locus-tag class description FPL18_RS00015 ENOG4105CNA YD repeat protein FPL18_RS00020 ENOG4105CS6 Rhs element vgr protein FPL18_RS00030 ENOG4107QUV Domain protein FPL18_RS00050 ENOG4105CUB amino acid FPL18_RS00055 ENOG4105CPD ethanolamine ammonia-lyase FPL18_RS00065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL18_RS00080 ENOG4106HB6 Alpha beta hydrolase FPL18_RS00085 ENOG4105CX6 glutaminyL-tRNA synthetase FPL18_RS00095 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) FPL18_RS00115 ENOG4108RCM Nitroreductase FPL18_RS00130 ENOG4108TZV Membrane FPL18_RS00135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL18_RS00145 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FPL18_RS00150 ENOG4105K8N protein family UPF0079, ATPase FPL18_RS00175 ENOG4105I08 Pseudouridine synthase FPL18_RS00185 ENOG4105DEN Luciferase family FPL18_RS00190 ENOG4105BZU Histidine kinase FPL18_RS00210 ENOG4105E2S oxidase) subunit II FPL18_RS00215 ENOG4105BZ9 Cytochrome C oxidase, subunit I FPL18_RS00220 ENOG4105CCU oxidase (Subunit III) FPL18_RS00225 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FPL18_RS00255 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FPL18_RS00260 ENOG4105KVH Transcriptional regulator FPL18_RS00265 ENOG4105CDU Replicative dna helicase FPL18_RS00270 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FPL18_RS00310 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FPL18_RS00330 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FPL18_RS00340 ENOG4105CFH Aspartokinase FPL18_RS00350 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FPL18_RS00360 ENOG4105CPW cytochrome b561 FPL18_RS00365 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) FPL18_RS00370 ENOG4105C7N Xanthine uracil vitamin C permease FPL18_RS00430 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FPL18_RS00435 ENOG4105DC1 bifunctional purine biosynthesis protein purh FPL18_RS00440 ENOG4105C12 Phosphoribosylglycinamide synthetase FPL18_RS00450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FPL18_RS00455 ENOG4108UMI ABC transporter, permease FPL18_RS00460 ENOG4108NIW Leucine export protein LeuE FPL18_RS00475 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FPL18_RS00485 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) FPL18_RS00490 ENOG4105SYT Methylenetetrahydrofolate reductase FPL18_RS00495 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FPL18_RS00500 ENOG4105BZU Histidine kinase FPL18_RS00505 ENOG4105C6K Malic enzyme FPL18_RS00530 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase FPL18_RS00535 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FPL18_RS00540 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) FPL18_RS00550 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FPL18_RS00555 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FPL18_RS00565 ENOG4105C3F Signal peptidase i FPL18_RS00570 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FPL18_RS00585 ENOG4105C0H protease FPL18_RS00590 ENOG4108IYU L-aspartate oxidase FPL18_RS00600 ENOG4105HHA aminodeoxychorismate lyase FPL18_RS00605 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FPL18_RS00610 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FPL18_RS00620 ENOG4108I5D sulfate abc transporter FPL18_RS00630 ENOG4108IJ6 ABC transporter FPL18_RS00635 ENOG4107R11 Transcriptional regulator FPL18_RS00650 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FPL18_RS00655 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FPL18_RS00670 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL18_RS00690 ENOG41060WC Enoyl-CoA hydratase FPL18_RS00695 ENOG4105BZW Glycerate kinase FPL18_RS00700 ENOG4105EGD dinuclear metal center protein, YbgI family FPL18_RS00735 ENOG4105C2C drug resistance transporter, Bcr CflA FPL18_RS00740 ENOG4108ETH Formylglycinamide ribotide synthetase FPL18_RS00780 ENOG4107YD3 Thioesterase FPL18_RS00785 ENOG4105E02 MotA TolQ exbB proton channel FPL18_RS00790 ENOG4105M8F Biopolymer transport protein exbD tolR FPL18_RS00800 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) FPL18_RS00805 ENOG4105KCK Peptidoglycan-associated lipoprotein FPL18_RS00855 ENOG4105C02 permease FPL18_RS00865 ENOG4108V3E phosphoribosylglycinamide formyltransferase FPL18_RS00875 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FPL18_RS00885 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FPL18_RS00890 ENOG4105D60 lipoprotein releasing system transmembrane protein FPL18_RS00895 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FPL18_RS00950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL18_RS00955 ENOG4105C10 Electron transfer flavoprotein FPL18_RS00960 ENOG4105BZJ Electron transfer flavoprotein FPL18_RS00965 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL18_RS00970 ENOG4105N14 lysine exporter protein LysE YggA FPL18_RS00975 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FPL18_RS00980 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FPL18_RS00990 ENOG4105C85 amino acid FPL18_RS00995 ENOG4105BZG amino acid carrier protein FPL18_RS01000 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FPL18_RS01010 ENOG4105CJ3 phosphate transporter FPL18_RS01015 ENOG4105C3R Methionine synthase FPL18_RS01020 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FPL18_RS01030 ENOG4105CSV Glutaminase FPL18_RS01035 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL18_RS01055 ENOG4108U51 Universal stress protein FPL18_RS01080 ENOG4107R72 Ceramidase FPL18_RS01095 ENOG4105E2B Taurine dioxygenase FPL18_RS01100 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL18_RS01105 ENOG4108IY8 ABC, transporter FPL18_RS01110 ENOG4106FTQ Taurine ABC transporter, periplasmic FPL18_RS01120 ENOG4105D7W serine acetyltransferase FPL18_RS01125 ENOG4105ESN nucleotide-binding protein FPL18_RS01130 ENOG4105C9B Cysteine desulfurase FPL18_RS01140 ENOG4105EXG Transcriptional regulator FPL18_RS01145 ENOG4105FDP GntR family transcriptional regulator FPL18_RS01150 ENOG4108IYU L-aspartate oxidase FPL18_RS01165 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL18_RS01185 ENOG4105PGM cation diffusion facilitator family transporter FPL18_RS01195 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FPL18_RS01200 ENOG4105E0C molybdate abc transporter FPL18_RS01205 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FPL18_RS01275 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL18_RS01305 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FPL18_RS01315 ENOG4105CEY Amp-dependent synthetase and ligase FPL18_RS01325 ENOG4105DY2 Paraquat-inducible protein b FPL18_RS01330 ENOG4105F1S paraquat-inducible protein a FPL18_RS01340 ENOG4108IQI permease FPL18_RS01350 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FPL18_RS01355 ENOG4105C26 Dehydrogenase FPL18_RS01360 ENOG4105F4X arginine FPL18_RS01365 ENOG4105C8Y Acetylornithine aminotransferase FPL18_RS01370 ENOG4105D82 Glutamate dehydrogenase FPL18_RS01380 ENOG4107R1I NAD-dependent malic enzyme FPL18_RS01415 ENOG4107QPN acyl-Coa dehydrogenase FPL18_RS01420 ENOG4105EPF Outer membrane porin FPL18_RS01425 ENOG4108KB2 LysR family Transcriptional regulator FPL18_RS01430 ENOG4105DTQ mandelate racemase muconate lactonizing FPL18_RS01435 ENOG4105NN7 muconolactone delta-isomerase FPL18_RS01445 ENOG4107QP7 CoA-transferase subunit A FPL18_RS01450 ENOG4107QNJ CoA-transferase subunit B FPL18_RS01455 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS01460 ENOG4105F2Z 3-oxoadipate enol-lactonase FPL18_RS01465 ENOG4105C26 Dehydrogenase FPL18_RS01480 ENOG4105F11 amine oxidase FPL18_RS01500 ENOG4105CHR reductase FPL18_RS01510 ENOG4105FUY alpha subunit FPL18_RS01525 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FPL18_RS01535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FPL18_RS01540 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FPL18_RS01550 ENOG4105JHE Major Facilitator Superfamily FPL18_RS01570 ENOG4105CHR reductase FPL18_RS01610 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL18_RS01695 ENOG4105CNA YD repeat protein FPL18_RS01700 ENOG4105CS6 Rhs element vgr protein FPL18_RS01715 ENOG4108IPW abc transporter atp-binding protein FPL18_RS01740 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) FPL18_RS01745 ENOG4105CNM Receptor FPL18_RS01750 ENOG4108Z4X TRANSCRIPTIONal FPL18_RS01760 ENOG410624X efflux transporter, rnd family, mfp subunit FPL18_RS01765 ENOG4105BZS acriflavin resistance protein FPL18_RS01780 ENOG4105F95 Monooxygenase FPL18_RS01800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL18_RS01805 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) FPL18_RS01810 ENOG4108IXY short-chain dehydrogenase reductase FPL18_RS01815 ENOG4108ZX5 transcriptional regulator FPL18_RS01820 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL18_RS01825 ENOG4105FB2 class II Aldolase FPL18_RS01830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS01865 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FPL18_RS01880 ENOG4105CVR type I restriction-modification system FPL18_RS01885 ENOG4106P55 Transcriptional regulator FPL18_RS01900 ENOG4106P55 Transcriptional regulator FPL18_RS01905 ENOG4107EFR Flavocytochrome c FPL18_RS01940 ENOG4105EMU Dehydrogenase FPL18_RS01960 ENOG4105BZS acriflavin resistance protein FPL18_RS01965 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL18_RS01980 ENOG4105D1S lipid A biosynthesis FPL18_RS01995 ENOG4105MXB limonene-12-epoxide hydrolase FPL18_RS02030 ENOG4105EQ2 LysR family Transcriptional regulator FPL18_RS02035 ENOG4105ENX hydrolase FPL18_RS02055 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL18_RS02060 ENOG4105CW7 secretion protein, HlyD family FPL18_RS02070 ENOG4105D2S major facilitator superfamily FPL18_RS02075 ENOG4105F57 Anthranilate dioxygenase reductase FPL18_RS02080 ENOG4108YS2 small subunit FPL18_RS02085 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit FPL18_RS02090 ENOG4108VUY thioesterase Superfamily protein FPL18_RS02095 ENOG4105D52 delta-aminolevulinic acid dehydratase FPL18_RS02100 ENOG4108DN8 FAD dependent oxidoreductase FPL18_RS02120 ENOG4105E9F Enoyl-CoA hydratase FPL18_RS02125 ENOG4107RH8 nuclease SbcCD subunit D FPL18_RS02130 ENOG4105EYH Exonuclease FPL18_RS02135 ENOG4105PAD Hydrolase FPL18_RS02145 ENOG4105DFA alanine racemase domain protein FPL18_RS02150 ENOG4105CZX twitching motility protein FPL18_RS02155 ENOG4105CZX twitching motility protein FPL18_RS02160 ENOG41090R7 Ferric uptake FPL18_RS02190 ENOG4105E7A Glutamine amidotransferase FPL18_RS02210 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FPL18_RS02215 ENOG4105C4R Atp-dependent dna helicase FPL18_RS02220 ENOG4108ZG0 Ompa motb domain protein FPL18_RS02225 ENOG4106HNH Acyl-transferase FPL18_RS02235 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FPL18_RS02240 ENOG4107QMS site-determining protein FPL18_RS02255 ENOG4105CNU cell division protein FtsK FPL18_RS02260 ENOG4105C3M thioredoxin reductase FPL18_RS02270 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) FPL18_RS02280 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FPL18_RS02300 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FPL18_RS02325 ENOG4108YXA Membrane FPL18_RS02345 ENOG4105C4K Nad synthetase FPL18_RS02370 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FPL18_RS02390 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FPL18_RS02395 ENOG4105C34 Pseudouridine synthase FPL18_RS02400 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FPL18_RS02405 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FPL18_RS02420 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) FPL18_RS02450 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FPL18_RS02485 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FPL18_RS02490 ENOG4107XGZ Hydrolase FPL18_RS02495 ENOG4105DWF phosphomethylpyrimidine kinase FPL18_RS02500 ENOG4109066 lysm domain bon superfamily protein FPL18_RS02510 ENOG4105CHR reductase FPL18_RS02515 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FPL18_RS02520 ENOG4105VGS 50s ribosomal protein l32 FPL18_RS02525 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FPL18_RS02530 ENOG4108BPE -transporting atpase FPL18_RS02535 ENOG4107RTD sua5 ycio yrdc ywlc family protein FPL18_RS02550 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FPL18_RS02555 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FPL18_RS02560 ENOG4105FE9 pseudouridine synthase FPL18_RS02580 ENOG4105DGW oligopeptidase A FPL18_RS02590 ENOG4105DIB Oligopeptide-binding protein FPL18_RS02630 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL18_RS02635 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FPL18_RS02640 ENOG4105C8Y Acetylornithine aminotransferase FPL18_RS02645 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL18_RS02655 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL18_RS02660 ENOG4108KB2 LysR family Transcriptional regulator FPL18_RS02665 ENOG4105FUY alpha subunit FPL18_RS02670 ENOG4108UKV benzoate 1,2-dioxygenase FPL18_RS02675 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein FPL18_RS02680 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase FPL18_RS02685 ENOG4105DKK Benzoate FPL18_RS02690 ENOG4105D2S major facilitator superfamily FPL18_RS02710 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FPL18_RS02720 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FPL18_RS02740 ENOG4105HF0 Membrane FPL18_RS02760 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FPL18_RS02770 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FPL18_RS02845 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FPL18_RS02850 ENOG4105D1F ATP-binding protein FPL18_RS02865 ENOG4108YYQ gCN5-related N-acetyltransferase FPL18_RS02885 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FPL18_RS02895 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FPL18_RS02920 ENOG4105F2W methyltransferase FPL18_RS02945 ENOG4105K6H D-cysteine desulfhydrase FPL18_RS02950 ENOG4105CBX hi0933 family FPL18_RS02980 ENOG4105DP0 ferredoxin-NADP reductase FPL18_RS02985 ENOG4105DUM transcriptional regulator, lysR family FPL18_RS03010 ENOG4105C8S subunit m FPL18_RS03015 ENOG4105D65 subunit l FPL18_RS03020 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL18_RS03025 ENOG4107UFS subunit j FPL18_RS03030 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL18_RS03040 ENOG4108IEH NADH dehydrogenase subunit g FPL18_RS03045 ENOG4107QIZ NADH dehydrogenase FPL18_RS03050 ENOG4105GKE subunit e FPL18_RS03055 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL18_RS03065 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FPL18_RS03070 ENOG4105BZU Histidine kinase FPL18_RS03080 ENOG4105JJR Histidine kinase FPL18_RS03085 ENOG4107EXC regulatoR FPL18_RS03095 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL18_RS03105 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL18_RS03115 ENOG41082JN Transcriptional regulator FPL18_RS03125 ENOG4105J7D transcriptional regulator FPL18_RS03145 ENOG4105KG1 l-proline 3-hydroxylase FPL18_RS03160 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FPL18_RS03195 ENOG4105C94 Transporter FPL18_RS03200 ENOG4105C94 Transporter FPL18_RS03205 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FPL18_RS03230 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FPL18_RS03295 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FPL18_RS03300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FPL18_RS03305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FPL18_RS03330 ENOG4105E3B Multicopper oxidase FPL18_RS03340 ENOG4105DJV ribulose-phosphate 3-epimerase FPL18_RS03370 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FPL18_RS03375 ENOG41072GX Peptidase M22 Glycoprotease FPL18_RS03385 ENOG4105P8F nudix hydrolase FPL18_RS03425 ENOG4105CRQ synthase (Component I) FPL18_RS03435 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FPL18_RS03445 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FPL18_RS03450 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FPL18_RS03525 ENOG4105K56 Transcriptional regulator FPL18_RS03530 ENOG4108ZHJ Organic hydroperoxide resistance protein FPL18_RS03535 ENOG4107QHF type ii secretion system protein e FPL18_RS03555 ENOG4105C2M dna polymerase I FPL18_RS03560 ENOG4105EXC Acyl-transferase FPL18_RS03565 ENOG4108VIA integral membrane protein FPL18_RS03570 ENOG4105II7 pyrroline-5-carboxylate reductase FPL18_RS03575 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FPL18_RS03585 ENOG4105C9X ppx gppa phosphatase FPL18_RS03595 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FPL18_RS03610 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FPL18_RS03645 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FPL18_RS03660 ENOG4105W39 Membrane FPL18_RS03675 ENOG4105CYM Glutathione S-transferase FPL18_RS03695 ENOG4105CEY Amp-dependent synthetase and ligase FPL18_RS03700 ENOG4105N42 UPF0307 protein FPL18_RS03725 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FPL18_RS03730 ENOG4105DJ0 Poly(A) Polymerase FPL18_RS03735 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FPL18_RS03740 ENOG4105DXN mazG family FPL18_RS03765 ENOG4105C6T cysteine synthase FPL18_RS03770 ENOG4105BZU Histidine kinase FPL18_RS03785 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL18_RS03790 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FPL18_RS03810 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FPL18_RS03815 ENOG4105W8H transhydrogenase (subunit alpha FPL18_RS03820 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FPL18_RS03840 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FPL18_RS03845 ENOG4105NI8 Cytosine-specific methyltransferase FPL18_RS03865 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL18_RS03880 ENOG4105CUZ uba thif-type nad fad binding protein FPL18_RS03890 ENOG4107QM5 aconitate hydratase FPL18_RS03895 ENOG4105F8V Hydrolase, tatD family FPL18_RS03900 ENOG4108ZJ4 polysaccharide deacetylase FPL18_RS03910 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) FPL18_RS03945 ENOG4105EMY transcriptional regulator FPL18_RS03985 ENOG4105CAU Arsenical resistance protein, ArsH FPL18_RS03990 ENOG4105D6J arsenicaL-resistance protein FPL18_RS03995 ENOG41082YX Transcriptional regulator, arsr family FPL18_RS04015 ENOG4105VZ8 Transcriptional regulator FPL18_RS04030 ENOG4105BZU Histidine kinase FPL18_RS04040 ENOG4108ZP8 Acetolactate synthase small subunit FPL18_RS04045 ENOG4105C7K acetolactate synthase FPL18_RS04065 ENOG4105JF9 DNA polymerase III, delta FPL18_RS04070 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FPL18_RS04075 ENOG4105DJY efflux transporter, rnd family, mfp subunit FPL18_RS04080 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL18_RS04085 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL18_RS04095 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FPL18_RS04105 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) FPL18_RS04110 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FPL18_RS04120 ENOG4105VW4 glutaredoxin 3 FPL18_RS04160 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FPL18_RS04170 ENOG4105FFC UPF0187 protein FPL18_RS04175 ENOG4105CPC Aldo Keto reductase FPL18_RS04180 ENOG4105EJC lysr family transcriptional regulator FPL18_RS04185 ENOG4105DB7 PHP domain protein FPL18_RS04215 ENOG4108VPT UPF0234 protein FPL18_RS04230 ENOG4108ZGC gaf domain protein FPL18_RS04235 ENOG4105NAU thioesterase Superfamily protein FPL18_RS04245 ENOG4107U2T alpha beta FPL18_RS04250 ENOG4107QPB Beta-lactamase domain protein FPL18_RS04290 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL18_RS04295 ENOG4105D6S protein involved in catabolism of external DNA FPL18_RS04325 ENOG4105E4C Lytic transglycosylase catalytic FPL18_RS04335 ENOG4105C9A Phoh family FPL18_RS04350 ENOG4105CNM Receptor FPL18_RS04375 ENOG4108XI2 Domain of unknown function (DUF1963) FPL18_RS04380 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FPL18_RS04420 ENOG4105CIY formyltetrahydrofolate deformylase FPL18_RS04425 ENOG41062JF Transcriptional regulator FPL18_RS04430 ENOG4107RGH Aldehyde dehydrogenase FPL18_RS04435 ENOG4105KDC 50s ribosomal protein l28 FPL18_RS04440 ENOG4105W0E 50S ribosomal protein L33 FPL18_RS04445 ENOG4105CKD glutathione-regulated potassium-efflux system protein FPL18_RS04470 ENOG4105VFU Rna-binding protein FPL18_RS04475 ENOG4105C4R Atp-dependent dna helicase FPL18_RS04490 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FPL18_RS04500 ENOG4105KVH Transcriptional regulator FPL18_RS04505 ENOG4105CIS alcohol dehydrogenase FPL18_RS04510 ENOG41069P5 Protein slyX homolog FPL18_RS04515 ENOG4105C5H ABC transporter FPL18_RS04520 ENOG4108UVJ appr-1-p processing domain protein FPL18_RS04525 ENOG4105D1S lipid A biosynthesis FPL18_RS04600 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FPL18_RS04615 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FPL18_RS04650 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FPL18_RS04655 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FPL18_RS04665 ENOG4105CH6 catalase FPL18_RS04685 ENOG4108W5M transcriptional regulator FPL18_RS04705 ENOG4105EI2 Pseudouridine synthase FPL18_RS04715 ENOG4105C03 ribonuclease FPL18_RS04735 ENOG4105CSA Coproporphyrinogen iii oxidase FPL18_RS04745 ENOG4107QI1 Mate efflux family protein FPL18_RS04780 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FPL18_RS04785 ENOG4108IND Tetr family transcriptional regulator FPL18_RS04790 ENOG4105EW6 flavin reductase domain protein, FMN-binding FPL18_RS04805 ENOG4105BZ8 glutamate synthase FPL18_RS04815 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) FPL18_RS04820 ENOG4105C5X domain protein FPL18_RS04835 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FPL18_RS04845 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FPL18_RS04850 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) FPL18_RS04855 ENOG4108JU5 Magnesium and cobalt efflux protein FPL18_RS04860 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FPL18_RS04865 ENOG4108Z7R Chaperone CsaA FPL18_RS04880 ENOG4108VAU general secretion pathway protein G FPL18_RS04885 ENOG4105D7Q type ii secretion system FPL18_RS04890 ENOG4105C25 Primosomal protein n' FPL18_RS04895 ENOG4105CKD glutathione-regulated potassium-efflux system protein FPL18_RS04900 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FPL18_RS04915 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) FPL18_RS04920 ENOG4107QUT magnesium and cobalt transport protein CorA FPL18_RS04925 ENOG4105CK2 sodium dicarboxylate symporter FPL18_RS04930 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FPL18_RS04935 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FPL18_RS04945 ENOG4107QYX exodeoxyribonuclease v alpha FPL18_RS04950 ENOG4107QKA exodeoxyribonuclease V beta FPL18_RS04955 ENOG4105DSY exodeoxyribonuclease V, gamma FPL18_RS04970 ENOG4105CSR polyphosphate kinase 2 FPL18_RS04980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL18_RS04990 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) FPL18_RS04995 ENOG4105CPW cytochrome b561 FPL18_RS05005 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FPL18_RS05010 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FPL18_RS05020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL18_RS05025 ENOG4105D65 subunit l FPL18_RS05030 ENOG4108ZE9 Monovalent cation H antiporter subunit C FPL18_RS05035 ENOG4107R4Z monovalent cation h antiporter subunit d FPL18_RS05040 ENOG4105SC1 monovalent cation H antiporter subunit E FPL18_RS05045 ENOG4105W4C monovalent cation H antiporter subunit F FPL18_RS05050 ENOG4105KJM monovalent cation h antiporter subunit g FPL18_RS05055 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FPL18_RS05065 ENOG4105CHV Transcription elongation factor NusA FPL18_RS05100 ENOG4107QHF type ii secretion system protein e FPL18_RS05115 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FPL18_RS05125 ENOG4105C2N RNA methyltransferase TrmH family group 3 FPL18_RS05135 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FPL18_RS05145 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FPL18_RS05175 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FPL18_RS05210 ENOG4108QCI YvbH-like oligomerisation region FPL18_RS05230 ENOG4105BZ1 (ABC) transporter FPL18_RS05240 ENOG4107ZXU DSBA oxidoreductase FPL18_RS05260 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FPL18_RS05275 ENOG4105D3Y Na H antiporter FPL18_RS05320 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FPL18_RS05325 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FPL18_RS05330 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FPL18_RS05335 ENOG4105PM1 preprotein translocase subunit SecE FPL18_RS05375 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL18_RS05380 ENOG4105TV9 FHA Domain-Containing protein FPL18_RS05385 ENOG4105GVR general secretion pathway protein D FPL18_RS05400 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS FPL18_RS05425 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FPL18_RS05430 ENOG4108NEV two component transcriptional regulator, LytTR family FPL18_RS05435 ENOG4108HRK Histidine kinase FPL18_RS05450 ENOG4108UTW Plays a role in the regulation of phosphate uptake FPL18_RS05465 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FPL18_RS05470 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FPL18_RS05475 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) FPL18_RS05485 ENOG4105CNI cell division protein FtsW FPL18_RS05500 ENOG4105CE1 Ferrous iron transport protein b FPL18_RS05510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL18_RS05515 ENOG4105T95 Thiol disulfide interChange protein FPL18_RS05520 ENOG4105D6E homoserine dehydrogenase FPL18_RS05530 ENOG41061WM D-Alanyl-D-Alanine FPL18_RS05540 ENOG4107TUY Histidine kinase FPL18_RS05545 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL18_RS05550 ENOG4105CN1 protease FPL18_RS05555 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FPL18_RS05560 ENOG4108K5H permease YjgP YjgQ family protein FPL18_RS05565 ENOG4108M8S permease YjgP YjgQ family protein FPL18_RS05590 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FPL18_RS05600 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FPL18_RS05610 ENOG4105BZU Histidine kinase FPL18_RS05625 ENOG4105C0P Mg chelatase subunit ChlI FPL18_RS05650 ENOG4105F0N pyrophosphate phospho-hydrolase FPL18_RS05665 ENOG4105CEY Amp-dependent synthetase and ligase FPL18_RS05670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL18_RS05680 ENOG4105EN6 Membrane FPL18_RS05685 ENOG4105K5B UPF0225 protein FPL18_RS05690 ENOG4105EE5 Membrane protein terC FPL18_RS05700 ENOG4108URH decarboxylase FPL18_RS05710 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL18_RS05720 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL18_RS05725 ENOG4105E3W Two component transcriptional regulator (Winged helix family FPL18_RS05730 ENOG4105EB3 Histidine kinase FPL18_RS05735 ENOG4105CT7 inner membrane cred family protein FPL18_RS05755 ENOG4105CCT upf0313 protein FPL18_RS05765 ENOG4105D94 Major Facilitator Superfamily FPL18_RS05785 ENOG4105CS1 NAD(P)H quinone oxidoreductase FPL18_RS05805 ENOG4105C6T cysteine synthase FPL18_RS05810 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL18_RS05840 ENOG4105C94 Transporter FPL18_RS05860 ENOG4107QN1 sodium solute FPL18_RS05865 ENOG41062QD Membrane FPL18_RS05870 ENOG4105BZU Histidine kinase FPL18_RS05900 ENOG4108WZM domain protein FPL18_RS05905 ENOG4105C79 DNA protecting protein DprA FPL18_RS05920 ENOG4105UIB (ABC) transporter FPL18_RS05925 ENOG4108JQ9 ABC transporter FPL18_RS05970 ENOG4108IND Tetr family transcriptional regulator FPL18_RS05975 ENOG4105F27 Major Facilitator FPL18_RS05980 ENOG4107RTG Major Facilitator superfamily FPL18_RS05990 ENOG4108V06 Glutathione peroxidase FPL18_RS06000 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FPL18_RS06005 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FPL18_RS06015 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FPL18_RS06030 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FPL18_RS06055 ENOG4105FDK ABC transporter FPL18_RS06060 ENOG4105FAV ABC, transporter FPL18_RS06070 ENOG4105EZR dyp-type peroxidase family protein FPL18_RS06095 ENOG4105EUB pirin domain protein FPL18_RS06110 ENOG41090R7 Ferric uptake FPL18_RS06150 ENOG4105C26 Dehydrogenase FPL18_RS06165 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL18_RS06170 ENOG4106MP8 UPF0754 membrane protein FPL18_RS06175 ENOG4105WXI Bacterial OB fold (BOF) protein FPL18_RS06180 ENOG4108VBZ doxx family FPL18_RS06185 ENOG4105DQR SNARE associated Golgi FPL18_RS06200 ENOG4107QJE Chromosome Partitioning Protein FPL18_RS06210 ENOG4107PSF BolA-like protein FPL18_RS06225 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) FPL18_RS06230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS06245 ENOG4105C85 amino acid FPL18_RS06250 ENOG4108594 Permease of the drug metabolite transporter FPL18_RS06255 ENOG4105CSH Transporter FPL18_RS06265 ENOG4105E39 Enoyl-CoA hydratase FPL18_RS06270 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS06280 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL18_RS06285 ENOG4105C26 Dehydrogenase FPL18_RS06295 ENOG4105C85 amino acid FPL18_RS06300 ENOG4105M4H endoribonuclease L-psp FPL18_RS06315 ENOG4105EW9 transcriptional regulator AsnC family FPL18_RS06320 ENOG41084CK capsule polysaccharide FPL18_RS06325 ENOG4105E12 capsule polysaccharide FPL18_RS06370 ENOG4108IJ1 Dehydrogenase FPL18_RS06375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FPL18_RS06380 ENOG4107V1M polysaccharide export protein FPL18_RS06385 ENOG4105ECX polysaccharide export FPL18_RS06395 ENOG41090SZ ABC-2 type transporter FPL18_RS06405 ENOG4108W0I acetyltransferase FPL18_RS06410 ENOG4105D3G Pseudouridine synthase FPL18_RS06465 ENOG4105XMH SpoVT AbrB domain protein FPL18_RS06475 ENOG4108I0Z Aconitate hydratase FPL18_RS06480 ENOG4105BZN citrate synthase FPL18_RS06485 ENOG4105CR4 methylisocitrate lyase FPL18_RS06490 ENOG4105DRR Transcriptional regulator, GntR family FPL18_RS06495 ENOG4105CGF Aromatic amino acid aminotransferase FPL18_RS06500 ENOG4105CXG d-lactate dehydrogenase FPL18_RS06510 ENOG41073TP transcriptional regulator FPL18_RS06515 ENOG4105DAA L-lactate FPL18_RS06520 ENOG4107QKV phosphomannomutase FPL18_RS06525 ENOG4105CMR udp-glucose 4-epimerase FPL18_RS06535 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL18_RS06540 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL18_RS06545 ENOG4105D3Q Sugar transferase FPL18_RS06555 ENOG4105CG5 Glycosyl transferase (Group 1 FPL18_RS06565 ENOG4105CG5 Glycosyl transferase (Group 1 FPL18_RS06580 ENOG4105DAY polysaccharide export protein FPL18_RS06585 ENOG4105D75 Capsular exopolysaccharide family FPL18_RS06590 ENOG4108V1T peptidylprolyl cis-trans isomerase FPL18_RS06595 ENOG4108V1T peptidylprolyl cis-trans isomerase FPL18_RS06605 ENOG4105CJR Integral membrane protein (MviN FPL18_RS06610 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FPL18_RS06615 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FPL18_RS06630 ENOG4105HSS phospholipase C FPL18_RS06655 ENOG41062JF Transcriptional regulator FPL18_RS06670 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL18_RS06675 ENOG4105UBK short-chain dehydrogenase reductase FPL18_RS06685 ENOG4107QZM n-acetylglutamate synthase FPL18_RS06690 ENOG4105GVF (ABC) transporter FPL18_RS06695 ENOG4105GVF (ABC) transporter FPL18_RS06700 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FPL18_RS06705 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL18_RS06710 ENOG4108VM9 ABC, transporter FPL18_RS06715 ENOG4108W9H Tetr family transcriptional regulator FPL18_RS06725 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FPL18_RS06735 ENOG4105DTN riboflavin biosynthesis protein ribF FPL18_RS06740 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FPL18_RS06750 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FPL18_RS06790 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FPL18_RS06820 ENOG4105CFG Acts as a chaperone (By similarity) FPL18_RS06825 ENOG4107T8T UPF0173 metal-dependent hydrolase FPL18_RS06855 ENOG4105CVE Lytic murein transglycosylase FPL18_RS06860 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FPL18_RS06865 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FPL18_RS06880 ENOG4105DFU Cell wall formation (By similarity) FPL18_RS06905 ENOG4105DQS Transcriptional regulator FPL18_RS06915 ENOG4105DU1 integral membrane protein, terc FPL18_RS06925 ENOG4107QUY Guanine deaminase FPL18_RS06930 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL18_RS06940 ENOG4105T95 Thiol disulfide interChange protein FPL18_RS06945 ENOG4105CZX twitching motility protein FPL18_RS06955 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL18_RS06970 ENOG4105VG0 50S ribosomal protein l34 FPL18_RS06980 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL18_RS06990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL18_RS06995 ENOG4105DQR SNARE associated Golgi FPL18_RS07000 ENOG4105C5H ABC transporter FPL18_RS07005 ENOG4108821 RND type efflux pump FPL18_RS07010 ENOG4108821 RND type efflux pump FPL18_RS07015 ENOG4108821 RND type efflux pump FPL18_RS07020 ENOG4108821 RND type efflux pump FPL18_RS07030 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FPL18_RS07035 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FPL18_RS07095 ENOG4105C8J )-transporter FPL18_RS07105 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FPL18_RS07135 ENOG4108KB2 LysR family Transcriptional regulator FPL18_RS07140 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FPL18_RS07155 ENOG4105J7D transcriptional regulator FPL18_RS07160 ENOG4105DJY efflux transporter, rnd family, mfp subunit FPL18_RS07190 ENOG4105F27 Major Facilitator FPL18_RS07195 ENOG4105CV8 reductase FPL18_RS07200 ENOG4105HEI LysR family (Transcriptional regulator FPL18_RS07210 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS07215 ENOG4105DQ4 alcohol dehydrogenase FPL18_RS07220 ENOG4108R3E Dna-3-methyladenine glycosylase i FPL18_RS07235 ENOG4105CEN a g-specific adenine glycosylase FPL18_RS07250 ENOG4108ZZ3 UPF0260 protein FPL18_RS07255 ENOG4105D8V Glucose sorbosone dehydrogenase FPL18_RS07265 ENOG4105D1H recombination factor protein RarA FPL18_RS07285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FPL18_RS07290 ENOG4105C8V SAICAR synthetase FPL18_RS07300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL18_RS07305 ENOG4108RWI nicotinamidase FPL18_RS07350 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FPL18_RS07360 ENOG4108ZAI phosphatidylglycerophosphatase a FPL18_RS07365 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FPL18_RS07370 ENOG4107YIM Involved in the transcription termination process (By similarity) FPL18_RS07380 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FPL18_RS07390 ENOG4105EAC phosphoserine phosphatase FPL18_RS07425 ENOG4105KHC sulfurtransferase FPL18_RS07440 ENOG4105C2C drug resistance transporter, Bcr CflA FPL18_RS07445 ENOG4105CR8 Transcriptional regulator FPL18_RS07450 ENOG4108NIW Leucine export protein LeuE FPL18_RS07455 ENOG4108KB2 LysR family Transcriptional regulator FPL18_RS07460 ENOG4105EJC lysr family transcriptional regulator FPL18_RS07475 ENOG4105BZU Histidine kinase FPL18_RS07480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL18_RS07495 ENOG4107QJQ Mate efflux family protein FPL18_RS07500 ENOG4105CHM Aminotransferase FPL18_RS07505 ENOG4106BRA Membrane FPL18_RS07520 ENOG4105D9M gamma-glutamylcysteine synthetase FPL18_RS07535 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FPL18_RS07565 ENOG4105IPS esterase FPL18_RS07570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL18_RS07575 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein FPL18_RS07580 ENOG4105C32 Amino acid ABC transporter (Permease) FPL18_RS07590 ENOG4105C0Z ABC transporter FPL18_RS07595 ENOG4108IV0 ABC, transporter FPL18_RS07630 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FPL18_RS07655 ENOG4105KUZ arsenate reductase FPL18_RS07660 ENOG4105CGK Exodeoxyribonuclease III FPL18_RS07670 ENOG4105CPF Cell wall formation (By similarity) FPL18_RS07710 ENOG4105K56 Transcriptional regulator FPL18_RS07715 ENOG4108V06 Glutathione peroxidase FPL18_RS07720 ENOG4105D7Z glutathione synthase FPL18_RS07740 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FPL18_RS07745 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FPL18_RS07750 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FPL18_RS07770 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FPL18_RS07775 ENOG4107QSN dihydrolipoamide acetyltransferase FPL18_RS07795 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FPL18_RS07820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FPL18_RS07840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL18_RS07845 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FPL18_RS07855 ENOG4105D64 Mechanosensitive ion channel FPL18_RS07865 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL18_RS07870 ENOG4108W2Y isochorismatase FPL18_RS07880 ENOG4105FBW Monooxygenase FPL18_RS07885 ENOG4108UZX fmn reductase FPL18_RS07900 ENOG4108HWY Beta-lactamase FPL18_RS07915 ENOG4105C85 amino acid FPL18_RS07925 ENOG4108YXU transcriptional regulator AsnC family FPL18_RS07930 ENOG4105BZU Histidine kinase FPL18_RS07935 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FPL18_RS07940 ENOG4108WUH Transcriptional regulator, TetR family FPL18_RS07955 ENOG4105DWF phosphomethylpyrimidine kinase FPL18_RS07965 ENOG4107RDB Major Facilitator FPL18_RS07970 ENOG4108UUM single-stranded DNA-binding protein FPL18_RS07975 ENOG4105CHJ isochorismatase hydrolase FPL18_RS07980 ENOG4105CC0 LysR family Transcriptional regulator FPL18_RS07990 ENOG4105CHJ isochorismatase hydrolase FPL18_RS07995 ENOG4105EUB pirin domain protein FPL18_RS08060 ENOG4105DFH Transport of potassium into the cell (By similarity) FPL18_RS08075 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FPL18_RS08090 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FPL18_RS08115 ENOG4107T8P acyl-Coa dehydrogenase FPL18_RS08135 ENOG4105CHH sulfate transporter FPL18_RS08155 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FPL18_RS08185 ENOG4105CYC Transferase FPL18_RS08190 ENOG4105E0F Histidine kinase FPL18_RS08195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL18_RS08240 ENOG4105CBN LysR family transcriptional regulator FPL18_RS08245 ENOG4105D4T Citrate transporter FPL18_RS08255 ENOG4105CSH Transporter FPL18_RS08260 ENOG4105W1Y Transcriptional regulator FPL18_RS08265 ENOG4107P5I polyketide synthase FPL18_RS08270 ENOG4105PDP Short chain dehydrogenase FPL18_RS08280 ENOG4105C5H ABC transporter FPL18_RS08345 ENOG4108IQI permease FPL18_RS08370 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FPL18_RS08380 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FPL18_RS08385 ENOG4105CJN penicillin-binding protein FPL18_RS08390 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FPL18_RS08395 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FPL18_RS08405 ENOG4105DHI Methyltransferase FPL18_RS08410 ENOG4108JQC penicillin-binding protein 1A FPL18_RS08435 ENOG4105E4G Type IV pilus FPL18_RS08455 ENOG4105CBC glutamate synthase FPL18_RS08460 ENOG4105BZ8 glutamate synthase FPL18_RS08475 ENOG4108V0P LemA family FPL18_RS08480 ENOG4105HA9 of methanol dehydrogenase type FPL18_RS08500 ENOG4105YWY FPL18_RS08505 ENOG4108YSG O-Antigen polymerase FPL18_RS08510 ENOG4108UQY Iron-storage protein FPL18_RS08515 ENOG4105W53 bacterioferritin-associated ferredoxin FPL18_RS08520 ENOG4105KME endoribonuclease L-psp FPL18_RS08525 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL18_RS08535 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FPL18_RS08540 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FPL18_RS08610 ENOG4105K5M 30s ribosomal protein S16 FPL18_RS08615 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FPL18_RS08625 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FPL18_RS08630 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FPL18_RS08645 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase FPL18_RS08650 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) FPL18_RS08665 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase FPL18_RS08670 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FPL18_RS08685 ENOG4108K70 Transcriptional regulator FPL18_RS08695 ENOG4107AQZ Membrane FPL18_RS08700 ENOG4108JQ1 Dehydrogenase FPL18_RS08705 ENOG4105CQB FAD linked oxidase domain protein FPL18_RS08735 ENOG4105VRH Antibiotic biosynthesis monooxygenase FPL18_RS08740 ENOG4105NF4 modulator of drug activity FPL18_RS08755 ENOG4107QF7 multi-drug FPL18_RS08760 ENOG4105EM2 membrane FPL18_RS08765 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL18_RS08770 ENOG4105IPI Membrane FPL18_RS08775 ENOG4107SKI cobyrinic Acid a,c-diamide synthase FPL18_RS08785 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL18_RS08820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL18_RS08860 ENOG4105C8P )-transporter FPL18_RS08875 ENOG4105W87 Cbs domain FPL18_RS08880 ENOG41067S9 phage shock protein C, PspC FPL18_RS08890 ENOG4105CSU acyl-Coa dehydrogenase FPL18_RS08915 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) FPL18_RS08930 ENOG4105ECY inositol monophosphatase FPL18_RS08940 ENOG4105C1J atp-dependent rna helicase FPL18_RS08945 ENOG4105DHJ ABC, transporter FPL18_RS08950 ENOG4105CY3 ABC transporter, permease FPL18_RS08955 ENOG4107PE3 Mammalian cell entry related domain protein FPL18_RS08960 ENOG4105E3I toluene tolerance FPL18_RS08980 ENOG4108URH decarboxylase FPL18_RS08990 ENOG4105MJ2 Competence protein FPL18_RS08995 ENOG4105CB5 ATP-dependent DNA helicase recG FPL18_RS09010 ENOG4105E55 glycerol-3-phosphate acyltransferase FPL18_RS09015 ENOG4105C29 acyl-CoA thioesterase FPL18_RS09020 ENOG4105CK2 sodium dicarboxylate symporter FPL18_RS09040 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FPL18_RS09045 ENOG4105D7A ATP-binding protein FPL18_RS09055 ENOG41089BK Glutamine amido-transferase FPL18_RS09065 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FPL18_RS09085 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FPL18_RS09110 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FPL18_RS09135 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FPL18_RS09150 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FPL18_RS09165 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FPL18_RS09170 ENOG41067V7 50S ribosomal protein L36 FPL18_RS09180 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FPL18_RS09185 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FPL18_RS09195 ENOG4108ZT0 50S ribosomal protein l17 FPL18_RS09215 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS09260 ENOG4105EMK carboxylate amino acid amine transporter FPL18_RS09265 ENOG4108W3Q Transcriptional regulator FPL18_RS09285 ENOG4105DGW oligopeptidase A FPL18_RS09295 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FPL18_RS09320 ENOG4108KK1 membrane protein AbrB duplication FPL18_RS09370 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FPL18_RS09385 ENOG4107S2Z UPF0761 membrane protein FPL18_RS09390 ENOG4105CS1 NAD(P)H quinone oxidoreductase FPL18_RS09410 ENOG4105G6Z alkaline phosphatase FPL18_RS09465 ENOG4105DWV Homoserine O-trans-acetylase FPL18_RS09475 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FPL18_RS09485 ENOG4108ESX Receptor FPL18_RS09490 ENOG4105D05 Receptor FPL18_RS09500 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FPL18_RS09530 ENOG4107GFK fumarate FPL18_RS09540 ENOG4105DWP Membrane FPL18_RS09550 ENOG4108DNC Involved in acetate metabolism (By similarity) FPL18_RS09555 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FPL18_RS09565 ENOG4106HB6 Alpha beta hydrolase FPL18_RS09590 ENOG4105EJC lysr family transcriptional regulator FPL18_RS09620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL18_RS09630 ENOG4107RZC phospholipase d FPL18_RS09640 ENOG4105UYK outer membrane protein a FPL18_RS09645 ENOG4108KHX Diguanylate cyclase FPL18_RS09695 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS09710 ENOG4105KNA -acetyltransferase FPL18_RS09715 ENOG4108RZE Tetr family transcriptional regulator FPL18_RS09730 ENOG4107QX3 carboxylase FPL18_RS09735 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS09785 ENOG4105KB2 stringent starvation protein b FPL18_RS09790 ENOG4107MKT Stringent starvation protein a FPL18_RS09800 ENOG4108UJD 30S ribosomal protein S9 FPL18_RS09805 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FPL18_RS09820 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FPL18_RS09825 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FPL18_RS09830 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FPL18_RS09845 ENOG4105WVQ Fe-S assembly protein IscX FPL18_RS09885 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FPL18_RS09905 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FPL18_RS09925 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FPL18_RS09935 ENOG4105C84 Histidine ammonia-lyase FPL18_RS09955 ENOG4107T3I fad-binding protein FPL18_RS09965 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FPL18_RS09975 ENOG4105C2D reductase FPL18_RS09980 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FPL18_RS09995 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FPL18_RS10000 ENOG410633P Hydantoin racemase FPL18_RS10005 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL18_RS10010 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL18_RS10015 ENOG4105VIE preprotein translocase, subunit YajC FPL18_RS10050 ENOG4105BZU Histidine kinase FPL18_RS10055 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FPL18_RS10060 ENOG4105CM2 brancheD-chain amino acid aminotransferase FPL18_RS10075 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL18_RS10115 ENOG4107J0A lipopolysaccharide biosynthetic process FPL18_RS10120 ENOG4107J0A lipopolysaccharide biosynthetic process FPL18_RS10125 ENOG4107J0A lipopolysaccharide biosynthetic process FPL18_RS10140 ENOG4105C9M aspartyl-trna synthetase FPL18_RS10155 ENOG4105UGU tonB-dependent Receptor FPL18_RS10195 ENOG4105EQ2 LysR family Transcriptional regulator FPL18_RS10200 ENOG4105CSU acyl-Coa dehydrogenase FPL18_RS10205 ENOG4105CSU acyl-Coa dehydrogenase FPL18_RS10215 ENOG4105EB3 Histidine kinase FPL18_RS10220 ENOG4105E3W Two component transcriptional regulator (Winged helix family FPL18_RS10240 ENOG4105CNG UPF0061 protein FPL18_RS10260 ENOG4108WBT adenosyltransferase FPL18_RS10275 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FPL18_RS10285 ENOG4107T31 5'-nucleotidase FPL18_RS10325 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FPL18_RS10345 ENOG4105D3R alkyl hydroperoxide reductase FPL18_RS10365 ENOG4105CSH Transporter FPL18_RS10370 ENOG4108UT2 hemolysin iii FPL18_RS10405 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS10425 ENOG4108R6W Transcriptional regulator, ARAC family FPL18_RS10430 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FPL18_RS10435 ENOG4105TW1 Carbohydrate-selective porin OprB FPL18_RS10440 ENOG4105DZG Dehydrogenase FPL18_RS10445 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FPL18_RS10460 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS10470 ENOG4108WHA ompa motb domain protein FPL18_RS10475 ENOG4108WHA ompa motb domain protein FPL18_RS10480 ENOG4105E0Y RtcB Protein FPL18_RS10485 ENOG4108IQI permease FPL18_RS10495 ENOG4105C2W permease FPL18_RS10515 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FPL18_RS10525 ENOG4105CHB tonB-dependent Receptor FPL18_RS10535 ENOG4105T95 Thiol disulfide interChange protein FPL18_RS10550 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) FPL18_RS10565 ENOG4105K78 MarR family Transcriptional regulator FPL18_RS10570 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FPL18_RS10575 ENOG4105KWI UPF0339 protein FPL18_RS10590 ENOG4108UNF response regulator FPL18_RS10595 ENOG4105M3Z response regulator FPL18_RS10600 ENOG4108ZGA chew protein FPL18_RS10605 ENOG4105C8Q Methyl-accepting chemotaxis FPL18_RS10610 ENOG4105CBS Chea signal transduction histidine kinase FPL18_RS10620 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) FPL18_RS10625 ENOG4106HKS Entericidin EcnA/B family FPL18_RS10635 ENOG4105WD1 Membrane FPL18_RS10640 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FPL18_RS10685 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FPL18_RS10720 ENOG4105EM2 membrane FPL18_RS10725 ENOG4105C2C drug resistance transporter, Bcr CflA FPL18_RS10740 ENOG4105D6U Sodium Glutamate Symporter FPL18_RS10745 ENOG4105BZG amino acid carrier protein FPL18_RS10750 ENOG4105D78 K07001 NTE family protein FPL18_RS10760 ENOG4105C9K Endothelin-converting enzyme 1 FPL18_RS10820 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FPL18_RS10830 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FPL18_RS10835 ENOG4105DFF Rod shape-determining protein mreb FPL18_RS10840 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FPL18_RS10850 ENOG4108Z03 MAF-like protein FPL18_RS10855 ENOG4105C03 ribonuclease FPL18_RS10865 ENOG4105D8T Acyltransferase FPL18_RS10875 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein FPL18_RS10890 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FPL18_RS10895 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FPL18_RS10900 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FPL18_RS10905 ENOG4105C08 Histidine kinase FPL18_RS10910 ENOG4105EEX Two component transcriptional regulator (Winged helix family FPL18_RS10915 ENOG4106B0W Curli production assembly transport component CsgG FPL18_RS10925 ENOG4107Y60 (LipO)protein FPL18_RS10930 ENOG4107RGH Aldehyde dehydrogenase FPL18_RS10935 ENOG4108R6W Transcriptional regulator, ARAC family FPL18_RS10940 ENOG4105D4T Citrate transporter FPL18_RS10950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FPL18_RS10955 ENOG4105CFQ glutamine synthetase FPL18_RS10965 ENOG4105C85 amino acid FPL18_RS10970 ENOG4105C7F AcnD-accessory protein PrpF FPL18_RS10975 ENOG4105CTB Polyprenyl synthetase FPL18_RS10980 ENOG4105MSB protein, conserved in bacteria FPL18_RS10995 ENOG4105D78 K07001 NTE family protein FPL18_RS11015 ENOG4105DIJ Phosphoethanolamine transferase FPL18_RS11020 ENOG4105XJC Two component transcriptional regulator (Winged helix family FPL18_RS11025 ENOG4105DHQ Histidine kinase FPL18_RS11040 ENOG4105CDA abc transporter atp-binding protein FPL18_RS11045 ENOG4105DRP amino acid AbC transporter FPL18_RS11050 ENOG4105EAD ABC transporter FPL18_RS11055 ENOG4107RP9 extracellular solute-binding protein, family 3 FPL18_RS11065 ENOG4105CRW Short chain fatty acid transporter FPL18_RS11080 ENOG4108M0I Transcriptional regulator FPL18_RS11085 ENOG4105CY2 Citrate transporter FPL18_RS11090 ENOG4105DTD Dehydrogenase FPL18_RS11110 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FPL18_RS11115 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FPL18_RS11140 ENOG4105K8R UPF0145 protein FPL18_RS11145 ENOG4105K8R UPF0145 protein FPL18_RS11150 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL18_RS11155 ENOG4105BZS acriflavin resistance protein FPL18_RS11160 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL18_RS11165 ENOG410841Q phosphoesterase PA-phosphatase related protein FPL18_RS11190 ENOG4105EUB pirin domain protein FPL18_RS11195 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) FPL18_RS11210 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL18_RS11215 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FPL18_RS11225 ENOG4105KVH Transcriptional regulator FPL18_RS11245 ENOG4105CUB amino acid FPL18_RS11250 ENOG4105C0A alcohol dehydrogenase FPL18_RS11260 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) FPL18_RS11265 ENOG4108Z43 UPF0250 protein FPL18_RS11270 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL18_RS11285 ENOG4105N14 lysine exporter protein LysE YggA FPL18_RS11295 ENOG4107T5V SNARE associated Golgi FPL18_RS11300 ENOG4105C72 UPF0176 protein FPL18_RS11320 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FPL18_RS11325 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FPL18_RS11335 ENOG4105E33 succinate dehydrogenase FPL18_RS11345 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FPL18_RS11350 ENOG4105C7S Dehydrogenase FPL18_RS11355 ENOG4107QN2 dihydrolipoyl dehydrogenase FPL18_RS11365 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FPL18_RS11375 ENOG4107S78 Band 7 protein FPL18_RS11380 ENOG4105PV3 Inner membrane protein yqiJ FPL18_RS11390 ENOG4105CKW Inner membrane protein yedI FPL18_RS11395 ENOG4105CGZ zinc metallopeptidase FPL18_RS11400 ENOG4105EEQ Na H antiporter FPL18_RS11415 ENOG4105PNM synthesis protein FPL18_RS11430 ENOG4107YZX Universal stress protein FPL18_RS11435 ENOG4105EQK -acetyltransferase FPL18_RS11450 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FPL18_RS11455 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FPL18_RS11470 ENOG4105HBR Rna-binding protein FPL18_RS11480 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FPL18_RS11495 ENOG4105CP2 von willebrand factor, type a FPL18_RS11500 ENOG4105C7B Threonine dehydratase FPL18_RS11510 ENOG4107U2T alpha beta FPL18_RS11515 ENOG4108Q5Y Membrane FPL18_RS11520 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FPL18_RS11525 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FPL18_RS11530 ENOG4105DIJ Phosphoethanolamine transferase FPL18_RS11535 ENOG4105BZS acriflavin resistance protein FPL18_RS11540 ENOG4105CJW magnesium transporter FPL18_RS11550 ENOG4105D0M Protease HtpX homolog FPL18_RS11555 ENOG4105E4C Lytic transglycosylase catalytic FPL18_RS11575 ENOG4108RRZ Transcription elongation factor GreB FPL18_RS11590 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FPL18_RS11630 ENOG4105CKI cobalamin synthesis protein FPL18_RS11635 ENOG4108VWS Yaeq family FPL18_RS11650 ENOG4107BJW polysaccharide deacetylase FPL18_RS11655 ENOG4105CND Glycosyl transferase, family 2 FPL18_RS11695 ENOG410830R acetyltransferase FPL18_RS11705 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FPL18_RS11710 ENOG4105E98 transcriptional regulator DeoR family FPL18_RS11715 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FPL18_RS11735 ENOG4105CBD Diacylglycerol kinase FPL18_RS11760 ENOG41080IJ Diacylglycerol kinase FPL18_RS11770 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FPL18_RS11780 ENOG4105E6M Sulphatase-modifying factor protein FPL18_RS11785 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) FPL18_RS11800 ENOG4105D05 Receptor FPL18_RS11815 ENOG4108V9Q carbonic anhydrase FPL18_RS11825 ENOG4108UJV acyl-CoA thioesterase i FPL18_RS11830 ENOG4108I0Y (ABC) transporter FPL18_RS11835 ENOG4105CV6 ABC transporter, permease FPL18_RS11840 ENOG4107ZXI Rhomboid family FPL18_RS11880 ENOG4107R8N Glycosyl transferase, family 2 FPL18_RS11895 ENOG4105CVP deoxyribo-dipyrimidine photolyase FPL18_RS11900 ENOG4108YZY peptidylprolyl cis-trans isomerase FPL18_RS11905 ENOG4105CEP NADH dehydrogenase FPL18_RS11910 ENOG4105DZ1 carboxypeptidase FPL18_RS11920 ENOG4105VT2 5-hydroxyisourate hydrolase FPL18_RS11940 ENOG4105E9K Isocitrate dehydrogenase FPL18_RS11945 ENOG4108R99 pseudouridine synthase FPL18_RS11970 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL18_RS11990 ENOG4105I7R Adenylate cyclase FPL18_RS12005 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FPL18_RS12020 ENOG4105D3G Pseudouridine synthase FPL18_RS12025 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FPL18_RS12030 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction FPL18_RS12040 ENOG4105EJ2 Transcriptional regulator FPL18_RS12070 ENOG4105GAV receptor FPL18_RS12075 ENOG4105GAV receptor FPL18_RS12085 ENOG4108JPW Aminotransferase FPL18_RS12090 ENOG4105DY8 decarboxylase FPL18_RS12100 ENOG4105C26 Dehydrogenase FPL18_RS12105 ENOG4105F7P transcriptional regulator AsnC family FPL18_RS12110 ENOG4107RA9 decarboxylase FPL18_RS12115 ENOG4105C85 amino acid FPL18_RS12125 ENOG4105CVA phosphate FPL18_RS12130 ENOG4105C8U phosphate abc transporter FPL18_RS12140 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FPL18_RS12145 ENOG4105ERU peptidase FPL18_RS12170 ENOG4106H78 methyltransferase FPL18_RS12175 ENOG4105CJN penicillin-binding protein FPL18_RS12200 ENOG4105CSM endonuclease III FPL18_RS12205 ENOG4108R3D Electron transport complex FPL18_RS12210 ENOG4105D82 Glutamate dehydrogenase FPL18_RS12220 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FPL18_RS12235 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FPL18_RS12245 ENOG4105UYK outer membrane protein a FPL18_RS12265 ENOG4108821 RND type efflux pump FPL18_RS12305 ENOG4107RAQ aminopeptidase FPL18_RS12310 ENOG4105D0A hydroxylase FPL18_RS12315 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FPL18_RS12335 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FPL18_RS12350 ENOG4105W4M Transport-associated protein FPL18_RS12360 ENOG4105E09 nadh pyrophosphatase FPL18_RS12370 ENOG4107RZZ dna polymerase iii epsilon subunit FPL18_RS12375 ENOG4105E9H Lytic Murein transglycosylase FPL18_RS12380 ENOG4105E43 Extracellular solute-binding protein, family 5 FPL18_RS12385 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FPL18_RS12390 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FPL18_RS12395 ENOG4108JQ5 ABC transporter FPL18_RS12410 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FPL18_RS12435 ENOG4105NX3 Membrane FPL18_RS12460 ENOG4105EUJ GTP cyclohydrolase i FPL18_RS12485 ENOG4105D05 Receptor FPL18_RS12495 ENOG4108ETY sodium dicarboxylate symporter FPL18_RS12500 ENOG4105DDQ anthranilate synthase FPL18_RS12505 ENOG4105C5F glutamine synthetase FPL18_RS12520 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) FPL18_RS12585 ENOG4106TD9 Diguanylate cyclase FPL18_RS12590 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FPL18_RS12640 ENOG4107QS8 (LipO)protein FPL18_RS12645 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL18_RS12650 ENOG4105C5Q Transcriptional regulator FPL18_RS12655 ENOG4105DWV Homoserine O-trans-acetylase FPL18_RS12660 ENOG4107QZF nitrite reductase NADPH large subunit FPL18_RS12665 ENOG4105VCQ rubredoxin FPL18_RS12675 ENOG4105CRK lysyL-tRNA synthetase FPL18_RS12680 ENOG4108MRJ FPL18_RS12685 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FPL18_RS12690 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) FPL18_RS12710 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FPL18_RS12715 ENOG4105C37 (CBS) domain FPL18_RS12725 ENOG4107RET Isocitrate lyase FPL18_RS12730 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL18_RS12735 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL18_RS12740 ENOG4107QNR UPF0135 protein FPL18_RS12745 ENOG4105C0H protease FPL18_RS12765 ENOG4107RNU major facilitator superfamily MFS_1 FPL18_RS12775 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL18_RS12780 ENOG4105CE9 30S ribosomal protein S2 FPL18_RS12790 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FPL18_RS12825 ENOG4105ETS cytosine purines uracil thiamine allantoin FPL18_RS12835 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FPL18_RS12845 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FPL18_RS12850 ENOG4108IUZ ABC transporter FPL18_RS12855 ENOG4105DFG type I secretion outer membrane protein FPL18_RS12885 ENOG4108VQJ O-methyltransferase FPL18_RS12895 ENOG4108Z4U Ferredoxin FPL18_RS12915 ENOG4108MP6 LysR family Transcriptional regulator FPL18_RS12920 ENOG4105C5A transporter FPL18_RS12940 ENOG4108JIK carboxylase FPL18_RS12950 ENOG4105CND Glycosyl transferase, family 2 FPL18_RS12975 ENOG4105X58 receptor FPL18_RS12985 ENOG4105CR8 Transcriptional regulator FPL18_RS12995 ENOG4105F04 LysR family Transcriptional regulator FPL18_RS13020 ENOG4105KT5 UmuD protein FPL18_RS13030 ENOG4105CC0 LysR family Transcriptional regulator FPL18_RS13055 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FPL18_RS13060 ENOG4105ERG peptidase m48, ste24p FPL18_RS13075 ENOG4105KTH gatB Yqey FPL18_RS13080 ENOG4105VCC 30S ribosomal protein S21 FPL18_RS13100 ENOG4108UZ3 Transporter FPL18_RS13135 ENOG4105D9P serine threonine protein kinase FPL18_RS13175 ENOG4105C0A alcohol dehydrogenase FPL18_RS13180 ENOG4108JUB Transcriptional regulator FPL18_RS13205 ENOG4105C85 amino acid FPL18_RS13210 ENOG4105CS6 Rhs element vgr protein FPL18_RS13245 ENOG4107QTF adenylosuccinate lyase FPL18_RS13255 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FPL18_RS13275 ENOG4108Z0R Transferase FPL18_RS13280 ENOG4105DZ1 carboxypeptidase FPL18_RS13305 ENOG4108K5P (LipO)protein FPL18_RS13310 ENOG4105EJC lysr family transcriptional regulator FPL18_RS13315 ENOG4105DAN ATP-dependent protease FPL18_RS13330 ENOG4105DHU Bile acid FPL18_RS13350 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FPL18_RS13355 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FPL18_RS13360 ENOG4105D22 carbon starvation protein FPL18_RS13365 ENOG4105VCD cytoplasmic protein FPL18_RS13370 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL18_RS13380 ENOG4105F8C transglutaminase domain-containing protein FPL18_RS13395 ENOG4105C2I pirin domain protein FPL18_RS13405 ENOG4105EGI Transcriptional regulator FPL18_RS13410 ENOG4108Q5Y Membrane FPL18_RS13415 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL18_RS13435 ENOG4105DIJ Phosphoethanolamine transferase FPL18_RS13450 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FPL18_RS13455 ENOG4105C85 amino acid FPL18_RS13460 ENOG4105D5K Hemolysin activator protein FPL18_RS13465 ENOG4105CKT filamentous hemagglutinin FPL18_RS13475 ENOG4105EAD ABC transporter FPL18_RS13490 ENOG4107RP9 extracellular solute-binding protein, family 3 FPL18_RS13535 ENOG4105EU0 Major facilitator Superfamily FPL18_RS13540 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FPL18_RS13545 ENOG4105T0Z Conserved Protein FPL18_RS13550 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS13560 ENOG4105CR8 Transcriptional regulator FPL18_RS13575 ENOG4105E39 Enoyl-CoA hydratase FPL18_RS13580 ENOG4107QX3 carboxylase FPL18_RS13585 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS13590 ENOG4105R8C Transcriptional regulator FPL18_RS13595 ENOG4105CEY Amp-dependent synthetase and ligase FPL18_RS13615 ENOG4105D2S major facilitator superfamily FPL18_RS13620 ENOG4105EVZ LysR family transcriptional regulator FPL18_RS13625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL18_RS13630 ENOG4105C26 Dehydrogenase FPL18_RS13640 ENOG4107AQZ Membrane FPL18_RS13655 ENOG4108JPW Aminotransferase FPL18_RS13660 ENOG4105C26 Dehydrogenase FPL18_RS13675 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FPL18_RS13685 ENOG4105C26 Dehydrogenase FPL18_RS13690 ENOG4105CUB amino acid FPL18_RS13695 ENOG4105DWY Agmatine deiminase FPL18_RS13700 ENOG4105KPY Small multidrug resistance protein FPL18_RS13705 ENOG4105KPY Small multidrug resistance protein FPL18_RS13725 ENOG4105PDP Short chain dehydrogenase FPL18_RS13730 ENOG41069M3 Transcriptional regulator FPL18_RS13760 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase FPL18_RS13765 ENOG4105DJB Major Facilitator Superfamily FPL18_RS13780 ENOG4105CHR reductase FPL18_RS13795 ENOG4105C7K acetolactate synthase FPL18_RS13810 ENOG4105F95 Monooxygenase FPL18_RS13825 ENOG4105EMY transcriptional regulator FPL18_RS13835 ENOG4107Y2X deaminase FPL18_RS13840 ENOG4105DJ2 Major Facilitator Superfamily FPL18_RS13880 ENOG4105CD8 aminopeptidase N FPL18_RS13890 ENOG4105VK3 rdd domain containing protein FPL18_RS13905 ENOG4105CKD glutathione-regulated potassium-efflux system protein FPL18_RS13910 ENOG4105DKK Benzoate FPL18_RS13915 ENOG4108NIW Leucine export protein LeuE FPL18_RS13920 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL18_RS13925 ENOG4105DUM transcriptional regulator, lysR family FPL18_RS13945 ENOG4108JA2 transcriptioN-repair coupling factor FPL18_RS13955 ENOG4105F8J Adenylate Guanylate cyclase FPL18_RS13960 ENOG4108Z40 Transcriptional regulator FPL18_RS13970 ENOG4108ZIT Ferredoxin, 2FE-2S FPL18_RS13985 ENOG4108Z4V iron-sulfur cluster assembly FPL18_RS13990 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FPL18_RS14000 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family FPL18_RS14015 ENOG4105K70 DNA-binding protein FPL18_RS14020 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL18_RS14035 ENOG4105Y3E Modulates RecA activity (By similarity) FPL18_RS14045 ENOG4105VEJ Heat shock protein FPL18_RS14050 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FPL18_RS14055 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FPL18_RS14080 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) FPL18_RS14085 ENOG4105K4T epimerase FPL18_RS14090 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) FPL18_RS14110 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS14115 ENOG4105CHR reductase FPL18_RS14145 ENOG4108UHJ MAF-like protein FPL18_RS14170 ENOG41069NU Nitroreductase FPL18_RS14205 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FPL18_RS14255 ENOG4108JU3 Alkyl hydroperoxide reductase FPL18_RS14270 ENOG4105D7W serine acetyltransferase FPL18_RS14280 ENOG4105C0B DNA polymerase III (alpha subunit) FPL18_RS14290 ENOG4105CHM Aminotransferase FPL18_RS14300 ENOG4108V06 Glutathione peroxidase FPL18_RS14325 ENOG4105J0Q Transcriptional regulator FPL18_RS14365 ENOG4105IJJ transcriptional regulator, crp fnr family FPL18_RS14375 ENOG4105CS6 Rhs element vgr protein FPL18_RS14410 ENOG4105C3G gtp-binding protein FPL18_RS14415 ENOG4108UMI ABC transporter, permease FPL18_RS14420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FPL18_RS14425 ENOG4105D01 (LipO)protein FPL18_RS14440 ENOG4107T8P acyl-Coa dehydrogenase FPL18_RS14505 ENOG4105X0I Fimbrial FPL18_RS14525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FPL18_RS14530 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FPL18_RS14560 ENOG4105VEQ Cold shock protein FPL18_RS14565 ENOG4105VEQ Cold shock protein FPL18_RS14570 ENOG4105CJP fad dependent oxidoreductase FPL18_RS14580 ENOG4105UCG Domain of unknown function (DUF333) FPL18_RS14600 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FPL18_RS14605 ENOG4105CV1 Transketolase (EC 2.2.1.1) FPL18_RS14625 ENOG4108YYC ycei family FPL18_RS14630 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FPL18_RS14660 ENOG41080VW acetyltransferase FPL18_RS14685 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) FPL18_RS14690 ENOG4105YGK Pfam:UPF0157 FPL18_RS14695 ENOG4105C26 Dehydrogenase FPL18_RS14700 ENOG4105EW9 transcriptional regulator AsnC family FPL18_RS14705 ENOG4105CK7 Sodium proline symporter FPL18_RS14710 ENOG4108IJ0 Aspartate ammonia-lyase FPL18_RS14715 ENOG4108M1A Chitin-binding protein FPL18_RS14725 ENOG4108ZX5 transcriptional regulator FPL18_RS14735 ENOG4105BZ1 (ABC) transporter FPL18_RS14810 ENOG4105CUY Mechanosensitive ion channel FPL18_RS14815 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FPL18_RS14835 ENOG41080HT Transcriptional regulator, arsr family FPL18_RS14855 ENOG4105EZE Cupin 4 family protein FPL18_RS14860 ENOG4107QMP dna polymerase iii subunits gamma and tau FPL18_RS14865 ENOG4108M24 von Willebrand factor, type A FPL18_RS14910 ENOG4105DAX Pfam:DUF2983 FPL18_RS14960 ENOG4105C0A alcohol dehydrogenase FPL18_RS14985 ENOG4105CBC glutamate synthase FPL18_RS14995 ENOG4105C26 Dehydrogenase FPL18_RS15000 ENOG4105C0A alcohol dehydrogenase FPL18_RS15005 ENOG4105CY2 Citrate transporter FPL18_RS15030 ENOG4108RXX maleylacetoacetate isomerase FPL18_RS15040 ENOG4105C85 amino acid FPL18_RS15045 ENOG4105ETT transcriptional Regulator, LysR family FPL18_RS15055 ENOG4105DVW rieske (2Fe-2S) FPL18_RS15060 ENOG4105C26 Dehydrogenase FPL18_RS15065 ENOG4107QZF nitrite reductase NADPH large subunit FPL18_RS15090 ENOG4105D8G Major Facilitator superfamily FPL18_RS15105 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL18_RS15110 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FPL18_RS15130 ENOG4107RNU major facilitator superfamily MFS_1 FPL18_RS15135 ENOG4107QZF nitrite reductase NADPH large subunit FPL18_RS15140 ENOG4108IFG nitrite reductase, (NAD(P)H) FPL18_RS15155 ENOG4105CBP Major Facilitator FPL18_RS15160 ENOG4105EGI Transcriptional regulator FPL18_RS15165 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FPL18_RS15170 ENOG4105E2B Taurine dioxygenase FPL18_RS15180 ENOG4105F27 Major Facilitator FPL18_RS15195 ENOG4105HMI Membrane FPL18_RS15265 ENOG4107VMU Membrane FPL18_RS15280 ENOG4105CEV competence damage-inducible protein FPL18_RS15300 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FPL18_RS15340 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FPL18_RS15345 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL18_RS15355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS15360 ENOG4105T38 integral membrane protein FPL18_RS15365 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FPL18_RS15380 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FPL18_RS15410 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FPL18_RS15430 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL18_RS15435 ENOG4105CUX Signal transduction histidine kinase FPL18_RS15450 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FPL18_RS15460 ENOG4105KNE Phosphatidate cytidylyltransferase FPL18_RS15470 ENOG4105DZP Membrane-associated zinc metalloprotease FPL18_RS15475 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FPL18_RS15485 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL18_RS15495 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL18_RS15500 ENOG4105E7U AraC family transcriptional regulator FPL18_RS15505 ENOG4105EEF Alkane 1-monooxygenase FPL18_RS15510 ENOG4105DC8 reductase FPL18_RS15515 ENOG4105DHQ Histidine kinase FPL18_RS15525 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FPL18_RS15530 ENOG4107QX9 Thiol disulfide interChange protein FPL18_RS15535 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FPL18_RS15540 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS15545 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS15555 ENOG4105DNH Major Facilitator FPL18_RS15565 ENOG4105DXM phenylacetic acid degradation protein FPL18_RS15570 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FPL18_RS15575 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FPL18_RS15580 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FPL18_RS15585 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FPL18_RS15590 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FPL18_RS15595 ENOG4105E39 Enoyl-CoA hydratase FPL18_RS15600 ENOG4108UKI Enoyl-CoA hydratase FPL18_RS15605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FPL18_RS15610 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS15615 ENOG4105DZS Phenylacetate-CoA ligase FPL18_RS15620 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FPL18_RS15625 ENOG4108Z0R Transferase FPL18_RS15630 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FPL18_RS15650 ENOG4107HP6 Transcriptional regulator FPL18_RS15655 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase FPL18_RS15675 ENOG4108Z66 YbaK ebsC protein FPL18_RS15705 ENOG4105EYM Major Facilitator superfamily FPL18_RS15720 ENOG4107VXZ Hydrolase FPL18_RS15730 ENOG4108YZT Adenosylcobinamide kinase FPL18_RS15735 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) FPL18_RS15740 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FPL18_RS15760 ENOG4105D05 Receptor FPL18_RS15780 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FPL18_RS15785 ENOG4107TSN permease FPL18_RS15815 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FPL18_RS15845 ENOG4105CYW agmatinase FPL18_RS15850 ENOG4105EVZ LysR family transcriptional regulator FPL18_RS15860 ENOG4105K59 histidine triad (HIT) protein FPL18_RS15935 ENOG4105C28 cystathionine FPL18_RS15945 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FPL18_RS15975 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FPL18_RS15980 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FPL18_RS15990 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria FPL18_RS16000 ENOG4105HSS phospholipase C FPL18_RS16005 ENOG4108X0B nad(p)h dehydrogenase (quinone) FPL18_RS16010 ENOG4108R6W Transcriptional regulator, ARAC family FPL18_RS16015 ENOG4108HPI phosphatidate Cytidylyltransferase FPL18_RS16030 ENOG41077RS Phosphatase FPL18_RS16035 ENOG4105E8V Alpha Beta Hydrolase Fold protein FPL18_RS16040 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FPL18_RS16115 ENOG4108YUH FPL18_RS16135 ENOG4105VYA Uncharacterized conserved protein (DUF2132) FPL18_RS16145 ENOG4105CHR reductase FPL18_RS16150 ENOG4105ETT transcriptional Regulator, LysR family FPL18_RS16155 ENOG4107Z3H Transcriptional regulator, TetR family FPL18_RS16200 ENOG4105CPN adenine deaminase FPL18_RS16210 ENOG4105E0K tonB-dependent siderophore receptor FPL18_RS16215 ENOG4105CKI cobalamin synthesis protein FPL18_RS16230 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FPL18_RS16235 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FPL18_RS16245 ENOG4105CD3 dihydroorotase FPL18_RS16260 ENOG4108YNN Heme oxygenase FPL18_RS16270 ENOG4108SF5 RNA Polymerase FPL18_RS16275 ENOG41067MG lrgb family FPL18_RS16280 ENOG4105VAW lrga family FPL18_RS16285 ENOG4105CMU LysR family (Transcriptional regulator FPL18_RS16290 ENOG4105CYM Glutathione S-transferase FPL18_RS16295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS16300 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FPL18_RS16325 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL18_RS16330 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL18_RS16340 ENOG4108SC4 )-transporter FPL18_RS16360 ENOG4108YNN Heme oxygenase FPL18_RS16370 ENOG4108R0G Tetratricopeptide repeat protein FPL18_RS16390 ENOG4108SF5 RNA Polymerase FPL18_RS16400 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FPL18_RS16410 ENOG4107SWG transcriptional regulator MERR family FPL18_RS16425 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL18_RS16440 ENOG4105EG6 Saccharopine dehydrogenase FPL18_RS16445 ENOG4108JA1 polyketide synthase FPL18_RS16475 ENOG4105ETX regulatoR FPL18_RS16480 ENOG4105DHQ Histidine kinase FPL18_RS16495 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FPL18_RS16520 ENOG4108WQI RNA Polymerase FPL18_RS16530 ENOG4105E18 UPF0276 protein FPL18_RS16545 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL18_RS16550 ENOG4105GR3 Histidine kinase FPL18_RS16565 ENOG4108UAJ Transcriptional regulator FPL18_RS16585 ENOG4108ZIT Ferredoxin, 2FE-2S FPL18_RS16595 ENOG4105DDY UPF0142 protein ycaO FPL18_RS16605 ENOG4108IPJ Membrane FPL18_RS16675 ENOG4105CF7 AraC family transcriptional regulator FPL18_RS16680 ENOG4105DRR Transcriptional regulator, GntR family FPL18_RS16695 ENOG4105F4R Transcriptional regulator mode FPL18_RS16710 ENOG4107RZC phospholipase d FPL18_RS16835 ENOG4105XB7 anti-repressor protein FPL18_RS16920 ENOG4107ZQ5 Phage-associated protein, HI1409 family FPL18_RS16925 ENOG4108N0N Phage Terminase Large Subunit FPL18_RS17095 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FPL18_RS17145 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FPL18_RS17150 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FPL18_RS17185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL18_RS17195 ENOG4108MXF Alpha Beta Hydrolase FPL18_RS17200 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FPL18_RS17205 ENOG4105C5H ABC transporter FPL18_RS17215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL18_RS17220 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FPL18_RS17225 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) FPL18_RS17260 ENOG4105C7B Threonine dehydratase FPL18_RS17270 ENOG4105CZN Potassium uptake protein FPL18_RS17280 ENOG4105HDD phospholipase FPL18_RS17315 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL18_RS17320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL18_RS17375 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FPL18_RS17400 ENOG4105C2X Arabinose 5-phosphate isomerase FPL18_RS17405 ENOG4105C8Y Acetylornithine aminotransferase FPL18_RS17410 ENOG4105M2J Glutaredoxin FPL18_RS17420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL18_RS17425 ENOG4105CC0 LysR family Transcriptional regulator FPL18_RS17430 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL18_RS17435 ENOG4105CWM branched-chain amino acid transport system II carrier protein FPL18_RS17470 ENOG4107QP3 malate synthase g FPL18_RS17475 ENOG4105D6Z AFG1 family ATPase FPL18_RS17485 ENOG4107RN6 Monooxygenase FPL18_RS17490 ENOG4105C2C drug resistance transporter, Bcr CflA FPL18_RS17495 ENOG4108IG5 Transcriptional regulator FPL18_RS17500 ENOG4105DWU Membrane FPL18_RS17530 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) FPL18_RS17535 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FPL18_RS17550 ENOG4108Z6B deaminase FPL18_RS17570 ENOG4108RTD type II secretion system protein K FPL18_RS17595 ENOG4105F8V Hydrolase, tatD family FPL18_RS17620 ENOG4107QRG dna polymerase iii FPL18_RS17630 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FPL18_RS17635 ENOG4105BZ1 (ABC) transporter FPL18_RS17640 ENOG4105SG9 biopolymer transport protein, ExbD FPL18_RS17650 ENOG4105FA0 parb-like partition protein FPL18_RS17655 ENOG4107QJE Chromosome Partitioning Protein FPL18_RS17665 ENOG4108S0S Nucleotidyl transferase FPL18_RS17670 ENOG4105EHM Aminoglycoside phosphotransferase FPL18_RS17675 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FPL18_RS17680 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FPL18_RS17685 ENOG4105D2N Aldolase FPL18_RS17690 ENOG4105C1J atp-dependent rna helicase FPL18_RS17695 ENOG4105VEQ Cold shock protein FPL18_RS17705 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL18_RS17710 ENOG4105M08 Membrane FPL18_RS17755 ENOG4105CYB regulatoR FPL18_RS17760 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FPL18_RS17765 ENOG4105E0Y RtcB Protein FPL18_RS17780 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP FPL18_RS17785 ENOG4105CIN aminoacyl-histidine dipeptidase FPL18_RS17795 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FPL18_RS17800 ENOG4105CQC Prephenate dehydratase FPL18_RS17815 ENOG4105C1G acyl-Coa dehydrogenase FPL18_RS17840 ENOG4105VUT cytoplasmic protein FPL18_RS17845 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FPL18_RS17850 ENOG4105BZ4 penicillin-binding protein FPL18_RS17860 ENOG4105M6F mutator MutT protein FPL18_RS17870 ENOG4105DHQ Histidine kinase FPL18_RS17875 ENOG4105XJC Two component transcriptional regulator (Winged helix family FPL18_RS17885 ENOG4107QHF type ii secretion system protein e FPL18_RS17890 ENOG4108R96 Methyltransferase, YaeB family FPL18_RS17895 ENOG4105DP0 ferredoxin-NADP reductase FPL18_RS17915 ENOG4105DZ2 Transcriptional regulator FPL18_RS17920 ENOG4105WPN DNA integration recombination invertion protein FPL18_RS17930 ENOG4105F27 Major Facilitator FPL18_RS17935 ENOG4108R5S membrane FPL18_RS17945 ENOG4108IPW abc transporter atp-binding protein FPL18_RS17950 ENOG4105CM4 permease protein FPL18_RS17955 ENOG4105DHS permease protein FPL18_RS17960 ENOG4105EYW Ion transport protein FPL18_RS17965 ENOG4107QPK )-transporter FPL18_RS17980 ENOG4105E6M Sulphatase-modifying factor protein FPL18_RS17985 ENOG4107QIJ Aconitate hydratase 2 FPL18_RS18010 ENOG4105CFU surface antigen FPL18_RS18015 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) FPL18_RS18040 ENOG4105KRF dihydroneopterin aldolase FPL18_RS18050 ENOG4105D06 uba thif-type nad fad binding protein FPL18_RS18065 ENOG4107IFA Lipase (EC 3.1.1.3) FPL18_RS18075 ENOG4108MEJ flavin reductase domain protein FPL18_RS18105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL18_RS18110 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FPL18_RS18120 ENOG4108Z12 YiaAB two helix domain-containing protein FPL18_RS18130 ENOG4105CFP Peptidase U32 FPL18_RS18135 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FPL18_RS18175 ENOG4108HW3 (ABC) transporter FPL18_RS18180 ENOG4105MRR Transcriptional regulator (By similarity) FPL18_RS18185 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL18_RS18230 ENOG4105DA5 (ABC) transporter FPL18_RS18235 ENOG4105E3A (ABC) transporter FPL18_RS18250 ENOG4105CNI cell division protein FtsW FPL18_RS18255 ENOG4105CVE Lytic murein transglycosylase FPL18_RS18280 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) FPL18_RS18285 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FPL18_RS18300 ENOG4105CQ7 ATP-dependent helicase FPL18_RS18305 ENOG4105D3R alkyl hydroperoxide reductase FPL18_RS18315 ENOG4105EEF Alkane 1-monooxygenase FPL18_RS18335 ENOG4108JU3 Alkyl hydroperoxide reductase FPL18_RS18345 ENOG4108K3A Glutathione S-transferase FPL18_RS18355 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FPL18_RS18395 ENOG4105CS6 Rhs element vgr protein FPL18_RS18410 ENOG4105UYK outer membrane protein a FPL18_RS18420 ENOG4105CD3 dihydroorotase FPL18_RS18445 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL18_RS18455 ENOG4108UKZ OsmC family FPL18_RS18460 ENOG4107RYR Transcriptional regulator, Crp Fnr family FPL18_RS18465 ENOG4108K0D peptidase, M48 FPL18_RS18470 ENOG4105JQZ Methyltransferase FPL18_RS18475 ENOG4105F95 Monooxygenase FPL18_RS18510 ENOG4105X1Q TOBE domain protein FPL18_RS18515 ENOG4107SM7 Transcriptional regulator FPL18_RS18525 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL18_RS18540 ENOG4105DG7 nitrate ABC transporter FPL18_RS18545 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL18_RS18565 ENOG4105CPC Aldo Keto reductase FPL18_RS18570 ENOG4105CPU Monooxygenase FPL18_RS18575 ENOG4105GR3 Histidine kinase FPL18_RS18585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL18_RS18590 ENOG4105C1P efflux transporter, rnd family, mfp subunit FPL18_RS18595 ENOG4105BZS acriflavin resistance protein FPL18_RS18600 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FPL18_RS18625 ENOG4107RN6 Monooxygenase FPL18_RS18635 ENOG4105EZR dyp-type peroxidase family protein FPL18_RS18640 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL18_RS18645 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FPL18_RS18665 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL18_RS18670 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL18_RS18675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL18_RS18680 ENOG4108ZX5 transcriptional regulator FPL18_RS18690 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FPL18_RS18720 ENOG4105D82 Glutamate dehydrogenase FPL18_RS18725 ENOG41088SP formiminoglutamate hydrolase FPL18_RS18735 ENOG4105C85 amino acid FPL18_RS18750 ENOG41090B9 response to stress FPL18_RS18755 ENOG4105CZE histidine utilization repressor FPL18_RS18765 ENOG4105SKE transcriptional Regulator LysR family FPL18_RS18775 ENOG4105NAE bifunctional deaminase-reductase domain protein FPL18_RS18785 ENOG4105F37 PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 FPL18_RS18795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL18_RS18800 ENOG4105D7T ABC transporter FPL18_RS18805 ENOG4107XKF NMT1 THI5 Like Domain Protein FPL18_RS18825 ENOG4108Z2U ureidoglycolate hydrolase FPL18_RS18830 ENOG4105DHG Allantoate amidinohydrolase FPL18_RS18835 ENOG41073TP transcriptional regulator FPL18_RS18840 ENOG41061H0 Monooxygenase FPL18_RS18845 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FPL18_RS18855 ENOG4105C2W permease FPL18_RS18860 ENOG4105VT2 5-hydroxyisourate hydrolase FPL18_RS18870 ENOG4105DZG Dehydrogenase FPL18_RS18875 ENOG4105TW1 Carbohydrate-selective porin OprB FPL18_RS18880 ENOG4106JPM 3-dehydroshikimate dehydratase FPL18_RS18885 ENOG4105FF2 Type I DHQase FPL18_RS18890 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha FPL18_RS18895 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta FPL18_RS18900 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FPL18_RS18905 ENOG4105D2S major facilitator superfamily FPL18_RS18910 ENOG4105F2Z 3-oxoadipate enol-lactonase FPL18_RS18915 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase FPL18_RS18920 ENOG4105CHU acetyl-coa acetyltransferase FPL18_RS18925 ENOG4107QNJ CoA-transferase subunit B FPL18_RS18930 ENOG4107QP7 CoA-transferase subunit A FPL18_RS18935 ENOG4107HP6 Transcriptional regulator FPL18_RS18945 ENOG4105CEB Aspartate aminotransferase FPL18_RS18950 ENOG4105E3J oxidoreductase FPL18_RS18955 ENOG4105C26 Dehydrogenase FPL18_RS18960 ENOG4105DVW rieske (2Fe-2S) FPL18_RS18970 ENOG4105C94 Transporter FPL18_RS18975 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FPL18_RS18980 ENOG4105EJC lysr family transcriptional regulator