locus-tag	class	description
C9E88_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9E88_RS00010	COG0592	DNA-directed DNA polymerase activity
C9E88_RS00020	COG0187	DNA topoisomerase II activity
C9E88_RS00030	COG0488	(ABC) transporter
C9E88_RS00085	COG0657	acetylesterase activity
C9E88_RS00095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C9E88_RS00125	COG0733	neurotransmitter:sodium symporter activity
C9E88_RS00180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C9E88_RS00255	COG1309	transcriptional regulator
C9E88_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS00280	COG3307	-O-antigen
C9E88_RS00285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C9E88_RS00305	COG1064	alcohol dehydrogenase
C9E88_RS00310	COG2818	Glycosylase
C9E88_RS00320	COG0739	heme binding
C9E88_RS00325	COG1194	a g-specific adenine glycosylase
C9E88_RS00365	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C9E88_RS00380	COG0110	maltose O-acetyltransferase activity
C9E88_RS00390	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS00395	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS00400	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS00405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C9E88_RS00415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C9E88_RS00425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C9E88_RS00435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9E88_RS00465	COG0110	maltose O-acetyltransferase activity
C9E88_RS00470	COG0297	glycogen (starch) synthase activity
C9E88_RS00475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C9E88_RS00475	COG0662	Cupin 2, conserved barrel domain protein
C9E88_RS00485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C9E88_RS00490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C9E88_RS00500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C9E88_RS00505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9E88_RS00510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C9E88_RS00515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9E88_RS00520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C9E88_RS00525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C9E88_RS00530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C9E88_RS00545	COG1309	transcriptional regulator
C9E88_RS00585	COG4716	Myosin-crossreactive antigen
C9E88_RS00595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C9E88_RS00595	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C9E88_RS00600	COG1105	Belongs to the carbohydrate kinase PfkB family
C9E88_RS00605	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C9E88_RS00605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9E88_RS00605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C9E88_RS00620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C9E88_RS00625	COG3550	peptidyl-serine autophosphorylation
C9E88_RS00670	COG1454	alcohol dehydrogenase
C9E88_RS00685	COG2801	Transposase and inactivated derivatives
C9E88_RS00690	COG2801	Transposase and inactivated derivatives
C9E88_RS00750	COG1192	Involved in chromosome partitioning
C9E88_RS00765	COG0586	Pfam SNARE associated Golgi protein
C9E88_RS00770	COG2259	Doxx family
C9E88_RS00780	COG0519	Catalyzes the synthesis of GMP from XMP
C9E88_RS00780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9E88_RS00785	COG1401	restriction endodeoxyribonuclease activity
C9E88_RS00800	COG3706	GGDEF domain
C9E88_RS00865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_RS00870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_RS00885	COG0534	Mate efflux family protein
C9E88_RS00890	COG0436	Aminotransferase
C9E88_RS00930	COG2837	iron assimilation
C9E88_RS00945	COG2318	DinB family
C9E88_RS00950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C9E88_RS00955	COG1121	(ABC) transporter
C9E88_RS00995	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C9E88_RS01005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C9E88_RS01050	COG0386	Belongs to the glutathione peroxidase family
C9E88_RS01070	COG0758	DNA mediated transformation
C9E88_RS01105	COG1309	transcriptional regulator
C9E88_RS01155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9E88_RS01165	COG2814	Major facilitator Superfamily
C9E88_RS01180	COG1253	flavin adenine dinucleotide binding
C9E88_RS01190	COG2860	membrane
C9E88_RS01195	COG0477	Major facilitator Superfamily
C9E88_RS01205	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_RS01220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C9E88_RS01240	COG0606	chelatase, subunit chli
C9E88_RS01250	COG0347	Belongs to the P(II) protein family
C9E88_RS01255	COG0004	ammonium transporteR
C9E88_RS01265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9E88_RS01265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C9E88_RS01280	COG0586	Pfam SNARE associated Golgi protein
C9E88_RS01305	COG0795	lipopolysaccharide-transporting ATPase activity
C9E88_RS01310	COG0795	lipopolysaccharide-transporting ATPase activity
C9E88_RS01315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C9E88_RS01320	COG0793	Belongs to the peptidase S41A family
C9E88_RS01335	COG2197	response regulator
C9E88_RS01340	COG1686	Belongs to the peptidase S11 family
C9E88_RS01345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C9E88_RS01355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C9E88_RS01360	COG4974	Belongs to the 'phage' integrase family
C9E88_RS01385	COG0772	Belongs to the SEDS family
C9E88_RS01390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_RS01395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C9E88_RS01400	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C9E88_RS01405	COG0494	nUDIX hydrolase
C9E88_RS01425	COG0704	Plays a role in the regulation of phosphate uptake
C9E88_RS01440	COG1289	transmembrane transporter activity
C9E88_RS01455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C9E88_RS01465	COG0497	DNA recombination
C9E88_RS01470	COG3123	guanosine phosphorylase activity
C9E88_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9E88_RS01485	COG0237	dephospho-CoA kinase activity
C9E88_RS01540	COG0195	Participates in both transcription termination and antitermination
C9E88_RS01550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C9E88_RS01555	COG1320	monovalent cation:proton antiporter activity
C9E88_RS01560	COG2212	antiporter activity
C9E88_RS01565	COG1863	multisubunit Na H antiporter MnhE subunit
C9E88_RS01570	COG0651	ATP synthesis coupled electron transport
C9E88_RS01575	COG1006	Multisubunit Na H antiporter MnhC subunit
C9E88_RS01580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C9E88_RS01580	COG2111	Na H antiporter
C9E88_RS01595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C9E88_RS01600	COG4221	oxidoreductase activity
C9E88_RS01605	COG2873	o-acetylhomoserine
C9E88_RS01610	COG0488	(ABC) transporter
C9E88_RS01630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_RS01640	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_RS01665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C9E88_RS01670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C9E88_RS01675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C9E88_RS01680	COG2226	methyltransferase
C9E88_RS01730	COG0069	glutamate synthase activity
C9E88_RS01730	COG0067	glutamate synthase
C9E88_RS01730	COG0070	glutamate synthase
C9E88_RS01735	COG0493	'glutamate synthase
C9E88_RS01745	COG1704	LemA family
C9E88_RS01750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C9E88_RS01775	COG1132	(ABC) transporter
C9E88_RS01800	COG0463	Glycosyl transferase, family 2
C9E88_RS01800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C9E88_RS01815	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS01840	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9E88_RS01845	COG1758	RNA polymerase activity
C9E88_RS01850	COG0194	GDP metabolic process
C9E88_RS01860	COG4969	Belongs to the N-Me-Phe pilin family
C9E88_RS01895	COG0228	four-way junction DNA binding
C9E88_RS01900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C9E88_RS01910	COG0335	large ribosomal subunit rRNA binding
C9E88_RS01925	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C9E88_RS01930	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C9E88_RS01935	COG5380	lipid catabolic process
C9E88_RS01940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C9E88_RS01965	COG5006	permease, DMT superfamily
C9E88_RS01970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C9E88_RS01975	COG0277	FAD linked oxidase domain protein
C9E88_RS02000	COG2814	Major facilitator Superfamily
C9E88_RS02005	COG1289	transmembrane transporter activity
C9E88_RS02020	COG0628	permease
C9E88_RS02025	COG1192	Involved in chromosome partitioning
C9E88_RS02040	COG2226	methyltransferase
C9E88_RS02060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C9E88_RS02065	COG0254	rRNA binding
C9E88_RS02070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9E88_RS02080	COG0534	Mate efflux family protein
C9E88_RS02090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9E88_RS02095	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS02110	COG0408	coproporphyrinogen oxidase activity
C9E88_RS02115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C9E88_RS02125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C9E88_RS02140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C9E88_RS02150	COG1127	ABC transporter
C9E88_RS02155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C9E88_RS02175	COG0598	Magnesium transport protein CorA
C9E88_RS02185	COG0494	nUDIX hydrolase
C9E88_RS02190	COG1040	competence protein
C9E88_RS02195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C9E88_RS02210	COG2937	Belongs to the GPAT DAPAT family
C9E88_RS02215	COG1946	Acyl-CoA thioesterase
C9E88_RS02220	COG1301	dicarboxylic acid transport
C9E88_RS02235	COG1959	2 iron, 2 sulfur cluster binding
C9E88_RS02245	COG0433	COG0433 Predicted ATPase
C9E88_RS02250	COG0626	cystathionine gamma-synthase activity
C9E88_RS02260	COG0051	transcription antitermination factor activity, RNA binding
C9E88_RS02265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C9E88_RS02270	COG0088	Forms part of the polypeptide exit tunnel
C9E88_RS02285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C9E88_RS02300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C9E88_RS02335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C9E88_RS02340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C9E88_RS02350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C9E88_RS02400	COG2072	flavoprotein involved in K transport
C9E88_RS02410	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS02415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C9E88_RS02450	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C9E88_RS02455	COG0339	signal peptide processing
C9E88_RS02470	COG0557	exoribonuclease II activity
C9E88_RS02505	COG0179	Fumarylacetoacetate (FAA) hydrolase
C9E88_RS02515	COG0697	spore germination
C9E88_RS02525	COG1295	ribonuclease BN
C9E88_RS02545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_RS02585	COG1702	phosphate starvation-inducible protein PhoH
C9E88_RS02590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C9E88_RS02595	COG1196	nuclear chromosome segregation
C9E88_RS02595	COG0741	lytic transglycosylase activity
C9E88_RS02595	COG0739	heme binding
C9E88_RS02630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C9E88_RS02635	COG1183	phosphatidylcholine synthase activity
C9E88_RS02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9E88_RS02695	COG1607	acyl-coa hydrolase
C9E88_RS02730	COG2350	Protein conserved in bacteria
C9E88_RS02745	COG3781	membrane
C9E88_RS02750	COG2003	Belongs to the UPF0758 family
C9E88_RS02755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C9E88_RS02760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9E88_RS02815	COG1968	undecaprenyl-diphosphatase activity
C9E88_RS02820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C9E88_RS02825	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C9E88_RS02835	COG2205	protein histidine kinase activity
C9E88_RS02840	COG0745	RESPONSE REGULATOR receiver
C9E88_RS02845	COG0174	glutamine synthetase
C9E88_RS02865	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C9E88_RS02875	COG0732	type I restriction modification DNA specificity domain
C9E88_RS02890	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C9E88_RS02915	COG2814	Major facilitator Superfamily
C9E88_RS02930	COG0697	spore germination
C9E88_RS02960	COG3622	Belongs to the hyi family
C9E88_RS02965	COG2084	Dehydrogenase
C9E88_RS02970	COG1024	Enoyl-CoA hydratase
C9E88_RS02975	COG0784	Response regulator, receiver
C9E88_RS02975	COG2205	protein histidine kinase activity
C9E88_RS02975	COG5002	protein histidine kinase activity
C9E88_RS02995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C9E88_RS03015	COG1862	Preprotein translocase
C9E88_RS03030	COG1704	LemA family
C9E88_RS03040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C9E88_RS03065	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C9E88_RS03085	COG0726	polysaccharide deacetylase
C9E88_RS03090	COG0463	Glycosyl transferase, family 2
C9E88_RS03095	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS03125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C9E88_RS03155	COG3223	Belongs to the PsiE family
C9E88_RS03175	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS03180	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS03190	COG2205	protein histidine kinase activity
C9E88_RS03195	COG0745	RESPONSE REGULATOR receiver
C9E88_RS03200	COG1113	amino acid transport
C9E88_RS03230	COG2096	Adenosyltransferase
C9E88_RS03235	COG4206	TonB-dependent receptor
C9E88_RS03300	COG0285	dihydrofolate synthase activity
C9E88_RS03320	COG0450	alkyl hydroperoxide reductase
C9E88_RS03335	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C9E88_RS03340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C9E88_RS03365	COG1360	Flagellar Motor Protein
C9E88_RS03370	COG5001	Diguanylate cyclase
C9E88_RS03430	COG2969	positive regulation of protein catabolic process
C9E88_RS03435	COG0625	glutathione transferase activity
C9E88_RS03450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C9E88_RS03455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C9E88_RS03460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C9E88_RS03465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C9E88_RS03470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C9E88_RS03505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C9E88_RS03515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9E88_RS03520	COG1408	metallophosphoesterase
C9E88_RS03530	COG0477	Major facilitator Superfamily
C9E88_RS03535	COG1272	protein, Hemolysin III
C9E88_RS03565	COG1024	Enoyl-CoA hydratase
C9E88_RS03565	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9E88_RS03570	COG0183	Belongs to the thiolase family
C9E88_RS03580	COG2207	Transcriptional regulator
C9E88_RS03585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C9E88_RS03590	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_RS03600	COG3384	dioxygenase
C9E88_RS03610	COG0183	Belongs to the thiolase family
C9E88_RS03630	COG0833	amino acid
C9E88_RS03640	COG2233	PERMEase
C9E88_RS03645	COG1217	gtp-binding protein TYPA
C9E88_RS03660	COG0531	amino acid
C9E88_RS03665	COG4303	Ethanolamine ammonia lyase large subunit
C9E88_RS03670	COG4302	ethanolamine ammonia-lyase activity
C9E88_RS03675	COG0668	transmembrane transport
C9E88_RS03685	COG2081	HI0933 family
C9E88_RS03745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_RS03745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_RS03750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_RS03795	COG0354	folic acid binding
C9E88_RS03845	COG0564	pseudouridine synthase activity
C9E88_RS03860	COG2824	Alkylphosphonate utilization operon protein PhnA
C9E88_RS03870	COG3422	double-strand break repair
C9E88_RS03885	COG0628	permease
C9E88_RS03890	COG5342	invasion associated locus B
C9E88_RS03895	COG0351	phosphomethylpyrimidine kinase
C9E88_RS03895	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C9E88_RS03895	COG0352	thiamine-phosphate diphosphorylase activity
C9E88_RS03925	COG4772	TonB-dependent receptor
C9E88_RS03935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9E88_RS03940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C9E88_RS03940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C9E88_RS03945	COG0745	RESPONSE REGULATOR receiver
C9E88_RS03950	COG2205	protein histidine kinase activity
C9E88_RS03960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_RS03970	COG0649	NAD binding
C9E88_RS03970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_RS03980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C9E88_RS03995	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_RS04000	COG0839	Belongs to the complex I subunit 6 family
C9E88_RS04005	COG0713	ATP synthesis coupled electron transport
C9E88_RS04010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C9E88_RS04015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C9E88_RS04035	COG0210	DNA helicase
C9E88_RS04050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C9E88_RS04060	COG0121	glutamine amidotransferase
C9E88_RS04075	COG2914	Belongs to the UPF0125 (RnfH) family
C9E88_RS04080	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_RS04085	COG0735	belongs to the Fur family
C9E88_RS04110	COG0420	3'-5' exonuclease activity
C9E88_RS04145	COG2050	protein possibly involved in aromatic compounds catabolism
C9E88_RS04150	COG1566	PFAM secretion protein HlyD family protein
C9E88_RS04155	COG2814	Major facilitator Superfamily
C9E88_RS04160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C9E88_RS04210	COG2814	Major facilitator Superfamily
C9E88_RS04215	COG1024	Enoyl-CoA hydratase
C9E88_RS04215	COG1250	3-hydroxyacyl-CoA dehydrogenase
C9E88_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_RS04225	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS04275	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C9E88_RS04305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_RS04315	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_RS04320	COG1077	Cell shape determining protein MreB Mrl
C9E88_RS04325	COG1792	Involved in formation and maintenance of cell shape
C9E88_RS04330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C9E88_RS04335	COG0424	maF-like protein
C9E88_RS04340	COG1530	ribonuclease E activity
C9E88_RS04345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C9E88_RS04355	COG0560	Phosphoserine phosphatase
C9E88_RS04380	COG1113	amino acid transport
C9E88_RS04385	COG2828	Protein conserved in bacteria
C9E88_RS04390	COG0142	geranyltranstransferase activity
C9E88_RS04395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C9E88_RS04410	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9E88_RS04425	COG2194	sulfuric ester hydrolase activity
C9E88_RS04430	COG0745	RESPONSE REGULATOR receiver
C9E88_RS04435	COG0642	Histidine kinase
C9E88_RS04450	COG0004	ammonium transporteR
C9E88_RS04455	COG1126	abc transporter atp-binding protein
C9E88_RS04460	COG0765	amino acid transport
C9E88_RS04465	COG0765	amino acid transport
C9E88_RS04470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9E88_RS04475	COG3706	GGDEF domain
C9E88_RS04500	COG0525	valine-tRNA ligase activity
C9E88_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS04520	COG0393	Putative heavy-metal-binding
C9E88_RS04525	COG0393	Putative heavy-metal-binding
C9E88_RS04530	COG1538	Outer membrane efflux protein
C9E88_RS04535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9E88_RS04540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS04545	COG0671	phosphoesterase, PA-phosphatase related
C9E88_RS04560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C9E88_RS04565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C9E88_RS04570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C9E88_RS04580	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C9E88_RS04585	COG1648	precorrin-2 dehydrogenase activity
C9E88_RS04585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C9E88_RS04590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C9E88_RS04600	COG0531	amino acid
C9E88_RS04615	COG0321	lipoyl(octanoyl) transferase activity
C9E88_RS04620	COG2921	Belongs to the UPF0250 family
C9E88_RS04645	COG0586	Pfam SNARE associated Golgi protein
C9E88_RS04675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C9E88_RS04700	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C9E88_RS04705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9E88_RS04735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C9E88_RS04750	COG0358	DNA primase activity
C9E88_RS04760	COG0564	pseudouridine synthase activity
C9E88_RS04790	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9E88_RS04815	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C9E88_RS04825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C9E88_RS04830	COG0505	Belongs to the CarA family
C9E88_RS04855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9E88_RS04860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C9E88_RS04890	COG2851	Citrate transporter
C9E88_RS04895	COG1253	flavin adenine dinucleotide binding
C9E88_RS04925	COG2239	Acts as a magnesium transporter
C9E88_RS04935	COG0501	Belongs to the peptidase M48B family
C9E88_RS04940	COG1196	nuclear chromosome segregation
C9E88_RS04940	COG0741	lytic transglycosylase activity
C9E88_RS04940	COG0739	heme binding
C9E88_RS04950	COG0037	tRNA processing
C9E88_RS04960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C9E88_RS04965	COG0583	DNA-binding transcription factor activity
C9E88_RS04995	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C9E88_RS05010	COG0280	phosphate acetyltransferase
C9E88_RS05010	COG0281	malic enzyme
C9E88_RS05015	COG5001	Diguanylate cyclase
C9E88_RS05015	COG1716	ATPase activity
C9E88_RS05020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9E88_RS05025	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C9E88_RS05030	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C9E88_RS05045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C9E88_RS05065	COG1115	amino acid carrier protein
C9E88_RS05090	COG0019	diaminopimelate decarboxylase activity
C9E88_RS05105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C9E88_RS05110	COG0154	amidase activity
C9E88_RS05120	COG1522	sequence-specific DNA binding
C9E88_RS05125	COG1280	lysine exporter protein (LysE YggA)
C9E88_RS05155	COG1301	dicarboxylic acid transport
C9E88_RS05170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS05190	COG1671	Belongs to the UPF0178 family
C9E88_RS05205	COG4591	ABC-type transport system involved in lipoprotein release permease component
C9E88_RS05210	COG1136	(ABC) transporter
C9E88_RS05215	COG0658	competence protein
C9E88_RS05215	COG2333	competence protein COMEC
C9E88_RS05235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C9E88_RS05240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C9E88_RS05245	COG0628	permease
C9E88_RS05250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9E88_RS05280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C9E88_RS05295	COG2885	chlorophyll binding
C9E88_RS05300	COG0823	Involved in the tonB-independent uptake of proteins
C9E88_RS05320	COG0824	Thioesterase
C9E88_RS05330	COG2255	four-way junction helicase activity
C9E88_RS05360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C9E88_RS05360	COG0047	phosphoribosylformylglycinamidine synthase activity
C9E88_RS05385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C9E88_RS05385	COG3323	Protein of unknown function (DUF1653)
C9E88_RS05390	COG0778	Nitroreductase
C9E88_RS05400	COG1051	belongs to the nudix hydrolase family
C9E88_RS05400	COG1056	cytidyltransferase-related domain
C9E88_RS05405	COG2353	YceI-like domain
C9E88_RS05410	COG0583	DNA-binding transcription factor activity
C9E88_RS05420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C9E88_RS05430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C9E88_RS05435	COG0602	queuosine metabolic process
C9E88_RS05455	COG0583	DNA-binding transcription factor activity
C9E88_RS05460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C9E88_RS05465	COG4208	sulfate ABC transporter
C9E88_RS05480	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_RS05485	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C9E88_RS05490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C9E88_RS05495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C9E88_RS05525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9E88_RS05540	COG0681	Belongs to the peptidase S26 family
C9E88_RS05550	COG0571	ribonuclease III activity
C9E88_RS05555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C9E88_RS05565	COG1381	Involved in DNA repair and RecF pathway recombination
C9E88_RS05570	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C9E88_RS05600	COG0436	Aminotransferase
C9E88_RS05610	COG0052	Belongs to the universal ribosomal protein uS2 family
C9E88_RS05650	COG2951	lytic endotransglycosylase activity
C9E88_RS05670	COG0842	Transport permease protein
C9E88_RS05675	COG1131	(ABC) transporter
C9E88_RS05685	COG0582	viral genome integration into host DNA
C9E88_RS05745	COG3177	Filamentation induced by cAMP protein fic
C9E88_RS05780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C9E88_RS05820	COG3177	Filamentation induced by cAMP protein fic
C9E88_RS05825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS05835	COG1136	(ABC) transporter
C9E88_RS05840	COG0640	Transcriptional regulator
C9E88_RS05865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C9E88_RS05895	COG0640	Transcriptional regulator
C9E88_RS05905	COG0798	PFAM Bile acid sodium symporter
C9E88_RS05910	COG0431	NADPH-dependent FMN reductase
C9E88_RS05920	COG3177	Filamentation induced by cAMP protein fic
C9E88_RS05925	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C9E88_RS05960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C9E88_RS05985	COG3634	alkyl hydroperoxide reductase activity
C9E88_RS05990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9E88_RS05995	COG0826	peptidase U32
C9E88_RS06000	COG0640	Transcriptional regulator
C9E88_RS06005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9E88_RS06010	COG0798	PFAM Bile acid sodium symporter
C9E88_RS06015	COG0431	NADPH-dependent FMN reductase
C9E88_RS06020	COG0789	Transcriptional regulator
C9E88_RS06070	COG1720	tRNA m6t6A37 methyltransferase activity
C9E88_RS06080	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C9E88_RS06105	COG0494	nUDIX hydrolase
C9E88_RS06115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C9E88_RS06120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C9E88_RS06125	COG3139	Protein of unknown function (DUF1315)
C9E88_RS06130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9E88_RS06135	COG1301	dicarboxylic acid transport
C9E88_RS06145	COG0693	protein deglycase activity
C9E88_RS06155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C9E88_RS06160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C9E88_RS06185	COG2252	PERMEase
C9E88_RS06220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C9E88_RS06230	COG0527	aspartate kinase activity
C9E88_RS06235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C9E88_RS06240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C9E88_RS06255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C9E88_RS06270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C9E88_RS06295	COG1252	NADH dehydrogenase
C9E88_RS06300	COG1686	Belongs to the peptidase S11 family
C9E88_RS06315	COG1187	pseudouridine synthase activity
C9E88_RS06320	COG0436	Aminotransferase
C9E88_RS06330	COG0386	Belongs to the glutathione peroxidase family
C9E88_RS06365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C9E88_RS06395	COG0012	GTP binding
C9E88_RS06400	COG2011	ABC-type metal ion transport system permease component
C9E88_RS06450	COG0204	Acyl-transferase
C9E88_RS06500	COG0415	Belongs to the DNA photolyase family
C9E88_RS06530	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C9E88_RS06530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C9E88_RS06535	COG1254	Belongs to the acylphosphatase family
C9E88_RS06565	COG3634	alkyl hydroperoxide reductase activity
C9E88_RS06590	COG1643	Atp-dependent helicase
C9E88_RS06610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_RS06625	COG2707	UPF0756 membrane protein
C9E88_RS06645	COG0564	pseudouridine synthase activity
C9E88_RS06650	COG0802	atpase or kinase
C9E88_RS06655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C9E88_RS06660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C9E88_RS06665	COG1923	regulation of RNA biosynthetic process
C9E88_RS06670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_RS06685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C9E88_RS06695	COG1192	Involved in chromosome partitioning
C9E88_RS06700	COG1475	DNA binding
C9E88_RS06705	COG0811	peptide transport
C9E88_RS06715	COG1132	(ABC) transporter
C9E88_RS06720	COG1663	tetraacyldisaccharide 4'-kinase activity
C9E88_RS06740	COG0084	hydrolase, TatD family'
C9E88_RS06755	COG2165	general secretion pathway protein
C9E88_RS06775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C9E88_RS06805	COG0776	regulation of translation
C9E88_RS06825	COG2431	L-lysine efflux transmembrane transporter activity
C9E88_RS06840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C9E88_RS06845	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C9E88_RS06870	COG1253	flavin adenine dinucleotide binding
C9E88_RS06900	COG0308	aminopeptidase N
C9E88_RS06915	COG0589	response to stress
C9E88_RS06920	COG0589	response to stress
C9E88_RS06935	COG1309	transcriptional regulator
C9E88_RS06945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C9E88_RS06950	COG0583	DNA-binding transcription factor activity
C9E88_RS06960	COG0183	Belongs to the thiolase family
C9E88_RS06990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C9E88_RS06995	COG0824	Thioesterase
C9E88_RS07005	COG1454	alcohol dehydrogenase
C9E88_RS07010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C9E88_RS07030	COG0069	glutamate synthase activity
C9E88_RS07040	COG2308	Evidence 4 Homologs of previously reported genes of
C9E88_RS07050	COG1305	Transglutaminase-like
C9E88_RS07065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C9E88_RS07070	COG0305	Participates in initiation and elongation during chromosome replication
C9E88_RS07085	COG0360	Binds together with S18 to 16S ribosomal RNA
C9E88_RS07105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C9E88_RS07110	COG1845	cytochrome c oxidase, subunit III
C9E88_RS07115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C9E88_RS07120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C9E88_RS07145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_RS07165	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C9E88_RS07170	COG2890	protein-(glutamine-N5) methyltransferase activity
C9E88_RS07175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_RS07180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_RS07200	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS07205	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C9E88_RS07210	COG2814	Major facilitator Superfamily
C9E88_RS07215	COG1309	transcriptional regulator
C9E88_RS07220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C9E88_RS07230	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C9E88_RS07250	COG0477	Major facilitator Superfamily
C9E88_RS07255	COG0729	surface antigen
C9E88_RS07280	COG1570	exodeoxyribonuclease VII activity
C9E88_RS07305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C9E88_RS07355	COG0582	viral genome integration into host DNA
C9E88_RS07400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9E88_RS07405	COG4197	protein conserved in bacteria, prophage-related
C9E88_RS07430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C9E88_RS07515	COG1278	Cold shock
C9E88_RS07535	COG5410	chromosome segregation
C9E88_RS07570	COG4387	Mu-like prophage protein GP36
C9E88_RS07685	COG3038	cytochrome b561
C9E88_RS07735	COG2814	Major facilitator Superfamily
C9E88_RS07745	COG1525	nuclease
C9E88_RS07750	COG0583	DNA-binding transcription factor activity
C9E88_RS07755	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS07800	COG0697	spore germination
C9E88_RS07820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C9E88_RS07825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C9E88_RS07840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C9E88_RS07865	COG1132	(ABC) transporter
C9E88_RS07875	COG3122	Protein conserved in bacteria
C9E88_RS07895	COG0640	Transcriptional regulator
C9E88_RS07900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C9E88_RS07910	COG0789	Transcriptional regulator
C9E88_RS07925	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS07930	COG0183	Belongs to the thiolase family
C9E88_RS07935	COG0427	acetyl-CoA hydrolase
C9E88_RS07960	COG4521	taurine ABC transporter
C9E88_RS07965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C9E88_RS07970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_RS07975	COG2175	clavaminate synthase activity
C9E88_RS07990	COG4770	biotin carboxylase activity
C9E88_RS08025	COG1733	regulation of RNA biosynthetic process
C9E88_RS08035	COG0778	Nitroreductase
C9E88_RS08045	COG0864	Transcriptional regulator
C9E88_RS08055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9E88_RS08070	COG1959	2 iron, 2 sulfur cluster binding
C9E88_RS08085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C9E88_RS08090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_RS08095	COG0730	response to heat
C9E88_RS08125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C9E88_RS08140	COG2814	Major facilitator Superfamily
C9E88_RS08180	COG3845	ABC transporter
C9E88_RS08185	COG4603	Belongs to the binding-protein-dependent transport system permease family
C9E88_RS08190	COG1079	Belongs to the binding-protein-dependent transport system permease family
C9E88_RS08200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9E88_RS08205	COG0183	Belongs to the thiolase family
C9E88_RS08210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C9E88_RS08215	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C9E88_RS08220	COG3135	benzoate transporter
C9E88_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS08230	COG0543	2 iron, 2 sulfur cluster binding
C9E88_RS08230	COG0633	Ferredoxin
C9E88_RS08235	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
C9E88_RS08240	COG4638	Rieske (2fe-2S)
C9E88_RS08250	COG4829	muconolactone delta-isomerase
C9E88_RS08255	COG4948	Mandelate Racemase Muconate Lactonizing
C9E88_RS08260	COG0583	DNA-binding transcription factor activity
C9E88_RS08265	COG2814	Major facilitator Superfamily
C9E88_RS08275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C9E88_RS08280	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_RS08320	COG0281	malic enzyme
C9E88_RS08325	COG0697	spore germination
C9E88_RS08330	COG1346	cytolysis
C9E88_RS08335	COG1380	Effector of murein hydrolase LrgA
C9E88_RS08340	COG0583	DNA-binding transcription factor activity
C9E88_RS08355	COG2351	hydroxyisourate hydrolase activity
C9E88_RS08360	COG2233	PERMEase
C9E88_RS08370	COG4266	Belongs to the allantoicase family
C9E88_RS08375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_RS08380	COG0583	DNA-binding transcription factor activity
C9E88_RS08385	COG1116	anion transmembrane transporter activity
C9E88_RS08385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_RS08395	COG2223	nitrite transmembrane transporter activity
C9E88_RS08400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_RS08405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_RS08410	COG0243	molybdopterin cofactor binding
C9E88_RS08420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C9E88_RS08435	COG0315	cyclic pyranopterin monophosphate synthase activity
C9E88_RS08435	COG0521	Mo-molybdopterin cofactor biosynthetic process
C9E88_RS08440	COG0303	'Molybdopterin
C9E88_RS08445	COG0725	ABC transporter, periplasmic molybdate-binding protein
C9E88_RS08450	COG4149	molybdate abc transporter
C9E88_RS08455	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C9E88_RS08460	COG1648	precorrin-2 dehydrogenase activity
C9E88_RS08460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C9E88_RS08475	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS08520	COG3971	2-oxopent-4-enoate hydratase activity
C9E88_RS08535	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS08570	COG4628	conserved protein (DUF2132)
C9E88_RS08595	COG3550	peptidyl-serine autophosphorylation
C9E88_RS08610	COG2801	Transposase and inactivated derivatives
C9E88_RS08620	COG2885	chlorophyll binding
C9E88_RS08705	COG0596	Alpha beta hydrolase
C9E88_RS08755	COG0439	Biotin carboxylase
C9E88_RS08765	COG2199	diguanylate cyclase activity
C9E88_RS08770	COG2814	Major facilitator Superfamily
C9E88_RS08785	COG3706	GGDEF domain
C9E88_RS08815	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
C9E88_RS08830	COG0552	protein localization to endoplasmic reticulum
C9E88_RS08835	COG0612	Peptidase, M16
C9E88_RS08865	COG0517	IMP dehydrogenase activity
C9E88_RS08875	COG0133	tryptophan synthase activity
C9E88_RS08885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9E88_RS08910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C9E88_RS08940	COG0537	adenosine 5'-monophosphoramidase activity
C9E88_RS08960	COG1294	oxidase, subunit
C9E88_RS08965	COG4890	Cyd operon protein YbgT
C9E88_RS08985	COG0772	Belongs to the SEDS family
C9E88_RS09000	COG0148	phosphopyruvate hydratase activity
C9E88_RS09020	COG0583	DNA-binding transcription factor activity
C9E88_RS09030	COG2814	Major facilitator Superfamily
C9E88_RS09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_RS09045	COG1902	pentaerythritol trinitrate reductase activity
C9E88_RS09055	COG2267	carboxylic ester hydrolase activity
C9E88_RS09060	COG0583	DNA-binding transcription factor activity
C9E88_RS09065	COG0024	Methionine aminopeptidase
C9E88_RS09070	COG1114	Component of the transport system for branched-chain amino acids
C9E88_RS09120	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C9E88_RS09160	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C9E88_RS09175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C9E88_RS09190	COG2814	Major facilitator Superfamily
C9E88_RS09225	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9E88_RS09230	COG2207	Transcriptional regulator
C9E88_RS09240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_RS09250	COG0730	response to heat
C9E88_RS09320	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS09325	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS09345	COG1058	Belongs to the CinA family
C9E88_RS09345	COG1546	Belongs to the CinA family
C9E88_RS09350	COG0372	Belongs to the citrate synthase family
C9E88_RS09380	COG0542	response to heat
C9E88_RS09385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C9E88_RS09395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C9E88_RS09405	COG0463	Glycosyl transferase, family 2
C9E88_RS09425	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C9E88_RS09430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C9E88_RS09445	COG0569	domain protein
C9E88_RS09450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C9E88_RS09475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C9E88_RS09485	COG1585	Membrane protein implicated in regulation of membrane protease activity
C9E88_RS09515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C9E88_RS09545	COG0822	iron-sulfur transferase activity
C9E88_RS09550	COG0316	Belongs to the HesB IscA family
C9E88_RS09580	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C9E88_RS09590	COG1027	Aspartate ammonia-lyase
C9E88_RS09630	COG0210	DNA helicase
C9E88_RS09635	COG3781	membrane
C9E88_RS09640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C9E88_RS09650	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_RS09695	COG0697	spore germination
C9E88_RS09710	COG0126	phosphoglycerate kinase activity
C9E88_RS09720	COG0424	maF-like protein
C9E88_RS09735	COG2850	peptidyl-arginine hydroxylation
C9E88_RS09745	COG2197	response regulator
C9E88_RS09755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C9E88_RS09760	COG0702	epimerase
C9E88_RS09780	COG1218	3'(2'),5'-bisphosphate nucleotidase
C9E88_RS09785	COG1011	Hydrolase
C9E88_RS09790	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C9E88_RS09800	COG2137	regulation of response to DNA damage stimulus
C9E88_RS09815	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C9E88_RS09835	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_RS09850	COG0575	Belongs to the CDS family
C9E88_RS09855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C9E88_RS09875	COG3852	Histidine kinase
C9E88_RS09890	COG2814	Major facilitator Superfamily
C9E88_RS09930	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
C9E88_RS09935	COG0138	bifunctional purine biosynthesis protein purh
C9E88_RS09965	COG1464	Belongs to the NlpA lipoprotein family
C9E88_RS09970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C9E88_RS09975	COG2011	ABC-type metal ion transport system permease component
C9E88_RS10015	COG3706	GGDEF domain
C9E88_RS10025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C9E88_RS10035	COG4122	O-methyltransferase activity
C9E88_RS10040	COG0589	response to stress
C9E88_RS10045	COG0110	maltose O-acetyltransferase activity
C9E88_RS10060	COG2274	protein secretion by the type I secretion system
C9E88_RS10070	COG1137	ATPase activity
C9E88_RS10075	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C9E88_RS10085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C9E88_RS10115	COG0519	Catalyzes the synthesis of GMP from XMP
C9E88_RS10115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C9E88_RS10120	COG1280	lysine exporter protein (LysE YggA)
C9E88_RS10145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C9E88_RS10150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C9E88_RS10170	COG2391	methyltransferase activity
C9E88_RS10190	COG2070	2-Nitropropane dioxygenase
C9E88_RS10210	COG1215	transferase activity, transferring glycosyl groups
C9E88_RS10215	COG1649	PFAM Uncharacterised BCR, COG1649
C9E88_RS10215	COG0726	polysaccharide deacetylase
C9E88_RS10240	COG1309	transcriptional regulator
C9E88_RS10245	COG4566	intracellular signal transduction
C9E88_RS10305	COG0352	thiamine-phosphate diphosphorylase activity
C9E88_RS10335	COG0612	Peptidase, M16
C9E88_RS10345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_RS10350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C9E88_RS10350	COG2755	lipolytic protein G-D-S-L family
C9E88_RS10415	COG2815	serine threonine protein kinase
C9E88_RS10415	COG0515	serine threonine protein kinase
C9E88_RS10435	COG0387	Pfam Sodium calcium exchanger
C9E88_RS10440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C9E88_RS10450	COG1610	YqeY-like protein
C9E88_RS10495	COG0167	dihydroorotate dehydrogenase activity
C9E88_RS10520	COG0778	Nitroreductase
C9E88_RS10530	COG0513	Belongs to the DEAD box helicase family
C9E88_RS10555	COG2363	Small membrane protein
C9E88_RS10575	COG0625	glutathione transferase activity
C9E88_RS10580	COG0659	secondary active sulfate transmembrane transporter activity
C9E88_RS10595	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C9E88_RS10635	COG0540	Belongs to the ATCase OTCase family
C9E88_RS10690	COG0667	Aldo Keto reductase
C9E88_RS10700	COG1765	OsmC-like protein
C9E88_RS10820	COG0714	Associated with various cellular activities
C9E88_RS10825	COG2879	small protein
C9E88_RS10830	COG1966	Carbon starvation protein
C9E88_RS10835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C9E88_RS10840	COG1509	lysine 2,3-aminomutase activity
C9E88_RS10880	COG1067	ATP-dependent peptidase activity
C9E88_RS10885	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C9E88_RS10890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C9E88_RS10895	COG0583	DNA-binding transcription factor activity
C9E88_RS10920	COG1686	Belongs to the peptidase S11 family
C9E88_RS10925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C9E88_RS10935	COG0697	spore germination
C9E88_RS10940	COG1396	sequence-specific DNA binding
C9E88_RS10950	COG0482	sulfurtransferase activity
C9E88_RS10955	COG2915	High frequency lysogenization protein hflD homolog
C9E88_RS10990	COG0616	signal peptide processing
C9E88_RS11010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C9E88_RS11020	COG0573	inorganic phosphate transmembrane transporter activity
C9E88_RS11025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C9E88_RS11035	COG0076	glutamate decarboxylase activity
C9E88_RS11040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C9E88_RS11050	COG0671	phosphoesterase, PA-phosphatase related
C9E88_RS11055	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C9E88_RS11065	COG2814	Major facilitator Superfamily
C9E88_RS11070	COG1733	regulation of RNA biosynthetic process
C9E88_RS11075	COG0702	epimerase
C9E88_RS11115	COG0556	nucleotide-excision repair
C9E88_RS11125	COG2199	diguanylate cyclase activity
C9E88_RS11145	COG2175	clavaminate synthase activity
C9E88_RS11160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C9E88_RS11180	COG2233	PERMEase
C9E88_RS11185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C9E88_RS11190	COG0251	oxidation-reduction process
C9E88_RS11195	COG1335	isochorismatase
C9E88_RS11200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_RS11205	COG0596	Alpha beta hydrolase
C9E88_RS11215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C9E88_RS11220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C9E88_RS11225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C9E88_RS11275	COG0583	DNA-binding transcription factor activity
C9E88_RS11285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C9E88_RS11290	COG3161	chorismate lyase activity
C9E88_RS11305	COG0174	glutamine synthetase
C9E88_RS11320	COG0438	transferase activity, transferring glycosyl groups
C9E88_RS11360	COG0662	Cupin 2, conserved barrel domain protein
C9E88_RS11360	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C9E88_RS11370	COG0512	Glutamine amidotransferase of anthranilate synthase
C9E88_RS11375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C9E88_RS11395	COG0302	gtp cyclohydrolase
C9E88_RS11420	COG3739	integral membrane protein
C9E88_RS11435	COG1741	Belongs to the pirin family
C9E88_RS11500	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C9E88_RS11510	COG2184	nucleotidyltransferase activity
C9E88_RS11560	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_RS11560	COG1902	pentaerythritol trinitrate reductase activity
C9E88_RS11575	COG3706	GGDEF domain
C9E88_RS11580	COG0418	dihydroorotase activity
C9E88_RS11585	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C9E88_RS11610	COG0833	amino acid
C9E88_RS11620	COG0833	amino acid
C9E88_RS11655	COG4172	Belongs to the ABC transporter superfamily
C9E88_RS11660	COG4239	(ABC) transporter, permease
C9E88_RS11665	COG4174	ABC transporter (Permease)
C9E88_RS11675	COG1388	LysM domain
C9E88_RS11675	COG0741	lytic transglycosylase activity
C9E88_RS11700	COG0657	acetylesterase activity
C9E88_RS11730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_RS11735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C9E88_RS11740	COG0596	Alpha beta hydrolase
C9E88_RS11750	COG1309	transcriptional regulator
C9E88_RS11755	COG0789	Transcriptional regulator
C9E88_RS11765	COG0006	proline dipeptidase activity
C9E88_RS11795	COG1944	ATP diphosphatase activity
C9E88_RS11810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C9E88_RS11820	COG2234	aminopeptidase activity
C9E88_RS11830	COG3384	dioxygenase
C9E88_RS11840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C9E88_RS11845	COG2878	Part of a membrane complex involved in electron transport
C9E88_RS11850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C9E88_RS11875	COG0768	penicillin binding
C9E88_RS11880	COG0742	ribosomal rna small subunit methyltransferase
C9E88_RS11905	COG3015	lipoprotein NlpE involved in copper resistance
C9E88_RS11910	COG4774	siderophore transport
C9E88_RS11950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C9E88_RS11960	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C9E88_RS11975	COG0477	Major facilitator Superfamily
C9E88_RS11990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C9E88_RS12030	COG1695	Transcriptional regulator
C9E88_RS12055	COG0175	sulfate reduction
C9E88_RS12070	COG2268	Band 7 protein
C9E88_RS12075	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C9E88_RS12085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C9E88_RS12100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C9E88_RS12105	COG1053	succinate dehydrogenase
C9E88_RS12110	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C9E88_RS12125	COG2072	flavoprotein involved in K transport
C9E88_RS12130	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS12145	COG0714	Associated with various cellular activities
C9E88_RS12155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C9E88_RS12155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9E88_RS12215	COG2321	neutral zinc metallopeptidase
C9E88_RS12220	COG2354	Protein conserved in bacteria
C9E88_RS12245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C9E88_RS12250	COG1773	rubredoxin
C9E88_RS12255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C9E88_RS12260	COG2267	carboxylic ester hydrolase activity
C9E88_RS12265	COG0583	DNA-binding transcription factor activity
C9E88_RS12270	COG2197	response regulator
C9E88_RS12290	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C9E88_RS12295	COG4181	ATPase activity
C9E88_RS12320	COG4771	TonB-dependent receptor
C9E88_RS12350	COG0306	phosphate transporter
C9E88_RS12370	COG2852	Protein conserved in bacteria
C9E88_RS12375	COG3706	GGDEF domain
C9E88_RS12380	COG2376	Dihydroxyacetone kinase
C9E88_RS12385	COG0210	DNA helicase
C9E88_RS12395	COG2223	nitrite transmembrane transporter activity
C9E88_RS12405	COG0242	peptide deformylase activity
C9E88_RS12425	COG0477	Major facilitator Superfamily
C9E88_RS12460	COG2199	diguanylate cyclase activity
C9E88_RS12460	COG2203	Gaf domain
C9E88_RS12475	COG4681	YaeQ
C9E88_RS12480	COG0523	cobalamin synthesis protein
C9E88_RS12495	COG0583	DNA-binding transcription factor activity
C9E88_RS12500	COG2814	Major facilitator Superfamily
C9E88_RS12510	COG1607	acyl-coa hydrolase
C9E88_RS12520	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9E88_RS12525	COG1115	amino acid carrier protein
C9E88_RS12530	COG0786	glutamate:sodium symporter activity
C9E88_RS12545	COG2814	Major facilitator Superfamily
C9E88_RS12550	COG1289	transmembrane transporter activity
C9E88_RS12560	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C9E88_RS12620	COG2832	Protein of unknown function (DUF454)
C9E88_RS12650	COG0840	transmembrane signaling receptor activity
C9E88_RS12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS12685	COG0442	prolyl-tRNA aminoacylation
C9E88_RS12720	COG0489	protein tyrosine kinase activity
C9E88_RS12740	COG0583	DNA-binding transcription factor activity
C9E88_RS12745	COG2885	chlorophyll binding
C9E88_RS12750	COG0204	Acyl-transferase
C9E88_RS12765	COG2894	cell division
C9E88_RS12770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C9E88_RS12805	COG1674	ftsk spoiiie
C9E88_RS12805	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C9E88_RS12810	COG0492	ferredoxin-NADP+ reductase activity
C9E88_RS12815	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C9E88_RS12825	COG0456	acetyltransferase
C9E88_RS12850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C9E88_RS12865	COG1981	membrane
C9E88_RS12870	COG1652	LysM domain
C9E88_RS12880	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS12890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C9E88_RS12895	COG1399	metal-binding, possibly nucleic acid-binding protein
C9E88_RS12900	COG3101	peptidyl-lysine hydroxylation
C9E88_RS12905	COG0009	L-threonylcarbamoyladenylate synthase
C9E88_RS12915	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C9E88_RS12920	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C9E88_RS12925	COG1187	pseudouridine synthase activity
C9E88_RS12940	COG4106	trans-aconitate 2-methyltransferase activity
C9E88_RS12955	COG2267	carboxylic ester hydrolase activity
C9E88_RS12965	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C9E88_RS12970	COG2193	ferroxidase activity
C9E88_RS12975	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C9E88_RS12985	COG2801	Transposase and inactivated derivatives
C9E88_RS12990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C9E88_RS12995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C9E88_RS13015	COG0730	response to heat
C9E88_RS13035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C9E88_RS13070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C9E88_RS13105	COG2132	Multicopper oxidase
C9E88_RS13115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C9E88_RS13125	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C9E88_RS13140	COG1968	undecaprenyl-diphosphatase activity
C9E88_RS13145	COG1214	PFAM Peptidase M22, glycoprotease
C9E88_RS13155	COG0494	nUDIX hydrolase
C9E88_RS13195	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C9E88_RS13205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C9E88_RS13210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C9E88_RS13275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C9E88_RS13285	COG1764	response to oxidative stress
C9E88_RS13330	COG0037	tRNA processing
C9E88_RS13340	COG0248	Ppx GppA phosphatase
C9E88_RS13365	COG0072	phenylalanine-tRNA ligase activity
C9E88_RS13370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C9E88_RS13425	COG1238	metal cluster binding
C9E88_RS13435	COG0625	glutathione transferase activity
C9E88_RS13475	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_RS13490	COG1660	Displays ATPase and GTPase activities
C9E88_RS13505	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C9E88_RS13510	COG0617	tRNA 3'-terminal CCA addition
C9E88_RS13515	COG1596	polysaccharide export
C9E88_RS13515	COG1555	photosystem II stabilization
C9E88_RS13520	COG3956	TIGRFAM MazG family protein
C9E88_RS13525	COG0300	oxidoreductase activity
C9E88_RS13540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C9E88_RS13560	COG1426	Protein conserved in bacteria
C9E88_RS13595	COG4585	Histidine kinase
C9E88_RS13625	COG0440	acetolactate synthase activity
C9E88_RS13630	COG0028	Belongs to the TPP enzyme family
C9E88_RS13655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS13660	COG0577	efflux transmembrane transporter activity
C9E88_RS13660	COG1136	(ABC) transporter
C9E88_RS13700	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C9E88_RS13710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C9E88_RS13715	COG1162	GTPase activity
C9E88_RS13725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C9E88_RS13740	COG0084	hydrolase, TatD family'
C9E88_RS13755	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C9E88_RS13780	COG0793	Belongs to the peptidase S41A family
C9E88_RS13805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C9E88_RS13810	COG0280	phosphate acetyltransferase
C9E88_RS13810	COG0857	belongs to the CobB CobQ family
C9E88_RS13835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C9E88_RS13835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C9E88_RS13855	COG0740	serine-type endopeptidase activity
C9E88_RS13865	COG4774	siderophore transport
C9E88_RS13870	COG4774	siderophore transport
C9E88_RS13875	COG4774	siderophore transport
C9E88_RS13880	COG3128	pkhd-type hydroxylase
C9E88_RS13890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C9E88_RS13900	COG2813	Specifically methylates the guanine in position
C9E88_RS13900	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C9E88_RS13930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C9E88_RS14015	COG0788	formyltetrahydrofolate deformylase activity
C9E88_RS14040	COG4651	solute:proton antiporter activity
C9E88_RS14040	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C9E88_RS14065	COG0724	RNA recognition motif
C9E88_RS14070	COG0210	DNA helicase
C9E88_RS14085	COG1929	Belongs to the glycerate kinase type-1 family
C9E88_RS14125	COG2900	Belongs to the SlyX family
C9E88_RS14130	COG0488	(ABC) transporter
C9E88_RS14145	COG1560	Kdo2-lipid A biosynthetic process
C9E88_RS14210	COG0473	3-isopropylmalate dehydrogenase activity
C9E88_RS14225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C9E88_RS14235	COG0583	DNA-binding transcription factor activity
C9E88_RS14290	COG1522	sequence-specific DNA binding
C9E88_RS14295	COG1960	acyl-CoA dehydrogenase activity
C9E88_RS14310	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C9E88_RS14335	COG0446	pyridine nucleotide-disulphide oxidoreductase
C9E88_RS14340	COG3384	dioxygenase
C9E88_RS14345	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS14360	COG4638	Rieske (2fe-2S)
C9E88_RS14365	COG0583	DNA-binding transcription factor activity
C9E88_RS14385	COG4569	acetaldehyde dehydrogenase (acetylating) activity
C9E88_RS14390	COG3971	2-oxopent-4-enoate hydratase activity
C9E88_RS14400	COG0564	pseudouridine synthase activity
C9E88_RS14405	COG1530	ribonuclease E activity
C9E88_RS14410	COG0318	PFAM AMP-dependent synthetase and ligase
C9E88_RS14440	COG1983	PspC domain protein
C9E88_RS14445	COG3620	sequence-specific DNA binding
C9E88_RS14445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C9E88_RS14445	COG0617	tRNA 3'-terminal CCA addition
C9E88_RS14505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C9E88_RS14530	COG0493	'glutamate synthase
C9E88_RS14540	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C9E88_RS14545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C9E88_RS14560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C9E88_RS14570	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C9E88_RS14570	COG0644	oxidoreductase
C9E88_RS14595	COG0425	Belongs to the sulfur carrier protein TusA family
C9E88_RS14600	COG4535	Mg2 and Co2 transporter CorC
C9E88_RS14605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C9E88_RS14610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_RS14610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C9E88_RS14635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C9E88_RS14645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C9E88_RS14670	COG0789	Transcriptional regulator
C9E88_RS14675	COG2841	Protein conserved in bacteria
C9E88_RS14685	COG0598	Magnesium transport protein CorA
C9E88_RS14690	COG1185	polyribonucleotide nucleotidyltransferase activity
C9E88_RS14700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_RS14705	COG1074	ATP-dependent DNA helicase activity
C9E88_RS14710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C9E88_RS14740	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C9E88_RS14780	COG0427	acetyl-CoA hydrolase
C9E88_RS14790	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C9E88_RS14815	COG0326	Molecular chaperone. Has ATPase activity
C9E88_RS14825	COG3047	cAMP biosynthetic process
C9E88_RS14830	COG2056	Na+-H+ antiporter family
C9E88_RS14860	COG0085	RNA polymerase activity
C9E88_RS14870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C9E88_RS14875	COG0081	regulation of translation
C9E88_RS14930	COG0546	phosphoglycolate phosphatase activity
C9E88_RS14980	COG0181	hydroxymethylbilane synthase activity
C9E88_RS14990	COG3275	phosphorelay sensor kinase activity
C9E88_RS15005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C9E88_RS15105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C9E88_RS15125	COG0697	spore germination
C9E88_RS15135	COG0531	amino acid
C9E88_RS15155	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C9E88_RS15200	COG3158	transport of potassium into the cell
C9E88_RS15235	COG1335	isochorismatase
C9E88_RS15250	COG1309	transcriptional regulator
C9E88_RS15260	COG0629	single-stranded DNA binding
C9E88_RS15265	COG2814	Major facilitator Superfamily
C9E88_RS15275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C9E88_RS15330	COG3162	membrane
C9E88_RS15335	COG2205	protein histidine kinase activity
C9E88_RS15335	COG0784	Response regulator, receiver
C9E88_RS15350	COG0431	NADPH-dependent FMN reductase
C9E88_RS15365	COG0307	riboflavin synthase, alpha
C9E88_RS15375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C9E88_RS15385	COG0668	transmembrane transport
C9E88_RS15390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9E88_RS15395	COG1519	Transferase
C9E88_RS15400	COG1902	pentaerythritol trinitrate reductase activity
C9E88_RS15425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C9E88_RS15455	COG2119	membrane
C9E88_RS15485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C9E88_RS15495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C9E88_RS15500	COG1181	Belongs to the D-alanine--D-alanine ligase family
C9E88_RS15505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9E88_RS15515	COG0189	ligase activity
C9E88_RS15520	COG1278	Cold shock
C9E88_RS15530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C9E88_RS15535	COG0708	Exodeoxyribonuclease III
C9E88_RS15555	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C9E88_RS15595	COG1247	-acetyltransferase
C9E88_RS15635	COG3150	esterase
C9E88_RS15645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C9E88_RS15650	COG2918	glutathione biosynthetic process
C9E88_RS15665	COG2733	membrane
C9E88_RS15695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C9E88_RS15725	COG3830	Belongs to the UPF0237 family
C9E88_RS15725	COG0560	Phosphoserine phosphatase
C9E88_RS15735	COG0385	Bile acid
C9E88_RS15740	COG1335	isochorismatase
C9E88_RS15750	COG2814	Major facilitator Superfamily
C9E88_RS15755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C9E88_RS15770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C9E88_RS15775	COG5001	Diguanylate cyclase
C9E88_RS15775	COG3300	MHYT domain
C9E88_RS15785	COG2983	Belongs to the UPF0260 family
C9E88_RS15790	COG5487	UPF0391 membrane protein
C9E88_RS15795	COG0728	peptidoglycan biosynthetic process
C9E88_RS15800	COG3023	N-Acetylmuramoyl-L-alanine amidase
C9E88_RS15815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C9E88_RS15830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C9E88_RS15835	COG0546	phosphoglycolate phosphatase activity
C9E88_RS15840	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS15865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C9E88_RS15870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C9E88_RS15875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C9E88_RS15880	COG1116	anion transmembrane transporter activity
C9E88_RS15885	COG1309	transcriptional regulator
C9E88_RS15905	COG0196	riboflavin kinase activity
C9E88_RS15910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C9E88_RS15920	COG1047	Peptidyl-prolyl cis-trans
C9E88_RS15950	COG2814	Major facilitator Superfamily
C9E88_RS15955	COG2814	Major facilitator Superfamily
C9E88_RS15995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C9E88_RS16000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C9E88_RS16005	COG2951	lytic endotransglycosylase activity
C9E88_RS16010	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C9E88_RS16025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C9E88_RS16050	COG2814	Major facilitator Superfamily
C9E88_RS16055	COG0861	Integral membrane protein TerC family
C9E88_RS16060	COG0402	S-adenosylhomocysteine deaminase activity
C9E88_RS16095	COG0706	membrane insertase activity
C9E88_RS16100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C9E88_RS16125	COG1196	nuclear chromosome segregation
C9E88_RS16125	COG0741	lytic transglycosylase activity
C9E88_RS16125	COG0739	heme binding
C9E88_RS16140	COG0739	heme binding
C9E88_RS16140	COG1196	nuclear chromosome segregation
C9E88_RS16140	COG0741	lytic transglycosylase activity
C9E88_RS16205	COG1192	Involved in chromosome partitioning
C9E88_RS16270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_RS16300	COG2826	transposase and inactivated derivatives, IS30 family
C9E88_RS16320	COG0673	inositol 2-dehydrogenase activity
C9E88_RS16325	COG1324	tolerance protein
C9E88_RS16350	COG2826	transposase and inactivated derivatives, IS30 family
C9E88_RS16370	COG1525	nuclease
C9E88_RS16385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C9E88_RS16395	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C9E88_RS16420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C9E88_RS16450	COG0564	pseudouridine synthase activity
C9E88_RS16460	COG0358	DNA primase activity
C9E88_RS16475	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C9E88_RS16505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C9E88_RS16510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C9E88_RS16535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C9E88_RS16565	COG0586	Pfam SNARE associated Golgi protein
C9E88_RS16590	COG2921	Belongs to the UPF0250 family
C9E88_RS16595	COG0321	lipoyl(octanoyl) transferase activity
C9E88_RS16610	COG0531	amino acid
C9E88_RS16620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C9E88_RS16625	COG1648	precorrin-2 dehydrogenase activity
C9E88_RS16625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C9E88_RS16630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C9E88_RS16640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C9E88_RS16645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C9E88_RS16650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C9E88_RS16665	COG0671	phosphoesterase, PA-phosphatase related
C9E88_RS16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C9E88_RS16675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C9E88_RS16680	COG1538	Outer membrane efflux protein
C9E88_RS16685	COG0393	Putative heavy-metal-binding
C9E88_RS16690	COG0393	Putative heavy-metal-binding
C9E88_RS16700	COG1028	Short-chain dehydrogenase reductase Sdr
C9E88_RS16710	COG0525	valine-tRNA ligase activity
C9E88_RS16735	COG3706	GGDEF domain
C9E88_RS16740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C9E88_RS16745	COG0765	amino acid transport
C9E88_RS16750	COG0765	amino acid transport
C9E88_RS16755	COG1126	abc transporter atp-binding protein
C9E88_RS16760	COG0004	ammonium transporteR
C9E88_RS16775	COG0642	Histidine kinase
C9E88_RS16780	COG0745	RESPONSE REGULATOR receiver
C9E88_RS16785	COG2194	sulfuric ester hydrolase activity
C9E88_RS16800	COG1752	Esterase of the alpha-beta hydrolase superfamily
C9E88_RS16815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C9E88_RS16820	COG0142	geranyltranstransferase activity
C9E88_RS16825	COG2828	Protein conserved in bacteria
C9E88_RS16830	COG1113	amino acid transport
C9E88_RS16855	COG0560	Phosphoserine phosphatase
C9E88_RS16865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C9E88_RS16870	COG1530	ribonuclease E activity
C9E88_RS16875	COG0424	maF-like protein
C9E88_RS16880	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C9E88_RS16885	COG1792	Involved in formation and maintenance of cell shape
C9E88_RS16890	COG1077	Cell shape determining protein MreB Mrl
C9E88_RS16895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_RS16905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C9E88_RS16935	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C9E88_RS16975	COG1115	amino acid carrier protein
C9E88_RS16995	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C9E88_RS17010	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C9E88_RS17015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C9E88_RS17020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C9E88_RS17025	COG1716	ATPase activity
C9E88_RS17025	COG5001	Diguanylate cyclase
C9E88_RS17030	COG0280	phosphate acetyltransferase
C9E88_RS17030	COG0281	malic enzyme
C9E88_RS17045	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
C9E88_RS17075	COG0583	DNA-binding transcription factor activity
C9E88_RS17080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C9E88_RS17090	COG0037	tRNA processing
C9E88_RS17100	COG0741	lytic transglycosylase activity
C9E88_RS17100	COG1196	nuclear chromosome segregation
C9E88_RS17100	COG0739	heme binding
C9E88_RS17105	COG0501	Belongs to the peptidase M48B family
C9E88_RS17115	COG2239	Acts as a magnesium transporter
C9E88_RS17155	COG1253	flavin adenine dinucleotide binding
C9E88_RS17160	COG2851	Citrate transporter
C9E88_RS17190	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C9E88_RS17195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C9E88_RS17220	COG0505	Belongs to the CarA family
C9E88_RS17245	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
C9E88_RS17265	COG3173	Aminoglycoside phosphotransferase
C9E88_RS17270	COG0488	(ABC) transporter
C9E88_RS17305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C9E88_RS17335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C9E88_RS17350	COG1192	Involved in chromosome partitioning
C9E88_RS17355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C9E88_RS17370	COG1106	Psort location Cytoplasmic, score
C9E88_RS17405	COG2801	Transposase and inactivated derivatives