COG3706	GGDEF domain
BUM88_RS18950	COG2233	PERMEase
BUM88_RS18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BUM88_RS18970	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BUM88_RS18980	COG3150	esterase
BUM88_RS19015	COG2918	glutathione biosynthetic process
BUM88_RS19030	COG2733	membrane
BUM88_RS19035	COG0436	Aminotransferase
BUM88_RS19040	COG0534	Mate efflux family protein
BUM88_RS19075	COG1910	domain protein
BUM88_RS19150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BUM88_RS19155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BUM88_RS19165	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BUM88_RS19180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BUM88_RS19190	COG0010	Belongs to the arginase family
BUM88_RS19220	COG2188	Transcriptional regulator
BUM88_RS19230	COG0523	cobalamin synthesis protein
BUM88_RS19240	COG1113	amino acid transport
BUM88_RS19250	COG0625	glutathione transferase activity
BUM88_RS19255	COG0346	lactoylglutathione lyase activity
BUM88_RS19270	COG1683	Conserved Protein
BUM88_RS19275	COG0534	Mate efflux family protein
BUM88_RS19280	COG0385	Bile acid
BUM88_RS19285	COG1335	isochorismatase
BUM88_RS19290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BUM88_RS19310	COG2116	formate transmembrane transporter activity
BUM88_RS19315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BUM88_RS19320	COG2133	pyrroloquinoline quinone binding
BUM88_RS19325	COG2983	Belongs to the UPF0260 family
BUM88_RS19345	COG1194	a g-specific adenine glycosylase
BUM88_RS19360	COG2818	Glycosylase
BUM88_RS19365	COG1064	alcohol dehydrogenase
BUM88_RS19370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BUM88_RS19385	COG0583	DNA-binding transcription factor activity
BUM88_RS19390	COG0656	L-ascorbic acid biosynthetic process
BUM88_RS19395	COG2814	Major facilitator Superfamily
BUM88_RS19430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BUM88_RS19445	COG2233	PERMEase
BUM88_RS19485	COG0733	neurotransmitter:sodium symporter activity
BUM88_RS19535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BUM88_RS19540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BUM88_RS19545	COG0596	Alpha beta hydrolase
BUM88_RS19575	COG0488	(ABC) transporter
BUM88_RS19590	COG0187	DNA topoisomerase II activity
BUM88_RS19600	COG0592	DNA-directed DNA polymerase activity
BUM88_RS19625	COG0706	membrane insertase activity
BUM88_RS19640	COG1230	cation diffusion facilitator family transporter
BUM88_RS19660	COG0402	S-adenosylhomocysteine deaminase activity
BUM88_RS19670	COG0754	glutathionylspermidine amidase activity
BUM88_RS19685	COG0861	Integral membrane protein TerC family
BUM88_RS19690	COG0671	phosphoesterase, PA-phosphatase related
BUM88_RS19700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BUM88_RS19715	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BUM88_RS19720	COG2951	lytic endotransglycosylase activity
BUM88_RS19775	COG0657	acetylesterase activity
BUM88_RS19780	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides