locus-tag	class	description
AOY20_RS00005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOY20_RS00035	COG0583	DNA-binding transcription factor activity
AOY20_RS00045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOY20_RS00055	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOY20_RS00060	COG4181	ATPase activity
AOY20_RS00090	COG0500	methyltransferase
AOY20_RS00095	COG4771	TonB-dependent receptor
AOY20_RS00115	COG0306	phosphate transporter
AOY20_RS00150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AOY20_RS00155	COG0477	Major facilitator Superfamily
AOY20_RS00160	COG0477	Major facilitator Superfamily
AOY20_RS00175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AOY20_RS00205	COG2304	oxidoreductase activity
AOY20_RS00210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOY20_RS00215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOY20_RS00240	COG0505	Belongs to the CarA family
AOY20_RS00245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOY20_RS00280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AOY20_RS00290	COG2081	HI0933 family
AOY20_RS00295	COG0668	transmembrane transport
AOY20_RS00310	COG0583	DNA-binding transcription factor activity
AOY20_RS00330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOY20_RS00340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOY20_RS00345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOY20_RS00350	COG0713	ATP synthesis coupled electron transport
AOY20_RS00360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOY20_RS00375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOY20_RS00385	COG0649	NAD binding
AOY20_RS00385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOY20_RS00395	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOY20_RS00405	COG0142	geranyltranstransferase activity
AOY20_RS00410	COG2199	diguanylate cyclase activity
AOY20_RS00415	COG2828	Protein conserved in bacteria
AOY20_RS00420	COG1113	amino acid transport
AOY20_RS00440	COG0560	Phosphoserine phosphatase
AOY20_RS00450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOY20_RS00460	COG0424	maF-like protein
AOY20_RS00470	COG1792	Involved in formation and maintenance of cell shape
AOY20_RS00475	COG1077	Cell shape determining protein MreB Mrl
AOY20_RS00480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOY20_RS00490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOY20_RS00525	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AOY20_RS00535	COG2321	neutral zinc metallopeptidase
AOY20_RS00540	COG2354	Protein conserved in bacteria
AOY20_RS00550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AOY20_RS00560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOY20_RS00575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOY20_RS00580	COG1053	succinate dehydrogenase
AOY20_RS00585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOY20_RS00645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOY20_RS00645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOY20_RS00650	COG2193	ferroxidase activity
AOY20_RS00655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOY20_RS00675	COG0730	response to heat
AOY20_RS00680	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AOY20_RS00680	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AOY20_RS00695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOY20_RS00730	COG0586	Pfam SNARE associated Golgi protein
AOY20_RS00765	COG0321	lipoyl(octanoyl) transferase activity
AOY20_RS00780	COG0531	amino acid
AOY20_RS00800	COG2233	PERMEase
AOY20_RS00805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOY20_RS00810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOY20_RS00810	COG1648	precorrin-2 dehydrogenase activity
AOY20_RS00815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOY20_RS00825	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOY20_RS00830	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOY20_RS00835	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AOY20_RS00850	COG0671	phosphoesterase, PA-phosphatase related
AOY20_RS00855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOY20_RS00865	COG1538	Outer membrane efflux protein
AOY20_RS00870	COG0393	Putative heavy-metal-binding
AOY20_RS00875	COG0393	Putative heavy-metal-binding
AOY20_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS00895	COG0525	valine-tRNA ligase activity
AOY20_RS00925	COG0765	amino acid transport
AOY20_RS00930	COG0765	amino acid transport
AOY20_RS00935	COG1126	abc transporter atp-binding protein
AOY20_RS00955	COG2814	Major facilitator Superfamily
AOY20_RS00965	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOY20_RS00980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOY20_RS00985	COG2205	protein histidine kinase activity
AOY20_RS00990	COG0745	RESPONSE REGULATOR receiver
AOY20_RS00995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOY20_RS00995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOY20_RS01000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOY20_RS01005	COG5290	Psort location Cytoplasmic, score
AOY20_RS01085	COG2132	Multicopper oxidase
AOY20_RS01095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOY20_RS01105	COG4269	membrane
AOY20_RS01130	COG1968	undecaprenyl-diphosphatase activity
AOY20_RS01135	COG1214	PFAM Peptidase M22, glycoprotease
AOY20_RS01145	COG0494	nUDIX hydrolase
AOY20_RS01165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOY20_RS01170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOY20_RS01235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOY20_RS01280	COG0037	tRNA processing
AOY20_RS01290	COG0248	Ppx GppA phosphatase
AOY20_RS01315	COG0072	phenylalanine-tRNA ligase activity
AOY20_RS01330	COG0456	acetyltransferase
AOY20_RS01360	COG1238	metal cluster binding
AOY20_RS01370	COG0625	glutathione transferase activity
AOY20_RS01375	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOY20_RS01395	COG0463	Glycosyl transferase, family 2
AOY20_RS01410	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS01415	COG3028	Belongs to the UPF0307 family
AOY20_RS01420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOY20_RS01425	COG1660	Displays ATPase and GTPase activities
AOY20_RS01440	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOY20_RS01445	COG0617	tRNA 3'-terminal CCA addition
AOY20_RS01450	COG1555	photosystem II stabilization
AOY20_RS01450	COG1596	polysaccharide export
AOY20_RS01455	COG3956	TIGRFAM MazG family protein
AOY20_RS01470	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOY20_RS01490	COG1426	Protein conserved in bacteria
AOY20_RS01510	COG2975	iron-sulfur cluster assembly
AOY20_RS01515	COG1690	Belongs to the RtcB family
AOY20_RS01530	COG0440	acetolactate synthase activity
AOY20_RS01535	COG0028	Belongs to the TPP enzyme family
AOY20_RS01560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOY20_RS01565	COG0577	efflux transmembrane transporter activity
AOY20_RS01565	COG1136	(ABC) transporter
AOY20_RS01570	COG1538	Outer membrane efflux protein
AOY20_RS01620	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOY20_RS01625	COG1162	GTPase activity
AOY20_RS01645	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOY20_RS01655	COG0084	hydrolase, TatD family'
AOY20_RS01665	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOY20_RS01675	COG0793	Belongs to the peptidase S41A family
AOY20_RS01690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOY20_RS01695	COG0857	belongs to the CobB CobQ family
AOY20_RS01695	COG0280	phosphate acetyltransferase
AOY20_RS01725	COG1280	lysine exporter protein (LysE YggA)
AOY20_RS01730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AOY20_RS01730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AOY20_RS01745	COG0740	serine-type endopeptidase activity
AOY20_RS01755	COG4771	TonB-dependent receptor
AOY20_RS01760	COG4771	TonB-dependent receptor
AOY20_RS01765	COG4774	siderophore transport
AOY20_RS01780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOY20_RS01785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOY20_RS01790	COG2813	Specifically methylates the guanine in position
AOY20_RS01790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOY20_RS01805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AOY20_RS01865	COG0583	DNA-binding transcription factor activity
AOY20_RS01915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AOY20_RS01925	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOY20_RS01930	COG3384	dioxygenase
AOY20_RS01935	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS01950	COG4638	Rieske (2fe-2S)
AOY20_RS01955	COG0583	DNA-binding transcription factor activity
AOY20_RS01980	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AOY20_RS01985	COG3971	2-oxopent-4-enoate hydratase activity
AOY20_RS01990	COG0546	phosphoglycolate phosphatase activity
AOY20_RS02000	COG1530	ribonuclease E activity
AOY20_RS02005	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS02035	COG1983	PspC domain protein
AOY20_RS02045	COG0751	glycine-tRNA ligase activity
AOY20_RS02070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOY20_RS02095	COG0493	'glutamate synthase
AOY20_RS02105	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOY20_RS02110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOY20_RS02120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOY20_RS02130	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOY20_RS02130	COG0644	oxidoreductase
AOY20_RS02185	COG0557	exoribonuclease II activity
AOY20_RS02190	COG2720	vancomycin resistance protein
AOY20_RS02200	COG0339	signal peptide processing
AOY20_RS02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AOY20_RS02215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOY20_RS02235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOY20_RS02245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOY20_RS02270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOY20_RS02280	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOY20_RS02285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOY20_RS02335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOY20_RS02350	COG0088	Forms part of the polypeptide exit tunnel
AOY20_RS02375	COG0433	COG0433 Predicted ATPase
AOY20_RS02380	COG1017	nitric oxide dioxygenase activity
AOY20_RS02380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOY20_RS02385	COG1959	2 iron, 2 sulfur cluster binding
AOY20_RS02395	COG1301	dicarboxylic acid transport
AOY20_RS02400	COG1946	Acyl-CoA thioesterase
AOY20_RS02405	COG2937	Belongs to the GPAT DAPAT family
AOY20_RS02415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOY20_RS02420	COG1040	competence protein
AOY20_RS02425	COG0494	nUDIX hydrolase
AOY20_RS02435	COG0598	Magnesium transport protein CorA
AOY20_RS02450	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOY20_RS02455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOY20_RS02460	COG1127	ABC transporter
AOY20_RS02465	COG0513	Belongs to the DEAD box helicase family
AOY20_RS02490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOY20_RS02495	COG0408	coproporphyrinogen oxidase activity
AOY20_RS02515	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS02525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AOY20_RS02535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOY20_RS02545	COG0534	Mate efflux family protein
AOY20_RS02555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOY20_RS02560	COG0254	rRNA binding
AOY20_RS02565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOY20_RS02590	COG1192	Involved in chromosome partitioning
AOY20_RS02595	COG0628	permease
AOY20_RS02600	COG2032	superoxide dismutase activity
AOY20_RS02610	COG2814	Major facilitator Superfamily
AOY20_RS02630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOY20_RS02660	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOY20_RS02660	COG1024	Enoyl-CoA hydratase
AOY20_RS02665	COG0183	Belongs to the thiolase family
AOY20_RS02675	COG2988	succinylglutamate desuccinylase activity
AOY20_RS02680	COG3724	N-succinylarginine dihydrolase activity
AOY20_RS02685	COG1012	belongs to the aldehyde dehydrogenase family
AOY20_RS02690	COG3138	arginine N-succinyltransferase
AOY20_RS02695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOY20_RS02710	COG2233	PERMEase
AOY20_RS02725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOY20_RS02735	COG0326	Molecular chaperone. Has ATPase activity
AOY20_RS02745	COG2056	Na+-H+ antiporter family
AOY20_RS02760	COG0085	RNA polymerase activity
AOY20_RS02770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOY20_RS02775	COG0081	regulation of translation
AOY20_RS02830	COG0546	phosphoglycolate phosphatase activity
AOY20_RS02880	COG0181	hydroxymethylbilane synthase activity
AOY20_RS02925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOY20_RS02935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOY20_RS02940	COG0772	Belongs to the SEDS family
AOY20_RS02965	COG4974	Belongs to the 'phage' integrase family
AOY20_RS02980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOY20_RS02995	COG4191	Histidine kinase
AOY20_RS03005	COG0793	Belongs to the peptidase S41A family
AOY20_RS03010	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOY20_RS03015	COG0795	lipopolysaccharide-transporting ATPase activity
AOY20_RS03020	COG0795	lipopolysaccharide-transporting ATPase activity
AOY20_RS03040	COG0586	Pfam SNARE associated Golgi protein
AOY20_RS03055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOY20_RS03055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOY20_RS03065	COG0004	ammonium transporteR
AOY20_RS03070	COG0347	Belongs to the P(II) protein family
AOY20_RS03080	COG0606	chelatase, subunit chli
AOY20_RS03095	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOY20_RS03110	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS03120	COG0477	Major facilitator Superfamily
AOY20_RS03125	COG2860	membrane
AOY20_RS03135	COG1253	flavin adenine dinucleotide binding
AOY20_RS03160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOY20_RS03165	COG0477	Major facilitator Superfamily
AOY20_RS03235	COG0758	DNA mediated transformation
AOY20_RS03245	COG0697	spore germination
AOY20_RS03250	COG0386	Belongs to the glutathione peroxidase family
AOY20_RS03285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOY20_RS03325	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AOY20_RS03330	COG0735	belongs to the Fur family
AOY20_RS03335	COG1121	(ABC) transporter
AOY20_RS03340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOY20_RS03355	COG2837	iron assimilation
AOY20_RS03370	COG3179	chitinase
AOY20_RS03380	COG0281	malic enzyme
AOY20_RS03410	COG0519	Catalyzes the synthesis of GMP from XMP
AOY20_RS03410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOY20_RS03420	COG2259	Doxx family
AOY20_RS03425	COG0586	Pfam SNARE associated Golgi protein
AOY20_RS03480	COG3756	Protein conserved in bacteria
AOY20_RS03500	COG0419	ATPase involved in DNA repair
AOY20_RS03565	COG0679	Auxin Efflux Carrier
AOY20_RS03570	COG0786	glutamate:sodium symporter activity
AOY20_RS03605	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOY20_RS03610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AOY20_RS03640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOY20_RS03650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOY20_RS03655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOY20_RS03660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOY20_RS03665	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOY20_RS03670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOY20_RS03675	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOY20_RS03690	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOY20_RS03700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOY20_RS03710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOY20_RS03715	COG0438	transferase activity, transferring glycosyl groups
AOY20_RS03720	COG0438	transferase activity, transferring glycosyl groups
AOY20_RS03725	COG0438	transferase activity, transferring glycosyl groups
AOY20_RS03740	COG0110	maltose O-acetyltransferase activity
AOY20_RS03755	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOY20_RS03760	COG1596	polysaccharide export
AOY20_RS03775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOY20_RS03800	COG2233	PERMEase
AOY20_RS03815	COG0546	phosphoglycolate phosphatase activity
AOY20_RS03830	COG0129	dihydroxy-acid dehydratase activity
AOY20_RS03850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOY20_RS03855	COG0733	neurotransmitter:sodium symporter activity
AOY20_RS03860	COG3738	Protein conserved in bacteria
AOY20_RS03875	COG2814	Major facilitator Superfamily
AOY20_RS03905	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOY20_RS03910	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOY20_RS03925	COG0488	(ABC) transporter
AOY20_RS03935	COG0187	DNA topoisomerase II activity
AOY20_RS03945	COG0592	DNA-directed DNA polymerase activity
AOY20_RS03950	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOY20_RS03965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AOY20_RS03980	COG3188	usher protein
AOY20_RS03985	COG3121	Chaperone
AOY20_RS04010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOY20_RS04025	COG0402	S-adenosylhomocysteine deaminase activity
AOY20_RS04035	COG0861	Integral membrane protein TerC family
AOY20_RS04040	COG2814	Major facilitator Superfamily
AOY20_RS04055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOY20_RS04070	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AOY20_RS04075	COG2951	lytic endotransglycosylase activity
AOY20_RS04095	COG3188	usher protein
AOY20_RS04100	COG3121	Chaperone
AOY20_RS04120	COG0657	acetylesterase activity
AOY20_RS04125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOY20_RS04155	COG2133	pyrroloquinoline quinone binding
AOY20_RS04160	COG1283	sodium-dependent phosphate transmembrane transporter activity
AOY20_RS04175	COG2453	phosphatase
AOY20_RS04175	COG0671	phosphoesterase, PA-phosphatase related
AOY20_RS04180	COG2267	carboxylic ester hydrolase activity
AOY20_RS04185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AOY20_RS04200	COG1047	Peptidyl-prolyl cis-trans
AOY20_RS04210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOY20_RS04215	COG0196	riboflavin kinase activity
AOY20_RS04220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOY20_RS04225	COG1309	transcriptional regulator
AOY20_RS04230	COG1116	anion transmembrane transporter activity
AOY20_RS04235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOY20_RS04240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOY20_RS04245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOY20_RS04250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOY20_RS04255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOY20_RS04255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOY20_RS04275	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS04280	COG0546	phosphoglycolate phosphatase activity
AOY20_RS04285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOY20_RS04300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOY20_RS04310	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOY20_RS04325	COG0545	Peptidyl-prolyl cis-trans isomerase
AOY20_RS04345	COG2818	Glycosylase
AOY20_RS04355	COG0739	heme binding
AOY20_RS04360	COG1194	a g-specific adenine glycosylase
AOY20_RS04375	COG2983	Belongs to the UPF0260 family
AOY20_RS04380	COG1683	Conserved Protein
AOY20_RS04385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOY20_RS04390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOY20_RS04400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOY20_RS04405	COG2814	Major facilitator Superfamily
AOY20_RS04410	COG1335	isochorismatase
AOY20_RS04415	COG0385	Bile acid
AOY20_RS04425	COG0560	Phosphoserine phosphatase
AOY20_RS04425	COG3830	Belongs to the UPF0237 family
AOY20_RS04445	COG0753	catalase activity
AOY20_RS04485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOY20_RS04495	COG0534	Mate efflux family protein
AOY20_RS04500	COG0436	Aminotransferase
AOY20_RS04505	COG2733	membrane
AOY20_RS04520	COG2918	glutathione biosynthetic process
AOY20_RS04525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOY20_RS04535	COG3150	esterase
AOY20_RS04565	COG0410	ABC transporter
AOY20_RS04590	COG0784	Response regulator, receiver
AOY20_RS04590	COG2205	protein histidine kinase activity
AOY20_RS04605	COG4266	Belongs to the allantoicase family
AOY20_RS04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOY20_RS04615	COG1247	-acetyltransferase
AOY20_RS04625	COG2351	hydroxyisourate hydrolase activity
AOY20_RS04670	COG1393	Belongs to the ArsC family
AOY20_RS04675	COG0708	Exodeoxyribonuclease III
AOY20_RS04680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AOY20_RS04685	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS04690	COG1309	transcriptional regulator
AOY20_RS04695	COG0666	response to abiotic stimulus
AOY20_RS04715	COG0402	S-adenosylhomocysteine deaminase activity
AOY20_RS04730	COG0189	ligase activity
AOY20_RS04740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOY20_RS04745	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOY20_RS04750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOY20_RS04765	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOY20_RS04790	COG2119	membrane
AOY20_RS04810	COG0259	pyridoxamine-phosphate oxidase activity
AOY20_RS04815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOY20_RS04835	COG1902	pentaerythritol trinitrate reductase activity
AOY20_RS04840	COG1519	Transferase
AOY20_RS04850	COG0668	transmembrane transport
AOY20_RS04855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOY20_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS04880	COG2851	Citrate transporter
AOY20_RS04890	COG0307	riboflavin synthase, alpha
AOY20_RS04900	COG0431	NADPH-dependent FMN reductase
AOY20_RS04915	COG0784	Response regulator, receiver
AOY20_RS04915	COG2198	Histidine kinase
AOY20_RS04915	COG2205	protein histidine kinase activity
AOY20_RS04920	COG3162	membrane
AOY20_RS04925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOY20_RS04930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOY20_RS04960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOY20_RS04960	COG0352	thiamine-phosphate diphosphorylase activity
AOY20_RS04960	COG0351	phosphomethylpyrimidine kinase
AOY20_RS04970	COG2814	Major facilitator Superfamily
AOY20_RS04975	COG0629	single-stranded DNA binding
AOY20_RS04995	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AOY20_RS05015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOY20_RS05030	COG3158	transport of potassium into the cell
AOY20_RS05045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOY20_RS05060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOY20_RS05065	COG1278	Cold shock
AOY20_RS05075	COG0697	spore germination
AOY20_RS05090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOY20_RS05115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOY20_RS05125	COG0427	acetyl-CoA hydrolase
AOY20_RS05150	COG4221	oxidoreductase activity
AOY20_RS05155	COG2873	o-acetylhomoserine
AOY20_RS05160	COG0488	(ABC) transporter
AOY20_RS05195	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOY20_RS05215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOY20_RS05220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOY20_RS05225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOY20_RS05230	COG2226	methyltransferase
AOY20_RS05280	COG0069	glutamate synthase activity
AOY20_RS05280	COG0067	glutamate synthase
AOY20_RS05280	COG0070	glutamate synthase
AOY20_RS05285	COG0493	'glutamate synthase
AOY20_RS05290	COG1704	LemA family
AOY20_RS05310	COG3307	-O-antigen
AOY20_RS05330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOY20_RS05335	COG1758	RNA polymerase activity
AOY20_RS05340	COG0194	GDP metabolic process
AOY20_RS05350	COG4969	Belongs to the N-Me-Phe pilin family
AOY20_RS05375	COG4969	Belongs to the N-Me-Phe pilin family
AOY20_RS05385	COG0228	four-way junction DNA binding
AOY20_RS05390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOY20_RS05400	COG0335	large ribosomal subunit rRNA binding
AOY20_RS05405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AOY20_RS05410	COG5380	lipid catabolic process
AOY20_RS05415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOY20_RS05430	COG5006	permease, DMT superfamily
AOY20_RS05435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOY20_RS05440	COG0277	FAD linked oxidase domain protein
AOY20_RS05455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOY20_RS05470	COG0497	DNA recombination
AOY20_RS05475	COG3123	guanosine phosphorylase activity
AOY20_RS05480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOY20_RS05490	COG0237	dephospho-CoA kinase activity
AOY20_RS05545	COG0779	Required for maturation of 30S ribosomal subunits
AOY20_RS05550	COG0195	Participates in both transcription termination and antitermination
AOY20_RS05560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOY20_RS05570	COG1320	monovalent cation:proton antiporter activity
AOY20_RS05575	COG2212	antiporter activity
AOY20_RS05580	COG1863	multisubunit Na H antiporter MnhE subunit
AOY20_RS05585	COG0651	ATP synthesis coupled electron transport
AOY20_RS05590	COG1006	Multisubunit Na H antiporter MnhC subunit
AOY20_RS05595	COG2111	Na H antiporter
AOY20_RS05595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOY20_RS05610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOY20_RS05630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOY20_RS05660	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOY20_RS05665	COG1074	ATP-dependent DNA helicase activity
AOY20_RS05670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOY20_RS05675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOY20_RS05680	COG1185	polyribonucleotide nucleotidyltransferase activity
AOY20_RS05685	COG2841	Protein conserved in bacteria
AOY20_RS05690	COG2841	Protein conserved in bacteria
AOY20_RS05705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOY20_RS05715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOY20_RS05725	COG2165	general secretion pathway protein
AOY20_RS05740	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOY20_RS05770	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AOY20_RS05785	COG0473	3-isopropylmalate dehydrogenase activity
AOY20_RS05805	COG0252	asparaginase activity
AOY20_RS05835	COG1560	Kdo2-lipid A biosynthetic process
AOY20_RS05840	COG0488	(ABC) transporter
AOY20_RS05845	COG2900	Belongs to the SlyX family
AOY20_RS05875	COG1929	Belongs to the glycerate kinase type-1 family
AOY20_RS05880	COG0210	DNA helicase
AOY20_RS05925	COG0788	formyltetrahydrofolate deformylase activity
AOY20_RS05955	COG0697	spore germination
AOY20_RS05960	COG1295	ribonuclease BN
AOY20_RS05995	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS06025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOY20_RS06030	COG1702	phosphate starvation-inducible protein PhoH
AOY20_RS06035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOY20_RS06040	COG0739	heme binding
AOY20_RS06040	COG0741	lytic transglycosylase activity
AOY20_RS06040	COG1196	nuclear chromosome segregation
AOY20_RS06070	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOY20_RS06075	COG1183	phosphatidylcholine synthase activity
AOY20_RS06110	COG2814	Major facilitator Superfamily
AOY20_RS06140	COG1607	acyl-coa hydrolase
AOY20_RS06155	COG1666	GTP binding
AOY20_RS06175	COG2350	Protein conserved in bacteria
AOY20_RS06195	COG3781	membrane
AOY20_RS06205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOY20_RS06210	COG4589	Belongs to the CDS family
AOY20_RS06220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOY20_RS06225	COG2814	Major facilitator Superfamily
AOY20_RS06260	COG3622	Belongs to the hyi family
AOY20_RS06265	COG2084	Dehydrogenase
AOY20_RS06270	COG1024	Enoyl-CoA hydratase
AOY20_RS06275	COG5002	protein histidine kinase activity
AOY20_RS06275	COG0784	Response regulator, receiver
AOY20_RS06275	COG2205	protein histidine kinase activity
AOY20_RS06295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOY20_RS06310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOY20_RS06315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOY20_RS06325	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS06330	COG0463	Glycosyl transferase, family 2
AOY20_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS06400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOY20_RS06410	COG1862	Preprotein translocase
AOY20_RS06425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOY20_RS06435	COG5002	protein histidine kinase activity
AOY20_RS06440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOY20_RS06480	COG1216	Glycosyl transferase, family 2
AOY20_RS06485	COG3306	glycosyltransferase involved in LPS biosynthesis
AOY20_RS06505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOY20_RS06540	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS06545	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS06555	COG2205	protein histidine kinase activity
AOY20_RS06560	COG0745	RESPONSE REGULATOR receiver
AOY20_RS06565	COG2315	Protein conserved in bacteria
AOY20_RS06570	COG0456	acetyltransferase
AOY20_RS06585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOY20_RS06605	COG2096	Adenosyltransferase
AOY20_RS06610	COG4206	TonB-dependent receptor
AOY20_RS06635	COG3083	sulfuric ester hydrolase activity
AOY20_RS06650	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOY20_RS06655	COG0285	dihydrofolate synthase activity
AOY20_RS06670	COG0653	protein targeting
AOY20_RS06680	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOY20_RS06685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOY20_RS06710	COG2885	chlorophyll binding
AOY20_RS06715	COG2199	diguanylate cyclase activity
AOY20_RS06755	COG2969	positive regulation of protein catabolic process
AOY20_RS06760	COG0625	glutathione transferase activity
AOY20_RS06765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOY20_RS06770	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOY20_RS06775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOY20_RS06780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOY20_RS06785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOY20_RS06805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOY20_RS06815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOY20_RS06820	COG1408	metallophosphoesterase
AOY20_RS06825	COG0477	Major facilitator Superfamily
AOY20_RS06830	COG1272	protein, Hemolysin III
AOY20_RS06855	COG2186	Transcriptional regulator
AOY20_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS06870	COG4948	Mandelate Racemase Muconate Lactonizing
AOY20_RS06875	COG2271	Major facilitator Superfamily
AOY20_RS06880	COG3152	Membrane
AOY20_RS06885	COG0351	phosphomethylpyrimidine kinase
AOY20_RS06885	COG0352	thiamine-phosphate diphosphorylase activity
AOY20_RS06885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOY20_RS06905	COG1113	amino acid transport
AOY20_RS06910	COG1981	membrane
AOY20_RS06925	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOY20_RS06945	COG0456	acetyltransferase
AOY20_RS06955	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOY20_RS06960	COG0500	methyltransferase
AOY20_RS06965	COG0492	ferredoxin-NADP+ reductase activity
AOY20_RS06970	COG1674	ftsk spoiiie
AOY20_RS06970	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOY20_RS06995	COG0850	regulation of cytokinetic process
AOY20_RS07005	COG0204	Acyl-transferase
AOY20_RS07010	COG2885	chlorophyll binding
AOY20_RS07015	COG0210	DNA helicase
AOY20_RS07020	COG0756	dUTP diphosphatase activity
AOY20_RS07025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOY20_RS07030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOY20_RS07035	COG0121	glutamine amidotransferase
AOY20_RS07050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOY20_RS07055	COG0735	belongs to the Fur family
AOY20_RS07080	COG0420	3'-5' exonuclease activity
AOY20_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOY20_RS07105	COG2050	protein possibly involved in aromatic compounds catabolism
AOY20_RS07110	COG1566	PFAM secretion protein HlyD family protein
AOY20_RS07115	COG2814	Major facilitator Superfamily
AOY20_RS07120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOY20_RS07145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOY20_RS07160	COG2271	Major facilitator Superfamily
AOY20_RS07170	COG1414	Transcriptional regulator
AOY20_RS07175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOY20_RS07180	COG1414	Transcriptional regulator
AOY20_RS07185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOY20_RS07190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOY20_RS07195	COG0183	Belongs to the thiolase family
AOY20_RS07200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AOY20_RS07205	COG0596	Alpha beta hydrolase
AOY20_RS07210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOY20_RS07215	COG3485	protocatechuate 3,4-dioxygenase
AOY20_RS07220	COG3485	protocatechuate 3,4-dioxygenase
AOY20_RS07240	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS07245	COG3320	Male sterility
AOY20_RS07245	COG1022	Amp-dependent synthetase and ligase
AOY20_RS07250	COG1012	belongs to the aldehyde dehydrogenase family
AOY20_RS07255	COG1024	Enoyl-CoA hydratase
AOY20_RS07260	COG2814	Major facilitator Superfamily
AOY20_RS07275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOY20_RS07310	COG2207	Transcriptional regulator
AOY20_RS07315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOY20_RS07325	COG0183	Belongs to the thiolase family
AOY20_RS07345	COG0833	amino acid
AOY20_RS07355	COG2233	PERMEase
AOY20_RS07360	COG1217	gtp-binding protein TYPA
AOY20_RS07365	COG1970	mechanosensitive ion channel activity
AOY20_RS07375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOY20_RS07390	COG1902	pentaerythritol trinitrate reductase activity
AOY20_RS07395	COG0679	Auxin Efflux Carrier
AOY20_RS07400	COG1953	Uracil, thiamine, allantoin
AOY20_RS07410	COG0354	folic acid binding
AOY20_RS07455	COG2824	Alkylphosphonate utilization operon protein PhnA
AOY20_RS07490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AOY20_RS07495	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOY20_RS07525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOY20_RS07540	COG0358	DNA primase activity
AOY20_RS07550	COG0564	pseudouridine synthase activity
AOY20_RS07565	COG1113	amino acid transport
AOY20_RS07570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOY20_RS07580	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOY20_RS07595	COG2226	methyltransferase
AOY20_RS07595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOY20_RS07595	COG0596	Alpha beta hydrolase
AOY20_RS07610	COG4106	trans-aconitate 2-methyltransferase activity
AOY20_RS07625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOY20_RS07630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOY20_RS07640	COG0009	L-threonylcarbamoyladenylate synthase
AOY20_RS07645	COG3101	peptidyl-lysine hydroxylation
AOY20_RS07650	COG1399	metal-binding, possibly nucleic acid-binding protein
AOY20_RS07655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOY20_RS07665	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS07680	COG0589	response to stress
AOY20_RS07685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOY20_RS07700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOY20_RS07700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOY20_RS07705	COG3397	chitin binding
AOY20_RS07710	COG3397	chitin binding
AOY20_RS07725	COG0489	protein tyrosine kinase activity
AOY20_RS07740	COG2358	TRAP transporter, solute receptor (TAXI family
AOY20_RS07755	COG0442	prolyl-tRNA aminoacylation
AOY20_RS07795	COG2832	Protein of unknown function (DUF454)
AOY20_RS07860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOY20_RS07870	COG1289	transmembrane transporter activity
AOY20_RS07880	COG0786	glutamate:sodium symporter activity
AOY20_RS07885	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOY20_RS07890	COG1607	acyl-coa hydrolase
AOY20_RS07905	COG2814	Major facilitator Superfamily
AOY20_RS07910	COG0583	DNA-binding transcription factor activity
AOY20_RS07930	COG0523	cobalamin synthesis protein
AOY20_RS07935	COG4681	YaeQ
AOY20_RS07970	COG1741	Belongs to the pirin family
AOY20_RS07985	COG3739	integral membrane protein
AOY20_RS07995	COG0302	gtp cyclohydrolase
AOY20_RS08015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOY20_RS08020	COG0512	Glutamine amidotransferase of anthranilate synthase
AOY20_RS08035	COG3209	COG3209 Rhs family protein
AOY20_RS08045	COG3209	COG3209 Rhs family protein
AOY20_RS08065	COG0174	glutamine synthetase
AOY20_RS08085	COG3161	chorismate lyase activity
AOY20_RS08090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOY20_RS08110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOY20_RS08125	COG3539	Fimbrial protein
AOY20_RS08130	COG3539	Fimbrial protein
AOY20_RS08135	COG3188	usher protein
AOY20_RS08145	COG3539	Fimbrial protein
AOY20_RS08160	COG2268	Band 7 protein
AOY20_RS08200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOY20_RS08205	COG0604	alcohol dehydrogenase
AOY20_RS08205	COG3321	synthase
AOY20_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS08215	COG2851	Citrate transporter
AOY20_RS08220	COG1253	flavin adenine dinucleotide binding
AOY20_RS08265	COG0804	urea catabolic process
AOY20_RS08285	COG0830	nickel cation binding
AOY20_RS08315	COG0742	ribosomal rna small subunit methyltransferase
AOY20_RS08320	COG0768	penicillin binding
AOY20_RS08340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOY20_RS08345	COG2878	Part of a membrane complex involved in electron transport
AOY20_RS08350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOY20_RS08360	COG3384	dioxygenase
AOY20_RS08365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOY20_RS08370	COG2234	aminopeptidase activity
AOY20_RS08380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOY20_RS08385	COG1733	regulation of RNA biosynthetic process
AOY20_RS08390	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOY20_RS08400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AOY20_RS08415	COG0583	DNA-binding transcription factor activity
AOY20_RS08425	COG1346	cytolysis
AOY20_RS08430	COG0671	phosphoesterase, PA-phosphatase related
AOY20_RS08440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOY20_RS08445	COG0076	glutamate decarboxylase activity
AOY20_RS08455	COG0573	inorganic phosphate transmembrane transporter activity
AOY20_RS08465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOY20_RS08470	COG0765	amino acid transport
AOY20_RS08475	COG0765	amino acid transport
AOY20_RS08480	COG1126	abc transporter atp-binding protein
AOY20_RS08485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOY20_RS08490	COG0616	signal peptide processing
AOY20_RS08520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOY20_RS08525	COG1686	Belongs to the peptidase S11 family
AOY20_RS08535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOY20_RS08545	COG0583	DNA-binding transcription factor activity
AOY20_RS08550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOY20_RS08555	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOY20_RS08560	COG1067	ATP-dependent peptidase activity
AOY20_RS08595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOY20_RS08600	COG1966	Carbon starvation protein
AOY20_RS08605	COG2879	small protein
AOY20_RS08725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOY20_RS08725	COG0189	ligase activity
AOY20_RS08765	COG0667	Aldo Keto reductase
AOY20_RS08775	COG1765	OsmC-like protein
AOY20_RS08785	COG0116	Belongs to the methyltransferase superfamily
AOY20_RS08785	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOY20_RS08790	COG1686	Belongs to the peptidase S11 family
AOY20_RS08815	COG4935	Belongs to the peptidase S8 family
AOY20_RS08815	COG1404	Belongs to the peptidase S8 family
AOY20_RS08830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOY20_RS08850	COG3634	alkyl hydroperoxide reductase activity
AOY20_RS08855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOY20_RS08860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOY20_RS08885	COG1944	ATP diphosphatase activity
AOY20_RS08905	COG3188	usher protein
AOY20_RS08920	COG3121	Chaperone
AOY20_RS08925	COG3188	usher protein
AOY20_RS08945	COG0052	Belongs to the universal ribosomal protein uS2 family
AOY20_RS08980	COG2951	lytic endotransglycosylase activity
AOY20_RS08985	COG0772	Belongs to the SEDS family
AOY20_RS09000	COG0842	Transport permease protein
AOY20_RS09005	COG1131	(ABC) transporter
AOY20_RS09015	COG0582	viral genome integration into host DNA
AOY20_RS09050	COG0305	Participates in initiation and elongation during chromosome replication
AOY20_RS09135	COG0582	viral genome integration into host DNA
AOY20_RS09220	COG1309	transcriptional regulator
AOY20_RS09225	COG1335	isochorismatase
AOY20_RS09235	COG0640	Transcriptional regulator
AOY20_RS09240	COG0798	PFAM Bile acid sodium symporter
AOY20_RS09245	COG0431	NADPH-dependent FMN reductase
AOY20_RS09275	COG1560	Kdo2-lipid A biosynthetic process
AOY20_RS09285	COG3561	AntA/AntB antirepressor
AOY20_RS09360	COG1278	Cold shock
AOY20_RS09375	COG2197	response regulator
AOY20_RS09380	COG3850	Histidine kinase
AOY20_RS09385	COG0315	cyclic pyranopterin monophosphate synthase activity
AOY20_RS09395	COG0314	molybdopterin synthase activity
AOY20_RS09400	COG0746	molybdenum cofactor guanylyltransferase activity
AOY20_RS09405	COG0303	'Molybdopterin
AOY20_RS09410	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOY20_RS09415	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOY20_RS09420	COG4149	molybdate abc transporter
AOY20_RS09425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOY20_RS09465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOY20_RS09475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOY20_RS09480	COG2181	nitrate reductase activity
AOY20_RS09485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AOY20_RS09490	COG1140	nitrate reductase beta subunit
AOY20_RS09495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AOY20_RS09500	COG2223	nitrite transmembrane transporter activity
AOY20_RS09545	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AOY20_RS09555	COG3079	Belongs to the UPF0149 family
AOY20_RS09560	COG0006	proline dipeptidase activity
AOY20_RS09565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOY20_RS09570	COG0842	Transport permease protein
AOY20_RS09570	COG1129	ABC transporter
AOY20_RS09575	COG0842	Transport permease protein
AOY20_RS09585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOY20_RS09590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOY20_RS09635	COG3210	domain, Protein
AOY20_RS09645	COG0736	holo-[acyl-carrier-protein] synthase activity
AOY20_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS09655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOY20_RS09665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AOY20_RS09670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOY20_RS09695	COG2177	Part of the ABC transporter FtsEX involved in
AOY20_RS09720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOY20_RS09725	COG1388	LysM domain
AOY20_RS09725	COG0741	lytic transglycosylase activity
AOY20_RS09730	COG4166	transmembrane transport
AOY20_RS09735	COG4174	ABC transporter (Permease)
AOY20_RS09745	COG4172	Belongs to the ABC transporter superfamily
AOY20_RS09780	COG4783	chaperone-mediated protein folding
AOY20_RS09790	COG1610	YqeY-like protein
AOY20_RS09855	COG2011	ABC-type metal ion transport system permease component
AOY20_RS09860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOY20_RS09870	COG0151	Belongs to the GarS family
AOY20_RS09875	COG0138	bifunctional purine biosynthesis protein purh
AOY20_RS09880	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOY20_RS09905	COG0445	tRNA wobble uridine modification
AOY20_RS09915	COG2814	Major facilitator Superfamily
AOY20_RS09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOY20_RS09930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOY20_RS09935	COG2890	protein-(glutamine-N5) methyltransferase activity
AOY20_RS09945	COG2814	Major facilitator Superfamily
AOY20_RS09955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOY20_RS10080	COG1720	tRNA m6t6A37 methyltransferase activity
AOY20_RS10105	COG0642	Histidine kinase
AOY20_RS10115	COG0494	nUDIX hydrolase
AOY20_RS10125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOY20_RS10130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOY20_RS10135	COG3139	Protein of unknown function (DUF1315)
AOY20_RS10140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOY20_RS10145	COG1301	dicarboxylic acid transport
AOY20_RS10155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOY20_RS10160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOY20_RS10205	COG0612	Peptidase, M16
AOY20_RS10225	COG0352	thiamine-phosphate diphosphorylase activity
AOY20_RS10235	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AOY20_RS10310	COG2076	Multidrug Resistance protein
AOY20_RS10320	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AOY20_RS10325	COG3713	MltA-interacting MipA family protein
AOY20_RS10330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOY20_RS10345	COG0028	Belongs to the TPP enzyme family
AOY20_RS10365	COG1218	3'(2'),5'-bisphosphate nucleotidase
AOY20_RS10385	COG0702	epimerase
AOY20_RS10390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOY20_RS10410	COG2353	YceI-like domain
AOY20_RS10420	COG0439	Biotin carboxylase
AOY20_RS10425	COG0511	ligase activity, forming carbon-carbon bonds
AOY20_RS10450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOY20_RS10455	COG0730	response to heat
AOY20_RS10460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOY20_RS10465	COG0183	Belongs to the thiolase family
AOY20_RS10470	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS10500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOY20_RS10520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOY20_RS10530	COG0133	tryptophan synthase activity
AOY20_RS10535	COG0517	IMP dehydrogenase activity
AOY20_RS10560	COG0552	protein localization to endoplasmic reticulum
AOY20_RS10625	COG0372	Belongs to the citrate synthase family
AOY20_RS10650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOY20_RS10660	COG0505	Belongs to the CarA family
AOY20_RS10670	COG1278	Cold shock
AOY20_RS10675	COG0668	transmembrane transport
AOY20_RS10685	COG2070	2-Nitropropane dioxygenase
AOY20_RS10695	COG2391	methyltransferase activity
AOY20_RS10700	COG1301	dicarboxylic acid transport
AOY20_RS10725	COG1643	Atp-dependent helicase
AOY20_RS10750	COG2707	UPF0756 membrane protein
AOY20_RS10775	COG0802	atpase or kinase
AOY20_RS10780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOY20_RS10790	COG1923	regulation of RNA biosynthetic process
AOY20_RS10795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOY20_RS10810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOY20_RS10820	COG1192	Involved in chromosome partitioning
AOY20_RS10825	COG1475	DNA binding
AOY20_RS10830	COG1132	(ABC) transporter
AOY20_RS10835	COG1663	tetraacyldisaccharide 4'-kinase activity
AOY20_RS10855	COG0084	hydrolase, TatD family'
AOY20_RS10890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOY20_RS10925	COG0284	orotidine-5'-phosphate decarboxylase activity
AOY20_RS10955	COG3122	Protein conserved in bacteria
AOY20_RS10980	COG2937	Belongs to the GPAT DAPAT family
AOY20_RS10985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOY20_RS11000	COG3121	Chaperone
AOY20_RS11005	COG3188	usher protein
AOY20_RS11015	COG3121	Chaperone
AOY20_RS11020	COG2207	Transcriptional regulator
AOY20_RS11040	COG0308	aminopeptidase N
AOY20_RS11050	COG0589	response to stress
AOY20_RS11060	COG3135	benzoate transporter
AOY20_RS11070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOY20_RS11090	COG2814	Major facilitator Superfamily
AOY20_RS11125	COG1294	oxidase, subunit
AOY20_RS11150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOY20_RS11155	COG2153	protein acetylation
AOY20_RS11170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOY20_RS11175	COG0569	domain protein
AOY20_RS11195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOY20_RS11250	COG1522	sequence-specific DNA binding
AOY20_RS11260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOY20_RS11265	COG0183	Belongs to the thiolase family
AOY20_RS11270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOY20_RS11275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOY20_RS11280	COG3135	benzoate transporter
AOY20_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS11290	COG0633	Ferredoxin
AOY20_RS11290	COG0543	2 iron, 2 sulfur cluster binding
AOY20_RS11295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AOY20_RS11300	COG4638	Rieske (2fe-2S)
AOY20_RS11310	COG4829	muconolactone delta-isomerase
AOY20_RS11315	COG4948	Mandelate Racemase Muconate Lactonizing
AOY20_RS11320	COG0583	DNA-binding transcription factor activity
AOY20_RS11325	COG2814	Major facilitator Superfamily
AOY20_RS11345	COG1064	alcohol dehydrogenase
AOY20_RS11350	COG0786	glutamate:sodium symporter activity
AOY20_RS11355	COG0583	DNA-binding transcription factor activity
AOY20_RS11365	COG0251	oxidation-reduction process
AOY20_RS11400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AOY20_RS11410	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS11420	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS11425	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS11430	COG4628	conserved protein (DUF2132)
AOY20_RS11435	COG0644	oxidoreductase
AOY20_RS11435	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOY20_RS11445	COG0583	DNA-binding transcription factor activity
AOY20_RS11455	COG2814	Major facilitator Superfamily
AOY20_RS11470	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS11475	COG2814	Major facilitator Superfamily
AOY20_RS11480	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS11495	COG1607	acyl-coa hydrolase
AOY20_RS11500	COG0183	Belongs to the thiolase family
AOY20_RS11505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOY20_RS11510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AOY20_RS11520	COG4772	TonB-dependent receptor
AOY20_RS11535	COG3008	intermembrane lipid transfer
AOY20_RS11535	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOY20_RS11540	COG2995	paraquat-inducible protein a
AOY20_RS11565	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS11570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOY20_RS11575	COG0596	Alpha beta hydrolase
AOY20_RS11600	COG0542	response to heat
AOY20_RS11605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOY20_RS11615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AOY20_RS11620	COG5001	Diguanylate cyclase
AOY20_RS11620	COG3300	MHYT domain
AOY20_RS11630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AOY20_RS11635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOY20_RS11645	COG2850	peptidyl-arginine hydroxylation
AOY20_RS11650	COG0069	glutamate synthase activity
AOY20_RS11670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOY20_RS11675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOY20_RS11685	COG0668	transmembrane transport
AOY20_RS11690	COG1132	(ABC) transporter
AOY20_RS11700	COG0509	glycine decarboxylation via glycine cleavage system
AOY20_RS11705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOY20_RS11720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOY20_RS11765	COG3188	usher protein
AOY20_RS11770	COG3121	Chaperone
AOY20_RS11775	COG3539	Fimbrial protein
AOY20_RS11785	COG1027	Aspartate ammonia-lyase
AOY20_RS11790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOY20_RS11800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOY20_RS11800	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOY20_RS11800	COG0506	proline dehydrogenase activity
AOY20_RS11825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOY20_RS11835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOY20_RS11855	COG0778	Nitroreductase
AOY20_RS11860	COG0697	spore germination
AOY20_RS11875	COG0126	phosphoglycerate kinase activity
AOY20_RS11885	COG0424	maF-like protein
AOY20_RS11895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOY20_RS11910	COG0772	Belongs to the SEDS family
AOY20_RS11925	COG0148	phosphopyruvate hydratase activity
AOY20_RS11945	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOY20_RS11945	COG1902	pentaerythritol trinitrate reductase activity
AOY20_RS11955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOY20_RS11990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOY20_RS11995	COG0776	regulation of translation
AOY20_RS12020	COG0822	iron-sulfur transferase activity
AOY20_RS12025	COG0316	Belongs to the HesB IscA family
AOY20_RS12055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOY20_RS12085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOY20_RS12120	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOY20_RS12125	COG1136	(ABC) transporter
AOY20_RS12130	COG1011	Hydrolase
AOY20_RS12135	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOY20_RS12145	COG2137	regulation of response to DNA damage stimulus
AOY20_RS12155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOY20_RS12165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOY20_RS12175	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOY20_RS12190	COG0575	Belongs to the CDS family
AOY20_RS12195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOY20_RS12200	COG0233	cytoplasmic translational termination
AOY20_RS12215	COG3852	Histidine kinase
AOY20_RS12220	COG2204	response regulator
AOY20_RS12230	COG0583	DNA-binding transcription factor activity
AOY20_RS12235	COG0024	Methionine aminopeptidase
AOY20_RS12240	COG1114	Component of the transport system for branched-chain amino acids
AOY20_RS12255	COG1253	flavin adenine dinucleotide binding
AOY20_RS12260	COG1846	Transcriptional regulator
AOY20_RS12265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOY20_RS12275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOY20_RS12285	COG2431	L-lysine efflux transmembrane transporter activity
AOY20_RS12295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOY20_RS12305	COG0583	DNA-binding transcription factor activity
AOY20_RS12315	COG5383	Protein conserved in bacteria
AOY20_RS12320	COG2095	MarC family integral membrane protein
AOY20_RS12335	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS12340	COG0318	PFAM AMP-dependent synthetase and ligase
AOY20_RS12345	COG1024	Enoyl-CoA hydratase
AOY20_RS12345	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOY20_RS12350	COG2814	Major facilitator Superfamily
AOY20_RS12360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOY20_RS12365	COG2326	polyphosphate kinase activity
AOY20_RS12380	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOY20_RS12385	COG0010	Belongs to the arginase family
AOY20_RS12430	COG3210	domain, Protein
AOY20_RS12435	COG3210	domain, Protein
AOY20_RS12440	COG1733	regulation of RNA biosynthetic process
AOY20_RS12495	COG1464	Belongs to the NlpA lipoprotein family
AOY20_RS12505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOY20_RS12510	COG2011	ABC-type metal ion transport system permease component
AOY20_RS12515	COG0012	GTP binding
AOY20_RS12520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOY20_RS12535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOY20_RS12560	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AOY20_RS12565	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOY20_RS12575	COG4716	Myosin-crossreactive antigen
AOY20_RS12580	COG0386	Belongs to the glutathione peroxidase family
AOY20_RS12585	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOY20_RS12590	COG0436	Aminotransferase
AOY20_RS12650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOY20_RS12660	COG4122	O-methyltransferase activity
AOY20_RS12695	COG1137	ATPase activity
AOY20_RS12700	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOY20_RS12710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOY20_RS12715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AOY20_RS12715	COG0517	IMP dehydrogenase activity
AOY20_RS12720	COG0471	metal ion transport
AOY20_RS12735	COG2072	flavoprotein involved in K transport
AOY20_RS12760	COG5285	phytanoyl-CoA dioxygenase
AOY20_RS12770	COG1126	abc transporter atp-binding protein
AOY20_RS12775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOY20_RS12840	COG0729	surface antigen
AOY20_RS12845	COG0477	Major facilitator Superfamily
AOY20_RS12860	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOY20_RS12860	COG1902	pentaerythritol trinitrate reductase activity
AOY20_RS12865	COG0277	FAD linked oxidase domain protein
AOY20_RS12875	COG2186	Transcriptional regulator
AOY20_RS12880	COG1620	l-lactate permease
AOY20_RS12890	COG0418	dihydroorotase activity
AOY20_RS12895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOY20_RS12905	COG4771	TonB-dependent receptor
AOY20_RS12915	COG0833	amino acid
AOY20_RS12930	COG0501	Belongs to the peptidase M48B family
AOY20_RS12945	COG0167	dihydroorotate dehydrogenase activity
AOY20_RS12965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOY20_RS12970	COG0778	Nitroreductase
AOY20_RS12980	COG0513	Belongs to the DEAD box helicase family
AOY20_RS12985	COG1278	Cold shock
AOY20_RS13000	COG2363	Small membrane protein
AOY20_RS13025	COG0659	secondary active sulfate transmembrane transporter activity
AOY20_RS13040	COG1305	Transglutaminase-like
AOY20_RS13050	COG2308	Evidence 4 Homologs of previously reported genes of
AOY20_RS13080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOY20_RS13085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOY20_RS13090	COG1845	cytochrome c oxidase, subunit III
AOY20_RS13095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOY20_RS13115	COG0360	Binds together with S18 to 16S ribosomal RNA
AOY20_RS13130	COG0305	Participates in initiation and elongation during chromosome replication
AOY20_RS13135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOY20_RS13140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOY20_RS13160	COG0540	Belongs to the ATCase OTCase family
AOY20_RS13170	COG2351	hydroxyisourate hydrolase activity
AOY20_RS13175	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AOY20_RS13190	COG0826	peptidase U32
AOY20_RS13195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOY20_RS13200	COG2084	Dehydrogenase
AOY20_RS13205	COG2233	PERMEase
AOY20_RS13210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOY20_RS13215	COG0251	oxidation-reduction process
AOY20_RS13220	COG1335	isochorismatase
AOY20_RS13225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOY20_RS13230	COG0596	Alpha beta hydrolase
AOY20_RS13255	COG4770	biotin carboxylase activity
AOY20_RS13260	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AOY20_RS13275	COG1914	H( )-stimulated, divalent metal cation uptake system
AOY20_RS13280	COG0583	DNA-binding transcription factor activity
AOY20_RS13295	COG1028	Short-chain dehydrogenase reductase Sdr
AOY20_RS13300	COG0583	DNA-binding transcription factor activity
AOY20_RS13305	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOY20_RS13310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOY20_RS13315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOY20_RS13325	COG0281	malic enzyme
AOY20_RS13325	COG0280	phosphate acetyltransferase
AOY20_RS13360	COG0556	nucleotide-excision repair
AOY20_RS13375	COG0436	Aminotransferase
AOY20_RS13390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOY20_RS13405	COG2814	Major facilitator Superfamily
AOY20_RS13415	COG0477	Major facilitator Superfamily
AOY20_RS13420	COG0583	DNA-binding transcription factor activity
AOY20_RS13425	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS13430	COG2301	Belongs to the HpcH HpaI aldolase family
AOY20_RS13435	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AOY20_RS13450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOY20_RS13455	COG0183	Belongs to the thiolase family
AOY20_RS13460	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOY20_RS13465	COG1024	Enoyl-CoA hydratase
AOY20_RS13470	COG1960	acyl-CoA dehydrogenase activity
AOY20_RS13475	COG2814	Major facilitator Superfamily
AOY20_RS13480	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOY20_RS13480	COG0644	oxidoreductase
AOY20_RS13490	COG0425	Belongs to the sulfur carrier protein TusA family
AOY20_RS13535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOY20_RS13545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOY20_RS13555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOY20_RS13560	COG0527	aspartate kinase activity
AOY20_RS13570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOY20_RS13580	COG3038	cytochrome b561
AOY20_RS13590	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOY20_RS13595	COG2252	PERMEase
AOY20_RS13615	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOY20_RS13620	COG1381	Involved in DNA repair and RecF pathway recombination
AOY20_RS13630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOY20_RS13635	COG0571	ribonuclease III activity
AOY20_RS13640	COG0681	Belongs to the peptidase S26 family
AOY20_RS13655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOY20_RS13670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOY20_RS13675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOY20_RS13680	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOY20_RS13695	COG4208	sulfate ABC transporter
AOY20_RS13700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOY20_RS13705	COG0583	DNA-binding transcription factor activity
AOY20_RS13725	COG0602	queuosine metabolic process
AOY20_RS13730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOY20_RS13740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOY20_RS13760	COG1056	cytidyltransferase-related domain
AOY20_RS13760	COG1051	belongs to the nudix hydrolase family
AOY20_RS13765	COG1024	Enoyl-CoA hydratase
AOY20_RS13790	COG3180	Ammonia monooxygenase
AOY20_RS13795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOY20_RS13795	COG3323	Protein of unknown function (DUF1653)
AOY20_RS13800	COG0583	DNA-binding transcription factor activity
AOY20_RS13820	COG0047	phosphoribosylformylglycinamidine synthase activity
AOY20_RS13820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOY20_RS13825	COG2234	aminopeptidase activity
AOY20_RS13840	COG2255	four-way junction helicase activity
AOY20_RS13850	COG1473	amidohydrolase
AOY20_RS13860	COG0824	Thioesterase
AOY20_RS13880	COG0823	Involved in the tonB-independent uptake of proteins
AOY20_RS13885	COG2885	chlorophyll binding
AOY20_RS13900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOY20_RS13920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOY20_RS13925	COG0628	permease
AOY20_RS13930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOY20_RS13935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOY20_RS13955	COG2333	competence protein COMEC
AOY20_RS13955	COG0658	competence protein
AOY20_RS13960	COG1136	(ABC) transporter
AOY20_RS13970	COG0697	spore germination
AOY20_RS13975	COG1671	Belongs to the UPF0178 family
AOY20_RS13995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOY20_RS14010	COG1301	dicarboxylic acid transport
AOY20_RS14025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOY20_RS14030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOY20_RS14045	COG0741	lytic transglycosylase activity
AOY20_RS14045	COG1196	nuclear chromosome segregation
AOY20_RS14045	COG0739	heme binding
AOY20_RS14050	COG0501	Belongs to the peptidase M48B family
AOY20_RS14060	COG2239	Acts as a magnesium transporter
AOY20_RS14065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOY20_RS14095	COG2852	Protein conserved in bacteria
AOY20_RS14100	COG2376	Dihydroxyacetone kinase
AOY20_RS14140	COG1280	lysine exporter protein (LysE YggA)
AOY20_RS14145	COG1522	sequence-specific DNA binding
AOY20_RS14155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOY20_RS14165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOY20_RS14170	COG0019	diaminopimelate decarboxylase activity
AOY20_RS14180	COG1113	amino acid transport
AOY20_RS14185	COG1115	amino acid carrier protein
AOY20_RS14190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOY20_RS14195	COG0583	DNA-binding transcription factor activity
AOY20_RS14225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOY20_RS14230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOY20_RS14235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOY20_RS14250	COG1773	rubredoxin
AOY20_RS14255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOY20_RS14260	COG1073	alpha beta
AOY20_RS14265	COG0583	DNA-binding transcription factor activity
AOY20_RS14275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOY20_RS14285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOY20_RS14290	COG4181	ATPase activity