locus-tag	class	description
AS4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AS4_RS00010	COG0592	DNA-directed DNA polymerase activity
AS4_RS00020	COG0187	DNA topoisomerase II activity
AS4_RS00030	COG0488	(ABC) transporter
AS4_RS00040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AS4_RS00045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AS4_RS00050	COG0596	Alpha beta hydrolase
AS4_RS00070	COG0657	acetylesterase activity
AS4_RS00075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AS4_RS00115	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS00120	COG3738	Protein conserved in bacteria
AS4_RS00125	COG0733	neurotransmitter:sodium symporter activity
AS4_RS00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AS4_RS00135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS4_RS00140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AS4_RS00160	COG0129	dihydroxy-acid dehydratase activity
AS4_RS00180	COG0174	glutamine synthetase
AS4_RS00190	COG0583	DNA-binding transcription factor activity
AS4_RS00195	COG1794	racemase activity, acting on amino acids and derivatives
AS4_RS00200	COG1047	Peptidyl-prolyl cis-trans
AS4_RS00205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AS4_RS00210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AS4_RS00215	COG0196	riboflavin kinase activity
AS4_RS00230	COG2233	PERMEase
AS4_RS00235	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AS4_RS00240	COG1309	transcriptional regulator
AS4_RS00285	COG2814	Major facilitator Superfamily
AS4_RS00290	COG0656	L-ascorbic acid biosynthetic process
AS4_RS00295	COG0583	DNA-binding transcription factor activity
AS4_RS00310	COG1064	alcohol dehydrogenase
AS4_RS00315	COG2818	Glycosylase
AS4_RS00330	COG1194	a g-specific adenine glycosylase
AS4_RS00345	COG5487	UPF0391 membrane protein
AS4_RS00350	COG2983	Belongs to the UPF0260 family
AS4_RS00360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AS4_RS00400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS4_RS00405	COG1335	isochorismatase
AS4_RS00410	COG0385	Bile acid
AS4_RS00415	COG1683	Conserved Protein
AS4_RS00425	COG0778	Nitroreductase
AS4_RS00430	COG1309	transcriptional regulator
AS4_RS00440	COG0640	Transcriptional regulator
AS4_RS00445	COG1230	cation diffusion facilitator family transporter
AS4_RS00450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AS4_RS00460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AS4_RS00465	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AS4_RS00470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AS4_RS00475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AS4_RS00490	COG0560	Phosphoserine phosphatase
AS4_RS00490	COG3830	Belongs to the UPF0237 family
AS4_RS00560	COG0534	Mate efflux family protein
AS4_RS00565	COG0436	Aminotransferase
AS4_RS00620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_RS00640	COG2733	membrane
AS4_RS00660	COG2918	glutathione biosynthetic process
AS4_RS00665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AS4_RS00680	COG3150	esterase
AS4_RS00755	COG3706	GGDEF domain
AS4_RS00760	COG3706	GGDEF domain
AS4_RS00775	COG1393	Belongs to the ArsC family
AS4_RS00780	COG0708	Exodeoxyribonuclease III
AS4_RS00795	COG2720	vancomycin resistance protein
AS4_RS00800	COG2226	methyltransferase
AS4_RS00810	COG0189	ligase activity
AS4_RS00820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS4_RS00830	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AS4_RS00845	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AS4_RS00870	COG2119	membrane
AS4_RS00875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS00875	COG0426	domain, Protein
AS4_RS00900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AS4_RS00950	COG2267	carboxylic ester hydrolase activity
AS4_RS00955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_RS00975	COG0351	phosphomethylpyrimidine kinase
AS4_RS00975	COG0352	thiamine-phosphate diphosphorylase activity
AS4_RS00975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS4_RS00985	COG2814	Major facilitator Superfamily
AS4_RS00990	COG0629	single-stranded DNA binding
AS4_RS01015	COG0583	DNA-binding transcription factor activity
AS4_RS01020	COG1335	isochorismatase
AS4_RS01030	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AS4_RS01055	COG3177	Filamentation induced by cAMP protein fic
AS4_RS01110	COG3158	transport of potassium into the cell
AS4_RS01125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS4_RS01145	COG0165	Argininosuccinate lyase
AS4_RS01150	COG3275	phosphorelay sensor kinase activity
AS4_RS01160	COG0181	hydroxymethylbilane synthase activity
AS4_RS01250	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AS4_RS01265	COG0081	regulation of translation
AS4_RS01275	COG0222	ribosome binding
AS4_RS01280	COG0085	RNA polymerase activity
AS4_RS01285	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AS4_RS01310	COG2056	Na+-H+ antiporter family
AS4_RS01325	COG0326	Molecular chaperone. Has ATPase activity
AS4_RS01340	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AS4_RS01370	COG0183	Belongs to the thiolase family
AS4_RS01375	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_RS01375	COG1024	Enoyl-CoA hydratase
AS4_RS01415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS4_RS01445	COG0795	lipopolysaccharide-transporting ATPase activity
AS4_RS01450	COG0795	lipopolysaccharide-transporting ATPase activity
AS4_RS01455	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AS4_RS01460	COG0793	Belongs to the peptidase S41A family
AS4_RS01475	COG2197	response regulator
AS4_RS01480	COG1686	Belongs to the peptidase S11 family
AS4_RS01495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AS4_RS01510	COG4974	Belongs to the 'phage' integrase family
AS4_RS01530	COG1132	(ABC) transporter
AS4_RS01540	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_RS01550	COG1289	transmembrane transporter activity
AS4_RS01570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AS4_RS01580	COG0497	DNA recombination
AS4_RS01585	COG3123	guanosine phosphorylase activity
AS4_RS01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS4_RS01600	COG0237	dephospho-CoA kinase activity
AS4_RS01605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AS4_RS01650	COG0779	Required for maturation of 30S ribosomal subunits
AS4_RS01655	COG0195	Participates in both transcription termination and antitermination
AS4_RS01660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AS4_RS01665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AS4_RS01675	COG1704	LemA family
AS4_RS01680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AS4_RS01700	COG3307	-O-antigen
AS4_RS01720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_RS01725	COG1758	RNA polymerase activity
AS4_RS01730	COG0194	GDP metabolic process
AS4_RS01740	COG4968	Prepilin-type N-terminal cleavage methylation domain
AS4_RS01750	COG4966	pilus assembly protein PilW
AS4_RS01770	COG4969	Belongs to the N-Me-Phe pilin family
AS4_RS01775	COG0228	four-way junction DNA binding
AS4_RS01780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AS4_RS01790	COG0335	large ribosomal subunit rRNA binding
AS4_RS01805	COG5380	lipid catabolic process
AS4_RS01810	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AS4_RS01835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_RS01845	COG5006	permease, DMT superfamily
AS4_RS01850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AS4_RS01855	COG0277	FAD linked oxidase domain protein
AS4_RS01870	COG1181	Belongs to the D-alanine--D-alanine ligase family
AS4_RS01895	COG2814	Major facilitator Superfamily
AS4_RS01905	COG1289	transmembrane transporter activity
AS4_RS01915	COG2032	superoxide dismutase activity
AS4_RS01920	COG0628	permease
AS4_RS01980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS4_RS02015	COG0751	glycine-tRNA ligase activity
AS4_RS02020	COG0752	glycyl-tRNA synthetase alpha subunit
AS4_RS02040	COG0277	FAD linked oxidase domain protein
AS4_RS02055	COG0517	IMP dehydrogenase activity
AS4_RS02060	COG1983	PspC domain protein
AS4_RS02100	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_RS02105	COG1530	ribonuclease E activity
AS4_RS02115	COG0564	pseudouridine synthase activity
AS4_RS02120	COG0546	phosphoglycolate phosphatase activity
AS4_RS02125	COG2378	regulation of single-species biofilm formation
AS4_RS02140	COG0583	DNA-binding transcription factor activity
AS4_RS02180	COG0753	catalase activity
AS4_RS02220	COG1960	acyl-CoA dehydrogenase activity
AS4_RS02245	COG0494	nUDIX hydrolase
AS4_RS02260	COG0583	DNA-binding transcription factor activity
AS4_RS02275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AS4_RS02290	COG0473	3-isopropylmalate dehydrogenase activity
AS4_RS02300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AS4_RS02320	COG0252	asparaginase activity
AS4_RS02355	COG1560	Kdo2-lipid A biosynthetic process
AS4_RS02375	COG0488	(ABC) transporter
AS4_RS02380	COG2900	Belongs to the SlyX family
AS4_RS02385	COG0583	DNA-binding transcription factor activity
AS4_RS02390	COG1914	H( )-stimulated, divalent metal cation uptake system
AS4_RS02405	COG1984	allophanate hydrolase subunit 2
AS4_RS02410	COG4770	biotin carboxylase activity
AS4_RS02420	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS02425	COG1733	regulation of RNA biosynthetic process
AS4_RS02460	COG1929	Belongs to the glycerate kinase type-1 family
AS4_RS02470	COG0210	DNA helicase
AS4_RS02490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS4_RS02490	COG4651	solute:proton antiporter activity
AS4_RS02515	COG0788	formyltetrahydrofolate deformylase activity
AS4_RS02555	COG1607	acyl-coa hydrolase
AS4_RS02570	COG1666	GTP binding
AS4_RS02575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AS4_RS02590	COG2350	Protein conserved in bacteria
AS4_RS02600	COG0613	PHP domain protein
AS4_RS02610	COG1702	phosphate starvation-inducible protein PhoH
AS4_RS02615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AS4_RS02620	COG0741	lytic transglycosylase activity
AS4_RS02620	COG1196	nuclear chromosome segregation
AS4_RS02620	COG0739	heme binding
AS4_RS02630	COG0039	L-malate dehydrogenase activity
AS4_RS02650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AS4_RS02655	COG1183	phosphatidylcholine synthase activity
AS4_RS02720	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AS4_RS02725	COG3878	Protein conserved in bacteria
AS4_RS02765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_RS02780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AS4_RS02800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_RS02800	COG2813	Specifically methylates the guanine in position
AS4_RS02810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AS4_RS02825	COG4774	siderophore transport
AS4_RS02835	COG0740	serine-type endopeptidase activity
AS4_RS02875	COG0280	phosphate acetyltransferase
AS4_RS02875	COG0857	belongs to the CobB CobQ family
AS4_RS02880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AS4_RS02905	COG0793	Belongs to the peptidase S41A family
AS4_RS02915	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AS4_RS02930	COG0084	hydrolase, TatD family'
AS4_RS02940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AS4_RS02955	COG0583	DNA-binding transcription factor activity
AS4_RS02960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS4_RS02975	COG0583	DNA-binding transcription factor activity
AS4_RS02990	COG1609	Transcriptional regulator
AS4_RS02995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_RS03005	COG0154	amidase activity
AS4_RS03025	COG0668	transmembrane transport
AS4_RS03045	COG2814	Major facilitator Superfamily
AS4_RS03100	COG1862	Preprotein translocase
AS4_RS03120	COG3201	nicotinamide mononucleotide transporter
AS4_RS03140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AS4_RS03350	COG4695	Portal protein
AS4_RS03365	COG2205	protein histidine kinase activity
AS4_RS03370	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AS4_RS03395	COG0438	transferase activity, transferring glycosyl groups
AS4_RS03415	COG3306	glycosyltransferase involved in LPS biosynthesis
AS4_RS03420	COG3306	glycosyltransferase involved in LPS biosynthesis
AS4_RS03425	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS4_RS03425	COG2755	lipolytic protein G-D-S-L family
AS4_RS03455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AS4_RS03510	COG1960	acyl-CoA dehydrogenase activity
AS4_RS03515	COG1960	acyl-CoA dehydrogenase activity
AS4_RS03525	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_RS03540	COG0277	FAD linked oxidase domain protein
AS4_RS03565	COG0625	glutathione transferase activity
AS4_RS03580	COG1238	metal cluster binding
AS4_RS03595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AS4_RS03635	COG0072	phenylalanine-tRNA ligase activity
AS4_RS03640	COG0776	regulation of translation
AS4_RS03660	COG0248	Ppx GppA phosphatase
AS4_RS03670	COG0037	tRNA processing
AS4_RS03695	COG0183	Belongs to the thiolase family
AS4_RS03720	COG1690	Belongs to the RtcB family
AS4_RS03725	COG0833	amino acid
AS4_RS03735	COG2233	PERMEase
AS4_RS03740	COG1217	gtp-binding protein TYPA
AS4_RS03745	COG1970	mechanosensitive ion channel activity
AS4_RS03755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS4_RS03765	COG3659	wide pore channel activity
AS4_RS03770	COG4772	TonB-dependent receptor
AS4_RS03775	COG1902	pentaerythritol trinitrate reductase activity
AS4_RS03825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AS4_RS03860	COG5002	protein histidine kinase activity
AS4_RS03860	COG5001	Diguanylate cyclase
AS4_RS03860	COG3447	MASE1 domain protein
AS4_RS03880	COG2969	positive regulation of protein catabolic process
AS4_RS03885	COG0625	glutathione transferase activity
AS4_RS03895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AS4_RS03900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AS4_RS03910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AS4_RS03915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AS4_RS03920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_RS03945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AS4_RS03955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS4_RS03960	COG1408	metallophosphoesterase
AS4_RS03990	COG2824	Alkylphosphonate utilization operon protein PhnA
AS4_RS03995	COG2197	response regulator
AS4_RS04000	COG0477	Major facilitator Superfamily
AS4_RS04025	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AS4_RS04035	COG4166	transmembrane transport
AS4_RS04040	COG4166	transmembrane transport
AS4_RS04055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS4_RS04075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AS4_RS04080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AS4_RS04110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AS4_RS04115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS04135	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AS4_RS04210	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS4_RS04220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AS4_RS04220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AS4_RS04225	COG0745	RESPONSE REGULATOR receiver
AS4_RS04230	COG2205	protein histidine kinase activity
AS4_RS04250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_RS04270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AS4_RS04280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AS4_RS04285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_RS04295	COG0713	ATP synthesis coupled electron transport
AS4_RS04300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS4_RS04305	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AS4_RS04315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AS4_RS04330	COG0583	DNA-binding transcription factor activity
AS4_RS04350	COG2050	protein possibly involved in aromatic compounds catabolism
AS4_RS04355	COG1566	PFAM secretion protein HlyD family protein
AS4_RS04360	COG2814	Major facilitator Superfamily
AS4_RS04370	COG3177	Filamentation induced by cAMP protein fic
AS4_RS04380	COG5295	Hep Hag repeat protein
AS4_RS04380	COG5295	Hep Hag repeat protein
AS4_RS04385	COG0306	phosphate transporter
AS4_RS04400	COG0175	sulfate reduction
AS4_RS04420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS4_RS04420	COG0604	alcohol dehydrogenase
AS4_RS04420	COG3321	synthase
AS4_RS04420	COG4221	oxidoreductase activity
AS4_RS04440	COG2851	Citrate transporter
AS4_RS04445	COG1253	flavin adenine dinucleotide binding
AS4_RS04465	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AS4_RS04470	COG2894	cell division
AS4_RS04475	COG0850	regulation of cytokinetic process
AS4_RS04485	COG0204	Acyl-transferase
AS4_RS04490	COG2885	chlorophyll binding
AS4_RS04500	COG0756	dUTP diphosphatase activity
AS4_RS04505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS4_RS04510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS4_RS04520	COG0121	glutamine amidotransferase
AS4_RS04535	COG2914	Belongs to the UPF0125 (RnfH) family
AS4_RS04540	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_RS04545	COG0735	belongs to the Fur family
AS4_RS04565	COG1968	undecaprenyl-diphosphatase activity
AS4_RS04595	COG0420	3'-5' exonuclease activity
AS4_RS04630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS4_RS04645	COG0786	glutamate:sodium symporter activity
AS4_RS04650	COG2059	Chromate
AS4_RS04655	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS4_RS04660	COG1607	acyl-coa hydrolase
AS4_RS04690	COG0523	cobalamin synthesis protein
AS4_RS04695	COG4681	YaeQ
AS4_RS04715	COG1649	PFAM Uncharacterised BCR, COG1649
AS4_RS04715	COG0726	polysaccharide deacetylase
AS4_RS04720	COG1215	transferase activity, transferring glycosyl groups
AS4_RS04755	COG1309	transcriptional regulator
AS4_RS04765	COG1024	Enoyl-CoA hydratase
AS4_RS04780	COG4771	TonB-dependent receptor
AS4_RS04815	COG1113	amino acid transport
AS4_RS04820	COG2828	Protein conserved in bacteria
AS4_RS04825	COG2203	Gaf domain
AS4_RS04825	COG2199	diguanylate cyclase activity
AS4_RS04830	COG0142	geranyltranstransferase activity
AS4_RS04850	COG1752	Esterase of the alpha-beta hydrolase superfamily
AS4_RS04860	COG2814	Major facilitator Superfamily
AS4_RS04865	COG2194	sulfuric ester hydrolase activity
AS4_RS04875	COG0642	Histidine kinase
AS4_RS04890	COG0004	ammonium transporteR
AS4_RS04935	COG0525	valine-tRNA ligase activity
AS4_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS04965	COG0393	Putative heavy-metal-binding
AS4_RS04970	COG1538	Outer membrane efflux protein
AS4_RS04980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS04985	COG0671	phosphoesterase, PA-phosphatase related
AS4_RS05000	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AS4_RS05010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AS4_RS05015	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
AS4_RS05020	COG2072	flavoprotein involved in K transport
AS4_RS05040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AS4_RS05045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AS4_RS05045	COG1648	precorrin-2 dehydrogenase activity
AS4_RS05050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AS4_RS05080	COG0531	amino acid
AS4_RS05095	COG0321	lipoyl(octanoyl) transferase activity
AS4_RS05100	COG2921	Belongs to the UPF0250 family
AS4_RS05120	COG1280	lysine exporter protein (LysE YggA)
AS4_RS05125	COG0586	Pfam SNARE associated Golgi protein
AS4_RS05140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS4_RS05165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AS4_RS05170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AS4_RS05230	COG0564	pseudouridine synthase activity
AS4_RS05270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AS4_RS05275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AS4_RS05280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS4_RS05340	COG0477	Major facilitator Superfamily
AS4_RS05365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AS4_RS05370	COG1597	lipid kinase activity
AS4_RS05385	COG0459	protein refolding
AS4_RS05400	COG0584	glycerophosphoryl diester phosphodiesterase
AS4_RS05405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_RS05410	COG2239	Acts as a magnesium transporter
AS4_RS05440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS4_RS05445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS4_RS05450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS4_RS05470	COG1113	amino acid transport
AS4_RS05480	COG0019	diaminopimelate decarboxylase activity
AS4_RS05505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AS4_RS05515	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
AS4_RS05535	COG0833	amino acid
AS4_RS05545	COG0833	amino acid
AS4_RS05555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS4_RS05560	COG0418	dihydroorotase activity
AS4_RS05580	COG0501	Belongs to the peptidase M48B family
AS4_RS05585	COG0741	lytic transglycosylase activity
AS4_RS05590	COG0037	tRNA processing
AS4_RS05600	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AS4_RS05605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS4_RS05625	COG3220	belongs to the UPF0276 family
AS4_RS05635	COG1595	DNA-templated transcription, initiation
AS4_RS05660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AS4_RS05675	COG0642	Histidine kinase
AS4_RS05695	COG4771	TonB-dependent receptor
AS4_RS05705	COG1595	DNA-templated transcription, initiation
AS4_RS05720	COG0477	Major facilitator Superfamily
AS4_RS05740	COG1309	transcriptional regulator
AS4_RS05790	COG3188	usher protein
AS4_RS05815	COG1598	PFAM Uncharacterised protein family UPF0150
AS4_RS05820	COG3539	Fimbrial protein
AS4_RS05865	COG2207	Transcriptional regulator
AS4_RS05885	COG3121	Chaperone
AS4_RS05895	COG3539	Fimbrial protein
AS4_RS05920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_RS05920	COG1116	anion transmembrane transporter activity
AS4_RS05930	COG2223	nitrite transmembrane transporter activity
AS4_RS05935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_RS05940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_RS05945	COG0243	molybdopterin cofactor binding
AS4_RS05960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS4_RS05970	COG0314	molybdopterin synthase activity
AS4_RS05975	COG1414	Transcriptional regulator
AS4_RS05980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_RS05985	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_RS05990	COG0183	Belongs to the thiolase family
AS4_RS05995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AS4_RS06000	COG0596	Alpha beta hydrolase
AS4_RS06005	COG2271	Major facilitator Superfamily
AS4_RS06010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_RS06015	COG3485	protocatechuate 3,4-dioxygenase
AS4_RS06020	COG3485	protocatechuate 3,4-dioxygenase
AS4_RS06025	COG0710	3-dehydroquinate dehydratase activity
AS4_RS06030	COG3420	alginic acid biosynthetic process
AS4_RS06035	COG3659	wide pore channel activity
AS4_RS06040	COG4993	Dehydrogenase
AS4_RS06045	COG0789	Transcriptional regulator
AS4_RS06050	COG2217	Heavy metal translocating P-type atpase
AS4_RS06065	COG2205	protein histidine kinase activity
AS4_RS06080	COG1923	regulation of RNA biosynthetic process
AS4_RS06090	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AS4_RS06095	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AS4_RS06105	COG2205	protein histidine kinase activity
AS4_RS06110	COG0745	RESPONSE REGULATOR receiver
AS4_RS06120	COG1073	alpha beta
AS4_RS06125	COG0583	DNA-binding transcription factor activity
AS4_RS06150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS4_RS06185	COG0006	proline dipeptidase activity
AS4_RS06195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_RS06200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_RS06245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AS4_RS06250	COG1388	LysM domain
AS4_RS06250	COG0741	lytic transglycosylase activity
AS4_RS06255	COG4166	transmembrane transport
AS4_RS06260	COG4174	ABC transporter (Permease)
AS4_RS06265	COG4239	(ABC) transporter, permease
AS4_RS06270	COG4172	Belongs to the ABC transporter superfamily
AS4_RS06300	COG0052	Belongs to the universal ribosomal protein uS2 family
AS4_RS06305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AS4_RS06355	COG2951	lytic endotransglycosylase activity
AS4_RS06360	COG0772	Belongs to the SEDS family
AS4_RS06375	COG0842	Transport permease protein
AS4_RS06380	COG1131	(ABC) transporter
AS4_RS06390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS4_RS06395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AS4_RS06450	COG1476	TRANSCRIPTIONal
AS4_RS06570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AS4_RS06585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AS4_RS06600	COG2233	PERMEase
AS4_RS06610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS06615	COG1823	symporter activity
AS4_RS06630	COG0612	Peptidase, M16
AS4_RS06645	COG1720	tRNA m6t6A37 methyltransferase activity
AS4_RS06665	COG0352	thiamine-phosphate diphosphorylase activity
AS4_RS06710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AS4_RS06715	COG3111	PFAM Bacterial OB fold (BOF) protein
AS4_RS06725	COG0642	Histidine kinase
AS4_RS06735	COG0494	nUDIX hydrolase
AS4_RS06745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AS4_RS06750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AS4_RS06755	COG3139	Protein of unknown function (DUF1315)
AS4_RS06765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS4_RS06770	COG1301	dicarboxylic acid transport
AS4_RS06780	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AS4_RS06790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AS4_RS06820	COG2318	DinB family
AS4_RS06825	COG2070	2-Nitropropane dioxygenase
AS4_RS06880	COG1643	Atp-dependent helicase
AS4_RS06915	COG2831	hemolysin activation secretion protein
AS4_RS06920	COG2188	Transcriptional regulator
AS4_RS06940	COG1113	amino acid transport
AS4_RS06955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS4_RS06970	COG3706	GGDEF domain
AS4_RS06980	COG2072	flavoprotein involved in K transport
AS4_RS06985	COG0300	oxidoreductase activity
AS4_RS06990	COG1280	lysine exporter protein (LysE YggA)
AS4_RS07005	COG1136	(ABC) transporter
AS4_RS07010	COG2333	competence protein COMEC
AS4_RS07010	COG0658	competence protein
AS4_RS07030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AS4_RS07040	COG0628	permease
AS4_RS07080	COG3634	alkyl hydroperoxide reductase activity
AS4_RS07085	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AS4_RS07090	COG0583	DNA-binding transcription factor activity
AS4_RS07095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AS4_RS07100	COG0826	peptidase U32
AS4_RS07110	COG0640	Transcriptional regulator
AS4_RS07115	COG0798	PFAM Bile acid sodium symporter
AS4_RS07120	COG0789	Transcriptional regulator
AS4_RS07160	COG1022	Amp-dependent synthetase and ligase
AS4_RS07210	COG4772	TonB-dependent receptor
AS4_RS07220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AS4_RS07225	COG0076	glutamate decarboxylase activity
AS4_RS07235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AS4_RS07275	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS07280	COG3268	Saccharopine dehydrogenase
AS4_RS07295	COG0753	catalase activity
AS4_RS07300	COG0113	porphobilinogen synthase activity
AS4_RS07325	COG0789	Transcriptional regulator
AS4_RS07335	COG3231	kanamycin kinase activity
AS4_RS07350	COG1960	acyl-CoA dehydrogenase activity
AS4_RS07355	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS07360	COG3829	transcription factor binding
AS4_RS07385	COG1846	Transcriptional regulator
AS4_RS07405	COG3539	Fimbrial protein
AS4_RS07420	COG3539	Fimbrial protein
AS4_RS07430	COG2197	response regulator
AS4_RS07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_RS07435	COG2198	Histidine kinase
AS4_RS07435	COG2205	protein histidine kinase activity
AS4_RS07435	COG0784	Response regulator, receiver
AS4_RS07450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_RS07455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AS4_RS07460	COG0315	cyclic pyranopterin monophosphate synthase activity
AS4_RS07460	COG0521	Mo-molybdopterin cofactor biosynthetic process
AS4_RS07465	COG0303	'Molybdopterin
AS4_RS07485	COG0243	molybdopterin cofactor binding
AS4_RS07490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AS4_RS07495	COG0725	ABC transporter, periplasmic molybdate-binding protein
AS4_RS07500	COG4149	molybdate abc transporter
AS4_RS07510	COG0443	Heat shock 70 kDa protein
AS4_RS07520	COG2831	hemolysin activation secretion protein
AS4_RS07525	COG2994	toxin metabolic process
AS4_RS07575	COG2801	Transposase and inactivated derivatives
AS4_RS07580	COG1522	sequence-specific DNA binding
AS4_RS07595	COG1234	tRNA 3'-trailer cleavage
AS4_RS07630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS07645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_RS07645	COG0543	2 iron, 2 sulfur cluster binding
AS4_RS07650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AS4_RS07655	COG4638	Rieske (2fe-2S)
AS4_RS07665	COG2814	Major facilitator Superfamily
AS4_RS07680	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_RS07690	COG0154	amidase activity
AS4_RS07705	COG4638	Rieske (2fe-2S)
AS4_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS07725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS07735	COG3733	amine oxidase
AS4_RS07745	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS07755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_RS07760	COG0183	Belongs to the thiolase family
AS4_RS07765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_RS07770	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_RS07775	COG4829	muconolactone delta-isomerase
AS4_RS07780	COG4948	Mandelate Racemase Muconate Lactonizing
AS4_RS07785	COG0583	DNA-binding transcription factor activity
AS4_RS07790	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AS4_RS07795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS4_RS07800	COG3485	protocatechuate 3,4-dioxygenase
AS4_RS07815	COG1294	oxidase, subunit
AS4_RS07820	COG1271	oxidase subunit
AS4_RS07825	COG1380	Effector of murein hydrolase LrgA
AS4_RS07830	COG1346	cytolysis
AS4_RS07880	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_RS07890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS4_RS07910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AS4_RS07910	COG0644	oxidoreductase
AS4_RS07915	COG2814	Major facilitator Superfamily
AS4_RS07920	COG1960	acyl-CoA dehydrogenase activity
AS4_RS07925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS4_RS07945	COG2814	Major facilitator Superfamily
AS4_RS07955	COG0183	Belongs to the thiolase family
AS4_RS07960	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_RS07970	COG1024	Enoyl-CoA hydratase
AS4_RS07975	COG1960	acyl-CoA dehydrogenase activity
AS4_RS07980	COG2814	Major facilitator Superfamily
AS4_RS07985	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AS4_RS07990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_RS08000	COG2814	Major facilitator Superfamily
AS4_RS08010	COG1960	acyl-CoA dehydrogenase activity
AS4_RS08015	COG1024	Enoyl-CoA hydratase
AS4_RS08025	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS08035	COG2610	gluconate transmembrane transporter activity
AS4_RS08040	COG0583	DNA-binding transcription factor activity
AS4_RS08050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AS4_RS08065	COG3836	Belongs to the HpcH HpaI aldolase family
AS4_RS08070	COG4264	IucA IucC family
AS4_RS08080	COG4264	IucA IucC family
AS4_RS08085	COG2423	ornithine cyclodeaminase activity
AS4_RS08090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS4_RS08155	COG0583	DNA-binding transcription factor activity
AS4_RS08160	COG0473	3-isopropylmalate dehydrogenase activity
AS4_RS08170	COG0657	acetylesterase activity
AS4_RS08175	COG4638	Rieske (2fe-2S)
AS4_RS08180	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS08200	COG2871	sodium ion transport
AS4_RS08235	COG5002	protein histidine kinase activity
AS4_RS08240	COG0745	RESPONSE REGULATOR receiver
AS4_RS08245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS08265	COG2832	Protein of unknown function (DUF454)
AS4_RS08275	COG1595	DNA-templated transcription, initiation
AS4_RS08315	COG0436	Aminotransferase
AS4_RS08330	COG2199	diguanylate cyclase activity
AS4_RS08340	COG0556	nucleotide-excision repair
AS4_RS08350	COG2962	Rard protein
AS4_RS08380	COG0702	epimerase
AS4_RS08385	COG1733	regulation of RNA biosynthetic process
AS4_RS08400	COG2915	High frequency lysogenization protein hflD homolog
AS4_RS08420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS4_RS08425	COG1686	Belongs to the peptidase S11 family
AS4_RS08455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AS4_RS08460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AS4_RS08465	COG1067	ATP-dependent peptidase activity
AS4_RS08500	COG1509	lysine 2,3-aminomutase activity
AS4_RS08505	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AS4_RS08510	COG1966	Carbon starvation protein
AS4_RS08515	COG2879	small protein
AS4_RS08525	COG0714	Associated with various cellular activities
AS4_RS08770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_RS08810	COG5487	UPF0391 membrane protein
AS4_RS08880	COG4771	TonB-dependent receptor
AS4_RS08895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS08900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_RS08920	COG2252	PERMEase
AS4_RS08925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AS4_RS08935	COG3038	cytochrome b561
AS4_RS08945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AS4_RS08955	COG0527	aspartate kinase activity
AS4_RS08975	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AS4_RS09000	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
AS4_RS09005	COG1522	sequence-specific DNA binding
AS4_RS09010	COG1335	isochorismatase
AS4_RS09025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AS4_RS09045	COG0667	Aldo Keto reductase
AS4_RS09055	COG1765	OsmC-like protein
AS4_RS09065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AS4_RS09070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS4_RS09080	COG1045	serine acetyltransferase
AS4_RS09090	COG0542	response to heat
AS4_RS09120	COG0540	Belongs to the ATCase OTCase family
AS4_RS09145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_RS09155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AS4_RS09160	COG0583	DNA-binding transcription factor activity
AS4_RS09195	COG0693	protein deglycase activity
AS4_RS09215	COG1802	Transcriptional regulator
AS4_RS09250	COG0204	Acyl-transferase
AS4_RS09265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AS4_RS09275	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AS4_RS09285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AS4_RS09305	COG0477	Major facilitator Superfamily
AS4_RS09310	COG0729	surface antigen
AS4_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_RS09335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AS4_RS09340	COG4783	chaperone-mediated protein folding
AS4_RS09355	COG1610	YqeY-like protein
AS4_RS09385	COG0436	Aminotransferase
AS4_RS09390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AS4_RS09395	COG0386	Belongs to the glutathione peroxidase family
AS4_RS09400	COG2207	Transcriptional regulator
AS4_RS09400	COG1917	Cupin 2, conserved barrel domain protein
AS4_RS09415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS09430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AS4_RS09450	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AS4_RS09475	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AS4_RS09480	COG0012	GTP binding
AS4_RS09485	COG2011	ABC-type metal ion transport system permease component
AS4_RS09490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS4_RS09495	COG1464	Belongs to the NlpA lipoprotein family
AS4_RS09500	COG1464	Belongs to the NlpA lipoprotein family
AS4_RS09570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AS4_RS09580	COG0786	glutamate:sodium symporter activity
AS4_RS09595	COG2707	UPF0756 membrane protein
AS4_RS09600	COG1959	2 iron, 2 sulfur cluster binding
AS4_RS09635	COG0802	atpase or kinase
AS4_RS09640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AS4_RS09650	COG1923	regulation of RNA biosynthetic process
AS4_RS09655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AS4_RS09665	COG3178	'Phosphotransferase
AS4_RS09670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AS4_RS09680	COG1192	Involved in chromosome partitioning
AS4_RS09685	COG1475	DNA binding
AS4_RS09690	COG0811	peptide transport
AS4_RS09700	COG1132	(ABC) transporter
AS4_RS09705	COG1663	tetraacyldisaccharide 4'-kinase activity
AS4_RS09725	COG0084	hydrolase, TatD family'
AS4_RS09750	COG3156	type II secretion system protein K
AS4_RS09760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AS4_RS09770	COG0590	tRNA wobble adenosine to inosine editing
AS4_RS09810	COG3121	Chaperone
AS4_RS09815	COG3539	Fimbrial protein
AS4_RS09835	COG0284	orotidine-5'-phosphate decarboxylase activity
AS4_RS09840	COG2431	L-lysine efflux transmembrane transporter activity
AS4_RS09855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AS4_RS09860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AS4_RS09865	COG0569	domain protein
AS4_RS09880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AS4_RS09885	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AS4_RS09910	COG3706	GGDEF domain
AS4_RS09925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AS4_RS09930	COG0542	response to heat
AS4_RS09960	COG0583	DNA-binding transcription factor activity
AS4_RS09965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_RS09975	COG0583	DNA-binding transcription factor activity
AS4_RS09980	COG1960	acyl-CoA dehydrogenase activity
AS4_RS09985	COG2814	Major facilitator Superfamily
AS4_RS10020	COG0372	Belongs to the citrate synthase family
AS4_RS10035	COG0069	glutamate synthase activity
AS4_RS10050	COG2850	peptidyl-arginine hydroxylation
AS4_RS10065	COG0424	maF-like protein
AS4_RS10075	COG0126	phosphoglycerate kinase activity
AS4_RS10105	COG3196	Protein conserved in bacteria
AS4_RS10135	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AS4_RS10145	COG0702	epimerase
AS4_RS10150	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS4_RS10185	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AS4_RS10215	COG0316	Belongs to the HesB IscA family
AS4_RS10220	COG0822	iron-sulfur transferase activity
AS4_RS10230	COG1959	2 iron, 2 sulfur cluster binding
AS4_RS10245	COG0776	regulation of translation
AS4_RS10255	COG2207	Transcriptional regulator
AS4_RS10260	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_RS10290	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AS4_RS10330	COG1335	isochorismatase
AS4_RS10365	COG1271	oxidase subunit
AS4_RS10370	COG1294	oxidase, subunit
AS4_RS10380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS4_RS10400	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AS4_RS10435	COG0583	DNA-binding transcription factor activity
AS4_RS10495	COG2814	Major facilitator Superfamily
AS4_RS10505	COG0583	DNA-binding transcription factor activity
AS4_RS10510	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS10525	COG0697	spore germination
AS4_RS10530	COG0436	Aminotransferase
AS4_RS10540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AS4_RS10560	COG0488	(ABC) transporter
AS4_RS10570	COG0596	Alpha beta hydrolase
AS4_RS10575	COG3135	benzoate transporter
AS4_RS10600	COG2814	Major facilitator Superfamily
AS4_RS10605	COG1346	cytolysis
AS4_RS10610	COG1380	Effector of murein hydrolase LrgA
AS4_RS10615	COG0583	DNA-binding transcription factor activity
AS4_RS10620	COG4628	conserved protein (DUF2132)
AS4_RS10630	COG1309	transcriptional regulator
AS4_RS10655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_RS10675	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS10680	COG0583	DNA-binding transcription factor activity
AS4_RS10690	COG0626	cystathionine gamma-synthase activity
AS4_RS10695	COG1024	Enoyl-CoA hydratase
AS4_RS10700	COG1960	acyl-CoA dehydrogenase activity
AS4_RS10755	COG1773	rubredoxin
AS4_RS10765	COG2197	response regulator
AS4_RS10770	COG1522	sequence-specific DNA binding
AS4_RS10775	COG0583	DNA-binding transcription factor activity
AS4_RS10780	COG2814	Major facilitator Superfamily
AS4_RS10795	COG3119	arylsulfatase activity
AS4_RS10800	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AS4_RS10810	COG4774	siderophore transport
AS4_RS10820	COG1846	Transcriptional regulator
AS4_RS10825	COG1309	transcriptional regulator
AS4_RS10850	COG1024	Enoyl-CoA hydratase
AS4_RS10855	COG1960	acyl-CoA dehydrogenase activity
AS4_RS10860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_RS10875	COG0583	DNA-binding transcription factor activity
AS4_RS10895	COG1944	ATP diphosphatase activity
AS4_RS10910	COG2304	oxidoreductase activity
AS4_RS10950	COG1358	cellular component organization or biogenesis
AS4_RS10985	COG4245	von Willebrand factor, type A
AS4_RS11005	COG2072	flavoprotein involved in K transport
AS4_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS11040	COG0583	DNA-binding transcription factor activity
AS4_RS11045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_RS11050	COG4266	Belongs to the allantoicase family
AS4_RS11055	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AS4_RS11065	COG2351	hydroxyisourate hydrolase activity
AS4_RS11095	COG0804	urea catabolic process
AS4_RS11125	COG0830	nickel cation binding
AS4_RS11135	COG0589	response to stress
AS4_RS11185	COG1960	acyl-CoA dehydrogenase activity
AS4_RS11190	COG1960	acyl-CoA dehydrogenase activity
AS4_RS11210	COG0509	glycine decarboxylation via glycine cleavage system
AS4_RS11300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS4_RS11335	COG0640	Transcriptional regulator
AS4_RS11355	COG3122	Protein conserved in bacteria
AS4_RS11370	COG0588	phosphoglycerate mutase activity
AS4_RS11375	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AS4_RS11390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS4_RS11410	COG2223	nitrite transmembrane transporter activity
AS4_RS11445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AS4_RS11465	COG1733	regulation of RNA biosynthetic process
AS4_RS11475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AS4_RS11480	COG2267	carboxylic ester hydrolase activity
AS4_RS11485	COG0671	phosphoesterase, PA-phosphatase related
AS4_RS11485	COG2453	phosphatase
AS4_RS11500	COG4589	Belongs to the CDS family
AS4_RS11515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AS4_RS11520	COG2937	Belongs to the GPAT DAPAT family
AS4_RS11525	COG2226	methyltransferase
AS4_RS11525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AS4_RS11525	COG0596	Alpha beta hydrolase
AS4_RS11530	COG1309	transcriptional regulator
AS4_RS11560	COG0667	Aldo Keto reductase
AS4_RS11585	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_RS11610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AS4_RS11615	COG0772	Belongs to the SEDS family
AS4_RS11625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AS4_RS11635	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AS4_RS11650	COG1027	Aspartate ammonia-lyase
AS4_RS11670	COG1902	pentaerythritol trinitrate reductase activity
AS4_RS11670	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_RS11680	COG2267	carboxylic ester hydrolase activity
AS4_RS11690	COG2814	Major facilitator Superfamily
AS4_RS11695	COG0583	DNA-binding transcription factor activity
AS4_RS11705	COG4638	Rieske (2fe-2S)
AS4_RS11710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AS4_RS11715	COG0633	Ferredoxin
AS4_RS11715	COG0543	2 iron, 2 sulfur cluster binding
AS4_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS11725	COG3135	benzoate transporter
AS4_RS11750	COG0477	Major facilitator Superfamily
AS4_RS11775	COG1027	Aspartate ammonia-lyase
AS4_RS11790	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AS4_RS11790	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AS4_RS11790	COG0506	proline dehydrogenase activity
AS4_RS11840	COG1570	exodeoxyribonuclease VII activity
AS4_RS11850	COG0308	aminopeptidase N
AS4_RS11870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AS4_RS11880	COG1846	Transcriptional regulator
AS4_RS11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_RS11920	COG0511	ligase activity, forming carbon-carbon bonds
AS4_RS11925	COG0439	Biotin carboxylase
AS4_RS11935	COG3706	GGDEF domain
AS4_RS11945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AS4_RS11955	COG1477	protein flavinylation
AS4_RS11965	COG0730	response to heat
AS4_RS11970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AS4_RS12005	COG1011	Hydrolase
AS4_RS12010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AS4_RS12015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AS4_RS12020	COG2137	regulation of response to DNA damage stimulus
AS4_RS12035	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_RS12045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_RS12055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_RS12070	COG0575	Belongs to the CDS family
AS4_RS12075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AS4_RS12080	COG0233	cytoplasmic translational termination
AS4_RS12095	COG3852	Histidine kinase
AS4_RS12100	COG2204	response regulator
AS4_RS12110	COG3753	Protein conserved in bacteria
AS4_RS12125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AS4_RS12130	COG4773	Receptor
AS4_RS12160	COG1132	(ABC) transporter
AS4_RS12190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AS4_RS12215	COG1294	oxidase, subunit
AS4_RS12220	COG4890	Cyd operon protein YbgT
AS4_RS12280	COG0659	secondary active sulfate transmembrane transporter activity
AS4_RS12290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_RS12310	COG0583	DNA-binding transcription factor activity
AS4_RS12315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AS4_RS12325	COG3135	benzoate transporter
AS4_RS12330	COG0024	Methionine aminopeptidase
AS4_RS12355	COG1253	flavin adenine dinucleotide binding
AS4_RS12375	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AS4_RS12395	COG0552	protein localization to endoplasmic reticulum
AS4_RS12400	COG0612	Peptidase, M16
AS4_RS12430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS4_RS12430	COG0517	IMP dehydrogenase activity
AS4_RS12435	COG0133	tryptophan synthase activity
AS4_RS12445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS4_RS12465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AS4_RS12495	COG0537	adenosine 5'-monophosphoramidase activity
AS4_RS12560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AS4_RS12565	COG1454	alcohol dehydrogenase
AS4_RS12575	COG0824	Thioesterase
AS4_RS12585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AS4_RS12625	COG0183	Belongs to the thiolase family
AS4_RS12635	COG1454	alcohol dehydrogenase
AS4_RS12650	COG3284	Transcriptional regulator
AS4_RS12670	COG0583	DNA-binding transcription factor activity
AS4_RS12695	COG1309	transcriptional regulator
AS4_RS12700	COG0519	Catalyzes the synthesis of GMP from XMP
AS4_RS12700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS4_RS12705	COG3042	response to heat
AS4_RS12735	COG4978	Transcriptional regulator
AS4_RS12735	COG0789	Transcriptional regulator
AS4_RS12775	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AS4_RS12780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AS4_RS12795	COG1280	lysine exporter protein (LysE YggA)
AS4_RS12820	COG1254	Belongs to the acylphosphatase family
AS4_RS12825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AS4_RS12825	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AS4_RS12850	COG1286	toxin biosynthetic process
AS4_RS12855	COG0167	dihydroorotate dehydrogenase activity
AS4_RS12880	COG0778	Nitroreductase
AS4_RS12890	COG0513	Belongs to the DEAD box helicase family
AS4_RS12895	COG1278	Cold shock
AS4_RS12910	COG2363	Small membrane protein
AS4_RS12940	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AS4_RS12945	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_RS12950	COG0625	glutathione transferase activity
AS4_RS12955	COG0659	secondary active sulfate transmembrane transporter activity
AS4_RS12965	COG4585	Histidine kinase
AS4_RS12975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_RS12980	COG1960	acyl-CoA dehydrogenase activity
AS4_RS13000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_RS13005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_RS13010	COG3781	membrane
AS4_RS13015	COG2890	protein-(glutamine-N5) methyltransferase activity
AS4_RS13020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AS4_RS13035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS13040	COG4682	membrane
AS4_RS13080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AS4_RS13085	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AS4_RS13090	COG1845	cytochrome c oxidase, subunit III
AS4_RS13095	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AS4_RS13120	COG0360	Binds together with S18 to 16S ribosomal RNA
AS4_RS13125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AS4_RS13135	COG0305	Participates in initiation and elongation during chromosome replication
AS4_RS13145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AS4_RS13160	COG1305	Transglutaminase-like
AS4_RS13170	COG2308	Evidence 4 Homologs of previously reported genes of
AS4_RS13210	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AS4_RS13215	COG0138	bifunctional purine biosynthesis protein purh
AS4_RS13220	COG0151	Belongs to the GarS family
AS4_RS13230	COG1464	Belongs to the NlpA lipoprotein family
AS4_RS13235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AS4_RS13240	COG2011	ABC-type metal ion transport system permease component
AS4_RS13350	COG3022	response to hydroperoxide
AS4_RS13360	COG4650	regulator
AS4_RS13365	COG1234	tRNA 3'-trailer cleavage
AS4_RS13385	COG1690	Belongs to the RtcB family
AS4_RS13405	COG0430	RNA-3'-phosphate cyclase activity
AS4_RS13425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AS4_RS13435	COG0693	protein deglycase activity
AS4_RS13445	COG1960	acyl-CoA dehydrogenase activity
AS4_RS13450	COG0616	signal peptide processing
AS4_RS13455	COG1301	dicarboxylic acid transport
AS4_RS13460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AS4_RS13470	COG0573	inorganic phosphate transmembrane transporter activity
AS4_RS13490	COG4122	O-methyltransferase activity
AS4_RS13580	COG1137	ATPase activity
AS4_RS13585	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AS4_RS13595	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AS4_RS13600	COG0517	IMP dehydrogenase activity
AS4_RS13600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AS4_RS13650	COG1671	Belongs to the UPF0178 family
AS4_RS13685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS13700	COG1301	dicarboxylic acid transport
AS4_RS13710	COG0463	Glycosyl transferase, family 2
AS4_RS13735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AS4_RS13735	COG0047	phosphoribosylformylglycinamidine synthase activity
AS4_RS13760	COG2255	four-way junction helicase activity
AS4_RS13765	COG4771	TonB-dependent receptor
AS4_RS13770	COG2031	fatty acid transporter
AS4_RS13790	COG0431	NADPH-dependent FMN reductase
AS4_RS13795	COG0798	PFAM Bile acid sodium symporter
AS4_RS13805	COG0640	Transcriptional regulator
AS4_RS13865	COG3299	homolog of phage Mu protein gp47
AS4_RS13910	COG4386	tail sheath protein
AS4_RS14030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AS4_RS14070	COG0824	Thioesterase
AS4_RS14095	COG0823	Involved in the tonB-independent uptake of proteins
AS4_RS14120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AS4_RS14145	COG0174	glutamine synthetase
AS4_RS14180	COG0582	viral genome integration into host DNA
AS4_RS14195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AS4_RS14205	COG3772	lysozyme
AS4_RS14415	COG0512	Glutamine amidotransferase of anthranilate synthase
AS4_RS14420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AS4_RS14435	COG0302	gtp cyclohydrolase
AS4_RS14455	COG4302	ethanolamine ammonia-lyase activity
AS4_RS14460	COG4303	Ethanolamine ammonia lyase large subunit
AS4_RS14465	COG0531	amino acid
AS4_RS14485	COG3739	integral membrane protein
AS4_RS14505	COG1741	Belongs to the pirin family
AS4_RS14510	COG0235	Class ii aldolase
AS4_RS14520	COG2233	PERMEase
AS4_RS14525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS14530	COG0251	oxidation-reduction process
AS4_RS14535	COG1335	isochorismatase
AS4_RS14540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS14545	COG0596	Alpha beta hydrolase
AS4_RS14585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_RS14595	COG0864	Transcriptional regulator
AS4_RS14600	COG0439	Biotin carboxylase
AS4_RS14615	COG0583	DNA-binding transcription factor activity
AS4_RS14620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AS4_RS14630	COG1724	mRNA binding
AS4_RS14635	COG1598	PFAM Uncharacterised protein family UPF0150
AS4_RS14640	COG4774	siderophore transport
AS4_RS14670	COG0583	DNA-binding transcription factor activity
AS4_RS14685	COG0251	oxidation-reduction process
AS4_RS14690	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS14700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AS4_RS14725	COG1629	transport
AS4_RS14805	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AS4_RS14830	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_RS14850	COG2267	carboxylic ester hydrolase activity
AS4_RS14875	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS14880	COG0028	Belongs to the TPP enzyme family
AS4_RS14910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AS4_RS14930	COG1113	amino acid transport
AS4_RS14935	COG1414	Transcriptional regulator
AS4_RS14940	COG2610	gluconate transmembrane transporter activity
AS4_RS14945	COG1454	alcohol dehydrogenase
AS4_RS14965	COG3188	usher protein
AS4_RS15015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_RS15045	COG2855	membrane
AS4_RS15065	COG3246	L-lysine catabolic process to acetate
AS4_RS15070	COG2175	clavaminate synthase activity
AS4_RS15100	COG0659	secondary active sulfate transmembrane transporter activity
AS4_RS15105	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AS4_RS15115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AS4_RS15135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS4_RS15140	COG1840	ABC-type Fe3 transport system, periplasmic component
AS4_RS15170	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_RS15170	COG1902	pentaerythritol trinitrate reductase activity
AS4_RS15180	COG0277	FAD linked oxidase domain protein
AS4_RS15190	COG2186	Transcriptional regulator
AS4_RS15200	COG0697	spore germination
AS4_RS15205	COG0583	DNA-binding transcription factor activity
AS4_RS15240	COG0477	Major facilitator Superfamily
AS4_RS15255	COG1960	acyl-CoA dehydrogenase activity
AS4_RS15300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AS4_RS15310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS4_RS15320	COG0280	phosphate acetyltransferase
AS4_RS15320	COG0281	malic enzyme
AS4_RS15330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AS4_RS15345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS4_RS15355	COG2351	hydroxyisourate hydrolase activity
AS4_RS15365	COG1686	Belongs to the peptidase S11 family
AS4_RS15370	COG1252	NADH dehydrogenase
AS4_RS15375	COG1047	Peptidyl-prolyl cis-trans
AS4_RS15380	COG0415	Belongs to the DNA photolyase family
AS4_RS15410	COG0667	Aldo Keto reductase
AS4_RS15420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AS4_RS15425	COG1381	Involved in DNA repair and RecF pathway recombination
AS4_RS15435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AS4_RS15440	COG0571	ribonuclease III activity
AS4_RS15470	COG4221	oxidoreductase activity
AS4_RS15475	COG0625	glutathione transferase activity
AS4_RS15490	COG0242	peptide deformylase activity
AS4_RS15500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AS4_RS15520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AS4_RS15535	COG2207	Transcriptional regulator
AS4_RS15565	COG2207	Transcriptional regulator
AS4_RS15580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AS4_RS15620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AS4_RS15630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AS4_RS15640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AS4_RS15645	COG4208	sulfate ABC transporter
AS4_RS15650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AS4_RS15655	COG0583	DNA-binding transcription factor activity
AS4_RS15675	COG0602	queuosine metabolic process
AS4_RS15680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AS4_RS15695	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS4_RS15705	COG0583	DNA-binding transcription factor activity
AS4_RS15710	COG0625	glutathione transferase activity
AS4_RS15720	COG2353	YceI-like domain
AS4_RS15725	COG1056	cytidyltransferase-related domain
AS4_RS15725	COG1051	belongs to the nudix hydrolase family
AS4_RS15730	COG1024	Enoyl-CoA hydratase
AS4_RS15735	COG0778	Nitroreductase
AS4_RS15740	COG3323	Protein of unknown function (DUF1653)
AS4_RS15740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AS4_RS15765	COG1280	lysine exporter protein (LysE YggA)
AS4_RS15770	COG1522	sequence-specific DNA binding
AS4_RS15775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AS4_RS15795	COG2234	aminopeptidase activity
AS4_RS15800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AS4_RS15805	COG3384	dioxygenase
AS4_RS15820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AS4_RS15825	COG2878	Part of a membrane complex involved in electron transport
AS4_RS15830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AS4_RS15860	COG0768	penicillin binding
AS4_RS15865	COG0742	ribosomal rna small subunit methyltransferase
AS4_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS15885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AS4_RS15895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS4_RS15910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AS4_RS15915	COG1053	succinate dehydrogenase
AS4_RS15920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AS4_RS15925	COG2009	succinate dehydrogenase
AS4_RS15955	COG2072	flavoprotein involved in K transport
AS4_RS15960	COG0300	oxidoreductase activity
AS4_RS16000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AS4_RS16005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AS4_RS16010	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AS4_RS16030	COG0505	Belongs to the CarA family
AS4_RS16035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AS4_RS16045	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AS4_RS16050	COG0110	maltose O-acetyltransferase activity
AS4_RS16055	COG1113	amino acid transport
AS4_RS16065	COG0625	glutathione transferase activity
AS4_RS16110	COG2321	neutral zinc metallopeptidase
AS4_RS16115	COG2354	Protein conserved in bacteria
AS4_RS16145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AS4_RS16150	COG1773	rubredoxin
AS4_RS16155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_RS16165	COG0583	DNA-binding transcription factor activity
AS4_RS16190	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AS4_RS16195	COG4181	ATPase activity
AS4_RS16215	COG0560	Phosphoserine phosphatase
AS4_RS16225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AS4_RS16235	COG0424	maF-like protein
AS4_RS16240	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AS4_RS16245	COG1792	Involved in formation and maintenance of cell shape
AS4_RS16250	COG1077	Cell shape determining protein MreB Mrl
AS4_RS16255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS4_RS16265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AS4_RS16280	COG2318	DinB family
AS4_RS16305	COG0583	DNA-binding transcription factor activity
AS4_RS16340	COG0523	cobalamin synthesis protein
AS4_RS16350	COG1469	GTP cyclohydrolase I activity
AS4_RS16360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AS4_RS16365	COG0789	Transcriptional regulator
AS4_RS16370	COG1902	pentaerythritol trinitrate reductase activity
AS4_RS16370	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_RS16375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS16410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS16415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_RS16420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_RS16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_RS16440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AS4_RS16470	COG1132	(ABC) transporter
AS4_RS16475	COG1132	(ABC) transporter
AS4_RS16495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AS4_RS16500	COG0601	transmembrane transport
AS4_RS16525	COG4774	siderophore transport
AS4_RS16530	COG4607	ABC-type enterochelin transport system periplasmic component
AS4_RS16535	COG4604	ABC transporter, ATP-binding protein
AS4_RS16540	COG4605	iron ion homeostasis
AS4_RS16545	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AS4_RS16550	COG1132	(ABC) transporter
AS4_RS16555	COG2375	cellular response to nickel ion
AS4_RS16555	COG1132	(ABC) transporter
AS4_RS16565	COG1063	alcohol dehydrogenase
AS4_RS16575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AS4_RS16580	COG0508	dehydrogenase complex catalyzes the overall conversion of
AS4_RS16585	COG0022	dehydrogenase e1 component
AS4_RS16590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AS4_RS16595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AS4_RS16610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS4_RS16615	COG1309	transcriptional regulator
AS4_RS16635	COG1309	transcriptional regulator
AS4_RS16640	COG2814	Major facilitator Superfamily
AS4_RS16660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_RS16670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AS4_RS16675	COG0235	Class ii aldolase
AS4_RS16680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AS4_RS16690	COG0028	Belongs to the TPP enzyme family
AS4_RS16705	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS16720	COG2271	Major facilitator Superfamily
AS4_RS16725	COG0446	pyridine nucleotide-disulphide oxidoreductase
AS4_RS16780	COG1733	regulation of RNA biosynthetic process
AS4_RS16805	COG0789	Transcriptional regulator
AS4_RS16815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS16820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AS4_RS16845	COG1595	DNA-templated transcription, initiation
AS4_RS16855	COG0583	DNA-binding transcription factor activity
AS4_RS16860	COG2610	gluconate transmembrane transporter activity
AS4_RS16870	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS16875	COG0583	DNA-binding transcription factor activity
AS4_RS16920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS4_RS16920	COG3008	intermembrane lipid transfer
AS4_RS16925	COG2995	paraquat-inducible protein a
AS4_RS16940	COG0477	Major facilitator Superfamily
AS4_RS16955	COG2274	protein secretion by the type I secretion system
AS4_RS16975	COG0583	DNA-binding transcription factor activity
AS4_RS16980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AS4_RS16985	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS16995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS4_RS17000	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS17005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS17010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AS4_RS17015	COG2267	carboxylic ester hydrolase activity
AS4_RS17050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_RS17060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_RS17065	COG1414	Transcriptional regulator
AS4_RS17070	COG2819	hydrolase of the alpha beta superfamily
AS4_RS17075	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AS4_RS17085	COG2985	domain, Protein
AS4_RS17105	COG3327	negative regulation of DNA-templated transcription, initiation
AS4_RS17110	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AS4_RS17115	COG0183	Belongs to the thiolase family
AS4_RS17120	COG1250	3-hydroxyacyl-CoA dehydrogenase
AS4_RS17125	COG1024	Enoyl-CoA hydratase
AS4_RS17130	COG1024	Enoyl-CoA hydratase
AS4_RS17135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AS4_RS17140	COG2151	metal-sulfur cluster biosynthetic enzyme
AS4_RS17145	COG3396	Phenylacetate-CoA oxygenase
AS4_RS17150	COG3460	Phenylacetate-CoA oxygenase
AS4_RS17155	COG3396	Phenylacetate-CoA oxygenase
AS4_RS17160	COG1012	belongs to the aldehyde dehydrogenase family
AS4_RS17160	COG2030	dehydratase
AS4_RS17165	COG0477	Major facilitator Superfamily
AS4_RS17215	COG3177	Filamentation induced by cAMP protein fic
AS4_RS17245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AS4_RS17250	COG0242	peptide deformylase activity
AS4_RS17265	COG3706	GGDEF domain
AS4_RS17280	COG1585	Membrane protein implicated in regulation of membrane protease activity
AS4_RS17285	COG2268	Band 7 protein
AS4_RS17300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AS4_RS17305	COG0523	cobalamin synthesis protein
AS4_RS17330	COG1280	lysine exporter protein (LysE YggA)
AS4_RS17340	COG1674	ftsk spoiiie
AS4_RS17340	COG0531	amino acid
AS4_RS17345	COG0492	ferredoxin-NADP+ reductase activity
AS4_RS17350	COG0500	methyltransferase
AS4_RS17355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AS4_RS17390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AS4_RS17400	COG0714	Associated with various cellular activities
AS4_RS17410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
AS4_RS17420	COG3831	ATPase activity
AS4_RS17425	COG3831	ATPase activity
AS4_RS17435	COG1981	membrane
AS4_RS17445	COG1113	amino acid transport
AS4_RS17475	COG0352	thiamine-phosphate diphosphorylase activity
AS4_RS17475	COG0351	phosphomethylpyrimidine kinase
AS4_RS17475	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AS4_RS17485	COG2207	Transcriptional regulator
AS4_RS17495	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AS4_RS17520	COG2132	Multicopper oxidase
AS4_RS17530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AS4_RS17540	COG4269	membrane
AS4_RS17545	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AS4_RS17560	COG1968	undecaprenyl-diphosphatase activity
AS4_RS17565	COG1214	PFAM Peptidase M22, glycoprotease
AS4_RS17570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AS4_RS17575	COG0494	nUDIX hydrolase
AS4_RS17625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AS4_RS17635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AS4_RS17660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_RS17665	COG0765	amino acid transport
AS4_RS17670	COG0765	amino acid transport
AS4_RS17675	COG1126	abc transporter atp-binding protein
AS4_RS17700	COG4716	Myosin-crossreactive antigen
AS4_RS17710	COG2226	methyltransferase
AS4_RS17740	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AS4_RS17745	COG2081	HI0933 family
AS4_RS17750	COG0668	transmembrane transport
AS4_RS17765	COG2814	Major facilitator Superfamily
AS4_RS17770	COG1289	transmembrane transporter activity
AS4_RS17835	COG2832	Protein of unknown function (DUF454)
AS4_RS17860	COG2198	Histidine kinase
AS4_RS17860	COG0643	Histidine kinase
AS4_RS17860	COG0784	Response regulator, receiver
AS4_RS17865	COG0840	transmembrane signaling receptor activity
AS4_RS17890	COG0442	prolyl-tRNA aminoacylation
AS4_RS17940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AS4_RS17945	COG0489	protein tyrosine kinase activity
AS4_RS17980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_RS17980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_RS18030	COG2199	diguanylate cyclase activity
AS4_RS18065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AS4_RS18080	COG0450	alkyl hydroperoxide reductase
AS4_RS18085	COG1652	LysM domain
AS4_RS18090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AS4_RS18110	COG1399	metal-binding, possibly nucleic acid-binding protein
AS4_RS18115	COG3101	peptidyl-lysine hydroxylation
AS4_RS18120	COG0009	L-threonylcarbamoyladenylate synthase
AS4_RS18140	COG0285	dihydrofolate synthase activity
AS4_RS18180	COG3152	Membrane
AS4_RS18190	COG0183	Belongs to the thiolase family
AS4_RS18200	COG0454	-acetyltransferase
AS4_RS18205	COG2207	Transcriptional regulator
AS4_RS18210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AS4_RS18225	COG0494	nUDIX hydrolase
AS4_RS18240	COG3422	double-strand break repair
AS4_RS18255	COG4106	trans-aconitate 2-methyltransferase activity
AS4_RS18270	COG2267	carboxylic ester hydrolase activity
AS4_RS18280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AS4_RS18290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AS4_RS18300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AS4_RS18310	COG1196	nuclear chromosome segregation
AS4_RS18320	COG0730	response to heat
AS4_RS18345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AS4_RS18360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AS4_RS18460	COG1272	protein, Hemolysin III
AS4_RS18465	COG0477	Major facilitator Superfamily
AS4_RS18475	COG0564	pseudouridine synthase activity
AS4_RS18485	COG1024	Enoyl-CoA hydratase
AS4_RS18490	COG1960	acyl-CoA dehydrogenase activity
AS4_RS18495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AS4_RS18500	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS18510	COG1309	transcriptional regulator
AS4_RS18530	COG1960	acyl-CoA dehydrogenase activity
AS4_RS18535	COG1960	acyl-CoA dehydrogenase activity
AS4_RS18540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AS4_RS18595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AS4_RS18600	COG1846	Transcriptional regulator
AS4_RS18605	COG1764	response to oxidative stress
AS4_RS18635	COG3384	dioxygenase
AS4_RS18645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AS4_RS18675	COG4206	TonB-dependent receptor
AS4_RS18680	COG2096	Adenosyltransferase
AS4_RS18700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AS4_RS18710	COG2315	Protein conserved in bacteria
AS4_RS18715	COG0745	RESPONSE REGULATOR receiver
AS4_RS18720	COG2205	protein histidine kinase activity
AS4_RS18730	COG3028	Belongs to the UPF0307 family
AS4_RS18735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AS4_RS18740	COG1660	Displays ATPase and GTPase activities
AS4_RS18745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AS4_RS18755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AS4_RS18760	COG0617	tRNA 3'-terminal CCA addition
AS4_RS18770	COG3956	TIGRFAM MazG family protein
AS4_RS18785	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AS4_RS18805	COG2205	protein histidine kinase activity
AS4_RS18805	COG0784	Response regulator, receiver
AS4_RS18805	COG5002	protein histidine kinase activity
AS4_RS18810	COG1024	Enoyl-CoA hydratase
AS4_RS18815	COG2084	Dehydrogenase
AS4_RS18820	COG3622	Belongs to the hyi family
AS4_RS18830	COG0004	ammonium transporteR
AS4_RS18865	COG1426	Protein conserved in bacteria
AS4_RS18890	COG0671	phosphoesterase, PA-phosphatase related
AS4_RS18915	COG0440	acetolactate synthase activity
AS4_RS18920	COG0028	Belongs to the TPP enzyme family
AS4_RS18945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AS4_RS18950	COG1136	(ABC) transporter
AS4_RS18950	COG0577	efflux transmembrane transporter activity
AS4_RS18955	COG1538	Outer membrane efflux protein
AS4_RS19005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AS4_RS19010	COG1162	GTPase activity
AS4_RS19020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AS4_RS19055	COG3783	Cytochrome b(562)
AS4_RS19060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AS4_RS19065	COG2003	Belongs to the UPF0758 family
AS4_RS19070	COG3781	membrane
AS4_RS19105	COG1946	Acyl-CoA thioesterase
AS4_RS19120	COG1295	ribonuclease BN
AS4_RS19130	COG0179	Fumarylacetoacetate (FAA) hydrolase
AS4_RS19155	COG2814	Major facilitator Superfamily
AS4_RS19165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_RS19170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AS4_RS19175	COG1126	abc transporter atp-binding protein
AS4_RS19180	COG0765	amino acid transport
AS4_RS19185	COG0765	amino acid transport
AS4_RS19215	COG0557	exoribonuclease II activity
AS4_RS19225	COG0339	signal peptide processing
AS4_RS19230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AS4_RS19270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AS4_RS19275	COG1960	acyl-CoA dehydrogenase activity
AS4_RS19280	COG2072	flavoprotein involved in K transport
AS4_RS19285	COG0203	ribosomal protein L17
AS4_RS19290	COG0202	RNA polymerase activity
AS4_RS19295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AS4_RS19330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AS4_RS19345	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AS4_RS19365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AS4_RS19395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AS4_RS19410	COG0088	Forms part of the polypeptide exit tunnel
AS4_RS19415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AS4_RS19420	COG0051	transcription antitermination factor activity, RNA binding
AS4_RS19435	COG0433	COG0433 Predicted ATPase
AS4_RS19445	COG1959	2 iron, 2 sulfur cluster binding
AS4_RS19460	COG1301	dicarboxylic acid transport
AS4_RS19465	COG1946	Acyl-CoA thioesterase
AS4_RS19470	COG2937	Belongs to the GPAT DAPAT family
AS4_RS19485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AS4_RS19490	COG1040	competence protein
AS4_RS19505	COG0598	Magnesium transport protein CorA
AS4_RS19520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AS4_RS19525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AS4_RS19530	COG1127	ABC transporter
AS4_RS19535	COG0513	Belongs to the DEAD box helicase family
AS4_RS19545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AS4_RS19550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AS4_RS19560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS4_RS19565	COG0408	coproporphyrinogen oxidase activity
AS4_RS19585	COG1960	acyl-CoA dehydrogenase activity
AS4_RS19595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AS4_RS19605	COG0534	Mate efflux family protein
AS4_RS19615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS4_RS19620	COG0254	rRNA binding
AS4_RS19625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AS4_RS19655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AS4_RS19660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AS4_RS19675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AS4_RS19685	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AS4_RS19685	COG0644	oxidoreductase
AS4_RS19705	COG0425	Belongs to the sulfur carrier protein TusA family
AS4_RS19710	COG4535	Mg2 and Co2 transporter CorC
AS4_RS19715	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AS4_RS19720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_RS19720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AS4_RS19745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AS4_RS19765	COG0475	glutathione-regulated potassium exporter activity
AS4_RS19765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AS4_RS19770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AS4_RS19780	COG0789	Transcriptional regulator
AS4_RS19785	COG2841	Protein conserved in bacteria
AS4_RS19790	COG0598	Magnesium transport protein CorA
AS4_RS19795	COG1185	polyribonucleotide nucleotidyltransferase activity
AS4_RS19805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AS4_RS19810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AS4_RS19815	COG1074	ATP-dependent DNA helicase activity
AS4_RS19820	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AS4_RS19840	COG2271	Major facilitator Superfamily
AS4_RS19845	COG1335	isochorismatase
AS4_RS19850	COG3473	Maleate cis-trans isomerase
AS4_RS19855	COG0596	Alpha beta hydrolase
AS4_RS19860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AS4_RS19865	COG2309	aminopeptidase activity
AS4_RS19870	COG1846	Transcriptional regulator
AS4_RS19895	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AS4_RS19910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AS4_RS19930	COG2111	Na H antiporter
AS4_RS19930	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AS4_RS19935	COG1006	Multisubunit Na H antiporter MnhC subunit
AS4_RS19940	COG0651	ATP synthesis coupled electron transport
AS4_RS19945	COG1863	multisubunit Na H antiporter MnhE subunit
AS4_RS19950	COG2212	antiporter activity
AS4_RS19955	COG1320	monovalent cation:proton antiporter activity
AS4_RS19960	COG0307	riboflavin synthase, alpha
AS4_RS19970	COG1733	regulation of RNA biosynthetic process
AS4_RS19975	COG2249	NAD(P)H dehydrogenase (quinone) activity
AS4_RS19980	COG0493	'glutamate synthase
AS4_RS19985	COG0070	glutamate synthase
AS4_RS19985	COG0067	glutamate synthase
AS4_RS19985	COG0069	glutamate synthase activity
AS4_RS20035	COG2226	methyltransferase
AS4_RS20040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AS4_RS20045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AS4_RS20050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AS4_RS20060	COG3116	cell division
AS4_RS20090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS4_RS20145	COG4221	oxidoreductase activity
AS4_RS20175	COG0789	Transcriptional regulator
AS4_RS20200	COG0427	acetyl-CoA hydrolase
AS4_RS20245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AS4_RS20275	COG0697	spore germination
AS4_RS20290	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AS4_RS20305	COG0488	(ABC) transporter
AS4_RS20325	COG0704	Plays a role in the regulation of phosphate uptake
AS4_RS20350	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AS4_RS20355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AS4_RS20360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AS4_RS20370	COG0772	Belongs to the SEDS family
AS4_RS20380	COG0586	Pfam SNARE associated Golgi protein
AS4_RS20395	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS4_RS20395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AS4_RS20405	COG0004	ammonium transporteR
AS4_RS20410	COG0347	Belongs to the P(II) protein family
AS4_RS20420	COG0606	chelatase, subunit chli
AS4_RS20450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AS4_RS20465	COG0318	PFAM AMP-dependent synthetase and ligase
AS4_RS20480	COG0477	Major facilitator Superfamily
AS4_RS20490	COG2860	membrane
AS4_RS20495	COG3012	SEC-C Motif Domain Protein
AS4_RS20500	COG1253	flavin adenine dinucleotide binding
AS4_RS20545	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AS4_RS20555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AS4_RS20560	COG3162	membrane
AS4_RS20565	COG2205	protein histidine kinase activity
AS4_RS20565	COG0784	Response regulator, receiver
AS4_RS20585	COG2133	pyrroloquinoline quinone binding
AS4_RS20625	COG1309	transcriptional regulator
AS4_RS20660	COG1652	LysM domain
AS4_RS20665	COG0758	DNA mediated transformation
AS4_RS20670	COG0009	L-threonylcarbamoyladenylate synthase
AS4_RS20675	COG0697	spore germination
AS4_RS20680	COG1309	transcriptional regulator
AS4_RS20700	COG0386	Belongs to the glutathione peroxidase family
AS4_RS20735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AS4_RS20745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AS4_RS20775	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AS4_RS20785	COG1121	(ABC) transporter
AS4_RS20790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AS4_RS20805	COG2837	iron assimilation
AS4_RS20830	COG0281	malic enzyme
AS4_RS20860	COG0745	RESPONSE REGULATOR receiver
AS4_RS20865	COG2205	protein histidine kinase activity
AS4_RS20870	COG4452	Inner membrane protein CreD
AS4_RS20895	COG2814	Major facilitator Superfamily
AS4_RS20905	COG0431	NADPH-dependent FMN reductase
AS4_RS20925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AS4_RS20935	COG0668	transmembrane transport
AS4_RS20940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AS4_RS20945	COG1519	Transferase
AS4_RS20950	COG1902	pentaerythritol trinitrate reductase activity
AS4_RS20980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AS4_RS20980	COG0519	Catalyzes the synthesis of GMP from XMP
AS4_RS20985	COG2259	Doxx family
AS4_RS20990	COG0586	Pfam SNARE associated Golgi protein
AS4_RS21000	COG1192	Involved in chromosome partitioning
AS4_RS21010	COG0271	Belongs to the BolA IbaG family
AS4_RS21045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AS4_RS21050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AS4_RS21055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AS4_RS21070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AS4_RS21075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AS4_RS21090	COG0110	maltose O-acetyltransferase activity
AS4_RS21095	COG1215	transferase activity, transferring glycosyl groups
AS4_RS21130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AS4_RS21160	COG1596	polysaccharide export
AS4_RS21185	COG0728	peptidoglycan biosynthetic process
AS4_RS21190	COG3023	N-Acetylmuramoyl-L-alanine amidase
AS4_RS21215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AS4_RS21225	COG2207	Transcriptional regulator
AS4_RS21250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AS4_RS21255	COG0546	phosphoglycolate phosphatase activity
AS4_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
AS4_RS21280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AS4_RS21280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AS4_RS21285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_RS21290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AS4_RS21295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AS4_RS21300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_RS21305	COG1116	anion transmembrane transporter activity
AS4_RS21310	COG1309	transcriptional regulator
AS4_RS21455	COG0737	Belongs to the 5'-nucleotidase family
AS4_RS21460	COG2175	clavaminate synthase activity
AS4_RS21465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AS4_RS21470	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AS4_RS21475	COG4521	taurine ABC transporter
AS4_RS21505	COG0443	Heat shock 70 kDa protein
AS4_RS21540	COG2951	lytic endotransglycosylase activity
AS4_RS21545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AS4_RS21565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AS4_RS21580	COG2388	GCN5-related N-acetyl-transferase
AS4_RS21585	COG2814	Major facilitator Superfamily
AS4_RS21595	COG0861	Integral membrane protein TerC family
AS4_RS21605	COG0402	S-adenosylhomocysteine deaminase activity
AS4_RS21615	COG2261	transglycosylase associated protein
AS4_RS21625	COG1230	cation diffusion facilitator family transporter
AS4_RS21650	COG0706	membrane insertase activity
AS4_RS21655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AS4_RS21660	COG0594	ribonuclease P activity