locus-tag	class	description
I6J48_RS00015	COG4771	TonB-dependent receptor
I6J48_RS00020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J48_RS00025	COG1535	isochorismatase
I6J48_RS00025	COG3433	isochorismatase activity
I6J48_RS00030	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J48_RS00035	COG1169	isochorismate synthase
I6J48_RS00040	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS00050	COG3251	PFAM MbtH domain protein
I6J48_RS00055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J48_RS00080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6J48_RS00085	COG4149	molybdate abc transporter
I6J48_RS00090	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6J48_RS00100	COG4638	Rieske (2fe-2S)
I6J48_RS00105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J48_RS00110	COG0543	2 iron, 2 sulfur cluster binding
I6J48_RS00110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J48_RS00135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS00155	COG2207	Transcriptional regulator
I6J48_RS00160	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS00165	COG2610	gluconate transmembrane transporter activity
I6J48_RS00200	COG0583	DNA-binding transcription factor activity
I6J48_RS00215	COG2031	fatty acid transporter
I6J48_RS00220	COG0183	Belongs to the thiolase family
I6J48_RS00225	COG0583	DNA-binding transcription factor activity
I6J48_RS00230	COG0583	DNA-binding transcription factor activity
I6J48_RS00245	COG1027	Aspartate ammonia-lyase
I6J48_RS00255	COG0477	Major facilitator Superfamily
I6J48_RS00275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS00280	COG4521	taurine ABC transporter
I6J48_RS00295	COG2188	Transcriptional regulator
I6J48_RS00305	COG3708	Transcriptional regulator
I6J48_RS00305	COG2207	Transcriptional regulator
I6J48_RS00320	COG0730	response to heat
I6J48_RS00330	COG3453	Protein conserved in bacteria
I6J48_RS00330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J48_RS00355	COG1063	alcohol dehydrogenase
I6J48_RS00365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J48_RS00370	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J48_RS00375	COG0022	dehydrogenase e1 component
I6J48_RS00380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J48_RS00385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J48_RS00400	COG3706	GGDEF domain
I6J48_RS00420	COG0133	tryptophan synthase activity
I6J48_RS00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J48_RS00460	COG0583	DNA-binding transcription factor activity
I6J48_RS00465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J48_RS00475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J48_RS00535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J48_RS00540	COG4773	Receptor
I6J48_RS00555	COG0730	response to heat
I6J48_RS00560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J48_RS00575	COG0406	alpha-ribazole phosphatase activity
I6J48_RS00595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J48_RS00600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J48_RS00615	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS00620	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS00625	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J48_RS00630	COG2207	Transcriptional regulator
I6J48_RS00635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J48_RS00640	COG0776	regulation of translation
I6J48_RS00665	COG0822	iron-sulfur transferase activity
I6J48_RS00670	COG0316	Belongs to the HesB IscA family
I6J48_RS00700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J48_RS00720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6J48_RS00725	COG0702	epimerase
I6J48_RS00755	COG4172	Belongs to the ABC transporter superfamily
I6J48_RS00765	COG0601	transmembrane transport
I6J48_RS00770	COG0339	signal peptide processing
I6J48_RS00775	COG4166	transmembrane transport
I6J48_RS00790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
I6J48_RS00815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6J48_RS00820	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6J48_RS00835	COG2431	L-lysine efflux transmembrane transporter activity
I6J48_RS00850	COG0776	regulation of translation
I6J48_RS00915	COG0084	hydrolase, TatD family'
I6J48_RS00935	COG1663	tetraacyldisaccharide 4'-kinase activity
I6J48_RS00940	COG1132	(ABC) transporter
I6J48_RS00950	COG0811	peptide transport
I6J48_RS00955	COG1475	DNA binding
I6J48_RS00960	COG1192	Involved in chromosome partitioning
I6J48_RS00970	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I6J48_RS00985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J48_RS00990	COG0191	fructose-bisphosphate aldolase activity
I6J48_RS01010	COG0424	maF-like protein
I6J48_RS01015	COG2850	peptidyl-arginine hydroxylation
I6J48_RS01025	COG0640	Transcriptional regulator
I6J48_RS01035	COG3619	membrane
I6J48_RS01040	COG3122	Protein conserved in bacteria
I6J48_RS01045	COG1132	(ABC) transporter
I6J48_RS01065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6J48_RS01070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J48_RS01080	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J48_RS01080	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6J48_RS01080	COG0506	proline dehydrogenase activity
I6J48_RS01085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J48_RS01100	COG3698	Phosphodiester glycosidase
I6J48_RS01110	COG2353	YceI-like domain
I6J48_RS01120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J48_RS01165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6J48_RS01165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J48_RS01190	COG3539	Fimbrial protein
I6J48_RS01225	COG0583	DNA-binding transcription factor activity
I6J48_RS01230	COG0697	spore germination
I6J48_RS01240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6J48_RS01250	COG0583	DNA-binding transcription factor activity
I6J48_RS01265	COG1309	transcriptional regulator
I6J48_RS01280	COG1522	sequence-specific DNA binding
I6J48_RS01290	COG1126	abc transporter atp-binding protein
I6J48_RS01295	COG0765	amino acid transport
I6J48_RS01300	COG0765	amino acid transport
I6J48_RS01305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J48_RS01330	COG1464	Belongs to the NlpA lipoprotein family
I6J48_RS01335	COG1464	Belongs to the NlpA lipoprotein family
I6J48_RS01340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J48_RS01345	COG2011	ABC-type metal ion transport system permease component
I6J48_RS01350	COG0012	GTP binding
I6J48_RS01375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J48_RS01410	COG1917	Cupin 2, conserved barrel domain protein
I6J48_RS01410	COG2207	Transcriptional regulator
I6J48_RS01415	COG0386	Belongs to the glutathione peroxidase family
I6J48_RS01425	COG0436	Aminotransferase
I6J48_RS01430	COG1301	dicarboxylic acid transport
I6J48_RS01465	COG3634	alkyl hydroperoxide reductase activity
I6J48_RS01480	COG0583	DNA-binding transcription factor activity
I6J48_RS01485	COG0431	NADPH-dependent FMN reductase
I6J48_RS01490	COG0798	PFAM Bile acid sodium symporter
I6J48_RS01500	COG0640	Transcriptional regulator
I6J48_RS01515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6J48_RS01525	COG0583	DNA-binding transcription factor activity
I6J48_RS01535	COG1953	Uracil, thiamine, allantoin
I6J48_RS01545	COG2175	clavaminate synthase activity
I6J48_RS01550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS01555	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I6J48_RS01560	COG4521	taurine ABC transporter
I6J48_RS01570	COG0477	Major facilitator Superfamily
I6J48_RS01590	COG1271	oxidase subunit
I6J48_RS01595	COG1294	oxidase, subunit
I6J48_RS01605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J48_RS01625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J48_RS01645	COG3052	prosthetic group binding
I6J48_RS01650	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6J48_RS01660	COG2814	Major facilitator Superfamily
I6J48_RS01670	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS01675	COG2207	Transcriptional regulator
I6J48_RS01675	COG1917	Cupin 2, conserved barrel domain protein
I6J48_RS01695	COG1346	cytolysis
I6J48_RS01705	COG0583	DNA-binding transcription factor activity
I6J48_RS01710	COG0625	glutathione transferase activity
I6J48_RS01715	COG0625	glutathione transferase activity
I6J48_RS01740	COG1045	serine acetyltransferase
I6J48_RS01745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J48_RS01750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J48_RS01755	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS01760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J48_RS01775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J48_RS01780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J48_RS01790	COG0765	amino acid transport
I6J48_RS01795	COG0765	amino acid transport
I6J48_RS01835	COG2205	protein histidine kinase activity
I6J48_RS01835	COG0784	Response regulator, receiver
I6J48_RS01855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6J48_RS01875	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS01910	COG0583	DNA-binding transcription factor activity
I6J48_RS01920	COG2814	Major facilitator Superfamily
I6J48_RS01935	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS01940	COG1309	transcriptional regulator
I6J48_RS01945	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS01950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J48_RS01955	COG1024	Enoyl-CoA hydratase
I6J48_RS01960	COG4770	biotin carboxylase activity
I6J48_RS01970	COG0583	DNA-binding transcription factor activity
I6J48_RS01985	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS01995	COG2814	Major facilitator Superfamily
I6J48_RS02005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J48_RS02010	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J48_RS02015	COG2814	Major facilitator Superfamily
I6J48_RS02020	COG2814	Major facilitator Superfamily
I6J48_RS02025	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS02030	COG1024	Enoyl-CoA hydratase
I6J48_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J48_RS02045	COG0183	Belongs to the thiolase family
I6J48_RS02055	COG2814	Major facilitator Superfamily
I6J48_RS02065	COG1024	Enoyl-CoA hydratase
I6J48_RS02075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J48_RS02080	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS02085	COG2814	Major facilitator Superfamily
I6J48_RS02090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J48_RS02095	COG1414	Transcriptional regulator
I6J48_RS02125	COG0210	DNA helicase
I6J48_RS02135	COG2050	protein possibly involved in aromatic compounds catabolism
I6J48_RS02145	COG3327	negative regulation of DNA-templated transcription, initiation
I6J48_RS02150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6J48_RS02155	COG0183	Belongs to the thiolase family
I6J48_RS02160	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J48_RS02165	COG1024	Enoyl-CoA hydratase
I6J48_RS02170	COG1024	Enoyl-CoA hydratase
I6J48_RS02175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J48_RS02180	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J48_RS02185	COG3396	Phenylacetate-CoA oxygenase
I6J48_RS02190	COG3460	Phenylacetate-CoA oxygenase
I6J48_RS02195	COG3396	Phenylacetate-CoA oxygenase
I6J48_RS02200	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS02200	COG2030	dehydratase
I6J48_RS02205	COG1760	l-serine dehydratase
I6J48_RS02220	COG0789	Transcriptional regulator
I6J48_RS02230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J48_RS02240	COG2807	transmembrane transport
I6J48_RS02245	COG0590	tRNA wobble adenosine to inosine editing
I6J48_RS02295	COG2885	chlorophyll binding
I6J48_RS02350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J48_RS02400	COG0477	Major facilitator Superfamily
I6J48_RS02415	COG1116	anion transmembrane transporter activity
I6J48_RS02420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J48_RS02430	COG0864	Transcriptional regulator
I6J48_RS02445	COG1733	regulation of RNA biosynthetic process
I6J48_RS02450	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J48_RS02455	COG0439	Biotin carboxylase
I6J48_RS02470	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6J48_RS02515	COG0038	chloride channel
I6J48_RS02520	COG4770	biotin carboxylase activity
I6J48_RS02540	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J48_RS02585	COG0640	Transcriptional regulator
I6J48_RS02600	COG1309	transcriptional regulator
I6J48_RS02625	COG1051	belongs to the nudix hydrolase family
I6J48_RS02630	COG1309	transcriptional regulator
I6J48_RS02655	COG2259	Doxx family
I6J48_RS02670	COG3712	iron ion homeostasis
I6J48_RS02745	COG0531	amino acid
I6J48_RS02750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J48_RS02765	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J48_RS02780	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6J48_RS02795	COG4122	O-methyltransferase activity
I6J48_RS02825	COG1538	Outer membrane efflux protein
I6J48_RS02830	COG1137	ATPase activity
I6J48_RS02835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6J48_RS02845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6J48_RS02885	COG2814	Major facilitator Superfamily
I6J48_RS02915	COG0668	transmembrane transport
I6J48_RS02985	COG2226	methyltransferase
I6J48_RS03010	COG1278	Cold shock
I6J48_RS03015	COG1560	Kdo2-lipid A biosynthetic process
I6J48_RS03020	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS03055	COG1570	exodeoxyribonuclease VII activity
I6J48_RS03105	COG0583	DNA-binding transcription factor activity
I6J48_RS03115	COG4638	Rieske (2fe-2S)
I6J48_RS03120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6J48_RS03125	COG0633	Ferredoxin
I6J48_RS03125	COG0543	2 iron, 2 sulfur cluster binding
I6J48_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS03135	COG3135	benzoate transporter
I6J48_RS03140	COG2814	Major facilitator Superfamily
I6J48_RS03155	COG1643	Atp-dependent helicase
I6J48_RS03170	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J48_RS03190	COG3634	alkyl hydroperoxide reductase activity
I6J48_RS03210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J48_RS03220	COG0625	glutathione transferase activity
I6J48_RS03230	COG2885	chlorophyll binding
I6J48_RS03265	COG0542	response to heat
I6J48_RS03280	COG1765	OsmC-like protein
I6J48_RS03290	COG0667	Aldo Keto reductase
I6J48_RS03305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J48_RS03320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6J48_RS03330	COG0527	aspartate kinase activity
I6J48_RS03340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J48_RS03350	COG3038	cytochrome b561
I6J48_RS03355	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6J48_RS03360	COG2252	PERMEase
I6J48_RS03370	COG1741	Belongs to the pirin family
I6J48_RS03375	COG1309	transcriptional regulator
I6J48_RS03385	COG0300	oxidoreductase activity
I6J48_RS03390	COG2072	flavoprotein involved in K transport
I6J48_RS03395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6J48_RS03425	COG1944	ATP diphosphatase activity
I6J48_RS03445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J48_RS03460	COG2814	Major facilitator Superfamily
I6J48_RS03465	COG1024	Enoyl-CoA hydratase
I6J48_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS03480	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS03505	COG2186	Transcriptional regulator
I6J48_RS03510	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS03520	COG4948	Mandelate Racemase Muconate Lactonizing
I6J48_RS03525	COG2271	Major facilitator Superfamily
I6J48_RS03530	COG2721	sulfolactate sulfo-lyase activity
I6J48_RS03535	COG0697	spore germination
I6J48_RS03565	COG3210	domain, Protein
I6J48_RS03570	COG2831	hemolysin activation secretion protein
I6J48_RS03575	COG1113	amino acid transport
I6J48_RS03595	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS03615	COG0531	amino acid
I6J48_RS03625	COG1113	amino acid transport
I6J48_RS03665	COG1309	transcriptional regulator
I6J48_RS03670	COG4269	membrane
I6J48_RS03725	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J48_RS03725	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS03735	COG2203	Gaf domain
I6J48_RS03735	COG3706	GGDEF domain
I6J48_RS03735	COG5001	Diguanylate cyclase
I6J48_RS03735	COG4251	negative regulation of phosphorylation
I6J48_RS03745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J48_RS03770	COG4172	Belongs to the ABC transporter superfamily
I6J48_RS03775	COG4239	(ABC) transporter, permease
I6J48_RS03780	COG4174	ABC transporter (Permease)
I6J48_RS03785	COG4166	transmembrane transport
I6J48_RS03790	COG0741	lytic transglycosylase activity
I6J48_RS03790	COG1388	LysM domain
I6J48_RS03790	COG1388	LysM domain
I6J48_RS03790	COG0741	lytic transglycosylase activity
I6J48_RS03835	COG0583	DNA-binding transcription factor activity
I6J48_RS03850	COG0789	Transcriptional regulator
I6J48_RS03860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J48_RS03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J48_RS03870	COG0006	proline dipeptidase activity
I6J48_RS03910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J48_RS03925	COG3384	dioxygenase
I6J48_RS03935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J48_RS03940	COG2878	Part of a membrane complex involved in electron transport
I6J48_RS03945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J48_RS03970	COG0768	penicillin binding
I6J48_RS03975	COG0742	ribosomal rna small subunit methyltransferase
I6J48_RS03990	COG0830	nickel cation binding
I6J48_RS04000	COG0804	urea catabolic process
I6J48_RS04025	COG3015	lipoprotein NlpE involved in copper resistance
I6J48_RS04040	COG1253	flavin adenine dinucleotide binding
I6J48_RS04045	COG2851	Citrate transporter
I6J48_RS04095	COG1773	rubredoxin
I6J48_RS04100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J48_RS04110	COG0583	DNA-binding transcription factor activity
I6J48_RS04140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6J48_RS04145	COG4181	ATPase activity
I6J48_RS04190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J48_RS04210	COG0306	phosphate transporter
I6J48_RS04230	COG3958	Transketolase
I6J48_RS04235	COG3959	Transketolase, thiamine diphosphate binding domain
I6J48_RS04240	COG2271	Major facilitator Superfamily
I6J48_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS04250	COG0583	DNA-binding transcription factor activity
I6J48_RS04265	COG2223	nitrite transmembrane transporter activity
I6J48_RS04275	COG2066	Belongs to the glutaminase family
I6J48_RS04280	COG0242	peptide deformylase activity
I6J48_RS04285	COG0477	Major facilitator Superfamily
I6J48_RS04295	COG0028	Belongs to the TPP enzyme family
I6J48_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS04325	COG2271	Major facilitator Superfamily
I6J48_RS04340	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS04360	COG1414	Transcriptional regulator
I6J48_RS04380	COG1024	Enoyl-CoA hydratase
I6J48_RS04390	COG1309	transcriptional regulator
I6J48_RS04400	COG1215	transferase activity, transferring glycosyl groups
I6J48_RS04405	COG1649	PFAM Uncharacterised BCR, COG1649
I6J48_RS04405	COG0726	polysaccharide deacetylase
I6J48_RS04415	COG4681	YaeQ
I6J48_RS04425	COG0523	cobalamin synthesis protein
I6J48_RS04435	COG1607	acyl-coa hydrolase
I6J48_RS04445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J48_RS04450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J48_RS04455	COG1309	transcriptional regulator
I6J48_RS04480	COG2040	homocysteine
I6J48_RS04485	COG0531	amino acid
I6J48_RS04540	COG1595	DNA-templated transcription, initiation
I6J48_RS04550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J48_RS04555	COG0477	Major facilitator Superfamily
I6J48_RS04575	COG1396	sequence-specific DNA binding
I6J48_RS04600	COG1401	restriction endodeoxyribonuclease activity
I6J48_RS04605	COG3727	T/G mismatch-specific endonuclease activity
I6J48_RS04610	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J48_RS04630	COG0405	Gamma-glutamyltransferase
I6J48_RS04635	COG2814	Major facilitator Superfamily
I6J48_RS04640	COG1566	PFAM secretion protein HlyD family protein
I6J48_RS04645	COG2050	protein possibly involved in aromatic compounds catabolism
I6J48_RS04660	COG1090	epimerase
I6J48_RS04680	COG0420	3'-5' exonuclease activity
I6J48_RS04705	COG0735	belongs to the Fur family
I6J48_RS04710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J48_RS04715	COG2914	Belongs to the UPF0125 (RnfH) family
I6J48_RS04730	COG0121	glutamine amidotransferase
I6J48_RS04745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J48_RS04755	COG0210	DNA helicase
I6J48_RS04760	COG2885	chlorophyll binding
I6J48_RS04765	COG0204	Acyl-transferase
I6J48_RS04800	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS04805	COG1674	ftsk spoiiie
I6J48_RS04810	COG0492	ferredoxin-NADP+ reductase activity
I6J48_RS04820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6J48_RS04830	COG0456	acetyltransferase
I6J48_RS04845	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J48_RS04850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J48_RS04855	COG0049	tRNA binding
I6J48_RS04860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J48_RS04875	COG1981	membrane
I6J48_RS04885	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J48_RS04885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J48_RS04915	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6J48_RS04955	COG0358	DNA primase activity
I6J48_RS04970	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6J48_RS05000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J48_RS05030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J48_RS05040	COG0352	thiamine-phosphate diphosphorylase activity
I6J48_RS05040	COG0351	phosphomethylpyrimidine kinase
I6J48_RS05040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J48_RS05045	COG1652	LysM domain
I6J48_RS05055	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS05070	COG1399	metal-binding, possibly nucleic acid-binding protein
I6J48_RS05075	COG3101	peptidyl-lysine hydroxylation
I6J48_RS05080	COG0009	L-threonylcarbamoyladenylate synthase
I6J48_RS05085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J48_RS05090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J48_RS05105	COG4106	trans-aconitate 2-methyltransferase activity
I6J48_RS05120	COG0596	Alpha beta hydrolase
I6J48_RS05120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J48_RS05120	COG2226	methyltransferase
I6J48_RS05130	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6J48_RS05135	COG2223	nitrite transmembrane transporter activity
I6J48_RS05155	COG1196	nuclear chromosome segregation
I6J48_RS05165	COG0730	response to heat
I6J48_RS05180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J48_RS05190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J48_RS05235	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J48_RS05240	COG0489	protein tyrosine kinase activity
I6J48_RS05250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J48_RS05250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J48_RS05290	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6J48_RS05295	COG2081	HI0933 family
I6J48_RS05305	COG0668	transmembrane transport
I6J48_RS05325	COG0583	DNA-binding transcription factor activity
I6J48_RS05345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J48_RS05350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J48_RS05365	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6J48_RS05380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6J48_RS05405	COG2199	diguanylate cyclase activity
I6J48_RS05420	COG0745	RESPONSE REGULATOR receiver
I6J48_RS05440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J48_RS05455	COG3781	membrane
I6J48_RS05460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6J48_RS05485	COG0303	'Molybdopterin
I6J48_RS05490	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J48_RS05490	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J48_RS05495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6J48_RS05505	COG1294	oxidase, subunit
I6J48_RS05510	COG1271	oxidase subunit
I6J48_RS05515	COG0384	phenazine biosynthesis protein PhzF
I6J48_RS05560	COG1309	transcriptional regulator
I6J48_RS05565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J48_RS05580	COG0583	DNA-binding transcription factor activity
I6J48_RS05610	COG0583	DNA-binding transcription factor activity
I6J48_RS05625	COG0583	DNA-binding transcription factor activity
I6J48_RS05630	COG1053	succinate dehydrogenase
I6J48_RS05645	COG1309	transcriptional regulator
I6J48_RS05655	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6J48_RS05660	COG2814	Major facilitator Superfamily
I6J48_RS05665	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS05670	COG0583	DNA-binding transcription factor activity
I6J48_RS05675	COG1063	alcohol dehydrogenase
I6J48_RS05705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J48_RS05710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J48_RS05730	COG3667	copper resistance
I6J48_RS05735	COG2132	Multicopper oxidase
I6J48_RS05745	COG0561	phosphatase activity
I6J48_RS05750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J48_RS05775	COG1214	PFAM Peptidase M22, glycoprotease
I6J48_RS05785	COG0494	nUDIX hydrolase
I6J48_RS05835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J48_RS05840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6J48_RS05845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J48_RS05905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J48_RS05915	COG1846	Transcriptional regulator
I6J48_RS05920	COG1764	response to oxidative stress
I6J48_RS05960	COG0037	tRNA processing
I6J48_RS05970	COG0248	Ppx GppA phosphatase
I6J48_RS06000	COG0072	phenylalanine-tRNA ligase activity
I6J48_RS06030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J48_RS06040	COG1238	metal cluster binding
I6J48_RS06045	COG0625	glutathione transferase activity
I6J48_RS06050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J48_RS06060	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS06065	COG3028	Belongs to the UPF0307 family
I6J48_RS06070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J48_RS06090	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J48_RS06095	COG0617	tRNA 3'-terminal CCA addition
I6J48_RS06100	COG1555	photosystem II stabilization
I6J48_RS06105	COG3956	TIGRFAM MazG family protein
I6J48_RS06110	COG4221	oxidoreductase activity
I6J48_RS06115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J48_RS06130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J48_RS06135	COG5002	protein histidine kinase activity
I6J48_RS06135	COG0784	Response regulator, receiver
I6J48_RS06135	COG2205	protein histidine kinase activity
I6J48_RS06140	COG1024	Enoyl-CoA hydratase
I6J48_RS06145	COG2084	Dehydrogenase
I6J48_RS06150	COG3622	Belongs to the hyi family
I6J48_RS06185	COG0697	spore germination
I6J48_RS06195	COG2814	Major facilitator Superfamily
I6J48_RS06200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J48_RS06215	COG0583	DNA-binding transcription factor activity
I6J48_RS06225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6J48_RS06235	COG0084	hydrolase, TatD family'
I6J48_RS06250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6J48_RS06275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6J48_RS06280	COG0440	acetolactate synthase activity
I6J48_RS06285	COG0028	Belongs to the TPP enzyme family
I6J48_RS06305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS06310	COG0577	efflux transmembrane transporter activity
I6J48_RS06310	COG1136	(ABC) transporter
I6J48_RS06335	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6J48_RS06340	COG1162	GTPase activity
I6J48_RS06350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J48_RS06370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J48_RS06375	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS06415	COG2986	histidine ammonia-lyase
I6J48_RS06425	COG1216	Glycosyl transferase, family 2
I6J48_RS06430	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS06440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J48_RS06465	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J48_RS06485	COG1426	Protein conserved in bacteria
I6J48_RS06505	COG2975	iron-sulfur cluster assembly
I6J48_RS06520	COG0793	Belongs to the peptidase S41A family
I6J48_RS06535	COG2267	carboxylic ester hydrolase activity
I6J48_RS06545	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS06550	COG3265	gluconokinase activity
I6J48_RS06560	COG0800	Aldolase
I6J48_RS06575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J48_RS06580	COG0857	belongs to the CobB CobQ family
I6J48_RS06580	COG0280	phosphate acetyltransferase
I6J48_RS06585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J48_RS06585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6J48_RS06605	COG0740	serine-type endopeptidase activity
I6J48_RS06615	COG4774	siderophore transport
I6J48_RS06625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6J48_RS06635	COG2813	Specifically methylates the guanine in position
I6J48_RS06635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J48_RS06735	COG0788	formyltetrahydrofolate deformylase activity
I6J48_RS06760	COG4651	solute:proton antiporter activity
I6J48_RS06760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J48_RS06780	COG0724	RNA recognition motif
I6J48_RS06785	COG0210	DNA helicase
I6J48_RS06810	COG1733	regulation of RNA biosynthetic process
I6J48_RS06815	COG0604	alcohol dehydrogenase
I6J48_RS06820	COG2900	Belongs to the SlyX family
I6J48_RS06825	COG0488	(ABC) transporter
I6J48_RS06835	COG1560	Kdo2-lipid A biosynthetic process
I6J48_RS06845	COG1301	dicarboxylic acid transport
I6J48_RS06900	COG0473	3-isopropylmalate dehydrogenase activity
I6J48_RS06925	COG0583	DNA-binding transcription factor activity
I6J48_RS06970	COG0583	DNA-binding transcription factor activity
I6J48_RS06980	COG0625	glutathione transferase activity
I6J48_RS06985	COG2378	regulation of single-species biofilm formation
I6J48_RS07000	COG1530	ribonuclease E activity
I6J48_RS07005	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS07020	COG0583	DNA-binding transcription factor activity
I6J48_RS07025	COG4221	oxidoreductase activity
I6J48_RS07030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J48_RS07040	COG0534	Mate efflux family protein
I6J48_RS07055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6J48_RS07085	COG0493	'glutamate synthase
I6J48_RS07095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6J48_RS07100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J48_RS07115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J48_RS07125	COG0644	oxidoreductase
I6J48_RS07125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6J48_RS07140	COG4535	Mg2 and Co2 transporter CorC
I6J48_RS07145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6J48_RS07150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J48_RS07175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J48_RS07180	COG0475	glutathione-regulated potassium exporter activity
I6J48_RS07180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J48_RS07185	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J48_RS07195	COG0484	heat shock protein binding
I6J48_RS07200	COG0789	Transcriptional regulator
I6J48_RS07205	COG0598	Magnesium transport protein CorA
I6J48_RS07210	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J48_RS07220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J48_RS07225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J48_RS07230	COG1074	ATP-dependent DNA helicase activity
I6J48_RS07235	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6J48_RS07255	COG2226	methyltransferase
I6J48_RS07270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J48_RS07280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6J48_RS07295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6J48_RS07295	COG2111	Na H antiporter
I6J48_RS07300	COG1006	Multisubunit Na H antiporter MnhC subunit
I6J48_RS07305	COG0651	ATP synthesis coupled electron transport
I6J48_RS07310	COG1863	multisubunit Na H antiporter MnhE subunit
I6J48_RS07315	COG2212	antiporter activity
I6J48_RS07320	COG1320	monovalent cation:proton antiporter activity
I6J48_RS07325	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J48_RS07335	COG0195	Participates in both transcription termination and antitermination
I6J48_RS07380	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6J48_RS07385	COG0237	dephospho-CoA kinase activity
I6J48_RS07395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J48_RS07410	COG0497	DNA recombination
I6J48_RS07420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J48_RS07455	COG2169	Transcriptional regulator
I6J48_RS07455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J48_RS07460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J48_RS07530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6J48_RS07545	COG0326	Molecular chaperone. Has ATPase activity
I6J48_RS07560	COG2056	Na+-H+ antiporter family
I6J48_RS07595	COG0222	ribosome binding
I6J48_RS07600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J48_RS07630	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J48_RS07660	COG0546	phosphoglycolate phosphatase activity
I6J48_RS07665	COG1716	ATPase activity
I6J48_RS07710	COG0181	hydroxymethylbilane synthase activity
I6J48_RS07720	COG3275	phosphorelay sensor kinase activity
I6J48_RS07740	COG1538	Outer membrane efflux protein
I6J48_RS07775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J48_RS07780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6J48_RS07785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J48_RS07790	COG0772	Belongs to the SEDS family
I6J48_RS07815	COG4974	Belongs to the 'phage' integrase family
I6J48_RS07820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J48_RS07830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J48_RS07840	COG2197	response regulator
I6J48_RS07855	COG0793	Belongs to the peptidase S41A family
I6J48_RS07860	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6J48_RS07865	COG0795	lipopolysaccharide-transporting ATPase activity
I6J48_RS07905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J48_RS07905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J48_RS07915	COG0004	ammonium transporteR
I6J48_RS07920	COG0347	Belongs to the P(II) protein family
I6J48_RS07930	COG0606	chelatase, subunit chli
I6J48_RS07935	COG0431	NADPH-dependent FMN reductase
I6J48_RS07955	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6J48_RS07970	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS07980	COG0477	Major facilitator Superfamily
I6J48_RS07985	COG2860	membrane
I6J48_RS07995	COG1253	flavin adenine dinucleotide binding
I6J48_RS08005	COG2814	Major facilitator Superfamily
I6J48_RS08015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J48_RS08040	COG0789	Transcriptional regulator
I6J48_RS08050	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6J48_RS08065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6J48_RS08100	COG1309	transcriptional regulator
I6J48_RS08135	COG0758	DNA mediated transformation
I6J48_RS08145	COG0697	spore germination
I6J48_RS08150	COG1309	transcriptional regulator
I6J48_RS08165	COG0386	Belongs to the glutathione peroxidase family
I6J48_RS08175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6J48_RS08180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6J48_RS08185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J48_RS08230	COG1121	(ABC) transporter
I6J48_RS08235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J48_RS08245	COG2837	iron assimilation
I6J48_RS08255	COG0281	malic enzyme
I6J48_RS08305	COG2084	Dehydrogenase
I6J48_RS08310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J48_RS08310	COG0519	Catalyzes the synthesis of GMP from XMP
I6J48_RS08315	COG4399	Belongs to the UPF0754 family
I6J48_RS08320	COG2259	Doxx family
I6J48_RS08325	COG0586	Pfam SNARE associated Golgi protein
I6J48_RS08340	COG1192	Involved in chromosome partitioning
I6J48_RS08350	COG0271	Belongs to the BolA IbaG family
I6J48_RS08385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J48_RS08390	COG0300	oxidoreductase activity
I6J48_RS08390	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS08390	COG3321	synthase
I6J48_RS08390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J48_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS08395	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS08405	COG2197	response regulator
I6J48_RS08415	COG3916	Acyl-homoserine-lactone synthase
I6J48_RS08420	COG0477	Major facilitator Superfamily
I6J48_RS08425	COG1024	Enoyl-CoA hydratase
I6J48_RS08430	COG1024	Enoyl-CoA hydratase
I6J48_RS08435	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS08440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J48_RS08460	COG1113	amino acid transport
I6J48_RS08465	COG1113	amino acid transport
I6J48_RS08470	COG0251	oxidation-reduction process
I6J48_RS08520	COG0564	pseudouridine synthase activity
I6J48_RS08590	COG1051	belongs to the nudix hydrolase family
I6J48_RS08620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J48_RS08635	COG1802	Transcriptional regulator
I6J48_RS08640	COG1448	Aminotransferase
I6J48_RS08645	COG0277	FAD linked oxidase domain protein
I6J48_RS08655	COG2186	Transcriptional regulator
I6J48_RS08665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J48_RS08670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J48_RS08685	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J48_RS08690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J48_RS08705	COG1215	transferase activity, transferring glycosyl groups
I6J48_RS08750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6J48_RS08780	COG0728	peptidoglycan biosynthetic process
I6J48_RS08785	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6J48_RS08845	COG0546	phosphoglycolate phosphatase activity
I6J48_RS08850	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS08865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6J48_RS08865	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J48_RS08870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J48_RS08875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J48_RS08880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS08885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS08890	COG1116	anion transmembrane transporter activity
I6J48_RS08895	COG1309	transcriptional regulator
I6J48_RS08900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J48_RS08910	COG0196	riboflavin kinase activity
I6J48_RS08915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J48_RS08925	COG1047	Peptidyl-prolyl cis-trans
I6J48_RS08965	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J48_RS08970	COG0657	acetylesterase activity
I6J48_RS09020	COG2951	lytic endotransglycosylase activity
I6J48_RS09025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6J48_RS09040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J48_RS09050	COG0671	phosphoesterase, PA-phosphatase related
I6J48_RS09055	COG0861	Integral membrane protein TerC family
I6J48_RS09065	COG0754	glutathionylspermidine amidase activity
I6J48_RS09075	COG0402	S-adenosylhomocysteine deaminase activity
I6J48_RS09090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J48_RS09095	COG1230	cation diffusion facilitator family transporter
I6J48_RS09110	COG0706	membrane insertase activity
I6J48_RS09135	COG0592	DNA-directed DNA polymerase activity
I6J48_RS09145	COG0187	DNA topoisomerase II activity
I6J48_RS09160	COG0488	(ABC) transporter
I6J48_RS09185	COG0596	Alpha beta hydrolase
I6J48_RS09190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6J48_RS09195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J48_RS09240	COG0733	neurotransmitter:sodium symporter activity
I6J48_RS09250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J48_RS09280	COG2233	PERMEase
I6J48_RS09295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS09330	COG2814	Major facilitator Superfamily
I6J48_RS09335	COG0656	L-ascorbic acid biosynthetic process
I6J48_RS09340	COG0583	DNA-binding transcription factor activity
I6J48_RS09355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J48_RS09360	COG1064	alcohol dehydrogenase
I6J48_RS09365	COG2818	Glycosylase
I6J48_RS09380	COG1194	a g-specific adenine glycosylase
I6J48_RS09400	COG2983	Belongs to the UPF0260 family
I6J48_RS09405	COG2133	pyrroloquinoline quinone binding
I6J48_RS09410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J48_RS09415	COG2116	formate transmembrane transporter activity
I6J48_RS09435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J48_RS09440	COG1335	isochorismatase
I6J48_RS09445	COG0385	Bile acid
I6J48_RS09450	COG0534	Mate efflux family protein
I6J48_RS09455	COG1683	Conserved Protein
I6J48_RS09470	COG0346	lactoylglutathione lyase activity
I6J48_RS09475	COG0625	glutathione transferase activity
I6J48_RS09485	COG1113	amino acid transport
I6J48_RS09495	COG0523	cobalamin synthesis protein
I6J48_RS09505	COG2188	Transcriptional regulator
I6J48_RS09535	COG0010	Belongs to the arginase family
I6J48_RS09545	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J48_RS09555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J48_RS09565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J48_RS09570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6J48_RS09635	COG1910	domain protein
I6J48_RS09670	COG0534	Mate efflux family protein
I6J48_RS09675	COG0436	Aminotransferase
I6J48_RS09680	COG2733	membrane
I6J48_RS09695	COG2918	glutathione biosynthetic process
I6J48_RS09710	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J48_RS09710	COG1388	LysM domain
I6J48_RS09750	COG3150	esterase
I6J48_RS09760	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6J48_RS09770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6J48_RS09780	COG2233	PERMEase
I6J48_RS09820	COG3706	GGDEF domain
I6J48_RS09835	COG1393	Belongs to the ArsC family
I6J48_RS09840	COG0708	Exodeoxyribonuclease III
I6J48_RS09860	COG0189	ligase activity
I6J48_RS09880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J48_RS09890	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J48_RS09905	COG4942	peptidase
I6J48_RS09915	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J48_RS09925	COG2119	membrane
I6J48_RS09930	COG4774	siderophore transport
I6J48_RS09935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J48_RS09935	COG0426	domain, Protein
I6J48_RS09955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J48_RS09975	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS09980	COG1519	Transferase
I6J48_RS09985	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J48_RS09990	COG0668	transmembrane transport
I6J48_RS10000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6J48_RS10005	COG1335	isochorismatase
I6J48_RS10010	COG1522	sequence-specific DNA binding
I6J48_RS10035	COG2205	protein histidine kinase activity
I6J48_RS10035	COG2198	Histidine kinase
I6J48_RS10035	COG0784	Response regulator, receiver
I6J48_RS10040	COG3162	membrane
I6J48_RS10045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6J48_RS10055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6J48_RS10075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J48_RS10080	COG1309	transcriptional regulator
I6J48_RS10100	COG4221	oxidoreductase activity
I6J48_RS10105	COG0789	Transcriptional regulator
I6J48_RS10110	COG0351	phosphomethylpyrimidine kinase
I6J48_RS10110	COG0352	thiamine-phosphate diphosphorylase activity
I6J48_RS10110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6J48_RS10120	COG2814	Major facilitator Superfamily
I6J48_RS10125	COG0629	single-stranded DNA binding
I6J48_RS10135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6J48_RS10145	COG1113	amino acid transport
I6J48_RS10155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J48_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS10165	COG1335	isochorismatase
I6J48_RS10170	COG0583	DNA-binding transcription factor activity
I6J48_RS10180	COG1335	isochorismatase
I6J48_RS10220	COG2814	Major facilitator Superfamily
I6J48_RS10225	COG0583	DNA-binding transcription factor activity
I6J48_RS10265	COG0667	Aldo Keto reductase
I6J48_RS10305	COG1733	regulation of RNA biosynthetic process
I6J48_RS10310	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J48_RS10335	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6J48_RS10340	COG2207	Transcriptional regulator
I6J48_RS10395	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6J48_RS10410	COG2329	Antibiotic biosynthesis monooxygenase
I6J48_RS10415	COG0697	spore germination
I6J48_RS10440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J48_RS10470	COG0427	acetyl-CoA hydrolase
I6J48_RS10495	COG0659	secondary active sulfate transmembrane transporter activity
I6J48_RS10500	COG4221	oxidoreductase activity
I6J48_RS10505	COG2873	o-acetylhomoserine
I6J48_RS10510	COG0488	(ABC) transporter
I6J48_RS10575	COG0833	amino acid
I6J48_RS10620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J48_RS10625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J48_RS10640	COG2226	methyltransferase
I6J48_RS10690	COG0069	glutamate synthase activity
I6J48_RS10690	COG0067	glutamate synthase
I6J48_RS10690	COG0070	glutamate synthase
I6J48_RS10695	COG0493	'glutamate synthase
I6J48_RS10705	COG1704	LemA family
I6J48_RS10710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6J48_RS10730	COG3307	-O-antigen
I6J48_RS10750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6J48_RS10765	COG0194	GDP metabolic process
I6J48_RS10815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J48_RS10835	COG5380	lipid catabolic process
I6J48_RS10840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J48_RS10860	COG5006	permease, DMT superfamily
I6J48_RS10865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J48_RS10870	COG0277	FAD linked oxidase domain protein
I6J48_RS10875	COG2131	deaminase
I6J48_RS10890	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6J48_RS10895	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J48_RS10915	COG1289	transmembrane transporter activity
I6J48_RS10925	COG0628	permease
I6J48_RS10930	COG1192	Involved in chromosome partitioning
I6J48_RS10960	COG0833	amino acid
I6J48_RS10965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J48_RS10970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J48_RS10980	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS11020	COG0583	DNA-binding transcription factor activity
I6J48_RS11025	COG1794	racemase activity, acting on amino acids and derivatives
I6J48_RS11030	COG0583	DNA-binding transcription factor activity
I6J48_RS11050	COG0752	glycyl-tRNA synthetase alpha subunit
I6J48_RS11075	COG0517	IMP dehydrogenase activity
I6J48_RS11075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J48_RS11075	COG0617	tRNA 3'-terminal CCA addition
I6J48_RS11080	COG1983	PspC domain protein
I6J48_RS11090	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS11105	COG0408	coproporphyrinogen oxidase activity
I6J48_RS11125	COG0513	Belongs to the DEAD box helicase family
I6J48_RS11135	COG1127	ABC transporter
I6J48_RS11140	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6J48_RS11160	COG0598	Magnesium transport protein CorA
I6J48_RS11170	COG0494	nUDIX hydrolase
I6J48_RS11175	COG1040	competence protein
I6J48_RS11180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J48_RS11195	COG2937	Belongs to the GPAT DAPAT family
I6J48_RS11200	COG1946	Acyl-CoA thioesterase
I6J48_RS11205	COG1301	dicarboxylic acid transport
I6J48_RS11220	COG1959	2 iron, 2 sulfur cluster binding
I6J48_RS11225	COG1017	nitric oxide dioxygenase activity
I6J48_RS11225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J48_RS11230	COG0433	COG0433 Predicted ATPase
I6J48_RS11235	COG0626	cystathionine gamma-synthase activity
I6J48_RS11250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J48_RS11255	COG0088	Forms part of the polypeptide exit tunnel
I6J48_RS11275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J48_RS11315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J48_RS11390	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS11395	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6J48_RS11420	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6J48_RS11425	COG0339	signal peptide processing
I6J48_RS11430	COG0557	exoribonuclease II activity
I6J48_RS11475	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6J48_RS11480	COG1295	ribonuclease BN
I6J48_RS11515	COG1702	phosphate starvation-inducible protein PhoH
I6J48_RS11525	COG0739	heme binding
I6J48_RS11525	COG0741	lytic transglycosylase activity
I6J48_RS11525	COG1196	nuclear chromosome segregation
I6J48_RS11555	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6J48_RS11560	COG1183	phosphatidylcholine synthase activity
I6J48_RS11610	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS11615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J48_RS11620	COG1309	transcriptional regulator
I6J48_RS11635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6J48_RS11640	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS11660	COG2969	positive regulation of protein catabolic process
I6J48_RS11670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J48_RS11675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J48_RS11680	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6J48_RS11685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J48_RS11690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J48_RS11710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J48_RS11720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J48_RS11725	COG1408	metallophosphoesterase
I6J48_RS11730	COG2885	chlorophyll binding
I6J48_RS11735	COG2199	diguanylate cyclase activity
I6J48_RS11770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J48_RS11795	COG1607	acyl-coa hydrolase
I6J48_RS11825	COG2350	Protein conserved in bacteria
I6J48_RS11835	COG0613	PHP domain protein
I6J48_RS11840	COG3781	membrane
I6J48_RS11850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J48_RS11855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6J48_RS11865	COG1862	Preprotein translocase
I6J48_RS11885	COG4999	Histidine kinase
I6J48_RS11885	COG3437	response regulator, receiver
I6J48_RS11885	COG2205	protein histidine kinase activity
I6J48_RS11885	COG3850	Histidine kinase
I6J48_RS11890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6J48_RS11910	COG0726	polysaccharide deacetylase
I6J48_RS11915	COG0463	Glycosyl transferase, family 2
I6J48_RS11920	COG0438	transferase activity, transferring glycosyl groups
I6J48_RS11955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6J48_RS11990	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS11995	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS12005	COG2205	protein histidine kinase activity
I6J48_RS12010	COG0745	RESPONSE REGULATOR receiver
I6J48_RS12020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6J48_RS12040	COG2096	Adenosyltransferase
I6J48_RS12090	COG0285	dihydrofolate synthase activity
I6J48_RS12115	COG0450	alkyl hydroperoxide reductase
I6J48_RS12130	COG0477	Major facilitator Superfamily
I6J48_RS12135	COG1272	protein, Hemolysin III
I6J48_RS12145	COG2153	protein acetylation
I6J48_RS12165	COG0183	Belongs to the thiolase family
I6J48_RS12170	COG2207	Transcriptional regulator
I6J48_RS12190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J48_RS12210	COG0183	Belongs to the thiolase family
I6J48_RS12220	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6J48_RS12220	COG2885	chlorophyll binding
I6J48_RS12230	COG1690	Belongs to the RtcB family
I6J48_RS12235	COG0833	amino acid
I6J48_RS12245	COG2233	PERMEase
I6J48_RS12250	COG1217	gtp-binding protein TYPA
I6J48_RS12275	COG2094	Belongs to the DNA glycosylase MPG family
I6J48_RS12280	COG4772	TonB-dependent receptor
I6J48_RS12285	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS12290	COG0679	Auxin Efflux Carrier
I6J48_RS12300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6J48_RS12305	COG0354	folic acid binding
I6J48_RS12325	COG2233	PERMEase
I6J48_RS12330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J48_RS12335	COG0251	oxidation-reduction process
I6J48_RS12340	COG1335	isochorismatase
I6J48_RS12345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS12350	COG0778	Nitroreductase
I6J48_RS12355	COG0596	Alpha beta hydrolase
I6J48_RS12360	COG3189	MarR family transcriptional regulator
I6J48_RS12365	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J48_RS12370	COG3422	double-strand break repair
I6J48_RS12410	COG0840	transmembrane signaling receptor activity
I6J48_RS12440	COG2832	Protein of unknown function (DUF454)
I6J48_RS12445	COG1376	ErfK ybiS ycfS ynhG family protein
I6J48_RS12485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6J48_RS12495	COG1289	transmembrane transporter activity
I6J48_RS12500	COG2814	Major facilitator Superfamily
I6J48_RS12520	COG1115	amino acid carrier protein
I6J48_RS12525	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J48_RS12530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J48_RS12535	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6J48_RS12575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J48_RS12585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J48_RS12590	COG1077	Cell shape determining protein MreB Mrl
I6J48_RS12595	COG1792	Involved in formation and maintenance of cell shape
I6J48_RS12600	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6J48_RS12605	COG0424	maF-like protein
I6J48_RS12610	COG1530	ribonuclease E activity
I6J48_RS12620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J48_RS12640	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J48_RS12725	COG1113	amino acid transport
I6J48_RS12730	COG2828	Protein conserved in bacteria
I6J48_RS12735	COG0142	geranyltranstransferase activity
I6J48_RS12740	COG2315	Protein conserved in bacteria
I6J48_RS12755	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6J48_RS12780	COG2194	sulfuric ester hydrolase activity
I6J48_RS12785	COG0745	RESPONSE REGULATOR receiver
I6J48_RS12790	COG0642	Histidine kinase
I6J48_RS12800	COG0004	ammonium transporteR
I6J48_RS12805	COG0583	DNA-binding transcription factor activity
I6J48_RS12835	COG0525	valine-tRNA ligase activity
I6J48_RS12845	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS12850	COG2223	nitrite transmembrane transporter activity
I6J48_RS12855	COG0393	Putative heavy-metal-binding
I6J48_RS12860	COG0393	Putative heavy-metal-binding
I6J48_RS12865	COG1538	Outer membrane efflux protein
I6J48_RS12875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS12880	COG0671	phosphoesterase, PA-phosphatase related
I6J48_RS12905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6J48_RS12920	COG1648	precorrin-2 dehydrogenase activity
I6J48_RS12920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6J48_RS12925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6J48_RS12960	COG0531	amino acid
I6J48_RS12975	COG0321	lipoyl(octanoyl) transferase activity
I6J48_RS12980	COG2921	Belongs to the UPF0250 family
I6J48_RS13015	COG2009	succinate dehydrogenase
I6J48_RS13020	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6J48_RS13025	COG1053	succinate dehydrogenase
I6J48_RS13030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6J48_RS13055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J48_RS13075	COG2354	Protein conserved in bacteria
I6J48_RS13080	COG2321	neutral zinc metallopeptidase
I6J48_RS13100	COG2843	Capsule synthesis protein
I6J48_RS13115	COG0589	response to stress
I6J48_RS13135	COG0505	Belongs to the CarA family
I6J48_RS13155	COG1534	Rna-binding protein
I6J48_RS13165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J48_RS13170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6J48_RS13190	COG3540	Alkaline phosphatase
I6J48_RS13220	COG0477	Major facilitator Superfamily
I6J48_RS13225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6J48_RS13240	COG1597	lipid kinase activity
I6J48_RS13245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6J48_RS13270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J48_RS13275	COG0584	glycerophosphoryl diester phosphodiesterase
I6J48_RS13295	COG0741	lytic transglycosylase activity
I6J48_RS13310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
I6J48_RS13315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6J48_RS13335	COG0583	DNA-binding transcription factor activity
I6J48_RS13340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J48_RS13390	COG2207	Transcriptional regulator
I6J48_RS13405	COG0778	Nitroreductase
I6J48_RS13420	COG1929	Belongs to the glycerate kinase type-1 family
I6J48_RS13450	COG1113	amino acid transport
I6J48_RS13460	COG0019	diaminopimelate decarboxylase activity
I6J48_RS13470	COG2267	carboxylic ester hydrolase activity
I6J48_RS13475	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS13480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6J48_RS13505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J48_RS13525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS13555	COG0697	spore germination
I6J48_RS13560	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J48_RS13565	COG1136	(ABC) transporter
I6J48_RS13570	COG2333	competence protein COMEC
I6J48_RS13570	COG0658	competence protein
I6J48_RS13580	COG0616	signal peptide processing
I6J48_RS13580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6J48_RS13590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J48_RS13600	COG0628	permease
I6J48_RS13635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J48_RS13655	COG0823	Involved in the tonB-independent uptake of proteins
I6J48_RS13675	COG0824	Thioesterase
I6J48_RS13680	COG1473	amidohydrolase
I6J48_RS13700	COG0047	phosphoribosylformylglycinamidine synthase activity
I6J48_RS13700	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J48_RS13705	COG2814	Major facilitator Superfamily
I6J48_RS13710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J48_RS13715	COG1024	Enoyl-CoA hydratase
I6J48_RS13720	COG1056	cytidyltransferase-related domain
I6J48_RS13720	COG1051	belongs to the nudix hydrolase family
I6J48_RS13735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6J48_RS13750	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6J48_RS13755	COG0602	queuosine metabolic process
I6J48_RS13765	COG4625	pathogenesis
I6J48_RS13770	COG0583	DNA-binding transcription factor activity
I6J48_RS13775	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J48_RS13780	COG4208	sulfate ABC transporter
I6J48_RS13785	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6J48_RS13795	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6J48_RS13800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J48_RS13805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J48_RS13825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J48_RS13835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J48_RS13840	COG0481	GTPase activity
I6J48_RS13845	COG0681	Belongs to the peptidase S26 family
I6J48_RS13855	COG0571	ribonuclease III activity
I6J48_RS13860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J48_RS13875	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6J48_RS13885	COG4221	oxidoreductase activity
I6J48_RS13915	COG0436	Aminotransferase
I6J48_RS13935	COG0556	nucleotide-excision repair
I6J48_RS13990	COG2070	2-Nitropropane dioxygenase
I6J48_RS14020	COG1215	transferase activity, transferring glycosyl groups
I6J48_RS14035	COG0415	Belongs to the DNA photolyase family
I6J48_RS14045	COG1252	NADH dehydrogenase
I6J48_RS14050	COG1686	Belongs to the peptidase S11 family
I6J48_RS14065	COG1187	pseudouridine synthase activity
I6J48_RS14080	COG0477	Major facilitator Superfamily
I6J48_RS14085	COG0583	DNA-binding transcription factor activity
I6J48_RS14090	COG1823	symporter activity
I6J48_RS14100	COG0612	Peptidase, M16
I6J48_RS14125	COG0352	thiamine-phosphate diphosphorylase activity
I6J48_RS14160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6J48_RS14185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6J48_RS14190	COG0076	glutamate decarboxylase activity
I6J48_RS14200	COG1522	sequence-specific DNA binding
I6J48_RS14205	COG3961	Belongs to the TPP enzyme family
I6J48_RS14210	COG1113	amino acid transport
I6J48_RS14215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J48_RS14220	COG0573	inorganic phosphate transmembrane transporter activity
I6J48_RS14230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J48_RS14235	COG0616	signal peptide processing
I6J48_RS14270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6J48_RS14275	COG1686	Belongs to the peptidase S11 family
I6J48_RS14295	COG4942	peptidase
I6J48_RS14295	COG1388	LysM domain
I6J48_RS14300	COG0583	DNA-binding transcription factor activity
I6J48_RS14305	COG1067	ATP-dependent peptidase activity
I6J48_RS14325	COG0254	rRNA binding
I6J48_RS14345	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J48_RS14350	COG1966	Carbon starvation protein
I6J48_RS14355	COG2879	small protein
I6J48_RS14365	COG0673	inositol 2-dehydrogenase activity
I6J48_RS14375	COG0583	DNA-binding transcription factor activity
I6J48_RS14380	COG3485	protocatechuate 3,4-dioxygenase
I6J48_RS14385	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J48_RS14390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J48_RS14395	COG0183	Belongs to the thiolase family
I6J48_RS14405	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS14425	COG0673	inositol 2-dehydrogenase activity
I6J48_RS14430	COG0738	Major facilitator superfamily
I6J48_RS14440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS14445	COG0583	DNA-binding transcription factor activity
I6J48_RS14470	COG2423	ornithine cyclodeaminase activity
I6J48_RS14480	COG2964	Protein conserved in bacteria
I6J48_RS14490	COG1741	Belongs to the pirin family
I6J48_RS14505	COG3739	integral membrane protein
I6J48_RS14525	COG0302	gtp cyclohydrolase
I6J48_RS14535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6J48_RS14570	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J48_RS14585	COG0174	glutamine synthetase
I6J48_RS14595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6J48_RS14630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J48_RS14635	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J48_RS14640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J48_RS14650	COG0280	phosphate acetyltransferase
I6J48_RS14650	COG0281	malic enzyme
I6J48_RS14660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J48_RS14665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J48_RS14670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6J48_RS14685	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS14690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6J48_RS14695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J48_RS14705	COG2223	nitrite transmembrane transporter activity
I6J48_RS14715	COG0024	Methionine aminopeptidase
I6J48_RS14720	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J48_RS14760	COG2951	lytic endotransglycosylase activity
I6J48_RS14765	COG0772	Belongs to the SEDS family
I6J48_RS14780	COG0842	Transport permease protein
I6J48_RS14785	COG1131	(ABC) transporter
I6J48_RS14830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS14850	COG4160	amino acid transport
I6J48_RS14855	COG4598	ABC transporter
I6J48_RS14865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J48_RS14870	COG0384	phenazine biosynthesis protein PhzF
I6J48_RS14880	COG1720	tRNA m6t6A37 methyltransferase activity
I6J48_RS14890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J48_RS14905	COG0642	Histidine kinase
I6J48_RS14915	COG0494	nUDIX hydrolase
I6J48_RS14925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J48_RS14930	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6J48_RS14935	COG3139	Protein of unknown function (DUF1315)
I6J48_RS14945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6J48_RS14950	COG1301	dicarboxylic acid transport
I6J48_RS14955	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS14965	COG2819	hydrolase of the alpha beta superfamily
I6J48_RS14975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J48_RS14985	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J48_RS14990	COG1234	tRNA 3'-trailer cleavage
I6J48_RS15020	COG2363	Small membrane protein
I6J48_RS15040	COG0513	Belongs to the DEAD box helicase family
I6J48_RS15050	COG0778	Nitroreductase
I6J48_RS15080	COG1286	toxin biosynthetic process
I6J48_RS15110	COG1610	YqeY-like protein
I6J48_RS15165	COG1278	Cold shock
I6J48_RS15190	COG0534	Mate efflux family protein
I6J48_RS15215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6J48_RS15220	COG4221	oxidoreductase activity
I6J48_RS15225	COG1733	regulation of RNA biosynthetic process
I6J48_RS15230	COG2085	NADP oxidoreductase coenzyme F420-dependent
I6J48_RS15260	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6J48_RS15265	COG0786	glutamate:sodium symporter activity
I6J48_RS15270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J48_RS15270	COG0475	glutathione-regulated potassium exporter activity
I6J48_RS15285	COG0477	Major facilitator Superfamily
I6J48_RS15305	COG0583	DNA-binding transcription factor activity
I6J48_RS15315	COG2995	paraquat-inducible protein a
I6J48_RS15320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6J48_RS15320	COG3008	intermembrane lipid transfer
I6J48_RS15330	COG2351	hydroxyisourate hydrolase activity
I6J48_RS15355	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J48_RS15360	COG1794	racemase activity, acting on amino acids and derivatives
I6J48_RS15370	COG2175	clavaminate synthase activity
I6J48_RS15375	COG3246	L-lysine catabolic process to acetate
I6J48_RS15395	COG2855	membrane
I6J48_RS15430	COG2814	Major facilitator Superfamily
I6J48_RS15445	COG0625	glutathione transferase activity
I6J48_RS15460	COG1301	dicarboxylic acid transport
I6J48_RS15475	COG2011	ABC-type metal ion transport system permease component
I6J48_RS15480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J48_RS15490	COG0151	Belongs to the GarS family
I6J48_RS15495	COG0138	bifunctional purine biosynthesis protein purh
I6J48_RS15500	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6J48_RS15530	COG2308	Evidence 4 Homologs of previously reported genes of
I6J48_RS15540	COG1305	Transglutaminase-like
I6J48_RS15550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J48_RS15555	COG0305	Participates in initiation and elongation during chromosome replication
I6J48_RS15580	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6J48_RS15590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6J48_RS15620	COG0726	polysaccharide deacetylase
I6J48_RS15620	COG1649	PFAM Uncharacterised BCR, COG1649
I6J48_RS15625	COG1215	transferase activity, transferring glycosyl groups
I6J48_RS15630	COG3658	cytochrome
I6J48_RS15640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS15655	COG0583	DNA-binding transcription factor activity
I6J48_RS15675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS15680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J48_RS15695	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS15700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J48_RS15715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6J48_RS15725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6J48_RS15730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6J48_RS15740	COG2205	protein histidine kinase activity
I6J48_RS15745	COG0745	RESPONSE REGULATOR receiver
I6J48_RS15750	COG0174	glutamine synthetase
I6J48_RS15770	COG0729	surface antigen
I6J48_RS15800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J48_RS15805	COG2814	Major facilitator Superfamily
I6J48_RS15820	COG0583	DNA-binding transcription factor activity
I6J48_RS15835	COG1187	pseudouridine synthase activity
I6J48_RS15855	COG0802	atpase or kinase
I6J48_RS15860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J48_RS15870	COG1923	regulation of RNA biosynthetic process
I6J48_RS15875	COG0697	spore germination
I6J48_RS15900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J48_RS15905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J48_RS15905	COG0519	Catalyzes the synthesis of GMP from XMP
I6J48_RS15910	COG4302	ethanolamine ammonia-lyase activity
I6J48_RS15915	COG4303	Ethanolamine ammonia lyase large subunit
I6J48_RS15920	COG0531	amino acid
I6J48_RS15940	COG1454	alcohol dehydrogenase
I6J48_RS15945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J48_RS15955	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6J48_RS15975	COG0308	aminopeptidase N
I6J48_RS16015	COG1605	Chorismate mutase
I6J48_RS16020	COG1280	lysine exporter protein (LysE YggA)
I6J48_RS16045	COG4772	TonB-dependent receptor
I6J48_RS16050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J48_RS16060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J48_RS16100	COG1733	regulation of RNA biosynthetic process
I6J48_RS16120	COG0583	DNA-binding transcription factor activity
I6J48_RS16135	COG3111	PFAM Bacterial OB fold (BOF) protein
I6J48_RS16155	COG0488	(ABC) transporter
I6J48_RS16160	COG0589	response to stress
I6J48_RS16180	COG3135	benzoate transporter
I6J48_RS16185	COG1522	sequence-specific DNA binding
I6J48_RS16195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J48_RS16200	COG0583	DNA-binding transcription factor activity
I6J48_RS16210	COG0183	Belongs to the thiolase family
I6J48_RS16220	COG2030	dehydratase
I6J48_RS16250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J48_RS16260	COG0824	Thioesterase
I6J48_RS16265	COG1454	alcohol dehydrogenase
I6J48_RS16280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J48_RS16310	COG0069	glutamate synthase activity
I6J48_RS16340	COG2814	Major facilitator Superfamily
I6J48_RS16355	COG0511	ligase activity, forming carbon-carbon bonds
I6J48_RS16390	COG2814	Major facilitator Superfamily
I6J48_RS16395	COG4264	IucA IucC family
I6J48_RS16400	COG4264	IucA IucC family
I6J48_RS16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J48_RS16435	COG1116	anion transmembrane transporter activity
I6J48_RS16450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J48_RS16450	COG2146	nitrite reductase [NAD(P)H] activity
I6J48_RS16455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6J48_RS16460	COG0243	molybdopterin cofactor binding
I6J48_RS16470	COG0243	molybdopterin cofactor binding
I6J48_RS16490	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6J48_RS16490	COG0315	cyclic pyranopterin monophosphate synthase activity
I6J48_RS16495	COG0303	'Molybdopterin
I6J48_RS16505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J48_RS16510	COG0697	spore germination
I6J48_RS16535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J48_RS16555	COG1335	isochorismatase
I6J48_RS16595	COG2204	response regulator
I6J48_RS16600	COG3852	Histidine kinase
I6J48_RS16625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J48_RS16630	COG0575	Belongs to the CDS family
I6J48_RS16645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6J48_RS16665	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6J48_RS16680	COG2137	regulation of response to DNA damage stimulus
I6J48_RS16690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J48_RS16695	COG1011	Hydrolase
I6J48_RS16710	COG1522	sequence-specific DNA binding
I6J48_RS16720	COG1113	amino acid transport
I6J48_RS16740	COG0659	secondary active sulfate transmembrane transporter activity
I6J48_RS16755	COG5001	Diguanylate cyclase
I6J48_RS16755	COG3300	MHYT domain
I6J48_RS16775	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6J48_RS16775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J48_RS16775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J48_RS16780	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J48_RS16785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J48_RS16785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J48_RS16815	COG0024	Methionine aminopeptidase
I6J48_RS16820	COG0583	DNA-binding transcription factor activity
I6J48_RS16835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J48_RS16840	COG0517	IMP dehydrogenase activity
I6J48_RS16840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6J48_RS16865	COG0552	protein localization to endoplasmic reticulum
I6J48_RS16875	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I6J48_RS16885	COG4890	Cyd operon protein YbgT
I6J48_RS16890	COG1294	oxidase, subunit
I6J48_RS16905	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6J48_RS16915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J48_RS16920	COG4774	siderophore transport
I6J48_RS16935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J48_RS16940	COG0569	domain protein
I6J48_RS16945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J48_RS16975	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6J48_RS16980	COG0542	response to heat
I6J48_RS16990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J48_RS17005	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS17005	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J48_RS17045	COG0148	phosphopyruvate hydratase activity
I6J48_RS17050	COG2323	membrane
I6J48_RS17065	COG4773	Receptor
I6J48_RS17070	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6J48_RS17080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J48_RS17085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J48_RS17090	COG0183	Belongs to the thiolase family
I6J48_RS17095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J48_RS17100	COG0596	Alpha beta hydrolase
I6J48_RS17105	COG2271	Major facilitator Superfamily
I6J48_RS17110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J48_RS17115	COG3485	protocatechuate 3,4-dioxygenase
I6J48_RS17120	COG3485	protocatechuate 3,4-dioxygenase
I6J48_RS17125	COG0710	3-dehydroquinate dehydratase activity
I6J48_RS17130	COG3420	alginic acid biosynthetic process
I6J48_RS17135	COG3659	wide pore channel activity
I6J48_RS17140	COG4993	Dehydrogenase
I6J48_RS17165	COG1414	Transcriptional regulator
I6J48_RS17170	COG0583	DNA-binding transcription factor activity
I6J48_RS17175	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS17200	COG2814	Major facilitator Superfamily
I6J48_RS17210	COG0154	amidase activity
I6J48_RS17240	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6J48_RS17260	COG3733	amine oxidase
I6J48_RS17270	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS17280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6J48_RS17285	COG0183	Belongs to the thiolase family
I6J48_RS17290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J48_RS17295	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J48_RS17305	COG4829	muconolactone delta-isomerase
I6J48_RS17310	COG4948	Mandelate Racemase Muconate Lactonizing
I6J48_RS17315	COG0583	DNA-binding transcription factor activity
I6J48_RS17325	COG2186	Transcriptional regulator
I6J48_RS17345	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS17375	COG1309	transcriptional regulator
I6J48_RS17395	COG0604	alcohol dehydrogenase
I6J48_RS17395	COG3321	synthase
I6J48_RS17400	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17420	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS17445	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS17455	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17465	COG0300	oxidoreductase activity
I6J48_RS17475	COG1733	regulation of RNA biosynthetic process
I6J48_RS17480	COG0702	epimerase
I6J48_RS17485	COG1012	belongs to the aldehyde dehydrogenase family
I6J48_RS17490	COG0129	dihydroxy-acid dehydratase activity
I6J48_RS17500	COG0583	DNA-binding transcription factor activity
I6J48_RS17505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J48_RS17515	COG2084	Dehydrogenase
I6J48_RS17530	COG4689	acetoacetate decarboxylase
I6J48_RS17540	COG1902	pentaerythritol trinitrate reductase activity
I6J48_RS17550	COG0583	DNA-binding transcription factor activity
I6J48_RS17565	COG1309	transcriptional regulator
I6J48_RS17575	COG3956	TIGRFAM MazG family protein
I6J48_RS17595	COG0583	DNA-binding transcription factor activity
I6J48_RS17610	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17615	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17620	COG1028	Short-chain dehydrogenase reductase Sdr
I6J48_RS17630	COG1960	acyl-CoA dehydrogenase activity
I6J48_RS17640	COG0318	PFAM AMP-dependent synthetase and ligase
I6J48_RS17680	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
I6J48_RS17705	COG2831	hemolysin activation secretion protein
I6J48_RS17745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6J48_RS17750	COG3119	arylsulfatase activity
I6J48_RS17760	COG1566	PFAM secretion protein HlyD family protein
I6J48_RS17785	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6J48_RS17810	COG2207	Transcriptional regulator
I6J48_RS17825	COG1064	alcohol dehydrogenase
I6J48_RS17845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J48_RS17850	COG1120	ATPase activity
I6J48_RS17870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J48_RS18010	COG4628	conserved protein (DUF2132)
I6J48_RS18015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS18050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J48_RS18055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6J48_RS18060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS18065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6J48_RS18080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6J48_RS18115	COG1132	(ABC) transporter
I6J48_RS18120	COG1132	(ABC) transporter
I6J48_RS18140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J48_RS18145	COG0601	transmembrane transport
I6J48_RS18175	COG3539	Fimbrial protein
I6J48_RS18200	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6J48_RS18210	COG0753	catalase activity
I6J48_RS18230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J48_RS18240	COG2205	protein histidine kinase activity
I6J48_RS18245	COG0745	RESPONSE REGULATOR receiver
I6J48_RS18250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J48_RS18255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family